Personal identification

Full name

Madalena Maria Vilela Pimentel

Citation names

• Pimentel, Madalena

Author identifiers

Ciência ID

0F14-3779-9926

ORCID iD

0000-0002-4598-1290

Addresses

• Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa. Av Prof Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

• Medical and Health Sciences - Health Sciences
• Natural sciences - Biological Sciences - Microbiology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)		Upper intermediate (B2)	Upper intermediate (B2)

	Degree	Classification
2019/12/19 Concluded	Farmácia (Título de Agregado) Major in Microbiologia Universidade de Lisboa Faculdade de Farmácia, Portugal	Aprovada por Unanimidade
2000/04/17 Concluded	Farmácia (Doutoramento) Major in Microbiologia Universidade de Lisboa Faculdade de Farmácia, Portugal "Biologia Molecular da Resistência à Superinfecção por Bacteriofagos:Estudo do Gene pin do Micobacteriofago Ms6" (THESIS/DISSERTATION)	Aprovado com distinção e louvor
1990 Concluded	Provas Aptidão Pedagógica e Científica (Outros) Major in Microbiologia Universidade de Lisboa Faculdade de Farmácia, Portugal
1985 Concluded	Ciências Farmacêuticas/Análises Químico-Biológicas (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal	15 valores

Science

	Category Host institution	Employer
2015 - Current	Researcher (Research)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2000 - 2014	Researcher (Research)	Universidade de Lisboa, Faculdade de Farmácia/Associação para o Desenvolvimeto do Ensino e Investigação da Microbiologia/CPM-Unidade dos Retrovirus e Infeções Associadas, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2023/05 - Current	Full Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - Current	Associate Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

	Category Host institution	Employer
2021 - Current	Membro da Comissão Executiva do Departamento de Farmácia, Farmacologia e Tecnologias em Saúde	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2026	Secretária do Conselho de Escola da FFUL (2022-2026)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Contract

	Designation	Funders
2018 - Current	Clinical significance of Mycobacterium tuberculosis cell wall structural diversity: contribution to novel mechanisms of antibiotic resistance and relevance towards tuberculosis progression and treatment PTDC/BIA-MIC/31233/2017 Researcher Faculdade de Farmácia de Lisbia/FarmID, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/01/31 - 2024/07/30	AntibacML: Harnessing shared chemical and activity patterns in antimicrobial compounds to build improved computational models for the discovery of new antibiotics 2022.03752.PTDC 10.54499/2022.03752.PTDC Researcher Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/09/01 - 2022/04/30	FuFighters Fusion of complementary antibacterial functions as a new strategy to generate alternative agents to fight antibiotic-resistant pathogens PTDC/EMD-EMD/28109/2017 Co-Principal Investigator (Co-PI) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	Instituto de Investigação do Medicamento UID/DTP/04138/2019 Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/01/15 - 2015/09/30	Exploring the Mycobacteriophage lysis proteins to destroy the Mycobacteria Cell envelope PTDC/IMI-MIC/0694/2012 Principal investigator Universidade de Lisboa, Faculdade de Farmácia/Associação para o Desenvolvimeto do Ensino e Investigação da Microbiologia/CPM-Unidade dos Retrovirus e Infeções Associadas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Projecto Estratégico - UI 775 - 2011-2012 PEst-OE/SAU/UI0775/2011 Universitat Autònoma de Barcelona, Spain Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/07/01 - 2010/12/31	Characterization of the mycobacteriophages lytic genes with antimicrobial activity on mycobacteria PTDC/SAU-FCF/73017/2006 Principal investigator Universidade de Lisboa, Faculdade de Farmácia/Associação para o Desenvolvimeto do Ensino e Investigação da Microbiologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2003/04/15 - 2007/02/28	Functional Analysis of Micobacteriophages Ms6 genes involved in Mycobacteria cell lysis POCTI/ESP/ 47723/2002 Principal investigator Universidade de Lisboa, Faculdade de Farmácia/Associação para o Desenvolvimeto do Ensino e Investigação da Microbiologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2024/01/01 - 2025/01/01	Phage4Wound– Phage-based wound dressings iDEA2324 Co-Principal Investigator (Co-PI) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Ongoing

Publications

Book chapter	Pimentel, Madalena. "Genetics of Phage Lysis". United States, 2014. doi:10.1128/9781555818845
Conference abstract	Catalão, Maria João; Rosado, Helena; Pimentel, Madalena; Moniz-Pereira, José. "Changes in the DNA sequence of MS6 bacteriophage attP-int region allows site-specific recombination into the three tRNA Ala genes of M. bovis BCG". Paper presented in 2nd Congress of the Pharmaceutical Sciences_ Revista Portuguesa de Farmácia, Coimbra, 2005. Published Rosado, Helena; Catalão, Maria João; Pimentel, Madalena; Moniz-Pereira, José. "Construction of a new system for DNA expression in Mycobacteria". Paper presented in 2nd Congress of the Pharmaceutical Sciences_ Revista Portuguesa de Farmácia, 2005. Brízio, A; Da Silva, G.; Duarte, A; Pimentel, Madalena. "Transduction of imipenem resistance by bacteriophages carried by Pseudomonas aeruginosa clinical isolates". Paper presented in 7th European Congress of Chemotherapy and Infection, Florença, 2005. Published Pimentel, Madalena; Rodrigues, Lénia; Moura, Rita; Vital, João; Garcia, Miguel; Moniz-Pereira, José. "Cloning and expression of Mycobacteriophage Ms6 Lytic genes in E.coli.". Paper presented in 1st Congress of the Pharmaceutical Sciences_ Revista Portuguesa de Farmácia, Lisboa, 2003. Published Pimentel, Madalena; Garcia, Miguel,; Moniz-Pereira, José. "Identification of a mycobacteriophage Ms6 DNA gene that confers inhibition to superinfection". Paper presented in 19th Annual Congress of the European Society of Mycobacteriology-Revista Portuguesa de Pneumonologia, Lisboa, 1998. Published Garcia, Miguel; Pimentel, Madalena; Moniz-Pereira, José. "Characterization of a mycobacteriophage Ms6 promoter region". Paper presented in 19th Annual Congress of the European Society of Mycobacteriology-Revista Portuguesa de Pneumonologia, Lisboa, 1998. Published
Conference poster	) Olivença F, Nunes A, Macedo R, Pires D, Silveiro C, Ferreira C, Miragaia M, Pimentel M, Anes E, Gomes JP, Catalão MJ. "WGS-based dual strategy for the identification of key targets to enhance beta-lactam activity in Mycobacterium tuberculosis". Paper presented in ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, 2022. Ribeiro, HM, Ruas A, Graça A, Marto J, Oliveira A, Nogueira da Silva A, Pimentel M, Moura A, Figueiredo AC. "Bioactivity and Sensory Evaluation of Portuguese essential oils obtained from logging residues and thinnings". Paper presented in 32nd IFSCC (International Federation of Societies of Cosmetic Chemists) Congress 2022, 2022. Olivença F, Gigante AM, Catalão MJ, Leandro P, Moniz-Pereira J, Filipe SR, Pimentel M. "Mycobacteriophage Ms6 Pin protein is involved in a superinfection exclusion mechanism". Paper presented in VI Viruses of Microbes Meeting (VoM2022), 2022. Rosa, C; Domingos, A; Asada, M; Pimentel, Madalena; Antunes, S. "Development of Methods for Babesia ovis Genetic Manipulation". Paper presented in International Congress on Tropical Veterinary Medicine and 2nd Joint AITVM-STVM Meeting, 2018. Olivença, Francisco; Catalão, Maria João; Moniz-Pereira, José; Pimentel, Madalena. "Ms6 Pin Protein: The Role on a Mycobacteriophage Resistance Mechanism". Paper presented in 10th iMed.ULisboa Postgraduate Students Meeting & 3rd i3DU Meeting, 2018. Gigante, Adriano M; Hampton C; Dillard, RS; Wright ER; Moniz-Pereira, José; Pimentel, Madalena. "Mycobacteriophage Ms6 LysB: an essential lysis protein for an efficient lysis". Paper presented in Molecular Genetics of Bacteria and Phages Meeting, 2016. Gigante, Adriano M; Hampton C; Dillard, RS; Moniz-Pereira, José; Wright, ER; Pimentel, Madalena. "Mycobacteriophage Ms6: role of LysB on host cell lysis assessed by Cryo-Electron Microscopy". Paper presented in Microbiotec'15, 2015. Pombo, Sofia; Martins, Francisco; Gigante, Adriano M; Moniz-Pereira, José; Pimentel, Madalena. "Construction of recombinant Mycobacteriophage Ms6 expressing Green Fluorescent Protein using BRED technology". Paper presented in Viruses of Microbes III, 2014. Gigante, Adriano M; Martins, Francisco; Moniz-Pereira, José; Pimentel, Madalena. "The impact of Ms6 LysB in mycobacteria phage-mediated lysis". Paper presented in Viruses of Microbes III, 2014. Martins, Francisco; Gigante, Adriano M; Moniz-Pereira, José; Pimentel, Madalena. "Exploring mycobacteriophage-induced lysis: subcellular localization of the Ms6 endolysin LysA and its chaperone". Paper presented in Viruses of Microbes III, 2014. Gigante, Adriano M; Martins, Francisco; Moniz-Pereira, José; Pimentel, Madalena. "The impact of Ms6 LysB in mycobacteria phage-mediated lysis". Paper presented in Microbiotec'13, 2013. Martins, Francisco; Gigante, Adriano M; Moniz-Pereira, José; Pimentel, Madalena. "Contribution of Ms6 Gp1 to Mycobacterium smegmatis lysis". Paper presented in Microbiotec'13, 2013. Pimentel, Madalena; Catalão, Maria João; Gil, Filipa; Martins, Francisco; Pinheiro-Torres, Beatriz; McNeil, M.R.; Moniz-Pereira, José. "Mycobacteriophage Ms6: New insights into the mechanisms of lysis". Paper presented in Viruses of Microbes II, 2012. Proença, D; Leandro, C.; Silva, F; Santos, S.; Lopes, F; Mato, R; Cavaco-Silva, P.; et al. "Genome sequence analysis and functional study of the endolysins of two bacteriophages with broad lytic spectrum against Enterococcus faecalis clinical strains". Paper presented in Viruses of Microbes II, 2012. Proença, D; Pimentel, Madalena; Lopes, F; Mata, R; Garcia, Miguel; São-José, C. "Cell wall activity of two endolysins targeting enterococcal clinical strains". Paper presented in The Great Wall Symposium: The Dynamics of Peptidoglycan Strucutre and Function: new Insights into the ‘Great Wall, 2011. Fernandes, S; Cantante, C.; Pimentel, Madalena; Lencastre, H. "Novel chimerical endolysins with broad antimicrobial activity against MRSA". Paper presented in The Great Wall Symposium: The Dynamics of Peptidoglycan Strucutre and Function: new Insights into the ‘Great Wall, 2011. Catalão, Maria João; Gil,Filipa; McNeil, M.R.; Moniz-Pereira, José; Pimentel, Madalena. "Bacteriophage Ms6 encodes enzymes that target the cell envelope of mycobacteria". Paper presented in The Great Wall Symposium: The Dynamics of Peptidoglycan Strucutre and Function: new Insights into the ‘Great Wall, 2011. Fernandes, S; Cantante, C; Pimentel, Madalena; Lencastre, H; São-José, C. "Novel chimerical phage endolysins with antimicrobial activity against MRSA and other pathogenic Gram-positive bacteria". Paper presented in Irish Branch Meeting: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine, 2011. Proença, D; Pimentel, Madalena; Lopes, F; Mata, R; Garcia, Miguel; São-José, C. "Phage endolysins with antimicrobial activity against enterococcal clinical isolates". Paper presented in Irish Branch Meeting: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine, 2011. Catalão, Maria João; Gil, F; Moniz-Pereira, José; Pimentel, Madalena. "Functional Analysis of the Holin-Like Proteins of Mycobacteriophage Ms6". Paper presented in Irish Branch Meeting: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine, 2011. Catalão, Maria João; Milho, C.; Gil, Filipa; Piechota, C.; McNeil, M.R.; Moniz-Pereira, José; Pimentel, Madalena. "The Ms6 phage LysA is an amidase endolysin with activity against Gram positive bacteria". Paper presented in Viruses of Microbes, Institut Pasteur, Paris,, 2010. Gil, F; Grzegorzewicz, A; Catalão, M.J.; Vital, João; McNeil, M.R.; Pimentel, Madalena. "The mycobacteriophage Ms6 encodes an additional lysis protein (LysB) that targets the outer membrane of Mycobacterium smegmatis". Paper presented in Viruses of Microbes, Institut Pasteur, Paris, France, 2010. Gil, Filipa; Grzegorzewicz, A; Catalão, Maria João; Vital, João; McNeil, M.R.; Pimentel, Madalena. "Mycobacteriophage Ms6 LysB specifically targets the outer membrane of Mycobacterium smegmatis". Paper presented in Microbiotec'09, 2009. Catalão, Maria João; Gil, Filipa; Moniz-Pereira, José; Pimentel, Madalena. "The Mycobacteriophage Ms6 Endolysin Reaches Its Target Assisted by Gp1, a Chaperone-Like Protein". Paper presented in 109th General Meeting of the American Society for Microbiology., 2009. Gil, Filipa; Catalão, Maria João; Vital, João; Moniz-Pereira, José; McNeil, M.R.; Pimentel, Madalena. "LysB: A Lipolytic Enzyme Encoded within the Lysis Module of the Mycobacteriophage Ms6.". Paper presented in 108th General Meeting of the American Society for Microbiology, 2008. Catalão, Maria João; Gil, Filipa; Moniz-Pereira, José; Pimentel, Madalena. "A chaperone-like protein is involved in the translocation of the mycobacteriophage Ms6 endolysin". Paper presented in Micro-Biotec-XXXIII, 2007. Gil, Filipa; Catalão, Maria João; Vital, João; Moniz-Pereira, José; McNeil, M.R.; Pimentel, Madalena. "Mycobacteriophage Ms6 LysB: the first lipase described from a bacteriophage". Paper presented in Micro-Biotec-XXXIII JPG 2007, 2007. "A Phage Lytic Enztme from Mycobacteriophage Ms6 has Antibacterial Activity". Paper presented in 12th International Congress of Infectious Diseases, 2006. Gil, Filipa; Catalão, Maria João; Vital, João; Moniz-Pereira, José; McNeil, M.R.; Pimentel, Madalena. "Analysis of the lysis genes lysA and lysB of the mycobacteriophage Ms6". Paper presented in 106th General Meeting of the American Society for Microbiology, 2006. Pimentel, Madalena; Gil, Filipa; Vital, João; Moniz-Pereira, José. "Role of the lytic genes from micobacteriophage Ms6 in cell lysis". Paper presented in Keystone Symposia, Tuberculosis: Integrating Host and Pathogen Biology, 2005. Pimentel, Madalena; Gil, Filipa; Vital, João; Moniz-Pereira, José. "Overexpression of gene gp1 of the mycobacteriophage Ms6 lytic cassette causes a lethal effect in E. coli". Paper presented in ASM Conference: The New Phage Biology, 2004. "Genes from the Lytic Operon of Mycobacteriophage Ms6 can induce a lethal effect in E.coli". Paper presented in MICRO´2003, 2003. Pimentel, Madalena; Rodrigues, Lénia; Vital, João; Garcia, Miguel; Moniz-Pereira, José. "Functional analysis of the lytic system of the mycobacteriophage Ms6 in E.col". Paper presented in 103rd General Meeting of the American Society for Microbiology, 2003. "The gene pin of Mycobacteriophage Ms6 encodes a membrane protein which is involved in a superinfection resistance mechanism". Paper presented in Segundas Jornadas da Sociedade Portuguesa de Ciências Farmacêuticas, 2001. Pimentel, Madalena; Anes, Elsa; Miguel Gacia; Moniz-Pereira, José. "Identification of a transmembranar protein encoded by the Gene pin of Mycobacteriophage Ms6: Role in Superinfection Exclusion". Paper presented in Workshop Molecular Approaches to Tuberculosis, Madrid, 2000. Garcia, Miguel; Pimentel, Madalena; Moniz-Pereira, José. "The Expression of the Mycobacteriophage Ms6 Lytic Functions is Controlled by a Premature Transcription Termination Signal". Paper presented in Tuberculosis 2000, 2000. Pimentel, Madalena; Garcia, Miguel; Anes, Elsa; Moniz-Pereira, José. "The Protein Pin of Mycobacteriophage Ms6 is Involved in a Resistance to Superinfection Mechanism". Paper presented in Tuberculosis 2000, 2000.
Journal article	Cátia Silveiro; Mariana Marques; Francisco Olivença; David Pires; Diana Mortinho; Alexandra Nunes; Madalena Pimentel; Elsa Anes; Maria João Catalão. "CRISPRi-mediated characterization of novel anti-tuberculosis targets: Mycobacterial peptidoglycan modifications promote beta-lactam resistance and intracellular survival". Frontiers in Cellular and Infection Microbiology 13 (2023): http://dx.doi.org/10.3389/fcimb.2023.1089911. 10.3389/fcimb.2023.1089911 Francisco Olivença; Cláudia Ferreira; Alexandra Nunes; Cátia Silveiro; Madalena Pimentel; João Paulo Gomes; Maria João Catalão. "Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.985871. 10.3389/fmicb.2022.985871 "Chemical Characterization and Bioactivity of Commercial Essential Oils and Hydrolates Obtained from Portuguese Forest Logging and Thinning". Molecules (2022): https://doi.org/10.3390/molecules27113572. 10.3390/molecules27113572 Adriano M. Gigante; Francisco Olivença; Maria João Catalão; Paula Leandro; José Moniz-Pereira; Sérgio R. Filipe; Madalena Pimentel. "The Mycobacteriophage Ms6 LysB N-Terminus Displays Peptidoglycan Binding Affinity". Viruses 13 7 (2021): 1377-1377. https://doi.org/10.3390/v13071377. 10.3390/v13071377 Gigante, Adriano M.; Olivença, Francisco; Catalão, Maria João; Leandro, Paula; Moniz-Pereira, José; Filipe, Sérgio R.; Pimentel, Madalena. "The mycobacteriophage ms6 lysb n-terminus displays peptidoglycan binding affinity". (2021): http://hdl.handle.net/10362/131840. https://doi.org/10.3390/v13071377 André A. Santos; Marta B. Afonso; Ricardo S. Ramiro; David Pires; Madalena Pimentel; Rui E. Castro; Cecília M.P. Rodrigues. "Host miRNA-21 promotes liver dysfunction by targeting small intestinal Lactobacillus in mice". Gut Microbes 12 1 (2020): 1840766-1840766. https://doi.org/10.1080/19490976.2020.1840766. 10.1080/19490976.2020.1840766 Tan, Yong Zi; Zhang, Lei; Rodrigues, José; Zheng, Ruixiang Blake; Giacometti, Sabrina I; Rosário, Ana L; Kloss, Brian; et al. "Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria". Molecular Cell (2020): Accepted Rosa, Catarina; Asada, Masahito; Hakimi, Hassan; Domingos, Ana; Pimentel, Madalena; Antunes, Sandra. "Transient transfection of Babesia ovis using heterologous promoters". Ticks and Tick-borne Diseases 10 6 (2019): 101279. http://dx.doi.org/10.1016/j.ttbdis.2019.101279. Published • 10.1016/j.ttbdis.2019.101279 Catalão, Maria João; Filipe, Sérgio R.; Pimentel, Madalena; Pimentel, Madalena. "Revisiting anti-tuberculosis therapeutic strategies that target the peptidoglycan structure and synthesis". Frontiers in Microbiology (2019): http://www.scopus.com/inward/record.url?scp=85065905919&partnerID=8YFLogxK. https://doi.org/10.3389/fmicb.2019.00190 Pimentel, Madalena. "Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope". Viruses (2018): http://www.mdpi.com/1999-4915/10/8/428. 10.3390/v10080428 Gigante, A.M.; Hampton, C.M.; Dillard, R.S.; Gil, F.; Catalão, M.J.; Moniz-Pereira, J.; Wright, E.R.; Pimentel, M.. "The Ms6 mycolyl-arabinogalactan esterase lysB is essential for an efficient mycobacteriophage-induced lysis". Viruses 9 11 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85034770173&partnerID=MN8TOARS. 10.3390/v9110343 Pereira, L.; Diogo, J.; Mateus, R.; Pimentel, M.; Videira, M.. "Host-directed strategies using lipid nanoparticles to reduce mycobacteria survival". Journal of Nanoparticle Research 17 2 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922352823&partnerID=MN8TOARS. 10.1007/s11051-015-2892-x Proença, D.; Leandro, C.; Garcia, M.; Pimentel, M.; São-José, C.. "EC300: a phage-based, bacteriolysin-like protein with enhanced antibacterial activity against Enterococcus faecalis". Applied Microbiology and Biotechnology 99 12 (2015): 5137-5149. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929948662&partnerID=MN8TOARS. 10.1007/s00253-015-6483-7 Mendes, J.J.; Leandro, C.; Mottola, C.; Barbosa, R.; Silva, F.A.; Oliveira, M.; Vilela, C.L.; et al. "In vitro design of a novel lytic bacteriophage cocktail with therapeutic potential against organisms causing diabetic foot infections". Journal of Medical Microbiology 63 PART 8 (2014): 1055-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905174218&partnerID=MN8TOARS. 10.1099/jmm.0.071753-0 Proença, D.; Velours, C.; Leandro, C.; Garcia, M.; Pimentel, M.; São-Jose´, C.; Proença, Daniela; et al. "A two-component, multimeric endolysin encoded by a single gene". Molecular Microbiology (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84919667310&partnerID=MN8TOARS. 10.1111/mmi.12857 Pimentel, M.. "Genetics of phage lysis". Microbiology Spectrum 2 1 (2014): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958970567&partnerID=MN8TOARS. 10.1128/microbiolspec. MGM2-0017-2013 Mestre, O.; Hurtado-Ortiz, R.; Dos Vultos, T.; Namouchi, A.; Cimino, M.; Pimentel, M.; Neyrolles, O.; Gicquel, B.. "High Throughput Phenotypic Selection of Mycobacterium tuberculosis Mutants with Impaired Resistance to Reactive Oxygen Species Identifies Genes Important for Intracellular Growth". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872193109&partnerID=MN8TOARS. 10.1371/journal.pone.0053486 Mahapatra, S.; Piechota, C.; Gil, F.; Ma, Y.; Huang, H.; Scherman, M.S.; Jones, V.; et al. "Mycobacteriophage Ms6 LysA: A Peptidoglycan Amidase and a Useful Analytical Tool". Applied and Environmental Microbiology 79 3 (2013): 768-773. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873849826&partnerID=MN8TOARS. 10.1128/AEM.02263-12 Catalão, M.J.; Gil, F.; Moniz-Pereira, J.; São-José, C.; Pimentel, M.. "Diversity in bacterial lysis systems: Bacteriophages Show the way". FEMS Microbiology Reviews 37 4 (2013): 554-571. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878961038&partnerID=MN8TOARS. 10.1111/1574-6976.12006 Proença, D.; Fernandes, S.; Leandro, C.; Silva, F.A.; Santos, S.; Lopes, F.; Mato, R.; et al. "Phage endolysins with broad antimicrobial activity against Enterococcus faecalis clinical strains". Microbial Drug Resistance 18 3 (2012): 322-332. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862018596&partnerID=MN8TOARS. 10.1089/mdr.2012.0024 Fernandes, S.; Proença, D.; Cantante, C.; Silva, F.A.; Leandro, C.; Lourenço, S.; Milheiriço, C.; et al. "Novel chimerical endolysins with broad antimicrobial activity against methicillin-resistant Staphylococcus aureus". Microbial Drug Resistance 18 3 (2012): 333-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862001592&partnerID=MN8TOARS. 10.1089/mdr.2012.0025 Catalão, M.J.; Milho, C.; Gil, F.; Moniz-Pereira, J.; Pimentel, M.. "A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6". PLoS ONE 6 6 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79958281245&partnerID=MN8TOARS. 10.1371/journal.pone.0020515 Catalão, M.J.; Gil, F.; Moniz-Pereira, J.; Pimentel, M.. "The endolysin-binding domain encompasses the N-terminal region of the mycobacteriophage Ms6 Gp1 chaperone". Journal of Bacteriology 193 18 (2011): 5002-5006. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052543330&partnerID=MN8TOARS. 10.1128/JB.00380-11 Catalão, M.J.; Gil, F.; Moniz-Pereira, J.; Pimentel, M.. "Functional analysis of the Holin-Like proteins of mycobacteriophage Ms6". Journal of Bacteriology 193 11 (2011): 2793-2803. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958121285&partnerID=MN8TOARS. 10.1128/JB.01519-10 Gil, F.; Grzegorzewicz, A.E.; Catalão, M.J.; Vital, J.; McNeil, M.R.; Pimentel, M.. "Mycobacteriophage Ms6 LysB specifically targets the outer membrane of Mycobacterium smegmatis". Microbiology 156 5 (2010): 1497-1504. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952375559&partnerID=MN8TOARS. 10.1099/mic.0.032821-0 Catalão, M.J.; Gil, F.; Moniz-Pereira, J.; Pimentel, M.. "The mycobacteriophage Ms6 encodes a chaperone-like protein involved in the endolysin delivery to the peptidoglycan". Molecular Microbiology 77 3 (2010): 672-686. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954850130&partnerID=MN8TOARS. 10.1111/j.1365-2958.2010.07239.x Gil, F.; Catalão, M.J.; Moniz-Pereira, J.; Leandro, P.; McNeil, M.; Pimentel, M.. "The lytic cassette of mycobacteriophage Ms6 encodes an enzyme with lipolytic activity". Microbiology 154 5 (2008): 1364-1371. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249097759&partnerID=MN8TOARS. 10.1099/mic.0.2007/014621-0 Brízio, A.; Conceição, T.; Pimentel, M.; Da Silva, G.; Duarte, A.. "High-level expression of IMP-5 carbapenemase owing to point mutation in the -35 promoter region of class 1 integron among Pseudomonas aeruginosa clinical isolates". 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Intellectual property

Patent

Garcia, Miguel; Pimentel, Madalena; São José, C. 2011. "Enterococcal Phage Peptides And Methods of Use Thereof". Pimentel, Madalena; Garcia, Miguel; São-José, C. 2010. "Antibacterial Phage Peptides And Methods of Use Thereof". Portugal. Withdrawn