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Identification

Personal identification

Full name
Urszula Maria Orzel

Citation names

  • Orzel, Urszula

Author identifiers

Ciência ID
0F1B-735A-7287
ORCID iD
0000-0002-4002-7764

Knowledge fields

  • Exact Sciences - Physical Sciences - Molecular Physics
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Polish (Mother tongue)
Education
Degree Classification
2022/10/01 - 2026/12/01
Ongoing
 PhD in Biosciences (Doutoramento)
Major in Biochemistry
Universidade de Coimbra, Portugal
2016/10/01 - 2021/12/31
Concluded
 Applications of Physics in Biology and Medicine (Master)
Major in Molecular Design and Bioinformatics
Uniwersytet Warszawski Wydzial Fizyki, Poland
" Structure prediction of GPCR-peptide complexes using multiscale simulations " (THESIS/DISSERTATION)
 Physical Sciences
2013/10/01 - 2016/09/26
Concluded
 Applications of Physics in Biology and Medicine (Bachelor)
Major in Molecular Design and Bioinformatics
Uniwersytet Warszawski Wydzial Fizyki, Poland
" Characterisation of selected signal and metabolic pathways in synaptic plasticity " (THESIS/DISSERTATION)
 Physical Sciences
Affiliation

Science

Category
Host institution 		Employer
2022/03/01 - 2022/08/31 Research Trainee (Research) Universidade de Coimbra, Portugal
Center for Neuroscience and Cell Biology, Portugal
2017/07/01 - 2022/02/28 Research Trainee (Research) Uniwersytet Warszawski Wydzial Chemii, Poland
Uniwersytet Warszawski Wydzial Chemii, Poland
2021/01/01 - 2021/12/31 Research Trainee (Research) Polska Akademia Nauk, Poland
Mossakowski Medical Research Institute, Polish Academy of Sciences, Poland
2015/07/01 - 2015/07/28 Research Trainee (Research) Polska Akademia Nauk, Poland
Instytut Biologii Doswiadczalnej im Marcelego Nenckiego Polskiej Akademii Nauk, Poland

Others

Category
Host institution 		Employer
2022/10/01 - Current PhD candidate Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
(...)
Projects

Grant

Designation Funders
2022/12/01 - Current The structural insight into the ACE2 receptor and its role in the SARS-CoV-2 infection
2022.15349.BD
PhD Student Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/09/01 - 2021/07/01 Investigation of proteolysis and selective ligand binding to gamma-secretase complex
2016/23/B/NZ2/03247
Researcher
Narodowe Centrum Nauki
Concluded
Outputs

Publications

Book chapter
  1. "Modeling of Membrane Proteins". 371-451. Switzerland: Springer, Cham, 2018.
    Published
Conference poster
  1. "The ligand binding to the gamma-secretase complex". Paper presented in European Chemistry Conference, 2018.
Journal article
  1. Jakub Jakowiecki; Urszula Orzel; Przemyslaw Miszta; Krzysztof Mlynarczyk; Slawomir Filipek. "Conformational Changes and Unfolding of ß-Amyloid Substrates in the Active Site of ¿-Secretase". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25052564.
    10.3390/ijms25052564
  2. Urszula Orzel; Pawel Pasznik; Przemyslaw Miszta; Marcin Lorkowski; Szymon Niewieczerzal; Jakub Jakowiecki; Slawomir Filipek. "GS-SMD server for steered molecular dynamics of peptide substrates in the active site of the ¿-secretase complex". Nucleic Acids Research (2023): http://dx.doi.org/10.1093/nar/gkad409.
    10.1093/nar/gkad409
  3. "The Role of Cholesterol in Amyloidogenic Substrate Binding to the Gamma-Secretase Complex". Biomolecules 11 7 (2021): 935. https://www.mdpi.com/2218-273X/11/7/935.
    Open access • Published
  4. "Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling". Molecules 26 9 (2021): https://www.mdpi.com/1420-3049/26/9/2456.
    Open access • Published
  5. "The Hydrophobic Ligands Entry and Exit from the GPCR Binding Site-SMD and SuMD Simulations". 25 8 (2020): 1930. https://www.mdpi.com/1420-3049/25/8/1930.
    Open access • Published
Activities

Committee member

Activity description
Role 		Institution / Organization
2017/01/01 - 2017/12/01 Member of the Organizing Commitee for the International Conference Aspects of Neuroscience at the University of Warsaw, Faculty of Sciences.
Member
 Uniwersytet Warszawski Wydzial Biologii, Poland