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Margarida Domingues attained her Master’s Degree in Biomedical Engineering from Instituto Superior Técnico (IST) in 2023, during which she conducted her MSc thesis at the Institute for Bioengineering and Biosciences (iBB), focusing on the development of advanced 3D in vitro bone cancer models. Additionally, she holds a Bachelor’s Degree in Biomedical Engineering, also from IST, completed in 2021. Margarida's primary interests revolve around bioengineering strategies to advance in vitro cancer modelling and facilitate the discovery of novel anticancer therapies. During her time as a research assistant at iBB, Margarida (co-)authored three peer-reviewed publications and presented her work at several scientific conferences.
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Identification

Personal identification

Full name
MARGARIDA FAIA MILITÃO ESCALDA DOMINGUES

Citation names

  • Domingues, Margarida
  • Margarida Domingues

Author identifiers

Ciência ID
0916-44D1-1CF6
ORCID iD
0009-0002-1684-0349

Email addresses

  • margarida.domingues@tecnico.ulisboa.pt (Professional)
  • margarida.domingues@ua.pt (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Materials Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2024/04 - 2025/06
Concluded
 Advanced Formation Diploma in Methodologies and Techniques of Scientific Research (Outros)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2023
Concluded
 Mestrado integrado em Engenharia Biomédica (Mestrado integrado)
Major in Bioengenharia Molecular e Celular, Engenharia de Tecidos e Medicina Regenerativa
Universidade de Lisboa Instituto Superior Técnico, Portugal
"3D bioprinted model of Osteosarcoma using a decellularized extracellular matrix-based bioink" (THESIS/DISSERTATION)
 18
2022/02 - 2022/07
Concluded
 ERASMUS Exchange Program - Biomedical Engineering (Master)
Major in Bioengenharia Molecular e Celular, Engenharia de Tecidos e Medicina Regenerativa
Katholieke Universiteit Leuven Faculteit Bio-Ingenieurswetenschappen, Belgium
Affiliation

Others

Category
Host institution 		Employer
2024/04/01 - 2025/06/27 Research Assistant Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/08 - 2021/08 Internship at Unidade de Técnicas de Gastrenterologia Hospital de Santa Maria, Portugal
Projects

Grant

Designation Funders
2025/02 - 2025/06/27 InSilico4OCReg - In silico models guiding in vitro biophysical stimulation of biomimetic hierarchical scaffolds: a computational modelling approach towards functional osteochondral regeneration
PTDC/EME-SIS/0838/2021
Research Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2024/04/01 - 2024/10 Wirelessly activated multifunctional nanobioelectronics to enable novel oncological therapies
2022.07252.PTDC
Research Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Ezgi Oner; Kyle Storey; Margarida Domingues; Paola Sanjuan-Alberte; Gabriela S. Kronemberger; Stephen Finn; Gerard Fitzmaurice; et al. "High-throughput and consistent 3D bioprinting of lung cancer organoids". Paper presented in IACR 61st Annual Scientific Conference, 2025.
  2. Margarida Domingues; Frederico Castelo Ferreira; Paola Sanjuan-Alberte; João Carlos Silva. Corresponding author: João Carlos Silva. "Advancing Osteosarcoma in vitro modelling through the combination of 3D bioprinted spheroids with a decellularized cell-derived ECM-based bioink". Paper presented in Biomanufacturing Without Borders (BMWB) 2024, 2024.
  3. Margarida Domingues; Frederico Castelo Ferreira; Paola Sanjuan-Alberte; João Carlos Silva. "3D Advanced Osteosarcoma model using a decellularized cell-derived ECM-based bioink for in vitro anticancer therapy studies". Paper presented in 3rd International Multidisciplinary Conference on POLYMERS & CHEMISTRY, 2024.
  4. Margarida Domingues; Frederico Castelo Ferreira; Paola Sanjuan-Alberte; João Carlos Silva. "3D bioprinted spheroids in decellularized cell-derived ECM-based bioinks for the in vitro modelling of Osteosarcoma". Paper presented in 3rd iBB Workshop, 2023.
Journal article
  1. Margarida Domingues; Marta Carvalho; Sanjuan Alberte, Paola; João Carlos Silva. Corresponding author: João Carlos Silva. "Synthetic scaffolds functionalized with mesenchymal stem/stromal cells-derived extracellular matrix for bone tissue engineering: a review". RSC Advances (2025): 10.1039/d5ra02106e.
    Published
  2. Margarida Domingues; Maria Catarina Carreira; Mafalda Santos; Daniela Pacheco; Frederico Castelo Ferreira; Paola Sanjuan-Alberte; João Carlos Silva. Corresponding author: João Carlos Silva. "A 3D Bioprinted Spheroid-laden dECM-enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery". Advanced Healthcare Materials (2025):
    Under revision
  3. Domingues, Margarida F.; Silva, João C.; Sanjuan-Alberte, Paola. "From Spheroids to Bioprinting: A Literature Review on Biomanufacturing Strategies of 3D In Vitro Osteosarcoma Models". Advanced Therapeutics (2024): http://dx.doi.org/10.1002/adtp.202400047.
    10.1002/adtp.202400047
  4. Silvia Gonella; Margarida Domingues; Filipe Miguel; Carla Moura; Carlos A.V. Rodrigues; Frederico C. Ferreira; João C. Silva. Corresponding author: João C. Silva. "Fabrication and Characterization of Porous PEGDA Hydrogels for Articular Cartilage Regeneration". (2024): doi.org/10.3390/gels10070422.
Thesis / Dissertation
  1. "3D bioprinted model of Osteosarcoma using a decellularized extracellular matrix-based bioink". Master, Universidade de Lisboa Instituto Superior Técnico, 2023. https://fenix.tecnico.ulisboa.pt/cursos/mebiom21/dissertacao/565303595503767.
Activities

Association member

Society Organization name Role
2021 - 2023 IEEE-IST Student Branch Collaborator, Coordinator of the Design Team

Mentoring / Tutoring

Topic Student name
2024/04 - 2024/04 3D bioprinting of cartilage tissue-engineered constructs Patrícia Barros E Silva Amaro Baptista (Mestrado em Medicina da Universidade do Algarve)
Distinctions

Award

2022 ERASMUS Programme Mobility Grant

Other distinction

2023 Academic Excellence Diploma
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020 Academic Merit Diploma
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 Academic Excellence Diploma
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Academic Excellence Diploma
Universidade de Lisboa Instituto Superior Técnico, Portugal