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JORGE MANUEL DE SOUSA BELEZA. Concluiu o(a) Doutoramento em Biomedicina em 2022/04/05 pelo(a) Universitat de Barcelona Facultat de Biologia, Mestrado em 2º Ciclo em Atividade Física e Saúde em 2014 pelo(a) Universidade do Porto, Mestrado em Atividade Física e Saúde em 2014 pelo(a) Universidade do Porto Faculdade de Desporto e Licenciatura em Desporto e Lazer - Condição Física em 2011 pelo(a) Instituto Politécnico de Coimbra Escola Superior de Educação de Coimbra. É Professor Adjunto Convidado no(a) Instituto Politécnico de Viana do Castelo Escola Superior de Desporto e Lazer. Publicou 23 artigos em revistas especializadas. Possui 4 capítulo(s) de livros. Recebeu 1 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Investigação em 1 projeto(s) e Investigador em 5 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Ciências da Saúde com ênfase em Ciências do Desporto. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Ciências da Saúde, Ciências da saúde; Health sciences, Health sciences; Ciências médicas e da saúde::Ciências da saúde; Medical and Health sciences::Health sciences; Mitocôndria; Exercício; Gravidez; Diabetes; NAFLD; foetal programming; maternal exercise; offspring health; physical exercise; Female; Fetal Diseases; Humans; Non-alcoholic Fatty Liver Disease; Pregnancy; Exercise; Fetal programming; Gestational diabetes; Liver mitochondria; Physical activity; Pregnancy; Animals; Cell Respiration; Diabetes, Gestational; Dietary Carbohydrates; Lipid Metabolism; Liver; Male; Maternal Nutritional Physiological Phenomena; Mitochondria, Liver; Mothers; Physical Conditioning, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sucrose; Diet, High-Fat; Fetal Programming; Gestational Exercise; Physical Exercise; Doenças Genéticas; Ciências da saúde; Health sciences; BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle; Mitochondria; Maternal Exercise; Epigenetics; MicroRNAs; Genetics; Metabolic Diseases; Ciências sociais; Social sciences; early-life exercise; epigenetics; maternal exercise; offspring; paternal exercise; Epigenesis, Genetic; Growth; Muscle, Skeletal; gestational diabetes; mitochondrial biogenesis; mitochondrial dynamics; epigenetics; gestational exercise; foetal programming; Cardiac health post-pregnancy; Cardiac metabolic flexibility; Cardiac redox balance postpartum; Maternal cardiovascular ; cardiac remodelling; exercise cessation; female; high-fat high-sugar diet; metabolic dysfunction; mitochondria; .
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Identification

Personal identification

Full name
JORGE MANUEL DE SOUSA BELEZA

Citation names

  • Beleza, Jorge

Author identifiers

Ciência ID
171E-5363-B1B9
ORCID iD
0000-0002-7573-3757

Telephones

Telephone
  • 258809678 Ext.: 29115 (Professional)

Addresses

  • Escola Superior de Desporto e Lazer, Complexo Desportivo e de Lazer Comendador Rui Solheiro, , 4960-320, Melgaço, Melgaço, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Sport and Fitness Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Catalan Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016/10/24 - 2022/04/05
Concluded
 Biomedicina (Doutoramento)
Universitat de Barcelona Facultat de Biologia, Spain
2020/01/20 - 2020/01/23
Concluded
 O2k-Coaching Days - Basic 144th O2k-Workshop on high-resolution respirometry (Outros)
Oroboros Instruments, Austria
2019/08/19 - 2019/08/23
Concluded
 Mitochondrial Physiology – From Organelle to Organism (Outros)
IT-Universitet i København, Denmark
2019/07/08 - 2019/07/11
Concluded
 12th MiP/MitoEAGLE Training School 2019. “Mitochondrial respiratory physiology: Challenges on data sharing, reproducibility, and interpretation (Outros)
Universidade de Coimbra, Portugal
2017/09/18 - 2017/09/23
Concluded
 Tools and Rationale for Measuring Mitochondrial Funtion in Intact Cells and Isolates Mitochondria (Outros)
BIOCANT, Portugal
2017/08/21 - 2017/08/25
Concluded
 Mitochondrial Physiology – From Organelle to Organism (Outros)
IT-Universitet i København, Denmark
2016/09/12 - 2016/09/23
Concluded
 Course in Laboratory Animal Science (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 n/a
2014
Concluded
 2º Ciclo em Atividade Física e Saúde (Mestrado)
Universidade do Porto, Portugal
"Exercício físico e obesidade. Efeito da atividade física voluntária e do treino de endurance na funcionalidade de mitocôndrias do tecido adiposo." (THESIS/DISSERTATION)
 17 valores
2014
Concluded
 Atividade Física e Saúde (Mestrado)
Major in Sem especialização
Universidade do Porto Faculdade de Desporto, Portugal
"Exercício físico e obesidade. Efeito da atividade física voluntária e do treino de endurance na funcionalidade de mitocôndrias do tecido adiposo." (THESIS/DISSERTATION)
 17 valores
2013
Concluded
 Best practice in Childhood Physical Activity and Health (Outros)
Syddansk Universitet, Denmark
"Effects of physical activity on cognitive function associated with Peripheral Brain-Derived Neurotrophic factor in children" (THESIS/DISSERTATION)
 n/a
2011
Concluded
 Desporto e Lazer - Condição Física (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior de Educação de Coimbra, Portugal
"n/a" (THESIS/DISSERTATION)
 15 Valores
Affiliation

Science

Category
Host institution 		Employer
2018/07/01 - 2022/04/05 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Desporto, Portugal
2016/04/01 - 2022/04/05 Researcher (Research) Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
Universidade do Porto Faculdade de Desporto, Portugal
2020/01/20 - 2020/03/20 Visiting Researcher (Research) Oroboros Instruments, Austria
Oroboros Instruments, Austria
2016/04/01 - 2018/06/30 Researcher (Research) Universidade do Porto Faculdade de Desporto, Portugal
Universidade do Porto Faculdade de Desporto, Portugal
2016/06/01 - 2016/09/30 Visiting Researcher (Research) Universitat de Barcelona Facultat de Biologia, Spain
Universitat de Barcelona Facultat de Biologia, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2025/02/15 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Viana do Castelo Escola Superior de Desporto e Lazer, Portugal
2016/05/01 - Current Invited Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2024/02/15 - 2024/06/30 Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Viana do Castelo Escola Superior de Desporto e Lazer, Portugal
2019/03/01 - 2020/02/29 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Desporto, Portugal
Projects

Grant

Designation Funders
2018/07/01 - 2022/05/31 Are cardiac and brain epigenetic modifications induced by physical exercise transgenerationally inherited Focus on mitochondrial-related adaptations.
SFRH/BD/129645/2017
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2018/06/30 Exercising obesity: The role of exercise against endoplasmic reticulum stress in obesity-induced liver disease
FCT - PTDC/DTP-DES/7087/2014
Research Fellow
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
Concluded

Contract

Designation Funders
2016/01/01 - 2020/12/31 Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease – mitoFOIE GRAS
H2020-MSCA-RISE-2016-734719
Researcher
Ongoing
2016/01/01 - 2020/12/31 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
H2020-MSCA-ITN-2016-722619
Researcher
Ongoing
2016/09/01 - 2020/08/31 Mitochondrial mapping: Evolution - Age - Gender - Lifestyle – Environment (MitoEAGLE)
Horizon 2020 COST Action (CA15203)
Researcher
Ongoing
2016/04/01 - 2019/09/30 Exercising the future: Voluntary exercise during gestational diabetes as a means to improve mitochondrial function in the offspring
FCT - PTDC/DTP-DES/1082/2014
Researcher
Concluded
2016/04/01 - 2019/09/30 EXERCITANDO O FUTURO: Exercício Voluntário Durante Diabetes Gestacional com uma Estratégia para Melhorar a Função Mitocondrial na Descendência
PTDC/DTP-DES/1082/2014
Universidade do Porto Faculdade de Desporto, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2015/12/31 Red Iberoamericana de Medicina y Fisiología de Altura
ALTMEDFIS (CYTED)
Researcher
Universitat de Barcelona Facultat de Biologia, Spain
Ongoing
Outputs

Publications

Book chapter
  1. Beleza, Jorge; Gonçalves, Carla. "La Importancia del Ejercicio Físico". In Seguridad y Primeiros Auxilios en Barrancos, 85-87. Madrid, Spain: Desnível, 2025.
    Published
  2. Beleza, Jorge. "Modulatory impact of physical exercise on white adipose tissue’s morphological and metabolic features: systemic and local-derived mechanisms.". In Recent Advances in Obesity: Understanding Obesity – From its Origins to Impact on Life. 2022.
    Published
  3. Beleza, Jorge. "Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity". 2018.
    10.1007/978-3-319-73344-9_18
  4. Beleza, Jorge. "Exercise, Liver Steatosis, and Free Radicals". 2017.
    10.1016/b978-0-12-804274-8.00024-2
Conference abstract
  1. Beleza, Jorge. "Modulation of visceral adipose tissue through exercise in obese animals: analysis of oxidative and apoptotic signalling markers". 2014.
  2. Beleza, Jorge. "Endurance training reduces high-fat diet-induced up-regulation of apoptotic signaling in visceral adipose tissue from obese animals". 2014.
  3. Beleza, Jorge. "Voluntary physical activity differently regulates Bcl-2-related apoptosis signaling in different visceral adipose tissue depots from obese animals". 2014.
    DOI: 10.1111/eci.12257
Conference poster
  1. Grilo, Luís F.; Pedro Valente; Jelena Stevanovic-Silva; Beleza, Jorge; José Magalhães; Oliveira, Paulo J.; Susana P. Pereira. "Untargeted FTIR-Based Blood Screening Reveals Plasma Aging Signatures in Offspring of Obese Mothers". Paper presented in 59th ESCI Annual scientific meeting, 2025.
  2. Grilo, Luís F.; Pedro Valente; Jelena Stevanovic-Silva; Beleza, Jorge; António Ascensão; José Magalhães; Oliveira, Paulo J.; Susana P Pereira. "Sex- and Age-Dependent Impact of Maternal Obesity on Offspring Blood Composition in Untargeted FTIR Screening.". Paper presented in V Metabolism, Ageing & Disease (MAD) Meeting - From prevention to personalized medicine: empowering the citizen, 2025.
Journal article
  1. Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; et al. Corresponding author: Pereira, Susana P.. "Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1871 1 (2024): 167539. https://hdl.handle.net/10316/116908.
    Published • 10.1016/j.bbadis.2024.167539
  2. Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M.; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; et al. Corresponding author: Pereira, Susana P.. "Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation". European Journal of Clinical Investigation 53 11 (2023): http://dx.doi.org/10.1111/eci.14069.
    10.1111/eci.14069
  3. Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Oliveira, Paulo J.; Ascensão, António; Magalhães, José. "Gestational Exercise Antagonises the Impact of Maternal High-Fat High-Sucrose Diet on Liver Mitochondrial Alterations and Quality Control Signalling in Male Offspring". (2023): https://hdl.handle.net/10316/114911.
    https://doi.org/10.3390/ijerph20021388
  4. Ana Margarida Lopes; Manoel Rios; Jorge Beleza; Diogo Duarte Carvalho; Sofia Monteiro; Tiago Montanha; Sandra Martins; et al. "Adding protein to a carbohydrate pre-exercise beverage does not influence running performance and metabolism". (2023): https://hdl.handle.net/10216/144363.
    10.23736/S0022-4707.22.13714-X
  5. Bonet, Jèssica B.; Javierre, Casimiro; Guimarães, João Tiago; Martins, Sandra; Rizo-Roca, David; Beleza, Jorge; Viscor, Ginés; et al. "Benefits on Hematological and Biochemical Parameters of a High-Intensity Interval Training Program for a Half-Marathon in Recreational Middle-Aged Women Runners". International Journal of Environmental Research and Public Health 19 1 (2022): 498. http://dx.doi.org/10.3390/ijerph19010498.
    Published • 10.3390/ijerph19010498
  6. Beleza, Jorge; Stevanovic-Silva, Jelena; Coxito, Pedro; Rocha, Hugo; Santos, Paulo; Ascensão, António; Ramon Torrella, Joan; Magalhães, José. "Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early in Life". (2022): http://hdl.handle.net/10400.18/8547.
    10.3390/ijms23073916
  7. Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Magalhães, José. "Fit mothers for a healthy future: Breaking the intergenerational cycle of non-alcoholic fatty liver disease with maternal exercise". (2022): https://hdl.handle.net/10316/104002.
    https://doi.org/10.1111/eci.13596
  8. Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, Rossana; et al. "Exercise performed during pregnancy positively modulates liver metabolism and promotes mitochondrial biogenesis of female offspring in a rat model of diet-induced gestational diabetes". (2022): http://hdl.handle.net/10400.18/8575.
    10.1016/j.bbadis.2022.166526
  9. Manoel Rios; Tamires Macan; Jelena Stevanovic-Silva; Kamonrat Nhusawi; Ricardo J. Fernandes; Jorge Beleza; António Ascensão; José Magalhães. "Acute CrossFit® Workout Session Impacts Blood Redox Marker Modulation". Physiologia (2021): https://www.mdpi.com/2673-9488/1/1/4.
    10.3390/physiologia1010004
  10. Beleza, Jorge; Stevanovic-Silva, Jelena; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Torrella, Joan Ramon; Magalhães, José. "Building-up fit muscles for the future". European Journal of Clinical Investigation (2021): http://dx.doi.org/10.1111/eci.13515.
    10.1111/eci.13515
  11. Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Pereira, Susana; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; et al. "Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring". Metabolism 116 (2021): 154704. http://dx.doi.org/10.1016/j.metabol.2021.154704.
    10.1016/j.metabol.2021.154704
  12. Beleza, Jorge; Stevanovic-Silva, Jelena; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Torrella, Joan Ramon; Magalhães, José. "Building-up fit muscles for the future: Transgenerational programming of skeletal muscle through physical exercise". (2021): https://hdl.handle.net/10316/104030.
    https://doi.org/10.1111/eci.13515
  13. Marques-Aleixo I; Beleza J; Sampaio A; Stevanovic J; Coxito P; Gonçalves I; Ascensão A; et al. "Preventive and therapeutic potential of physical exercise in neurodegenerative diseases.". Antioxidants & redox signaling (2020): http://europepmc.org/abstract/med/32159378.
    10.1089/ars.2020.8075
  14. Beleza, Jorge. "Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction". Acta Physiologica (2020): http://dx.doi.org/10.1111/apha.13378.
    10.1111/apha.13378
  15. Beleza, Jorge. "Mitochondrial physiology". Bioenergetics Communications (2020): https://www.bioenergetics-communications.org/index.php/bec/article/view/gnaiger_2020_mitophysiology/1.
  16. Bernardo TC; Beleza J; Rizo-Roca D; Santos-Alves E; Leal C; Martins MJ; Ascensão A; Magalhães J. "Physical exercise mitigates behavioral impairments in a rat model of sporadic Alzheimer's disease.". Behavioural brain research (2019): http://europepmc.org/abstract/med/31733314.
    10.1016/j.bbr.2019.112358
  17. Stevanovic J; Beleza J; Coxito P; Ascensão A; Magalhães J. "Physical exercise and liver "fitness": Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease.". Molecular metabolism (2019): http://europepmc.org/abstract/med/32029220.
    10.1016/j.molmet.2019.11.015
  18. Beleza, Jorge. "Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats’ Functional, Physiological, Biochemical, and Morphological Features". Frontiers in Physiology (2019): http://dx.doi.org/10.3389/fphys.2019.00593.
    10.3389/fphys.2019.00593
  19. Beleza, Jorge. "Physical exercise mitigates high-fat diet-induced adiposopathy and related endocrine alterations in an animal model of obesity.". Journal of physiology and biochemistry (2018): https://doi.org/10.1007/s13105-018-0609-1.
    10.1007/s13105-018-0609-1
  20. Beleza, Jorge. "Effects of endurance training on autophagy and apoptotic signaling in visceral adipose tissue of prolonged high fat diet-fed rats.". European journal of nutrition (2017): https://doi.org/10.1007/s00394-017-1500-5.
    10.1007/s00394-017-1500-5
  21. Beleza, Jorge. "Physical exercise remodels visceral adipose tissue and mitochondrial lipid metabolism in rats fed a high-fat diet.". Clinical and experimental pharmacology & physiology (2017): https://doi.org/10.1111/1440-1681.12706.
    10.1111/1440-1681.12706
  22. Beleza, Jorge. "Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease.". Brain pathology (Zurich, Switzerland) (2016): https://doi.org/10.1111/bpa.12403.
    10.1111/bpa.12403
  23. Sílvia Rocha-Rodrigues; Amaia Rodríguez; Alexandra M. Gouveia; Inês O. Gonçalves; Sara Becerril; Beatriz Ramírez; Jorge Beleza; et al. "Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet". Aims: Exercise-stimulated myokine secretion into circulation may be related with browning in white adipose tissue (WAT), representing a positive metabolic effect on whole-body fat mass. However, limited information is yet available regarding the impact of exercise on myokine-related modulation of adipocyte phenotype in WAT from obese rats.Main methods: Sprague-Dawley rats (n = 60) were divided int (2016): https://hdl.handle.net/10216/88411.
    10.1016/j.lfs.2016.09.023
Thesis / Dissertation
  1. Jorge Manuel de Sousa Beleza. "Exercício físico e obesidade. Efeito da atividade física voluntária e do treino de endurance na funcionalidade de mitocôndrias do tecido adiposo.". Master, 2014. https://hdl.handle.net/10216/77024.
Website
  1. Beleza, Jorge. Mitochondrial respiratory states and rates. 2020. https://www.mitoeagle.org/images/archive/d/d1/20190712073204%21Gnaiger_2019_MitoFit_Preprint_Arch_doi_10.26124_mitofit_190001.v5%28in_prep%29.pdf.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/23 Exercise performed during pregnancy as a preventive tool against transgenerational development of diabetes mellitus and NAFLD in the offspring MitoFit Open Seminars
(Innsbruck, Austria)
2019/10/23 Adaptações Fisiológicas à altitude e estratégias de aclimatação 3 Encontro Multidisciplinar de Montanha - Mizarelar
(Arouca, Portugal)
2019/07/27 Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function MiPschool Coimbra
(Coimbra, Portugal)
2019/07/04 Comparison between skeletal muscle adaptations to free-running wheel and high-intensity interval training 24th Congress of the European College of Sport Sciencey
(Prague, Czech Republic)
2018/07/03 Comparison between cardiac functional mitochondrial adaptations to free running wheel and high intensity interval training. 23th Congress of the European College of Sport Science
(Dublin, Ireland)
2015/05/04 Exercise and obesity. The influence of voluntary physical activity and endurance training in adipose tissue mitochondria functionality 8th Meeting of Young Researchers of the University of Porto
(Porto, Portugal)
2014/05/09 Modulation of visceral adipose tissue through exercise in obese animals: analysis of oxidative and apoptotic signalling markers 7th Meeting of Young Researchers of the University of Porto
(Porto, Portugal)
Distinctions

Award

2019 Best poster, Mitochondria - 53th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation, Netherlands