???global.info.a_carregar???
Ph.D in Medical Biochemistry and Biophysics Doctoral Program (M2B-PhD) at the University of Lisbon Faculty of Medicine since 2018/03/15. My expertise includes project design and management, data analysis and interpretation, and experimental techniques. My work focuses on developing an anticancer drug based on the advantage of the unique properties of antimicrobial peptides by utilizing those properties for the nano-engineering of AMPs-coated silver nanoparticles.
Identification

Personal identification

Full name
Ítala Cristine Silva

Citation names

  • Silva, I
  • Silva, ÍC

Author identifiers

Ciência ID
181E-1259-41A5
ORCID iD
0000-0002-4589-2757

Email addresses

  • itala.silva@medicina.ulisboa.pt (Professional)

Addresses

  • Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Engineering and Technology - Nano-technology - Nano-materials
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2018/03/15 - 2022/03/15
Ongoing
 Medical Biochemistry and Biophysics Doctoral Programme (M2B-PhD) (Doutoramento)
Major in Medical Biochemistry and Biophysics
Universidade de Lisboa Faculdade de Medicina, Portugal
"Antimicrobial and anticancer activities of peptide-conjugated nanoparticles" (THESIS/DISSERTATION)
2015/02/10 - 2016/12/13
Concluded
 Master in Science (Master)
Major in Basic and applied Immunology
Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto, Brazil
"The role of Interleukin-6 (IL-6) in the neutrophil inflammatory response during infection by Leishmania infantum." (THESIS/DISSERTATION)
2009/02/02 - 2014/02/24
Concluded
 Ciências Biológicas (Bachelor)
Major in Bachelor of Biological Sciences
Universidade Federal de Juiz de Fora, Brazil
"Neutrophils: Classical aspects, Plasticity and new Immunoregulatory functions." (THESIS/DISSERTATION)
Projects

Grant

Designation Funders
2023/09 - Current Nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars
CI23-10134
PhD student
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação 'la Caixa'
Ongoing
2023/03/10 - Current AMP-AgNP conjugates: the mutual reinforcement of antibacterial activity
2022.01991.PTDC
PhD Student Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/03 - Current Antimicrobial and anticancer activities of peptide-conjugated nanoparticles
PD/BD/136880/2018
PhD Student Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2022/01/01 - 2024/12/31 COoperative Mechanical couPling of adherens junctions and focaL adhesIons supporting breast CancEr progression
PTDC/BIA-BFS/0812/2021
10.54499/PTDC/BIA-BFS/0812/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Luizi-Ponzo, A. P; Siviero, T. S; Amorim, E.T; Henriques, D.K; Rocha, L.M; Gomes, H. C. S; Paiva, L.A; et al. "Briófitas do Parque Estadual do Ibitipoca no Herbário Prof. Leopoldo Krieger". In Flora do Parque Estadual do Ibitipoca e seu entorno, 95-122. Juiz de Fora, Brazil: Editora UFJF, 2013.
    Published
Journal article
  1. Patrícia M. Silva; Inês V. da Silva; Maria J. Sarmento; Ítala C. Silva; Filomena A. Carvalho; Graça Soveral; Nuno C. Santos. "Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties". Cells 11 8 (2022): 1308-1308. https://doi.org/10.3390/cells11081308.
    10.3390/cells11081308
  2. Barbosa, Joana C.; Gonçalves, Sónia; Makowski, Marcin; Silva, Ítala C.; Caetano, Tânia; Schneider, Tanja; Mösker, Eva; et al. "Insights into the mode of action of the two-peptide lantibiotic lichenicidin". Colloids and Surfaces B: Biointerfaces 211 (2022): 112308. http://dx.doi.org/10.1016/j.colsurfb.2021.112308.
    10.1016/j.colsurfb.2021.112308
  3. Barbosa, Joana C.; Silva, Ítala C.; Caetano, Tânia; Mösker, Eva; Seidel, Maria; Lourenço, Joana; Süssmuth, Roderich D.; et al. "Assessing the potential of the two-peptide lantibiotic lichenicidin as a new generation antimicrobial". World Journal of Microbiology and Biotechnology 38 1 (2022): http://dx.doi.org/10.1007/s11274-021-03196-y.
    10.1007/s11274-021-03196-y
  4. Marlon H. Cardoso; Lai Y. Chan; Elizabete S. Cândido; Danieli F. Buccini; Samilla B. Rezende; Marcelo D. T. Torres; Karen G. N. Oshiro; et al. "An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold". Chemical Science (2022): https://doi.org/10.1039/D1SC06998E.
    10.1039/D1SC06998E
  5. Marcin Makowski; Silva, I. C.; Constança Pais do Amaral; Sónia Gonçalves; Nuno C. Santos. "Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery". Pharmaceutics (2019): https://www.mdpi.com/1999-4923/11/11/588.
    10.3390/pharmaceutics11110588
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/04 (Oral presentation). Potential anticancer activity of peptide-conjugated silver nanostars. XV CAML·V NeurULisboa PhD Students Meeting
Instituto de Medicina Molecular (Lisbon, Portugal)
2021/09/15 Peptide-conjugated silver nanostars as anticancer agent Young Scientist Program Webinar series-IUPAB-SBBq-SBBf virtual meeting
Pure and Applied Biophysics (IUPAB), Brazilian Society for Biochemistry and Molecular Biology (SBBq) and Brazilian Biophysics Society (SBBf) (virtual format, Brazil)
2016/07/21 Understanding the impact of Interleukin 6 in Neutrophil functions in the control of Leishmania infantum infection. XII Workshop of Immunology
Programa de Pós graduação em Imunologia Básica e Aplicada da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (Ribeirão Preto, Brazil)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/06/03 - 2022/06/03 (Poster presentation). Effect of peptide-coated silver nanostars on breast cancer cells. Ítala C. Silva, Miguel Peixoto de Almeida, Eulália Pereira, Erin M. Tranfeld, Octavio L. Franco, Nuno C. Santos, Sónia Gonçalves.
Meeting
 Biophysics Festival
2021/10/04 - 2021/10/08 (e-poster). Peptide-conjugated silver nanostars as anticancer agent. Ítala C. Silva, Miguel Peixoto de Almeida, Eulália Pereira, Octavio L. Franco, Nuno C. Santo, Sónia Gonçalves.
Congress
 20th IUPAB Congress - 45th Annual Meeting of SBBf - 49th Annual Meeting of SBBq
2021/09/29 - 2021/10/01 (Flash talk pre-recorded). Enhancing anticancer activity of antimicrobial peptide by silver nanostars functionalization. Ítala C. Silva, Miguel Peixoto de Almeida, Eulália Pereira, Erin M. Tranfeld, Octavio L. Franco, Nuno C. Santos, Sónia Gonçalves.
Congress
 2021: Microscopy at the frontiers of science
International Iberian Nanotechnology Laboratory, Portugal
2021/06/14 - 2021/06/16 (Poster Presentation). Improving the anticancer activity of PaMAP1.9-conjugated star-shaped nanoparticles. Ítala C. Silva, Miguel Peixoto de Almeida, Eulália Pereira, Octavio L. Franco, Nuno C. Santo, Sónia Gonçalves.
Congress
 7th International Iberian Biophysics Congress
2021/05/04 - 2021/05/07 (Poster Presentation). Anticancer properties of peptide-conjugated silver nanoparticles. Ítala C. Silva, Miguel Peixoto de Almeida, Eulália Pereira, Octavio L. Franco, Nuno C. Santo, Sónia Gonçalves.
Meeting
 XIV CAML · IV NeurULisboa PhD Students Virtual Meeting
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/07/20 - 2019/07/24 (Poster presentation). Antimicrobial activity of peptide-conjugated silver nanoparticles. Ítala C. Silva, Eulália Pereira, Octavio L. Franco, Nuno C. Santo, Sónia Gonçalves.
Congress
 12th European Biophysics Congress (EBSA), 10th ICBP-IUPAP Biophysics Congress
2019/07/16 - 2019/07/18 (Poster presentation). Peptide-conjugated silver nanoparticles: a promising antimicrobial agent. Ítala C. Silva, Eulália Pereira, Octavio L. Franco, Nuno C. Santo, Sónia Gonçalves.
Meeting
 4th Meeting of the College of Chemistry of ULisboa (4 EQUL)
Universidade de Lisboa, Portugal
2019/05/15 - 2019/05/17 (Poster presentation). Peptide-conjugated silver nanoparticles: a promising antimicrobial agent. Ítala Silva, Eulália Pereira, Octávio L. Franco, Nuno C. Santos, Sónia Gonçalves.
Meeting
 XIII CAML PhD Students' Meeting
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018/07/29 - 2018/07/29 Colégio de Química da Universidade de Lisboa, 2018 Summer School, held at Complexo 3Is of Reitoria da Universidade de Lisboa
Meeting
 Colégio de Química da Universidade de Lisboa, 2018 Summer School
2018/07/27 - 2018/07/28 Colégio de Química da Universidade de Lisboa, Chemistry at ULisboa, held at Reitoria da Universidade de Lisboa
Meeting
 Colégio de Química da Universidade de Lisboa, Chemistry at ULisboa
2018/05/23 - 2018/05/25 XII CAML PhD Students' Meeting, held at Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa.
Meeting
 XII CAML PhD Students' Meeting
Distinctions

Award

2021 SME 2019/2020 Best Poster Award on Life Sciences
International Iberian Nanotechnology Laboratory, Portugal
2020 IUBMB-SBBq Young Scientist Program
International Union of Biochemistry and Molecular Biology, Netherlands
2019 EBSA Bursary for attendance at the 12th EBSA Congress

Other distinction

2012 Sandwich fellowship
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil