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Sandra Silva graduated in Pharmaceutical Sciences, holds a PhD in Pharmacy/Food Science and is a Specialist in Pharmaceutical Industry/Qualified Person by the Portuguese Pharmaceutical Society. At iBET she is a Researcher at the Food and Health Division, Analytical Scientist at the Analytical Services Unit (GMP compliant) and Responsible for the management of controlled substances (including Cannabis plant). Her work deals with development, qualification and validation of spectrometric (UV/Vis, FTIR-ATR) and chromatographic methods (UPLC, HPLC and GC coupled with different detectors including mass spectrometry) applied to the chemical characterization of plants, food samples, by-products of Agroindustry and pharmaceutical products.
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Identification

Personal identification

Full name
Sandra Silva

Citation names

  • Silva, Sandra

Author identifiers

Ciência ID
071E-78FF-2B98
ORCID iD
0000-0003-2779-1781

Telephones

Telephone
  • 214469781 (Professional)

Addresses

  • Apartado 12, 2781-901, Oeiras, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Agrarian Sciences - Agrarian and Food Biotechnology
  • Exact Sciences - Chemical Sciences - Analytical Chemistry
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/11
Concluded
 Especialista em Indústria Farmacêutica (Título de especialista)
Major in Indústria Farmacêutica
Ordem dos Farmaceuticos, Portugal
 Aprovado
2017
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Bromatologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
"The importance of phenolic compounds to the biological activity of Virgin Olive Oil " (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2001 - 2004
Concluded
 Controlo da Qualidade e Toxicologia dos Alimentos (Especialização pós-licenciatura)
Major in Bromatologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Muito Bom
1991 - 1997
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
1998/04/13 - Current Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal

Others

Category
Host institution 		Employer
1997 - 1998 Bolseira Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2018 - 2020 Looking for Efficient Salt Substitutes: an encapsulated blend with olive oil, herbs, salicornia and microalgae (LESSSalt)
iBETXplore (referência IBET: PI 715)
Researcher
2018 - 2019 The effect of olive oil compounds in the prevention of UV-induced melanomagenesis
Inova 4Health 39 (referência IBET: P835)
Researcher
2018 - 2019 Omics approaches to investigate the anticancer properties of colonic metabolites derived from Virgin Olive Oil (Voomics)
iBETXplore (referência iBET: PI 711)
Researcher
2017 - 2019 PRevenção da Artrite Reumatóide: Suplemento de HIdroxitirosol em AZeite refinado (PRARHITAZ)
Projeto Fundação Amélia de Mello (Referência iBET: P574)
Projeto Fundação Amélia de Mello (Referência iBET: P574)
Researcher
N/A
2017 - 2019 Efficacy of olive oil and phenolic compounds in reversing hypertension induced by chronic intermitente hypoxia
Inova 4Health 35 (referência iBET: P829)
Researcher
2010 - 2012 Azeite+Global
QREN nº 12228
Researcher
2005 - 2006 Estudos de fermentação de azeitona de mesa da cultivar ¿Azeiteira¿
* Project AGRO 463 Acção 8.1, Medida 8 do Programa AGRO
* Project AGRO 463 ¿ Acção 8.1, Medida 8 do Programa AGRO
Researcher
N/A
2004 - 2006 Azeitona de mesa do Nordeste Alentejano. Melhoramentos tecnológicos para a implementação da Denominação de Origem Protegida
AGRO 43003
Researcher
2004 - 2005 Natural Antioxidants
POE-Medida 3.1, Cont.: 03/2003/00068/192
POE-Medida 3.1, Cont.: 03/2003/00068/192
Researcher
N/A
2000 - 2003 Recursos genéticos de Olea europaea L. em Trás-os-Montes e Alto Douro: prospecção, conservação, caracterização de variedades e avaliação do seu potencial agronómico
PIDDAC 153/00
Researcher
1999 - 2000 Estudos das cultivares de Olea europaea L. ‘Negrinha de Freixo’ e ‘Santulhana’ em Trás-os-Montes no âmbito da produção integrada
PIDDAC 130/99
Researcher
1998 - 2000 Caracterização com vista à melhoria das fermentações tradicionais de azeitona de mesa, tipo negra natural da cv. ‘Galega’
PAMAF-IED-6030
Researcher
1999 - 1999 Conservation, characterization, collecte et utilisation des resources genetiques de l`olivier
RESGEN
Researcher
1998 - 1998 Valorização das cultivares de Olea europaea L. ‘Negrinha de Freixo’ (denominação de origem) e ‘Santulhana’ em Trás-os- Montes
PAMAF-IED-2009
Researcher
Outputs

Publications

Book
  1. Silva, S.; Boross, P.; Soares, R.; Coelho, A.V.; Vilas Boas, L.; Bronze, M.R.. Characterization of nüzhenide and related secoiridoids in Olea europea L. seeds using MALDI-TOF mass spectrometry. 2012.
  2. Silva, S.; Gomes, M.L.; Vilas-Boas, L.; Catulo, L.; Peres, C.. Analytical methods for brines and fruits of Olea europaea galega cv. 2002.
  3. Catulo, L.; Leitão, F.; Oliveira, M.M.; Peres, C.; Silva, S.; Gomes, M.L.; Peito, M.A.; Fernandes, I.; Gordo, F.. Table olive fermentation of galega portuguese variety. Microbiological, physico-chemical and sensorial aspects. 2002.
  4. Silva, S.; Gomes, M.L.; Vilas-Boas, L.; Catulo, L.; Peres, C.. Analytical methods for brines and fruits of olea europaea cv. galega. 2002.
Journal article
  1. Serra, Ana Teresa; Silva, Sandra D.; Pleno de Gouveia, Luís; Alexandre, Agostinho M. R. C.; Pereira, Carolina V.; Pereira, Ana Barbara; Partidário, Ana Carvalho; et al. "A Single Dose of Marine Chlorella vulgaris Increases Plasma Concentrations of Lutein, ß-Carotene and Zeaxanthin in Healthy Male Volunteers". Antioxidants 10 8 (2021): 1164. http://dx.doi.org/10.3390/antiox10081164.
    Published • 10.3390/antiox10081164
  2. Brito, C.; Tomás, A.; Silva, S.; Bronze, M.R.; Serra, A.T.; Pojo, M.. "The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models". Molecules (Basel, Switzerland) 26 2 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099901897&partnerID=MN8TOARS.
    10.3390/molecules26020289
  3. Mecha, E.; Feliciano, R.P.; Rodriguez-Mateos, A.; Silva, S.D.; Figueira, M.E.; Vaz Patto, M.C.; Bronze, M.R.. "Human bioavailability of phenolic compounds found in common beans: The use of high-resolution MS to evaluate inter-individual variability". British Journal of Nutrition 123 3 (2020): 273-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078822552&partnerID=MN8TOARS.
    10.1017/S0007114519002836
  4. Silva S; Garcia-Aloy M; Figueira ME; Combet E; Mullen W; Bronze MR. "High Resolution Mass Spectrometric Analysis of Secoiridoids and Metabolites as Biomarkers of Acute Olive Oil Intake-An Approach to Study Interindividual Variability in Humans.". Molecular nutrition & food research (2017): http://europepmc.org/abstract/med/29068138.
    10.1002/mnfr.201700065
  5. Saoudi S; Chammem N; Sifaoui I; Bouassida-Beji M; Jiménez IA; Bazzocchi IL; Silva SD; Hamdi M; Bronze MR. "Influence of Tunisian aromatic plants on the prevention of oxidation in soybean oil under heating and frying conditions.". (2016): http://europepmc.org/abstract/med/27374561.
    10.1016/j.foodchem.2016.05.186
  6. Silva S; Combet E; Figueira ME; Koeck T; Mullen W; Bronze MR. "New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers.". (2015): http://europepmc.org/abstract/med/26186673.
    10.1017/s0029665115002323
  7. Silva S; Sepodes B; Rocha J; Direito R; Fernandes A; Brites D; Freitas M; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.". (2015): http://europepmc.org/abstract/med/25620693.
    10.1016/j.jnutbio.2014.11.011
  8. Silva S; Bronze MR; Figueira ME; Siwy J; Mischak H; Combet E; Mullen W. "Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study.". (2015): http://europepmc.org/abstract/med/25527749.
    10.3945/ajcn.114.094219
  9. Silva, S.; Combet, E.; Figueira, M.E.; Koeck, T.; Mullen, W.; Bronze, M.R.. "New perspectives on bioactivity of olive oil: Evidence from animal models, human interventions and the use of urinary proteomic biomarkers". Proceedings of the Nutrition Society 74 3 (2015): 268-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937549942&partnerID=MN8TOARS.
    10.1017/S0029665115002323
  10. Silva SD; Feliciano RP; Boas LV; Bronze MR. "Application of FTIR-ATR to Moscatel dessert wines for prediction of total phenolic and flavonoid contents and antioxidant capacity.". (2014): http://europepmc.org/abstract/med/24360480.
    10.1016/j.foodchem.2013.11.028
  11. Peres, C.M.; Alves, M.; Hernandez-Mendoza, A.; Moreira, L.; Silva, S.; Bronze, M.R.; Vilas-Boas, L.; Peres, C.; Malcata, F.X.. "Novel isolates of lactobacilli from fermented Portuguese olive as potential probiotics". LWT - Food Science and Technology 59 1 (2014): 234-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903783850&partnerID=MN8TOARS.
    10.1016/j.lwt.2014.03.003
  12. Matias AA; Serra AT; Silva AC; Perdigão R; Ferreira TB; Marcelino I; Silva S; et al. "Portuguese winemaking residues as a potential source of natural anti-adenoviral agents.". (2010): http://europepmc.org/abstract/med/20109126.
    10.3109/09637480903430990
  13. Sandra Silva; Lucília Gomes; Fausto Leitão; Maria Bronze; Ana V. Coelho; Luís Vilas Boas. "Secoiridoids in olive seed: characterization of nüzhenide and 11-methyl oleosides by liquid chromatography with diode array and mass spectrometry". Grasas y Aceites 61 2 (2010): 157-164. https://doi.org/10.3989%2Fgya.087309.
    10.3989/gya.087309
  14. Silva, S.D.; Rosa, N.F.; Ferreira, A.E.; Boas, L.V.; Bronze, M.R.. "Rapid determination of a-tocopherol in vegetable oils by fourier transform infrared spectroscopy". Food Analytical Methods 2 2 (2009): 120-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349117879&partnerID=MN8TOARS.
    10.1007/s12161-008-9047-y
  15. Silva, S.; Gomes, L.; Leitão, F.; Coelho, A.V.; Boas, L.V.. "Phenolic compounds and antioxidant activity of Olea europaea L. Fruits and leaves". Food Science and Technology International 12 5 (2006): 385-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749500977&partnerID=MN8TOARS.
    10.1177/1082013206070166
  16. Bravo, M.N.; Silva, S.; Coelho, A.V.; Boas, L.V.; Bronze, M.R.. "Analysis of phenolic compounds in Muscatel wines produced in Portugal". Analytica Chimica Acta 563 1-2 SPEC. (2006): 84-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645319971&partnerID=MN8TOARS.
    10.1016/j.aca.2005.11.054
  17. Oliveira, M.; Brito, D.; Catulo, L.; Leitäo, F.; Gomes, L.; Silva, S.; Vilas-Boas, L.; et al. "Biotechnology of olive fermentation of 'Galega' Portuguese variety". Grasas y Aceites 55 3 (2004): 219-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-20244383972&partnerID=MN8TOARS.

Other

Other output
  1. Analysis of trans-resveratrol: Comparison of methods and contents in Muscatel fortified wines from Setúbal region in Portugal. 2008. Bravo MN; Feliciano R; Silva S; Coelho AV; Vilas Boas L; Bronze MR. http://europepmc.org/abstract/AGR/IND44119530.
    10.1016/j.jfca.2008.04.007
  2. In vitro evaluation of olive- and grape-based natural extracts as potential preservatives for food. 2008. Serra AnaTeresa; Matias AnaA; Nunes AnaVM; Leitão MC; Brito Dulce; Bronze R; Silva Sandra; et al. http://europepmc.org/abstract/AGR/IND44062025.
    10.1016/j.ifset.2007.07.011
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 A single dose of marine Chlorella vulgaris increases plasma concentration of lutein, ß-carotene and zeaxanthin in a 3 days intervention study with human healthy volunteers EuroCaroten - International Conference on Carotenoid research and applications in agro-food and health. COST ACTION CA15136
COST ACTION CA15136 (Lemesos, Cyprus)
2019/09 High Resolution Mass Spectrometric Analysis of Secoiridoids and Metabolites as Biomarkers of Acute Olive Oil Intake – An Approach to Study Interindividual Variability in Humans Urinomics 2019 – 4th International Caparica Conference on Urine Omics and Translational Nephrology
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia (Caparica, Portugal)
2019/07 Unveiling the benefits of Olive Oil for preventing human chronic diseases Encontro Ciência '19
(Lisboa, Portugal)
2018/09 Perspectives on bioactivity of olive oil 2nd Food Bioactives and Health Conference
(Lisboa, Portugal)
2018/03 FTIR-ATR as a tool to predict chemical parameters in different food samples 1st PortASAP meeting/Cost Action CA16215
Cost Action CA16215 (Porto, Portugal)
2017/05 Bioactivity of olive oil: evidences from animal model to human interventions 4th Annual Conference Interdisciplinary Network on Agro-Food and Forestry
Universidade de Lisboa (Lisboa, Portugal)
2016/10 New approaches on bioactivity of olive oil: evidences from animal model to human interventions 1st International Scientific Meeting on Olive Oil (ISMOO)
(Barcelona, Spain)
2016/01 High Resolution Mass Spectrometry Applied to Study Human Metabolism of Olive Oil Phenolic Compounds XVI Latin-American Congress on Chromatography (XVI COLACRO) & 9th National Meeting on Chromatography (9ENC)
(Lisboa, Portugal)
2015/09 Olive oil phenolic compounds: identification of urinary metabolites using high resolution mass spectrometry 2nd International Caparica Conference on Urine Omics & 2nd International Caparica Conference in Translational Nephrology
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia (Caparica, Portugal)
2015/03/11 Olive oil health benefits – new evidences from animal models and human interventions Scan Seminar
ITQB (Oeiras, Portugal)
2014/07 Health benefits of olive oil consumption: studies on the importance of phenolic compounds in biological activity The Nutrition Society Summer Meeting 2014
Nutrition Society (Glasgow, United Kingdom)
2014/03 Efeito na Saúde do Consumo de Azeite - Ensaio Clínico numa População Escocesa "Noites na Ordem, Farmacêuticos pelo Mundo"
Ordem dos Farmacêuticos (Lisboa, Portugal)
2006/05 Análise de compostos fenólicos em amostras de cultivares de oliveira (Olea europaea L.) por HPLC/MS Ciclo de Seminários de Farmácia – Análises Bromatológicas
Universidade Lusófona (Lisboa, Portugal)
2003/10 Análise de Compostos Fenólicos em Azeitonas e Azeites de Trás-os-Montes e Alto Douro III Simpósio Nacional de Olivicultura
(Castelo Branco, Portugal)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2002 - 2009 Métodos Instrumentais de Análise/Espetroscopia de Absorção Atómica, Cromatografia, Eletroforese Capilar, Espetroscopia de Infravermelho Técnico de Laboratório em Análises de Alimentos e Análises Ambientais (Curso de Especialização Tecnológica) Universidade Católica Portuguesa Instituto de Ciências da Saúde, Portugal
Distinctions

Award

2020 Menção Honrosa
Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2019 Melhor Poster
Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2016 Melhor Poster
Nutrition Society, United Kingdom

Other distinction

2014 Top 4 winner of Postgraduate Competition
2014 Prémio Inovação
Ordem dos Farmaceuticos, Portugal