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Maria Luísa Serralheiro degree in Chemistry (1980), Faculdade de Ciências da Universidade de Lisboa, MSc Biotecnology (1990), PhD Biochemistry (1997) University of Lisbon; Habilitation in Biochemistry (Biotechnology) (2013). Jury in COST evaluation Programm, PhD and MSc thesis. PI in research projects from Portuguese Science and Technology Foundation (FCT) on Hypercholesterolemia reduction with functional foods. Co-Coordination of: Research Center (2014-2016); Biochemistry Degree (2007-2009); MSc in Biochemistry (2009-2011); PhD Biochemistry (2015-2018); Biochemistry ERASMUS (2008-till present). Supervised: 8 PhD (3 going-on); 28 MSc; 14 Biochemistry degrees thesis. Published: 89 papers in inter. journals with rev., 70 communications in int. congresses; 2 National Patents, 3 awards.h=20.
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Identification

Personal identification

Full name
Maria Luisa Mourato de OLiveira Marques Serralheiro

Citation names

  • Serralheiro, Maria

Author identifiers

Ciência ID
161C-CC25-6122

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2013
Concluded
 Agregação (Título de Agregado)
Universidade de Lisboa, Portugal
"n/a" (THESIS/DISSERTATION)
 n/a
1997
Concluded
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudos de Actividade e Estabilidade de a-Quimotripsina em Micelas Invertidas para Síntese de Dipépt" (THESIS/DISSERTATION)
 Muito Bom com Distinção e Louvor
1990
Concluded
 Biotecnologia (Engenharia Bioquimica) (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Síntese de Péptidos em Sistemas Multifásicos" (THESIS/DISSERTATION)
 Muito Bom
1980
Concluded
 Química (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
1980/12/06 - 1986/04/01 Research Assistant (Research) Laboratorio Nacional de Engenharia e Tecnologia Industrial, Portugal
1980/12/06 - 1986/04/01 Research Assistant (Research) Laboratorio Nacional de Engenharia e Tecnologia Industrial, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/09/08 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
1997/02/01 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2023 Assistant Professor (University Teacher) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2007 - 2017/07 Assistant Professor (University Teacher) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
1997/02/01 - 2013/02/01 Assistant (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2013 Assistant Professor (University Teacher) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
1990/02/01 - 1997/02/01 Assistant (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2013/02/01 - Current Assistant professor with Habilitation Universidade de Lisboa Faculdade de Ciências, Portugal
1986/04/01 - 1990/01/01 Laboratory Assistant Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2018/09/02 - 2021/12/31 BioMol4Health-Molecules for Health: cholesterol absorption, and exprtession of its transporter proteins, intercations with drugs
PTDC/BIA-BQM/28355/2017
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2011/01/02 - 2013/12/31 RACHIs - Reduction on the Absorption of Cholesterol by Herbal Infusions (Functional Foods
PTDC/QUI-BIQ/113477/2009
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/02 - 2008/12/31 Biodegradation of Azo Dyes in a Sequencing Batch Reactor
32586/99- FCT/Sapiens 99
Researcher
Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Serralheiro, Maria. "Influence of Long Chain Alcohols and Chemical Modification on the Microencapsulated ¿-Chymotrypsin Stability". In Stability and Stabilization of Enzymes., 481-488. Netherlands: Elsevier, 1993.
    Published
  2. Serralheiro, Maria. "Application of Fraccional Factorial Design to the Study of Enzymatic Dipeptide Synthesis in Reverse Micelles". In Biocatalysis in non-conventional media, 725-732. Netherlands: Elsevier, 1992.
    Published
Conference poster
  1. Serralheiro, Maria. "Activity of fucus vesiculosus (bodelha) from the tagus estuary (lisbon, portugal) as antiacetilcolinesterase and antioxidant". Paper presented in XVI MaNaPro & XI ECMNP, 2019.
  2. Serralheiro, Maria. "Centaurium erythraea decoctions with antiHMGR activities: a good source of hypocholesterolemic drugs". Paper presented in Natural Products in Drug Descovery and Human Health,, 2019.
  3. Serralheiro, Maria. "Effect of fucus vesiculosus water extracts on the anti-acetylcholinesterase activity: a promising source of natural drugs". Paper presented in Natural Products in Drug Descovery and Human Health, 2019.
  4. Serralheiro, Maria. "EuMELANIN: A brownish melanin form Pseudomonas putida with bioactivity". Paper presented in Natural Products in Drug Descovery and Human Health, 2019.
  5. Serralheiro, Maria. "Bioactivity of Fucus vesiculosus (bodelha) from the Tagus estuary (Lisbon, Portugal): correlation with thallus age and genre.". Paper presented in XXII Symposium of Cryptogamic Botany, 2019.
  6. Serralheiro, Maria. "Wakame: total phenolic content extraction before and after gastro-intestinal in vitro digestion.". Paper presented in 9th International Conference on Algal Biomass Biofules and Bioproducts, 2019.
  7. Serralheiro, Maria. "Recovery of bioactive compounds from Fucus vesiculosus algae by membrane technology and evaluation of biological action against cardiovascular diseases". Paper presented in XX EuroFoodChem, 2019.
  8. Serralheiro, Maria. "Beta Vulgaris L. leaves and stalks - Separation and purification of bioactive compounds using membrane technology". Paper presented in XX EuroFoodChem, 2019.
  9. Serralheiro, Maria. "Study of antioxidant and antitumoral activity of cork processing wastewaters components fractionated by ultrafiltration membranes". Paper presented in AICOM, 2017.
  10. Serralheiro, Maria. "«In vitro hypocholesterolemic effect of aqueous extracts from leaves of Vernonia condensata (Asteraceae)". Paper presented in CIPAM, 6th International Congress of Aromatic and Medicinal Plants, 2016.
  11. Serralheiro, Maria. "Study of the permeability of phenolic compounds present in cladodes of Opuntia ficus indica and their effect on the cholesterol permeability through caco-2 cell lines". Paper presented in CIPAM, 6th International Congress of Aromatic and Medicinal Plants, 2016.
  12. Serralheiro, Maria. "Phenolic Compounds from herbal infusions in the prevention of age-related diseases (atherosclerosis and Alzheimer). Falé PL, Florêncio MH, Serralheiro ML". Paper presented in 2nd International Conference and Exhibition on Pharmacology and Ethnopharmacology, 2016.
  13. Serralheiro, Maria. "The effect of P. barbatus and P. zuluensis infusions on protein secondary structure investigated using FTIR spectroscopy". Paper presented in Advanced Vibrational Spectroscopy for Biomedical Applications: Faraday Discussion, 2016.
  14. Serralheiro, Maria. "Acetylcholinesterase inhibition, antioxidant activity, in vitro gastrointestinal digestion and toxicity of cladodes of Opuntia Ficus Indica extracts on HepG2, MCF-7 and caco-2 cell lines»". Paper presented in 2nd International Conference on Natural Product utilization, 2015.
  15. Serralheiro, Maria. "Activities of Plant Aqueous Extracts Against Herpes Simplex Virus Type 2". Paper presented in Microscopy at the Frontiers of Science, 2015.
  16. Serralheiro, Maria. "Antiacetylcholinesterase and antioxidant activities of several Plectranthus species". Paper presented in 19th Internacional Congresso n Organic Chemistry, 2015.
  17. Serralheiro, Maria. "Glandular trichomes and biological activities in Helichrysum italicum and H. stoechas, two Asteraceae species growing wild in Portugal". Paper presented in International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portugues Microcoscopy Society, 2014.
  18. Serralheiro, Maria. "Antibacterial effect of 7a-acetoxy-6ß-hidroxyroyleanone from Plectranthus grandidentatus". Paper presented in International Conference on Antimicrobial Research, 2014.
  19. Serralheiro, Maria. "Santolina impressa, a Portuguese endemic species: Inhibition of acetylcholinesterase, antioxidant activity and cell toxicity". Paper presented in 62nd International Congress and Annual Meeting of the Society of Medicinal Plants and Natural Products Research, 2014.
  20. Serralheiro, Maria. "Fraxinus angustifolia in the reduction of high cholesterol levels: does is work? is it safe?»". Paper presented in International Conference on Natural Products Utilization. From Plants to Pharmacy Shelf, ICNPU, 2013.
  21. Serralheiro, Maria. "Activities of Annona cherimolla extracts and its main components in the inhibition of acetylcholinesterase and HMG-CoA reductase". Paper presented in International Conference on Natural Products Utilization. From Plants to Pharmacy Shelf, ICNPU, 2013.
  22. Serralheiro, Maria. "Infusions of Peumus boldus, Fraxinus angustifolia, Cynara cardunculus Pterospartum tridentatum, and Annona cherimolla, are they appropriate for reducing serum cholesterol level?". Paper presented in nternational Conference on Natural Products Utilization. From Plants to Pharmacy Shelf, ICNPU, 2013.
  23. Serralheiro, Maria. "Biological Activities of Vernonia condensata: Acetylcholinesterase Inhibition and Caco-2 Cells Toxicity". Paper presented in 10º Encontro Nacional de Química Orgânica e 1º Encontro Luso-brasileiro de Química Orgânic, 2013.
  24. Serralheiro, Maria. "Inhibition of intestinal permeation of cholesterol by Peumus boldus decoction". Paper presented in International Conference on Natural Products Utilization. From Plants to Pharmacy Shelf, ICNPU, 2013.
  25. Serralheiro, Maria. "Activities of “carqueja” infusions in the gastrointestinal tract: facilitating the digestion and decreasing cholesterol absorption". Paper presented in 1st Mediterranean Symposium on Medicinal and Aromatic Plants, 2013.
  26. Serralheiro, Maria. "Biocatalysis of hydroxamic acids by immobilized Pseudomonas aeruginosa cells". Paper presented in 6th International Congress on Biocatalysis, 2012.
  27. Serralheiro, Maria. "Acetylcholinesterase Immobilization on Multiwell Plates". Paper presented in 9th International Conference on Protein Stabilisation, 2012.
  28. Serralheiro, Maria. "Gastrointestinal Simulated Digestion of the Peumus Boldus Infusion-Polyphenols". Paper presented in 5th International Conference on Polyphenols and Health, 2011.
  29. Serralheiro, Maria. "Acetylcholinesterase Inhibition by an Olive Pomace Extract Rich In Hydroxytyrosol". Paper presented in 5th International Conference on Polyphenols and Health, 2011.
  30. Serralheiro, Maria. "Gastrointestinal Simulated Digestion of the Cynara cardunculus (Artichoke) and Fraxinus angustifolia (Ash) Infusions". Paper presented in International Symposium on Health Benefits of Food-From Emerging Science to Innovative Products, 2011.
  31. Serralheiro, Maria. "Acetylcholinesterase Inhibition and Antioxidant Activity of Three Asteraceae Species From The Portuguese Aromatic Flora". Paper presented in International Symposium on Phytochemicals in Health and Nutrition, 2011.
  32. Serralheiro, Maria. "Activity of Plectranthus barbatus Extract Against Inflammatory Response In Human Neutrophils". Paper presented in International Symposium on Phytochemicals in Health and Nutrition, 2011.
  33. Serralheiro, Maria. "Biological Activity of Foeniculum vulgare and Geranium robertianum Herbal Teas After in vitro Gastrolintestinal Metabolism". Paper presented in International Society for Nutraceuticals and functional Foods, 2010.
  34. Serralheiro, Maria. "Brain Acetylcholinesterase Inhibition by Plectranthus Barbatus Herbal Tea". Paper presented in 11th Congress of the International Society for Ethnopharmacology (ISE 2010), 2010.
  35. Serralheiro, Maria. "Actividade Antioxidante e Antiacetilcolinesterase de Artemisia campestris e Helichrysum stoechas da flora portuguesa". Paper presented in 1er Encuentro Hispano Portugués de Etnobiología (EHPE 2010) / I Encontro Hispano – Português de Etnobiologia (EHPE 2010), 2010.
  36. Serralheiro, Maria. "Digestion of Plectranthus barbatus Decoction: Citotoxicity, in vitro Metabolism and the Remaining Antiacetylcholinesterase and Antioxidant Activities". Paper presented in Functional Molecules from Natural Sources, 2009.
  37. Serralheiro, Maria. "Multitarget Approaches for Treatment of Neurodegenerative Diseases: Design, Synthesis of Anti-Oxidant Phenolic Derivatives as Acetylcholinesterase Inhibitors". Paper presented in 9th International conference on Alzheimer´s and Parkinson Diseases, 2009.
  38. Serralheiro, Maria. "Acetylcholinesterase Inhibition by Rosmarinic Acid from Plectranthus species". Paper presented in 7th Joint Meeting of AFERP, GA, PSE & SIF. Natural products with Pharmaceutical, Nutraceutical Cosmetic and Agrochemical Interest, 2008.
  39. Serralheiro, Maria. "Investigation of Antioxidant, Acetylcholinesterase and Antimicrobial Activities of TOF and Decoction Extracts of Cybopogon schoenanthus L. (POACEAE". Paper presented in 3eme Symposium International sur les Plantes Aromatiques et Medicinales. 1ere Congres International sur les Molécules Bioactives, 2008.
  40. Serralheiro, Maria. "Antibacterial Activity of the Essential Oil of Cybopogon schoenanthus L. from Tunisia". Paper presented in International Symposium on Biotechnology, 2008.
  41. Serralheiro, Maria. "GC/MS and 13CNMR of Essential oils from Tunisiain Cymbopogon schoenanthus L. Spreng. Antioxidant and Anticolinesterase Activities". Paper presented in 41st IUPAC World Chemistry Congress, 2007.
  42. Serralheiro, Maria. "Investigation of Antioxidant Activity of TOF and Decoctions form (Tunisian) Cymbopogon schoenanthus L. Spreng". Paper presented in 6Th AFMC International medicinal Chemistry Symposium, 2007.
  43. Serralheiro, Maria. "Screening of the Plectranthus Species for Antioxidant Activity". Paper presented in Medicinal Chemistry in the 21st Century, 2006.
  44. Serralheiro, Maria. "Aminoisoxazole Cabamate as Cystein Proteases Inhibitor". Paper presented in Medicinal Chemistry in the 21st century, 2006.
  45. Serralheiro, Maria. "Antioxidant Activity and Acetylcholinesterase Inhibition Properties of Aromatic Herbs Used in Portuguese Diet". Paper presented in 1st European Chemistry Congress, 2006.
  46. Serralheiro, Maria. "Acetylcholinesterase Inhibition by Portuguese Medicinal Plants". Paper presented in 53rd Annual Congress of the Society for Medicinal Plant Research,, 2005.
  47. Serralheiro, Maria. "Synthesis of Hydroxamic Acid in TTAB Reversed Micelles using Amidase from Pseudomonas sp.". Paper presented in CERC3 YOUNG CHEMISTS’ WORKSHOPS, Biocatalysis,, 2004.
  48. Serralheiro, Maria. "Application of Fourier-Transform Infrared Spectroscopy for Monitoring Several Amidase Reactions". Paper presented in Second International Conference on Biomedical Spectroscopy: From the Bench to the Clinic, 2003.
  49. Serralheiro, Maria. "A FTIR Spectroscopic Based Method for Measuring Enzymatic Activity of a Recombinant Amidase". Paper presented in First International Conference on Biomedical Spectroscopy: From Molecules to men, 2002.
  50. Serralheiro, Maria. "Effect of Enzymatic Degradation of Cross Linked (2-Hydroxypropyl) Cellulose (HPC) Solid Films on their Optical Properties". Paper presented in 11th European Carbohydrate Symposium-EOROCARB XI., 2001.
  51. Serralheiro, Maria. "Development of a New Polysulphone Immobilized Tyrosinase Biosensor with Amperometric Detection". Paper presented in 51st ISE Meeting: Electrochemistry at the Turn of the Millenium, 2000.
  52. Serralheiro, Maria. "Substitution of Trp-138 by Gly or Ser in Amidase from Pseudomonas aeruginosa is Responsible for Alteration in Enzyme Stability". Paper presented in 2nd International Conference on Protein Stabilization, 2000.
  53. Serralheiro, Maria. "Substitution of Trp-138 by Gly or Ser in amidase from Pseudomonas aeruginosa is Responsible for Alteration in Enzyme Stability". Paper presented in 2nd International Conference on Protein Stabilization. Biomolecule stabilisation From Molecular Interpretations to Bio-Industrial Applications, 2000.
  54. Serralheiro, Maria. "Irreversible Thermoinactivation Process of ¿-Chymotrypsin in Aqueous and Organic Media". Paper presented in 1ª Conferência Internacional sobre Estabilização de Proteínas, 1998.
  55. Serralheiro, Maria. "Application of Fractional Factorial Design to the Study of Cutinase Stability in Reversed Micelles of AOT: Optimization of the System". Paper presented in Congresso Luso-Espanhol, 1996.
  56. Serralheiro, Maria. "Transesterification Reactions by a Recombinant Cutinase in Reversed Micelles". Paper presented in BIOTRANS-95, 1995.
  57. Serralheiro, Maria. "Continuous Production of AcPheLeuNH2 by ¿-Chymotrypsin in a Reversed Micellar Membrane Reactor". Paper presented in 1º Congresso Europeu de Biotecnologia, 1995.
  58. Serralheiro, Maria. "Process Integration in the Enzymatic Synthesis of Dipeptide in Organic Solvents”. Prazeres DMF,". Paper presented in Les Enzymes dans L’Industrie Alimentaire/Enzymes For Food Processing, 1995.
  59. Serralheiro, Maria. "Peptide Synthesis Catalysed by Microencapsulated ¿-Chymotrypsin in a Membrane Bioreactor". Paper presented in Simpósio Internacional sobre Biocatalysis, 1993.
  60. Serralheiro, Maria. "Influence of Long Chain Alcohols and Chemical Modification on the Microencapsulated ¿-Chymotrypsin Stability". Paper presented in Stability and stabilization of enzymes, 1992.
  61. Serralheiro, Maria. "Application of Fraccional Factorial Design to the Study of Enzymatic Dipeptide Synthesis in Reverse Micelles". Paper presented in Biocatalysis in non-conventional media, 1992.
  62. Serralheiro, Maria. "Stability of ¿-Chymotrypsin in Reverse Micellar Systems". Paper presented in Stability of Protein: Theory and Practice, 1990.
  63. Serralheiro, Maria. "Rapid Thin Layer Chromatographic Determination of Aflatoxin M1 in Milk". Paper presented in 6º Simpósio Internacional sobre Mycotoxins and Phycotoxins, 1985.
  64. Serralheiro, Maria. "Determinação de Patulina, Acido Penicílico e Citrinina em Produtos Derivados de Fruta". Paper presented in Reunião de Micologia. na Universidade de Alcalá de Henares, Madrid, 1982.
  65. Serralheiro, Maria. "Métodos de Detecção de Aflatoxina B1, B2, G1, G2, Citrinina, Ocratoxina A e Ácido Penicílico em Pimenta". Paper presented in 1ª Reunião de Micologia, 1982.
Journal article
  1. Lorena, Constança; Ressaissi, Asma; Serralheiro, Maria Luísa. "Bioactives from Psidium guajava leaf decoction: LC-HRMS-MS-Qtof identification, bioactivities and bioavailability evaluation". Food Chemistry Advances 1 (2022): 100003. http://dx.doi.org/10.1016/j.focha.2021.100003.
    10.1016/j.focha.2021.100003
  2. Nunes, Diogo; André, Rebeca; Ressaissi, Asma; Duarte, Bernardo; Melo, Ricardo; Serralheiro, Maria Luísa. "Influence of Gender and Age of Brown Seaweed (Fucus vesiculosus) on Biochemical Activities of Its Aqueous Extracts". Foods 11 1 (2021): 39. http://dx.doi.org/10.3390/foods11010039.
    10.3390/foods11010039
  3. Ferraz, Ana Rita; Pacheco, Rita; Vaz, Pedro D.; Pintado, Cristina S.; Ascensão, Lia; Serralheiro, Maria Luisa. "Melanin: Production from Cheese Bacteria, Chemical Characterization, and Biological Activities". International Journal of Environmental Research and Public Health 18 20 (2021): 10562. http://dx.doi.org/10.3390/ijerph182010562.
    10.3390/ijerph182010562
  4. Ressaissi, Asma; Pacheco, Rita; Serralheiro, Maria Luísa M.. "Molecular-level changes induced by hydroxycinnamic acid derivatives in HepG2 cell line: Comparison with pravastatin". Life Sciences 283 (2021): 119846. http://dx.doi.org/10.1016/j.lfs.2021.119846.
    10.1016/j.lfs.2021.119846
  5. Berkani, Farida; Serralheiro, Maria Luísa; Dahmoune, Farid; Mahdjoub, Malik; Kadri, Nabil; Dairi, Sofiane; Achat, Sabiha; et al. "Ziziphus lotus (L.) Lam. plant treatment by ultrasounds and microwaves to improve antioxidants yield and quality: An overview". The North African Journal of Food and Nutrition Research 5 12 (2021): 53-68. http://dx.doi.org/10.51745/najfnr.5.12.53-68.
    10.51745/najfnr.5.12.53-68
  6. André, Rebeca; Pacheco, Rita; Bourbon, Mafalda; Serralheiro, Maria Luísa. "Brown Algae Potential as a Functional Food against Hypercholesterolemia: Review". Foods 10 2 (2021): 234. http://dx.doi.org/10.3390/foods10020234.
    Published • 10.3390/foods10020234
  7. Serralheiro, Maria; Berkani, Farida; Dahmoune, Farid; Serralheiro, Maria Luísa; Ressaissi, Asma; Dairi, Sofiane; Kadri, Nabil; et al. "New bioactive constituents characterized by LC-MS/MS in optimized microwave extract of jujube seeds (Zizyphus lotus L.).". Journal of Food Measurement and Characterization 15 4 (2021): 3216-3233. http://dx.doi.org/10.1007/s11694-021-00903-z.
    Under revision • 10.1007/s11694-021-00903-z
  8. Silva, André Filipe C.; Haris, Parvez I.; Serralheiro, Maria Luísa; Pacheco, Rita. "Mechanism of action and the biological activities of Nigella sativa oil components". Food Bioscience 38 (2020): 100783. http://dx.doi.org/10.1016/j.fbio.2020.100783.
    Published • 10.1016/j.fbio.2020.100783
  9. Mejri, Faiza; Baati, Tarek; Martins, Alice; Selmi, Slimen; Luisa Serralheiro, Maria; Falé, Pedro L.; Rauter, Amelia; Casabianca, Herve; Hosni, Karim. "Phytochemical analysis and in vitro and in vivo evaluation of biological activities of artichoke (Cynara scolymus L.) floral stems: Towards the valorization of food by-products". Food Chemistry 333 (2020): 127506. http://dx.doi.org/10.1016/j.foodchem.2020.127506.
    Published • 10.1016/j.foodchem.2020.127506
  10. Berkani, Farida; Serralheiro, Maria Luisa; Dahmoune, Farid; Ressaissi, Asma; Kadri, Nabil; Remini, Hocine. "Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities". Processes 8 11 (2020): 1441. http://dx.doi.org/10.3390/pr8111441.
    Published • 10.3390/pr8111441
  11. Serralheiro, Maria Luísa; Guedes, Rita; Fadel, Sezan R.; Bendif, Hamdi. "Data on identification of primary and secondary metabolites in aqueous extract of Verbascum betonicifolium". Data in Brief 32 (2020): 106146. http://dx.doi.org/10.1016/j.dib.2020.106146.
    10.1016/j.dib.2020.106146
  12. Fadel, Sezan R.; Bendif, Hamdi; Guedes, Laura; André, Rebeca; Pacheco, Rita; Guedes, Rita; Merabti, Karim; Miara, Mohamed Djamel; Serralheiro, Maria Luísa. "Bioactivities of iridoids and flavonoids present in decoctions from aerial parts of Verbascum betonicifolium". European Journal of Integrative Medicine 37 (2020): 101171. http://dx.doi.org/10.1016/j.eujim.2020.101171.
    Published • 10.1016/j.eujim.2020.101171
  13. André, Rebeca; Guedes, Laura; Melo, Ricardo; Ascensão, Lia; Pacheco, Rita; Vaz, Pedro D.; Serralheiro, Maria Luísa. "Effect of Food Preparations on In Vitro Bioactivities and Chemical Components of Fucus vesiculosus". Foods 9 7 (2020): 955. http://dx.doi.org/10.3390/foods9070955.
    10.3390/foods9070955
  14. Ressaissi, Asma; Attia, Nebil; Pacheco, Rita; Falé, Pedro Luis; Serralheiro, Maria Luísa M.. "Cholesterol transporter proteins in HepG2 cells can be modulated by phenolic compounds present in Opuntia ficus-indica aqueous solutions". Journal of Functional Foods 64 (2020): 103674. http://dx.doi.org/10.1016/j.jff.2019.103674.
    Published • 10.1016/j.jff.2019.103674
  15. Mejri, Faiza; Ben Khoud, Haifa; Njim, Leila; Baati, Tarek; Selmi, Slimen; Martins, Alice; Serralheiro, Maria L.M.; Rauter, Amelia P.; Hosni, Karim. "In vitro and in vivo biological properties of pea pods (Pisum sativum L.)". Food Bioscience 32 (2019): 100482. http://dx.doi.org/10.1016/j.fbio.2019.100482.
    10.1016/j.fbio.2019.100482
  16. Guedes, Laura; Reis, Pedro B. P. S.; Machuqueiro, Miguel; Ressaissi, Asma; Pacheco, Rita; Serralheiro, Maria Luísa. "Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies". Molecules 24 20 (2019): 3795. http://dx.doi.org/10.3390/molecules24203795.
    10.3390/molecules24203795
  17. André, Rebeca; Catarro, Joana; Freitas, Dalia; Pacheco, Rita; Oliveira, M. Conceição; Serralheiro, Maria Luísa; Falé, Pedro L.. "Action of euptox A from Ageratina adenophora juice on human cell lines: A top-down study using FTIR spectroscopy and protein profiling". Toxicology in Vitro 57 (2019): 217-225. http://dx.doi.org/10.1016/j.tiv.2019.03.012.
    Published • 10.1016/j.tiv.2019.03.012
  18. Zaidi, Hicham; Ouchemoukh, Salim; Amessis-Ouchemoukh, Nadia; Debbache, Nadjet; Pacheco, Rita; Serralheiro, M. Luisa; Araujo, M. Eduarda. "Biological properties of phenolic compound extracts in selected Algerian honeys—The inhibition of acetylcholinesterase and a-glucosidase activities". European Journal of Integrative Medicine 25 (2019): 77-84. http://dx.doi.org/10.1016/j.eujim.2018.11.008.
    Published • 10.1016/j.eujim.2018.11.008
  19. Henriques, Joana; Falé, Pedro Luis; Pacheco, Rita; Florêncio, Maria Helena; Serralheiro, Maria Luísa. "Phenolic compounds from Actinidia deliciosa leaves: Caco-2 permeability, enzyme inhibitory activity and cell protein profile studies". Journal of King Saud University - Science 30 4 (2018): 513-518. http://dx.doi.org/10.1016/j.jksus.2017.07.007.
    Published • 10.1016/j.jksus.2017.07.007
  20. Figueiredo, Neusa; Serralheiro, Maria; Canário, João; Duarte, Aida; Hintelmann, Holger; Carvalho, Cristina. "Evidence of Mercury Methylation and Demethylation by the Estuarine Microbial Communities Obtained in Stable Hg Isotope Studies". International Journal of Environmental Research and Public Health 15 10 (2018): 2141. http://dx.doi.org/10.3390/ijerph15102141.
    Published • 10.3390/ijerph15102141
  21. Brito, Elsa; Silva, André; Falé, Pedro Luis Vieira; Pacheco, Rita; Serralheiro, António; Haris, Parvez I.; Ascensão, Lia; Serralheiro, Maria Luísa. "Serum Albumin Modulates the Bioactivity of Rosmarinic Acid". Journal of Medicinal Food 21 8 (2018): 801-807. http://dx.doi.org/10.1089/jmf.2017.0086.
    Published • 10.1089/jmf.2017.0086
  22. Brito, Elsa; Gomes, Emma; Falé, Pedro L.; Borges, Carlos; Pacheco, Rita; Teixeira, Vitor; Machuqueiro, Miguel; Ascensão, Lia; Serralheiro, Maria Luisa M.. "Bioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxication". Journal of Ethnopharmacology 220 (2018): 147-154. http://dx.doi.org/10.1016/j.jep.2018.04.006.
    Published • 10.1016/j.jep.2018.04.006
  23. Mejri, Faiza; Selmi, Slimen; Martins, Alice; benkhoud, Haifa; Baati, Tarek; Chaabane, Hedia; Njim, Leila; et al. "Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties". Food & Function 9 4 (2018): 2051-2069. http://dx.doi.org/10.1039/c8fo00055g.
    Published • 10.1039/c8fo00055g
  24. Marques, P.; Marto, J.; Gonçalves, L.M.; Pacheco, R.; Fitas, M.; Pinto, P.; Serralheiro, M.L.M.; Ribeiro, H.. "Cynara scolymus L.: A promising Mediterranean extract for topical anti-aging prevention". Industrial Crops and Products 109 (2017): 699-706. http://dx.doi.org/10.1016/j.indcrop.2017.09.033.
    Published • 10.1016/j.indcrop.2017.09.033
  25. Gomes, Luís; Borges, Carlos; Serralheiro, M Luísa M; Minhalma, Miguel; Pacheco, Rita. "Cork processing wastewaters components fractioned by ultrafiltration membranes – studies of antioxidant and antitumoral activity". Journal of Chemical Technology & Biotechnology 93 3 (2017): 861-870. http://dx.doi.org/10.1002/jctb.5441.
    Published • 10.1002/jctb.5441
  26. Ressaissi, Asma; Attia, Nebil; Falé, Pedro Luis; Pacheco, Rita; Victor, Bruno L.; Machuqueiro, Miguel; Serralheiro, Maria Luísa M.. "Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies". Archives of Pharmacal Research 40 11 (2017): 1278-1286. http://dx.doi.org/10.1007/s12272-017-0959-1.
    Published • 10.1007/s12272-017-0959-1
  27. Figueiredo, Neusa L.; Canário, João; Serralheiro, Maria Luísa; Carvalho, Cristina. "Optimization of microbial detoxification for an aquatic mercury-contaminated environment". Journal of Toxicology and Environmental Health, Part A 80 13-15 (2017): 788-796. http://dx.doi.org/10.1080/15287394.2017.1357311.
    10.1080/15287394.2017.1357311
  28. Silva, Letícia; Rodrigues, Ana Margarida; Ciriani, Marina; Falé, Pedro Luis Vieira; Teixeira, Vitor; Madeira, Paulo; Machuqueiro, Miguel; et al. "Antiacetylcholinesterase activity and docking studies with chlorogenic acid, cynarin and arzanol from Helichrysum stoechas (Lamiaceae)". Medicinal Chemistry Research 26 11 (2017): 2942-2950. http://dx.doi.org/10.1007/s00044-017-1994-7.
    Published • 10.1007/s00044-017-1994-7
  29. Batista, Daniela; Falé, Pedro L.; Serralheiro, Maria L.; Araújo, Maria-Eduarda; Dias, Catarina; Branco, Isabel; Grosso, Clara; et al. "Phytochemical Characterization and Biological Evaluation of the Aqueous and Supercritical Fluid Extracts from Salvia sclareoides Brot". Open Chemistry 15 1 (2017): 82-91. http://dx.doi.org/10.1515/chem-2017-0011.
    10.1515/chem-2017-0011
  30. Henriques, Joana; Ribeiro, Maria João; Falé, Pedro L.; Pacheco, Rita; Ascensão, Lia; Florêncio, Maria Helena; Serralheiro, M. L. M.. "Valorization of kiwifruit production: leaves of the pruning branches of Actinidia deliciosa as a promising source of polyphenols". European Food Research and Technology 243 8 (2017): 1343-1353. http://dx.doi.org/10.1007/s00217-017-2845-y.
    10.1007/s00217-017-2845-y
  31. Arantes, Ana A.; Falé, Pedro L.; Costa, Larissa C.B.; Pacheco, Rita; Ascensão, Lia; Serralheiro, Maria Luísa. "Inhibition of HMG-CoA reductase activity and cholesterol permeation through Caco-2 cells by caffeoylquinic acids from Vernonia condensata leaves". Revista Brasileira de Farmacognosia 26 6 (2016): 738-743. http://dx.doi.org/10.1016/j.bjp.2016.05.008.
    Published • 10.1016/j.bjp.2016.05.008
  32. Khadhri, Ayda; Bouali, Intidhar; Belkhir, Samia; Mokded, Rabhi; Smiti, Samira; Falé, Pedro; Araújo, Maria Eduarda M.; Serralheiro, Maria Luisa M.. "In vitro digestion, antioxidant and antiacetylcholinesterase activities of two species of Ruta: Ruta chalepensis and Ruta montana". Pharmaceutical Biology 55 1 (2016): 101-107. http://dx.doi.org/10.1080/13880209.2016.1230634.
    10.1080/13880209.2016.1230634
  33. Mendes, A.R.; Lopo, S.; Ascensão, L.; Fale, P.L.; Serralheiro, M.L.; Caeiro, M.F.; Serralheiro, Maria. "Evaluation of the antiviral activity of an aqueous extract from Solidago virgaurea against Herpes simplex virus type 2". Journal of Clinical Virology 82 (2016): S133. http://dx.doi.org/10.1016/j.jcv.2016.08.267.
    10.1016/j.jcv.2016.08.267
  34. Marques, Ana Patrícia; Serralheiro, Maria Luisa; Ferreira, António E.N.; Freire, Ana Ponces; Cordeiro, Carlos; Silva, Marta Sousa. "Metabolomics for undergraduates: Identification and pathway assignment of mitochondrial metabolites". Biochemistry and Molecular Biology Education 44 1 (2015): 38-54. http://dx.doi.org/10.1002/bmb.20919.
    Published • 10.1002/bmb.20919
  35. Batista, Daniela; Falé, Pedro L.; Serralheiro, Maria L.; Araújo, Maria E.; Madeira, Paulo J. A.; Borges, Carlos; Torgal, Isabel; et al. "New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract". Natural Products and Bioprospecting 5 6 (2015): 277-285. http://dx.doi.org/10.1007/s13659-015-0077-z.
    Published • 10.1007/s13659-015-0077-z
  36. Figueiredo, N.; Hintelmann, H.; Canário, J.; Serralheiro, L.; Carvalho, C.. "Evaluation of mercury methylation/demethylation by the microbial community of Tagus estuary using stable Hg isotopes". Toxicology Letters 238 2 (2015): S135. http://dx.doi.org/10.1016/j.toxlet.2015.08.424.
    Published • 10.1016/j.toxlet.2015.08.424
  37. Barra, M.; Barbosa, N; Resende, F.; Alves de Matos, A.P.; Falé, P.L.; Ascensão, L.; Serralheiro, M.L.M.; Caeiro, M.F.. "Antiviral and virucidal effects of plant aqueous extracts against Herpes simplex and Encephalomyocarditis murine viruses". Microscopy and Microanalysis 21 S6 (2015): 42-43. http://dx.doi.org/10.1017/s1431927614013889.
    Published • 10.1017/s1431927614013889
  38. Quintanova, Catarina; Keri, Rangappa S.; Marques, Sérgio M.; G-Fernandes, Maria; Cardoso, Sandra M.; Luísa Serralheiro, M.; Amélia Santos, M.. "Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs". MedChemComm 6 11 (2015): 1969-1977. http://dx.doi.org/10.1039/c5md00236b.
    Published • 10.1039/c5md00236b
  39. Rijo, Patrícia; Falé, Pedro L.; Serralheiro, M.L.; Simões, M.F.; Gomes, Ana; Reis, Catarina. "Optimization of medicinal plant extraction methods and their encapsulation through extrusion technology". Measurement 58 (2014): 249-255. http://dx.doi.org/10.1016/j.measurement.2014.08.045.
    Published • 10.1016/j.measurement.2014.08.045
  40. Amessis-Ouchemoukh, Nadia; Madani, Khodir; Falé, Pedro L.V.; Serralheiro, M. Luisa; Araújo, Maria Eduarda M.. "Antioxidant capacity and phenolic contents of some Mediterranean medicinal plants and their potential role in the inhibition of cyclooxygenase-1 and acetylcholinesterase activities". Industrial Crops and Products 53 (2014): 6-15. http://dx.doi.org/10.1016/j.indcrop.2013.12.008.
    10.1016/j.indcrop.2013.12.008
  41. Figueiredo, Neusa L. L.; Canário, João; Duarte, Aida; Serralheiro, Maria Luísa; Carvalho, Cristina. "Isolation and Characterization of Mercury-Resistant Bacteria From Sediments of Tagus Estuary (Portugal): Implications for Environmental and Human Health Risk Assessment". Journal of Toxicology and Environmental Health, Part A 77 1-3 (2014): 155-168. http://dx.doi.org/10.1080/15287394.2014.867204.
    Published • 10.1080/15287394.2014.867204
  42. Figueiredo, Neusa. "Phytochemical Analysis of Plectranthus sp. Extracts and Application in Inhibition of Dental Bacteria, Streptococcus sobrinus and Streptococcus mutans". European Journal of Medicinal Plants 4 7 (2014): 794-809. http://dx.doi.org/10.9734/ejmp/2014/7544.
    Published • 10.9734/ejmp/2014/7544
  43. Pedro, L. Fal; Catarina, Ferreira; Ana, M. Rodrigues; Ftima, N. Frazo; Maria, L. M. Serralheiro. "Studies on the molecular mechanism of cholesterol reduction by Fraxinus angustifolia, Peumus boldus, Cynara cardunculus and Pterospartum tridentatum infusions". Journal of Medicinal Plants Research 8 1 (2014): 9-17. http://dx.doi.org/10.5897/jmpr2013.5273.
    Published • 10.5897/jmpr2013.5273
  44. Falé, Pedro L.; Ferreira, Catarina; Maruzzella, Federica; Helena Florêncio, Maria; Frazão, Fátima N.; Serralheiro, Maria L.M.. "Evaluation of cholesterol absorption and biosynthesis by decoctions of Annona cherimola leaves". Journal of Ethnopharmacology 150 2 (2013): 718-723. http://dx.doi.org/10.1016/j.jep.2013.09.029.
    Published • 10.1016/j.jep.2013.09.029
  45. Bernardo, Marisa; Pacheco, Rita; Serralheiro, Maria Luísa M.; Karmali, Amin. "Production of hydroxamic acids by immobilized Pseudomonas aeruginosa cells: Kinetic analysis in reverse micelles". Journal of Molecular Catalysis B: Enzymatic 93 (2013): 28-33. http://dx.doi.org/10.1016/j.molcatb.2013.03.016.
    Published • 10.1016/j.molcatb.2013.03.016
  46. Serralheiro, Maria L. M.; Falé, Pedro L.; Ferreira, Catarina; Rodrigues, Ana M.; Cleto, Pedro; Madeira, Paulo J. Amorim; Florêncio, Maria H.; Frazão, Fátima N.. "Antioxidant and anti-acetylcholinesterase activity of commercially available medicinal infusions after in vitro gastrointestinal digestion". Journal of Medicinal Plants Research 7 20 (2013): 1370-1378. http://dx.doi.org/10.5897/jmpr13.4438.
    Published • 10.5897/jmpr13.4438
  47. Dinis, Pedro. "Acetylcholinesterase Inhibitory Activity After in vitro Gastrointestinal Digestion of Infusions of Mentha Species". European Journal of Medicinal Plants 3 3 (2013): 381-393. http://dx.doi.org/10.9734/ejmp/2013/3430.
    Published • 10.9734/ejmp/2013/3430
  48. Falé, Pedro L.; Ascensão, Lia; Serralheiro, Maria L. M.. "Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers". Food Funct. 4 3 (2013): 426-431. http://dx.doi.org/10.1039/c2fo30318c.
    Published • 10.1039/c2fo30318c
  49. Falé, P.L.; Amaral, F.; Amorim Madeira, P.J.; Sousa Silva, M.; Florêncio, M.H.; Frazão, F.N.; Serralheiro, M.L.M.. "Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines". Food and Chemical Toxicology 50 8 (2012): 2656-2662. http://dx.doi.org/10.1016/j.fct.2012.04.049.
    Published • 10.1016/j.fct.2012.04.049
  50. Falé, Pedro L. V.; Ascensão, Lia; Serralheiro, M. Luisa; Haris, Parvez I.. "Interaction between Plectranthus barbatus herbal tea components and acetylcholinesterase: binding and activity studies". Food & Function 3 11 (2012): 1176. http://dx.doi.org/10.1039/c2fo30032j.
    Published • 10.1039/c2fo30032j
  51. Roseiro, Luísa Bivar; Rauter, Amélia Pilar; Serralheiro, Maria Luísa Mourato. "Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease". Nutrition and Aging 1 2 (2012): 99-111. http://dx.doi.org/10.3233/nua-2012-0006.
    Published • 10.3233/nua-2012-0006
  52. Gil, Dulce M.A.; Falé, Pedro L.V.; Serralheiro, Maria L.M.; Rebelo, Maria J.F.. "Herbal infusions bioelectrochemical polyphenolic index: Green tea – The gallic acid interference". Food Chemistry 129 4 (2011): 1537-1543. http://dx.doi.org/10.1016/j.foodchem.2011.06.003.
    Published • 10.1016/j.foodchem.2011.06.003
  53. Proença, Carla; Serralheiro, M. Luísa; Araújo, M. Eduarda; Pamplona, Teresa; Santos, Susana; Santos, M. Soledade; Frazão, Fátima. "Novel sulfenamides as promising acetylcholinesterase inhibitors". Journal of Heterocyclic Chemistry 48 6 (2011): 1287-1294. http://dx.doi.org/10.1002/jhet.752.
    Published • 10.1002/jhet.752
  54. Figueiredo, N.; Serralheiro, M.L.; Lino, A.R.; Carvalho, C.. "Biochemical characterization of sulphate reducing bacteria isolated from Tagus Estuary (Lisbon, Portugal) exhibiting resistance to mercury compounds to evaluate their contribution to mercury cycle". Toxicology Letters 205 (2011): S121. http://dx.doi.org/10.1016/j.toxlet.2011.05.435.
    Published • 10.1016/j.toxlet.2011.05.435
  55. Serralheiro, Maria. "Interaction Between Plectranthus Barbatus Herbal Tea Components and Human Serum Albumin and Lysozyme: Binding and Activity Studies". Spectrosc. – Int. J., 26 (2011): 79-92.
    Published
  56. Falé, Pedro L. V.; Madeira, Paulo J. Amorim; Florêncio, M. Helena; Ascensão, Lia; Serralheiro, Maria Luísa M.. "Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitor". Food Funct. 2 2 (2011): 130-136. http://dx.doi.org/10.1039/c0fo00070a.
    Published • 10.1039/c0fo00070a
  57. Šebestík, Jaroslav; Marques, Sérgio M.; Falé, Pedro L.; Santos, Susana; Arduíno, Daniela M.; Cardoso, Sandra M.; Oliveira, Catarina R.; Serralheiro, M. Luísa M.; Santos, M. Amélia. "Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors". Journal of Enzyme Inhibition and Medicinal Chemistry 26 4 (2010): 485-497. http://dx.doi.org/10.3109/14756366.2010.529806.
    Published • 10.3109/14756366.2010.529806
  58. Cruz, Diana; Falé, Pedro L.; Mourato, Ana; Vaz, Pedro D.; Luisa Serralheiro, M.; Lino, Ana Rosa L.. "Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena)". Colloids and Surfaces B: Biointerfaces 81 1 (2010): 67-73. http://dx.doi.org/10.1016/j.colsurfb.2010.06.025.
    Published • 10.1016/j.colsurfb.2010.06.025
  59. Ramos, Margarida; Salústio, Paulo; Serralheiro, Luísa; Fazão, Fátima; Marques, Helena. "Stability and enzymatic studies with omeprazole:hydroxypropyl-ß-cyclodextrin". Journal of Inclusion Phenomena and Macrocyclic Chemistry 70 3-4 (2010): 407-414. http://dx.doi.org/10.1007/s10847-010-9884-3.
    Published • 10.1007/s10847-010-9884-3
  60. Porfírio, Sara; Falé, Pedro L.V.; Madeira, Paulo J. Amorim; Florêncio, M. Helena; Ascensão, Lia; Serralheiro, Maria Luísa M.. "Antiacetylcholinesterase and antioxidant activities of Plectranthus barbatus tea, after in vitro gastrointestinal metabolism". Food Chemistry 122 1 (2010): 179-187. http://dx.doi.org/10.1016/j.foodchem.2010.02.044.
    Published • 10.1016/j.foodchem.2010.02.044
  61. Hernandez, Maria Filipa; Falé, Pedro L.V.; Araújo, Maria Eduarda M.; Serralheiro, Maria Luísa M.. "Acetylcholinesterase inhibition and antioxidant activity of the water extracts of several Hypericum species". Food Chemistry 120 4 (2010): 1076-1082. http://dx.doi.org/10.1016/j.foodchem.2009.11.055.
    Published • 10.1016/j.foodchem.2009.11.055
  62. Figueiredo, Neusa L.; de Aguiar, Sara Raquel M.M.; Falé, Pedro Luis; Ascensão, Lia; Serralheiro, Maria Luisa M.; Lino, Ana Rosa L.. "The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans". Food Chemistry 119 2 (2010): 664-668. http://dx.doi.org/10.1016/j.foodchem.2009.07.008.
    Published • 10.1016/j.foodchem.2009.07.008
  63. Khadri, Ayda; Neffati, Mohamed; Smiti, Samira; Falé, Pedro; Lino, A. Rosa L.; Serralheiro, M. Luisa M.; Araújo, M. Eduarda M.. "Antioxidant, antiacetylcholinesterase and antimicrobial activities of Cymbopogon schoenanthus L. Spreng (lemon grass) from Tunisia". LWT - Food Science and Technology 43 2 (2010): 331-336. http://dx.doi.org/10.1016/j.lwt.2009.08.004.
    Published • 10.1016/j.lwt.2009.08.004
  64. Falé, Pedro L.; Borges, Carlos; Madeira, Paulo J. Amorim; Ascensão, Lia; Araújo, Maria Eduarda M.; Florêncio, Maria Helena; Serralheiro, Maria Luísa M.. "Rosmarinic acid, scutellarein 4'-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (“falso boldo”)". Food Chemistry 114 3 (2009): 798-805. http://dx.doi.org/10.1016/j.foodchem.2008.10.015.
    Published • 10.1016/j.foodchem.2008.10.015
  65. Rauter, Amélia P.; Martins, Alice; Lopes, Rui; Ferreira, Joana; Serralheiro, Luísa M.; Araújo, Maria-Eduarda; Borges, Carlos; et al. "Bioactivity studies and chemical profile of the antidiabetic plant Genista tenera". Journal of Ethnopharmacology 122 2 (2009): 384-393. http://dx.doi.org/10.1016/j.jep.2008.10.011.
    Published • 10.1016/j.jep.2008.10.011
  66. Pacheco, Rita; Karmali, Amin; Serralheiro, M Luisa; Haris, Parvez. "Substrate interaction with recombinant amidase from Pseudomonas aeruginosa during biocatalysis". Biocatalysis and Biotransformation (2009): 1-10. http://dx.doi.org/10.1080/10242420903287701.
    Published • 10.1080/10242420903287701
  67. Khadri, Ayda; Serralheiro, M.L.M.; Nogueira, J.M.F.; Neffati, Mohamed; Smiti, Samira; Araújo, M.E.M.. "Antioxidant and antiacetylcholinesterase activities of essential oils from Cymbopogon schoenanthus L. Spreng. Determination of chemical composition by GC–mass spectrometry and 13C NMR". Food Chemistry 109 3 (2008): 630-637. http://dx.doi.org/10.1016/j.foodchem.2007.12.070.
    Published • 10.1016/j.foodchem.2007.12.070
  68. Falé, PLV; Araújo, MEM; Ascensão, L; Serralheiro, MLM. "Acetylcholinesterase inhibition by Rosmarinic acid from Plectranthus (Lamiaceae) species". Planta Medica 74 09 (2008): http://dx.doi.org/10.1055/s-0028-1084086.
    Published • 10.1055/s-0028-1084086
  69. Mata, A.T.; Proença, C.; Ferreira, A.R.; Serralheiro, M.L.M.; Nogueira, J.M.F.; Araújo, M.E.M.. "Antioxidant and antiacetylcholinesterase activities of five plants used as Portuguese food spices". Food Chemistry 103 3 (2007): 778-786. http://dx.doi.org/10.1016/j.foodchem.2006.09.017.
    Published • 10.1016/j.foodchem.2006.09.017
  70. Ferreira, A.; Proença, C.; Serralheiro, M.L.M.; Araújo, M.E.M.. "The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal". Journal of Ethnopharmacology 108 1 (2006): 31-37. http://dx.doi.org/10.1016/j.jep.2006.04.010.
    Published • 10.1016/j.jep.2006.04.010
  71. Martins, S.; Karmali, A.; Serralheiro, M.L.. "Kinetic properties of wild-type and altered recombinant amidases by the use of ion-selective electrode assay method". Analytical Biochemistry 355 2 (2006): 232-239. http://dx.doi.org/10.1016/j.ab.2006.04.023.
    Published • 10.1016/j.ab.2006.04.023
  72. Martins, Sónia; Karmali, Amin; Andrade, Jorge; Serralheiro, Maria Luísa. "Immobilized Metal Affinity Chromatography of Monoclonal Immunoglobulin M Against Mutant Amidase From Pseudomonas aeruginosa". Molecular Biotechnology 33 2 (2006): 103-114. http://dx.doi.org/10.1385/mb:33:2:103.
    Published • 10.1385/mb:33:2:103
  73. Martins, Sónia; Andrade, Jorge; Karmali, Amin; Serralheiro, Maria Luísa. "Screening of suitable immobilized metal chelates for adsorption of monoclonal antibodies against mutant amidase fromPseudomonas aeruginosa". Journal of Molecular Recognition 19 4 (2006): 340-347. http://dx.doi.org/10.1002/jmr.773.
    Published • 10.1002/jmr.773
  74. Pacheco, R.; Karmali, A.; Serralheiro, M.L.M.; Haris, P.I.. "Application of Fourier transform infrared spectroscopy for monitoring hydrolysis and synthesis reactions catalyzed by a recombinant amidase". Analytical Biochemistry 346 1 (2005): 49-58. http://dx.doi.org/10.1016/j.ab.2005.07.027.
    Published • 10.1016/j.ab.2005.07.027
  75. Albuquerque, M.G.E.; Lopes, A.T.; Serralheiro, M.L.; Novais, J.M.; Pinheiro, H.M.. "Biological sulphate reduction and redox mediator effects on azo dye decolourisation in anaerobic–aerobic sequencing batch reactors". Enzyme and Microbial Technology 36 5-6 (2005): 790-799. http://dx.doi.org/10.1016/j.enzmictec.2005.01.005.
    Published • 10.1016/j.enzmictec.2005.01.005
  76. Pacheco, Rita; Karmali, Amin; Matos-Lopes, Manuel L.; Serralheiro, Maria-Luisa. "Amidase encapsulated in TTAB reversed micelles for the study of transamidation reactions". Biocatalysis and Biotransformation 23 6 (2005): 407-414. http://dx.doi.org/10.1080/10242420500372419.
    Published • 10.1080/10242420500372419
  77. Martins, Sónia; Karmali, Amin; Andrade, Jorge; Custódio, Ana; Serralheiro, Maria Luísa. "Characterization of Monoclonal Antibodies Against Altered (T103I) Amidase From Pseudomonas aeruginosa". Molecular Biotechnology 30 3 (2005): 207-220. http://dx.doi.org/10.1385/mb:30:3:207.
    Published • 10.1385/mb:30:3:207
  78. Pacheco, R; Serralheiro, M.L.M; Karmali, A; Haris, P.I. "Measuring enzymatic activity of a recombinant amidase using Fourier transform infrared spectroscopy". Analytical Biochemistry 322 2 (2003): 208-214. http://dx.doi.org/10.1016/j.ab.2003.07.012.
    Published • 10.1016/j.ab.2003.07.012
  79. Serralheiro, Maria. "Development of a New Amperometric Biosensor for Lactose Determination". Portugaliae Electrochimica Acta 21 (2003): 171-177.
    Published
  80. Pedro, A.J.E.; Fevereiro, P.S.; Serralheiro, M.L.; Aires-Barros, M.R.. "Study of the Stability Of Vaccinium myrtillus Peroxidase in Reverse Micellar Systems". Biocatalysis and Biotransformation 20 2 (2002): 129-135. http://dx.doi.org/10.1080/10242420290018113.
    Published • 10.1080/10242420290018113
  81. Serralheiro, Maria. "Teaching of Biotechnology in the Biochemistry Course". Electronic Journal of Biotechnology 5 15 (2002): 212-215.
    Published
  82. Serralheiro, Maria. "Anaerobic Reduction of a Sulfonated Azo Dye, Congo Red, by Sulfate Reducing Bacteria". Appl. Biochem. Biotech 97 (2002): 147-163.
    Published
  83. Serralheiro, Maria. "Development of a new Amperometric Biosensor Based on Plyphenoloxidase and Polyethersulphone Membrane". Pure Appl. Chem 73 11 (2001): 1-7.
    Published
  84. Serralheiro, M.L.M; Cabral, J.M.S. "Irreversible thermoinactivation of a-chymotrypsin in buffer and water miscible organic solvent. Comparison with a reverse micellar system". Journal of Molecular Catalysis B: Enzymatic 7 1-4 (1999): 191-205. http://dx.doi.org/10.1016/s1381-1177(99)00029-6.
    Published • 10.1016/s1381-1177(99)00029-6
  85. Serralheiro, M.L.M; Prazeres and, D.M.F; Cabral, J.M.S. "Continuous production and simultaneous precipitation of a dipeptide in a reversed micellar membrane reactor". Enzyme and Microbial Technology 24 8-9 (1999): 507-513. http://dx.doi.org/10.1016/s0141-0229(98)00141-0.
    Published • 10.1016/s0141-0229(98)00141-0
  86. Serralheiro, M. L. M.; Cabral, J. M. S.. "Thermal Stability of a-Chymotrypsin, Native and Chemically Modified, Inside Reverse Micelles During Peptide Synthesis". Biocatalysis and Biotransformation 17 1 (1999): 3-19. http://dx.doi.org/10.3109/10242429909003203.
    Published • 10.3109/10242429909003203
  87. Morna-Gomes, Ana; Serralheiro, Maria Luisa; Fevereiro, Pedro Salema; Aires-Barros, Maria Raquel. "Application of Factorial Design to the Optimization of Peroxidase Activity in Reverse Micelles of bis(2-ethylhexyl)Sodium Sulfosuccinate/ Isooctane". Applied Biochemistry and Biotechnology 82 1 (1999): 27-36. http://dx.doi.org/10.1385/abab:82:1:27.
    Published • 10.1385/abab:82:1:27
  88. Carvalho, C.M.L.; Serralheiro, M.L.M.; Cabral, J.M.S.; Aires-Barros, M.R.. "Application of factorial design to the study of transesterification reactions using cutinase in AOT-reversed micelles". Enzyme and Microbial Technology 21 2 (1997): 117-123. http://dx.doi.org/10.1016/s0141-0229(96)00245-1.
    Published • 10.1016/s0141-0229(96)00245-1
  89. Serralheiro, M.L.M.; Prazeres, D.M.F.; Cabral, J.M.S.. "Dipeptide synthesis and separation in a reversed micellar membrane reactor". Enzyme and Microbial Technology 16 12 (1994): 1064-1073. http://dx.doi.org/10.1016/0141-0229(94)90144-9.
    Published • 10.1016/0141-0229(94)90144-9
  90. Serralheiro, M. L. M.; Cabral, J. M. S.. "Synthesis of AcPheLeuNH2 by ?-chymotrypsin in TTAB reversed micelles: Application of response surface methodology to the optimization of the system". Biotechnology and Bioengineering 43 11 (1994): 1031-1042. http://dx.doi.org/10.1002/bit.260431106.
    Published • 10.1002/bit.260431106
  91. Calvet, S.; Clapés, P.; Vigo, J. P.; Xaus, N.; Jorba, X.; Mas, R. M.; Torres, J. L.; et al. "Application of empirical design methodologies to the study of the influence of reaction conditions andN-a-protecting group structure on the enzymatic X-Phe-Leu-NH2dipeptide synthesis in buffer/dimethylformamide solvents systems". Biotechnology and Bioengineering 39 5 (1992): 539-549. http://dx.doi.org/10.1002/bit.260390509.
    Published • 10.1002/bit.260390509
  92. Serralheiro, Maria. "Thermostability of ¿-Chymotrypsin in Water / Organic Solvent Systems". Biotechnol. Lett 14 11 (1992): 1041-1044.
    Published
  93. SERRALHEIRO, M. L.; EMPIS, J. M.; CABRAL, J. M. S.. "Peptide Synthesis by Microencapsulated Chymotrypsin". Annals of the New York Academy of Sciences 613 1 Enzyme E (1990): 638-642. http://dx.doi.org/10.1111/j.1749-6632.1990.tb18236.x.
    Published • 10.1111/j.1749-6632.1990.tb18236.x
  94. Serralheiro, Maria. "Thermostability of ¿-Chymotrypsin Encapsulated in Reversed Micelles". Biotechnol. Lett., 12 3 (1990): 167-172.
    Published
  95. Karmali, Amin; Serralheiro, Luisa. "Improved purification and properties of glucose dehydrogenase fromBacillus subtilis". Biochimie 70 10 (1988): 1401-1409. http://dx.doi.org/10.1016/0300-9084(88)90012-0.
    Published • 10.1016/0300-9084(88)90012-0
  96. Serralheiro, Maria. "TLC Confirmation of Aflatoxin M1 Extracted from Milk". J. Assoc. Off. Anal. Chem 69 5 (1986): 886-888.
    Published
  97. Serralheiro, Maria. "Rapid Thin Layer Chromatographic Determination of Aflatoxin M1 in Powdered Milk". J. Assoc. Off. Anal. Chem 68 5 (1985): 952-954.
    Published
Working paper
  1. Serralheiro, Maria. 1984. "Moniliformina, uma Micotoxina de Várias Espécies de Fusarium".
  2. Serralheiro, Maria. 1984. "Método para Pesquisa de Várias Micotoxinas na Pimenta; uma Primeira Tentativa".
  3. Serralheiro, Maria. 1981. "CBO - Estudo Bibliográfico".
  4. Serralheiro, Maria. 1981. "Documentação Bibliográfica sobre Carência Bioquímica de Oxigénio existente na Unidade de Métodos Biológicos".

Intellectual property

Patent
  1. Serralheiro, Maria. 2013. "Extracto de bagaço de azeitona inibidor da enzima acetilcolinesterase". Portugal.
  2. Serralheiro, Maria. 2002. "Processo para produção contínua de cristais dipéptidos num reactor de hidrociclone e membrana via síntese enzimática e cristalização simultânea em sistemas de micelas invertidas". Portugal.
    Expired
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2022 Impact of phenolic compounds from C. cardunculus on the synthesis and bioactivity of cheese Pseudomonas pigment
Supervisor
 Bioquímica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2022 Molecules for Health: cholesterol absorption and transporter proteins expression under the effect of bioactive molecules
Supervisor
 Biologia (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2021 Bioprospection, study and application of bioactive compounds from microalgae and seaweed.
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Influencia de infusões de folhas de goiabeira na permeação do colesterol através da barreira intestinal: acção sobre os sistemas transportadores de membrana e sobre outras biomoleculas. Mestrado em Bioquimica. (co-orientação).
Co-supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2020 Antioxidant properties and enzymatic activity towards acetylcholinesterase in the macroalgae Fucus vesiculosus and its variation with sex, growth stage and seasonality
Co-supervisor
 Biologia dos Recursos Vegetais (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019 Atividade anti-hipercolesterolémica de algas da costa portuguesa
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2018 Estudos de Bioatividade de Decocções de Centaurium erythraea
Supervisor
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2018 Bioactivity of Opuntian ficus indica: antiacetycholinesterase and hypocholesterolemia activity
Co-supervisor
 Bioquíma (PhD)
Université de Carthage Faculté des Sciences de Bizerte, Tunisia
2012 - 2016 Microbial Community Composition and Mercury Cycling in Sediments of Tagus Estuary
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Influencia de compostos fenólicos presentes em infusões na absorção de aminoácidos por linhas celulares, Caco-2 e HepG2
Supervisor
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Estudo da acção de misturas de plantas comerciais na bioquímica de linhas celulares
Co-supervisor
 Mestrado Integrado Bioengenharia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2014 Infusão de Vernonia condensata: composição química e relação com actividades biológicas medicinais
Supervisor
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Mecanismo molecular de acção das infusões no transporte de colesterol através da membrana celular
Supervisor
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Novos compostos híbridos com potencial ação neuroprotectora
Co-supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2012 Actividades inibitórias de colinesterases e antioxidante de extractos de plantas utilizadas como chás
Co-supervisor
 Ciências Farmacêuticas (Master)
Universidade Lusófona de Angola, Angola
2011 - 2012 Estudo da actividade antimicrobiana e activação biológica de ésteres de ácidos orgânicos fracos»
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2012 Acção de extractos aquosos de espécies de Plectranthus sobre a actividade de acetilcolinesterase. Estudos in vivo de actividade, biodisponibilidade e metabolismo
Co-supervisor
 Bioquímica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Desenvolvimento de métodos para estudo de inibidores de acetilcolinesterase
Co-supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Efeito de extractos aquosos de Plectranthus barbatus e de Peumus boldus na acção do etanol e na absorção conjunta de colesterol em linhas celulares
Supervisor
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2001 - 2005 Wild-type and recombinant mutant amidases from Pseudomonas aeruginosa: structural and kinetic characterization by using monoclonal antibodies
Co-supervisor
 Bioquímica (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2001 - 2005 Recombinant wild-type amidase from Pseudomonas aeruginosa purification for the synthesis in different media. Structure-function relationship
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Estudo de fatores associados à produção de pigmentos de origem microbiana em queijos laborados com leite cru
(Thesis) Arguer
 Inês Sofia Silvestre Lourenço (Master)
Instituto Politécnico de Castelo Branco Escola Superior Agrária, Portugal
2020 Estudos de esteres de derivados do acido benzoico com álcoois de cadeia longa como pro-fármacos destinado ao tratamento da tuberculose
(Thesis) Arguer
 Raquel Maria Simões Freire (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 Targeting colorectal cancer cell proliferation by bioactive triterpenic compounds derived from olive oil tree and reapeberries using 3D cell model approach
(Thesis) Arguer
 João Gonçalo D. Santana (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 Biosensor Evaluation of the Antioxidant Activity of Wines and Teas. Interferences strudies and comparison with other methods”. Grau de Doutor em Bioquímica
(Thesis) Arguer
 Dulce Martins Albuquerque Gil (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 A Novel Tool to Improve Protein Stability: Synthesis and Screening of Triazine-scaffolded Affinity Ligands to Bind and Stabilise Cutinase
(Thesis) Arguer
 Isabel Teixeira de Sousa (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 Enzymatic Transesterification of Triglycerides by Cutinase for Biodiesel Production
(Thesis) Arguer
 Sara Martins Badenes (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 Aromatic Ester Synthesis using Cutinase: A Case Study of an Integrated Biocatalyst Design
(Thesis) Arguer
 Dragan Popovic Correia de Barros (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Committee member

Activity description
Role 		Institution / Organization
2009 - 2023 ERASMUS em Bioquímica
Coordinator
 Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2016 Coordenação do Centro de Quimica e Bioquímica
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2009 Comissão executiva do Departamento de Química e Bioquímica
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - Current Bioquimica da Nutrição Biquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
1997 - Current Introdução à Biotecnologia Bioquimica (Licenciatura) Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2003 - 2019 Bioquímica Experimental I Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2018 Bioquímica Experimental II Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2017 Bromatologia Quimica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2015 Biotecnologia Molecular Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
1996 - 2014 Bioquímcia I Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2011 Projecto Empresarial Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
1988 - 2003 Métodos Instrumentais de Análise Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
1999 - 2001 Biocatálise Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
1989 - 1995 Bioquímica II Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers Frontiers Media SA
2019 - Current Molecules MDPI

Other jury / evaluation

Activity description Institution / Organization
2017 - 2019 Avaliação de propostas de projecto no programa COST da UE
2006 - 2009 Projectos da Agencia de Inovação
Distinctions

Other distinction

2014 Food and Nutrition Award (2ª Menção Honrosa)
2013 Key Scientific Article
2011 BEST PAPER AWARD
2011 TOP TEN ACCESSED ARTICLES
2011 BEST PAPER AWARD
Universidade de Lisboa Centro de Química e Bioquímica, Portugal