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Identification

Personal identification

Full name
Sandra Cristina Cara de Anjo Casimiro

Citation names

  • Casimiro, Sandra

Author identifiers

Ciência ID
0F12-5181-0B22
ORCID iD
0000-0002-6917-4477
Scopus Author Id
14043403400

Email addresses

  • scasimiro@medicina.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Medical Biotechnology Related Ethics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Elementary (A2)
Education
Degree Classification
2007/03/01 - 2013/02/28
Concluded
 Health Sciences (Pós-doutoramento)
Major in Translational Oncobiology
Instituto de Medicina Molecular, Portugal
2008/07/08
Concluded
 Laboratory Animal Science (FELASA C) (Outros)
Universiteit Utrecht, Netherlands
2007
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Biologia Molecular
Universidade de Lisboa, Portugal
"Cloning and Characterization of Hyaloperonospora Parasitica Genes Expressed in the Interaction with Brassica Oleracea" (THESIS/DISSERTATION)
2001/09/17
Concluded
 Agricultura e Horticultura Sustentáveis (Mestrado)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal
"Diversidade Molecular em Peronospora parasitica (Pers. ex fr.) Fr. - Agente Causal do Míldio das Crucíferas" (THESIS/DISSERTATION)
 Aprovado
1996/07/29
Concluded
 Biologia Vegetal Aplicada (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 15/20
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Instituto de Medicina Molecular, Portugal
2013/03/01 - 2018/12/31 Researcher (Research) Instituto de Medicina Molecular, Portugal
2007/03/01 - 2013/02/28 Postdoc (Research) Instituto de Medicina Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2016/04/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2018/10/01 - 2023/12/13 RANK signaling pathway as a mediator of resistance to targeted therapies in breast cancer
SFRH/BD/129619/2017
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2021/11 - 2023/06/30 IFN-mediated immune response in patients with metastatic breast cancer under CDK4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET)
68611059
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Pfizer Portugal
Concluded
2017/10/01 - 2019 Impact of YB-1 expression in breast cancer outcomes under estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-targeted therapies.
NA
Supervisor
Instituto de Medicina Molecular, Portugal
Concluded
2017/12/01 - 2018 Evaluation of the effect of carboxyterminal telopeptide of type I collagen (ICTP) in the breast and prostate cancer cell lines functional properties.
GAPIC 20180012
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2017/01/01 - 2017/12/31 The prognostic role of RANK SNP rs34945627 in breast cancer patients.
FPJ1034
Principal investigator
Instituto de Medicina Molecular, Portugal
 Instituto de Medicina Molecular
Concluded
2017/01/01 - 2017/12/31 Effect of the loss-of-function R450W mutation in the receptor activator of NF¿B (RANK) in the host immune response to breast cancer.
LPCC/Pfizer2016
Supervisor
Instituto de Medicina Molecular, Portugal
 Liga Portuguesa Contra o Cancro
Concluded
2016/12/01 - 2017 Allelic frequency and plasticity of the RANK R450W mutation in germline and breast cancer DNA.
GAPIC 2017023
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2016/12/01 - 2017 Prognostic role of secreted YB-1 in patients with breast cancer.
GAPIC 2017012
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2014/12/12 - 2016/12/11 Peventing bone metastases in ER-positive breast cancer: Identification and clinical validation of putative prognostic biomarkers and therapeutics.
FPJ858
Principal investigator
Instituto de Medicina Molecular, Portugal
 Liga Portuguesa Contra o Cancro
Concluded
2015/04/01 - 2016/03/31 Targeting estrogen receptor (ER)-dependent genes to predict and prevent bone relapse in hormone dependent breast cancer.
FPJ880
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2015/12/31 Molecular markers in multiple myeloma.
FPJ546
Researcher
Instituto de Medicina Molecular, Portugal
 Grupo Hematológico Português
Concluded
2013/12/01 - 2015 Luminal-type breast cancer: genetic variability of RANK gene locus and prognostic value of RANK-positive lymphatic nodes.
GAPIC 2013
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2008/01/01 - 2015 Effects of chemotherapy and radiotherapy in rectal cancer: significance of different cellular outcomes in tumour behavior.
SFRH/BD/45219/2008
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/06/01 - 2013/06/30 Mechanisms of invasion and progression of cancer in bone: Role of matrix metalloproteinases.
SFRH/BPD/34801/2007
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/06/01 - 2011/04/30 Mechanisms of invasion and progression of cancer in bone: Molecular profiling of matrix and adhesion-related molecules in metastatic disease.
FPJ364
Principal investigator
Instituto de Medicina Molecular, Portugal
 Liga Portuguesa Contra o Cancro
Concluded
2010/12/01 - 2011 Via de sinalização RANK-RANKL na doença metastática óssea do cancro da mama: Transactivação de receptores e oportunidades terapêuticas.
GAPIC 2010
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2009/12/01 - 2010 Efeito da via de sinalização RANK-RANKL na expressão génica de MMP1, MMP9, OPG e PTHrP em linhas celulares de cancro da mama e da próstata.
GAPIC 2009
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2008/12/01 - 2009 Efeito da via de sinalização RANK-RANKL na expressão génica de MMP1 e capacidade invasiva de linhas celulares de cancro da mama e da próstata.
GAPIC 2008
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded
2007/12/01 - 2008 Caracterização bioquímica da matriz extracelular do tumor primário, metástase e estroma tumoral.
GAPIC 2007
Supervisor
Instituto de Medicina Molecular, Portugal
 Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina
Concluded

Contract

Designation Funders
2017/01/01 - Current Oncodynamics.
FPJ900
Researcher
Instituto de Medicina Molecular, Portugal
 Novartis Farma SA

Merck SA

Servier Portugal Especialidades Farmacêuticas Lda

Roche Farmaceutica Quimica Lda

MSD
Ongoing
2016/06/01 - Current PERSEIDS - Personalizing cancer therapy through integrated modeling and decision.
PTDC/EMS-SIS/0642/2014
Consultant
Instituto de Medicina Molecular, Portugal

Instituto de Engenharia Mecânica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/01/17 - 2025/01/16 Multifunctional nano-immunotherapy for melanoma brain metastases treatment
PTDC/BTM-SAL/4350/2021
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 A molecular and nano approach to target the RANK-TRAF6 interface for bone metastases treatment
PTDC/QUI-OUT/3854/2021
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Centro de Ciências e Tecnologias Nucleares, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2021/08/31 Physiopathology and clinical implications of the RANK c.1386C>T (R450W) mutation in breast cancer patients
PTDC/MED-ONC/28636/2017
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Pathological nerve sprouting in bone metastases: OSTEOCLASTS, what are you doing
PTDC/MED-PAT/30158/2017
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/04/01 - 2018/03/31 Analysis of RANK protein expression in Cohort 2 using immunohistochemistry (IHC) in 70 matched primary breast cancer tumors and distant metastasis.
FPJ885
Researcher
Instituto de Medicina Molecular, Portugal
 Amgen Inc
Concluded
2012/04/01 - 2018 Global Cancer Genomic Consortium.
FPJ632
Researcher
Instituto de Medicina Molecular, Portugal
Ongoing
2013/11/15 - 2016/12/30 Molecular Characterization of Breast Cancers.
FPJ757
Principal investigator
Instituto de Medicina Molecular, Portugal
 Novartis Farma SA
Concluded
2013/06/01 - 2016/11/30 Molecular and Nano Tools for Cancer Theranostics
EXCL/QEQ-MED/0233/2012
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/05/04 - 2015/12/31 Senescence in rectal cancer.
FPJ559
Supervisor
Instituto de Medicina Molecular, Portugal
 Merck SA
Concluded
2011/01/01 - 2015/12/31 Long Term Bisphosphonates.
FPJ575
Researcher
Instituto de Medicina Molecular, Portugal
 Novartis Farma SA
Concluded
2013/12/02 - 2015/12/01 c-Met, p-c-Met, and HGF IHC in Bone Metastases.
FPJ777
Principal investigator
Instituto de Medicina Molecular, Portugal
 Merck SA
Concluded
2014/04/01 - 2015/09/30 CancerSys - Multiscale modeling for personalized therapy of bone metastasis
EXPL/EMS-SIS/1954/2013
Instituto de Engenharia Mecânica, Portugal

Instituto de Engenharia Mecânica, Portugal

Instituto de Telecomunicações, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/11/01 - 2014/04/30 Oncobiology: developing educational tools for a new generation of physician-scientists
HMSP-PCM/0007/2010
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/02/28 Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents
PTDC/QUI-QUI/115712/2009
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/09/29 Prognostic Signatures in Colorectal Cancer (PSCC)
PIC/IC/82821/2007
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/11/07 - 2011/12/06 Analysis of RANK protein expression in bone metastasis.
FPJ168
Researcher
Instituto de Medicina Molecular, Portugal
 Amgen Europe GmbH
Concluded
2008/01/01 - 2008/12/31 Molecular Markers of Bone Metastases.
FPJ129
Researcher
Instituto de Medicina Molecular, Portugal
 Novartis Farma SA
Concluded
2005/05/02 - 2007/12/31 PEPAGENE - Resistance to brassica downy mildew via an avirulence gene expression approach
POCI/AGR/56755/2004
PhD Student Fellow
Universidade de Lisboa Instituto Superior de Agronomia, Portugal

Universidade de Lisboa Instituto Superior de Agronomia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002/10/01 - 2006/09/30 IDENTIFICAÇÃO E CARACTERIZAÇÃO DOS GENES DE AVIRULÊNCIA E VIRULÊNCIA EM PERONOSPORA PARASÍTICA
SFRH/BD/8975/2002
PhD Student Fellow
Universidade de Lisboa Instituto Superior de Agronomia, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Raquel Brás; Isabel Fernandes; Casimiro, Sandra; Luis Costa. "Medical Therapy of Giant Cell Tumors of the Bone". IntechOpen, 2021.
    Accepted
  2. Casimiro, Sandra. "Host-pathogen interactions: Brassica downy mildew, a successful oomycete.". In Recent Research Developments in Plant Science, 1-40. BENTHAM SCIENCE PUBLISHERS, 2007.
    Published
Conference abstract
  1. Luis Costa; Patrícia Corredeira; Patrícia Alves; Marília Antunes; Sara Dâmaso;; Soraia Lobo-Martins; Patrícia Semedo; Helena Pais; Ângela Rodrigues; Filipe Moreira;; Cristiana Pinheiro; André Mansinho; António Quintela; Pedro Filipe; Leonor Ribeiro;; Rita Teixeira de Sousa; Conceição Pinto; Teresa Pacheco;; Casimiro, Sandra; Marta Martins; Ana Cavaco; Gisela S. Gordino; Julie C. Ribot; Karine Serre; Bruno Silva-Santos.. "Prospective analysis of immune cell populations in peripheral blood of Metastatic Breast Cancer Patients reveals selective T cell subset biases". Paper presented in 2021 ASCO Annual Meeting, 2021.
    Submitted
Conference poster
  1. "RANKL-blockade is effective against RANK-mediated resistance to chemo and hormone therapy in Luminal breast cancer". Paper presented in 7th PORTO CANCER MEETING Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  2. "RANK signalling pathway: a new driver of resistance to CDK4/6 inhibitors in breast cancer". Paper presented in XIV CAML. IV NeurULisboa Virtual meeting, 2021.
  3. Soraia Lobo-Martins, Patrícia Corredeira, Patrícia Borges Alves, Marília Antunes, Ângela Rodrigues, António Quintela,; Pedro Filipe, Leonor Ribeiro, Rita Teixeira de Sousa, Conceição Pinto, Catarina Abreu, Gisela Gordino, Julie Ribot,; Karine Serre, Marta Martins, Ana Cavaco,; Casimiro, Sandra; Bruno Silva-Santos and Luís Costa. "Immune cell populations in peripheral blood of metastatic breast cancer patients under CDK4/6 inhibitors". Paper presented in CTRC-AACR San Antonio Breast Cancer Symposium, 2020.
  4. Inês Gomes; Luis Costa; Casimiro, Sandra. "Receptor Activator of NFkB (RANK) pathway is associated with resistance to endocrine therapy in Luminal A breast cancer". Paper presented in Webinar "Cancer Biology: From Basic to Translational Research”, Liga Portuguesa Contra o Cancro, 2020.
  5. S. Marques, P. Pereira, J. Pimentel,; Casimiro, Sandra; Luis Costa. "Cancer-associated fibroblast in breast cancer brain metastases". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, 2020.
  6. Inês Gomes, Bernardo P. de Almeida, Sara Dâmaso, André Mansinho, Raquel Cruz-Duarte, Guilherme Vilhais,; Patrícia Alves, Nuno L. Barbosa-Morais, Luis Costa; Casimiro, Sandra. "RANK ligand (RANKL)-rich microenvironment drives resistance to hormone therapy in ER+HER2- breast cancer". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, 2020.
  7. Guilherme Vilhais, Inês Gomes, Bernardo P. de Almeida, L. Barbosa-Morais, Luís Costa,; Casimiro, Sandra. "Tackling the mystery of the small xenografts: RANK-pathway activation in RANK overexpressing breast cancer xenografts in an immune deficient mouse host.". Paper presented in In4Med, 2020.
  8. L Liu, C Garbutt, M Golkaram, S Kaplan, M Martins,; Casimiro, Sandra; A Mansinho, D Macedo, C Alvim, A L Costa,; A Fernandes, C Ferreira, F Aldeia, A Quintela, L Costa, A So, S Zhang, T Pawlowski.. "Microsatellite instability testing and lynch syndrome screening for colorectal cancer patients through tumour sequencing". Paper presented in ESMO, 2019.
  9. Corredeira P, Alves P, Gordino G, Pereira S, Ribot J, Andrade P, Bruçó L, Pinheiro C,; Casimiro, Sandra; Martins M, Mansinho A, Ribeiro L, Fernandes I, Vendrell I, Pinto C, Dionísio MR, Sousa R, Silva-Santos B , Costa L.. "T cell profiling in metastatic breast cancer reveals a subtype independent immunosuppressive state". Paper presented in ASEICA-ASPIC International Meeting, 2019.
  10. Casimiro, Sandra; Inês Gomes, Bernardo Almeida, Patrícia Alves, Pedro Félix, Guilherme Vilhais, André Mansinho,; Maria Rita Dionísio, Nuno L. Barbosa-Morais, Luis Costa.. "Elevated RANK expression in estrogen receptor-positive breast cancer is a driver of stemness". Paper presented in ESMO BC 2019, 2019.
  11. Ferreira, Arlindo R.; Casimiro, Sandra; Ali, S.; Leitzel, K.; Lipton, A.; Costa, Luis. "Impact of the metastatic compartment on bone biomarkers and bone outcomes in patients (pts) with breast cancer (BC) and bone metastases (BM) in trial NCT00321464 of denosumab vs. zoledronic acid.". Paper presented in San Antonio Breast Cancer Symposium 2018, 2018.
  12. Carrasquinha, Eunice; Lopes, Marta Belchior; Veríssimo, André; Casimiro, Sandra; Beerenwinkel, N; Vinga, Susana. "Ensemble outlier detection in cancer gene expression data.". Paper presented in 17th European Conference on Computational Biology, 2018.
  13. Lopes, Marta Belchior; Veríssimo, André; Casimiro, Sandra; Carrasquinha, Eunice; Vinga, Susana. "Network-based penalized logistic regression for the identification of common gene signatures in breast and prostate cancers.". Paper presented in Data Science, Statistics and Visualisation (DSSV 2018), 2018.
  14. Casimiro, Sandra; Inês Gomes; Alnas, G; Pedro Félix; Ferreira, Arlindo R.; Kyte, JA; Kristensen, V; Naume, B; Costa, Luis. "Normal minor allele frequency of the R450W RANK mutation in breast cancer patients: a large cohort retrospective study.". Paper presented in 3rd ASPIC International Congress, 2018.
  15. Corredeira, Patrícia; Martins, Patrícia; Andrade, Pedro; Mansinho, André; Ferreira, Arlindo R.; Casimiro, Sandra; Ribot, Julie; et al. "Oncodynamics Liquid Biobanking: A holistic perspective towards predictive medicine in metastatic cancer". Paper presented in III Simposio Biopsia Liquida 2018, 2017.
  16. Casimiro, Sandra; Bettencourt, Maria José Palma; Fernandes, A.; Pacheco, Teresa R.; Maia-Matos, M; Costa, Ana Lúcia; Abreu, Catarina; et al. "Phosphorylated YB-1 (Y-box binding protein 1) as a biomarker of poor prognosis in patients with breast cancer.". Paper presented in 24th Biennial Congress of the European Association for Cancer Research, 2016.
  17. Casimiro, Sandra; Ferreira, Arlindo R.; Alho, Irina; Melo, Marta; Brás, Raquel; Costa, Ana Lúcia; Mansinho, André; et al. "The prognostic role of RANK single nucleotide polymorphisms in breast cancer patients with bone metastases.". Paper presented in CTRC-AACR San Antonio Breast Cancer Symposium, 2015.
  18. Fernandes, C.; Monteiro, S.; Mendes, P.; Gano, L.; Marques, F.; Casimiro, Sandra; Costa, L.; Santos, I.. "Novel 99mTc(I)-labeled bone-seeking molecules for bone imaging.". Paper presented in CIBD 2014, 2013.
  19. Fernandes, C.; Monteiro, S.; Mendes, P.; Gano, L.; Marques, F.; Casimiro, Sandra; Costa, L.; Santos, I.. "Bisphosphonate-Containing M(CO)3-Complexes (M = 9mTc/Re) as Bone-Seeking Agents.". Paper presented in The 3rd Global Cancer Genomics Consortium Symposium, 2013.
  20. Pires, Ricardo; Casimiro, Sandra; Fernandes, Afonso; Tato-Costa, Joana; Alho, Irina; Vieira, E; Ferreira, C; et al. "Colorectal cancer biobanking for genomic and transcriptomic profiling of disease progression.". Paper presented in The 3rd Global Cancer Genomics Consortium Symposium, 2013.
  21. Tato-Costa, Joana; Casimiro, Sandra; Costa, Luis. "Cellular senescence in rectal cancer: friend or foe?.". Paper presented in The 3rd Global Cancer Genomics Consortium Symposium, 2013.
  22. Shan, N.; Alho, Irina; Matias, M.; Faria, M.; Casimiro, Sandra; Ferreira, Arlindo R.; Leitzel, K.; et al. "N-telopeptide of type I collagen (NTX) dynamics over one year of determinations in patients with breast cancer (BC) with bone metastases (BM): Predictive factors of outcome.". Paper presented in ASCO 2013, 2013.
  23. Casimiro, Sandra; Margarida Coelho; Alho, Irina; Pires, Ricardo; Costa, Luis. "In vitro evaluation of the antitumoral and anti-osteoclastogenic effect of combined therapy with zoledronic acid and saracatinib in breast cancer.". Paper presented in XII International Conference on Cancer-Induced Bone Disease, 2012.
  24. Ribeiro, J.; Vaz-Luis, I; Correia, Lurdes; Casimiro, Sandra; Fernandes, Afonso; Quintela, António; Mestan, J; Ramos, M.; Costa, Luis. "Correlation between aromatase expression in metastatic and primary breast cancer.". Paper presented in CTRC-AACR San Antonio Breast Cancer Symposium, 2011.
  25. Costa, Luis; Alho, Irina; Semedo, Mónica; Vaz-Luis, I; Quintela, António; Casimiro, Sandra; Ribeiro, J.; et al. "Retrospective Analysis of Long-term Bisphosphonate Therapy for Patients With Bone Metastases—Bone Marker Profiles and Safety.". Paper presented in XI International Conference on Cancer-Induced Bone Disease, 2011.
  26. Costa, Luis; Vaz-Luis, I; Alho, Irina; Fernandes, Afonso; Casimiro, Sandra; Lee, BH; Gangoli, EA; Motwani, M; Wang, VM. "Expression of Matrix Metalloproteinase 1 (MMP1), Dickkopf-1 (Dkk1) and Macrophage Colony Stimulating Factor Receptor 1 (MCSFR1) in bone metastatic tissue (BMT) and in serum of patients with bone metastases (BM) from different solid tumors.". Paper presented in 35th ESMO Congress, 2010.
  27. Pacheco, Teresa R.; Costa, A.; Santos, A.C.; Oliveira, A.G.; Casimiro, Sandra; Quintela, António; Fernandes, Afonso; Costa, Luis. "mTOR Activation in Advanced Neuroendocrine Tumors in Treatment with Somastotatin Analogues – a Single Center Study.". Paper presented in 35th ESMO Congress, 2010.
  28. Costa, Luis; Vaz-Luis, I; Alho, Irina; Fernandes, Afonso; Casimiro, Sandra; Lee, BH; Gangoli, EA; Motwani, M; Wang, VM. "Expression of Matrix Metalloproteinase 1 (MMP1) and Dickkopf-1 (Dkk1) in bone metastatic tissue (BMT) and in serum of patients with bone metastases (BM) from different solid tumors.". Paper presented in X International Conference on Cancer-Induced Bone Disease, 2010.
  29. Casimiro, Sandra; Pires, Ricardo; Pacheco, Teresa R.; Tato-Costa, Joana; Alho, Irina; Vaz-Luis, I; Ribeiro, J.; et al. "Type I collagen telopeptides NTx and ICTP stimulate breast cancer cells MDA-231-BO2 proliferation in vitro.". Paper presented in VIII International Meeting on Cancer Induced Bone Diseases, 2009.
  30. Costa, Luis; Alho, Irina; Casimiro, Sandra; Oliveira, António G.; Ribeiro, J.; Vaz-Luis, I; Fernandes, Afonso; et al. "Serum type I collagen C-Telopeptide (ICTP) predicts bone resorption level (NTX) normalization, skeletal-related events (SREs) and overall survival (OS) in breast cancer (BC) patients treated with bisphosphonates (BP)". Paper presented in VIII International Meeting on Cancer Induced Bone Diseases, 2009.
  31. Rodrigues, TA; Casimiro, Sandra; Gasparinho, G; Crujo, C; Maia-Matos, M; Ruivo, J; Fernandes, Afonso; Quintela, António; Costa, Luis. "Involvement of chemokine receptors CXR4, CCR7, CCR6, and CXCR5 in colorectal cancer metastasis.". Paper presented in 2009 Gastrointestinal Cancers Symposium, 2009.
  32. Casimiro, Sandra; Alho, Irina; Fernandes, Afonso; Lipton, A.; Guise, T.A.; Costa, Luis. "RANKL plays a role in migration and invasion of the bone-seeking cell line MDA-MB-231-BO2 and regulates MMP1 and MMP9 expression.". Paper presented in VII International Meeting on Cancer Induced Bone Diseases, 2008.
  33. Costa, Luis; Alho, Irina; Casimiro, Sandra; Oliveira, A.G.; Bicho, M; Carvalho, R; Fernandes, Afonso; et al. "Markers of Bone Turnover (ICTP, NTX) and Serum Matrix Metalloproteinase 1 (MMP1) as Prognostic Markers in Breast Cancer Patients with Bone Metastases (BM) Treated with Bisphosphonates (BP).". Paper presented in 44th ASCO Annual Meeting, 2008.
  34. Costa, Luis; Alho, Irina; Casimiro, Sandra; Oliveira, A.G.; Bicho, M; Carvalho, R; Fernandes, Afonso; et al. "Markers of Bone Turnover (ICTP, NTX) and Serum Matrix Metalloproteinase 1 (MMP1) as Prognostic Markers in Breast Cancer Patients with Bone Metastases (BM) Treated with Bisphosphonates (BP).". Paper presented in Skeletal Complications of Malignancy Symposium, 2007.
  35. Casimiro, Sandra; Tenreiro, R.; Monteiro, A.A.. "Transcriptomics of the host-pathogen interaction in crucifer downy mildew: a road to new genes of Hyaloperonospora parasitica.". Paper presented in Oomycete Molecular Genetics Network Spring 2006, 2006.
  36. Casimiro, Sandra; Zé-Zé, L.; Tenreiro, R.; Monteiro, A.A.. "DD-PCR based analysis of the pathosystem Brassica oleracea – Peronospora parasitica reveals potential phytopathogenicity related cDNA genes.". Paper presented in MicroBiotech’2005, 2005.
  37. Casimiro, Sandra; Zé-Zé, L.; Tenreiro, R.; Monteiro, A.A.. "Analysis of pathogen (a)virulence factors in the Brassica oleracea-Peronospora parasitica interaction transcriptome.". Paper presented in 7th Conference of the European Society of Plant Pathology, 2004.
  38. Casimiro, Sandra; Zé-Zé, L.; Tenreiro, R.; Monteiro, A.A.. "Míldio das Crucíferas (In)Visível)? Diagnóstico molecular por multiplex PCR.". Paper presented in 4º Congresso da Sociedade Portuguesa de Fitopatologia, 2004.
  39. Casimiro, Sandra; Zé-Zé, L.; Tenreiro, R.; Monteiro, A.A.. "Mining for pathogen (a)virulence factors: DD-PCR transcriptome analysis of the pathosystem Brassica oleracea-Peronospora parasitica.". Paper presented in Micro2003, 2003.
  40. Casimiro, Sandra; Tenreiro, R.; Monteiro, A.A.. "Pathogenesis-related cDNA genes from Brassica oleracea seedlings infected by Peronospora parasitica.". Paper presented in 8th International Congress of Phytopathology, 2003.
  41. Casimiro, Sandra; Tenreiro, R.; Monteiro, A.A.. "Molecular diversity and host-pathogen co-evolution in crucifer downy mildew.". Paper presented in 8th International Congress of Phytopathology, 2003.
  42. Casimiro, Sandra; Tenreiro, R.; Monteiro, A.A.. "Searching for Avr genes in the pathosystem Brassica oleracea-Peronospora parasitica. A Differential Display approach.". Paper presented in Molecular Basis of Fungal-Plant Interactions Workshop, 2003.
  43. Casimiro, Sandra; Moura, M.; Tenreiro, R.; Monteiro, A.A.. "Detecção Molecular por ITS-ARDRA de Míldio das Crucíferas “Camuflado” em Hospedeiros Resistentes.". Paper presented in Micro2001, 2001.
  44. Casimiro, Sandra; Moura, M.; Tenreiro, R.; Monteiro, A.A.. "Molecular Identification and Genomic Diversity of Peronospora parasitica in Crucifer Downy Mildew.". Paper presented in 101st General Meeting of the American Society for Microbiology, 2001.
Journal article
  1. Inês Gomes; Catarina Abreu; Luis Costa; Sandra Casimiro. "The Evolving Pathways of the Efficacy of and Resistance to CDK4/6 Inhibitors in Breast Cancer". Cancers (2023): https://doi.org/10.3390/cancers15194835.
    10.3390/cancers15194835
  2. Tiago Barroso; CECILIA MELO-ALVIM; Leonor Abreu Ribeiro; Sandra Casimiro; Luis Costa. "Targeting Inhibitor of Apoptosis Proteins to Overcome Chemotherapy Resistance—A Marriage between Targeted Therapy and Cytotoxic Chemotherapy". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/17/13385.
    10.3390/ijms241713385
  3. Inês Gomes; Lina M. Gallego-Paez; Maria Jiménez; Patricia G. Santamaria; André Mansinho; Rita Sousa; Catarina Abreu; et al. "Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer". Cell Reports Medicine (2023): https://doi.org/10.1016/j.xcrm.2023.101120.
    10.1016/j.xcrm.2023.101120
  4. Daniel Sobral; Marta Martins; Shannon Kaplan; Mahdi Golkaram; Michael Salmans; Nafeesa Khan; Raakhee Vijayaraghavan; et al. "Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development". Communications Biology (2022): https://doi.org/10.1038/s42003-022-03884-x.
    10.1038/s42003-022-03884-x
  5. Inês Soares de Pinho; Catarina Abreu; Inês Gomes; Sandra Casimiro; Teresa Raquel Pacheco; Rita Teixeira de Sousa; Luís Costa. "Exploring new pathways in endocrine-resistant breast cancer". Exploration of Targeted Anti-tumor Therapy (2022): https://doi.org/10.37349/etat.2022.00086.
    10.37349/etat.2022.00086
  6. Joana Mota; Sandra Casimiro; João Fernandes; Renata M. Hartmann; Elizângela Schemitt; Jaqueline Picada; Luís Costa; et al. "Lupin Protein Concentrate as a Novel Functional Food Additive That Can Reduce Colitis-Induced Inflammation and Oxidative Stress". Nutrients (2022): https://doi.org/10.3390/nu14102102.
    10.3390/nu14102102
  7. Joaquim Soares do Brito; Raquel Lopes-Brás; André Abrunhosa-Branquinho; Isabel Fernandes; Inês Gomes; Sandra Casimiro; Luís Costa. "A Tailored Approach for Appendicular Impending and Pathologic Fractures in Solid Cancer Metastases". Cancers 14 4 (2022): 893-893. https://doi.org/10.3390/cancers14040893.
    10.3390/cancers14040893
  8. Sandra Casimiro; Guilherme Vilhais; Inês Gomes; Luis Costa. "The Roadmap of RANKL/RANK Pathway in Cancer". Cells (2021): https://doi.org/10.3390/cells10081978.
    10.3390/cells10081978
  9. Golkaram, Mahdi; Salmans, Michael L.; Kaplan, Shannon; Vijayaraghavan, Raakhee; Martins, Marta; Khan, Nafeesa; Garbutt, Cassandra; et al. "HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome". npj Genomic Medicine 6 1 (2021): http://dx.doi.org/10.1038/s41525-021-00177-w.
    Published • 10.1038/s41525-021-00177-w
  10. Joaquim Soares do Brito; Raquel Lopes-Brás; André Abrunhosa-Branquinho; Isabel Fernandes; Inês Gomes;; Casimiro, Sandra; Luis Costa. "Risk of pathologic fractures: Bench insights and clinical evidence". Journal of Cancer Metastasis and Treatment (2021):
    Under revision
  11. Joana Pinheiro Neto; Irina Alho; Luís Costa;; Casimiro, Sandra; Duarte Valério; Susana Vinga. "Dynamic modeling of bone remodeling, osteolytic metastasis and PK/PD therapy: introducing variable order derivatives as a simplification technique". Journal of Mathematical Biology (2021):
    Under revision
  12. Rita Silva Paiva; Inês Gomes; Sandra Casimiro; Isabel Fernandes; Luís Costa. "c-Met expression in renal cell carcinoma with bone metastases". Journal of Bone Oncology 25 (2020): 100315-100315. https://doi.org/10.1016/j.jbo.2020.100315.
    10.1016/j.jbo.2020.100315
  13. Soraia Lobo-Martins; Arlindo R. Ferreira; André Mansinho; Sandra Casimiro; Kim Leitzel; Suhail Ali; Allan Lipton; Luís Costa. "Impact of Extraskeletal Metastases on Skeletal-Related Events in Metastatic Castration-Resistant Prostate Cancer with Bone Metastases". Cancers (2020): https://doi.org/10.3390/cancers12082034.
    10.3390/cancers12082034
  14. Martins Cavaco, Ana C.; Dâmaso, Sara; Casimiro, Sandra; Costa, Luís. "Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis". Cancer and Metastasis Reviews 39 3 (2020): 603-623. http://dx.doi.org/10.1007/s10555-020-09888-5.
    Published • 10.1007/s10555-020-09888-5
  15. Inês Gomes; Bernardo de Almeida; Sara Dâmaso; André Mansinho; Inês Correia; Sara Henriques; Raquel Cruz-Duarte; et al. "Expression of Receptor Activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer". Oncotarget (2020):
    In press
  16. Querido, Sara; Fernandes, Isabel; Weigert, André; Casimiro, Sandra; Albuquerque, Catarina; Ramos, Sância; Adragão, Teresa; et al. "High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: The first evidence of JC virus as a potential oncovirus in bladder cancer". American Journal of Transplantation (2019): http://dx.doi.org/10.1111/ajt.15663.
    10.1111/ajt.15663
  17. Lopes, Marta B.; Casimiro, Sandra; Vinga, Susana. "Twiner: correlation-based regularization for identifying common cancer gene signatures". BMC Bioinformatics 20 1 (2019): http://dx.doi.org/10.1186/s12859-019-2937-8.
    10.1186/s12859-019-2937-8
  18. Mansinho, André; Ferreira, Arlindo R.; Casimiro, Sandra; Alho, Irina; Vendrell, Inês; Costa, Ana Lúcia; Sousa, Rita; et al. "Levels of Circulating Fibroblast Growth Factor 23 (FGF23) and Prognosis in Cancer Patients with Bone Metastases". International Journal of Molecular Sciences 20 3 (2019): 695. http://dx.doi.org/10.3390/ijms20030695.
    10.3390/ijms20030695
  19. Dionísio, Maria Rita; Mansinho, André; Abreu, Catarina; Cavaco-Silva, Joana; Casimiro, Sandra; Costa, Luís. "Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer-induced bone loss". British Journal of Clinical Pharmacology (2019): http://dx.doi.org/10.1111/bcp.13852.
    10.1111/bcp.13852
  20. Segaert, Pieter; Lopes, Marta B; Casimiro, Sandra; Vinga, Susana; Rousseeuw, Peter J. "Robust identification of target genes and outliers in triple-negative breast cancer data". Statistical Methods in Medical Research (2018): 096228021879472. http://dx.doi.org/10.1177/0962280218794722.
    10.1177/0962280218794722
  21. Lopes, Marta B.; Veríssimo, André; Carrasquinha, Eunice; Casimiro, Sandra; Beerenwinkel, Niko; Vinga, Susana. "Ensemble outlier detection and gene selection in triple-negative breast cancer data". BMC Bioinformatics 19 1 (2018): http://dx.doi.org/10.1186/s12859-018-2149-7.
    10.1186/s12859-018-2149-7
  22. Ferreira, A.R.; Bettencourt, M.; Alho, I.; Costa, A.L.; Sousa, A.R.; Mansinho, A.; Abreu, C.; et al. "Serum YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases". Journal of Bone Oncology 6 (2017): 16-21. http://dx.doi.org/10.1016/j.jbo.2017.01.002.
    10.1016/j.jbo.2017.01.002
  23. Pulido, Catarina; Vendrell, Inês ; Ferreira, Arlindo R ; Casimiro, Sandra; Mansinho, André; Alho, Irina; Costa, Luís. "Bone metastasis risk factors in breast cancer". ecancermedicalscience 11 (2017): http://dx.doi.org/10.3332/ecancer.2017.715.
    10.3332/ecancer.2017.715
  24. Ribeiro, Elisabete; Alho, Irina; Marques, Fernanda; Gano, Lurdes; Correia, Isabel; Correia, João D.G.; Casimiro, Sandra; et al. "Radiolabeled block copolymer micelles for image-guided drug delivery". International Journal of Pharmaceutics 515 1-2 (2016): 692-701. http://dx.doi.org/10.1016/j.ijpharm.2016.11.004.
    10.1016/j.ijpharm.2016.11.004
  25. Ferreira, A. R.; Alho, I.; Shan, N.; Matias, M.; Faria, M.; Casimiro, S.; Leitzel, K.; et al. "N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases". The Oncologist 21 12 (2016): 1418-1426. http://dx.doi.org/10.1634/theoncologist.2015-0527.
    10.1634/theoncologist.2015-0527
  26. Casimiro, Sandra. "Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?". International Journal of Molecular Sciences (2016): http://www.mdpi.com/1422-0067/17/9/1415.
    10.3390/ijms17091415
  27. Tato-Costa, Joana; Casimiro, Sandra; Pacheco, Teresa; Pires, Ricardo; Fernandes, Afonso; Alho, Irina; Pereira, Pedro; et al. "Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer". Clinical Colorectal Cancer 15 2 (2016): 170-178.e3. http://dx.doi.org/10.1016/j.clcc.2015.09.003.
    10.1016/j.clcc.2015.09.003
  28. Ferreira, Arlindo; Alho, Irina; Vendrell, Inês; Melo, Marta; Brás, Raquel; Costa, Ana Lúcia; Sousa, Ana Rita; et al. "The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases". Oncotarget 7 27 (2016): http://dx.doi.org/10.18632/oncotarget.9356.
    10.18632/oncotarget.9356
  29. Body JJ; Casimiro S; Costa L. "Targeting bone metastases in prostate cancer: improving clinical outcome.". (2015): http://europepmc.org/abstract/med/26119830.
    10.1038/nrurol.2015.90
  30. Ferreira A; Alho I; Casimiro S; Costa L. "Bone remodeling markers and bone metastases: From cancer research to clinical implications.". (2015): http://europepmc.org/abstract/med/25908969.
    10.1038/bonekey.2015.35
  31. Casimiro S; Fernandes A; Oliveira AG; Franco M; Pires R; Peres M; Matias M; et al. "Metadherin expression and lung relapse in patients with colorectal carcinoma.". (2014): http://europepmc.org/abstract/med/24946951.
    10.1007/s10585-014-9659-0
  32. Costa L; Casimiro S; Gupta S; Knapp S; Pillai MR; Toi M; Badwe R; Carmo-Fonseca M; Kumar R. "The global cancer genomics consortium's third annual symposium: from oncogenomics to cancer care.". (2014): http://europepmc.org/abstract/PMC/PMC4091529.
  33. Fernandes, C.; Monteiro, S.; Mendes, P.; Gano, L.; Marques, F.; Casimiro, S.; Costa, L.; Correia, J.D.G.; Santos, I.. "Biological assessment of novel bisphosphonate-containing 99mTc/Re-organometallic complexes". Journal of Organometallic Chemistry (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886959842&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.10.038
  34. Casimiro, S.; Alho, I.; Bettencourt, M.; Pires, R.; Lipton, A.; Costa, L.. "RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells". Journal of Bone Oncology (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880799147&partnerID=MN8TOARS.
    10.1016/j.jbo.2013.07.001
  35. Pakala, S.B.; Rayala, S.K.; Wang, R.-A.; Ohshiro, K.; Mudvari, P.; Reddy, S.D.N.; Zheng, Y.; et al. "MTA1 promotes STAT3 transcription and pulmonary metastasis in breast cancer". Cancer Research 73 12 (2013): 3761-3770. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879076893&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-12-3998
  36. Casimiro, S.; Mohammad, K.S.; Pires, R.; Tato-Costa, J.; Alho, I.; Teixeira, R.; Carvalho, A.; et al. "RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro". PLoS ONE 8 5 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84877807530&partnerID=MN8TOARS.
    10.1371/journal.pone.0063153
  37. Horvath A; Pakala SB; Mudvari P; Reddy SD; Ohshiro K; Casimiro S; Pires R; et al. "Novel insights into breast cancer genetic variance through RNA sequencing.". (2013): http://europepmc.org/abstract/med/23884293.
    10.1038/srep02256
  38. Fernandes, I.; Pacheco, T.R.; Costa, A.; Santos, A.C.; Fernandes, A.R.; Santos, M.; Oliveira, A.G.; et al. "Prognostic significance of AKT/mTOR signaling in advanced neuroendocrine tumors treated with somatostatin analogs". OncoTargets and Therapy 5 (2012): 409-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873906537&partnerID=MN8TOARS.
    10.2147/OTT.S36330
  39. Casimiro, S.; Luis, I.; Fernandes, A.; Pires, R.; Pinto, A.; Gouveia, A.G.; Francisco, A.F.; et al. "Analysis of a bone metastasis gene expression signature in patients with bone metastasis from solid tumors". Clinical and Experimental Metastasis 29 2 (2012): 155-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857167793&partnerID=MN8TOARS.
    10.1007/s10585-011-9438-0
  40. Luís, I.V.; Casimiro, S.; Ribeiro, J.; Costa, L.. "Zoledronic acid: Its use in the treatment of breast cancer". Clinical Medicine Insights: Therapeutics 2 (2010): 913-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650793004&partnerID=MN8TOARS.
    10.4137/CMT.S2353
  41. Casimiro, S.; Guise, T.A.; Chirgwin, J.. "The critical role of the bone microenvironment in cancer metastases". Molecular and Cellular Endocrinology 310 1-2 (2009): 71-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249206543&partnerID=MN8TOARS.
    10.1016/j.mce.2009.07.004
  42. Vitor, R.F.; Esteves, T.; Marques, F.; Raposinho, P.; Paulo, A.; Rodrigues, S.; Rueff, J.; et al. "99mTc-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells". Cancer Biotherapy and Radiopharmaceuticals 24 5 (2009): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449113426&partnerID=MN8TOARS.
    10.1089/cbr.2009.0647
  43. Casimiro, S.; Tenreiro, R.; Monteiro, A.A.. "Identification of pathogenesis-related ESTs in the crucifer downy mildew oomycete Hyaloperonospora parasitica by high-throughput differential display analysis of distinct phenotypic interactions with Brassica oleracea". Journal of Microbiological Methods 66 3 (2006): 466-478. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746168643&partnerID=MN8TOARS.
    10.1016/j.mimet.2006.01.015
  44. Casimiro, S.; Moura, M.; Zé-Zé, L.; Tenreiro, R.; Monteiro, A.A.. "Internal transcribed spacer 2 amplicon as a molecular marker for identification of Peronospora parasitica (crucifer downy mildew)". Journal of Applied Microbiology 96 3 (2004): 579-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542299157&partnerID=MN8TOARS.
    10.1111/j.1365-2672.2004.02193.x
Thesis / Dissertation
  1. "Effect of RANK+ breast cancer cells’ secretome in monocytic differentiation". Master, Universidade de Lisboa Faculdade de Medicina, 2022.
  2. "Ikaros and C14ORF143-dependent Cell Competition on Basal Cell Carcinoma". Master, Universidade de Lisboa Faculdade de Medicina, 2021.
  3. "Effect of long-term RANK pathway blockade with OPG-Fc in RANK-overexpressing Luminal breast cancer cells". Master, Universidade de Lisboa Faculdade de Medicina, 2021.
  4. "Tradução independente de cap da proteína humana up-frameshift 1 (UPF1) e cancro". Master, Universidade de Lisboa Faculdade de Medicina, 2021.
  5. "Transcriptomic analysis of cancer cells with winner and loser behaviour". Master, Universidade de Lisboa Faculdade de Medicina, 2021.
  6. "Tackling the mystery of the “small xenografts”: RANK-pathway activation in RANK overexpressing breast cancer xenografts in an immune deficient mouse host". Master, Universidade de Lisboa Faculdade de Medicina, 2021.
  7. Barroso, Mariana Isabel Tavares. "Establishment of pancreatic cancer zebrafish xenografts for personalized medicine in oncology practice". Master, 2021. http://hdl.handle.net/10451/49546.
  8. Belo, João Brito Colaço Carvalho. "Sensitivity profile of triple-negative breast cancer cell lines to combination therapies including RANKL blockade". Master, 2020. http://hdl.handle.net/10451/48310.
  9. Ferreira, Pedro Miguel Félix Pereira. "Quimiorresistência induzida por sobreexpressão de RANK em cancro da mama do sub-tipo luminal". Master, 2019. http://hdl.handle.net/10451/43566.
  10. Alves, Patrícia Borges, 1993-; Casimiro, Sandra. "YB-1 expression in breast cancer: modulation of receptor status and therapeutic implications". Master, Universidade de Lisboa Faculdade de Medicina, 2019. http://hdl.handle.net/10451/39449.
  11. Bello, Ana Rita de Sousa Noia de Mendonça. "The role of YB­-1 in acquired resistance to hormone therapy in breast cancer". Master, 2019. http://hdl.handle.net/10451/42741.
  12. Rocha, José Vicente Domingues Almeida Craveiro. "Prognostic role of secreted YB-1 in patients with breast cancer". Master, 2019. http://hdl.handle.net/10451/43228.
  13. Abreu, Catarina Pinheiro Barracha Pinto de; Casimiro, Sandra. "Brain metastases : immune characterisation and the impact over prognosis". Master, Universidade de Lisboa Faculdade de Medicina, 2019. http://hdl.handle.net/10451/39444.
  14. Correia, Inês André; Casimiro, Sandra Cristina Cara de Anjo, 1973-. "Analysis of the effect of the over-expression of recptor activator of Nf-kB (RANK) in estrogen receptor-positive breast cancer cells over tumour behaviour in vivo". Master, Universidade de Lisboa Faculdade de Medicina, 2017. http://hdl.handle.net/10451/33232.
  15. Bettencourt, Maria José Palma; Casimiro, Sandra Cristina Cara de Anjo, 1973-; Ramos, Maria Margarida Perestrelo. "Y-box binding protein 1 (YB-1) relevance in estrogen receptor-positive (ER+) breast cancer". Master, Universidade de Lisboa Faculdade de Ciências, 2016. http://hdl.handle.net/10451/23860.
  16. Costa, Luís, 1961-; Casimiro, Sandra Cristina Cara de Anjo, 1973-; Costa, Joana Maria Tato Ribeiro da, 1983-. "Effects of chemotherapy and radiotherapy in rectal cancer : significance of different cellular outcomes in tumor behavior". PhD, 2015. http://hdl.handle.net/10451/17816.
  17. Casimiro, Sandra. "Diana Matos. Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents. Evaluation of the effects of new compounds in breast and prostate cancer cell lines, cell outcome and assessment of the mechanisms of action". Master, Universidade de Lisboa Faculdade de Medicina, 2015.
  18. Casimiro, Sandra. "Sara Henriques. Luminal-type breast cancer: prognostic value of RANK-positive lymphatic nodes: RANK+ luminal breast cancer in vitro". Master, Universidade de Lisboa Faculdade de Medicina, 2015.

Intellectual property

Provisional application for patent
  1. 2020. "RANK pathway inhibitors in combination with CDK4/6 inhibitors".
    Disclosed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10/14 RANKL-RANK pathway in hormone-dependent breast cancer II ASPIC-ASEICA International Meeting
2020/02/05 RANKing estrogen receptor-positive breast cancer IBIMED Seminars
Universidade de Aveiro IBIMED (Aveiro, Portugal)
2019/01/18 Brain Metastases: immune characterisation and the impact over prognosis XI Congresso Nacional Neuro-Oncologia.
(Lisboa, Portugal)
2018/10/15 Elevated Receptor Activator of NFkB expression drives stemness and chemoresistance in ER+/HER2- breast cancer Seminar Series
Oslo University Hospital (Oslo, Norway)
2018/07 Network-based penalized logistic regression for the identification of common gene signatures in breast and prostate cancers Data Science, Statistics and Visualisation (DSSV 2018).
(Vienna, Austria)
2018/06 Prognostic role of secreted YB-1 in patients with breast cancer 8th International Conference on Tumor Microenvironment, Progression, Therapy & Prevention.
(Lisboa, Portugal)
2018/03/14 Pathophysiology of bone metastases - Understanding the main methods for target identification in preclinical studies Perceptorship in Bone Metastases: From the bone to the best treatment
Hospital de Santa Maria e IMM (Portugal)
2018/03/08 Valor prognóstico e terapêutico do Receptor Activador do NFkB (RANK) em cancro da mama Fundo iMM Laço - Meeting with Society
Instituto de Medicina Molecular (Portugal)
2017/10/26 RANK – RANKL signaling pathway in the context of breast cancer and bone metastases Seminar Series
Oslo University Hospital (Oslo, Norway)
2017/10/13 Multiple ways of imaging human breast cancer xenografts and metastases in mice Workshop on Preclinical Small Animal In Vivo Imaging
Instituto de Medicina Molecular and C2TN-IST (Portugal)
2017/01/27 Pathophysiology of bone metastases - Understanding the main methods for target identification in preclinical studies Perceptorship in Bone Metastases: From the bone to the best treatment
Hospital de Santa Maria e IMM (Portugal)
2016/05/18 Pathophysiology of bone metastases - Understanding the main methods for target identification in preclinical studies Perceptorship in Bone Metastases: From the bone to the best treatment
Hospital de Santa Maria e IMM (Portugal)
2016/05 Secreted YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases 43rd Annual European Calcified Tissue Society Congress.
(Rome, Italy)
2016/04/08 Preventing bone metastases in ER-positive breast cancer: Identification and clinical validation of putative prognostic biomarkers and therapeutic targets Jornadas de Investigação em Oncologia.
LPCC (Lisboa, Portugal)
2015/04/14 Pathophysiology of bone metastases - Understanding the main methods for target identification in preclinical studies Perceptorship in Bone Metastases: From the bone to the best treatment.
Hospital de Santa Maria e IMM (Portugal)
2013/12/12 Identification of prognostic factors and therapeutic targets in breast and colon cancer Lançamento da Rede Nacional de Bancos de Tumores.
IPO Lisboa (Portugal)
2013/09/18 Biobanking in Oncology: Experience from IMM-HSM The 3rd Global Cancer Genomics Consortium Symposium.
GCGC (Portugal)
2013/03/19 Bone Metastases: Searching for New Targets The 3rd Global Cancer Genomics Consortium Symposium.
GCGC (Portugal)
2012/10/10 Pathophysiology of Bone Metastasis in Breast Cancer Cancer Series
Escola Superior de Saúde de Lisboa (Portugal)
2011/10/19 Pathophysiology of bone metastases XXXI National Congress of Orthopedics and Traumatology.
(Lisboa, Portugal)
2010/12/11 Effect of RANK-RANKL signalling pathway on MMP1, MMP9, OPG and PTHrP gene expression of breast and prostate cancer cell lines in vitro EnjoyMed
Faculdade de Medicina da Universidade de Lisboa (Portugal)
2010/10/15 Effect of RANK-RANKL signalling pathway on MMP1, MMP9, OPG and PTHrP gene expression of breast and prostate cancer cell lines in vitro European Students Conference.
(Berlim, Germany)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - Current Strategies to overcome RANK-mediated resistance to TRAIL-induced apoptosis in luminal breast cancer
Supervisor of João Gaio
 Medicine (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/09 - Current Immune response in murine breast cancer allografts treated with OPG-Fc and CDK4/6 inhibitors
Supervisor of Rúben Vilela
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - Current Effect of insulin on proliferation and response to estradiol and progesterone of RANK-positive Luminal breast cancers
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - Current Comparative analysis of tumor infiltrating lymphocytes and PD-1/PD-L1 expressions between primary tumors and bone metastasis in solid cancers
Co-supervisor of Joaquim Brito
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/09/01 - Current RANK-pathway as a mediator of resistance to cyclin inhibitors and HER2-targeted therapies in breast cancer
Supervisor of Inês Gomes
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular, Portugal
2020 - 2022 Effect of RANK+ breast cancer cells’ secretome in monocytic differentiation
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2021 Tradução independente de cap da proteína humana up-frameshift 1 (UPF1) e cancro
Co-supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2021 Effect of prolonged RANKL-blockade with OPG-Fc in RANK-overexpressing Luminal Breast Cancer
Supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2021 The role of RANKL/RANK pathway on ER+ breast cancer’s tumorigenesis and resistance to therapy
Supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2021 Ikaros and C14ORF143-dependent Cell Competition on Basal Cell Carcinoma
Co-supervisor of Joana Jesus
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2021 Transcriptomic analysis of cancer cells with winner and loser behaviour
Co-supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2021 Establishment of pancreatic cancer zebrafish xenografts and therapies
Co-supervisor of Mariana Barroso
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2021 Efficacy of OPG-Fc plus palbociclib to treat RANK overexpressing CDKi-resistant breast cancer: a proof-of-concept xenograft trial
Supervisor of Francisco Baptista
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2021 Tackling the mystery of the “small xenografts”: RANK-pathway activation in RANK overexpressing breast cancer xenografts in an immune deficient mouse host
Supervisor of Guilherme Vilhais
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2020 Sensitivity profile of triple-negative breast cancer cell lines to combination therapies including RANKL blockade
Supervisor of João Belo
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2019 YB-1 expression in breast cancer: modulation of receptor status and therapeutic implications
Supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 Brain Metastases: immune characterisation and the impact over prognosis
Co-supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 The role of YB-1 in acquired resistance to hormone therapy in breast cancer
Supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 Prognostic role of secreted YB-1 in patients with breast cancer
Supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 Quimiorresistência Induzida por Sobreexpressão de RANK em Cancro da Mama do Sub-tipo Luminal
Supervisor
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019 Source of secreted YB-1 in breast cancer microenvironment
Supervisor of Ana Rita Bello
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019 Prognostic role of secreted YB-1 in patients with breast cancer
Supervisor of José Rocha
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09 - 2019 Impact of YB-1 expression in breast cancer outcomes under estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-targeted therapies
Supervisor of Patrícia Alves
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09 - 2019 Brain metastases immune characterization and the impact over prognosis
Co-supervisor of Catarina Abreu
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2017 Analysis of the effect of the over-expression of receptor activator of NF-κB (RANK) in estrogen receptor-positive breast cancer cells over tumour behaviour in vivo
Supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2017 Analysis of the effect of the over-expression of receptor activator of NF¿B (RANK) in estrogen receptor-positive breast cancer cells over lymphatic and distant metastasis in an orthotopic mouse model
Supervisor of Inês Correia
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016 Impact of estrogen receptor (ER)-dependent genes on breast cancer relapse to bone
Supervisor of Maria Bettencourt
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Luminal-type breast cancer: prognostic value of RANK-positive lymphatic nodes RANK+ Luminal Breast cancer in vitro approach.
Supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2015 "Synthesis, characterization and biological assessment of multi-functional bone-seeking agents. Evaluation of the effects of new compounds in breast and prostate cancer cell lines, cell outcome and assessment of the mechanisms of action"
Supervisor
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015 Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents. Evaluation of the effects of new compounds in breast and prostate cancer cell lines, cell outcome and assessment of the mechanisms of action
Supervisor of Diana Matos
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015 Luminal-type breast cancer: prognostic value of RANK-positive lymphatic nodes: RANK+ luminal breast cancer in vitro
Supervisor of Sara Henriques
 Oncobiologia (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2015 Effects of chemotherapy and radiotherapy in rectal cancer: significance of different cellular outcomes in tumour behavior
Co-supervisor of Joana Tato-Costa
 Ciências Biomédicas
Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular, Portugal
2010 - 2011 Desenvolvimento de terapias anti-RANKL para a doença metastática óssea
Supervisor of Sofia Ribeiro
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2011 Papel da metaloproteinase-1 na metastização tumoral
Supervisor of Rui Teixeira
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - 2020 EACR-AACR-ASPIC Conference: Tumor Microenvironment. (2020)
Congress (Member of the Scientific Committee)
2018/03/13 - 2018/03/14 Perceptorship in Bone Metastases: From the bone to the best treatment (2018/03/13 - 2018/03/14)
Workshop (Member of the Organising Committee)
 Hospital de Santa Maria, Portugal

Instituto de Medicina Molecular, Portugal
2017 - 2018 3rd International Congress of ASPIC (2018/05/10 - 2018/05/11)
Congress (Member of the Organising Committee)
2017 - 2018 The 8th International Conference of ICMS (2018/06/10 - 2018/06/14)
Congress (Member of the Scientific Committee)
2017/01/26 - 2017/01/27 Perceptorship in Bone Metastases: From the bone to the best treatment (2017/01/26 - 2017/01/27)
Workshop (Member of the Organising Committee)
 Hospital de Santa Maria, Portugal

Instituto de Medicina Molecular, Portugal
2016/05/17 - 2016/05/18 Perceptorship in Bone Metastases: From the bone to the best treatment (2016/05/17 - 2016/05/18)
Workshop
 Hospital de Santa Maria, Portugal

Instituto de Medicina Molecular, Portugal
2015/04/13 - 2015/04/14 Perceptorship in Bone Metastases: From the bone to the best treatment (2015/04/13 - 2015/04/14)
Workshop (Member of the Organising Committee)
 Hospital de Santa Maria, Portugal

Instituto de Medicina Molecular, Portugal
2012 - 2013 GCGC Meeting 2013 (2013 - 2013)
Congress (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/10/11 - Current Cancer, Science and Me - Cabify Staff
Seminar
Instituto de Medicina Molecular, Portugal
2018/10/30 - 2018/10/30 Cancer, Science and Me
Seminar
Hotéis Real, Portugal
2018/10/03 - 2018/10/03 Cancer, Science and Me
Seminar
Hotéis Real, Portugal
2017/11/10 - 2017/11/10 Cancer, Science and Me
Seminar
Willis Towers Watson Plc, United Kingdom
2017/03/30 - 2017/03/30 Cancer, Science and Me - High school students
Seminar
Ministério da Educação, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/07/07 Circulating Tumour Cells Detection in Renal Cell Carcinoma
(Thesis) Main arguer
 Ana Margarida Rodrigues (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/07/07 Estudo dos fatores preditivos de resposta patológica completa à quimioterapia neoadjuvante em neoplasias da mama do tipo luminal B
President of the jury
 Daniela Batista (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/05/24 O LDL-Colesterol na Agressividade do Cancro da Mama HER2+ e na Sensibilidade ao Trastuzumab
(Thesis) Main arguer
 Emanuel Estevez de Oliveira (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/04/19 Developing of novel therapeutics for breast cancer: targeting the Notch ligand DLL1
(Thesis) Arguer
 Joana Sales-Dias (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/02/26 Nanoplatform to modulate dendritic cells and tumor microenvironment against triple negative breast cancer
(Thesis) Main arguer
 Mafalda Carvalho Verdial (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/24 Exploring epigenetic profiling as predictive/prognostic markers of endocrine resistence in estrogen positive breast cancer
(Thesis) Arguer
 Mário Filipe Teixeira de Fontes e Sousa (PhD)
Universidade do Porto, Portugal
2020/07/10 Caso Clínico – Tumor de Células Gigantes da Coluna Cervical
(Thesis) Main arguer
 Filipa Marques da Costa (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/12/03 Metastatic Breast Cancer: Finding Molecular Biomarkers in Liquid Biopsies
(Thesis) Main arguer
 Helena Estevão Pereira (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018/10/15 Non-invasive biomarkers of metabolic and immune profiles in cancer
(Thesis) Main arguer
 Shakila Jabeen (PhD)
Universitetet i Oslo Det medisinske fakultet, Norway
2018/01/09 The role of mithocondrial metabolism in breast cancer aggressive phenotype induced by hypercholesterolemia
(Thesis) Main arguer
 Maria Beatriz Morgado (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/06/21 Immunogenecity of Colorectal Cancer with Microsatellite Instability
President of the jury
 Inês do Vale Costa Santos (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 The role of mitochondrial adaptations in the acquisition of the phenotype induced by LDL in breast cancer
(Thesis) Main arguer
 Susana Monteiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Specific Features of Endothelial Cells in Primary Tumors
(Thesis) Main arguer
 Germana Domingues (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 Effect of Inflammation on Bone Biological, Structural and Mechanical Behaviour
Thesis Member
 Joana Lopes (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 Avaliação do comportamento dos osteoclastos em doenças reumáticas
(Thesis) Main arguer
 Inês Perpétuo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2019 - Current EACR Member
2018/01/09 - Current ASPIC - Associação Portuguesa de Investigação em Cancro Member

Committee member

Activity description
Role 		Institution / Organization
2013 - Current Reviewer Panel of the Animal Welfare Committee of the iMM Rodent Facility
Member
 Instituto de Medicina Molecular, Portugal
2011 - Current Scientific Committee of Biobank IMM
Member
 Instituto de Medicina Molecular, Portugal
2009/09/01 - Current Advisory Board of the Compared Histology and Comparative Pathology Lab
Member
 Instituto de Medicina Molecular, Portugal
2007 - Current Peer-Reviewer: Frontiers in Genetics, Sci Reports, BMC Urology, Gland Surgery, Cancers, BMC Cancer, Int Journal of Breast Cancer, Cells, Biomedicine and Pharmacotherapy, Cellular Physiology and Biochemistry; Oncotarget, Translational Research, Journal of Cancer Research and Clinical Oncology, Clin and Exp Metastasis, J of Thoracic Oncology, J of Clinical Medicine, Cellular Oncology, J of Inflammatory Research, Oncotargets and Therapy, Int Journal of Nanomedicine, PLOS One, Artificial Cells, Nanomedicine and Biotechnology, Cur Pharmaceutical Design
Other

Conference scientific committee

Conference name Conference host
2019/12/03 - 2020/09/25 Cancer Biology: From Basic to Translational Research Liga Portuguesa Contra o Cancro
2019 - 2020 EACR-AACR-ASPIC Conference: Tumor Microenvironment EACR-AACR-ASPIC
2017/06/10 - 2018/06/14 8th International Conference on Tumor Microenvironment. ICMS
2017/06/14 - 2018/05/11 3rd International Congress of ASPIC. ASPIC
2013 - 2014 The Global Cancer Genomics Consortium’s Third Annual Symposium: From Oncogenomics to Cancer Care. GCGC

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012 - Current Molecular Biology and Gene Expression Oncobiologia (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - Current Development of New Drugs in Oncology Oncobiologia (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2009/02/01 - Current Oncobiology Medicina (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2005 - 2006 Molecular Biology Practical Course (Curso de Especialização Tecnológica) Universidade de Lisboa Faculdade de Ciências, Portugal
2001 - 2003 Theoretical and Practical Course of Molecular Taxonomy (Curso de Especialização Tecnológica) Universidade de Lisboa Faculdade de Ciências, Portugal
1996 - 2001 Biology Biologia (Ensino secundário) Ministério da Educação, Portugal
1994 - 2001 Biology Biologia (Ensino básico 3º ciclo) Ministério da Educação, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021 - Current KWF Kankerbestrijding – Dutch Cancer Society
Evaluator
 KWF Kankerbestrijding, Netherlands
2020 - Current Research Grants - Instituto Português de Oncologia de Lisboa de Francisco Gentil, EPE
Evaluator
 Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2020 - Current GAPIC Research grants
Evaluator
 Universidade de Lisboa Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2018/03/05 Hair Fashion Weeks - Fund raising - Breast Cancer Research Máxima
2018/02/20 Hair Fashion Weeks - Fund raising - Breast Cancer Research Activa
2018/02/02 Hair Fashion Weeks - Fund raising - Breast Cancer Research Jean Louis David
2017/07/22 Why breast cancer kills - Research progresses Diário de Notícias

Interview (tv / radio show)

Program Topic
2019/11/25 - Current "Tudo a ver" Breast cancer research
2018/03/12 - 2018/03/12 CC All Stars Breast Cancer Research - Fund Raising
2017/06/03 - 2017/06/03 Retratos da Saúde Breast Cancer

Mentoring / Tutoring

Topic Student name
2019 - 2020 Effect of RANK+ breast cancer cells’ secretome in monocytic differentiation Laura Castro
2018 - 2020 Efficacy of OPG-Fc plus palbociclib to treat RANK overexpressing CDKi-resistant breast cancer: a proof-of-concept xenograft trial Francisco Baptista
2018 - 2019 Tackling the mystery of the “small xenografts”: RANK-pathway activation in RANK overexpressing breast cancer xenografts in an immune deficient mouse host Guilherme Vilhais
2017 - 2018 Effect of the loss-of-function R450W mutation in the receptor activator of NF¿B (RANK) in the host immune response to breast cancer Inês Gomes
2017 - 2018 Evaluation of the effect of carboxyterminal telopeptide of type I collagen (ICTP) in the breast and prostate cancer cell lines functional properties Miguel Silvestre
2016 - 2017 Allelic frequency and plasticity of the RANK R450W mutation in germline and breast cancer DNA Pedro Félix
2016 - 2017 Prognostic role of secreted YB-1 in patients with breast cancer Ana Rita Bello e José Rocha
2013 - 2014 Luminal-type breast cancer: genetic variability of RANK gene locus and prognostic value of RANK-positive lymphatic nodes Raquel Brás e Marta Melo
2013 - 2014 Fragmentos de colagénio do tipo I, ICTP e CTX, como mediadores celulares em cancro da mama Pedro Dias
2010 - 2011 Via de sinalização RANK-RANKL na doença metastática óssea do cancro da mama: Transactivação de receptores e oportunidades terapêuticas – Efeito de terapias combinadas no comportamento in vitro de células tumorais Margarida Coelho
2009 - 2010 Efeito da via de sinalização RANK-RANKL na expressão génica de MMP1, MMP9, OPG e PTHrP em linhas celulares de cancro da mama e da próstata Sofia Ribeiro
2008 - 2009 Efeito da via de sinalização RANK-RANKL na expressão génica de MMP1 e capacidade invasiva de linhas celulares de cancro da mama e da próstata Rui Teixeira e António Carvalho
2007 - 2008 Caracterização bioquímica da matriz extracelular do tumor primário, metástase e estroma tumoral Ricardo Prata e António Oliveira
Distinctions

Award

2021 Pfizer Global Medical Grant - Metastatic Breast Cancer
Pfizer Portugal, Portugal
2016 iMM-Laço Clinical Grant
2014 Terry Fox Oncology Research Award
Liga Portuguesa Contra o Cancro, Portugal
2012 Merit Award in Translation Research in Breast Cancer
Sociedade Portuguesa de Senologia, Portugal
2009 EMBO Short Term Fellowship
2008 Travel Award, Calouste Gulbenkian Foundation
Fundação Calouste Gulbenkian, Portugal
2008 Terry Fox Oncology Research Award
Liga Portuguesa Contra o Cancro, Portugal
2007 Travel Award, International Society of Plant Pathology

Title

2021 Guest Associate Editor in Molecular and Cellular Oncology
Frontiers in Oncology, Switzerland
2021 Topical Advisory Panel Member
Cancers, Switzerland