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Dinora Lopes. trabalha na área de Ciências biomédicas com ênfase em parasitologia e biologia Molecular. O seu trabalho tem sido desenvolvido no estudo de resistência a antimaláricos e a sua associação a polimorfismos em genes potencialmente relacionados com este fenotipo.
Identification

Personal identification

Full name
Dinora Lopes

Citation names

  • Lopes, Dinora
  • D lopes

Author identifiers

Ciência ID
071F-3972-2E73
ORCID iD
0000-0003-0129-7603

Telephones

Mobile phone
  • 919456356 (Personal)
Telephone
  • 213652600 Ext.: 121 (Personal)

Addresses

  • Rua da Junqueira, 100, 1439-008, lisboa, Lisboa, Portugal (Professional)
  • Travessa Fernando de Alarcão, nº1, 2560 256, torres vedras, Torres Vedras, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences - Parasitology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
2023/11/08 - 2023/11/09
Concluded
 Sistemas de Gestão da Qualidade - Implementação da NP EN ISO 9001:2015 (Outros)
Instituto Português da Qualidade, Portugal
2023/01/09 - 2023/02/17
Concluded
 Microcredencial em Educação à Distância e Digital: projeto de UC em ambiente digital (Outros)
Universidade Aberta, Portugal
 19
2022/11/14 - 2022/12/11
Concluded
 Microcredencial em Educação à Distância e Digital: E-atividades no desenho de cursos (Outros)
Universidade Aberta, Portugal
 18
2022/10/10 - 2022/11/04
Concluded
 Microcredencial em Educação à Distância e Digital: Docência Digital em Rede (Outros)
Universidade Aberta, Portugal
 19
2019/10/22 - 2019/10/24
Concluded
 Biosafety workshop (Outros)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
2019/09/25 - 2019/09/27
Concluded
 BSL3 facilities focus on biocontainment on insectary production and virus infections and manipulation (Outros)
Major in Biosafety
Universitat Autònoma de Barcelona, Spain
2018/06/08 - 2018/06/08
Concluded
 Evaluation of severity according to directive 2010/63/EU (Outros)
Instituto de Ciências da Terra Polo do Universidade do Minho, Portugal
2018/04/17 - 2018/04/18
Concluded
 Arthropods: Invertebrates – facilities and handling (Outros)
Danmarks Tekniske Universitet Dansk Polymer Centre, Denmark
2000/01/02 - 2005/05/25
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Biologia Celular e Molecular
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"Antimalarial resistance in Plasmodium falciparum: involvement of pfcrt and pfmdr1 genes" (THESIS/DISSERTATION)
 aprovada por unanimidade
2004/03/01 - 2004/06/30
Concluded
 Tecnico Superior de Higiene e segurança do trabalho (Curso Técnico Superior Profissional)
Instituto Superior Politécnico do Oeste, Portugal
1991/09/15 - 1998/10/30
Concluded
 Engenharia biotecnológica (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Study of the sensitivity of DNA extraction and PCR techniques for identification of Plasmodium species" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2021/11/01 - Current Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2016 - 2018 Assistant (University Teacher) Universidade Nova de Lisboa, Portugal

Positions / Appointments

Category
Host institution 		Employer
2025/03/18 - Current Chairman of the Ethics Committee Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2021/06/21 - Current Operational Manager of VIASEF – In vivo Arthropod Security Facility Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/02/06 - Current Coordinator of IHMT Occupational Health and Biosafety Committee Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/11/06 - Current Head of Science and Community Support Service Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2008/09/02 - Current Member of IHMT Ethical Commission Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2006/08/01 - Current Head of animal house facility Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Others

Category
Host institution 		Employer
2023/03/04 - Current Member of scientific committee of In vivo Arthropod Security Facility Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/07/28 - Current President of IHMT Animal Welfare Body Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Projects

Contract

Designation Funders
2018 - 2023 Vaccine for prevention and treatment of Trypanosoma cruzi infection
815418
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Ongoing
2018 - 2021 Identification of new antimalarial treatments through a target-centred "drug repositioning" approach
PTDC/SAU-PAR/28459/2017
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Ongoing
2017 - 2021 Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target
PTDC/BIA-MIC/31645/2017
Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Ongoing
2015 - 2020 In Vivo Arthropod Security Facility
22077
Other
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Ongoing
2010 - 2015 The hemozine crystal structure as a target: a rational approach to the design of new antimalarials
PTDC / SAU-FAR / 114864/2009
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
2011/03/01 - 2014/08/31 A ESTRUTURA DO CRISTAL DE HEMOZOÍNA COMO ALVO: UMA ABORDAGEM RACIONAL PARA O DESENHO DE NOVOS ANTIMALÁRICOS
PTDC/SAU-FAR/114864/2009
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2014 Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal activity
PTDC / QUI / 65142/2006
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
Outputs

Publications

Conference poster
  1. Ramalhete, Cátia; Lopes, Dinora; Molnár, Joseph; Mulhovo, Silva; Prof. Virgilio Estólio do Rosário; Prof. Maria José Umbelino Ferreira. "Antimalarial activity of triterpenoids with the cucurbitane skeleton". Paper presented in 7th Tannin Conference (Presymposium) and 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2010.
  2. Ramalhete, Cátia; Lopes, Dinora; Mulhovo, Silva; Prof. Virgilio Estólio do Rosário; Prof. Maria José Umbelino Ferreira. "Screening for antimalarial activity of crude extracts from African medicinal plants". Paper presented in 7th Joint Meeting of GA, AFERP, ASP, PSE & SIF, 2008.
  3. Portela, César; Lopes, Dinora; Nogueira, Fátima; Rosário, Virgílio; Afonso, Carlos; Pinto, Madalena. "Antimalarial activity of new xanthonic compounds". Paper presented in Medicinal Chemistry in the 21st Century, 2006.
Journal article
  1. de Sousa, Taís Nóbrega; Machado, Patricia Carneiro; Lopes, Inês; Das Neves, Edvaldo; Narciso, Alda; Pires, Anastácio; Santos, Adalberto; et al. "Extensive low-density Plasmodium falciparum reservoir in the island of Príncipe, an isolated malaria pre-elimination setting". International Journal of Infectious Diseases 147 (2024): 107220. http://dx.doi.org/10.1016/j.ijid.2024.107220.
    10.1016/j.ijid.2024.107220
  2. Kiaco, Kinanga; Rodrigues, António Sebastião; do Rosário, Virgílio; Gil, José Pedro; Lopes, Dinora. "The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome". Malaria Journal 16 1 (2017): http://dx.doi.org/10.1186/s12936-017-2006-6.
    10.1186/s12936-017-2006-6
  3. Kiaco, Kinanga; Teixeira, Joana; Machado, Marta; do Rosário, Virgílio; Lopes, Dinora. "Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola". Malaria Journal 14 1 (2015): http://dx.doi.org/10.1186/s12936-015-1018-3.
    10.1186/s12936-015-1018-3
  4. de A. Silva, JeffersonRocha; do Carmo, DominiqueF. M.; Amaral, Ana ClaudiaF; Machado, Marta; Lopes, Dinora; Echevarria, Aurea; Rosário, VirgílioE. "Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus". Pharmacognosy Magazine 11 44 (2015): 244. http://dx.doi.org/10.4103/0973-1296.166071.
    10.4103/0973-1296.166071
  5. Inoue, Juliana; Lopes, Dinora; do Rosário, Virgílio; Machado, Marta; Hristov, Angélica D; Lima, Giselle FMC; Costa-Nascimento, Maria J; Segurado, Aluísio C; Di Santi, Silvia M. "Analysis of polymorphisms in Plasmodium falciparum genes related to drug resistance: a survey over four decades under different treatment policies in Brazil". Malaria Journal 13 1 (2014): http://dx.doi.org/10.1186/1475-2875-13-372.
    10.1186/1475-2875-13-372
  6. Paulo, Alexandra; Figueiras, Marta; Machado, Marta; Charneira, Catarina; Lavrado, João; Santos, Sofia A.; Lopes, Dinora; et al. "Bis-alkylamine Indolo[3,2-b]quinolines as Hemozoin Ligands: Implications for Antimalarial Cytostatic and Cytocidal Activities". Journal of Medicinal Chemistry 57 8 (2014): 3295-3313. http://dx.doi.org/10.1021/jm500075d.
    10.1021/jm500075d
  7. Neto, Zoraima; Machado, Marta; Lindeza, Ana; do Rosário, Virgílio; Gazarini, Marcos L.; Lopes, Dinora. "Treatment ofPlasmodium chabaudiParasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System". Journal of Parasitology Research 2013 (2013): 1-11. http://dx.doi.org/10.1155/2013/429736.
    10.1155/2013/429736
  8. Ramalhete, Cátia; da Cruz, Filipa P.; Lopes, Dinora; Mulhovo, Silva; Rosário, Virgílio E.; Prudêncio, Miguel; Ferreira, Maria-José U.. "Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections". Bioorganic & Medicinal Chemistry 19 24 (2011): 7474-7481. http://dx.doi.org/10.1016/j.bmc.2011.10.044.
    10.1016/j.bmc.2011.10.044
  9. Silva, Jefferson Rocha de A; Ramos, Aline de S; Machado, Marta; Moura, Dominique F de; Zoraima Neto; Canto-Cavalheiro, Marilene M; Figueiredo, Paula; et al. "A review of antimalarial plants used in traditional medicine in communities in Portuguese-Speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola". Memórias do Instituto Oswaldo Cruz 106 suppl 1 (2011): 142-158. http://dx.doi.org/10.1590/s0074-02762011000900019.
    10.1590/s0074-02762011000900019
  10. Albuquerque, David; Manco, Licínio; Loua, Kovana M.; Arez, Ana Paula; Trovoada, Maria de Jesus; Relvas, Luís; Millimono, Tamba S.; et al. "SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples". Annals of Human Biology 38 3 (2011): 378-381. http://dx.doi.org/10.3109/03014460.2010.541496.
    10.3109/03014460.2010.541496
  11. Ramalhete, Cátia; Lopes, Dinora; Molnár, Joseph; Mulhovo, Silva; Rosário, Virgílio E.; Ferreira, Maria-José U.. "Karavilagenin C derivatives as antimalarials". Bioorganic & Medicinal Chemistry 19 1 (2011): 330-338. http://dx.doi.org/10.1016/j.bmc.2010.11.015.
    10.1016/j.bmc.2010.11.015
  12. Fortes, Filomeno; Dimbu, Rafael; Figueiredo, Paula; Neto, Zoraima; do Rosário, Virgílio E; Lopes, Dinora. "Evaluation of prevalence's of pfdhfr and pfdhps mutations in Angola". Malaria Journal 10 1 (2011): 22. http://dx.doi.org/10.1186/1475-2875-10-22.
    10.1186/1475-2875-10-22
  13. Lavrado, João; Gani, Kaamil; Nobre, Pedro A.; Santos, Sofia A.; Figueiredo, Paula; Lopes, Dinora; Rosário, Virgílio do; et al. "Bis-alkylamine quindolone derivatives as new antimalarial leads". Bioorganic & Medicinal Chemistry Letters 20 19 (2010): 5634-5637. http://dx.doi.org/10.1016/j.bmcl.2010.08.043.
    10.1016/j.bmcl.2010.08.043
  14. Ramalhete, Cátia; Lopes, Dinora; Mulhovo, Silva; Molnár, Joseph; Rosário, Virgílio E.; Ferreira, Maria-José U.. "New antimalarials with a triterpenic scaffold from Momordica balsamina". Bioorganic & Medicinal Chemistry 18 14 (2010): 5254-5260. http://dx.doi.org/10.1016/j.bmc.2010.05.054.
    10.1016/j.bmc.2010.05.054
  15. Afonso, Ana; Neto, Zoraima; Castro, Helena; Lopes, Dinora; Alves, Ana C; Tomás, Ana M; Rosário, Virgílio D. "Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene". Malaria Journal 9 1 (2010): http://dx.doi.org/10.1186/1475-2875-9-135.
    10.1186/1475-2875-9-135
  16. Freire, Cristina; Podczeck, Fridrun; Ferreira, Dinora; Veiga, Francisco; Sousa, João; Pena, Angelina. "Assessment of the in-vivo drug release from pellets film-coated with a dispersion of high amylose starch and ethylcellulose for potential colon delivery". Journal of Pharmacy and Pharmacology 62 1 (2010): 55-61. http://dx.doi.org/10.1211/jpp.62.01.0005.
    10.1211/jpp.62.01.0005
  17. Manco, Licínio; Machado, Patrícia; Lopes, Dinora; Nogueira, Fátima; Do Rosário, Virgílio E.; Alonso, Pedro L.; Varandas, Luís; et al. "Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples". American Journal of Human Biology 21 1 (2009): 118-120. http://dx.doi.org/10.1002/ajhb.20819.
    10.1002/ajhb.20819
  18. Figueiredo, Paula; Benchimol, Carla; Lopes, Dinora; Bernardino, Luís; do Rosário, Virgílio E; Varandas, Luís; Nogueira, Fátima. "Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola". Malaria Journal 7 1 (2008): http://dx.doi.org/10.1186/1475-2875-7-236.
    10.1186/1475-2875-7-236
  19. Abrantes, Marta; Mil-Homens, Tânia; Duarte, Noélia; Lopes, Dinora; Cravo, Pedro; Madureira, Maria; Ferreira, Maria-José. "Antiplasmodial Activity of Lignans and Extracts fromPycnanthus angolensis". Planta Medica 74 11 (2008): 1408-1412. http://dx.doi.org/10.1055/s-2008-1081317.
    10.1055/s-2008-1081317
  20. Lopes, Dinora. "Updated studies on Ampelozizyphus amazonicus, a medicinal plant used in the Amazonian Region". Pharmacognosy Reviews 2 4 (2008): 308-316. http://www.phcogrev.com.
    Open access • Published
  21. Lopes, Dinora. "Plasmodium falciparum multidrug resistance protein (MRP) gene expression under chloroquine and mefloquine challenge". Journal of Cell and Animal Biology 2 1 (2008): 10-20.
    Open access • Published
  22. Portela, César; Afonso, Carlos M. M.; Pinto, Madalena M. M.; Lopes, Dinora; Nogueira, Fátima; do Rosário, Virgílio. "Synthesis and Antimalarial Properties of New Chloro-9H-xanthones with an Aminoalkyl Side Chain". Chemistry & Biodiversity 4 7 (2007): 1508-1519. http://dx.doi.org/10.1002/cbdv.200790130.
    10.1002/cbdv.200790130
  23. Ferreira, Isabel D.; Lopes, Dinora; Martinelli, Axel; Ferreira, Conceição; Do Rosário, Virgílio E.; Cravo, Pedro. "In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe". Tropical Medicine & International Health 12 3 (2007): 353-362. http://dx.doi.org/10.1111/j.1365-3156.2006.01789.x.
    10.1111/j.1365-3156.2006.01789.x
  24. Ferreira, Isabel D.; Lopes, Dinora; Martinelli, Axel; Ferreira, Conceição; Do Rosário, Virgílio E.; Cravo, Pedro. "In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe". Tropical Medicine & International Health 12 3 (2007): 353-362. http://dx.doi.org/10.1111/j.1365-3156.2006.01789.x.
    10.1111/j.1365-3156.2006.01789.x
  25. Cravo, P.; Figueiredo, S.; Nogueira, F.; Lopes, D.; Ferreira, I. D.; Ferreira, C.; Gil, J. P.; do Rosario, V. E.. "High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, amongPlasmodium falciparumisolates from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine & Parasitology 98 3 (2004): 293-296. http://dx.doi.org/10.1179/000349804225003262.
    10.1179/000349804225003262
  26. Drakeley, C.; Schellenberg, D.; Kihonda, J.; Sousa, C. A.; Arez, A. P.; Lopes, D.; Lines, J.; et al. "An estimation of the entomological inoculation rate for Ifakara: a semi-urban area in a region of intense malaria transmission in Tanzania". Tropical Medicine and International Health 8 9 (2003): 767-774. http://dx.doi.org/10.1046/j.1365-3156.2003.01100.x.
    10.1046/j.1365-3156.2003.01100.x
  27. Montoya, L.; Maestre, A.; Carmona, J.; Lopes, D.; Do Rosario, V.; Blair, S.. "Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity". Experimental Parasitology 104 1-2 (2003): 14-19. http://dx.doi.org/10.1016/s0014-4894(03)00112-7.
    10.1016/s0014-4894(03)00112-7
  28. Gil, J.P.; Nogueira, F.; Strömberg-Nörklit, J.; Lindberg, J.; Carrolo, M.; Casimiro, C.; Lopes, D.; et al. "Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)". Molecular and Cellular Probes 17 2-3 (2003): 85-89. http://dx.doi.org/10.1016/s0890-8508(03)00006-9.
    10.1016/s0890-8508(03)00006-9
  29. Lopes, Dinora; Rungsihirunrat, Kanchana; Nogueira, Fátima; Seugorn, Aree; Gil, José; do Rosário, Virgilio E; Cravo, Pedro. "Molecular Characterisation of Drug-resistant Plasmodium falciparum from Thailand". Malaria Journal 1 1 (2002): 12. http://dx.doi.org/10.1186/1475-2875-1-12.
    10.1186/1475-2875-1-12
  30. Pinto, João; Sousa, Carla A.; Gil, Vilfrido; Ferreira, Conceição; Gonçalves, Luzia; Lopes, Dinora; Petrarca, Vincenzo; Charlwood, J.Derek; do Rosário, Virgi´lio E.. "Malaria in São Tomé and Pri´ncipe: parasite prevalences and vector densities". Acta Tropica 76 2 (2000): 185-193. http://dx.doi.org/10.1016/s0001-706x(00)00100-5.
    10.1016/s0001-706x(00)00100-5
  31. Pinto, J.; Sousa, C.A.; Gil, V.; Gonçalves, L.; Lopes, D.; do Rosário, V.E.; Charlwood, J.D.. "Mixed-species malaria infections in the human population of São Tomé island, West Africa". Transactions of the Royal Society of Tropical Medicine and Hygiene 94 3 (2000): 256-257. http://dx.doi.org/10.1016/s0035-9203(00)90311-0.
    10.1016/s0035-9203(00)90311-0
  32. Arez, A.P.; Lopes, D.; Pinto, J.; Franco, A.S.; Snounou, G.; do Rosário, V.E.. "Plasmodium sp.: Optimal Protocols for PCR Detection of Low Parasite Numbers from Mosquito (Anopheles sp.) Samples". Experimental Parasitology 94 4 (2000): 269-272. http://dx.doi.org/10.1006/expr.2000.4496.
    10.1006/expr.2000.4496
Thesis / Dissertation
  1. KIACO, Kinanga. "Malária por Plasmodium falciparum em Angola: estudos genéticos associados a combinações terapêuticas à base de artemisinina". PhD, 2018. http://hdl.handle.net/10362/59492.
  2. NETO, Zoraima Naymbi da Silva. "Biological characterization of de-ubiquitylating enzymes (UBPs/UCHs) in Plasmodium spp as potential drug targets". PhD, 2014. http://hdl.handle.net/10362/19274.
  3. Nogueira, Marisa Frias. "Síntese e avaliação de derivados bis-alquilamina de quindolonas como protótipos de novos antimaláricos bifuncionais". Master, 2011. http://hdl.handle.net/10451/11204.
  4. BALDINO, Ana Carina Coutinho. "Estudos da variabilidade dos níveis de expressão de genes envolvidos na metabolização de antimaláricos em Mus musculus". Master, 2008. http://hdl.handle.net/10362/19219.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/12 - Current Study of the prevalence of polymorphisms in the pfhrp2 gene in the provinces of Bengo and Luanda in Angola and their impact on the diagnosis of Plasmodium falciparum
Co-supervisor
 Mestrado em Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022/09/01 - Current Molecular analysis of resistance factors to therapy and diagnosis of Plasmodium falciparum in São Tomé and Príncipe - genetic investigation of malaria cases in STP
Supervisor
 Mestrado Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/01/31 - 2023/10/29 Malaria studies in São Tomé and Príncipe
Co-supervisor
 Estágios APXXI (Other)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/03/07 - 2023/06/04 Analysis of the 1042 polymorphism of the pfmdr1 gene in Plasmodium falciparum and São Tome and Principe
Supervisor
 Erasmus+ (Other)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2018/10/19 - 2022 Study of TIP-SP on pregnancy in Angola
Co-supervisor
 Ciências biomédicas (PhD)
Universidade Agostinho Neto Faculdade de Medicina, Angola
2011/01/02 - 2018/12/14 Study of CYP, MDR1, CAR and PXR gene diversity and their role in metabolizing ACTs in Plasmodium falciparum malaria patients
Supervisor
 Doutoramento em Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/09/24 - 2015/04/19 Bioprospecting deep-sea marine fatty acids from the Azores for possible therapeutic application
Co-supervisor
 biotecnologia marinha (PhD)
Universidade dos Açores, Portugal
2010/02/15 - 2014/06/04 Molecular Markers for analysis of genetic polymorphism related to Plasmodium falciparum response to antimalarials
Co-supervisor
 Doenças infecciosas e parasitárias (PhD)
Universidade de São Paulo, Brazil
2007/05/17 - 2014/03/27 Chemical and Pharmacological Investigation of Amazonian Plant Species against Leishmania and Malaria
Co-supervisor
 Química (PhD)
Universidade Federal do Amazonas, Brazil
2013/02/23 - 2013/06/29 Evaluation of the activity of fractions of marine organisms in the erythrocyte phase of Plasmodium falciparum
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2013/02/22 - 2013/06/29 Study of the prevalence of polymorphisms in Plasmodium falciparum pfmdr1 and atp6 genes in Angolan patients
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2008/10/08 - 2013/06/05 Biological Characterization of the Deubiquitination Enzyme (UBP-1) in Plasmodium spp
Supervisor
 Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2012 Pharmacological studies of curcumin and gene expression studies of pfuchl1, pfuchl3 and pfubp8 in Plasmodium chabaudi as a response to antimalarial drugs and curcumin
Co-supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012 - 2012 Molecular Studies on Plasmodium falciparum Susceptibility to ACT's in Angolan Children
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012 - 2012 In vitro and in vivo studies of antimalarial activity of pure extracts, fractions and compounds obtained from the Ampelozyziphus amazonicus plant, in the invasion and development of the liver cycle
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012 - 2012 Study of the Phenotype Association of the Resistance to Diversity of Host CYPs, MDR1, CAR, and PXR Genes and Parasite Genes in P. falciparum Patients in Angola
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2009/09/10 - 2011/07/23 Synthesis and evaluation of bis-alkylamine derivatives of quindolones as prototypes of new bifunctional antimalarials
Supervisor
 Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2011 Analysis of in vitro antimalarial activity of extracts obtained from the Ampelozyziphus amazonicus plant in the liver phase
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011 - 2011 Evaluation of antimalarial activity in the erythrocyte phase of Plasmodium falciparum of compounds obtained from extracts of the Ampelozyziphus amazonicus plant
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/02/01 - 2010/10/03 Search for antimalarial compounds from Pycnanthus angolensis
Co-supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2010 Chemical and Pharmacological Evaluation of Ampelozyziphus amazonicus
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2009 - 2010 Chemical and pharmacological evaluation of Ampelozyziphus amazonicus, a plant species used for malaria prophylaxis
Co-supervisor
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009 - 2009 Evaluation of antimalarial activity of extracts of the Amapelozyziphus amazonicus Ducke plant
Supervisor
 Farmácia (Degree)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/10/04 - 2008/07/20 Study of expression levels of CYP, MDR and transcription factors induced by artemisinin and primaquine in different Mus muscullus strains
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - 2008 Studies of the association of CYP3A5 polymorphisms with in vivo resistance to quinine
Supervisor
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/12/05 - Current 7º National ORBEAs Symposium on the theme: The duty and challenges of monitoring projects (2022/12/05)
Symposium (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2023/04/20 - 2023/04/21 Member of scientific committee of 6th National Congress of Tropical Medicine (2023/04/20 - 2023/04/21)
Congress (Member of the Scientific Committee)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/07/05 - 2023/07/07 Participation in the 2nd International Medical Congress of the Private University of Angola, with the theme: Public Health, transversality in sustainable primary care
Congress
 2nd International Medical Congress
Universidade Privada de Angola, Angola

Committee member

Activity description
Role 		Institution / Organization
2023/04/21 - Current Member of Technical and Scientific Committee in the process of creating a National Authority for Biological Defense (ANDB)
Member
2023/01/17 - Current Within the framework of the university's quality policy, i was appointed as quality delegate for the science and community support service.
Member
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010 - Current Member of the IHMT Ethics Council (CEIHMT) - Evaluation of projects submitted to CEIHMT, particularly projects involving the use of animals.
Member
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Consulting

Activity description Institution / Organization
2021/10/04 - 2022/12/31 Evaluation of the quality of diagnosis for the identification of Plasmodium carried out in São Tomé and Príncipe, by comparison with molecular biology techniques Ministério da Saúde de São Tomé e Príncipe, São Tomé and Príncipe

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/06/26 - 2023/06/28 Biosafety Analises clínicas (Licence) Universidade de São Tomé e Príncipe, São Tomé and Príncipe
2022/06/06 - 2022/06/10 Seminar on "Ethics in health research" (Postgraduate Certificate) Universidade de Cabo Verde, Cape Verde
2011/02/21 - 2011/02/23 Parasitological and molecular techniques applied to antimalarial resistance monitoring
2010/05/03 - 2010/05/07 Studies on antimalarial activity of medicinal plants
2009/11/16 - 2009/11/16 Studies on antimalarial activity of medicinal plants
2008/12/02 - 2008/12/12 Workshop on “Basic Molecular Biology Techniques
2008/07/07 - 2008/07/11 Workshop on Parasitology
2006/03/21 - 2006/03/26 Antimalarial Resistance Workshop

Mentoring / Tutoring

Topic Student name
2022/12/19 - Current Molecular Biology applied to parasite diagnosis Constantina Machado
Distinctions

Award

2011 Prize of Biomedical Research of the Order of Doctors of Angola
Ordem dos médicos de Angola, Angola