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Sara Francisca Ramalhosa Guerreiro is a PhD student in Health Sciences at ICVS, Medical School, University of Minho. She obtained her BSc in Biochemistry at Sciences School, University of Minho in 2016 and her MSc in Health Sciences in the Medical School, University of Minho in 2018. She started her career working on clarifying the role Tau protein in several conditions, such as chronic pain, Alzheimer's disease and stress-induced pathology. To accomplish that, she worked with several mice models lacking (TauKO) and overexpressing (P301L) Tau protein. Next, she focused in the study of movement disorders, more specifically, Machado Joseph disease (MJD), and its possible therapeutic targets through the testing of several therapeutic strategies (NLX-112, citalopram, intermittent fasting) in mice mimicking the disease. Currently, she is focused in comprehending the molecular pathways underlying neurodevelopmental disorders, specifically Down syndrome. Overall, she obtained training in working with mice, such as motor, anxiogenic, cognitive, depressive and drug-preference animal behavior, surgeries, blood collection, intraperitoneal injections and euthanizing. Besides, she also has experience in tissue processing and molecular cellular techniques, such as vibratome and criostate brain and spinal cord slicing, subcellular nuclear fractionation, western blotting, DNA and mRNA extraction, PCR and RT-qPCR analysis, immunofluorescence and immunohistochemistry. Additionally, she has experience in manual neuronal reconstruction using the Golgi-cox technique and, to complement, in 2017, she received training in the University of Osnabrueck, Germany, in confocal microscopy and semi-automated neuronal reconstruction as well as in working with cellular primary cultures. In the future, she wants to better understand the mechanisms underlying the development and progression of genetic disorders since it allows the selection of more adequate therapeutic targets and, consequently, the development of better compounds. She received 2 travel award for the international workshop organized by European College Neuropsychopharmacology (ENCP), Nice 2018 and for the International Society for Neurochemistry (ISN) and the Asian Pacific Society of Neurochemistry (APSN), Honolulu 2022 and 1 oral presentation, in the AD/PD meeting as well as she presented her work in several national and international congresses, and published 1 abstract and has 1 paper as first author and 1 paper as co-author.
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Identification

Personal identification

Full name
Sara Francisca Ramalhosa Guerreiro

Citation names

  • Guerreiro, Sara R.
  • Guerreiro, S.

Author identifiers

Ciência ID
1619-7A68-CDF3
ORCID iD
0000-0001-7521-5119

Email addresses

  • sarafranciscarguerreiro@hotmail.com (Professional)
  • b12098@alunos.uminho.pt (Professional)

Telephones

Mobile phone
  • 253604835 (Professional)

Addresses

  • Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Proficiency (C2) Upper intermediate (B2) Proficiency (C2)
Education
Degree Classification
2023/01 - 2027
Ongoing
 Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2023/03/06 - 2023/03/31
Concluded
 Finding solutions in a dish: advanced human in vitro modeling approaches for fundamental and translational research (Outros)
Universidade do Minho, Portugal
2023/01/30 - 2023/02/17
Concluded
 Bioinformatics in Health Sciences (Outros)
Universidade do Minho, Portugal
2021/07/25 - 2021/09/15
Concluded
 Online course: "Writing in the Sciences" (Outros)
Stanford University, United States
 95.84%
2016/09 - 2018/06
Concluded
 Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Clarifying the role of Tau protein in the mechanisms of brain damage induced by peripheral neuropathy" (THESIS/DISSERTATION)
 17
2017/04/26 - 2017/05/12
Concluded
 Advanced course: "Hands On: Rodent brain (1st Edition)" (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01/30 - 2017/02/10
Concluded
 Advanced course: Laboratory Animal Science (12th Edition) Based on FELASA category C recommendations (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01/09 - 2017/01/27
Concluded
 Advanced course: Biostatistics (7th Edition) (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/10/24 - 2016/11/10
Concluded
 Advanced course: Fundamentals of Genetics, Development and Neoplasia (8th Edition) (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/10/03 - 2016/10/24
Concluded
 Advanced course: Fundamentals Immunology and Infection (8th Edition) (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/09/12 - 2016/09/28
Concluded
 Advanced course: Fundamentals in Neuroscience (9th Edition) (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/09 - 2016/07
Concluded
 Bioquímica (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"The interplay between peripheral neuropathy and Tau protein in neuronal and synaptic damage in the brain" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2020/03/01 - 2022/12 Research Assistant (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/07 - 2019/05 Research Assistant (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/02 - 2016/08 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Others

Category
Host institution 		Employer
2023/01 - Current PhD Student Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2021/09 - Current Intermittent fasting as a novel therapeutical strategy for Spinocerebellar Ataxias
-
Research Technician Fellow
2020/12 - Current Serotonergic signalling activation as a therapeutic approach for neurodegenerative diseases
-
Research Technician Fellow
2020/03/01 - Current Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia
Research Fellow
Laboratório Associado ICVS 3B's, Portugal
 US Department of Defense
Ongoing
2023/01/01 - 2027/01/01 Development of over-inhibition of cortical circuits in Down Syndrome
NEURON/0001/2021
PhD Student Fellow
Laboratório Associado ICVS 3B's, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing

Other

Designation Funders
2017/06 - Current Tau as converging protein in the chronic stress and Alzheimer's disease synaptic pathologies
missing
Other
Laboratório Associado ICVS 3B's, Portugal

Universität Osnabrück, Germany
Ongoing
2016/02 - Current Clarifying the role of Tau protein biology and pathology in the mechanisms of brain damage induced by peripheral neuropathy
-
Other
Universidade do Minho Escola de Medicina, Portugal
Ongoing
2018 - 2018 Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields
Other
Outputs

Publications

Conference abstract
  1. Guerreiro, Sara; Sotiropoulos, Ioannis; Leite-Almeida, Hugo. "A novel role for Tau protein in the mechanisms of brain damage caused by peripheral neuropathy". Paper presented in ECNP Workshop for Junior Scientists,, Nice, 2018.
    Published • 10.1016/j.euroneuro.2017.12.084
Conference poster
  1. Ferreira-Lomba, Bruna; Guerreiro, Sara R.; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Motor coordination and balance ameliorated after treatment of the CMVMJD135 mouse model of Spinocerebellar Ataxia Type 3 with befiradol". Paper presented in International Congress for Ataxia Research (ICAR) 2022, 2022.
  2. Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease". Paper presented in International Society for Neurochemistry-Asian Pacific Society of Neurochemistry (ISN-APSN) meeting 2022, Honolulu, USA, 2022.
  3. Ferreira-Lomba, Bruna; Guerreiro, S. ; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al. "Pre- and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS) Forum 2022, Paris, France, 2022.
  4. Guerreiro, Sara; Ferreira-Lomba, Bruna; Duarte-Silva, S; Cunha-Garcia, Daniela ; Vidinha-Mira, André; Vilasboas-Campos, Daniela; Teixeira-Castro, Andreia; et al. Corresponding author: Maciel, Patrícia. "NLX-112 improved the motor coordination and balance in a mouse experimental model of Machado-Joseph Disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  5. Vidinha-Mira, André; Monteiro, Daniela; Guerreiro, Sara R.; Almeida, Bruno; Duarte-Silva, S; Teixeira-Castro, Andreia. "Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Diseases". Paper presented in Investigação Jovem da U.Porto (IJUP) 2021, 2021.
  6. Vidinha-Mira, André; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Vieira, Carmen ; Cunha-Garcia, Daniela ; Ferreira-Lomba, Bruna; Oliveira, Stéphanie; et al. "Does activation of serotonergic treatment suppress proteotoxicity in mouse models of neurodegenerative diseases?". Paper presented in Sixteenth - Young European Scientist (YES) Meeting, 2021.
  7. Guerreiro, Sara; Guimarães, Marco; Sousa, Raquel; Dioli, Chrysoula; Marques, Carlos; Silva, Joana Margarida; Gomes, Patricia; et al. "A novel role for Tau protein in the mechanisms of brain damage caused by peripheral neuropathy". Paper presented in 2nd EuroTau Meeting, April, Lille, France, 2018.
  8. Guerreiro, Sara; Guimarães, Marco; Sousa, Raquel; Dioli, Chrysoula; Marques, Carlos; Silva, Joana Margarida; Gomes, Patricia; et al. "A novel role for Tau protein in the mechanisms of brain damage caused by peripheral neuropathy". Paper presented in ECNP Workshop for Junior Scientists, March, Nice, France, 2018.
  9. Guerreiro, Sara; Guimarães, Marco; Sousa, Raquel; Dioli, Chrysoula; Marques, Carlos; Silva, Joana Margarida; Gomes, Patricia; et al. "A novel role for Tau protein in the mood and cognitive deficits triggered by peripheral neuropathy". Paper presented in XV SPN Meeting, May, Braga, Portugal, 2017.
Journal article
  1. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47)". The Journal of Clinical Investigation (2024):
    Published
  2. Duarte-Silva, S; DA SILVA, JORGE D.; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Mafalda Raposo; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3". The Journal of Clinical Investigation (2024): https://www.jci.org/articles/view/162246.
    In press
  3. Sara Guerreiro; Patrícia Maciel. "Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges". Cells (2023): https://doi.org/10.3390/cells12040538.
    10.3390/cells12040538
  4. Luísa Carvalho; Pedroso de Lima, Fábio; Pontes, Olívia; Oliveira-Pinto, Sofia; Cerqueira, Mónica; Ana silva; Guerreiro, Sara R.; et al. "Synthesis and Biological Evaluation of Novel Chromeno[2,3-d]Pyrimidinones as Agents for Triple Negative Breast Cancer Treatment". RSC Medicinal Chemistry (2023):
    Under revision
  5. Guerreiro, Sara R.; Guimarães, Marco R.; Silva, Joana M.; Dioli, Chrysoula; Vamvaka-Iakovou, Anastasia; Sousa, Raquel; Gomes, Patrícia; et al. "Chronic pain causes Tau-mediated hippocampal pathology and memory deficits". Molecular Psychiatry (2022): http://dx.doi.org/10.1038/s41380-022-01707-3.
    Published • 10.1038/s41380-022-01707-3
  6. Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; et al. "Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields". Translational Psychiatry 9 1 (2019): http://dx.doi.org/10.1038/s41398-019-0477-7.
    Published
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/03/29 A novel role for Tau protein in the mechanisms of brain damage caused by peripheral neuropathy Selected Oral presentation at the 14th International Conference of Alzheimer's and Parkinson diseases (AD/PD) 2019, March 2019, Lisbon, Portugal
(Lisbon, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/08/03 - 2023/08/07 2023 ISN Advanced School (2023/08/03 - 2023/08/07)
Workshop (Co-organisor)
 International Society for Neurochemistry, Switzerland
2021/01 - 2021/02/28 Rare Diseases Day 2021 (2021/02/28) Laboratório Associado ICVS 3B's, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/08/08 - 2023/08/11 ISN-ESN Meeting, Porto
Conference
 ISN-ESN Meeting, Porto
International Society for Neurochemistry, Switzerland
2021/09/16 - 2021/09/16 Seminar: "The Pathway to Improved Translation with Targeted In Vivo Modelling"
Seminar
Charles River Analytics Inc, United States
2021/05/25 - 2021/05/26 1st European Society for Neurochemistry Virtual Conference
Conference
 Future Perspectives for European Neurochemistry - a young scientists conference
2021/05/06 - 2021/05/06 Seminar: "Modelling the human brain using induced pluripotent stem cells (iPSCs)" Speaker: Anjana Nityanandam, Ph.D (Director of Operations - Stem Cell Lab, St. Jude Children's Hospital)
Seminar

Scientific expedition

Activity description Institution / Organization
2022/07/08 - 2022/07/08 Outreach activity in Caminha - Presentation about SCA3 and Neurosciences in general to students (7-14 years-old)
2020/02 - 2020/02 Outreach activity - Presentation about what a scientist do, employment options and how to successfully achieve a scientific career, to 16-18 years-old students.
Distinctions

Award

2022 Travel Fellowship for the International Society of Neurochemistry (ISN) - Asian Pacific Society of Neurochemistry (APSN) 2022 Meeting, August 28 - September 01, 2022, Honolulu, USA
2018 Travel Fellowship at the European College of Neuropsychopharmacology (ECNP) workshop for Junior Scientists, March 2018, Nice, France
European College of Neuropsychopharmacology, Netherlands