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Identification

Personal identification

Full name
Henrique Pedro Pereira da Silva Amaral Machado

Citation names

  • Machado, Henrique

Author identifiers

Ciência ID
0918-3F5F-D194
ORCID iD
0000-0001-6188-2535

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2017 - 2022
Concluded
Ciências Biomédicas (Doutoramento)
Major in Microbiologia e Parasitologia
Universidade de Lisboa Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
"Impact of adipose tissue colonization by Trypanosoma brucei during infection" (THESIS/DISSERTATION)
2013 - 2015
Concluded
Ciências da Saúde (Mestrado)
Major in Microbiologia e Infeção
Universidade do Minho, Portugal
"The mechanisms underlying Mycobacterium Tuberculosis Virulence granted by the NRP gene" (THESIS/DISSERTATION)
18
2010 - 2013
Concluded
Bioquímica (Licenciatura)
Universidade do Minho, Portugal
15
Affiliation

Science

Category
Host institution
Employer
2024/11/04 - Current Invited Auxiliary Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Laboratório Associado ICVS 3B's, Portugal
2023/01 - 2023/10 Postdoc (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2021/01 - 2022/12 Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2017/01 - 2020/12 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
(...)
2016/07 - 2016/12 Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2015/11 - 2016/05 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2024/11 - Current In vitro screening-based selection and in vivo efficacy evaluation of bacteriophages as potential new assets in the topical treatment of Buruli Ulcer disease.
TC309
Researcher
GlaxoSmithKline España, Spain
GlaxoSmithKline España
2021/01 - 2023/10 Exploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease
FatTryp
Researcher
Gulbenkian Institute for Molecular Medicine, Portugal
European Research Council
Ongoing
2023/06 - 2023/09 Mechanism and function of epitranscriptomic poly(A) tail modifications in African trypanosomes (TrypM6A)
LA CAIXA - TRYPM6A - HR20-00361 - LFIGUEIREDO
Researcher
Gulbenkian Institute for Molecular Medicine, Portugal
Caixabank SA
2017/01 - 2020/12 Impact of adipose tissue colonization by Trypanosoma brucei during infection
PD/BD/128286/ 2017
PhD Student Fellow
Gulbenkian Institute for Molecular Medicine, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/11 - 2016/05 Prevention and control of tuberculosis in vulnerable populations of an urban centre in Northern Portugal
000138DT1
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
EEA Grants
Concluded
Outputs

Publications

Conference poster
  1. Machado, Henrique; Figueiredo, Luisa M.. "Loss of fat mass during a Trypanosoma brucei infection prolongs host survival". Paper presented in Molecular Parasitology Meeting XXXI, held virtually., 2020.
  2. Machado, Henrique; Figueiredo, Luisa M.. "Activation of lipolysis in the adipose tissue during a Trypanosoma brucei infection prolongs host survival". Paper presented in CAML XIII PhD Students Annual Meeting, held in Lisbon, Portugal, 2019.
  3. Machado, Henrique; Figueiredo, Luisa M.. "Trypanosoma brucei infection increases lipolysis in the adipose tissue". Paper presented in Gordon Research Conference: Biology of Host-Parasite Interactions, held in Newport, Rhode Island, USA, 2018.
  4. Machado, Henrique; Figueiredo, Luisa M.. "Trypanosoma brucei infection increases lipolysis in the adipose tissue". Paper presented in TwinntoInfect Spring School, held in Sesimbra, Portugal, 2018.
  5. Machado, Henrique; Figueiredo, Luisa M.. "Trypanosoma brucei mouse infection induces adipose tissue lipolysis". Paper presented in CAML XII PhD Students Annual Meeting, held in Lisbon, Portugal, 2018.
  6. Machado, Henrique. "The Mycobacterium tuberculosis non-ribosomal peptide synthase NRP: a novel player in host-pathogen interactions". Paper presented in XLI annual meeting of the Portuguese Society for Immunology, held in Braga, Portugal, 2015.
  7. Machado, Henrique. "Molecular characterization of Mycobacterium tuberculosis phylogenetic lineages in a group of low risk tuberculosis patients from the north of Portugal". Paper presented in XL annual meeting of the Portuguese Society for Immunology, held in Lisbon, Portugal, 2014.
Journal article
  1. Serra, Lúcia; Silva Pereira, Sara; Viegas, Idálio J.; Machado, Henrique; López-Escobar, Lara; Figueiredo, Luisa M.. Corresponding author: Figueiredo, Luisa M.. "m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle". Biomedical Journal (2024): 100728. http://dx.doi.org/10.1016/j.bj.2024.100728.
    10.1016/j.bj.2024.100728
  2. Machado, Henrique; Temudo, António; Niz, Mariana De. Corresponding author: Niz, Mariana De. "The lymphatic system favours survival of a unique T. brucei population". Biology Open 12 11 (2023): http://dx.doi.org/10.1242/bio.059992.
    10.1242/bio.059992
  3. Machado, Henrique; Hofer, Peter; Zechner, Rudolf; Smith, Terry K.; Figueiredo, Luísa M.. Corresponding author: Figueiredo, Luísa M.. "Adipocyte lipolysis protects mice against Trypanosoma brucei infection". Nature Microbiology 8 11 (2023): 2020-2032. http://dx.doi.org/10.1038/s41564-023-01496-7.
    10.1038/s41564-023-01496-7
  4. Machado, Henrique; Bizarra-Rebelo, Tiago; Costa-Sequeira, Mariana; Trindade, Sandra; Carvalho, Tânia; Rijo-Ferreira, Filipa; Rentroia-Pacheco, Barbara; Serre, Karine; Figueiredo, Luisa M.. "Trypanosoma brucei triggers a broad immune response in the adipose tissue". PLOS Pathogens 17 9 (2021): e1009933. http://dx.doi.org/10.1371/journal.ppat.1009933.
    10.1371/journal.ppat.1009933
  5. Machado, Henrique; Figueiredo, Luisa M.. "Polyreactive Antibodies Bridge Immunity Particles to Pathogen". Trends in Parasitology 36 10 (2020): 804-806. http://dx.doi.org/10.1016/j.pt.2020.07.012.
    10.1016/j.pt.2020.07.012
  6. Sousa, Jeremy; Cá, Baltazar; Maceiras, Ana Raquel; Simões-Costa, Luisa; Fonseca, Kaori L.; Fernandes, Ana Isabel; Ramos, Angélica; et al. "Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-15832-6.
    10.1038/s41467-020-15832-6
  7. Bhatt, Kiranmai; Machado, Henrique; Osório, Nuno S.; Sousa, Jeremy; Cardoso, Filipa; Magalhães, Carlos; Chen, Bing; et al. "A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis". mSphere 3 5 (2018): http://dx.doi.org/10.1128/msphere.00352-18.
    10.1128/msphere.00352-18
  8. Rito, Teresa; Matos, Carlos; Carvalho, Carlos; Machado, Henrique; Rodrigues, Gabriela; Oliveira, Olena; Ferreira, Eduarda; et al. "A complex scenario of tuberculosis transmission is revealed through genetic and epidemiological surveys in Porto". BMC Infectious Diseases 18 1 (2018): http://dx.doi.org/10.1186/s12879-018-2968-1.
    10.1186/s12879-018-2968-1
  9. Moreira-Teixeira, Lúcia; Sousa, Jeremy; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, Flávia; et al. "Type I IFN Inhibits Alternative Macrophage Activation duringMycobacterium tuberculosisInfection and Leads to Enhanced Protection in the Absence of IFN-¿ Signaling". The Journal of Immunology 197 12 (2016): 4714-4726. http://dx.doi.org/10.4049/jimmunol.1600584.
    10.4049/jimmunol.1600584
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 How trypanosomes tell fat to get lost 9th Kinetoplastid Molecular Cell Biology Meeting
(Woods Hole, United States)
2021 Impact of adipose tissue lipolysis during Trypanosoma brucei infection XIV CAML · IV NeurULisboa PhD Students Virtual Meeting
Faculty of Medicine, University of Lisbon (Lisbon, Portugal)
2017 Impact of adipose tissue colonization by Trypanosoma brucei during infection CAML XI PhD Students Annual Meeting
Faculty of Medicine, University of Lisbon (Lisbon, Portugal)
2015 The Mycobacterium tuberculosis non-ribosomal peptide synthase nrp modulates the host immune response and is required for optimal colonization UMIB summit 2015
Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/09 - 2022/01 Adipocyte metabolic response to Trypanosoma brucei In a co-culture setting
Co-supervisor
Masters Degree in Medical Microbiology (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018 - 2019 Organizing Committee of "XIII CAML PhD Students' Meeting, an annual meeting" where PhD students affiliated to the Faculty of Medicine of the University of Lisbon present their work and attend lecture from renowned invited speakers. (2019)
Conference (Member of the Organising Committee)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2017 Organizing Committee of the "10th iMM/CAML PhD retreat", an informal out of campus gathering of PhD students and other members of the local academic community to foster friendly relations and share ideas. (2017)
Other (Member of the Organising Committee)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2015 "XLI annual meeting of the Portuguese Society for Immunology" (2015)
Meeting (Member of the Organising Committee)
Universidade do Minho Escola de Medicina, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/03 - 2022/04 EMBO YIP Annual PhD Course - Two week course on scientific communication, manuscript writing, manuscript review, time management, research integrity.
Workshop
European Molecular Biology Laboratory, Germany
2014/01/06 - 2014/01/17 4th edition Biostatistics in Health Sciences
Workshop
Universidade do Minho Escola de Medicina, Portugal
2013/11/11 - 2013/11/29 9th edition Laboratory Animal Science course (FELASA C)
Workshop
Universidade do Minho Escola de Medicina, Portugal
2013/10/28 - 2013/11/08 5th edition of Research Methodologies
Workshop
Universidade do Minho Escola de Medicina, Portugal

Mentoring / Tutoring

Topic Student name
2021/11/01 - 2021/11/30 Initiation to Research Internship Mariana Malveiro Marianito
Distinctions

Award

2023 João Lobo Antunes Merit PhD Thesis Award
2022 Outstanding Speaker Award in the 9th Kinetoplastid Molecular Cell Biology Meeting
2021 Merit Award - 2nd best talk in XIV CAML · IV NeurULisboa PhD Students Virtual Meeting