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Sónia Rocha is a PhD student in Pharmaceutical Sciences - Medicinal and Pharmaceutical Chemistry specialization, at the Faculty of Pharmacy of the University of Porto, under the PhD Programme in Medicines and Pharmaceutical Innovation. She obtained her Bachelor Degree (2016) in Biology, from the University of Aveiro and Master's Degree (2018) in Quality Control, with specialization in Medicines and Medicinal Plants, from the Faculty of Pharmacy of the University of Porto. Her scientific work research resulted in 10 publications in international journals, 1 book chapter, 5 oral communications in international conferences and 15 panel communications in national and international conferences.
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Identification

Personal identification

Full name
Sónia Aguiar da Rocha

Citation names

  • Rocha, Sónia

Author identifiers

Ciência ID
0810-42B5-1CAB
ORCID iD
0000-0001-7786-2731

Addresses

  • Laboratório de Química Aplicada, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira nº 228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2022
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Major in Química Farmacêutica e Medicinal
Universidade do Porto Faculdade de Farmácia, Portugal
2018/11/16
Concluded
 Controlo de Qualidade (Mestrado)
Major in Fármacos e Plantas Medicinais
Universidade do Porto Faculdade de Farmácia, Portugal
"Inhibitory Activity of Chalcones on Key Digestive Enzymes for the Management of Diabetes Mellitus" (THESIS/DISSERTATION)
 18 valores
2016/06/15
Concluded
 Biologia (Licenciatura)
Major in Biologia
Universidade de Aveiro, Portugal
 16 valores
Outputs

Publications

Book chapter
  1. Sónia Rocha; Maria Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Novel Strategies for Managing Diabetes Mellitus Using Lipid-Based Delivery Systems as Vehicles of Polyphenols". In Advances in Health and Disease. Volume 67. 2023.
    Published
Conference poster
  1. Sónia Rocha; Catarina Correia; Vera Silva; Artur Silva; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Polyphenols as potential modulators of type 2 diabetes mellitus through the inhibition of glycogen phosphorylase". Paper presented in 14th World Congress on Polyphenols Applications, 2021.
  2. Sónia Rocha; Mariana Lucas; Vera Silva; Artur Silva; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "The effect of pyrazoles on the emerging diabetic therapeutic targets: protein tyrosine phosphatase 1b and glycogen phosphorylase". Paper presented in 56th International Conference on Medicinal Chemistry (RICT 2021), 2021.
  3. Sónia Rocha; Mariana Lucas; Vera Silva; Artur Silva; Alberto Araújo; Natália Aniceto; Rita Guedes; et al. "Antidiabetic Potential of Pyrazoles: Exploring the Structure-Activity Relationship against Protein Tyrosine Phosphatase 1b and Glycogen Phosphorylase". Paper presented in iMed.Ulisboa Meeting 2021, 2021.
  4. Sónia Rocha; Mariana Lucas; Vera Silva; Artur Silva; Alberto Araújo; Natália Aniceto; Rita Guedes; et al. "Insight into the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of pyrazoles". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  5. Sónia Rocha; Maria Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Optimization of kinetic parameters to assess glycogen phosphorylase activity using a microanalysis method". Paper presented in 13th National Organic Chemictry Meeting – 6th National Medicinal Chemistry Meeting, 2020.
  6. Marisa Freitas; Sónia Rocha; Carina Proença; Daniela Ribeiro; Alberto N. Araújo; Artur M. S. Silva; Eduarda Fernandes. "Flavonoids versus chalcones: which are the most efficient inhibitors of key digestive enzymes in the management of diabetes mellitus?". Paper presented in 13th National Organic Chemictry Meeting – 6th National Medicinal Chemistry Meeting, 2020.
  7. Pedro Nicola; Marisa Freitas; Sónia Rocha; Félix Carvalho; Eduarda Fernandes; Daniela Ribeiro. "Optimization of a synaptosomal model to study the effect of carotenoids in peroxynitrite-induced lipid peroxidation". Paper presented in 13th YES Meeting, 2018.
  8. Sónia Rocha; Eduarda Fernandes; Marisa Freitas. "Screening of the anti-diabetic potential of chalcones through the inhibition of a-glucosidase and a-amylase". Paper presented in Italian, Spanish, Portuguese Joint Meeting in Medicinal Chemistry, 2018.
  9. Pedro Nicola; Marisa Freitas; Sónia Rocha; Félix Carvalho; Eduarda Fernandes; Daniela Ribeiro. "Synaptosomes as lipid models to study the inhibition of peroxynitrite-induced lipid peroxidation". Paper presented in Italian, Spanish, Portuguese Joint Meeting in Medicinal Chemistry, 2018.
  10. Sónia Rocha; Eduarda Fernandes; Marisa Freitas. "Inhibitory activity of chalcones on key digestive enzymes for the management of Diabetes mellitus". Paper presented in 11ª Edição do Encontro de Investigação Jovem da Universidade do Porto, 2018.
  11. Joana Magalhães; Alexandre C. C. Vieira; Sónia Rocha; Marcos S. Cardoso; Susana G. Santos; Margarida Borges; Marina Pinheiro; Salette Reis. "Rifampicin-loaded lipid nanoparticles to improve tuberculosis treatment: an active targeting approach". Paper presented in NanoBioMedConf, 2017.
Journal article
  1. Sónia Rocha; Andreia Amaro; Marcos D. Ferreira-Junior; Carina Proença; Artur M. S. Silva; Vera M. Costa; Sara Oliveira ; et al. "Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus". Pharmaceutics 16 2 (2024): 261. https://www.mdpi.com/1999-4923/16/2/261.
    Published
  2. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; Maria Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles". Nutrients (2022): https://doi.org/10.3390/nu14020306.
    10.3390/nu14020306
  3. Sónia Rocha; Mariana Lucas; Alberto N. Araújo; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Optimization and Validation of an In Vitro Standardized Glycogen Phosphorylase Activity Assay". Molecules 26 15 (2021): 4635-4635. https://doi.org/10.3390/molecules26154635.
    10.3390/molecules26154635
  4. Sónia Rocha; Mariana Lucas; Daniela Ribeiro; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment". Pharmacological Research 169 (2021): 105604-105604. https://doi.org/10.1016/j.phrs.2021.105604.
    10.1016/j.phrs.2021.105604
  5. Rocha, S.; Lucas, M.; Silva, V.L.M.; Gomes, P.M.O.; Silva, A.M.S.; Araújo, A.N.; Aniceto, N.; et al. "Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study". International Journal of Biological Macromolecules 181 (2021): 1171-1182. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105829306&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2021.04.061
  6. Sónia Rocha; Adelaide Sousa; Daniela Ribeiro; Catarina M. Correia; Vera L. M. Silva; Clementina M. M. Santos; Artur M. S. Silva; et al. "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives.". Food & function 10 (2019): 5510-5520. https://doi.org/10.1039/c9fo01298b.
    10.1039/c9fo01298b
  7. Sónia Rocha; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas. "Systematic review on anti-diabetic properties of chalcones.". Current Medicinal Chemistry (2018): https://doi.org/10.2174/0929867325666181001112226.
    10.2174/0929867325666181001112226
  8. Alexandre C.C. Vieira; Joana Magalhães; Sónia Rocha; Marcos S. Cardoso; Susana G. Santos; Margarida Borges; Marina Pinheiro; Salette Reis. "Targeted macrophages delivery of rifampicin-loaded lipid nanoparticles to improve tuberculosis treatment". Nanomedicine 12 24 (2017): 2721-2736. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034973715&partnerID=MN8TOARS.
    10.2217/nnm-2017-0248
  9. Maria Bartolomeu; Sónia Rocha; Ângela Cunha; M. G. P. M. S. Neves; Maria A. F. Faustino; Adelaide Almeida. "Effect of photodynamic therapy on the virulence factors of Staphylococcus aureus". Frontiers in Microbiology 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964370018&partnerID=MN8TOARS.
    10.3389/fmicb.2016.00267
Online resource
  1. Sónia Rocha; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. The Emerging Target Protein Tyrosine Phosphatase 1B (PTP1B) for Type 2 Diabetes Mellitus Management. 2021. https://www.scientificarchives.com/admin/assets/articles/pdf/the-emerging-target-protein-tyrosine-phosphatase-1b-ptp1b-for-type-2-diabetes-mellitus-management-20211119011116.pdf.
Thesis / Dissertation
  1. Sónia Aguiar da Rocha. "Inhibitory Activity of Chalcones on Key Digestive Enzymes for the Management of Diabetes Mellitus". Master, 2018. https://hdl.handle.net/10216/117719.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/23 Exploring the Modulatory Effects of Flavonoids and Pyrazoles in Hepatic Insulin Resistance and Glucose Metabolism in Non-Cellular and Cellular Models XXVII Encontro Luso Galego de Química
2023/11/09 Targeting hepatic glucose and glycogen metabolism by flavonoids On-line Workshop ''Usefulness of dietary bioactive compounds and probiotics in promoting health''
2021/11/18 Optimization of In Vitro Experimental Conditions for Glycogen Phosphorylase Inhibition Assay and Demonstration of High Inhibitory Effectiveness by Chromone Derivatives II Bio.Natural -Bioactive Natural Products Research Meeting (Bio.Natural-2021)
2018/11/22 Chalcones as a-amylase and a-glucosidase inhibitors for the management of diabetes mellitus XXIV Encontro Luso-Galego de Química
Sociedade Portuguesa de Química (Porto, Portugal)
2018/11/22 Development and application of a synaptosomal model for the study of peroxynitrite-induced lipid peroxidation XXIV Encontro Luso-Galego de Química
Sociedade Portuguesa de Química (Porto, Portugal)