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Graça Baltazar is a biologist with a Ph.D. in Cellular Biology (2000) from the Faculty of Sciences and Technology (University of Coimbra), and a Master's degree in Cellular Biology, from the same University. She is an Associate Professor at the Faculty of Health Sciences, University of Beira Interior. Her research interests are focused on understanding the interactions between neurons and glial cells and targeting these interactions to minimize neurodegeneration and promote repair and recovery after brain injury. She is currently exploring the following research themes: The potential of stem cells as therapy for ischemic brain injuries. - Effects of electromagnetic stimulation on astrocytes and its impact on the function and survival of neuronal cells in ischemia models. - Role of striatal enriched protein tyrosine phosphatase (STEP) in controlling synapse formation and maturation. She is a member of the Scientific Board of the Faculty of Health Sciences and the Health Sciences Research Centre of the University of Beira Interior (CICS-UBI). She is also responsible for the animal facilities Faculty of Health Sciences and coordinator of the Organ responsible for the welfare of animals at this facility. She is the coordinator of the Ph.D. program in Biomedicine at UBI.
Identification

Personal identification

Full name
Graça Maria Fernandes Baltazar
Gender
Female

Citation names

  • Baltazar, Graça

Author identifiers

Ciência ID
0E18-691A-B240
ORCID iD
0000-0002-7942-0432

Email addresses

  • gbaltazar@fcsaude.ubi.pt (Professional)

Telephones

Telephone
  • 275329042 (Professional)

Addresses

  • Faculdade de Ciências da Saúde, Universidade da Beira Interior. Av. Infante D. Henrique, 6200-506, Covilhã, Covilhã, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
Education
Degree Classification
2000
Concluded
PhD in Biology (Doutoramento)
Major in Cellular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1995
Concluded
Master in Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1992
Concluded
Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2011/09/20 - Current Associate Professor (University Teacher) Universidade da Beira Interior, Portugal
2007 - 2011/09/19 Assistant Professor (University Teacher) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2002/07/01 - 2007/07/01 Invited Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
Projects

Grant

Designation Funders
2021/11/19 - Current Neonatal Hypoxic-Ischemic Encephalopathy: Stem Cell Therapy and Identification of Biomarkers for Early Diagnosis, Prognosis, and Prediction of Treatment Success
2021.07854.BD
Supervisor
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - Current The role of STEP in dopaminergic synapse function and dysfunction
SFRH/BD/135936/2018
Supervisor
Ongoing
2009 - Current Envolvimento dos receptores da dopamina na expressão de GDNF em resposta a uma lesão dopaminérgica
SFRH/BD/47311/2008
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded
2007 - Current Role of astrocytes in microglia modulation: involvement in the neuroprotective-neurotoxic microglia switch
SFRH/BD/15889/2005
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01 - Current CellPRIME
N/A
Principal investigator
Universidade da Beira Interior, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2022/03/01 - Current SAIN - Segesterone Acetate Intranasal Nanoemulsion
181231
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Ongoing
2017 - Current PPBI - Plataforma Portuguesa de BioImagem
POCI-01-0145-FEDER022122
Responsible for the node at the University of Beira Interior.
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2023/10/04 - 2026/11/30 REPAIR - Reparar e Recuperar no AVC isquémico: novas estratégias de terapia celular
PL23-00001
Co-Principal Investigator (Co-PI)
Fundação 'la Caixa'

Fundação para a Ciência e a Tecnologia
Ongoing
2020/11/01 - 2023/10/31 CICS4COVID - Testar, Rastrear, e Inovar no Diagnóstico da COVID-19
072541
Researcher
Ongoing
2021/11/01 - 2022/10/31 Intranasal Delivery of Simvastatin in Stroke
UIDP/Multi/00709/2020
Cco-Investigador responsável
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde
Ongoing
2018/07/01 - 2021/06/30 Combinação do Secretoma de Células Estaminais Mesenquimatosas (MSCs) e terapias farmacológicas para o tratamento da Doença de Parkinson
PTDC/MED-FAR/29751/2017
Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/09/01 - 2021/05/31 Novas abordagens em Encefalopatia hipóxico-isquémica: investigação translacional para diagnosticar e monitorizar resposta a terapia com células estaminais.
PTDC/BTM-TEC/29311/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade da Beira Interior, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/04 - 2020/12/31 ICON - Desafios interdisciplinares em Neurodegeneração
CENTRO-01-0145-FEDER-000013
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
European Regional Development Fund
Concluded
2013/05/01 - 2015/10/30 Modulação da reactividade microglial pelo GDNF: relevância para a protecção dopaminérgica
PTDC/NEU-BEN/0156/2012
Principal investigator
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/09/30 Mecanismos de protecção neuronal contra stress oxidativo mediados pela DJ-1: implicações na doença de Parkinson
PTDC/NEU-NMC/0205/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho, Portugal

Universidade da Beira Interior, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2015/07/31 MicroRNA-124 encapsulado em nanopartículas: promover a neurogénese para tratar a doença de Parkinson
EXPL/BIM-MED/0822/2013
Researcher
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Hormonal and Inflammatory basis of age-related diseases
CENTRO-07-ST24-FEDER-002015
European Regional Development Fund
2011/01/01 - 2013/12/31 Strategic Project - UI 709 - 2011-2012
PEst-C/SAU/UI0709/2011
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Acções troficas dos factores neurotróficos: dependência da co-activação de receptores A2A da adenosina
PTDC/SAU-NEU/64126/2006
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 Regulação dos níveis de TTR humana e de ratinho no fígado e plexo coroideu pelas hormonas esteróides
POCI/SAU-NEU/55380/2004
Researcher
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Baltazra, Graça. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". 2019.
    10.1007/978-1-4939-8946-1_13
  2. Duarte, E.P.; Saavedra, A.; Baltazar, G.. "GDNF: A key player in neuron-glia crosstalk and survival of nigrostriatal dopaminergic neurons". 2007.
    10.1007/978-0-387-70830-0_8
  3. Duarte, E.P.; Baltazar, G.; Veríssimo, P.; Carvalho, A.P.. "Release of catecholamines and enkephalin peptides induced by reversal of the Na+-Ca2+ exchanger in chromaffin cells". 1996.
Conference abstract
  1. Peres, Carina; Samile F. da Silva; Anabela Chiangalala; Meirinho, Sara; Susana Alves ferreira; Palmeira-de-Oliveira, Rita; Susana Palinhas; et al. "Intranasal Segesterone Acetate Nanoemulsion Development – Safety Evaluation". Paper presented in EUFEPS Annual meeting, May 31 – June 2 2023, Lisboa, 2023.
  2. Serrenho, Inês; Cardoso, Carla; Grãos, M; Manadas, Bruno; Baltazar, Graça. "Umbilical Cord Blood Cells And Therapeutic Hypothermia – A Promising Duo For The Treatment Of Neonatal Hypoxic-Ischemic Encephalopathy". Paper presented in XVI ANNUAL CICS-UBI SYMPOSIUM 2021, Covilhã, 2021.
Conference poster
  1. Silva, Ana A.; Fiadeiro, Mariana B.; LILIANA INÁCIO BERNARDINO; Baltazar, Graça; Cristóvão, Ana Clara. "NEUROINFLAMMATION MODULATION IN PARKINSON¿S DISEASE CONTEXT". Paper presented in IV International Congress in Health Science Research ¿ Challenges from Research to Clinics, 2023.
  2. Susana A. Ferreira; Nuno Pinto; Patto, Maria Vaz; Baltazar, Graça. "High-Frequency Repetitive Magnetic Stimulation Rescued Neurons Injured by Ischemia Through Modulation of GDNF Levels in Astrocytes". Paper presented in IV International Congress in Health Sciences Research towards innovation and enterpreneurship: Challenges from Research to Clinics, Covilhã, 12-15 de Fevereiro, 2023.
  3. Silva, Ana A.; Fiadeiro, Mariana B.; Baltazar, Graça; Cristóvão, Ana Clara. "NEUROINFLAMMATION MODULATION BY 5-AMINOSALICYLIC ACID". Paper presented in XVII International CICS-UBI Symposium, 2022.
  4. Susana A. Ferreira; Nuno Pinto; Patto, Maria Vaz; Baltazar, Graça. "Contribution of astrocytes to the neuroprotective effect mediated by rMS". Paper presented in XVII International CICS-UBI Symposium, Universidade da Beira Interior, Covilhã, 21-21 de Julho, 2022.
  5. Susana A. Ferreira; Nuno Pinto; Patto, Maria Vaz; Baltazar, Graça. "Neurons Injured by Ischemia can be Rescued Through the Modulation of Astrocytes by HF-rMS". Paper presented in VI Symposium of the Portuguese Glial Network, i3s, Porto, 18 de Outubro, 2022.
  6. Serrenho, Inês; Cardoso, Carla; Grãos, Mário; Manadas, Bruno; Baltazar, Graça. "Umbilical Cord Blood Cells and Therapeutic Hypothermia Leads to Functional Recovery in a Neonatal Hypoxic-Ischemic Encephalopathy Rodent Model". Paper presented in SPN 2021, 2021.
Journal article
  1. da Silva, Ana Alexandra Flores; Fiadeiro, Mariana Bernardo; Bernardino, Liliana Inácio; Fonseca, Carla Sofia Pais; Baltazar, Graça Maria Fernandes; Cristóvão, Ana Clara Braz. ""Lipopolysaccharide-induced animal models for neuroinflammation – An overview."". Journal of Neuroimmunology 387 (2024): 578273. http://dx.doi.org/10.1016/j.jneuroim.2023.578273.
    10.1016/j.jneuroim.2023.578273
  2. Ferreira, Susana A.; Pinto, Nuno; Serrenho, Inês; Pato, Maria Vaz; Baltazar, Graça. "Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation". Neural Regeneration Research 19 1 (2024): 116-123. http://dx.doi.org/10.4103/1673-5374.374140.
    10.4103/1673-5374.374140
  3. Mendes-Oliveira, Julieta; Campos, Filipa L.; Ferreira, Susana A.; Tomé, Diogo; Fonseca, Carla P.; Baltazar, Graça. "Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation". Cells 13 1 (2023): 74. http://dx.doi.org/10.3390/cells13010074.
    10.3390/cells13010074
  4. da Silva, Andreia Valente; Serrenho, Inês; Araújo, Beatriz; Carvalho, Alexandre Martins; Baltazar, Graça. "Secretome as a Tool to Treat Neurological Conditions: Are We Ready?". International Journal of Molecular Sciences 24 22 (2023): 16544. http://dx.doi.org/10.3390/ijms242216544.
    10.3390/ijms242216544
  5. Santa, Cátia; Rodrigues, Diana; Coelho, Joana F.; Anjo, Sandra I.; Mendes, Vera M.; Bessa-Neto, Diogo; Dunn, Michael J.; et al. "Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons". Translational Psychiatry 13 1 (2023): http://dx.doi.org/10.1038/s41398-023-02609-w.
    10.1038/s41398-023-02609-w
  6. Susana A. Ferreira; Nuno Pinto; Serrenho, Inês; Patto, Maria Vaz; Baltazar, Graça. "Contribution of glial cells to the neuroprotective effects triggered by rMS: a systematic review". Neural Regeneration Research (2023): http://dx.doi.org/10.4103/1673-5374.374140.
    Published
  7. Inês Serrenho; Carla Cardoso; Mário Grãos; alexandra dinis; Bruno Manadas; Graça Baltazar. "Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model". International Journal of Molecular Sciences 24 1 (2022): 257-257. http://dx.doi.org/10.3390/ijms24010257.
    10.3390/ijms24010257
  8. Genilso Gava-Junior; Susana A. Ferreira; Cláudio Roque; Julieta Mendes-Oliveira; Inês Serrenho; Nuno Pinto; Maria Vaz Patto; Graça Baltazar. "High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte's secretome". Journal of Neurochemistry (2022): https://doi.org/10.1111/jnc.15740.
    10.1111/jnc.15740
  9. Melissa Mariana; Claudio Roque; Graça Baltazar; Elisa Cairrao. "In Vitro Model for Ischemic Stroke: Functional Analysis of Vascular Smooth Muscle Cells". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01103-5.
    10.1007/s10571-021-01103-5
  10. Roque C; Pinto N; Vaz Patto M; Baltazar G. "Astrocytes contribute to the neuronal recovery promoted by high-frequency repetitive magnetic stimulation in in vitro models of ischemia.". Journal of neuroscience research (2021): http://europepmc.org/abstract/med/33522025.
    10.1002/jnr.24792
  11. Gava-Junior G; Roque C; Mendes-Oliveira J; Bernardino AC; Serrenho I; Pires JP; Baltazar G. "A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia.". Journal of visualized experiments : JoVE (2020): http://europepmc.org/abstract/med/33252110.
    10.3791/61388
  12. Baltazra, Graça. "A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson's disease potential biomarkers.". Translational neurodegeneration (2020): https://europepmc.org/articles/PMC7118951.
    10.1186/s40035-020-00188-0
  13. Campos, Jonas; Guerra-Gomes, Sónia; Serra, Sofia C.; Baltazar, Graça; Oliveira, João F.; Teixeira, Fábio G.; Salgado, António J.. "Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations". Brain Research 1732 (2020): 146700. http://dx.doi.org/10.1016/j.brainres.2020.146700.
    10.1016/j.brainres.2020.146700
  14. Patrícia Quelhas; Graça Baltazar; Elisa Cairrao. "The Neurovascular Unit: Focus on the Regulation of Arterial Smooth Muscle Cells". Current Neurovascular Research (2019): https://doi.org/10.2174/1567202616666191026122642.
    10.2174/1567202616666191026122642
  15. C. Roque; J. Mendes-Oliveira; C. Duarte-Chendo; G. Baltazar. "The role of G protein-coupled estrogen receptor 1 on neurological disorders". Frontiers in Neuroendocrinology (2019): https://doi.org/10.1016/j.yfrne.2019.100786.
    10.1016/j.yfrne.2019.100786
  16. Cláudio Roque; Julieta Mendes-Oliveira; Graça Baltazar. "G protein-coupled estrogen receptor activates cell type-specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes". Journal of Neurochemistry 149 1 (2019): 27-40. https://doi.org/10.1111/jnc.14648.
    10.1111/jnc.14648
  17. Mendes-Oliveira J; Lopes Campos F; Videira RA; Baltazar G. "GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment.". (2017): http://europepmc.org/abstract/med/28450223.
    10.1016/j.bbi.2017.04.016
  18. Roque C; Baltazar G. "Impact of Astrocytes on the Injury Induced by In Vitro Ischemia.". (2017): http://europepmc.org/abstract/med/28315110.
    10.1007/s10571-017-0483-3
  19. Tomé D; Fonseca CP; Campos FL; Baltazar G. "Role of Neurotrophic Factors in Parkinson´s Disease.". (2016): http://europepmc.org/abstract/med/27928963.
  20. Kurup, P.K.; Xu, J.; Videira, R.A.; Ononenyi, C.; Baltazar, G.; Lombroso, P.J.; Nairn, A.C.. "STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease". Proceedings of the National Academy of Sciences of the United States of America 112 4 (2015): 1202-1207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921725758&partnerID=MN8TOARS.
    10.1073/pnas.1417423112
  21. Esteves, M.; Cristóvão, A.C.; Saraiva, T.; Rocha, S.M.; Baltazar, G.; Ferreira, L.; Bernardino, L.. "Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for parkinson's disease". Frontiers in Aging Neuroscience 7 MAR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926392573&partnerID=MN8TOARS.
    10.3389/fnagi.2015.00020
  22. Bessa, A.; Campos, F.L.; Videira, R.A.; Mendes-Oliveira, J.; Bessa-Neto, D.; Baltazar, G.. "GPER: A new tool to protect dopaminergic neurons?". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 10 (2015): 2035-2041. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938151582&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.07.004
  23. Baltazra, Graça. "Analysis of Citalopram in Plasma and Hair by a Validated LC MS/MS Method". Journal of Chromatography & Separation Techniques (2015): http://dx.doi.org/10.4172/2157-7064.1000274.
    10.4172/2157-7064.1000274
  24. Rocha, S.M.; Pires, J.; Esteves, M.; Baltazar, G.; Bernardino, L.. "Histamine: A new immunomodulatory player in the neuron-glia crosstalk". Frontiers in Cellular Neuroscience 8 1 APR (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899699754&partnerID=MN8TOARS.
    10.3389/fncel.2014.00120
  25. Fonseca, C.P.; Gama, S.; Saavedra, A.; Baltazar, G.. "H2O2- or l-DOPA-injured dopaminergic neurons trigger the release of soluble mediators that up-regulate striatal GDNF through different signalling pathways". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 7 (2014): 927-934. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897372841&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.03.003
  26. Campos, F.L.; Carvalho, M.M.; Cristovão, A.C.; Je, G.; Baltazar, G.; Salgado, A.J.; Kim, Y.-S.; Sousa, N.. "Rodent models of Parkinson's disease: Beyond the motor symptomatology". Frontiers in Behavioral Neuroscience NOV (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84888382835&partnerID=MN8TOARS.
    10.3389/fnbeh.2013.00175
  27. Rocha, S.M.; Cristovão, A.C.; Campos, F.L.; Fonseca, C.P.; Baltazar, G.. "Astrocyte-derived GDNF is a potent inhibitor of microglial activation". Neurobiology of Disease 47 3 (2012): 407-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863442753&partnerID=MN8TOARS.
    10.1016/j.nbd.2012.04.014
  28. Campos, F.L.; Cristovão, A.C.; Rocha, S.M.; Fonseca, C.P.; Baltazar, G.. "GDNF Contributes to Oestrogen-Mediated Protection of Midbrain Dopaminergic Neurones". Journal of Neuroendocrinology 24 11 (2012): 1386-1397. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867668559&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2012.02348.x
  29. Ferreira, R.; Santos, T.; Gonçalves, J.; Baltazar, G.; Ferreira, L.; Agasse, F.; Bernardino, L.. "Histamine modulates microglia function". Journal of Neuroinflammation 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84860618694&partnerID=MN8TOARS.
    10.1186/1742-2094-9-90
  30. Cristóvão, A.C.; Saavedra, A.; Fonseca, C.P.; Campos, F.; Duarte, E.P.; Baltazar, G.. "Microglia of rat ventral midbrain recovers its resting state over time in vitro: Let microglia rest before work". Journal of Neuroscience Research 88 3 (2010): 552-562. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949143395&partnerID=MN8TOARS.
    10.1002/jnr.22219
  31. Heredia, A.; Bdikin, I.; Baltazar, G.; Kholkin, A.. "Ferroelectric Properties of Dried Rat Embryonic Neurons from the Substantia nigra by the Piezoresponse Force Microscopy". European Cells and Materials 20 SUPPL.3 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-84860891306&partnerID=MN8TOARS.
  32. Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A.. "17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway". Cellular and Molecular Neurobiology 29 4 (2009): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS.
    10.1007/s10571-008-9339-1
  33. Cristóvão, A.C.; Choi, D.-H.; Baltazar, G.; Beal, M.F.; Kim, Y.-S.. "The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death". Antioxidants and Redox Signaling 11 9 (2009): 2105-2118. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949200471&partnerID=MN8TOARS.
    10.1089/ars.2009.2459
  34. Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice". Journal of Molecular Neuroscience 38 1 (2009): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS.
    10.1007/s12031-008-9157-4
  35. Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A.. "5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway". Brain Research 1229 (2008): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS.
    10.1016/j.brainres.2008.06.095
  36. Saavedra, A.; Baltazar, G.; Duarte, E.P.. "Driving GDNF expression: The green and the red traffic lights". Progress in Neurobiology 86 3 (2008): 186-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-55049090172&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2008.09.006
  37. Gonçalves, I.; Quintela, T.; Baltazar, G.; Almeida, M.R.; Saraiva, M.J.M.; Santos, C.R.. "Transthyretin interacts with metallothionein 2". Biochemistry 47 8 (2008): 2244-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749120520&partnerID=MN8TOARS.
    10.1021/bi7016377
  38. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
  39. Saavedra, A.; Baltazar, G.; Duarte, E.P.. "Interleukin-1ß mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures". Neurobiology of Disease 25 1 (2007): 92-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751090113&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.08.019
  40. Saavedra, A.; Baltazar, G.; Santos, P.; Carvalho, C.M.; Duarte, E.P.. "Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: Role of neuron-glia crosstalk". Neurobiology of Disease 23 3 (2006): 533-542. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747186125&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.04.008
  41. Saavedra, A.; Baltazar, G.; Carvalho, C.M.; Duarte, E.P.. "GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures". Free Radical Biology and Medicine 39 12 (2005): 1611-1619. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844562650&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2005.08.005
  42. Baltazar, G.; Carvalho, A.P.; Duarte, E.P.. "Differential expression of syntaxin 1A and 1B by noradrenergic and adrenergic chromaffin cells". Neurochemical Research 28 10 (2003): 1453-1457. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141816760&partnerID=MN8TOARS.
    10.1023/A:1025658005937
  43. Baltazar G; Tomé A; Carvalho AP; Duarte EP; Baltazar, G.; Tomé, A.; Carvalho, A.P.; Duarte, E.P.. "Differential contribution of syntaxin 1 and SNAP-25 to secretion in noradrenergic and adrenergic chromaffin cells.". European Journal of Cell Biology 79 12 (2000): 883-891. http://europepmc.org/abstract/med/11152280.
    10.1078/0171-9335-00128
  44. Fonseca, C.P.; Montezinho, L.P.; Baltazar, G.; Layden, B.; Freitas, D.M.; Geraldes, C.F.G.C.; Castro, M.M.C.A.. "Li+ influx and binding, and Li+/Mg2+ competition in bovine chromaffin cell suspensions as studied by 7Li NMR and fluorescence spectroscopy". Metal-Based Drugs 7 6 (2000): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034445829&partnerID=MN8TOARS.
  45. Amari, L.; Layden, B.; Nikolakopoulos, J.; Rong, Q.; De Freitas, D.M.; Baltazar, G.; Castro, M.M.C.A.; Geraldes, C.F.G.C.. "Competition between Li+ and Mg2+ in neuroblastoma SH-SY5Y cells: A fluorescence and 31P NMR study". Biophysical Journal 76 6 (1999): 2934-2942. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032586726&partnerID=MN8TOARS.
  46. Baltazar, G.; Ladeira, I.; Carvalho, A.P.; Duarte, E.P.. "Two types of ¿-agatoxin IVA-sensitive Ca2+ channels are coupled to adrenaline and noradrenaline release in bovine adrenal chromaffin cells". Pflugers Archiv European Journal of Physiology 434 5 (1997): 592-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030841281&partnerID=MN8TOARS.
    10.1007/s004240050441
  47. Duarte, E.P.; Baltazar, G.; Carvalho, A.P.. "Differential stimulation of noradrenaline release by reversal of the Na+/Ca2+ exchanger and depolarization in chromaffin cells". European Journal of Neuroscience 6 7 (1994): 1128-1135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028321821&partnerID=MN8TOARS.
    10.1111/j.1460-9568.1994.tb00610.x

Other

Other output
  1. Development of safe micro and nanoemulsions for nose-to-brain delivery of the neuroprotective drug Nestorone. Oral Communication - IV International Congress in Health Science Research – Challenges from Research to Clinics. 2023. Peres, Carina; Samille F. da Silva; Meirinho, Sara; Susana A. Ferreira; Rodrigues, Márcio; Alves, Gilberto; Baltazar, Graça; SANTOS, ADRIANA O..
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/10 - Current Modulating MSCs to Maximize its Therapeutic Efficacy in Ischemic Stroke
Supervisor
Biomedicine (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/11/19 - Current Neonatal Hypoxic-Ischemic Encephalopathy: Stem Cell Therapy and Identification of Biomarkers for Early Diagnosis, Prognosis, and Prediction of Treatment Success
Supervisor
Biomedicine (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/09 - 2023/11/23 Administration of Mscs Secretome as a Therapeutic Strategy for Neonatal Hypoxic Ischemic Encephalopathy
Supervisor
Biomedical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/09 - 2023/11/22 Impact of Donor Variability in the Therapeutic Potential of Mesenchymal Stem Cells in An Animal Model of Hypoxic-Ischemic Encephalopathy
Supervisor
Biochemistry (Master)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2022/09 - 2023/11 Avaliação do Potencial Protetor do Acetato de Segesterona e da Sinvastatina em Um Modelo in Vitro de Isquemia Cerebral
Supervisor of Anabela Chiangalala
Biomedical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/09 - 2023/09/14 Mecanismos de Ação do Recetor de Estrogénios Acoplado a Proteína G (Gper) Nas Células Gliais.
Supervisor
Integrated master's degree in pharmaceutical sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/10 - 2023/07/13 Intraoperative 3d Fluoroscopy Accurately Predicts Correct Electrode Location in Deep Brain Stimulation Surgery
Co-supervisor
Integrated Master in Medicine (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/09 - 2023/07/06 Intranasal Administration of Mesenchymal Stem Cells in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy
Supervisor
Biomedical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/10 - 2022/10/27 Impact of High Frequency Repetitive Magnetic Stimulation on Astrocytes Subjected to Ischemia
Supervisor
Biomedical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/09 - 2022/07/20 Impact of Stem Cell Therapy in the Functional Alterations Present in Animal Model of Hypoxic Ischemic Encephalopathy
Supervisor
Biomedical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/10 - 2022/07/19 Impacto de Exercício Físico em Meio Aquático nos Sintomas e Qualidade de Vida de Pessoas com Doença de Parkinson
Supervisor
Medicine (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/09 - 2022/04/08 Papel do Recetor de Estrogénios Acoplado à Proteína G (Gper) na Proliferação e Sobrevivência de Uma Linha Celular de Glioma Humano
Supervisor
Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/09 - 2022/03/16 Efeito do Exercício Físico na Qualidade do Sono e Insónia
Supervisor
Medicine (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2020/10/01 - 2021/07/13 Estudo dos Efeitos dos Aditivos Di(2-Etilhexil) Ftalato e Metilparabeno Em Astrócitos Corticais.
Supervisor
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2019/10/01 - 2020/10/22 Effects of High Frequency Repetitive Magnetic Stimulation On Astrocytes In An Ischemic Cell Model
Supervisor
Segundo Ciclo em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2019/10/01 - 2020/10/19 Evaluation of The Antioxidant Action of The G Protein-Coupled Estrogen Receptor: Contribution To The Neuroprotective Actions of The Receptor
Supervisor
Segundo Ciclo em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2015 - 2020/07/02 Role of astrocytes in an in vitro model of ischemic stroke
Supervisor
Biomedicine (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018/11/01 - 2019/11/15 Role of Step In Dopaminergic Synapses
Supervisor
Mestrado Integrado em Bioquímica (Master)
Universidade da Beira Interior, Portugal
2019 - 2019 The role of STEP in dopaminenergic synapse function and dysfunction
Supervisor
Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2019 - 2019 Potencial dos Mediadores Inflamatórios como Biomarcadores na Doença de Alzheimer Experiência Profissionalizante na vertente de Farmácia Comunitária e Investigação
Supervisor
Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2019 - 2019 O segundo cérebro: da microbiota entérica à saúde cerebral
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2019 - 2019 Food addiction: An analysis of the relationship between obesity, over-eating and addiction behaviours
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2019 - 2019 Role of STEP in dopaminergic synapses
Supervisor
Bioquímica (Master)
Universidade da Beira Interior, Portugal
2018 - 2018 Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in the control of microglial
Supervisor
Bioquímica (Master)
Universidade da Beira Interior, Portugal
2018 - 2018 Avaliação da cognição e atividades da vida diária de utentes de Estruturas Residenciais para Pessoas Idosas da Covilhã e Belmonte
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Avaliação da resposta neurogénica à ativação do recetor de estradiol acoplado à proteína G (GPER)
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Potencial Terapêutico do Exercício Físico na Doença de Parkinson
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Stress Oxidativo e Doença de Parkinson
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Desenvolvimento de transportadores neuroprotetores derivados de macrociclos permeáveis à barreira hematoencefálica
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 A música como terapia adjuvante no tratamento da doença de Parkinson
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Perspetivas atuais sobre a associação entre demência e diabetes
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Papel do exercício físico na prevenção do défice cognitivo e da demência: o que sabemos sobre o tema?
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Promoting Nigrostriatal Protection through the Intranasal Delivery of a GPER Agonist
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 Modulation of Microglial Activity by GDNF
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 Análise do Papel Neuroprotetor da Proteína DJ-1 na Doença de Parkinson
Supervisor
Bioquímica (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Role of astrocytes in an in vitro model of ischemic stroke
Supervisor
Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2014 - 2014 Establishment of a method to evaluate the plasticity and maturation of the dopaminergic nerve terminal
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Regulation of DJ-1 Expression by Neuron-Astrocyte Interaction
Supervisor
Bioquímica (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Caracterização das abordagens farmacológicas usadas no tratamento das demências – análise de casos do CHCB Experiência Profissionalizante na vertente de Farmácia Comunitária, Farmácia Hospitalar e Investigação
Supervisor
Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 A Vitamina E na Doença de Alzheimer Uma perspectiva epidemiológica e clínica
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Clinical Characterization of Parkinson s Disease Patients Followed at CHCB Comparison with a control group
Supervisor
Medicina (Master)
Universidade da Beira Interior, Portugal
2013 - 2013 GDNF e GPER: novas ferramentas no controlo da neuroinflamação?
Supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2006 - 2006 Nadph Oxidase 1: a Key Player in Paraquat Induced Toxicity in Parkinson´s Disease
Supervisor
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2018 Finding new secretomes for Parkinson´s Disease Regenerative Medicine Applications.
(Thesis) Main arguer
Ana Verónica Mendes Domingues (Master)
Universidade do Minho, Portugal
2016  Mesenchymal stem cells secretome in Parkinson’s disease regenerative medicine
(Thesis) Main arguer
Bárbara Filipa Mendes Pinheiro (Master)
Universidade do Minho, Portugal
2016 Modulação da inflamação e da neurogénese no hipocampo: desvendar uma nova interação entre a histamina e o lipopolissacarídeo
(Thesis) Main arguer
SANDRA RAQUEL PINTO BARATA ANTUNES (Master)
Universidade da Beira Interior, Portugal
2015 The role of ageing in polyglutamine-induced neurodegeneration. A Study in Machado -joseph disease models;
(Thesis) Main arguer
Dina Maria da Silva Rodrigues Pereira (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 Mecanismos de protecção neuronal contra stress oxidativo mediados pela DJ-1: implicações na doença de Parkinson
(Thesis) Arguer
Sandra Isabel dos Santos Anjo (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 Modulação da função dos receptores dos produtos de glicação avançada na doença de Parkinson
(Thesis) Main arguer
Sofia Andreia Domingues Viana (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012 Purines control Neuron-Glia interaction during Neuroinflamation;
(Thesis) Main arguer
Jimmy George (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2012 Dissecting the crosstalk between stress, depression and obesity
(Thesis) Main arguer
Shilan Aslani (PhD)
Universidade do Minho, Portugal
2011 From Parkinson´s disease to dopamine dysregulation syndrome and impluse control disorders: the balance of dopamine in brain function and behavior
(Thesis) Arguer
Miguel Maria Vinha Murteira de Carvalho (PhD)
Universidade do Minho, Portugal
2011 Exploring the Secretome of Mesenchymal Like Stem Cells for Central Nervous System Regenerative Medicine: A Focus on Parkinson´s Disease
(Thesis) Main arguer
Ana de Oliveira Resende Pires Marques (PhD)
Universidade do Minho, Portugal

Committee member

Activity description
Role
Institution / Organization
2023/12 - Current Member of the Pedagogical Council of the Faculty of Health Sciences, University of Beira Interior
Member
2021/07 - Current Director of the PhD programme in Biomedicine
Director
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018/09/25 - Current Member of the Ethics Committee of the University of Beira Interior
President / Vice-president
Universidade da Beira Interior, Portugal
2018/09/07 - Current Member of the Course Committee for the 3rd cycle in Biomedicine, Faculty of Health Sciences, University of Beira Interior.
Director
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018/04/10 - Current Member of the Animal Welfare Board (ORBEA) of the Animal Facility of the Faculty of Health Sciences of the University of Beira Interior
Coordinator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/10/30 - Current member of the Course Committee for the Second Cycle in Biochemistry at the University of Beira Interior.
Member
2002 - Current Member of the Scientific Council
Member
2019/11/06 - 2021/12 Vice-coordinator of the Health Sciences Research Center
Other
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020 - 2021 Group leader "Neurologic and Neurovascular Disorders"
Coordinator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2014 - Current Grant Reviewer for: European Research Council; Medical Research Council (UK); Parkinsons UK; The Cure Parkinson's Trust (UK); Parkinson's Disease Society (UK); ARSLA (France); Fundação para a Ciência e a Tecnologia (Portugal); Agência Nacional de Inovação
Evaluator
2004 - Current Adhoc reviewer for the following journals (part III): Journal of Steroid Biochemistry and Molecular Biology; Journal of Translational Medicine; Molecular Neurobiology; Neural Plasticity; Neural Regeneration; Neural Regeneration Research; Neurobiology of Disease; Neurochemistry; Neuroendocrinology; Neuroimmunology; Neuroinflammation; Neurological Research; Neuropharmacology; Neuroscience; Neuroscience Journal; Neurotoxicity Research; Oxidative Medicine and Cellular Longevity; PLOS ONE; Reviews in the Neurosciences; Rejuvenation Research
Evaluator
2004 - Current Adhoc reviewer for the following journals (part I): Acta Neuropathologica; Antioxidants; ACS Chemical Neuroscience; Biochemistry and Molecular; Biology; Biomedicine & Pharmacotherapy; Brain, Behavior, and Immunity; Cell Calcium; Cellular Longevity; Cellular Physiology and Biochemistry; Free Radical Biology and Medicine; International Journal of Neuroscience; Journal of Neurochemistry; Journal of Neuroendocrinology; Journal of Neuroimmunology; Journal of Neuroinflammation; Journal of Neuroscience Methods
Evaluator
2004 - Current Adhoc reviewer for the following journals (part II): Scientific reports; Stem Cells International The International Journal of Molecular Sciences; The Journal of Steroid Biochemistry and Molecular Biology
Evaluator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal