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Nelson Pereira is a chemist with multidisciplinary expertise derived from rigorous academic preparation and 10+ years of research experience. He received his degree in Industrial Chemistry in 2005 from the University of Coimbra and obtained the MSc and Ph.D. degrees in Organic Chemistry in the same institution in 2008 and 2014, respectively. Throughout his research career, he integrated various projects, (PRIME/CLARO/3/293/2007; FCT SFRH/BD/61573/2009; PTDC/QEQ-MED/0262/2014; PTDC/EMD-TLM/30295/2017; PTDC/QUI-QFI/28973/2017), working and collaborating with researchers from different áreas (Chemical, Biological, Medical and Health Sciences; Physics). He participated in scientific missions joining as visiting researcher to international research groups of excellence at Trinity College Dublin (2011) and Utrecht University (2016 and 2018). He has experience of co-supervision and supporting undergraduate and graduate students, from various courses, Chemistry, Medicinal Chemistry, Dentistry, to achieve their academic goals. He was awarded 4 grants, a research fellowship from Chymiotechnon (2007), a Ph.D. Scholarship from the Foundation for Science and Technology (2009), two postdoctoral research fellowships (2016 and 2018) and 1 researcher position (2019) from the University of Coimbra. He has recognized research activity in organic, physical and medicinal chemistry. As a result, his work is actually (Fev., 2021) reported in various international peer-reviewed journals (15) and patents (2) and was presented in several conferences, oral communications (8) and posters (30+). Reviewing for scientific journals and participation as a jury member of academic degrees are other scientific activities in which he has been involved. Nelson Pereira is working as a researcher at the Laboratory for Molecular Cryospectroscopy and Biospectroscopy (LMCB) of the University of Coimbra. He is also lecturing courses in Organic Chemistry in the same institution. His main scientific research interests are the design and development of new theranostic agents for cancer. Recently, he has also been focusing his study on organic reactions induced by Infrared Vibrational Excitation.
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Identification

Personal identification

Full name
Nelson António Melo Pereira

Citation names

  • Nelson A. M. Pereira

Author identifiers

Ciência ID
0E1E-4CC0-C166
ORCID iD
0000-0002-1891-9010
Google Scholar ID
guzBeuYAAAAJ
Researcher Id
O-6055-2015
Scopus Author Id
36651561100

Email addresses

  • npereira@qui.uc.pt (Professional)

Telephones

Telephone
  • (351) 239854489 Ext.: voip264350 (Professional)

Addresses

  • Universidade de Coimbra, Faculdade de Ciências e Tecnologia, Departamento de Química. Rua Larga, 3004-535, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Elementary (A2)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Elementary (A2)
Education
Degree Classification
2014/12/19
Concluded
 Doutoramento em Química, ramo de Síntese Orgânica (Doutoramento)
Universidade de Coimbra, Portugal
"Reacções de Ciclo-Adição na Síntese de Novos Dipirrometanos e Hidroporfirinas" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2008/12/15
Concluded
 Mestrado em Química dos Processos Químicos (Mestrado)
Universidade de Coimbra, Portugal
"Síntese de Porfirinas beta-Subtituídas e Sua Aplicação em Terapia Fotodinâmica do Cancro" (THESIS/DISSERTATION)
 Muito Bom
2005/09/22
Concluded
 Química Industrial no Ramo de Controlo Químico da Qualidade (Licenciatura)
Universidade de Coimbra, Portugal
"Determinação de acrilamida em águas naturais - desenvolvimento do método por cromatografia gasosa" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2022/01 - Current Contracted Researcher (Research) United Resins - Produção de Resinas, S.A., Portugal
2019/06 - 2022/07 Contracted Researcher (Research) Universidade de Coimbra, Portugal
2019/02/01 - 2019/05/31 Postdoc (Research) Universidade de Coimbra, Portugal
2018/06/25 - 2018/11/30 Postdoc (Research) Universidade de Coimbra, Portugal
2016/06/01 - 2018/05/31 Postdoc (Research) Universidade de Coimbra, Portugal

Others

Category
Host institution 		Employer
2018/03/01 - 2018/03/31 Visiting researcher (Short-Term Scientific Mission) Universiteit Utrecht Departement Biologie, Netherlands
2016/11/13 - 2016/11/20 Visiting researcher (Short-Term Scientific Mission) Universiteit Utrecht Departement Biologie, Netherlands
2010/01/01 - 2013/12/31 PhD Student fellow - FCT Universidade de Coimbra, Portugal
2011/09/15 - 2011/12/15 Visiting researcher (Short-Term Scientific Mission) Trinity College Dublin School of Chemistry, Ireland
2007/01/01 - 2007/12/31 Research Fellow Instituto de Ciência, Tecnologia e Inovação em Química, Portugal
Projects

Grant

Designation Funders
2019/07/26 - 2021/07/25 Chemistry Triggered by Infrared Vibrational Excitation: Developing a Powerful Tool for Highly-Selective Molecular Structure Manipulation
PTDC/QUI-QFI/28973/2017
Researcher
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Single Pixel Imaging for phosphorescence lifetime measurements in biomedical markers
PTDC/EMD-TLM/30295/2017
Researcher
Universidade de Coimbra - Associação para o Desenvolvimento do Departamento de Física, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/01 - 2019/05/31 Novel Fused Ring Tetrapyrrolic Macrocycles as Highly Efficient Theranostic Agents for Cancer
PTDC/QEQ-MED/0262/2014
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/25 - 2018/11/30 Novel Fused Ring Tetrapyrrolic Macrocycles as Highly Efficient Theranostic Agents for Cancer
PTDC/QEQ-MED/0262/2014
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2018/05/30 Novel Fused Ring Tetrapyrrolic Macrocycles as Highly Efficient Theranostic Agents for Cancer
BPD grant -PTDC/QEQ-MED/0262/2014
PTDC/QEQ-MED/0262/2014
Post-doc Fellow
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/12 Cycloaddition Reactions in the Synthesis of New Dipyrromethanes and Hydroporphyrins
SFRH/BD/61573/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2007/12/31 Cancer Light Assisted Receding Oncology (CLARO)
PRIME/CLARO/3/293
Research Fellow
Institute of Science, Technology and Innovation in Chemistry - CHYMIOTECHNON, Portugal
 Ministério da Economia
Concluded
Outputs

Publications

Conference abstract
  1. Brites, Gonçalo; Laranjo, Mafalda; Pereira, Nelson A.M.; Campos, Márcia; Oliveira, Andreia S.R.; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "PO-423 Novel 4, 5, 6, 7-tetrahydropyrazolo [1, 5-a] pyridine fused chlorins as very active photosensitizers against melanoma and bladder cancer cells". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands (June 30 -July 3, 2018), Amsterdam, 2018.
    10.1136/esmoopen-2018-EACR25.449
  2. Campos, Márcia; Nelson A. M. Pereira; Laranjo, Mafalda; Nascimento, Bruno F. O.; Brites, Gonçalo; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "PO-422 Disaggregation in biological medium of promising theranostic agents for cancer". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands (June 30 -July 3, 2018), Amsterdam, 2018.
    10.1136/esmoopen-2018-EACR25.448
Conference paper
  1. Paula, Anabela; Ferreira, Maria Beatriz; Laranjo, Mafalda; Marto, Carlos Miguel; Amaro, Inês; Spagnuolo, Gianrico; Marques Ferreira, Manuel; et al. "Isolation and Identification of Cytotoxic Compounds Present in Biomaterial Life". Paper presented in 1st International Electronic Conference on Applied Sciences, 2020.
    Accepted • 10.3390/asec2020-07641
  2. Dias-Ferreira, J.; Pereira, Nelson A.M.; Laranjo, Mafalda; Pineiro, Marta; Casalta-Lopes, João; Abrantes, Ana Margarida; Pinho e Melo, Teresa M.V.D.; Botelho, Maria Filomena. "Advances on photodynamic therapy through new pyridine-fused diphenylchlorins as photosensitizers for melanoma treatment". 2017.
    10.1016/j.pbj.2017.07.119
Conference poster
  1. Roque, José P. L.; Nunes, Cláudio M.; Viegas, Luís P.; Nelson A. M. Pereira; Pinho e Melo, Teresa M. V. D.; Fausto, Rui. "H-Tunneling Activated by Vibrational Excitation". Paper presented in 14th Meeting of Physical Chemistry, 2021.
  2. Simões, João C. S; Pereira, Nelson A. M.; Nascimento, Bruno F. O.; Oliveira, Andreia S.R.; Pineiro, Marta; Pina, João; Seixas de Melo, J. Sérgio; Pinho e Melo, Teresa M. V. D.. "Novel PEGylated 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine–fused Chlorins". Paper presented in 12th Organic Chemistry/ 5th Therapeutic Portuguese National Meetings, Coimbra, Portugal (January 17-19, 2018), 2018.
  3. Campos, Márcia; Pereira, Nelson A. M.; Nascimento, Bruno F. O.; Laranjo, Mafalda; Brites, Gonçalo; Pineiro, Marta; Botelho, M. Filomena; Pinho e Melo, Teresa M. V. D.. "Novel platinum (II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins as promising theranostic agents for cancer treatment". Paper presented in 12th Organic Chemistry/ 5th Therapeutic Portuguese National Meetings, Coimbra, Portugal (January 17-19, 2018), 2018.
  4. Simões, João C. S; Laranjo, Mafalda; Pereira, Nelson A. M.; Brites, Gonçalo; Nascimento, Bruno F. O.; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "Cytotoxicity of Novel Pyridine-fused Chlorins as promising PDT agents against oesophagus cancer cell line". Paper presented in 3rd ASPIC International Congress, Lisbon, Portugal (May 10-11, 2018), 2018.
  5. Campos, Márcia; Piñeiro, Marta; Brites, Gonçalo; Pereira, Nelson A. M.; Laranjo, Mafalda; Nascimento, Bruno F. O.; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "Aggregation in Biological Medium of Promising Theranostic Agents for Cancer: An unwanted Reality". Paper presented in 3rd ASPIC International Congress, Lisbon, Portugal (May 10-11, 2018), 2018.
  6. Brites, Gonçalo; Laranjo, Mafalda; Pereira, Nelson A. M.; Campos, Márcia; Oliveira, Andreia S.R.; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "PDT based on novel 4,5,6,7 - tetrahydropyrazolo [1,5-a] pyridine fused chlorins against melanoma, bladder, and oesophagus cancer cells". Paper presented in 3rd ASPIC International Congress, Lisbon, Portugal (May 10-11, 2018), 2018.
  7. Simões, João C. S; Pereira, Nelson A. M.; Nascimento, Bruno F. O.; Pineiro, Marta; Botelho, M. Filomena; Laranjo, Mafalda; Brites, Gonçalo; Pinho e Melo, Teresa M. V. D.. "A new generation of ring-fused chlorins as promising PDT agents". Paper presented in 6th Portuguese Young Chemists Meeting, Setúbal, Portugal (May 15-18, 2018), 2018.
  8. Campos, Márcia; Pereira, Nelson A. M.; Nascimento, Bruno F. O.; Laranjo, Mafalda; Brites, Gonçalo; Pineiro, Marta; Botelho, M. Filomena; Pinho e Melo, Teresa M. V. D.. "Synthesis and characterization of promising theranostic agents for cancer". Paper presented in 6th Portuguese Young Chemists Meeting, Setúbal, Portugal (May 15-18, 2018), 2018.
  9. Campos, Márcia; Pereira, Nelson A. M.; Laranjo, Mafalda; Nascimento, Bruno F. O.; Brites, Gonçalo; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "Disaggregation in biological medium of promising theranostic agents for cancer". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands (June 30 -July 3, 2018), 2018.
  10. Brites, Gonçalo; Laranjo, Mafalda; Pereira, Nelson A. M.; Campos, Márcia; Oliveira, Andreia S.R.; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "Novel 4, 5, 6, 7-tetrahydropyrazolo [1, 5-a] pyridine fused chlorins as very active photosensitizers against melanoma and bladder cancer cells". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands (June 30 -July 3, 2018), 2018.
  11. Nascimento, Bruno F. O.; Pereira, Nelson A. M.; Brites, Gonçalo; Laranjo, Mafalda; Pineiro, Marta; Botelho, M. Filomena; Pinho e Melo, Teresa M. V. D.. "Novel temoporfin-related 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins: synthetic details, structural characterization and cytotoxicity evaluation". Paper presented in Photodynamic Therapy and Photodiagnosis Update, Kochel am See, Germany (September 18-22, 2018), 2018.
  12. Nelson A. M. Pereira; Mashayekhi, Vida; Laranjo, Mafalda; Hernandez, Irati B.; Pineiro, Marta; Botelho, M. Filomena; Oliveira, Sabrina; Pinho e Melo, Teresa M. V. D.. "Promising nanobody-ring-fused chlorin conjugate as potential agent for targeted photodynamic therapy of cancer". Paper presented in Photodynamic Therapy and Photodiagnosis Update, Kochel am See, Germany (September 18-22, 2018), 2018.
  13. Fonseca, Inês; Lopes, Susana M. M.; Pereira, Nelson A. M.; Pinho e Melo, Teresa M. V. D.. "Exploring the Chemistry of Nitroso- and Azoalkenes for the Synthesis of Bilanes". Paper presented in XXV Portuguese Chemical Society National Meeting (XXVEN-SPQ), Lisbon, Portugal (July 16-19, 2017), 2017.
  14. Oliveira, Andreia S.R.; Pereira, Nelson A. M.; Laranjo, Mafalda; Piñeiro, Marta; Botelho, M. Filomena; Pinho e Melo, Teresa M. V. D.. "4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-fused chlorins as novel photosensitizers". Paper presented in 16th International Photodynamic Association World Congress, Coimbra, Portugal (June 8-13, 2017), 2017.
  15. Laranjo, Mafalda; Piñeiro, Marta; Brito, Ana; Pereira, Nelson A. M.; Abrantes, Ana M.; Pina, João; Botelho, M. Filomena; Seixas de Melo, J.S.; Pinho e Melo, Teresa M. V. D.. "Multifunctional Platinum(II) Ring-fused Chlorins for Theranostics". Paper presented in 16th International Photodynamic Association World Congress, Coimbra, Portugal (June 8-13, 2017), 2017.
  16. Nelson A. M. Pereira; Oliveira, Andreia S.R.; Piñeiro, Marta; Laranjo, Mafalda; Ferreira, João D.; Botelho, M. Filomena; Pinho e Melo, Teresa M. V. D.. "Novel Ring-Fused Diarylchlorins as Very Active Photodynamic Agents Against Cancer Cells". Paper presented in 16th International Photodynamic Association World Congress, Coimbra, Portugal (June 8-13, 2017), 2017.
  17. Nelson A. M. Pereira; Piñeiro, Marta; Laranjo, Mafalda; Oliveira, Andreia S.R.; Botelho, M. Filomena; Burrows, Hugh D.; Pinho e Melo, Teresa M. V. D.. "Highly Efficient Theranostics Agents for Cancer". Paper presented in Ciência 2016 - Science and Technology in Portugal Meeting, Lisbon, Portugal, (July 4-6, 2016), 2016.
  18. Ferreira, João Dias; Pereira, Nelson A. M.; Laranjo, Mafalda; Pineiro, Marta; Casalta-Lopes, João; Abrantes, Ana M.; Pinho e Melo, Teresa M. V. D.; Botelho, M. Filomena. "Cytotoxicity studies on novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused diphenylchlorins as photosensitizers in human melanoma cells". Paper presented in 11th YES Meeting, Porto, Portugal (September 15-18, 2016), 2016.
  19. Ferreira, Ana R. F.; Pereira, Nelson A. M.; Lopes, Susana M. M.; Pinho e Melo, Teresa M. V. D.. "Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine Fused Chlorins: a novel type of photosensitizers for cancer treatment". Paper presented in 2nd Symposium on Medicinal Chemistry of the University of Minho, Braga, Portugal, (May 8, 2015), 2015.
  20. Ferreira, Ana R. F.; Pereira, Nelson A. M.; Lopes, Susana M. M.. "Photophysical Characterization of Porphyrinic Derivates for Biomedical Application". Paper presented in XXIV Portuguese Chemical Society National Meeting (XXIV EN-SPQ), Coimbra, Portugal, (July 1-3, 2015), 2015.
    10.1109/iecbes.2014.7047549
  21. Nelson A. M. Pereira; Martelo, Liliana; Serra, Arménio C.; Santos, Mário N. Berbaran; Fonseca, Sofia M.; Pinho e Melo, Teresa M. V. D.; Burrows, Hugh D.. "Highly Stable Platinum(II) Fused-ring Chlorins as Near-Infrared Emitting Ratiometric Probes for Molecular Oxygen". Paper presented in 11th Organic Chemistry/ 4th Therapeutic Portuguese National Meetings, Porto, Portugal, (December 1-3, 2015), 2015.
  22. Lopes, Susana M. M.; Pereira, Nelson A. M.; Lemos, Américo; Pinho e Melo, Teresa M. V. D.. "Hetero-Diels-Alder of 3-Tetrazolyl-1,2-diaza-1,3-butadiene with Dipyrromethanes". Paper presented in 10th Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium, Lisboa, Portugal, (September 4-6, 2013), 2013.
  23. Pereira, Nelson A. M.; Lemos, Américo; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.. "Functionalization of Dipyrromethanes via Hetero-Diels–Alder Reaction with Azo- and Nitrosoalkenes". Paper presented in 13th Belgian Organic Synthesis Symposium, 2012.
  24. Pereira, Nelson A. M.; Fonseca, Sofia M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.; Burrows, Hugh D.. "New Chlorins and Bacteriochlorins: Stable Red and Near-Infrared Absorbing Molecules". Paper presented in 24th IUPAC Symposium on Photochemistry, Coimbra, Portugal, (July 15-20, 2012), 2012.
  25. Pereira, Nelson A. M.; Pineiro, Marta; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.; Laranjo, Mafalda; Abrantes, Ana M.; Botelho, Maria F.. "4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-fused Chlorins as Efficient Photosensitizers for PDT Against Melanoma Cancer Cells". Paper presented in 6th Spanish Portuguese Japanese Organic Chemistry Symposium, Lisbon, Portugal, (July 18-20, 2012), 2012.
  26. Lopes, Susana M. M.; Pereira, Nelson A. M.; Lemos, Américo; Pinho e Melo, Teresa M. V. D.. "Hetero-Diels-Alder of 3-Tetrazolyl-1,2-diaza-1,3-butadiene with Dipyrromethanes". Paper presented in 13th Belgian Organic Synthesis Symposium. Leuven, Belgium, (July 15-20, 2012), 2012.
  27. Pereira, Nelson A. M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.. "Synthesis of New 5,15-Diarylchlorins via [8pi+2pi] Cycloaddition of Diazafulvenium Methides with 5,15-Diarylporphyrins". Paper presented in 17th European Symposium on Organic Chemistry. Crete, Greece, (July 10-15, 2011), 2011.
  28. Pereira, Nelson A. M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.; Ebrahim, Mothi M.; Senge, Mathias O.. "Synthesis of New Chlorins and Bacteriochlorins via [8pi+2pi] Cycloaddition of Diazafulvenium Methides with Porphyrins". Paper presented in 10th CSCB symposium, Dublin, Ireland, (December 9, 2011), 2011.
  29. Pereira, Nelson A. M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.. "Novel Approach to Chlorin and Bacteriochlorin Type Macrocyles: [8pi+2pi] Cycloaddition of Diazafulvenium Methides with Porphyrins". Paper presented in 3rd EuCheMS Chemistry Congress, Nuremberg, Germany, (August/September 29-2, 2010), 2010.
  30. Pereira, Nelson A. M.; Serra, Arménio C.; Rocha Gonsalves, António M.d’A; Abrantes, Ana M.; Laranjo, Mafalda; Santos, Ana C.; Botelho, Maria F.. "N-alkyloxysulfamoylphenylporphyrins: Synthesis and Photodynamic Effect Against Colon Carcinoma Cells". Paper presented in 7th Internacional Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice, Bressanone, Italy, (October 7-11, 2008), 2008.
  31. Pereira, Nelson A. M.; Serra, Arménio C.; Pineiro, Marta; Rocha Gonsalves, António M.d’A; Abrantes, Ana M.; Laranjo, Mafalda; Botelho, Maria F.. "Activity of Beta-Substituted Porphyrins with Propionic Groups in Photodynamic Therapy". Paper presented in 7th Portuguese National Meeting of Organic Chemistry, Lisbon, Portugal, (July 16-18, 2007), 2007.
Journal article
  1. Mata, Ana I.; Pereira, Nelson A.M.; Cardoso, Ana L.; Nascimento, Bruno F.O.; Pineiro, Marta; Schaberle, Fábio A.; Gomes-da-Silva, Lígia C.; Brito, Rui M.M.; Pinho e Melo, Teresa M.V.D.. "Novel Foscan®-derived ring-fused chlorins for photodynamic therapy of cancer". Bioorganic & Medicinal Chemistry 93 (2023): 117443. http://dx.doi.org/10.1016/j.bmc.2023.117443.
    10.1016/j.bmc.2023.117443
  2. Sousa, Francisco JPM; Jesus, Carolina F; Góis, Joana R; Pereira, Nelson AM; Antunes, Filipe E. "Microcrystalline cellulose and by-products from the pulp and paper industry as reinforcing fibres for polybutylene succinate-based composites: A comparative study". Journal of Reinforced Plastics and Composites (2023): http://dx.doi.org/10.1177/07316844231198314.
    10.1177/07316844231198314
  3. Nunes, Cláudio M.; Doddipatla, Srinivas; Loureiro, Gonçalo F.; Roque, José P. L.; Pereira, Nelson A. M.; Pinho e Melo, Teresa M. V. D.; Fausto, Rui. "Differential Tunneling-Driven and Vibrationally-Induced Reactivity in Isomeric Benzazirines". Chemistry – A European Journal 28 67 (2022): http://dx.doi.org/10.1002/chem.202202306.
    10.1002/chem.202202306
  4. Laranjo, Mafalda; Pereira, Nelson A. M.; Oliveira, Andreia S. R.; Campos Aguiar, Márcia; Brites, Gonçalo; Nascimento, Bruno F. O.; Serambeque, Beatriz; et al. "Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation". Frontiers in Chemistry 10 (2022): http://dx.doi.org/10.3389/fchem.2022.873245.
    10.3389/fchem.2022.873245
  5. Nunes, Cláudio M.; Pereira, Nelson A. M.; Fausto, Rui. "Photochromism of a Spiropyran in Low-Temperature Matrices: Unprecedented Bidirectional Switching between a Merocyanine and an Allene Intermediate". The Journal of Physical Chemistry A 126 14 (2022): 2222-2233. http://dx.doi.org/10.1021/acs.jpca.2c01105.
    10.1021/acs.jpca.2c01105
  6. Ferreira, Maria Beatriz; Pereira, Nelson A. M.; Marto, Carlos Miguel; Cardoso, Miguel; Amaro, Inês; Coelho, Ana; Saraiva, José; et al. "Isolation and Identification of Cytotoxic Compounds Present in Biomaterial Life®". Materials 15 3 (2022): 871. http://dx.doi.org/10.3390/ma15030871.
    10.3390/ma15030871
  7. Pereira, Nelson A. M.; Nunes, Cláudio M.; Reva, Igor; Fausto, Rui. "Evidence of IR-Induced Chemistry in a Neat Solid: Tautomerization of Thiotropolone by Thermal, Electronic, and Vibrational Excitations". The Journal of Physical Chemistry A 125 29 (2021): 6394-6403. http://dx.doi.org/10.1021/acs.jpca.1c04081.
    10.1021/acs.jpca.1c04081
  8. Roque, José P. L.; Nunes, Cláudio M.; Viegas, Luís P.; Pereira, Nelson A. M.; Pinho e Melo, Teresa M. V. D.; Schreiner, Peter R.; Fausto, Rui. "Switching on H-Tunneling through Conformational Control". Journal of the American Chemical Society 143 22 (2021): 8266-8271. http://dx.doi.org/10.1021/jacs.1c04329.
    10.1021/jacs.1c04329
  9. Pereira, Nelson A. M.; Laranjo, Mafalda; Nascimento, Bruno F. O.; Simões, João C. S.; Pina, João; Costa, Bruna D. P.; Brites, Gonçalo; et al. "Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer". RSC Medicinal Chemistry 12 4 (2021): 615-627. http://dx.doi.org/10.1039/d0md00433b.
    Published • 10.1039/d0md00433b
  10. M. Nunes, Cláudio; Pereira, Nelson A. M.; Viegas, Luís P.; Pinho e Melo, Teresa M. V. D.; Fausto, Rui. "Inducing molecular reactions by selective vibrational excitation of a remote antenna with near-infrared light". Chemical Communications (2021): http://dx.doi.org/10.1039/d1cc03574f.
    10.1039/d1cc03574f
  11. Nunes, Cláudio M.; Pereira, Nelson A. M.; Reva, Igor; Amado, Patrícia S. M.; Cristiano, Maria L. S.; Fausto, Rui. "Bond-Breaking/Bond-Forming Reactions by Vibrational Excitation: Infrared-Induced Bidirectional Tautomerization of Matrix-Isolated Thiotropolone". The Journal of Physical Chemistry Letters 11 19 (2020): 8034-8039. http://dx.doi.org/10.1021/acs.jpclett.0c02272.
    10.1021/acs.jpclett.0c02272
  12. Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A.M.; Brites, Gonçalo; Nascimento, Bruno F.O.; Brito, Ana F.; Casalta-Lopes, João; et al. "Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer". European Journal of Medicinal Chemistry 200 (2020): 112468. http://dx.doi.org/10.1016/j.ejmech.2020.112468.
    10.1016/j.ejmech.2020.112468
  13. Nascimento, Bruno F. O.; Laranjo, Mafalda; Pereira, Nelson A. M.; Dias-Ferreira, João; Piñeiro, Marta; Botelho, Maria Filomena; Pinho e Melo, Teresa M. V. D.. "Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies". ACS Omega 4 17 (2019): 17244-17250. http://dx.doi.org/10.1021/acsomega.9b01865.
    Published • 10.1021/acsomega.9b01865
  14. Nascimento, Bruno; Pereira, Nelson; Valente, Artur; Pinho e Melo, Teresa; Pineiro, Marta. "A Review on (Hydro)Porphyrin-Loaded Polymer Micelles: Interesting and Valuable Platforms for Enhanced Cancer Nanotheranostics". Pharmaceutics 11 2 (2019): 81. http://dx.doi.org/10.3390/pharmaceutics11020081.
    Open access • 10.3390/pharmaceutics11020081
  15. Pereira, Nelson A.M.; Laranjo, Mafalda; Pina, João; Oliveira, Andreia S.R.; Ferreira, João Dias; Sánchez-Sánchez, Carles; Casalta-Lopes, João; et al. "Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins". European Journal of Medicinal Chemistry 146 (2018): 395-408. http://dx.doi.org/10.1016/j.ejmech.2017.12.093.
    10.1016/j.ejmech.2017.12.093
  16. Pereira, Nelson A. M.; Laranjo, Mafalda; Casalta-Lopes, João; Serra, Arménio C.; Piñeiro, Marta; Pina, João; Seixas de Melo, J. Sérgio; et al. "Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents". ACS Medicinal Chemistry Letters 8 3 (2017): 310-315. http://dx.doi.org/10.1021/acsmedchemlett.6b00476.
    10.1021/acsmedchemlett.6b00476
  17. Pereira, Nelson A.M.; Laranjo, Mafalda; Pineiro, Marta; Serra, Arménio C.; Santos, Kathleen; Teixo, Ricardo; Abrantes, Ana Margarida; et al. "Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cells". European Journal of Medicinal Chemistry 103 (2015): 374-380. http://dx.doi.org/10.1016/j.ejmech.2015.08.059.
    10.1016/j.ejmech.2015.08.059
  18. Lopes, Susana M. M.; Correia, Cátia F. O.; Nunes, Sandra C. C.; Pereira, Nelson A. M.; Ferreira, Ana R. F.; Sousa, Emanuel P.; Gomes, Clara S. B.; et al. "Synthesis of chiral hexacyclic steroids via [8p + 2p] cycloaddition of diazafulvenium methides". Organic & Biomolecular Chemistry 13 34 (2015): 9127-9139. http://dx.doi.org/10.1039/c5ob01110h.
    10.1039/c5ob01110h
  19. Pereira, Nelson A. M.; Pinho e Melo, Teresa M. V. D.. "Recent Developments in the Synthesis of Dipyrromethanes. A Review". Organic Preparations and Procedures International 46 3 (2014): 183-213. http://dx.doi.org/10.1080/00304948.2014.903140.
    10.1080/00304948.2014.903140
  20. Lemos, Américo; Pinho e Melo, Teresa; Pereira, Nelson; Lopes, Susana. "On-Water Synthesis of Dipyrromethanes via Bis-Hetero-Diels–Alder Reaction of Azo- and Nitrosoalkenes with Pyrrole". Synlett 25 03 (2013): 423-427. http://dx.doi.org/10.1055/s-0033-1340300.
    10.1055/s-0033-1340300
  21. Pereira, Nelson A.M.; Lemos, Américo; Serra, Arménio C.; Pinho e Melo, Teresa M.V.D.. "Functionalization of dipyrromethanes via hetero-Diels–Alder reaction with azo- and nitrosoalkenes". Tetrahedron Letters 54 12 (2013): 1553-1557. http://dx.doi.org/10.1016/j.tetlet.2013.01.032.
    10.1016/j.tetlet.2013.01.032
  22. Pereira, Nelson A. M.; Fonseca, Sofia M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.; Burrows, Hugh D.. "[8p+2p] Cycloaddition of meso-Tetra- and 5,15-Diarylporphyrins: Synthesis and Photophysical Characterization of Stable Chlorins and Bacteriochlorins". European Journal of Organic Chemistry 2011 20-21 (2011): 3970-3979. http://dx.doi.org/10.1002/ejoc.201100465.
    10.1002/ejoc.201100465
  23. Pereira, Nelson A. M.; Serra, Arménio C.; Pinho e Melo, Teresa M. V. D.. "Novel Approach to Chlorins and Bacteriochlorins: [8p+2p] Cycloaddition of Diazafulvenium Methides with Porphyrins". European Journal of Organic Chemistry 2010 34 (2010): 6539-6543. http://dx.doi.org/10.1002/ejoc.201001157.
    10.1002/ejoc.201001157
  24. Pereira, Nelson; Serra, Arménio C.; Pineiro, Marta; Gonsalves, António M. d'A. Rocha; Abrantes, Margarida; Laranjo, Mafalda; Botelho, Filomena. "Synthetic porphyrins bearing ß-propionate chains as photosensitizers for photodynamic therapy". Journal of Porphyrins and Phthalocyanines 14 05 (2010): 438-445. http://dx.doi.org/10.1142/s1088424610002227.
    10.1142/s1088424610002227
  25. Serra, Arménio; Pineiro, Marta; Pereira, Nelson; Rocha Gonsalves, António; Laranjo, Mafalda; Abrantes, Margarida; Botelho, Filomena. "A look at clinical applications and developments of photodynamic therapy". Oncology Reviews 2 4 (2008): 235-249. http://dx.doi.org/10.1007/s12156-008-0081-1.
    10.1007/s12156-008-0081-1
Thesis / Dissertation
  1. Nelson A. M. Pereira. "Reacções de Ciclo-Adição na Síntese de Novos Dipirrometanos e Hidroporfirinas". PhD, Universidade de Coimbra, 2014.
  2. Nelson A. M. Pereira. "Síntese de Porfirinas beta-Subtituídas e Sua Aplicação em Terapia Fotodinâmica do Cancro". Master, Universidade de Coimbra, 2008.
  3. Nelson A. M. Pereira. "Determinação de acrilamida em águas naturais - desenvolvimento do método por cromatografia gasosa". Degree, Universidade de Coimbra, 2005.

Intellectual property

Patent
  1. Burrows, Hugh D.; Pinho e Melo, Teresa M. V. D.; Serra, Arménio C.; Pereira, Nelson A. M.; Martelo, Liliana; Piñeiro, Marta; Seixas de Melo, J. Sérgio; et al. 2017. "Ring-Fused Chlorins, Methods And Uses Thereof".
  2. Burrows, Hugh D.; Pinho e Melo, Teresa M. V. D.; Serra, Arménio C.; Pereira, Nelson A. M.; Martelo, Liliana; Piñeiro, Marta; Seixas de Melo, J. Sérgio; et al. 2017. "Clorinas Fundidas de Platina(II), seus Métodos e Usos". Portugal.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Platinum(II) ring-fused chlorin photosensitizers for cancer theranostic applications: synthesis, in vitro cell biology and in vivo proof of concept (Delivered by Bruno F. O. Nascimento) 13th National Meeting on Organic Chemistry/6th National Meeting on Medicinal Chemistry, Aveiro, Portugal (January 15-17, 2020)
(Aveiro, Portugal)
2019 Separação, Identificação e Citotoxicidade de Meios Condicionados Pelo Biomaterial Life (Delivered by Maria Beatriz Ferreira) 28º Congresso da Ordem dos Médicos Dentistas, Lisboa, Portugal (November 14-16, 2019)
(Lisboa, Portugal)
2018 Advances on Photodynamic Therapy of Cancer Through Novel Ring-Fused 5,15-Diphenylchlorins 12th Organic Chemistry/ 5th Therapeutic Portuguese National Meetings, Coimbra, Portugal, (January 17-19, 2018)
(Coimbra, Portugal)
2018 Synthesis and characterization of promising theranostic agents for cancer (Delivered by Márcia Campos) 6th Portuguese Young Chemists Meeting, Setúbal, Portugal, (May 15-18, 2018)
(Setúbal, Portugal)
2018 Promising nanobody-ring-fused chlorin conjugate as potential agent for targeted photodynamic therapy of cancer [selected poster for pitch presentation] Photodynamic Therapy and Photodiagnosis Update, Kochel am See, Germany (September 18-22, 2018)
( Kochel am See, Germany)
2017 Targeting Human Melanoma Cells with Novel 4,5,6,7-tetrahydropyrazolo[1,5a]pyridine-fused diphenylchlorins as new photosensitizers (Delivered by João Ferreira) XLVII Meeting of Pharmacology Portuguese Society, Coimbra, Portugal (February 2-4, 2017)
(Coimbra, Portugal)
2017 Cytotoxicity studies on novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused diphenylchlorins as photosensitizers in human melanoma cells (Delivered by João Ferreira) 8th AIMS Meeting Research Competition by Fundação AstraZeneca, Lisbon, Portugal (March 10-12, 2017)
(Lisbon, Portugal)
2014 Sensor Luminescente para a Detecção e Monitorização de Oxigénio (Delivered by Liliana Martelo) XX Luso-Galego Chemistry Meeting, Aveiro, Portugal, (November 26-28, 2014)
(Porto, Portugal)
2013 Novel Synthesis of Dipyrromethanes via Hetero-Diels-Alder Reaction of Azo- and Nitrosoalkenes with Pyrrole 10th Portuguese National Meeting of Organic Chemistry and the 1st Portuguese-Brazilian Organic Chemistry Symposium, Lisbon, Portugal, (September 4-6, 2013)
(Lisbon, Portugal)
2010 Synthesis of Chlorins and Bacteriochlorins via [8pi+2pi] Cycloaddition of Diazafulvenium Methides with Porphyrins XVI Luso-Galego Chemistry Meeting, Aveiro, Portugal, (November 10-12, 2010)
(Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2019 Isolation, identification and cytotoxicity of a direct pulp capping biomaterial
Co-supervisor
 Medicina Dentária (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2018 A New Generation of Ring-fused Fluorinated Chlorins as Promising PDT Agents
Co-supervisor of João Carlos Simões
 Química Medicinal (Master)
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/01/17 - 2018/01/19 12th National Organic Chemistry Meeting (12ENQO) and the 5th National Medicinal Chemistry Meeting (5ENQT), Coimbra, Portugal (2018/01/17 - 2018/01/19)
Conference (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Trans-A2B-Corroles are Superior Photosensitizers for Lung Cancer
(Thesis) Main arguer
 João Pedro Gomes de Oliveira Braz TRANS-A2B- (Master)
Universidade de Coimbra, Portugal
2019 Isolation, identification and cytotoxicity of a direct pulp capping biomaterial
Supervisor
 Maria Beatriz Batista Rodrigues Ferreira (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 Photophysical characterization and Biological Evaluation of Promising Theranostic Agents for Cancer
(Thesis) Main arguer
 Márcia Alexandra de Campos Aguiar (Master)
Universidade de Coimbra, Portugal

Association member

Society Organization name Role
2010 - Current Sociedade Portuguesa de Química (SPQ)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Práticas Laboratoriais de Química Orgânica (Organic Chemistry Laboratory Classes) Bioquímica (Licenciatura) Universidade de Coimbra, Portugal
2020 - Current Teórico-Práticas de Química Orgânica (Theoretical-Practical Classes in Organic Chemistry) Bioquímica (Licenciatura) Universidade de Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2020 - Current Pharmaceuticals (1424-8247) MDPI
2020 - Current Molecules (1420-3049) MDPI
2019 - Current Materials (1996-1944) MDPI

Mentoring / Tutoring

Topic Student name
2017 - 2021 Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine Fused Chlorins: a Novel Type of Photodynamic Agents for Cancer Therapy [project within the Medchemtrain PhD Program at the Organic Chemistry Group (Supervision in the lab)] Ana Isabel Mata
2018 - 2019 Novos Macrociclos Tetrapirrólicos de tipo Clorina como Agentes Fotossensibilizadores para Terapia Fotodinâmica de Cancro [Bachelor's degree final project of Chemistry (Supervision in lab)] Bruna Diana Paiva Costa
2016 - 2017 Química dos Azo- e Nitroso-alquenos na Síntese de compostos Tetrapirrólicos [Master’s degree final project of Chemistry, University of Coimbra (supervision in the lab)] Inês Catarina Fonseca
2014 - 2015 Clorinas e Bacterioclorina Fundidas com o Anel 4,5,6,7-Tetrahidropirazolo[1,5-A]Piridina como Novos Fotossensibilizadores para o Tratamento do Cancro [Master’s degree final project of Medicinal Chemistry, University of Coimbra (supervision in the lab)] Ana Rita Ferreira
2012 - 2013 Síntesis de Clorinas Y Bacterioclorinas: Cicloadiciones [8p + 2p] de Los Anión Metil 1,2-Diazafulvenios a Compuestos Porfirínicos Meso-Sustituídos [Erasmus master’s degree final project of Chemistry, University of Coimbra (supervision in the lab)] Carlos Sánchez Sánchez
2012 - 2013 Clorina fundida com o sistema 4,5,6,7-tetra-hidropirazolo[1,5-a]piridina como fotossensibilizador para o tratamento do cancro do melanoma [Bachelor’s degree final project of Medicinal Chemistry, University of Coimbra (supervision in the lab)] Ana Rita Ferreira
2012 - 2012 Síntese de derivados pirrólicos com origem no ácido clavulânico para aplicação no diagnóstico e terapia do cancro [Bachelor’s degree final project of Biochemistry, University of Coimbra (supervision in the lab)] José Rui Russo Simplício

Other jury / evaluation

Activity description Institution / Organization
2017 - 2017 Nuno A. Guerreiro Alves, Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine Fused Chlorins: a Novel Type of Photodynamic Agents for Cancer Therapy, Lab rotation project within the Medchemtrain PhD Program at the Organic Chemistry Group Universidade de Coimbra, Portugal
Distinctions

Award

2020 Portuguese Award for Best Master Thesis in Organic Chemistry 2019 (Co-supervision)
Sociedade Portuguesa de Química, Portugal

Other distinction

2009 PhD Studentship from FCT (SFRH/BD/61573/2009)
Fundação para a Ciência e a Tecnologia, Portugal