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Rui Miguel Borges dos Santos. Concluiu o(a) Doutoramento em Doutoramento em Química, Especialidade em Química-Física em 2000 pelo(a) Universidade de Lisboa Faculdade de Ciências e Licenciatura em Engenharia Química Ramo Biotecnologia em 1992 pelo(a) Universidade de Lisboa Instituto Superior Técnico.
Identification

Personal identification

Full name
Rui Miguel Borges dos Santos

Citation names

  • Borges dos Santos, Rui M.

Author identifiers

Ciência ID
1819-C76F-A567
ORCID iD
0000-0002-4837-244X

Email addresses

  • rmsantos@fc.ul.pt (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2000
Concluded
 Doutoramento em Química, Especialidade em Química-Física (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudos Termoquímicos por Calorimetria Fotoacústica" (THESIS/DISSERTATION)
 Distinção e Louvor
1992
Concluded
 Engenharia Química Ramo Biotecnologia (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2015/09/09 - Current Principal Investigator (Research) Universidade do Algarve - Campus de Gambelas, Portugal
Centro de Ciências do Mar, Portugal
2008/04/01 - 2010/12/31 Principal Investigator (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2011/01/01 - Current Assistant Professor (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2000/08/01 - 2008/03/31 Assistant Professor (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve - Campus de Gambelas, Portugal

Others

Category
Host institution 		Employer
2015/09/09 - Current Collaborator at Centro de Química Estrutural Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
Projects

Contract

Designation Funders
2024/01/01 - Current EUREMAP - European Research Infrastructure for Marine Bioprospecting
HORIZON-INFRA-2023-DEV-01-04-101131663
Researcher
Centro de Ciências do Mar, Portugal
 Horizon Europe
Ongoing
2011/01/01 - 2014/06/30 Termoquímica da Adição de Oxigénio a Radicais de Carbono
PTDC/QUI-QUI/110542/2009
Principal investigator
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 Caracterização Termodinâmica da Activação do Receptor de Pregnanos PXR através da Técnica da Microbalança de Cristal de Quartzo com Calorimetria de Condução de Calor
PTDC/QUI/72631/2006
Principal investigator
Universidade do Algarve, Portugal

Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/04/01 - 2008/06/30 Estudos Teóricos e Experimentais sobre Conformação, Energética e Dinâmica Enzimática do Citocromo CYP3A4
POCI/QUI/63166/2004
Principal investigator
Universidade do Algarve, Portugal

Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Jorge F. Pontes; Hermínio P. Diogo; Eusébio Conceição; Maria P. Almeida; Rui M. Borges dos Santos; Ana Grenha. "Development of a dry powder insufflation device with application in in vitro cell-based assays in the context of respiratory delivery". European Journal of Pharmaceutical Sciences (2024): http://dx.doi.org/10.1016/j.ejps.2024.106775.
    10.1016/j.ejps.2024.106775
  2. Pontes, Jorge F.; Diogo, Hermínio P.; Conceição, Eusebio; Musacchio, Flávia; Borges dos Santos, Rui M.; Grenha, Ana. "Development of a prototype of an aerosolization device for dry powders to improve in vitro cell-based assays in the context of lung delivery". Journal of Aerosol Medicine and Pulmonary Drug Delivery 35 2 (2022): A20-A20. Drug Delivery to the Lungs 2021: https://www.liebertpub.com/doi/abs/10.1089/jamp.2022.ab01.abstracts.
    Published
  3. Almeida, Tânia Santos de; Araújo, Maria Eduarda Machado; Rodríguez, Lucía González; Júlio, Ana; Mendes, Beatriz Garcia; Santos, Rui Miguel Borges dos; Simões, José Artur Martinho. "Influence of preparation procedures on the phenolic content, antioxidant and antidiabetic activities of green and black teas". Brazilian Journal of Pharmaceutical Sciences 55 (2019): http://dx.doi.org/10.1590/s2175-97902019000117695.
    10.1590/s2175-97902019000117695
  4. Gangadhar, K.N.; Pereira, H.; Diogo, H.P.; Borges dos Santos, R.M.; Prabhavathi Devi, B.L.A.; Prasad, R.B.N.; Custódio, L.; et al. "Assessment and comparison of the properties of biodiesel synthesized from three different types of wet microalgal biomass". Journal of Applied Phycology 28 3 (2016): 1571-1578. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939156201&partnerID=MN8TOARS.
    10.1007/s10811-015-0683-5
  5. Agapito, F.; Santos, R.C.; Borges Dos Santos, R.M.; Martinho Simões, J.A.. "The thermochemistry of cubane 50 years after its synthesis: A high-level theoretical study of cubane and its derivatives". Journal of Physical Chemistry A 119 12 (2015): 2998-3007. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925935800&partnerID=MN8TOARS.
    10.1021/jp511756v
  6. Santos, R.C.; Almeida, T.S.; Agapito, F.; Borges dos Santos, R.M.; Martinho Simões, J.A.. "Thermodynamically sick molecules: searching for defective experimental enthalpies of formation values using empirical and quantum chemistry methods". Structural Chemistry (2013): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878648940&partnerID=MN8TOARS.
    10.1007/s11224-013-0294-1
  7. Santos, R.C.; Agapito, F.; Gonçalves, E.M.; Martinho Simões, J.A.; Borges Dos Santos, R.M.. "Energetics of H-atom addition to naphthalene: A thermochemical cycle from tetralin to naphthalene". Journal of Chemical Thermodynamics 61 (2013): 83-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874917254&partnerID=MN8TOARS.
    10.1016/j.jct.2013.01.028
  8. Borges Dos Santos, R.M.; Nunes, P.M.; Martinho Simões, J.A.. "The a-C-H BDE in tetralin: A time-resolved photoacoustic calorimetry study". Journal of Thermal Analysis and Calorimetry 100 2 (2010): 381-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951257130&partnerID=MN8TOARS.
    10.1007/s10973-009-0632-0
  9. Nunes, P.M.; Estació, S.G.; Lopes, G.T.; Agapito, F.; Santos, R.C.; Costa Cabral, B.J.; Dos Santos, R.M.B.; Martinho Simões, J.A.. "Energetics of terf-butoxyl addition reaction to norbornadiene: A method for estimating the p-bond strength of a carbon-carbon double bond". Journal of Physical Chemistry A 113 23 (2009): 6524-6530. http://www.scopus.com/inward/record.url?eid=2-s2.0-66649100489&partnerID=MN8TOARS.
    10.1021/jp900089t
  10. Agapito, F.; Nunes, P.M.; Costa Cabral, B.J.; Borges Dos Santos, R.M.; Martinho Simões, J.A.. "Energetic differences between the five- and six-membered ring hydrocarbons: Strain energies in the parent and radical molecules". Journal of Organic Chemistry 73 16 (2008): 6213-6223. http://www.scopus.com/inward/record.url?eid=2-s2.0-50149089387&partnerID=MN8TOARS.
    10.1021/jo800690m
  11. Nunes, P.M.; Estcio, S.G.; Lopes, G.T.; Costa Cabral, B.J.; Dos Santos, R.M.B.; Simes, J.A.M.. "C-H bond dissociation enthalpies in norbornane. An experimental and computational study". Organic Letters 10 8 (2008): 1613-1616. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449129116&partnerID=MN8TOARS.
    10.1021/ol800333q
  12. Agapito, F.; Nunes, P.M.; Cabral, B.J.C.; Dos Santos, R.M.B.; Simões, J.A.M.. "Energetics of the allyl group". Journal of Organic Chemistry 72 23 (2007): 8770-8779. http://www.scopus.com/inward/record.url?eid=2-s2.0-35948935559&partnerID=MN8TOARS.
    10.1021/jo701397r
  13. Borges Dos Santos, R.M.; Costa Cabral, B.J.; Martinho Simões, J.A.. "Bond-dissociation enthalpies in the gas phase and in organic solvents: Making ends meet". Pure and Applied Chemistry 79 8 (2007): 1369-1382. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547877558&partnerID=MN8TOARS.
    10.1351/pac200779081369
  14. Justino, G.C.; Correia, C.F.; Mira, L.; Borges Dos Santos, R.M.; Martinho Simões, J.A.; Silva, A.M.; Santos, C.; Gigante, B.. "Antioxidant activity of a catechol derived from abietic acid". Journal of Agricultural and Food Chemistry 54 2 (2006): 342-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644527574&partnerID=MN8TOARS.
    10.1021/jf052062k
  15. Nunes, P.M.; Correia, C.F.; Borges Dos Santos, R.M.; Martinho Simões, J.A.. "Time-resolved photoacoustic calorimetry as a tool to determine rate constants of hydrogen-abstraction reactions". International Journal of Chemical Kinetics 38 6 (2006): 357-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744483750&partnerID=MN8TOARS.
    10.1002/kin.20173
  16. Nunes, P.M.; Agapito, F.; Cabral, B.J.C.; Borges Dos Santos, R.M.; Martinho Simões, J.A.. "Enthalpy of formation of the cyclopentadienyl radical: Photoacoustic calorimetry and ab initio studies". Journal of Physical Chemistry A 110 15 (2006): 5130-5134. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646433961&partnerID=MN8TOARS.
    10.1021/jp060325n
  17. Correia, C.F.; Borges Dos Santos, R.M.; Estácio, S.G.; Telo, J.P.; Costa Cabral, B.J.; Martinho Simões, J.A.. "Reaction of para-hydroxy-substituted diphenylmethanes with tert-butoxy radical". ChemPhysChem 5 8 (2004): 1217-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544236322&partnerID=MN8TOARS.
    10.1002/cphc.200400044
  18. Correia, C.F.; Guedes, R.C.; Borges Dos Santos, R.M.; Costa Cabral, B.J.; Martinho Simões, J.A.. "O-H Bond dissociation enthalpies in hydroxyphenols. A time-resolved photoacoustic calorimetry and quantum chemistry study". Physical Chemistry Chemical Physics 6 9 (2004): 2109-2118. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942612988&partnerID=MN8TOARS.
    10.1039/b314093h
  19. Correia, C.F.; Nunes, P.M.; Borges Dos Santos, R.M.; Martinho Simões, J.A.. "Gas-phase energetics of organic free radicals using time-resolved photoacoustic calorimetry". Thermochimica Acta 420 1-2 SPEC. (2004): 3-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-4644316826&partnerID=MN8TOARS.
    10.1016/j.tca.2003.10.027
  20. Muralha, V.S.F.; Borges dos Santos, R.M.; Martinho Simões, J.A.. "Energetics of Alkylbenzyl Radicals: A Time-Resolved Photoacoustic Calorimetry Study". Journal of Physical Chemistry A 108 6 (2004): 936-942. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342281174&partnerID=MN8TOARS.
    10.1021/jp036293a
  21. Guedes, R.C.; Coutinho, K.; Costa Cabrai, B.J.; Canuto, S.; Correia, C.F.; Borges dos Santos, R.M.; Martinho Simões, J.A.. "Solvent Effects on the Energetics of the Phenol O-H Bond: Differential Solvation of Phenol and Phenoxy Radical in Benzene and Acetonitrile". Journal of Physical Chemistry A 107 43 (2003): 9197-9207. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242583947&partnerID=MN8TOARS.
    10.1021/jp035912c
  22. Dos Santos, R.M.B.; Muralha, V.S.F.; Correia, C.F.; Guedes, R.C.; Costa Cabral, B.J.; Simões, J.A.M.. "S-H bond dissociation enthalpies in thiophenols: A time-resolved photoacoustic calorimetry and quantum chemistry study". Journal of Physical Chemistry A 106 42 (2002): 9883-9889. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037168316&partnerID=MN8TOARS.
    10.1021/jp025677i
  23. Ribeiro Da Silva, M.A.V.; Matos, M.A.R.; Miranda, M.S.; Sousa, M.H.F.A.; Borges Dos Santos, R.M.; Bizarro, M.M.; Martinho Simões, J.A.. "Standard enthalpies of formation of 2,6-di-tert-butyl-4-methylphenol and 3,5-di-tert-butylphenol and their phenoxy radicals". Structural Chemistry 12 2 (2001): 171-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037618688&partnerID=MN8TOARS.
  24. Borges dos Santos, R.M.; Muralha, V.S.F.; Correia, C.F.; Martinho Simões, J.A.. "Solvation enthalpies of free radicals: O-O bond strength in Di-tert-butylperoxide". Journal of the American Chemical Society 123 50 (2001): 12670-12674. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035915334&partnerID=MN8TOARS.
    10.1021/ja010703w
  25. Borges Dos Santos, R.M.; Lagoa, A.L.C.; Martinho Simões, J.A.. "Photoacoustic calorimetry. An examination of a non-classical thermochemistry tool". Journal of Chemical Thermodynamics 31 11 (1999): 1483-1510. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001518103&partnerID=MN8TOARS.
    10.1006/jcht.1999.0513
  26. Bizarro, M.M.; Costa Cabral, B.J.; Borges Dos Santos, R.M.B.; Martinho Simões, J.A.. "Substituent effects on the O-H bond dissociation enthalpies in phenolic compounds: Agreements and controversies". Pure and Applied Chemistry 71 7 (1999): 1249-1256. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006895855&partnerID=MN8TOARS.
    10.1046/j.1365-3075.1999.00279.x
  27. Borges Dos Santos, R.M.; Martinho Simôes, J.A.. "Energetics of the O-H bond in phenol and substituted phenols: A critical evaluation of literature data". Journal of Physical and Chemical Reference Data 27 3 (1998): 707-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001161617&partnerID=MN8TOARS.
    10.1063/1.556020
  28. Borges, M.L.; Latterini, L.; Elisei, F.; Silva, P.F.; Borges, R.; Becker, R.S.; Maçanita, A.L.. "Photophysical Properties and Photobiological Activity of the Furanochromones Visnagin and Khellin". Photochemistry and Photobiology 67 2 (1998): 184-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031988939&partnerID=MN8TOARS.

Intellectual property

Patent
  1. Grenha, Ana; Pontes, Jorge F.; Borges dos Santos, Rui M.; Conceição, Eusebio; Diogo, Hermínio. 2024. "Portable device to study the exposure of cells to dry powders PCT/IB2022/06046". Portugal.
    Pending
Provisional application for patent
  1. 2022. "MICROBALANCE/CALORIMETER FLOW SENSOR (MCFS)".
    Protected
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/03 - 2023/05 Tese de Doutoramento intitulada "Study of the impact of dry powder insufflation over respiratory epithelial cells"
Co-supervisor
 Doutoramento em Medicina Regenerativa (PhD)
Universidade do Algarve, Portugal
2013/03/01 - 2020/05/15 Tese de doutoramento intitulada "Label free profiling of biomolecular interactions with coupled acoustic wave biosensor and heat conduction calorimetry"
Supervisor of Ana Catarina Pina Águas
 Ciências Biotecnológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2013/11/01 - 2014/06/30 Bolsa de pós-doutoramento ao abrigo do projeto "Thermochemistry of Oxygen Addition to Carbon-Centered Radicals" (PTDC/QUI-QUI/110542/2009)
Supervisor of Rui Jorge Centeno Santos
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2012/08/01 - 2012/12/31 Bolsa de pós-doutoramento ao abrigo do projeto "Thermodynamic Signature of the Pregnane Xenobiotic Receptor Activation by Quartz Crystal Microbalance with Heat Conduction Calorimetry" (PTDC/QUI/72631/2006)
Supervisor of Ana Isabel Moreira Cruz Lobo Ferreira
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2010/09/01 - 2012/09/30 Bolsa de pós-doutoramento individual SFRH/BPD/20836/2004
Supervisor of Tânia Vanessa Santos De Almeida
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2011/08/01 - 2012/01/31 Bolsa de pós-doutoramento ao abrigo do projeto "The stability of selected carbon-centered radicals and the antioxidant role of some terpenes" (PTDC/QUI/65535/2006)
Co-supervisor
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2005/09/01 - 2010/05/26 Tese de doutoramento intitulada "Theoretical Study of the Reactivity and Energetics of Organic Radicals"
Co-supervisor of Filipe Miguel Peres Agapito
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2002/01/01 - 2005/12/21 Tese de doutoramento intitulada "Energética da Ligação O-H em Compostos Fenólicos"
Co-supervisor of Ana Catarina Dias Filipe Pancada Correia
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2001/01/01 - 2005/01/13 Tese de doutoramento intitulada "Aplicação da Calorimetria Fotoacústica no Estudo da Energética de Moléculas"
Co-supervisor of Vânia Solange Ferreira Muralha
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal

Interview (tv / radio show)

Program Topic
2018/07/31 - 2018/07/31 90 segundos de ciência O que nos diz a voz da fotossíntese?
Distinctions

Award

2023 Prémio Boas Práticas da Universidade do Algarve - Boa Prática de Excelência
Universidade do Algarve, Portugal
2021 Mençao Honrosa - Prémio Ideias em Caixa
Ideias em Caixa - Caixa Geral de Depósitos /Universidade do Algarve, Portugal, Portugal
2014 10th European Symposium on Biochemical Engineering sciences - Best Poster Award
European Society of Biochemical Engineering Sciences, Belgium