???global.info.a_carregar???
Diogo Santos completed the integrated master’s in biomedical engineering from the University of Minho in 2021 where he is currently a PhD student. His main research interests are in the field of central nervous system regenerative medicine, specifically in studying the impact of stem cell secretome in spinal cord injury. Over the last years he has gained experience with cell culture, secretome proteomic analysis, in vitro and in vivo models of central nervous system trauma, immunohistochemistry, protein engineering and microscopy. In his current PhD project, he is engineering the extracellular vesicles from mesenchymal stem cells for better targeting to the spinal cord injury site. He has published 6 articles, presented 2 oral communications and 7 conference posters, and he has been part of the organizing committee of the 12th International Meeting of the Portuguese Society of Stem Cells and Cell Therapies.
Read full resume ↓
Identification

Personal identification

Full name
Diogo Jorge Ferreira Santos

Citation names

  • Santos, Diogo J

Author identifiers

Ciência ID
0C1E-250F-8313
ORCID iD
0000-0002-0900-2278

Email addresses

  • a77974@alunos.uminho.pt (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Proficiency (C2)
Education
Degree Classification
2022/10/01 - 2026/10/01
Ongoing
 Programa de Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
"Genetic engineering of the CD81 large extracellular loop for targeted delivery of mesenchymal stem cell derived vesicles for spinal cord injury repair" (THESIS/DISSERTATION)
2022/02/14 - 2022/02/25
Concluded
 Animal science course - FELASA C Accreditation equivalent (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/09/01 - 2021/03/24
Concluded
 Integrated Master's in Biomedical Engineering (Mestrado integrado)
Major in Clinical Engineering
Universidade do Minho Escola de Engenharia, Portugal
"Impact of the Secretome of Induced Mesenchymal Stem Cells in Axonal Growth and Spinal Cord Injury Repair" (THESIS/DISSERTATION)
 15
2020/04/02 - 2020/04/06
Concluded
 Recent Trends in CNS regenerative Medicine (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2021/03/15 - 2022/09/14 Diamond Photonics Platforms for Synaptic Connectivity Assessment in Healthy and Parkinson Disease Neuronal Models
LCF/PR/HR20/00249
Master Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Caixa d'Estalvis i Pensions de Barcelona
Ongoing
Outputs

Publications

Conference poster
  1. Santos, Diogo J; David Hercher; Katharina Stadlbauer; Gordana Wozniak-Knopp; Johannes Grillari; Salgado, António J.. Corresponding author: Salgado, António J.. "Genetic engineering of the CD81 large extracellular loop for targeted delivery of mesenchymal stem cell derived vesicles for spinal cord injury repair". Paper presented in 11th TERMIS Winterschool, 2024.
  2. Santos, Diogo J; David Hercher; Katharina Stadlbauer; Gordana Wozniak-Knopp; Johannes Grillari; Salgado, António J. (7A1F-809B-EC3F. Corresponding author: Salgado, António J. (7A1F-809B-EC3F. "Genetic engineering of the CD81 large extracellular loop for targeted delivery of mesenchymal stem cell derived vesicles for spinal cord injury repair". Paper presented in LBG Meeting Innovation in Health Sciences, 2023.
  3. Santos, Diogo J; David Hercher; Gordana Wozniak-Knopp; Johannes Grillari; Salgado, Antonio J.. Corresponding author: Salgado, Antonio J.. "Genetic engineering of the CD81 large extracellular loop for targeted delivery of mesenchymal stem cell derived vesicles for spinal cord injury repair". Paper presented in Small New World 2.0, 2023.
  4. Marote, Ana; Santos, Diogo J; Mendes-Pinheiro, Bárbara; Serre-Miranda, Cláudia; Filipa Antunes; Campos, Jonas; Sandra I. Anjo; et al. Corresponding author: Marote, Ana. "Cellular Aging Secretes: A Comparison Of Bone Marrow Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long Term Culture". Paper presented in International Society for Cell & Gene Therapy - 2023, 2023.
  5. Lentilhas-Graça, José ; Afonso, João L.; Santos, Diogo J; Eduardo Gomes; Lima, Rui; Andreia Pinho; de Sousa, Nídia; et al. Corresponding author: Nuno A. Silva. "Studying the therapeutic effect of the activated spleen macrophages secretome on spinal cord injury repair". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  6. Marote, Ana; Santos, Diogo J; Mendes-Pinheiro, Bárbara; Serre-Miranda, Cláudia ; Filipa Antunes; Campos, Jonas; Sandra I. Anjo; et al. Corresponding author: Salgado, António J.. "Induced mesenchymal stem cells as a secretome source for CNS regenerative therapies: similar secretory profile but decreased replicative senescence compared to bone marrow mesenchymal stem cells". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  7. Miguel Ribeiro; Santos, Diogo J; Marote, Ana; Canto-Gomes, João; Serre-Miranda, Cláudia ; Ricardo Araújo; Cláudia Alves; et al. Corresponding author: António J. Salgado. "Expansion of iPSC-derived human Mesenchymal Stem Cells using a human platelet lysate (hPL) as growth medium supplement". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  8. de Sousa, Nídia; Pinho, A.G; Monteiro, Susana; Liberato, Valentina; Santos, Diogo J; Salgado, Antonio. Corresponding author: Salgado, Antonio. "Acute administration of Baclofen after spinal cord injury improves locomotor behavior, bladder control and modulates the inflammatory response". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  9. Afonso, João L.; Rocha, Luís A.; Silva, Deolinda; Santos, Diogo J; Campos, Jonas; Gomes, Eduardo; Silva, Nuno A.; Salgado, António J.. Corresponding author: Salgado, António J.. "Interplay between adipose-derived stem cells and inflammatory mediators: impact on neurite outgrowth and vascular morphogenesis". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  10. Santos, Diogo J; Marote, Ana; Rocha, Luís; de Sousa, Nídia; Mendes-Pinheiro, Bárbara; Andreia Pinho; Monteiro, Susana; et al. Corresponding author: Salgado, Antonio J.. "Impact of the Secretome of Induced Mesenchymal Stem Cells in Axonal Growth and Spinal Cord Injury Repair". Paper presented in NeRD Meeting, 2020.
  11. Santos, Diogo J; Marote, Ana; Rocha, Luís A.; Salgado, António J.. Corresponding author: Salgado, António J.. "Impact of the Secretome of Induced Mesenchymal Stem Cells in Axonal Growth and Spinal Cord Injury Repair". Paper presented in NeRD Meeting, 2019.
Journal article
  1. Lentilhas-Graça, José; Santos, Diogo J; Afonso, João; Monteiro, Andreia; Pinho, Andreia G.; Mendes, Vera M.; Dias, Marta S.; et al. Corresponding author: Silva, Nuno A.. "The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol". Frontiers in Immunology 15 (2024): http://dx.doi.org/10.3389/fimmu.2024.1354479.
    10.3389/fimmu.2024.1354479
  2. Nidia de Sousa; Diego Robledo; Laura González-Llera; Andreia G. Pinho; Diogo J. Santos; Susana Monteiro; Jonas Campos; et al. "Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury". Data in Brief (2022): https://doi.org/10.1016/j.dib.2022.108809.
    10.1016/j.dib.2022.108809
  3. Marote, Ana; Santos, Diogo; Mendes-Pinheiro, Bárbara; Serre-Miranda, Cláudia; Anjo, Sandra I.; Vieira, Joana; Ferreira-Antunes, Filipa; et al. "Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture". Stem Cell Reviews and Reports (2022): http://dx.doi.org/10.1007/s12015-022-10453-6.
    10.1007/s12015-022-10453-6
  4. Nídia de Sousa; Andreia G. Pinho; Susana Monteiro; Valentina Liberato; Diogo J. Santos; Jonas Campos; Jorge R. Cibrão; et al. "Acute Baclofen administration promotes functional recovery after spinal cord injury". The Spine Journal (2022): https://doi.org/10.1016/j.spinee.2022.09.007.
    10.1016/j.spinee.2022.09.007
  5. de Sousa, Nídia; Santos, Diogo; Monteiro, Susana; Silva, Nuno; Barreiro-Iglesias, Antón; Salgado, António J.. "Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury". Journal of Neurotrauma 39 3-4 (2022): 249-258. http://dx.doi.org/10.1089/neu.2020.7591.
    10.1089/neu.2020.7591
  6. Mendes-Pinheiro, Bárbara; Soares-Cunha, Carina; Marote, Ana; Loureiro-Campos, Eduardo; Campos, Jonas; Barata-Antunes, Sandra; Monteiro-Fernandes, Daniela; et al. Corresponding author: José Salgado, António. "Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response". International Journal of Molecular Sciences 22 21 (2021): 11530. http://dx.doi.org/10.3390/ijms222111530.
    Open access • 10.3390/ijms222111530
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/03/10 - 2022/03/11 Member of the organizing committee for the 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2022/03/10 - 2022/03/11)
Meeting (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/02 - Current Meeting of the Austrian Cluster for Tissue Regeneration
Meeting
 Meeting of the Austrian Cluster for Tissue Regeneration
2021/11/30 - 2021/11/30 Participation in the V Symposium of the Portuguese Glial Network
Meeting
 V Symposium of the Portuguese Glial Network
Universidade de Coimbra, Portugal
2019/07/15 - 2019/07/15 Congress to discuss the most recent advances within the spinal cord injury field and their possible translation to clinical practice
Congress
 Minho Meeting on Spinal Cord Injury
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Distinctions

Award

2023 Poster award at the Small New Word 2.0 (Graz, Austria, 2023) conference
Austrian Society for Extracellular Vesicles (ASEV), Austria