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Anne-Valerie Gendrel obtained her PhD degree from University Paris Sud (Paris, France) in 2005, under the supervision of Dr. Vincent Colot, working on the epigenetic control of transposons in the model plant Arabidopsis thaliana. She then joined the group of Prof. Neil Brockdorff at the MRC-Clinical Sciences Centre in London (UK) for a first postdoc (2005-2009), with an EMBO and then a HFSP postdoctoral fellowship, to investigate the role of DNA methylation in X-chromosome inactivation and monoallelic expression of autosomal genes in the mouse genome. She then moved back to France joining the group of Prof. Edith Heard in the Institut Curie in Paris (France), to develop and supervise a novel project aimed at identifying new genes expressed in random monoallelic fashion on autosomes in the mouse genome and their role in development and disease. In October 2014, she obtained a competitive research position (chargé de recherche) with Inserm in the group of Prof Edith Heard, where she started developing functional approaches to unravel the role of transposable elements in genome regulation during development and in disease contexts. In 2019, she under-took a one-year sabbatical in Instituto de Medicina Molecular (iMM, Lisbon, Portugal) and she was recently awarded with an FCT investigator position to carry on her research projects in iMM (2021-2026). She has so far published 22 articles in international peer review journals with an accumulated impact factor of 362, with over 2700 citations and a h-index of 17 (source Scopus) and 1 article deposited on the bioRxiv preprint server. This includes 5 first author research articles in Nature (Impact Factor - IF: 41.577), Science (IF: 41.058), Developmental cell (IF: 9.616) and Molecular & cellular biology (IF: 3.813), 4 first author review articles, including one in Annual Reviews in Developmental Biology (IF: 9.032), one first author method article in Nature methods (IF: 26.919) and 6 articles as corresponding author. She supervised over 10 students and research technicians since 2014. She has been involved in teaching and was an examiner in various evaluation committees, including PhD defenses. Finally, she has been acting as a ad hoc scientific peer reviewer for various journals and a consultant for projects submitted to the European Commission.
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Identification

Personal identification

Full name
Anne-Valerie GENDREL

Citation names

  • Gendrel, Anne-Valerie

Author identifiers

Ciência ID
1917-59ED-F318

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Intermediate (B1) Elementary (A2) Beginner (A1) Upper intermediate (B2) Elementary (A2)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2001/10/01 - 2005/02/18
Concluded
 Thèse de doctorat en sciences biologiques, génétique (Doctorat)
Major in Molecular Biology
Université Paris-Sud Faculté des Sciences d'Orsay, France
"Epigenetic control of transposable elements in the model plant system Arabidopsis thaliana, and its impact on gene expression" (THESIS/DISSERTATION)
 Mention Tres Honorable
2000/10/01 - 2001/09/05
Concluded
 DEA de Génétique (DEA)
Université Paris VII Denis Diderot UFR Sciences du Vivant, France
"Experimental validation of the use of chromosomal microarrays in the model plant Arabidopsis thaliana" (THESIS/DISSERTATION)
1998/10/01 - 2001/09/05
Concluded
 Magistère de Génétique (Magister (2nd cycle))
Université Paris VII Denis Diderot UFR Sciences du Vivant, France
 Mention très bien
Affiliation

Science

Category
Host institution 		Employer
2020/12/15 - Current Auxiliary Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/11/01 - 2020/12/15 Visiting Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/10/01 - 2019/11/01 Researcher (Research) INSERM Délégation régionale Paris 6, France
Institut Curie Centre de Recherche, France
2009/10/01 - 2014/09/30 Postdoc (Research) Institut Curie, France
Institut Curie Centre de Recherche, France
2005/05/01 - 2009/04/01 Postdoc (Research) Medical Research Council, United Kingdom
Projects

Grant

Designation Funders
2023/03/01 - Current New horizons for Rett syndrome: exploring the role of transposable elements using genetically engineered human stem cell models
2022.02195.PTDC
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/15 - Current Dissecting the molecular mechanisms of X-chromosome inactivation using embryonic stem cells
2022.01532.PTDC
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/12/01 - Current Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome
3909
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Rettsyndrome.org
Ongoing
2021/01/01 - Current Decoding the Role of DNA Break-Induced Transcription in Ageing
PTDC/MED-OUT/4301/2020
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 X-chromosome Inactivation in Systemic Lupus Erythematosus
EXPL/MED-OUT/1517/2021
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2014/03/01 Epigenetic regulation of random monoallelic gene expression during development and in disease
250367
Post-doc Fellow
Institut Curie, France
 European Research Council
Concluded
2006/05/01 - 2010/09/01 Role of the SmcHD1 protein on X chromosome inactivation and transposable element silencing
HFSP LT00553/2006-L
Post-doc Fellow
Medical Research Council - Clinical Sciences Centre, United Kingdom

Institut Curie Centre de Recherche, France
Human Frontier Science Program
Concluded
2005/07/01 - 2006/05/01 The role of LINE transposable elements on X-chromosome inactivation
EMBO ALTF 176-2005
Post-doc Fellow
Medical Research Council - Clinical Sciences Centre, United Kingdom
 European Molecular Biology Organisation
Concluded

Contract

Designation Funders
2020/10 - Current Unravelling the extent and the mechanisms by which L1 retrotransposons can influence genome function and stability
CEECIND/02085/2018
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2019/09/30 Functional analysis of the role of LINE-1 retrotransposons in X-chromosome inactivation
671027
Researcher
Institut Curie, France

INSERM Délégation régionale Paris 6, France
European Research Council

INSERM
Concluded
2008/04/01 - 2009/04/17 Function of structural-maintenance-of chromosome hinge domain containing protein 1 (Smchd1) in X-chromosome inactivation and autosomal gene regulation.
081385
Post-doc Fellow
Medical Research Council - Clinical Sciences Centre, United Kingdom

University of Oxford Department of Biochemistry, United Kingdom
Wellcome Trust
Concluded
Outputs

Publications

Book chapter
  1. GENDREL, ANNE-VALERIE. "Transposable elements, RNA interference, and the origin of heterochromatin". In RNAi: A Guide to Gene Silencing, edited by Gregory J. Hannon, 129-148. Cold Spring Harbor, United States: CSHL press, 2003.
    Published
Journal article
  1. Le Breton, Anna; Bettencourt, Margarida P.; Gendrel, Anne-Valerie. "Navigating the brain and aging: exploring the impact of transposable elements from health to disease". Frontiers in Cell and Developmental Biology 12 (2024): http://dx.doi.org/10.3389/fcell.2024.1357576.
    Published • 10.3389/fcell.2024.1357576
  2. Maria Arez; Melanie Eckersley-Maslin; Tajda Klobucar; João von Gilsa Lopes; Felix Krueger; Annalisa Mupo; Ana Cláudia Raposo; et al. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation". Nature Communications (2022): https://doi.org/10.1038/s41467-022-33013-5.
    10.1038/s41467-022-33013-5
  3. Ana Cláudia Raposo; Miguel Casanova; Anne-Valerie Gendrel; Simão Teixeira da Rocha. "The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation". Biochemical Society Transactions (2021): https://doi.org/10.1042/BST20210253.
    10.1042/BST20210253
  4. Vasco M Barreto; Kubasova, Nadiya; Clara F Alves-Pereira; GENDREL, ANNE-VALERIE. Corresponding author: GENDREL, ANNE-VALERIE. "X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as 'Faux Amis'". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.740937.
    Open access • Published • 10.3389/fcell.2021.740937
  5. Marion-Poll, Lucile; Forêt, Benjamin; Zielinski, Dina; Massip, Florian; Attia, Mikael; Carter, Ava C.; Syx, Laurène; et al. Corresponding author: Gendrel, Anne-Valerie. "Locus specific epigenetic modalities of random allelic expression imbalance". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-25630-3.
    Published • 10.1038/s41467-021-25630-3
  6. da Rocha, Simão Teixeira; Gendrel, Anne-Valerie. "The influence of DNA methylation on monoallelic expression". Essays in Biochemistry 63 6 (2019): 663-676. http://dx.doi.org/10.1042/ebc20190034.
    10.1042/ebc20190034
  7. Xu J; Carter AC; Gendrel AV; Attia M; Loftus J; Greenleaf WJ; Tibshirani R; Heard E; Chang HY. "Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.". (2017): http://europepmc.org/abstract/med/28112738.
    10.1038/ng.3769
  8. Gendrel AV; Marion-Poll L; Katoh K; Heard E. "Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.". (2016): http://europepmc.org/abstract/med/27101886.
    10.1016/j.semcdb.2016.04.007
  9. Brideau NJ; Coker H; Gendrel AV; Siebert CA; Bezstarosti K; Demmers J; Poot RA; Nesterova TB; Brockdorff N. "Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.". (2015): http://europepmc.org/abstract/med/26391951.
    10.1128/mcb.00432-15
  10. Gendrel AV; Attia M; Chen CJ; Diabangouaya P; Servant N; Barillot E; Heard E. "Developmental dynamics and disease potential of random monoallelic gene expression.". (2014): http://europepmc.org/abstract/med/24576422.
    10.1016/j.devcel.2014.01.016
  11. Gendrel AV; Heard E. "Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.". (2014): http://europepmc.org/abstract/med/25000994.
    10.1146/annurev-cellbio-101512-122415
  12. Chelmicki T; Dündar F; Turley MJ; Khanam T; Aktas T; Ramírez F; Gendrel AV; et al. "MOF-associated complexes ensure stem cell identity and Xist repression.". (2014): http://europepmc.org/abstract/med/24842875.
    10.7554/elife.02024
  13. Gendrel AV; Tang YA; Suzuki M; Godwin J; Nesterova TB; Greally JM; Heard E; Brockdorff N. "Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.". (2013): http://europepmc.org/abstract/med/23754746.
    10.1128/mcb.00145-13
  14. Corbel C; Diabangouaya P; Gendrel AV; Chow JC; Heard E. "Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.". (2013): http://europepmc.org/abstract/med/23362347.
    10.1242/dev.087429
  15. Gendrel AV; Apedaile A; Coker H; Termanis A; Zvetkova I; Godwin J; Tang YA; et al. "Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.". (2012): http://europepmc.org/abstract/med/22841499.
    10.1016/j.devcel.2012.06.011
  16. Gendrel AV; Heard E. "Fifty years of X-inactivation research.". (2011): http://europepmc.org/abstract/med/22069183.
    10.1242/dev.068320
  17. Blewitt ME; Gendrel AV; Pang Z; Sparrow DB; Whitelaw N; Craig JM; Apedaile A; et al. "SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.". (2008): http://europepmc.org/abstract/med/18425126.
    10.1038/ng.142
  18. Gendrel AV; Colot V. "Arabidopsis epigenetics: when RNA meets chromatin.". (2005): http://europepmc.org/abstract/med/15752993.
    10.1016/j.pbi.2005.01.007
  19. Gendrel AV; Lippman Z; Martienssen R; Colot V. "Profiling histone modification patterns in plants using genomic tiling microarrays.". (2005): http://europepmc.org/abstract/med/16163802.
    10.1038/nmeth0305-213
  20. Lippman Z; Gendrel AV; Colot V; Martienssen R. "Profiling DNA methylation patterns using genomic tiling microarrays.". (2005): http://europepmc.org/abstract/med/16163803.
    10.1038/nmeth0305-219
  21. Lippman Z; Gendrel AV; Black M; Vaughn MW; Dedhia N; McCombie WR; Lavine K; et al. "Role of transposable elements in heterochromatin and epigenetic control.". (2004): http://europepmc.org/abstract/med/15269773.
    10.1038/nature02651
  22. Mathieu O; Jasencakova Z; Vaillant I; Gendrel AV; Colot V; Schubert I; Tourmente S. "Changes in 5S rDNA chromatin organization and transcription during heterochromatin establishment in Arabidopsis.". (2003): http://europepmc.org/abstract/med/14630972.
    10.1105/tpc.017467
  23. Gendrel AV; Lippman Z; Yordan C; Colot V; Martienssen RA. "Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1.". (2002): http://europepmc.org/abstract/med/12077425.
    10.1126/science.1074950
Newspaper article
  1. Yves Deveaux; GENDREL, ANNE-VALERIE; Vincent Colot. "Interférence ARN et contrôle chromatinien de l'activité du génome", BioFutur, 2004
Preprint
  1. Pérez-Rico, Yuvia A; Bousard, Aurélie; Misikova, Lenka Henao; Mulugeta, Eskeatnaf; de Almeida, Sérgio F; Muotri, Alysson R; Heard, Edith; Gendrel, Anne-Valerie. "Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential". 2024. http://dx.doi.org/10.1101/2024.02.20.581275.
    10.1101/2024.02.20.581275
  2. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Raposo, Ana Cláudia; Gendrel, Anne-Valerie; de Jesus, Bruno Bernardes; da Rocha, Simão Teixeira. "Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs". 2020. http://dx.doi.org/10.1101/2020.11.20.370973.
    10.1101/2020.11.20.370973
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05/23 Evaluating the cis-regulatory potential of full-length LINE-1 elements. Seminar invitation from Dr. Philippe Arnaud.
Institute of Genetics, Reproduction and Development (iGReD) ( Clermont-Ferrand, France)
2022/10/19 Evaluating the cis-regulatory potential of full-length LINE-1 elements EpIC conference - EpiGene3Sys meets INC-Spain to ChromDesign the Genome
Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica (GENYO) (Granada, Spain)
2021/05/31 Regulation of monoallelic expression: beyond X-chromosome inactivation Invited lecture for Institute of Genetics and Biophysics
Institute of Genetics and Biophysics (Naples, Italy)
2017/09/19 Regulation of monoallelic gene expression: X-chromosome inactivation and beyond CBI call for recruitment of group leaders
Centre de Biologie Integrative (Toulouse, France)
2016/10/11 Exploring the regulation of LINE-1 elements and their role in X inactivation and gene expression in the mouse IGFL call for group leaders
Institut de Génomique Fonctionnelle de Lyon, France (Lyon, France)
2015/11/15 Autosomal Random Monoallelic Gene Expression in Development and Disease SyBoSS (Systems Biology of Stem Cells and Reprogramming) consortium final meeting
(PARIS, France)
2015/06/01 The developmental dynamics and disease potential of random monoallelic expression Invitation from Dr. Eric Gilson
Institute of Research cancer and aging in Nice (IRCAN) (Nice, France)
2015/05/27 Investigating the dynamics and mechanisms underlying random monoallelic expression during development Invitation from Dr. Pierre-Olivier Couraud
Institut Cochin (Paris, France)
2014/05/13 The developmental dynamics and disease potential of random monoallelic expression Invitation from Dr. Robert Feil
Institut de Génétique Moléculaire de Montpellier (IGMM) (Montpellier, France)
2013/05 Random monoallelic expression in development and disease Colloque “Epigenetic Mechanisms and Genetic Disease”
Collège de France (Paris, France)
2011/09 Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome ICC meeting on Imprinting and beyond: monoallelic regulation in health and disease
(Barcelona, Spain)
2011/07 Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome 50 Years of X-inactivation Research
EMBO Workshop (Oxford, United Kingdom)
2010/01/29 Investigating the function of the Smchd1 protein, a new regulator of epigenetic gene silencing Epigenome NoE Workshop, X inactivation and imprinting
(Emmetten, Switzerland)
2005/04/27 Transposable elements, heterochromatin and epigenetic control in Arabidopsis Invitation from Dr. Anton Wutz (EMBO interview)
Research Institute of Molecular Pathology (IMP) (Vienna, Austria)
2005/03/16 Epigenetic regulation of transposable elements and genome expression in Arabidopsis Invited seminar by Dr. Philippe Arnaud
Institut de Génétique Moléculaire de Montpellier (IGMM) (Montpellier, France)
2004/11/18 Role of transposable elements in heterochromatin and epigenetic control in Arabidopsis Invited seminar by Prof. Ueli Grossniklaus
Institute of Plant Biology, University of Zürich (Zurich, Switzerland)
2004/09/10 Transposable elements, heterochromatin and epigenetic control in Arabidopsis Invited seminar by Prof. Neil Brockdorff
MRC - Clinical Sciences Centre (London, United Kingdom)
2004/07 Chromosome wide analysis of transposon-mediated gene regulation in Arabidopsis XIIème colloque Eléments transposables
(Tours, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/01/10 - Current Functional approaches to investigate the role of LINE-1 elements in the maintenance of X-chromosome inactivation
Supervisor of Anna Le Breton
 Research technician (Other)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/02/09 - 2023/11/28 Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome
Supervisor of Margarida Bettencourt
 Mestrado em Engenharia Biomédica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/11/01 - 2022/10/31 Uncovering the role of retrotransposons in the cellular aging process, using a Progeria cell model
Supervisor of Pedro Miguel Cordeiro Sousa
 25.º PROGRAMA - EDUCAÇÃO PELA CIÊNCIA (2021/2022) (Master)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2022/03/28 - 2022/08/26 Investigating the role of line-1 elements on gene expression and X-chromosome inactivation
Supervisor of Romane Gulh
 Master 1 in Genetics - Magistere Europeen de Genetique (Master)
Université Paris VII Denis Diderot UFR Sciences du Vivant, France

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/02/15 - 2021/11/30 Investigating the role of LINE-1 elements in gene expression and genome stability through functional approaches
Supervisor of Inês Cardial Mendes Dias
 Mestrado Integrado em Engenharia Biológica (MIEB) - Tecnico Lisboa (Master)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/03 - 2020/11/30 Exploring the impact of LINE-1 retrotransposons activation or repression on gene expression in mouse ES cells
Supervisor of Lenka Henao Misiková
 Erasmus MSc student (Master)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/10/01 - 2019/04/01 Exploring the mechanims underlying random monoallelic expression during differentiation of mouse ES cells into neural progenitor cells
Co-supervisor of Benjamin Forêt
 Research technician (Other)
Institut Curie, France
2017/01/01 - 2017/06/20 Assessing the role of active LINE-1 transcription on X-chromosome inactivation
Supervisor of Yann Meheust
 Master 2 student, Ecole Normale Superieure de Lyon (Lyon, France) (Master)
Institut Curie, France
2016/02/15 - 2016/12/31 Developing functional approaches to investigate the role of LINE-1 transposable elements in X-chromosome inactivation in mouse ES cells
Supervisor of Valentina Carlini
 Master 2. Erasmus + project Unipharma-Graduates (Italy) (Master)
Institut Curie, France
2015/09/01 - 2016/02/15 Development of functional approaches to explore random monoallelic expression and X-chromosome inactivation during mouse ES cell differentiation
Supervisor of Kalliopi Chatzovoulou
 Bachelor student, Erasmus plus placement programme, University of Thessaly (Volos, Greece) (Degree)
Institut Curie, France
2013/04/01 - 2013/06/01 Exploring the random monoallelic expression of Eya genes genes after differentiation of mouse ES cells into neural progenitor cells
Supervisor of Jacques Serizay
 Bachelor, Ecole Normale Superieure de Cachan, Cachan, France (Degree)
Institut Curie, France
2006/05/01 - 2006/08/01 Smchd1 as a Potential Modulator of Gene Silencing
Supervisor of Thomas Spruce
 MRes Biomedical Sciences Degree, MRC, UK (Master)
Medical Research Council - Clinical Sciences Centre, United Kingdom
2005/10/01 - 2005/12/31 Investigating the correlation between L1 density and CpG methylation in X chromosome inactivation
Supervisor of Emily Brookes
 MRes Biomedical Sciences Degree, MRC, UK (Master)
Medical Research Council - Clinical Sciences Centre, United Kingdom
2003/02/01 - 2003/05/30 Characterization of the reactivation of genes located on the heterochromatic knob on Arabidospsis thaliana chromosome 4
Supervisor of Nathanaël Lemonnier
 Master of Science - Université Denis Diderot (Paris VII) (Master)
Plant Genomics Research Unit - Unité de recherche en Génomique Végétale, France

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/19 - 2023/06/22 Poster presentation: Evaluating the cis-regulatory potential of full-length LINE-1 elements: implications for X-chromosome inactivation.
Conference
 EMBO workshop: X-chromosome inactivation: New insights on its 60th anniversary, Berlin, Germany.
European Molecular Biology Organisation, Germany
2023/06/05 - 2023/06/07 Poster presentation: Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome.
Meeting
 2023 IRSF Rett Syndrome Scientific Meeting
Rettsyndrome.org, United States
2019/06/07 - 2019/06/07 Oral presentation for the general public - festival 'Nuit Sciences et Lettres'. Au-delà du déterminisme génétique: variabilité du vivant et diversité permis par l’épigénétique.
Festival
 Nuit Sciences et Lettres
École Normale Supérieure, France
2014/08/30 - 2014/09/04 Poster presentation: Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression.
Conference
 EMBO-FEBS anniversary conference, Paris, France
European Molecular Biology Organisation, Germany

Federation of European Biochemical Societies, United Kingdom
2011/09/21 - 2011/09/23 Poster presentation: Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
Conference
 ICC on Genomic Imprinting and Beyond
Institut d'Investigació Biomèdica de Bellvitge, Spain
2008/07/06 - 2008/07/09 Poster presentation: The SmcHD1 protein, a new regulator of epigenetic gene silencing in X-chromosome inactivation
Meeting
 Eight HFSP awardees annual meeting, Berlin, Germany
Human Frontier Science Program, France
2004/05/28 - 2004/06/02 Poster presentation: Chromosome-wide analysis of epigenetic variation in Arabidopsis.
Symposium
 Cold Spring Harbor Symposium on Epigenetics, NY, USA.
Cold Spring Harbor Laboratory, United States
2003/06/19 - 2003/06/22 Poster presentation: Global profiling of transcription and epigenetic marks across a heterochromatic region in Arabidopsis.
Conference
 First Alan Wolffe EMBO Workshop on Chromatin and Epigenetics, Heidelberg, Germany.
European Molecular Biology Organisation, Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/28 Developing human stem cell models to explore the contribution of transposable elements for the pathophysiology of Rett syndrome.
Supervisor
 Margarida Pinho Gonçalves Bento de Bettencourt (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/23 Exploring the role of the ESCRT-III proteins in response to telomeric replication stress in ALT cancer cells
(Thesis) Main arguer
 Inês Vaz Fernandes Teixeira Justo (Master)
Universidade Nova de Lisboa, Portugal
2021/12/03 PhD thesis - X chromosome transcriptional activity in humans, from early embryonic stages to adult somatic cells
(Thesis) Arguer
 Louis Chauviere (PhD)
Université de Paris, France
2021/11/30 Establishing cellular models to investigate the role of LINE-1 elements in X-chromosome inactivation and genome stability
Supervisor
 Inês Cardial Mendes Dias (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/06/25 Bachelor internship evaluation - TERRA Transcription Upregulation Effects on Telomere Stability and Cell Proliferation
(Thesis) Main arguer
 João Pedro Pina Rebelo (Other)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa, Portugal
2018/09 Master 1 internship evaluation David Benacom (Master)
École Normale Supérieure, France

Université PSL, France
2017/07/06 PhD thesis - The ICF syndrome and emergent players in DNA methylation and development: when studying a rare genetic disease sheds light on an "old" field
(Thesis) Arguer
 Giacomo Grillo (PhD)
Sorbonne Université, France
2006/05 Assessors of MRes rotation report (MRes Biomedical Sciences Degree, MRC, London, UK)
Thesis Member
 Matthew Bishop (Master)
Medical Research Council - Clinical Sciences Centre, United Kingdom

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/05/01 - Current Frontiers in Genetics (1664-8021) Frontiers Media
2022/01 - Current Communications biology (2399-3642) Nature Portfolio
2021/07 - Current G3 Genes, Genomes, Genetics (2160-1836) Genetics Society of America
2020/09 - Current Nature Communications (2041-1723) Nature Portfolio
2020/08 - Current Trends in Genetics (1362-4555) Cell Press
2020/08 - Current FEBS letter (1873-3468) FEBS Press
2018/04 - Current eLife (2050-084X) eLife Sciences Publications Ltd
2017 - Current Philosophical Transactions of the Royal Society B Biological Sciences (1471-2970) The Royal Society
2016 - Current Genes MDPI
2016 - Current Cell Reports (2211-1247) Cell Press
2015 - Current Genome Research (1088-9051) Cold Spring Harbor Laboratory Press
2013 - Current PLoS ONE (1932-6203) Public Library of Science

Consulting

Activity description Institution / Organization
2023/10/05 - 2023/12/08 Expert for HORIZON-MSCA-2023-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Belgium
2022/10/07 - 2022/12/05 Expert for HORIZON-MSCA-2022-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Belgium
2021/11/05 - 2021/12/20 Expert for HORIZON-MSCA-2021-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Belgium
2020/10/01 - 2020/11/10 Expert for H2020-MSCA-IF-2020 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Belgium
2015/02/01 - 2015/05/29 Expert for European Commission FP7 European Commission Seventh Framework Programme for Research and Technological Development, Belgium

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015/11/15 - Current Magistère européen de Génétique Epigenetics (Magister (2nd cycle)) Université Paris VII Denis Diderot UFR Sciences du Vivant, France

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/12/15 - Current Research day - Chair of oral communications' session. 24.º Workshop 'Educação pela Ciência' | Bolsas CHULN/FMUL.
Coordinator
 Universidade de Lisboa Faculdade de Medicina, Portugal
2017/03 - Current Member of the review board of the Institut Curie - IC-3i PhD Program
Evaluator
 Institut Curie, France Institut Curie
2023/05/09 - 2023/05/12 Evaluation of oral presentations. XVI CAML PhD Students Meeting
Evaluator
 Centro Académico de Medicina de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/03 - 2023/03 Evaluation of candidates for the 2023 João Lobo Antunes Merit PhD Thesis Award
Evaluator
 Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/05/04 - 2022/05/06 Evaluation of oral presentations. XV CAML - V NeurUlisboa PhD Students Meeting
Evaluator
 Centro Académico de Medicina de Lisboa, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/10/15 - 2021/11/15 Evaluation of the applications to the Programa 'Educação pela Ciência' | Bolsas CHULN/FMUL 2021-2022
Evaluator
 Universidade de Lisboa Faculdade de Medicina, Portugal
2021/05/05 - 2021/05/07 Evaluation of oral presentations. XIV CAML - IV NeurUlisboa PhD Students Virtual Meeting.
Evaluator
 Universidade de Lisboa Faculdade de Medicina, Portugal

Centro Académico de Medicina de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Distinctions

Other distinction

2020 FCT Stimulus of Scientific Employment, Individual Support - Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal
2014 INSERM researcher position (permanent)
INSERM Délégation régionale Paris 6, France
2007 HFSP post-doctoral fellowship
Human Frontier Science Program, France
2006 EMBO Postdoctoral Fellowship
European Molecular Biology Laboratory, Germany
2004 Fellowship 'fin de thèse' from Fondation Recherche Medicale
Fondation pour la Recherche Médicale, France
2001 PhD fellowship
Gouvernement francais Ministere de l'education nationale, France