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After my graduation in Biochemistry in 2002 by the Faculty of Sciences, University of Lisbon, I performed my PhD at the Center for Neuroscience and Cell Biology, University of Coimbra, and in other internationally recognized centres (Department of Pharmacology of the University of Cambridge; Department of Physiology of the University College of London, Univ. Complutense Madrid; and Instituto Ramon y Cajal, Madrid, Spain) dedicated to the physio-pathological role of synaptic purinergic receptors, either directly or through the interaction with other receptor signalling systems. In 2007, I moved to Prof. Juan Lerma’s lab at the Instituto de Neurociencias de Alicante (Spain) for a two-year postdoctoral training, where I could establish a new concept of hybrid ionotropic receptors composed by subunits from different and distant families of receptors, which represents a conceptual breakthrough in receptor signalling systems. In 2009, I was selected as a young investigator in the realm of the Juan de la Cierva programme of the Spanish Government. During this period, I dedicated my work to neuronal and brain development, raising kainate receptors as the key tether linking synaptic contact formation and neuronal maturation. In 2012, I joined CNC to implement a new line of investigation exploring brain disorders: 1) from the perspective of the existence of a reactivation of developmental-related mechanisms in an attempt to recover from a lesion, but due to the inadequate context become deleterious; or 2)evaluating the long-term impact of defects during brain development in the adulthood.
Identification

Personal identification

Full name
Ricardo Jorge Alves Rodrigues
Date of birth
1978/09/07
Gender
Male

Citation names

  • Rodrigues, Ricardo J.

Author identifiers

Ciência ID
1917-1943-C05C
ORCID iD
0000-0002-7631-743X
Scopus Author Id
7103188142

Email addresses

  • ricardojrodrigues@gmail.com (Professional)

Telephones

Mobile phone
  • 968080084 (Personal)
Telephone
  • 239820190 (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular, Faculdade de Medicina, Polo I, 1º piso, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1109&idgrp=1408&IdGrupo=1107&IdSeccao=&hash=39 (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007
Concluded
Biologia (Doutoramento)
Major in Especialidade: Biologia Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Neuromodulatory and Neuroprotective Roles of Synaptic P2 Receptors" (THESIS/DISSERTATION)
Aprovado com distinção e louvor por unanimidade
1996/09/07 - 2002/07/17
Concluded
Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"O ATP como neuromodulador pré-sináptico no hipocampo de rato" (THESIS/DISSERTATION)
17
Affiliation

Science

2012/02/01 - Current Auxiliary Researcher (Research)
CNC.IBILI, Portugal
2009/09/01 - 2012/01/31 Contracted Researcher (Research)
Instituto de Neurociencias, Spain
2007/10/01 - 2009/09/30 Postdoc (Research)
Instituto de Neurociencias, Spain
2003/10/01 - 2007/09/30 Research Trainee (Research)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
2004/09/01 - 2004/12/01 Research Trainee (Research)
University College London Research Department of Neuroscience Physiology and Pharmacology, United Kingdom
2004/07/01 - 2004/08/31 Research Trainee (Research)
Instituto de Neurobiología Ramón y Cajal, Spain
2002/09/01 - 2003/08/31 Research Trainee (Research)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
2002/07/01 - 2002/09/30 Research Trainee (Research)
University of Cambridge Department of Pharmacology, United Kingdom
2001/09/01 - 2002/08/31 Research Trainee (Research)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
2002/03/01 - 2002/04/30 Research Trainee (Research)
Universidad Complutense de Madrid Facultad de Veterinaria, Spain
Projects

Contract

Designation Funders
2018 - 2021/07/05 A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis
PTDC/MED-NEU/28160/2017
Researcher
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2018/06 Hybrid ionotropic receptors: a new concept of receptor
Provided by PTCRIS: 142196
Principal investigator
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2015 - 2017/10 P2Y1R-CRMP2 control synaptic and memory loss in early Alzeheimer's disease
NIRG-15-361884
Principal investigator
Alzheimer Association
2013 - 2016/08 Role of P2Y1R in mossy fiber sprouting - new strategies to arrest epileptogenesis.
M.Curie: Cycle 4-2013-PT-07
European Comission - Erasmus Mundus - ENC-Network
2012 - 2014/08 Physiopathological role of ecto-5`-nucleotidase - a new target for neuroprotection
122005
Provided by PTCRIS: 122005
Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2014/04 Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.
Provided by PTCRIS: 126861
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2009/10 EFFECT OF PURINES IN THE DEVELOPING HIPPOCAMPUS: CONSEQUENCES FOR THE ESTABLISHMENT OF CIRCUITS RELATED TO LEARNING AND MEMORY
Provided by PTCRIS: 74318
74318
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007/12 Modification by chronic caffeine consumption of adenosine neuromodulation in the hippocampus - possible relevance for learning and memory
59601
Provided by PTCRIS: 59601
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007/02 NEUROPROTECTION BY ADENOSINE RECEPTORS: COUPLING ENHANCED ADENOSINE FORMATION WITH A2A RECEPTOR BLOCKADE
59215
Provided by PTCRIS: 59215
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007/02 Characterization of purinergic receptors in hippocampal mossy fibers - role in epilepsy
Provided by PTCRIS: 59135
59135
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2007/02 Control by adenosine of neuro-inflammation
59980
Provided by PTCRIS: 59980
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Outputs

Publications

Journal article
  1. Rodrigues, Ricardo J.. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation.". Cerebral cortex (New York, N.Y. : 1991) (2021): https://doi.org/10.1093/cercor/bhab188.
    10.1093/cercor/bhab188
  2. Joana M. Mateus; Filipa F. Ribeiro; Marta Alonso-Gomes; Rui S. Rodrigues; Joana M. Marques; Ana M. Sebastião; Ricardo J. Rodrigues; Sara Xapelli. "Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders". Journal of Caffeine and Adenosine Research 9 4 (2019): 129-144. https://doi.org/10.1089%2Fcaff.2019.0010.
    10.1089/caff.2019.0010
  3. Rodrigues RJ; Marques JM; Cunha RA. "Purinergic signalling and brain development.". Seminars in cell & developmental biology (2018): http://europepmc.org/abstract/med/30529149.
    10.1016/j.semcdb.2018.12.001
  4. Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death and Disease 9 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS.
    10.1038/s41419-018-0351-1
  5. Comune, M.; Rai, A.; Chereddy, K.K.; Pinto, S.; Aday, S.; Ferreira, A.F.; Zonari, A.; et al. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal of Controlled Release 262 (2017): 58-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025167046&partnerID=MN8TOARS.
    10.1016/j.jconrel.2017.07.007
  6. Ferreira, S.; Marques, J. M.; Alcada-Morais, S.; Leyva-Diaz, E.; Lopez-Bendito, G.; Cunha, R. A.; Rodrigues, R. J.. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Journal of Neurochemistry (2017): https://publons.com/publon/33584030/.
  7. Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin". Brain Research Bulletin 124 (2016): 222-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2016.05.009
  8. Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al. "High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus". Neuroscience 315 (2016): 196-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2015.12.018
  9. Köfalvi, A.; Lemos, C.; Martín-Moreno, A.M.; Pinheiro, B.S.; García-García, L.; Pozo, M.A.; Valério-Fernandes, Â.; et al. "Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease". Neuropharmacology 110 (2016): 519-529. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988025899&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2016.03.015
  10. Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A.. "Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus". Neuropharmacology 105 (2016): 241-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2016.01.022
  11. Ferreira, S.G.; Gonc¸alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS.
    10.1111/bph.12970
  12. Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al. "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience 41 7 (2015): 876-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS.
    10.1111/ejn.12851
  13. Rodrigues, R.J.; Tomé, A.R.; Cunha, R.A.. "ATP as a multi-target danger signal in the brain". Frontiers in Neuroscience 9 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS.
    10.3389/fnins.2015.00148
  14. Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Marques, J.M.; Rodrigues, R.J.; Cunha, R.A.; Rial, D.; Köfalvi, A.. "Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS.
    10.1007/s11302-015-9474-3
  15. Canas, P.M.; Simões, A.P.; Rodrigues, R.J.; Cunha, R.A.. "Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease". Neuropharmacology 76 PART A (2014): 51-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886592954&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2013.08.026
  16. Canas, Paula M.; Rial, Daniel; Simoes, Ana Patricia; Lopes, Joao Pedro; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases". Purinergic Signalling (2014): https://publons.com/publon/8181585/.
  17. Marques, J.M.; Rodrigues, R.J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J.. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation". Journal of Neuroscience 33 46 (2013): 18298-18310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3136-13.2013
  18. Rodrigues, R.J.; Lerma, J.. "Metabotropic signaling by kainate receptors". Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1 4 (2012): 399-410. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877959298&partnerID=MN8TOARS.
    10.1002/wmts.35
  19. Costenla, A.R.; Diógenes, M.J.; Canas, P.M.; Rodrigues, R.J.; Nogueira, C.; Maroco, J.; Agostinho, P.M.; et al. "Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing". European Journal of Neuroscience 34 1 (2011): 12-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955177501&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2011.07719.x
  20. Canas, P.M.; Duarte, J.M.N.; Rodrigues, R.J.; Köfalvi, A.; Cunha, R.A.. "Modification upon aging of the density of presynaptic modulation systems in the hippocampus". Neurobiology of Aging 30 11 (2009): 1877-1884. http://www.scopus.com/inward/record.url?eid=2-s2.0-70049083864&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2008.01.003
  21. Cunha, Rodrigo A.; Almeida, Teresa; Rodrigues, Ricardo J.; Diaz-Hernandez, Miguel; Aleu, Jordi; Franco, Rafael; Solsona, Carles; Miras-Portugal, Maria-Teresa; Ciruela, Francisco. "ATP (P2X1-3) AND alpha 3 beta 2 NICOTINIC ACETYLCHOLINE RECEPTORS INTERACT PHYSICALLY AND FUNCTIONALLY IN HIPPOCAMPAL TERMINALS". Journal of Physiological Sciences (2009): https://publons.com/publon/8181593/.
  22. Rodrigues, R.J.; Canas, P.M.; Lopes, L.V.; Oliveira, C.R.; Cunha, R.A.. "Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats". Neurobiology of Aging 29 10 (2008): 1597-1601. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349116847&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2007.03.025
  23. Donato, R.; Rodrigues, R.J.; Takahashi, M.; Tsai, M.C.; Soto, D.; Miyagi, K.; Villafuertes, R.G.; Cunha, R.A.; Edwards, F.A.. "GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx". Cell Calcium 44 6 (2008): 521-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149111859&partnerID=MN8TOARS.
    10.1016/j.ceca.2008.03.006
  24. Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M.. "Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells". Pancreas 36 3 (2008): 279-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS.
    10.1097/MPA.0b013e31815a8473
  25. Duarte, J.M.N.; Oses, J.P.; Rodrigues, R.J.; Cunha, R.A.. "Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats". Neuroscience 149 2 (2007): 382-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348895686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.08.005
  26. Borycz, J.; Pereira, M.F.; Melani, A.; Rodrigues, R.J.; Köfalvi, A.; Panlilio, L.; Pedata, F.; et al. "Differential glutamate-dependent and glutamate-independent adenosine A 1 receptor-mediated modulation of dopamine release in different striatal compartments". Journal of Neurochemistry 101 2 (2007): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047118657&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04386.x
  27. Köfalvi, A.; Pereira, M.F.; Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A.. "Anandamide and NADA bi-directionally modulate presynaptic Ca 2+ levels and transmitter release in the hippocampus". British Journal of Pharmacology 151 4 (2007): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250159127&partnerID=MN8TOARS.
    10.1038/sj.bjp.0707252
  28. Ciruela, F.; Casadó, V.; Rodrigues, R.J.; Luján, R.; Burgueño, J.; Canals, M.; Borycz, J.; et al. "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers". Journal of Neuroscience 26 7 (2006): 2080-2087. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551294&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3574-05.2006
  29. Rodrigues, R.J.; Almeida, T.; De Mendonça, A.; Cunha, R.A.. "Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus". Journal of Molecular Neuroscience 30 1-2 (2006): 173-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845915664&partnerID=MN8TOARS.
    10.1385/JMN:30:1:173
  30. Degroot, A.; Köfalvi, A.; Wade, M.R.; Davis, R.J.; Rodrigues, R.J.; Rebola, N.; Cunha, R.A.; Nomikos, G.G.. "CB1 receptor antagonism increases hippocampal acetylcholine release: Site and mechanism of action". Molecular Pharmacology 70 4 (2006): 1236-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748938381&partnerID=MN8TOARS.
    10.1124/mol.106.024661
  31. Pereira, D.B.; Rebola, N.; Rodrigues, R.J.; Cunha, R.A.; Carvalho, A.P.; Duarte, C.B.. "TrkB receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus". Journal of Neuroscience Research 83 5 (2006): 832-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645312369&partnerID=MN8TOARS.
    10.1002/jnr.20784
  32. Marques, J.M.; Rodrigues, R.J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T.. "Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin". Journal of Biological Chemistry 281 34 (2006): 24687-24694. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS.
    10.1074/jbc.M603753200
  33. Pinheiro, P.S.; Rodrigues, R.J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O.. "Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses". Neurochemistry International 47 5 (2005): 309-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.05.007
  34. Köfalvi, A.; Rodrigues, R.J.; Ledent, C.; Mackie, K.; Vizi, E.S.; Cunha, R.A.; Sperlágh, B.. "Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: A combined immunochemical and pharmacological analysis". Journal of Neuroscience 25 11 (2005): 2874-2884. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244356828&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4232-04.2005
  35. Rodrigues, R.J.; Almeida, T.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y 1, P2Y2, and/or P2Y4 receptors in the rat hippocampus". Journal of Neuroscience 25 27 (2005): 6286-6295. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844443354&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0628-05.2005
  36. Rebola, N.; Rodrigues, R.J.; Oliveira, C.R.; Cunha, R.A.. "Different roles of adenosine A1, A2A and A 3 receptors in controlling kainate-induced toxicity in cortical cultured neurons". Neurochemistry International 47 5 (2005): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044454590&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.05.009
  37. Rodrigues, R.J.; Alfaro, T.M.; Rebola, N.; Oliveira, C.R.; Cunha, R.A.. "Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum". Journal of Neurochemistry 92 3 (2005): 433-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244264871&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.02887.x
  38. Rebola, N.; Rodrigues, R.J.; Lopes, L.V.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus". Neuroscience 133 1 (2005): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344384157&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2005.01.054
  39. Donato, R; Rodrigues, RJ; Cunha, R; Edwards, FA. "Purinergic control of GABA release". Journal of Neurochemistry (2005): https://publons.com/publon/27547643/.
  40. Rodrigues, R. J.; Oliveira, C. R.; Cunha, R. A.. "Release and neuromodulatory role of ATP in hippocampal synapses". Fundamental & Clinical Pharmacology (2004): https://publons.com/publon/8181529/.
  41. Koefalvi, A.; Rodrigues, R. J.; Cunha, R. A.; Ledent, C.; Vizi, E. S.; Sperlagh, B.. "Comparative immunochemical and pharmacological investigation of the functional CB1 receptors in the Rodent striatum". Fundamental & Clinical Pharmacology (2004): https://publons.com/publon/8181569/.
  42. Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O.. "Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus". Neuroscience Letters 336 2 (2003): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS.
    10.1016/S0304-3940(02)01217-X
  43. Almeida, T.; Rodrigues, R.J.; De Mendonça, A.; Ribeiro, J.A.; Cunha, R.A.. "Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices". Neuroscience 122 1 (2003): 111-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142164967&partnerID=MN8TOARS.
    10.1016/S0306-4522(03)00523-2
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10 Purinergic receptors control neuronal migration during corticogenesis. Sinal 2019 meeting
(Olhão, Portugal)
2019/09/06 Cortical principal neurons migration entails A2AR-driven neuronal polarization and axon formation. 1st European Purines meeting
(Santiago de Compostela, Spain)
2017 Neuronal migration: a critical journey for a healthy brain. XLVI Conferências de Genética Doutor Jacinto Magalhães – Neurogenética Pediátrica
(Porto, Portugal)
2017 Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation. XV meeting SPN 2017
(Portugal)
2016 Adenosine A2A receptors control cortical neurons migration. Brain Without Borders
(Coimbra, Portugal)
2016 P2Y1 receptors control the migration of medial ganglionic eminence-derived interneurons. Brain Without Borders
(Coimbra, Portugal)
2016 Adenosine A2A receptors control axon formation during neuronal development: implications to cortical neuronal migration and epileptogenesis. 7th Special ISN Neurochemistry Conference, 2016
(Coimbra, Portugal)
2016 Role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons. XLV meeting of Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2016 A2A receptors control cortical neurons migration. XLV meeting of Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2014 P2X2/GluN2B: a new hybrid ionotropic receptor complex XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2014 P2Y1R is required for Aß-induced synaptic and memory loss most likely by contributing to the phosphorylation of CRMP2. XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2014 Adenosine A2A receptors influence the establishment of neuronal polarity of rat hippocampal neurons XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2014 The bidirectional modulation of axonal growth of rat hippocampal neurons by P2 receptors should involve a differential regulation of CRMP2 protein. XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2014 The ß-amyloid-induced inhibition of hippocampal long-term potentiation is prevented by a P2Y1 (ATP) receptor antagonist. XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2014 Ontogenic evaluation of purinergic receptors expression in mice brain. XLIV meeting of Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)
2013 P2Y1 receptor is involved in A¿-induced synaptic and memory loss. 27ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Coimbra, Portugal)
2013 CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development. IBMC
(Porto, Portugal)
2013 CRMP2 thethers kainate receptor activity to cytoskeleton dynamics during development. XIII meeting of Portuguese Society for Neuroscience
(Luso, Portugal)
2013 CRMP2 thethers kainate receptor activity to cytoskeleton dynamics during development XLII annual meeting of Portuguese Society of Pharmacology
(Porto, Portugal)
2009 P2X2/NR2B: a new ionotropic receptor complex. 11th Meeting of the Portuguese Society for Neuroscience
(Lisboa, Portugal)
2007 Adenosine A2A receptor blockade prevents memory dysfunction caused by ß-amyloid peptides but not by scopolamine or MK-801. XXXVIII anual meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2007 P2X2/NR2B: a hybrid ionotropic receptor. XII Meeting of Sociedad Española de Neurociencia
(Valencia, Spain)
2007 Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. 21st Biennial Meeting of the International Society for Neurochemistry
(Cancun, Mexico)
2006 Blockade of P2Y1 (ATP) receptors prevents glutamate-induced neurotoxicity in cultured hippocampal neurons. XXXVII Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2006 Anandamide and NADA bi-directionally modulate presynaptic Ca2+- levels and transmitter release via Ca2+ and TASK-3 channel blockade in the hippocampus. XXXVII Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2006 Different transducing systems operated by adenosine A2A receptors transfected in HEK293 cells. XXXVII Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2006 Presynaptic P2 receptors – interaction with other receptors and role in neuroprotection. 8th International Symposium on Adenosine and Adenine Nucleotide
(Ferrara, Italy)
2005 Blockade of P2Y1 receptors prevents Aß1-42-induced apoptosis and neuronal degeneration of rat hippocampal neurons. 19th Meeting of Grupo de Estudos de Envelhecimento Cerebral e Demência
(Tomar, Portugal)
2005 Blockade of P2Y1 receptors prevents Aß1-42-induced apoptosis and neuronal degeneration of rat hippocampal neurons. 9th Meeting of Portuguese Society for Neurosciences
(Luso, Portugal)
2004/03 Presynaptic modulation by P2 receptors in the rat hippocampus. 24th European Winter Conference on Brain Research
(Les Arcs, France)
2004 Presynaptic modulation by P2 receptors in the rat hippocampus. 24th European Winter Conference on Brain Research
(Les Arcs, France)
2003 Presynaptic P2Y1, P2Y2 and/or P2Y4 receptors inhibit the evoked release of glutamate in the rat hippocampus. XXXIV Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2003 Synaptic distribution of kainate receptor subunit in the mouse and rat hippocampus: role in regulating the release of [3H]-glutamate. XXXIV Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2003 Functional interaction between ATP (P2) receptors and nicotinic acetylcholine receptors in the control of noradrenaline release from rat hippocampal nerve terminals. XXXIV Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2003 Adenosine A2A and glutamate mGluR5 receptors facilitate the evoked release of glutamate and are co-located in glutamatergic nerve terminals of the rat striatum. XXXIV Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2003 Presynaptic adenosine A2A receptors facilitate the evoked release of glutamate in the rat striatum. 8th Meeting of Portuguese Society for Neurosciences
(Curia, Portugal)
2002 Subcellular synaptic localization of N- and P/Q type voltage sensitive calcium channels in rat hippocampal synapses. XXXIII Annual Meeting of Portuguese Society of Pharmacology
(Lisboa, Portugal)
2002 Modulation of glutamate evoked release through activation of ATP (P2) receptors in the rat hippocampus. XXXIII Annual Meeting of Portuguese Society of Pharmacology
(Lisboa, Portugal)
2001 Modulation by ATP receptors (P2 receptors) of the evoked release of glutamate in the rat hippocampus. XXXII Annual Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2013/09 - 2020/02/28 The role of purinergic receptors in hippocampal mossy fiber sprouting during epileptogenesis.
Supervisor
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/03 - 2019/01/29 The role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons.
Supervisor of Sofia Alexandra Ramos Ferreira
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/03 - 2018/11/16 The role of adenosine A2A receptor in the migration of cortical principal neurons.
Supervisor of Patrícia Sofia Alçada-Morais
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018/02 - 2018/09 Characterization of the neurocytoskeleton damage in neurodegeneration.
Supervisor of Antonio de Donato
Biologia (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2017/03 - 2018/02 Characterization of Aß-induced P2Y1R-mediated phosphorylation of CRMP2.
Supervisor of Valentina Ruggiero
Scienze e Technologie Genetiche (Master)
Università degli Studi del Sannio, Italy
2013/03 - 2014/03 Purinergic signalling: the role of purinergic receptors in the establishment of synaptic connectivity
Supervisor of Annalisa Manganiello
Biologia (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2012/07 - 2013/07 Role of P2Y receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.
Supervisor of Rui de Oliveira Beleza
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/12/19 - Current Organization of CIBB2019 meeting (2019/12/19 - 2019/12/20)
Meeting (Member of the Organising Committee)
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2019/09/11 Alterations of neuronal K+-Cl- cotransporter KCC2 during status epilepticus: possible impact on GABAergic neurotransmission.
(Thesis) Main arguer
Cinzia Miarelli (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/01/29 The role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons.
Supervisor
Sofia Alexandra Ramos Ferreira (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018/11/16 The role of adenosine A2A receptor in the migration of cortical principal neurons.
Supervisor
Patrícia Sofia Alçada Morais (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018/06/18 Role of Caspr1 and Caspr2 in the regulation of glutamatergic transmission and synaptic plasticity
(Thesis) Arguer
Dominique Moreira Fernandes (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 Adult oligodendrogenesis in a mouse model of multiple sclerosis
(Thesis) Main arguer
Joana Moura Mateus (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/12/20 The role of stargazin in the pathogenesis of psychiatric disorders
(Thesis) Arguer
Gladys Tarcila Lima Caldeira (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/09/14 Behavioral and biochemical characterization of stargazin knock-in mice expressing an intelectual disability-linked mutation
(Thesis) Main arguer
Tiago Batista Abrantes Rondão (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09/08 Pharmacological characterization of an in vitro model of status epilepticus
(Thesis) Main arguer
Bárbara Pinto Correia (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/05/20 Regulation of Local Translation by BDNF: Effects on NMDA Receptor Trafficking
(Thesis) Arguer
Pedro João Madeira Afonso (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/01/21 Purines control Neuron-Glia interaction during neuroinflammation
Thesis Member
Jimmy George (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/09 Ribossomes regulation in axonal development
(Thesis) Main arguer
Helena Sofia Caria Martins (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

Society Organization name Role
2005/06/01 - Current Sociedade Portuguesa de Neurociências membro
2004/01/01 - Current Society for Neuroscience Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10/23 - Current Purinergic signaling and brain development Neurociências (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2013/10/01 - Current Biologia Celular e do Desenvolvimento Humano/ Cytoskeleton and Cell movement Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/04/29 - 2019/05/03 Synapses structure and function Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018/04/09 - 2018/04/20 Synapses, neuronal circuits and behavior Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02/15 - 2017/02/19 Molecular and Cellular Neuroscience Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/04/08 - 2016/04/29 Neuroscience course (Curso de doutoramento (conclusão de unidades curriculares))
2015/04/27 - 2015/04/30 Neurodegenerative disorders Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2015/02/16 - 2015/02/27 Molecular and Cellular Neuroscience Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/03/17 - 2014/03/28 Neuronal migration MIT-Portugal PhD Programme (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/07/01 - 2013/07/05 Integrins, rhoGTPases and cytoskeleton GABBA-PhD programme (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012/10/01 - 2012/10/04 Fundamentals of Neuroscience Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Interview (tv / radio show)

Program Topic
2015/12/08 - Current Bom dia Portugal Projecto financiado pela Alzheimer Association
2015/11/24 - Current Jornal Nacional Grant obtained from Alzheimer Association

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Biotechnology Advances (0734-9750) Elsevier
2016 - Current ACS Chemical Neuroscience (1948-7193) American Chemical Society
2014 - Current Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)

Other jury / evaluation

Activity description Institution / Organization
2019/03/01 - Current Grant reviewer ALS Association ALS Association, United States
2016/01/01 - Current Grant reviewer Alzheimer's Association Alzheimer's Association, United States
Distinctions

Award

2014 "Prémio artigo destaque" award - Best paper in neurosciences in 2014 in Cellular and Molecular Neurobiology
Sociedade Portuguesa de Neurociências, Portugal
2013 Best oral communication in the “Fire Session I- Neurodegeneration and neuroprotection I” of the SPN2013 meeting.
Sociedade Portuguesa de Neurociências, Portugal