Mariana Bernardo Fiadeiro (0813-C13F-2205)

Curriculum Vitae

Mariana Bernardo Fiadeiro

I obtained my Bachelor degree in Biotechnology (2016) and my Master degree in Biomedical Sciencies (2018), both from University of Beira Interior. My Master thesis was based in the modulatory effect of an innovative antioxidant formulation on Parkinson's disease (PD) neurodegeneration and neurogenesis. During my academic track I developed a dynamic and multidisciplinary profile, which gave me the opportunity to become a better researcher. After finishing my Master, on march 2019 I joined Dr. Yoon Seong-Kim's research group at University of Central Florida (UCF), in Burnett School of Biomedical Sciences, and my work was mainly focused on the epigenetic regulation of alpha-synuclein in the pathogenesis of PD. I held a research fellowship at the Health Sciences Research Centre at University of Beira Interior in 2020, and my scientific work aimed to characterize the toxicity and neuroprotective effect of new formulations of NADPH oxidase 1 inhibitor analogs in the context of PD. I held a research fellowship at the Health Sciences Research Centre at University of Beira Interior in 2021, and my scientific work aimed to investigate novel NOX1 inhibitor-based formulations to prevent neurodegeneration in PD context. In 2022, I started my PhD program/project in Biomedicine at University of Beira Interior and my main focus is to investigate new potential specific Nox1 inhibitors to reduce dopaminergic neuronal loss and new ionic liquid-based formulations to improve their bioavailability and effectiveness in the brain, in the context of PD. I am co-author of four scientific publications, with national and international collaborations. Besides that, I am co supervising several thesis projects from bachelor and master students, and I am also tutoring seminar classes for bachelor students.

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Identification

Personal identification

Full name: Mariana Bernardo Fiadeiro

Citation names

Fiadeiro, Mariana B.
Mariana B. Fiadeiro
Mariana Bernardo Fiadeiro

Author identifiers

Ciência ID: 0813-C13F-2205
ORCID iD: 0000-0001-8689-5666

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
Medical and Health Sciences - Basic Medicine - Neurosciences
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Advanced (C1)	Proficiency (C2)	Advanced (C1)
Spanish; Castilian	Upper intermediate (B2)	Advanced (C1)	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)

Education

	Degree	Classification
2022/01 - 2025/12 Ongoing	Biomedicina (Doutoramento) Major in Neurociências Universidade da Beira Interior, Portugal Universidade de Aveiro, Portugal
2022 - 2022 Concluded	Curso Pós - Graduado de Ciências em Animais de Laboratório - Categoria B FELASA (Outros) Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2022 - 2022 Concluded	2nd Advanced Course on Fluorescence Microscopy and Image Analysis (Outros) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/09/15 - 2018/11/07 Concluded	Ciências Biomédicas (Mestrado) Major in Neurociências Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal "Modulatory effect of innovative antioxidant formulation on Parkinson's disease neurodegeneration and neurogenesis" (THESIS/DISSERTATION)
2013/09/15 - 2016/07/11 Concluded	Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal

Affiliation

Science

	Category Host institution	Employer
2019/03/22 - 2020/02/28	Research Assistant (Research)	University of Central Florida, United States
	University of Central Florida Burnett School of Biomedical Sciences, United States

Others

	Category Host institution	Employer
2021/10 - 2021/12	Investigadora bolseira no projeto "New therapeutic approach to slow down the progression of Parkinson's disease-PDSolve" (CENTRO-01-0247-FEDER-113213 PDSolve-BIM2)	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

2020/05 - 2020/12	Investigadora bolseira no projeto "Interdisciplinary Challenges On Neurodegeneration-ICON" (CENTRO-01-0145-FEDER-000013 ICON-BIM-25)	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Projects

Contract

	Designation	Funders
2021 - 2023	PDSolve - New therapeutic approach to slowdown the progression of Parkinson's disease CENTRO-01-0247-FEDER-113213 Team member Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	European Regional Development Fund Concluded
2020/05 - 2020/12	Interdisciplinary Challenges On Neurodegeneration-ICON CENTRO010145FEDER000013 Research Fellow Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	European Regional Development Fund Concluded

Outputs

Publications

Conference abstract	Mariana B. Fiadeiro; Ana A. Silva; Ana C. Sousa; Samuel Silvestre; Marco Almeida; Márcia Neves; Mukesh Sharma; et al. "Novel Nox inhibitor ionic-liquid-based formulation to halt Parkinson's disease progression". Paper presented in IV Congresso Internacional em Investigação de Ciências da Saúde, Covilhã, 2023. Fiadeiro, Mariana; Silva, Ana Alexandra; Cristóvão, Ana Clara; Sousa, Ana Catarina; Silvestre, Samuel; Almeida, Marco; Neves, Márcia; et al. "Novel ionic-liquid-based formulation to prevent neurodegeneration in Parkinson's disease". Paper presented in Biopartitioning & Purification Conference (BPP), Aveiro, 2022. Mariana B. Fiadeiro; Ana A. Silva; Ana C. Sousa; Samuel Silvestre; Marco Almeida; Márcia Neves; Mukesh Sharma; et al. "Ionic-liquid-Nox inhibitor: a new approach to slow down neurodegeneration in Parkinson's disease". Paper presented in XVII Simpósio Internacional Anual do CICS - UBI, Covilhã, 2022. Mariana Fiadeiro; Ana Catarina Sousa; Marta Afonso; Mukesh Sharma; Liliana Bernardino; Mara Freire; Ana Clara Cristóvão. "New antioxidant formulation to prevent neuronal degeneration in Parkinson's disease". Paper presented in XIII Simpósio Anual d o CICS - UBI, Covilhã, 2018.
Conference poster	Mariana B. Fiadeiro; Ana A. Silva; Ana C. Sousa; Samuel Silvestre; Marco Almeida; Gilberto Alves; Sara Meirinho; et al. "Novel Ionic-Liquid-based Nox1 inhibitor as a new approach to slow down Parkinson's disease progression". Paper presented in FENS Regional Meeting (FRM), Albufeira, Portugal, 2023. Ana A. Silva; Mariana B. Fiadeiro; Liliana Bernardino; Graça Baltaza; Ana C. Cristóvão. "Neuroinflammation modulation in Parkinson's disease context". Paper presented in V Congresso Internacional em Investigação de Ciências da Saúde, CICS-UBI, Covilhã, Portugal, 2023. Beatriz Serra-Almeida; Mariana B. Fiadeiro; Ana A. Silva; Ana C. Sousa; Samuel Silvestre; Marco Almeida; Márcia Neves; et al. "Evaluation of the neuroprotective capacity of a novel Nox1 inhibitor formulation for Parkinson's Disease". Paper presented in XVII Simpósio Internacional Anual do CICS - UBI, Covilhã, Portugal, 2022. Ana A. Silva; Mariana B. Fiadeiro; Graça Baltazar; Ana C. Cristóvão. "Neuroinflammation modulation by 5-aminosalicylic acid". Paper presented in XVII Simpósio Internacional Anual do CICS - UBI, Covilhã, Portugal, 2022.
Journal article	da Silva, Ana Alexandra Flores; Fiadeiro, Mariana Bernardo; Bernardino, Liliana Inácio; Fonseca, Carla Sofia Pais; Baltazar, Graça Maria Fernandes; Cristóvão, Ana Clara Braz. ""Lipopolysaccharide-induced animal models for neuroinflammation – An overview."". Journal of Neuroimmunology 387 (2024): 578273. http://dx.doi.org/10.1016/j.jneuroim.2023.578273. 10.1016/j.jneuroim.2023.578273 Guhathakurta, Subhrangshu; Adams, Levi; Jeong, Inhye; Sivakumar, Anishaa; Cha, Mingyu; Bernardo Fiadeiro, Mariana; Hu, Haiyan Nancy; Kim, Yoon-Seong. "Precise epigenomic editing with a SunTag-based modular epigenetic toolkit". Epigenetics 17 13 (2022): 2075-2081. http://dx.doi.org/10.1080/15592294.2022.2106646. 10.1080/15592294.2022.2106646 Guhathakurta, Subhrangshu; Kim, Jinil; Adams, Levi; Basu, Sambuddha; Song, Min Kyung; Adler, Evan; Je, Goun; Fiadeiro, Mariana Bernardo; Kim, Yoon-Seong. "Targeted attenuation of elevated histone marks at SNCA alleviates a-synuclein in Parkinson's disease". EMBO Molecular Medicine 13 2 (2021): http://dx.doi.org/10.15252/emmm.202012188. 10.15252/emmm.202012188 Neves, Catarina M. S. S.; Figueiredo, Marcos; Reis, Patrícia M.; Sousa, Ana C. A.; Cristóvão, Ana C.; Fiadeiro, Mariana B.; Rebelo, Luís Paulo N.; et al. "Simultaneous Separation of Antioxidants and Carbohydrates From Food Wastes Using Aqueous Biphasic Systems Formed by Cholinium-Derived Ionic Liquids". Frontiers in Chemistry 7 (2019): http://dx.doi.org/10.3389/fchem.2019.00459. 10.3389/fchem.2019.00459
Thesis / Dissertation	Fiadeiro, Mariana. "Modulatory effect of innovative antioxidant formulation on Parkinson's disease neurodegeneration and neurogenesis". Master, Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, 2018.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022	Ionic-liquid-Nox inhibitor: a new approach to slowdown neurodegeneration in Parkinson ´s disease	XVII Simpósio Internacional Anual do CICS - UBI Universidade da Beira Interior (Portugal)
2018/07/05	"New antioxidant formulation to prevent neuronal degeneration in Parkinson's Disease"	XIII Annual CICS-UBI Symposium Universidade da Beira Interior Faculdade de Ciências da Saúde (Covilhã, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023 - 2023	"Identificação de novos biomarcadores para o diagnóstico precoce da doença de Parkinson no epitélio olfativo" Supervisor	Bioquímica (Degree) Universidade da Beira Interior, Portugal
2023 - 2023	"Identificação de novos biomarcadores no tecido do epitélio olfativo para o diagnóstico precoce da doença de Parkinson" Supervisor	Biotecnologia (Degree) Universidade da Beira Interior, Portugal
2022 - 2023	"Efeito modulatório de um inibidor das NADPH oxidases na expressão da a-sinucleína e da ß-amilóide num modelo in vivo da doença de Parkinson" Co-supervisor	Bioquímica (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022 - 2023	Otimização e implementação de um método de preparação de fibrilas de alfa-sinucleína para posterior desenvolvimento de um modelo animal da doença de Parkinson Co-supervisor	Bioquímica (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022 - 2022	"Vitamina E para o controlo do stress oxidativo em contexto de epilepsia" Supervisor	Bioquímica (Degree) Universidade da Beira Interior, Portugal
2021 - 2022	"Avaliação da capacidade neuroprotetora de uma nova formulação inibidora da NOX1 para a doença de Parkinson" Co-supervisor	Ciências Biomédicas (Master)
2020 - 2022	"Protective role of commercialized anti-inflammatory drugs in Parkinson's Disease pathogenesis, namely neuroinflammation" Co-supervisor	Bioquímica (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021 - 2021	"Pharmacological inhibition of NADPH oxidase 1 and 4 - impact on amyotrophic lateral sclerosis animal model" Co-supervisor	Biotecnologia (Degree) Universidade da Beira Interior, Portugal
2021 - 2021	"Identification of active pharmaceutical ingredients on the market with neuroprotective capacity in the context of Parkinson's Disease" Co-supervisor	Bioquímica (Degree) Universidade da Beira Interior, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2022 - 2022	Workshop "New Parkinson's Therapies" Integrado no evento "XIII Beira Interior Medical Meeting" (2022 - 2022) Workshop (Member of the Organising Committee)	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019 - 2019	Collaboration with the organizing committee of the Neuroscience Lab Open House (2019 - 2019) Meeting (Member of the Organising Committee)	University of Central Florida Burnett School of Biomedical Sciences, United States
2017 - 2017	Member of the organizing committee of the VI Employment and Opportunities Symposium (2017 - 2017) Symposium (Member of the Organising Committee)	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017 - 2017	Collaboration with the organizing committee of the 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2017 - 2017) Meeting (Co-organisor)	Universidade da Beira Interior, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2022 - 2022	Pilot Course carried out under the Erasmus+ Project entitled Enhancing the ENTRepreneurial mindset of non-business Academics in Europe (ENTRANCE) 2020-1-CY01-KA203-065982 Other	ENTRANCE Pilot Course Universidade da Beira Interior, Portugal

Committee member

	Activity description Role	Institution / Organization
2023 - Current	Comissão de Alunos de Doutoramento e Bolseiros de Investigação Member	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Mentoring / Tutoring

	Topic	Student name
2023 - 2023	"Investigação e empreendedorismo do desenvolvimento terapêutico para a Doença de Parkinson"	Ana Sofia Taborda Silvestre
2023 - 2023	"Investigação e empreendedorismo do desenvolvimento terapêutico para a Doença de Parkinson"	Bárbara Esteves Dias
2021/03 - 2021/06	"O empreendedorismo e as doenças neurológicas: Velhos medicamentos para novas abordagens terapêuticas"	Rita Isabel Caturrinho do Carmo
2021/03 - 2021/06	"O empreendedorismo e as doenças neurológicas: Velhos medicamentos para novas abordagens terapêuticas"	Ana Maria Caetano de Almeida

Distinctions

Award

2022	Best Oral Communication award at XVII International CICS-UBI Symposium Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018	Best short communication award at the XIII Annual CICS-UBI Symposium Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal