Paulo Henrique Carrasquinho de Matos (0F14-CA4F-1358)

Curriculum Vitae

Paulo Henrique Carrasquinho de Matos

Paulo Matos graduated in Biochemistry in 1998, at the Faculty of Sciences, University of Lisbon, Portugal. After two years as a FCT research fellow at the Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA, Lisbon, Portugal), where he consolidated his scientific training, he pursued a PhD in Biochemistry and Molecular Cell Biology under the supervision of Dr. Peter Jordan (INSA) and Dr. John Collard (The Netherlands Cancer Institute, Amsterdam, The Netherlands). In 2004, he received his PhD degree by the University of Lisbon, and was awarded a Post-Doctoral fellowship by the Association for International Cancer Research (AICR, UK), followed by a second Post-Doctoral fellowship by FCT, under the supervision of Dr. Raquel Seruca (IPATIMUP, Porto, Portugal) and Dr. Peter Jordan (INSA), that he used to strengthen his scientific track record. In 2008, he earned an Associate Researcher position at INSA, within the Ciência 2007 program, and started his own independent research group. In 2013 he was awarded a FCT Investigator 2012 development grant and moved to the University of Lisbon, where he had a five-year position as Principal Investigator and Invited Professor at the Chemistry and Biochemistry Department. In 2019, he returned to INSA with a permanent research position, integrating the Oncobiology and Signal Transduction group. Paulo Matos' early research was centered on exploring the involvement of dysregulated small GTPase signaling in tumorigenesis, with a specific focus on understanding how the cancer-associated inflammatory microenvironment contributes to this dysregulation. In more recent studies, his research team expanded its investigations to encompass whole-cell and compartment-specific proteomics. This broader approach aimed at characterizing novel pathways and identify new actionable molecules to enhance the levels and function of CFTR and NIS, two epithelial channels known to be downregulated in colorectal and thyroid carcinomas, respectively. The ultimate goal is to pave the way for the development of innovative therapeutic options for these malignancies. Their latest findings have come full circle and brought their attention to how the inflammatory microenvironment reprograms the epithelial cell transcriptome. This, in turn, profoundly affects the epithelial cell proteome, leading to tumorigenic dedifferentiation. The insights brought by Paulo's research are not only contributing to a deeper understanding of the intricate mechanisms underlying cancer progression but also hold promise for the identification of potential new targets for therapeutic interventions in cancer and other chronic degenerative diseases. Paulo Matos has supervised multiple MSc and PhD students, gathered funding from several competitive grants, has published book chapters and over 65 papers in reputable international peer-reviewed journals, reaching an h-index of 25 with more than 1650 citations (according to Scopus at February 2025).

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Identification

Personal identification

Full name: Paulo Henrique Carrasquinho de Matos

Citation names

Matos, Paulo
Matos P

Author identifiers

Ciência ID: 0F14-CA4F-1358
ORCID iD: 0000-0002-9379-9696
Google Scholar ID: https://scholar.google.com/citations?user=xONCFsoAAAAJ&hl=pt-PT
Researcher Id: F-5245-2012
Scopus Author Id: 7003265109

Knowledge fields

Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2004 Concluded	PhD in Biochemistry (Doutoramento) Major in Genetics, Virology and Immunology Universidade de Lisboa Faculdade de Ciências, Portugal	Summa Cumme Laude
1998 Concluded	Biochemistry Degree (pre-Bologna) (Licenciatura) Major in Não Aplicável Universidade de Lisboa Faculdade de Ciências, Portugal	16 out of 20 points

Affiliation

Science

	Category Host institution	Employer
2024 - Current	Principal Investigator (Research)	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
	Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2019 - 2024	Auxiliary Researcher (Research)	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
	Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2013 - 2018	Contracted Researcher (Research)	Universidade de Lisboa Faculdade de Ciências, Portugal
	Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2008 - 2012	Contracted Researcher (Research)	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
	Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2014 - 2018	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Ciências, Portugal

Others

	Category Host institution	Employer
2004 - 2008	Bolseiro de Pós-Doutoramento (Post-Doc Fellow)	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

2000 - 2004	Estudante de Doutoramento (PhD Student)	Antoni van Leeuwenhoek Nederlands Kanker Instituut Centrale Kanker Bibliotheek, Netherlands

1998 - 2000	Bolseiro de Investigação (Research Fellow)	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Projects

Grant

	Designation	Funders
2023 - 2026	Exploring the cellular pathways to promote rescue of mutant CFTR protein in cystic fibrosis FFC#2/2023 Researcher Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Fondazione per La Ricerca sulla Fibrosi Cistica Ongoing

Contract

	Designation	Funders
2022 - 2027	PARC - PARTNERSHIP FOR THE ASSESSMENT OF RISKS FROM CHEMICALS 101057014 Researcher	European Union Ongoing
2023/04/14 - 2025/04/13	Repurposing of cystic fibrosis orphan drugs in the treatment of colorectal cancer TF/2023-25/PM Principal investigator Liga Portuguesa Contra o Cancro, Portugal	Liga Portuguesa Contra o Cancro Ongoing
2021/02/01 - 2023/01/31	Arrest warrant for NIS at the plasma membrane: enhancing iodide uptake in refractory thyroid cancer SPEDM/LIMBERT/2020 Co-Principal Investigator (Co-PI) Universidade de Lisboa Instituto de Saúde Ambiental, Portugal Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo Concluded
2018/10 - 2022/09	Novel signaling pathways regulating cell surface retention of epithelial choride transport proteins PTDF/BIA-CEL/28408/2017 Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	NISomics: Characterization of the sodium iodine symporter Post-translational interactome PTDC/BIA-MOL/31787/2017 Co-Principal Investigator (Co-PI) Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2022	ChlorideSignal - New signaling pathways involved in plasma membrane retention of epithelial chloride channels PTDC/BIA-CEL/28408/2017 Researcher Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Instituto de Biosistemas & Ciências Integrativas UID/Multi/04046/2019 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal Universidade do Minho, Portugal Universidade do Porto Faculdade de Ciências, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/09/09 - 2018/09/08	Rac1 signaling in human disease IF/00130/2012/CP1147/CT0001 Principal investigator Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2018	Protein networks stabilizing CFTR at the plasma membrane: an integrated interactomics approach to find novel therapeutic targets in CF BioISI/96202-P0.b/2015 Principal investigator Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	BioISI (internal Grant) Concluded
2016 - 2018	Pesquisa de novos alvos moleculares para adjuvar a correção farmacológica da F508del-CFTR PGG/055/2014 Principal investigator Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Gilead Foundation Concluded
2016 - 2018	Perturbation of the intestinal barrier function in Inflammatory Bowel Diseases: role of the Rac1b /cytokine axis GEDII 2013/04 Researcher Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal	Grupo de Estudos da Doença Inflamatória Intestinal (GEDII) Concluded
2011/01/01 - 2013/12/31	Strategic Project - UI 4046 - 2011-2012 PEst-OE/BIA/UI4046/2011 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal Universidade do Minho, Portugal Universidade do Algarve, Portugal Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2013	A novel Rac1/PAK1/BCL-6 pathway to regulate gene expression: genome-wide screening for target genes PTDC/SAU-GMG/119586/2010 Principal investigator Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01 - 2012/12	Elucidating the role of novel CFTR interactors - new mechanisms in membrane protein trafficking PTDC/BIA-BCM/112635/2009 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	Signaling mechanisms involved in actin-mediated cell surface retention of the CFTR protein BioFIG/IG2012 Principal investigator Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Portugal	BioFiG (internal Grant) Concluded
2010 - 2011	Effects of inflammation on Rac1b, a novel therapeutic target in colorectal tumors FCG96495/2009 Researcher Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Portugal	Fundação Calouste Gulbenkian Concluded
2009 - 2010	Alternative splicing confers novel signaling properties to Rac1, a role in colorectal tumor progression AICR 04/08 Post-doc Fellow Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Portugal	Association for International Cancer Research Concluded
2005 - 2007	Implications for tumor development of Rac1/Rac1b-modulated gene transcription POCI/SAU-OBS/57660/2004 Researcher Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2003 - 2004	Regulation of alternative splicing of the small GTPase Rac1 POCTI/BME/47546/2002 PhD Student Fellow Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Matos, Paulo; Pereira, JFS; Jordan, Peter. "Targeting cancer by using nanoparticles to modulate RHO GTPase signaling". In Nanotoxicology in safety assessment of nanomaterials. Springer Nature, 2022. In press • 10.1007/978-3-030-88071-2_5 Silva, Ana Luísa; Faria, Márcia; Matos, Paulo. "Inflammatory Microenvironment Modulation of Alternative Splicing in Cancer: A Way to Adapt". In Advances in Experimental Medicine and Biology, 243-258. Springer International Publishing, 2020. 10.1007/978-3-030-34025-4_13 Matos, Paulo. "Targeting Colon Cancers with Mutated BRAF and Microsatellite Instability". 2018. 10.1007/978-3-030-02771-1_2 Matos, Paulo; Gonçalves, Vânia; Jordan, Peter. "Therapeutic Approaches Targeting the Serrated Pathway of Colorectal Cancer Characterized by Mutation in the BRAF Gene and Overexpression of GTPase Rac1b". In Therapeutic Targets for Inflammation and Cancer, 233-255. WORLD SCIENTIFIC, 2017. 10.1142/9789813148574_0011 Amaral, Margarida D.; Farinha, Carlos M.; Matos, Paulo; Botelho, Hugo M.. "Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)". In Unconventional Protein Secretion, 105-126. Springer New York, 2016. 10.1007/978-1-4939-3804-9_7 Jordan, Peter; Gonçalves, Vânia; Matos, Paulo. "Alternative splicing changes regulation and signalling properties of the small GTPase Rac1". In Alternative Splicing and Cancer, 45-65. Kerala, India: Transworld Research Network, 2006. Published
Conference paper	Pinto, Fátima; Ventura, Célia; Cadete, João; Lourenço, Ana Filipa; Pedrosa, Jorge F.S.; Vital, Nádia; Pereira, Joana F.S.; et al. "Investigation of potential respiratory adverse effects of micro/nanofibrillated cellulose and cellulose nanocrystals using human lung cell lines.". 2022. Rolo, Dora; Pereira, Joana F.S; Vieira, Adriana; Roque, Rossana; Gramacho, Ana Catarina; Vital, Nádia; Matos, Paulo; et al. "Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomaterials". 2022. Vieira, Adriana; Rolo, Dora; Vital, Nádia; Martins, Carla; Assunção, Ricardo; Alvito, Paula; Gonçalves, Lídia; et al. "Titanium dioxide nanomaterials - induced DNA damage in intestinal cells following simulated in vitro digestion". 2021. Rolo, Dora; Pereira, Joana F.S.; Matos, Paulo; Gonçalves, Lídia; Bettencourt, Ana Francisca; Jordan, Peter; Silva, Maria João; Louro, Henriqueta. "Cellular effects of Titanium Dioxide Nanoparticles in the intestine". 2021. Rolo, Dora; Pereira, Joana F.S.; Matos, Paulo; Vieira, Adriana; Vital, Nádia; Jordan, Peter; Silva, Maria João; Louro, Henriqueta. "Validation of Caco-2/HT29-MTX model to assess the potential risk of ingested titanium dioxide nanoparticles". Paper presented in EMGS 2020 - Environmental Mutagenesis & Genomics Society Virtual Annual Meeting, 2020. "Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1b". Paper presented in 23rd Annual Meeting of the Portuguese Society of Human Genetics, 2020. 10.1097/MD.0000000000019291 Louro, Henriqueta; Rolo, Dora; Gramacho, Ana C.; Pereira, Joana; Matos, Paulo; Jordan, Peter; Martins, Carla; et al. "Nano-bio interactions of titanium dioxide nanomaterials in the intestinal moiety after simulated digestion in vitro". 2020. Matos, Ana Margarida; Pinto, Francisco R.; Barros, Patrícia; Amaral, Margarida D.; Pepperkok, Rainer; Matos, Paulo. "Plasma membrane-specific interactome analysis reveals calpain 1 as a druggable modulator of rescued Phe508del-CFTR cell surface stability". 2019. Ventura, Célia; Matos, Paulo; Pereira, Joana F.S.; Marques, Bárbara; Sousa-Uva, António; Silva, Maria João. "Nucleoplasmic bridges in alveolar cells induced by nanomaterial exposure". 2019. Barros, Patricia; Amaral, Andreia; Abrantes, Leonor; Oliveira, Tiago; Louro, Henriqueta; Silva, Maria Joâo; Jordan, Peter; Gama Carvalho, Margarida; Matos, Paulo. "Upregulation of RAC1/PAK1 signalling promotes DNA damage repair in colorectal cancer cells". 2018. Goncalves, V.; Matos, P.; Henriques, A. A.; Pereira, J.; Jordan, P.. "Signal transduction pathways regulating alternative splicing of tumor-related RAC1b". 2017. Pereira, Joana; Matos, Paulo; Jordan, Peter. "Stroma cell-derived signals stimulate expression of tumor-promoting RAC1B in colorectal cells". 2017. Gonçalves, Vânia; Matos, Paulo; Henriques, Andreia; Pereira, Joana; Jordan, Peter. "Lessons from Colon Cancer: How Signal Transduction Pathways Regulate Alternative Splicing of RAC1b". 2017. Gonçalves, Vânia; Matos, Paulo; Henriques, Andreia; Pereira, Joana; Jordan, Peter. "Signal Transduction Pathways Regulating Alternative Splicing of RAC1b". 2017. Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Henriques, Andreia; Jordan, Peter. "Regulation of the alternative splicing of tumor-related RAC1b by signal transduction pathways". 2017. Barros, P.; Amaral, A.J.; Abrantes, L.B.; Oliveira, T.; Louro, H.; Silva, M.J.; Jordan, P.; Gama-Carvalho, M.; Matos, P.. "Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via the BCL6/STAT5-switch". 2017. 10.1093/annonc/mdx361.069 Barros, Patrícia; Amaral, Andreia; Abrantes, Leonor; Oliveira, Tiago; Lourio, Henriqueta; Silva, Maria João; Jordan, Peter; Gama-Carvalho, Margarida; Matos, Paulo. "Activation of RAC1/PAK1 axis potentiates transcriptional upregulation of DNA damage response genes via the BCL6/STAT5 switch". 2017. Faria, Marcia; Matos, Paulo; Bugalho, Maria Joao; Silva, Ana Luisa. "Impact of RAC1/1b signalling on Sodium Iodide symporter regulation". Paper presented in 19th European Congress of Endocrinology, 2017. Published • 10.1530/endoabs.49.ep1448 Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Jordan, Peter; Henriques, Andreia. "Ibuprofen inhibits overexpression of tumor-related Rac1b through SRSF1". 2016. Pereira, Joana; Matos, Paulo; Jordan, Peter. "Effect of 2D and 3D growth conditions on expression of signalling GTPase Rac1b in colorectal cells". 2014. Henriques, Andreia; Barros, Patrícia; Matos, Paulo; Jordan, Peter. "Rac1b expression reverts B-Raf-V600E-induced senescence in colorectal cells". 2014. Gonçalves, Vânia; Henriques, Andreia; Pereira, Joana; Neves-Costa, Ana; Moyer, Pat; Ferreira Moita, Luís; Gama-Carvalho, Margarida; Matos, Paulo; Jordan, Peter. "Alternative splicing of tumour-related Rac1b in colorectal cells is regulated by protein phosphorylation of splicing factor SRSF1". 2014. Barros, Patrícia; Lam, Eric; Jordan, Peter; Matos, Paulo. "A novel Rac1/PAK1/BCL-6/STAT5 pathway modulates the expression of cell-cycle-associated genes". 2013. Barros, Patrícia; Jordan, Peter; Matos, Paulo. "Transcriptional regulation by antagonistic promoter binding of BCL-6 or Stat5 is modulated by Rac1 Signaling". 2012. Matos, Paulo; Moniz, Sónia; Moraes, Bruno; Mendes, Ana Isabel; Amaral, Margarida D.; Jordan, Peter. "Stimulation of Rac1 signalling enhances apical retention of chemically corrected F508del-CFTR in human airway cells.". 2012. Gonçalves, Vânia; Matos, Paulo; Jordan, Peter. "Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways". 2011.
Conference poster	Matos, Paulo. "Authored and co-authored over 20 posters presented at national and international meetings in the last five years.". 2025.
Journal article	Rolo, Dora; Pereira, Joana F.S.; Gonçalves, Lídia; Bettencourt, Ana; Jordan, Peter; Silva, Maria João; Matos, Paulo; Louro, Henriqueta. "Assessing the impact of TiO2 nanomaterials on intestinal cells: New evidence for epithelial translocation and potential pro-inflammatory effects". Toxicology 511 (2025): 154066. https://doi.org/10.1016/j.tox.2025.154066. Published • 10.1016/j.tox.2025.154066 Matos, Paulo; Jordan, Peter. "Alternative Splicing at the Crossroad of Inflammatory Bowel Diseases and Colitis-Associated Colon Cancer". Cancers 17 2 (2025): 219. https://doi.org/10.3390/cancers17020219. 10.3390/cancers17020219 García-Moreno, Juan F.; Matos, Paulo; Romão, Luísa. "DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal Cancer". Journal of Cellular Signaling 4 4 (2023): 169-177. http://dx.doi.org/10.33696/signaling.4.104. 10.33696/signaling.4.104 García-Moreno, Juan F.; Lacerda, Rafaela; da Costa, Paulo J.; Pereira, Marcelo; Gama-Carvalho, Margarida; Matos, Paulo; Romão, Luísa. "DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway". Cellular and Molecular Life Sciences 80 7 (2023): http://dx.doi.org/10.1007/s00018-023-04833-5. 10.1007/s00018-023-04833-5 Barros, Patrícia; Matos, Ana M.; Matos, Paulo; Jordan, Peter. "YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1". Biomolecules 13 6 (2023): 949. http://dx.doi.org/10.3390/biom13060949. 10.3390/biom13060949 Faria, Márcia; Vareda, José; Miranda, Micaella; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells". Cancers 14 21 (2022): 5362. http://dx.doi.org/10.3390/cancers14215362. 10.3390/cancers14215362 Dora Rolo; Ricardo Assunção; Célia Ventura; Alvito P; Lídia Gonçalves; Carla Martins; Bettencourt A.; et al. "Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review". Nanomaterials (2022): https://www.mdpi.com/2079-4991/12/19/3275. 10.3390/nano12193275 Joana F. S. Pereira; Cláudia Bessa; Paulo Matos; Peter Jordan. Corresponding author: Peter Jordan. "Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells". Cancers 14 6 (2022): 1393-1393. https://doi.org/10.3390/cancers14061393. Published • https://doi.org/10.3390/cancers14061393 Matos, Ana M.; Jordan, Peter; Matos, Paulo. "Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770". Frontiers in Molecular Biosciences 8 (2021): http://dx.doi.org/10.3389/fmolb.2021.812101. 10.3389/fmolb.2021.812101 Márcia Faria; Rita Domingues; Maria João Bugalho; Paulo Matos; Ana Luísa Silva. "MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells". Cancers 13 22 (2021): 5861-5861. https://doi.org/10.3390/cancers13225861. 10.3390/cancers13225861 Márcia Faria; Rita Domingues; Maria João Bugalho; Ana Luísa Silva; Paulo Matos. "Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer". Cancers (2021): https://doi.org/10.3390/cancers13215460. 10.3390/cancers13215460 Joana F. S. Pereira; Peter Jordan; Paulo Matos. "A Signaling View into the Inflammatory Tumor Microenvironment". Immuno (2021): https://doi.org/10.3390/immuno1020007. 10.3390/immuno1020007 Márcia, Faria; João, Bugalho Maria; Matos, Paulo; Luísa, Silva Ana. "Gß¿-mediated signaling regulates NIS abundance at the plasma membrane". Endocrine Abstracts (2021): http://dx.doi.org/10.1530/endoabs.73.yi11. 10.1530/endoabs.73.yi11 Paulo Matos. "Small GTPases in Cancer: Still Signaling the Way". Cancers (2021): https://doi.org/10.3390/cancers13071500. 10.3390/cancers13071500 Cláudia Bessa; Paulo Matos; Peter Jordan; Vânia Gonçalves. "Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics". International Journal of Molecular Sciences 21 23 (2020): 9032-9032. https://doi.org/10.3390/ijms21239032. 10.3390/ijms21239032 Matos, Paulo. "Ibuprofen disrupts a WNK1/GSK3ß/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells.". Oncotarget (2020): https://europepmc.org/articles/PMC7720772. 10.18632/oncotarget.27816 Faria, Márcia; Domingues, Rita; Paixão, Francisca; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "TNFa-mediated activation of NF-kB downregulates sodium-iodide symporter expression in thyroid cells". PLOS ONE 15 2 (2020): e0228794. http://dx.doi.org/10.1371/journal.pone.0228794. 10.1371/journal.pone.0228794 Ventura, Célia; Pereira, Joana F. S.; Matos, Paulo; Marques, Bárbara; Jordan, Peter; Sousa-Uva, António; Silva, Maria João. "Cytotoxicity and genotoxicity of MWCNT-7 and crocidolite: assessment in alveolar epithelial cells versus their coculture with monocyte-derived macrophages". Nanotoxicology (2020): 1-25. http://dx.doi.org/10.1080/17435390.2019.1695975. 10.1080/17435390.2019.1695975 Loureiro, Cláudia Almeida; Pinto, Francisco R.; Barros, Patrícia; Matos, Paulo; Jordan, Peter. "A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane". Cellular and Molecular Life Sciences (2020): http://dx.doi.org/10.1007/s00018-020-03448-4. 10.1007/s00018-020-03448-4 Henriques, Andreia F.A.; Matos, Paulo; Carvalho, Ana Sofia; Azkargorta, Mikel; Elortza, Felix; Matthiesen, Rune; Jordan, Peter. "WNK1 phosphorylation sites in TBC1D1 and TBC1D4 modulate cell surface expression of GLUT1". Archives of Biochemistry and Biophysics 679 (2020): 108223. http://dx.doi.org/10.1016/j.abb.2019.108223. 10.1016/j.abb.2019.108223 Faria, Márcia; Félix, Daniela; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana Luísa. "Antagonistic effects of RAC1 and tumor-related RAC1b on NIS expression in thyroid". Journal of Molecular Endocrinology 63 4 (2019): 309-320. http://dx.doi.org/10.1530/jme-19-0195. 10.1530/jme-19-0195 Matos, Ana M.; Pinto, Francisco R.; Barros, Patrícia; Amaral, Margarida D.; Pepperkok, Rainer; Matos, Paulo. "Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant". Journal of Biological Chemistry 294 36 (2019): 13396-13410. http://dx.doi.org/10.1074/jbc.ra119.008738. 10.1074/jbc.ra119.008738 Loureiro, Cláudia Almeida; Barros, Patrícia; Matos, Paulo; Jordan, Peter. "Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3". Archives of Biochemistry and Biophysics 669 (2019): 61-70. http://dx.doi.org/10.1016/j.abb.2019.05.022. 10.1016/j.abb.2019.05.022 Loureiro, Cláudia Almeida; Santos, João D.; Matos, Ana Margarida; Jordan, Peter; Matos, Paulo; Farinha, Carlos M.; Pinto, Francisco R.. "Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.00619. 10.3389/fphar.2019.00619 Jordan P; Gonçalves V; Matos P. "A new twist to Ibuprofen: alternative action in alternative splicing". Eur Med J 4 2 (2019): 64-71. https://www.emjreviews.com/oncology/article/a-new-twist-to-ibuprofen-alternative-action-in-alternative-splicing/. Published Matos, Ana M.; Gomes-Duarte, Andreia; Faria, Márcia; Barros, Patrícia; Jordan, Peter; Amaral, Margarida D.; Matos, Paulo. "Prolonged co-treatment with HGF sustains epithelial integrity and improves pharmacological rescue of Phe508del-CFTR". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-31514-2. 10.1038/s41598-018-31514-2 Matos, Ana; Matos, Paulo. "Combination therapy in Phe508del CFTR: how many will be enough?". Journal of Lung Health and Diseases 2 1 (2018): 9-16. http://dx.doi.org/10.29245/2689-999x/2017/1.1113. 10.29245/2689-999x/2017/1.1113 Farinha, Carlos M.; Matos, Paulo. "Rab GTPases regulate the trafficking of channels and transporters - a focus on cystic fibrosis". Small GTPases 9 1-2 (2017): 136-144. http://dx.doi.org/10.1080/21541248.2017.1317700. 10.1080/21541248.2017.1317700 Faria, Márcia; Matos, Paulo; Pereira, Teresa; Cabrera, Rafael; Cardoso, Bruno A.; Bugalho, Maria João; Silva, Ana Luísa. "RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells". PLOS ONE 12 2 (2017): e0172689. http://dx.doi.org/10.1371/journal.pone.0172689. 10.1371/journal.pone.0172689 Matos, Paulo; Gonçalves, Vânia; Jordan, Peter. "Targeting the serrated pathway of colorectal cancer with mutation in BRAF". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1866 1 (2016): 51-63. http://dx.doi.org/10.1016/j.bbcan.2016.06.003. 10.1016/j.bbcan.2016.06.003 Pereira, Joana F. S.; Awatade, Nikhil T.; Loureiro, Cláudia A.; Matos, Paulo; Amaral, Margarida D.; Jordan, Peter. "The third dimension: new developments in cell culture models for colorectal research". Cellular and Molecular Life Sciences 73 21 (2016): 3971-3989. http://dx.doi.org/10.1007/s00018-016-2258-2. 10.1007/s00018-016-2258-2 Henriques, Andreia F.A.; Barros, Patrícia; Moyer, Mary Pat; Matos, Paulo; Jordan, Peter. "Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells". Cancer Letters 369 2 (2015): 368-375. http://dx.doi.org/10.1016/j.canlet.2015.08.027. 10.1016/j.canlet.2015.08.027 Farinha, Carlos M.; Matos, Paulo. "Repairing the basic defect in cystic fibrosis - one approach is not enough". FEBS Journal 283 2 (2015): 246-264. http://dx.doi.org/10.1111/febs.13531. 10.1111/febs.13531 Matos, Paulo; Jordan, Peter. "Beyond Cox-Inhibition: ‘Side-Effects’ of Ibuprofen on Neoplastic Development and Progression". Current Pharmaceutical Design 21 21 (2015): 2978-2982. http://dx.doi.org/10.2174/1381612821666150514104608. 10.2174/1381612821666150514104608 Loureiro, C. A.; Matos, A. M.; Dias-Alves, Â; Pereira, J. F.; Uliyakina, I.; Barros, P.; Amaral, M. D.; Matos, P.. "A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint". Sci Signal 8 377 (2015): ra48-ra48. 10.1126/scisignal.aaa1580 Goncalves, V; Henriques, A; Pereira, J; Costa, AN; Moyer, MP; Moita, LF; Gama-Carvalho, M; et al. "Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells". Rna-a Publication of the Rna Society 20 4 (2014): 474-482. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333191300005&KeyUID=WOS:000333191300005. 10.1261/rna.041376.113. Farinha, Carlos M.; Matos, Paulo; Amaral, Margarida D.. "Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: not just from the endoplasmic reticulum to the Golgi". FEBS Journal 280 18 (2013): 4396-4406. http://dx.doi.org/10.1111/febs.12392. 10.1111/febs.12392 Matos, Paulo; Kotelevets, Larissa; Jordan, Peter; Gonçalves, Vânia; Henriques, Andreia; Zerbib, Philippe; Moyer, Mary Pat; Chastre, Eric. "Ibuprofen Inhibits Colitis-Induced Overexpression of TumorRelated Rac1b". Neoplasia 15 1 (2013): 102-111. http://dx.doi.org/10.1593/neo.121890. 10.1593/neo.121890 Moniz, Sónia; Sousa, Marisa; Moraes, Bruno José; Mendes, Ana Isabel; Palma, Marta; Barreto, Celeste; Fragata, José I.; Amaral, Margarida D.; Matos, Paulo. "HGF Stimulation of Rac1 Signaling Enhances Pharmacological Correction of the Most Prevalent Cystic Fibrosis Mutant F508del-CFTR". ACS Chemical Biology 8 2 (2012): 432-442. http://dx.doi.org/10.1021/cb300484r. 10.1021/cb300484r Vieira, Luís; Vaz, Andreia; Matos, Paulo; Ambrósio, Ana Paula; Nogueira, Manuel; Marques, Bárbara; Pereira, Ana Marques; Jordan, Peter; da Silva, Maria Gomes. "Three-way translocation (X;20;16)(p11;q13;q23) in essential thrombocythemia implicatesNFATC2in dysregulation ofCSF2expression and megakaryocyte proliferation". Genes, Chromosomes and Cancer 51 12 (2012): 1093-1108. http://dx.doi.org/10.1002/gcc.21994. 10.1002/gcc.21994 Barros, Patrícia; Lam, Eric W.-F.; Jordan, Peter; Matos, Paulo. "Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters". Nucleic Acids Research 40 16 (2012): 7776-7787. http://dx.doi.org/10.1093/nar/gks571. 10.1093/nar/gks571 Luz, S.; Kongsuphol, P.; Mendes, A. I.; Romeiras, F.; Sousa, M.; Schreiber, R.; Matos, P.; et al. "Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity". Molecular and Cellular Biology 31 22 (2011): 4392-4404. http://dx.doi.org/10.1128/mcb.05517-11. 10.1128/mcb.05517-11 Mendes, A.I.; Matos, P.; Moniz, S.; Luz, S.; Amaral, M.D.; Farinha, C.M.; Jordan, P.; et al. "Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase". Molecular and Cellular Biology 31 19 (2011): 4076-4086. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053611644&partnerID=MN8TOARS. 10.1128/MCB.05152-11 Mendes, Ana Isabel; Matos, Paulo; Moniz, Sónia; Jordan, Peter; Mendes, A.I.; Matos, P.; Moniz, S.; Jordan, P.. "Protein Kinase WNK1 Promotes Cell Surface Expression of Glucose Transporter GLUT1 by Regulating a Tre-2/USP6-BUB2-Cdc16 Domain Family Member 4 (TBC1D4)-Rab8A Complex". Journal of Biological Chemistry 285 50 (2010): 39117-39126. http://dx.doi.org/10.1074/jbc.m110.159418. 10.1074/jbc.m110.159418 Dias, E.; Matos, P.; Pereira, P.; Batoréu, M.C.C.; Silva, M.J.; Jordan, P.. "Microcystin-LR activates the ERK1/2 kinases and stimulates the proliferation of the monkey kidney-derived cell line Vero-E6". Toxicology in Vitro 24 6 (2010): 1689-1695. http://dx.doi.org/10.1016/j.tiv.2010.05.018. 10.1016/j.tiv.2010.05.018 Velho, Sérgia; Oliveira, Carla; Paredes, Joana; Sousa, Sónia; Leite, Marina; Matos, Paulo; Milanezi, Fernanda; et al. "Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours". Human Molecular Genetics 19 4 (2009): 697-706. http://dx.doi.org/10.1093/hmg/ddp536. 10.1093/hmg/ddp536 Gonçalves, Vânia; Matos, Paulo; Jordan, Peter. "Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways". Human Molecular Genetics 18 19 (2009): 3696-3707. http://dx.doi.org/10.1093/hmg/ddp317. 10.1093/hmg/ddp317 Barros, Patri´cia; Jordan, Peter; Matos, Paulo; Barros, P.; Jordan, P.; Matos, P.. "Rac1 Signaling Modulates BCL-6-Mediated Repression of Gene Transcription". Molecular and Cellular Biology 29 15 (2009): 4156-4166. http://dx.doi.org/10.1128/mcb.01813-08. 10.1128/mcb.01813-08 Seruca, Raquel; Velho, Sérgia; Oliveira, Carla; Leite, Marina; Matos, Paulo; Jordan, Peter. "Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors". Expert Review of Gastroenterology & Hepatology 3 1 (2009): 5-9. http://dx.doi.org/10.1586/17474124.3.1.5. 10.1586/17474124.3.1.5 Goncalves, V.; Matos, P.; Jordan, P.. "The -catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression". RNA 14 12 (2008): 2538-2549. http://dx.doi.org/10.1261/rna.1253408. 10.1261/rna.1253408 Moniz, Sónia; Matos, Paulo; Jordan, Peter. "WNK2 modulates MEK1 activity through the Rho GTPase pathway". Cellular Signalling 20 10 (2008): 1762-1768. http://dx.doi.org/10.1016/j.cellsig.2008.06.002. 10.1016/j.cellsig.2008.06.002 Matos, Paulo; Oliveira, Carla; Velho, Sérgia; Gonçalves, Vânia; da Costa, Luís Teixiera; Moyer, Mary Pat; Seruca, Raquel; Jordan, Peter. "B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival". Gastroenterology 135 3 (2008): 899-906. http://dx.doi.org/10.1053/j.gastro.2008.05.052. 10.1053/j.gastro.2008.05.052 Matos, Paulo; Jordan, Peter. "Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival". Molecular Cancer Research 6 7 (2008): 1178-1184. http://dx.doi.org/10.1158/1541-7786.mcr-08-0008. 10.1158/1541-7786.mcr-08-0008 Moniz, S; Veríssimo, F; Matos, P; Brazão, R; Silva, E; Kotevelets, L; Chastre, E; Gespach, C; Jordan, P. "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2". Oncogene 26 41 (2007): 6071-6081. http://dx.doi.org/10.1038/sj.onc.1210706. 10.1038/sj.onc.1210706 Chartier, N. T.. "Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells". Journal of Cell Science 119 1 (2006): 31-46. http://dx.doi.org/10.1242/jcs.02698. 10.1242/jcs.02698 Vieira, L.; Sousa, A.C.; Matos, P.; Marques, B.; Alaiz, H.; Ribeiro, M.J.; Braga, P.; Da Silva, M.G.; Jordan, P.. "Three-way translocation involves MLL, MLLT3, and a novel cell cycle control gene, FLJ10374, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3)". Genes Chromosomes and Cancer 45 5 (2006): 455-469. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645814404&partnerID=MN8TOARS. 10.1002/gcc.20311 Matos, P.; Jordan, P.; Matos, Paulo; Jordan, Peter. "Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells". Journal of Biological Chemistry 281 19 (2006): 13724-13732. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744965194&partnerID=MN8TOARS. 10.1074/jbc.M513243200 Madureira, Patrícia A.; Matos, Paulo; Soeiro, Inês; Dixon, Linda K.; Simas, J. Pedro; Lam, Eric W.-F.; Madureira, P.A.; et al. "Murine ¿-Herpesvirus 68 Latency Protein M2 Binds to Vav Signaling Proteins and Inhibits B-cell Receptor-induced Cell Cycle Arrest and Apoptosis in WEHI-231 B Cells". Journal of Biological Chemistry 280 45 (2005): 37310-37318. http://dx.doi.org/10.1074/jbc.m507478200. 10.1074/jbc.m507478200 Matos, Paulo; Jordan, Peter. "Expression of Rac1b stimulates NF-¿B-mediated cell survival and G1/S progression". Experimental Cell Research 305 2 (2005): 292-299. http://dx.doi.org/10.1016/j.yexcr.2004.12.029. 10.1016/j.yexcr.2004.12.029 Matos, P.; Collard, J.G.; Jordan, P.; Matos, Paulo; Collard, John G.; Jordan, Peter. "Tumor-related Alternatively Spliced Rac1b Is Not Regulated by Rho-GDP Dissociation Inhibitors and Exhibits Selective Downstream Signaling". Journal of Biological Chemistry 278 50 (2003): 50442-50448. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347379871&partnerID=MN8TOARS. 10.1074/jbc.M308215200 Matos, Paulo; Isidro, Glória; Vieira, Estér; Lacerda, Ana Forjaz; Martins, António Gentil; Boavida, Maria Guida. "P73 EXPRESSION IN NEUROBLASTOMA: A ROLE IN THE BIOLOGY OF ADVANCED TUMORS?". Pediatric Hematology and Oncology 18 1 (2001): 37-46. http://dx.doi.org/10.1080/088800101750059846. 10.1080/088800101750059846 Jordan, Peter; Matos, Paulo; Veri´ssimo, Fátima. "Gene Cloning at the Computer Screen: Possibilities and Problems". Biochemical and Biophysical Research Communications 279 3 (2000): 741-743. http://dx.doi.org/10.1006/bbrc.2000.3901. 10.1006/bbrc.2000.3901 Matos, Paulo; Skaug, Jennifer; Marques, Bárbara; Beck, Sebastian; Veríssimo, Fátima; Gespach, Christian; Boavida, Maria Guida; Scherer, Stephen W.; Jordan, Peter. "Small GTPase Rac1: Structure, Localization, and Expression of the Human Gene". Biochemical and Biophysical Research Communications 277 3 (2000): 741-751. http://dx.doi.org/10.1006/bbrc.2000.3743. 10.1006/bbrc.2000.3743 Isidro, G.; Veiga, I.; Matos, P.; Almeida, S.; Bizarro, S.; Marshall, B.; Baptista, M.; et al. "Four novel MSH2 / MLH1 gene mutations in Portuguese HNPCC families". Human Mutation 15 1 (2000): 116-116. http://dx.doi.org/10.1002/(sici)1098-1004(200001)15:1<116::aid-humu24>3.0.co;2-q. 10.1002/(sici)1098-1004(200001)15:1<116::aid-humu24>3.0.co;2-q Isidro, G.; Matos, P.; Almeida, S.; Claudino, S.; Marshall, B.; Soares, J.; Leite, J.; et al. "Eleven novel APC mutations identified in Portuguese FAP families.". Human mutation 16 2 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-17144444916&partnerID=MN8TOARS.
Journal issue	Matos, Paulo. "Role of Small GTPase Signaling in Tumorigenesis". Cancers (ISSN 2072-6694) (2021): https://www.mdpi.com/journal/cancers/special_issues/GTPase_Tumorigenesis#editors. Invited editor
Newsletter article	Serrenho, Inês; Vital, Nádia; Rolo, Dora; Joana R. P. Pereira; Matos, Paulo; Jordan, Peter. "Efeitos da aflatoxina B1 na integridade e morfologia de células intestinais", Boletim Epidemiológico Observações, 2023, http://hdl.handle.net/10400.18/8746.

Intellectual property

Provisional application for patent

2012. "MECHANISM OF RAC1 SIGNALING EVIDENCES HOW TO ENHANCE PHARMACOLOGICAL CORRECTION OF MISFOLDED CFTR THROUGH HGF FOR TREATMENT OF CYSTIC FIBROSIS".
2011. "RAC1 SIGNALLING STIMULATION RESCUES F508DEL-CFTR PLASMA MEMBRANE EXPRESSION AND FUNCTION IN HUMAN AIRWAYS CELLS: A NOVEL THERAPEUTIC APPROACH FOR CYSTIC FIBROSIS".

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/06/07	Novel regulators to enhance CFTR trafficking and membrane stability	47th European Cystic Fibrosis Conference European Cystic Fibrosis Society (ECFS) (Glasgow, United Kingdom)
2024/05/24	Novel regulatory pathways that can enhance F508del-CFTR rescue in Cystic Fibrosis	SINAL 2024 - 11th international meeting on Signal transduction University of Coimbra, Faculty of medicine (Coimbra, Portugal)
2023	Pathway and other NIS Plasma Membrane Interactors in NIS Regulation.	45th Annual Meeting of the European Thyroid Association European Thyroid Association (Milan, Italy)
2022	tRACing NIS Regulation in Thyroid Cancer	BioISI Research Seminar BioISI - Biosystems and Integrative Sciences Institute · Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2021	Gß¿-mediated signaling regulates NIS abundance at the plasma membrane	23rd European Congress of Endocrinology European Society of Endocrinology (Event online)
2019	Using confocal microscopy for monitoring the subcellular impact of nanomaterials.	Workshop: Nanotoxicology in the context of the safety assessment of nanomaterials Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2017	Signaling the functional rescue of mutant CFTR in cystic fibrosis.	SINAL 2017 - 8th Meeting on Signal Transduction (Lisboa, Portugal)
2017	Activation of RAC1/PAK1 axis potentiates transcriptional up-regulation of DNA damage response genes via the BCL6/STAT5-switch.	SINAL 2017 – 8th Meeting on Signal Transduction (Lisboa, Portugal)
2017	Unraveling the Signaling Pathways Influencing the NIS regulation.	5th EYES (European Young Endocrine Scientists) Meeting (Porto, Portugal)
2017	Lessons from Colon Cancer: How Signal Transduction Pathways Regulate Alternative Splicing of RAC1b.	2nd Young Investigator Day, INSA RJ (Lisboa, Portugal)
2016	Rescue of mutant CFTR function in cystic fibrosis: a multi-task job?	1st CEDOC Symposium on Chronic Diseases (Lisboa, Portugal)
2015	Overexpression of Rac1b in colorectal cancer: another "path" for tumor progression?	UIPM Seminars. Instituto Português de Oncologia de Lisboa, Francisco Gentil (Lisboa, Portugal)
2014	HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent Cystic Fibrosis mutant F508del-CFTR.	11th ECFS Basic Science Conference (St. Julians, Malta)
2013	A novel Rac1-regulated transcriptional switch: implications for colon cancer cell reprogramming.	SINAL 2013 - 7th National Meeting on Cell Signalling (Aveiro, Portugal)
2012	Stimulation of Rac1 signaling enhances apical retention of chemically corrected F508del-CFTR in human airway cells.	SINAL 2012 - 6th National Meeting on Cell Signalling (Braga, Portugal)
2012	Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-associated target gene promoters.	FEBS Workshop: Dynamics of Cell Signal System (Oslo, Norway)
2007	Rac-1b and BRafV600E Cooperate to Maintain Transformation of Colorectal Cancer Cells	11th Meeting of the Portuguese Society for Human Genetics (Porto, Portugal)
2007	Can alternative spliced Rac1b and mutant B-Raf cooperate in colorectal tumorigenesis?	IPATIMUP Seminars (Porto, Portugal)
2003	Alternative splicing alters the signaling properties of Rac1 GTPase.	Euresco Conferences: Molecular Biology of Cellular Interactions (Obernai, France)
2002	Alternative Splicing interferes with signal transduction by the small GTPase Rac1.	XIII Congresso Nacional de Bioquímica (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - 2025	Evaluation of Pro-Inflammatory Effects After Exposure of Cellular Models to Bisphenol Compounds Supervisor	Biologia Humana e Ambiente (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2024 - 2025	Development of a Functional Assay to Evaluate the Pathogenicity of Genetic Variants Found in Genes Associated with Hereditary Colon Cancer Supervisor	Biologia Humana e Ambiente (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2023 - 2025	Repurposing of CFTR modulator drugs in the context of colorectal cancer Supervisor	Biologia Humana e Ambiente (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2022 - 2024	The role of adapter protein SHC-1 in epithelial chloride transport and cell proliferation Supervisor	Bioquimica e Biomedicina (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2024	Targeting RAC1- signaling to enhance iodide-related cancer therapy Supervisor	Biologia (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2023	The involvement of DIS3L2 in nonsense-mediated mRNA decay and its functional networks in cancer Co-supervisor	Biologia (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020	New pathways involved in the regulation of epithelial chloride transport Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2018	Search for new modulators of Phe508del-CFTR retention at the plasma membrane of epithelial cells Supervisor	Biologia (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017	Caracterização dos domínios da proteína adaptadora Ezrin, essenciais à estabilização membranar do canal F508del-CFTR Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017	Validação de genes alvo da via Rac1/PAK1-BCL6/STAT5 envolvidos na progressão tumoral Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015	Estudos dos efeitos do tratamento com rhHGF de células epiteliais brônquicas derivadas de doentes com fibrose quística: avaliação das propriedades regenerativas versus oncogénicas Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2015	Desenvolvimento de um biossensor molecular para o estudo translacional da fibrose quística e outras doenças respiratórias Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010	Study of CFTR delivery and stabilization at the plasma membrane. Co-supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024	Exploring Epithelial Mesenchymal-Transition (EMT)-associated factors in Cystic Fibrosis. (Thesis) Main arguer	Raquel Gonçalves Torres (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2024	MCT1 a Peon in Metabolic Adaptation and a Crucial Target in Lung Cancer (Thesis) Main arguer	Cindy Alexandra Lopes Mendes (PhD) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2024	Lysosome exocytosis as a therapeutic target to impair breast cancer progression (Thesis) Main arguer	Ana Rita Vieira Lourenço Henriques Rodrigues (Master) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2024	Understanding the importance of death receptors in the therapeutic resistance of myeloproliferative neoplasms (Thesis) Main arguer	Carla Micaela Veiga Semedo (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024	Characterizing the regulation of the CFTR protein by the kinase GRK5 in cystic fibrosis models (Thesis) Main arguer	Mariana Ferreira Caleiro (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2023	Evaluation of the effect of specific molecular targets on plasma membrane abundance and retention of sodium iodide symporter (NIS) (Thesis) Main arguer	Maria João de Gusman Geraldes Correia Coelho (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2023	Modulating membrane traffic regulators to impair breast cancer progression (Thesis) Main arguer	Andreia Teixeira Ferreira (PhD) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023	Molecular mechanisms of melanin internalization and processing in keratinocytes (Thesis) Arguer	Matilde Roquete Viana Neto (PhD) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022	Discovery of tissue specific network properties associated with cancer driver genes (Thesis) Main arguer	Filipa Alexandra Veiga Marques Alvares Pereira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/06	Regulation of CFTR membrane stability - cross-talk between signalling pathways and the cytoskeleton (Thesis) Main arguer	João Frederico Santos Fernandes e Coelho Ferreira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/11/25	Role of CFTR in epithelial differentiation by functional genomics (Thesis) Arguer	Luis Miguel dos Santos Sousa (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2019	Analysis of translation of 5' untranslated regions in cancer (Thesis) Main arguer	Joana Filipa Pires Silva (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2018	Study on the regulation of the expression of alternative protein isoforms involved in carcinogenesis (Thesis) Main arguer	Bruna Filipa Francisco Pereira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2018	Identification of Arl13b GTPase-activating proteins towards the impairment of tumor progression (Thesis) Main arguer	Inês Margarida Castro Ferreira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2018	Identification and characterization of Internal Ribosome Entry Sites (IRES) in cancer pathways (Thesis) Main arguer	Ana Rita Rodrigues Neves (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2016	Non-canonical translation initiation of proteins with potential relevance in colorectal cancer (Thesis) Arguer	Rafaela Lacerda Santos (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015	Effect of TGFß signalling on CFTR protein: consequences for epithelial differentiation in CF (Thesis) Main arguer	Margarida Cuco Quaresma (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2010	Estabelecimento de um novo modelo in vitro do epitélio gástrico humano para o estudo dos mecanismos moleculares da infecção por Helicobacter pylori (Thesis) Main arguer	Kathy Daniella Saraiva Pava (Master) Universidade Católica Portuguesa, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2020 - Current	Reviewer of over 35 articles in the last 10 years, for Journals such as, Cells, Oncogene, Cancers, Molecules, Cellular Signalling, iScience, Biochemical Genetics, Biomolecules, Int. J. Mol. Sci., Plos, among others	Cell Press, Elsevier, MDPI, Springer-Nature, among others

Committee member

	Activity description Role	Institution / Organization
2020 - 2020	Evaluation Committee for Grant Call "Translational Research to Develop Methods for Testing Drug Conformity / Toxicity as a Pre-Therapeutic Basis for Personalized Medicine". Member	Israel Ministry of Innovation Science & Technology, Israel
2018 - 2018	Evaluation Committee for Grant Program "Approches « Single cell » pour l'étude des processus oncogéniques". Member	INSERM, France
2013 - 2015	Member of the Biomedicine Evaluation Panel for PhD and Post-Doc Research Studentships. Member	Fundação para a Ciência e a Tecnologia, Portugal

Distinctions

Award

2021	Edward Limbert Award - MERCK/SPEDM
2021	Young Investigator Award 2021 European Society of Endocrinology, United Kingdom
2006	Young Investigator Award Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Other distinction

2013	2012 FCT Investigator program - Development Grant Fundação para a Ciência e a Tecnologia, Portugal
2005	Post-doctoral Fellowship SFRH/BPD/20531/2004 Fundação para a Ciência e a Tecnologia, Portugal
2004	Post-doctoral Fellowship AICR 04-008 Association for International Cancer Research, United Kingdom
2000	Short-Term Fellowship ASTF No. 9651 European Molecular Biology Laboratory, Germany
2000	PhD Fellowship Praxis XXI/BD/21381/99 Fundação para a Ciência e a Tecnologia, Portugal