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Romina Guedes has a PhD in Pharmacy – specialty: Pharmaceutical Chemistry and Therapeutics (2019; University of Lisbon – Faculty of Pharmacy; collaboration with University of Coimbra – Faculty of Pharmacy and with the University of Ferrara - Italy), a Masters degree in Pharmaceutical and Therapeutic Chemistry (2017; University of Coimbra – Faculty of Pharmacy) and also an Integrated Masters degree in Pharmaceutical Sciences (2009; University of Coimbra – Faculty of Pharmacy). Currently, Romina is a researcher of the Center for Neurosciences and Cell Biology (University of Coimbra) and Invited Assistant Professor (of Toxicology and Toxicological Analysis) at the University of Coimbra – Faculty of Pharmacy. The main target area of her multidisciplinary research has been the Oncology field (in particular the Ubiquitin Proteasome System, namely the proteasome and deubiquinating enzyme USP7), but also has collaborations in Respiratory, Infectious and Metabolic diseases. The main achievements of her work include the finding of new scaffolds of proteasome inhibitors, and also chemical patterns that can be used in future drug discovery projects by research groups all over the world in order to speed up this process. Romina has several publications in international journals, and also several poster and oral communications. She has received 2 awards for best oral communication and also a merit scholarship from the University of Coimbra. Moreover, she has performed peer review of manuscripts for publication.
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Identification

Personal identification

Full name
Romina Guedes

Citation names

  • Guedes, Romina Aguiar
  • Guedes, Romina A

Author identifiers

Ciência ID
071D-9A56-51C5
ORCID iD
0000-0002-4397-7968

Email addresses

  • rominaguedes@ff.uc.pt (Professional)

Addresses

  • Faculdade de Farmácia da Universidade de Coimbra. Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3030-548, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2015/03/02 - 2019/12/17
Concluded
 Doutoramento em Farmácia (Doutoramento)
Major in Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Targeting the proteasome in anticancer therapy by a computational based drug discovery approach" (THESIS/DISSERTATION)
 Aprovada por unanimidade com distinção e louvor
2013
Concluded
 Mestrado em Química Farmacêutica Industrial (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Virtual screening e avaliação biológica de novos inibidores do proteassoma" (THESIS/DISSERTATION)
 17 valores
2009
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2021/09/01 - Current Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019/06/27 - 2019/12/31 Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/02/14 - 2023/08/31 Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2015/03/02 - 2019/12/17 PhD candidate Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 PhD student CNC.IBILI, Portugal
2018 - 2018 PhD student Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016 - 2017 PhD student CNC.IBILI, Portugal
2015 - 2017 PhD student Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Grant

Designation Funders
2015/03/02 - 2019/03/01 Targeting the proteasome in anticancer therapy through a computational based drug discovery approach
SFRH/BD/104441/2014
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/06/01 - 2019/12/31 UID/DTP/04138/2019
UID/DTP/04138/2019
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2015/06/01 - 2019/12/31 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/05/01 - 2019/12/31 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Researcher
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. "New Anticancer Proteasome Inhibitors: Computer-aided Drug Design, Biological Evaluation and Statistical Analysis of Molecular Descriptors". Paper presented in 11th iMed.Ulisboa Postgraduate Students Meeting, 2019.
  2. "Finding new molecules to inhibit the 20S proteasome in anticancer therapy: computer-aided drug design and biological evaluation". Paper presented in 5th EFMC Young Medicinal Chemist Symposium XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018), 2018.
  3. "New molecules to inhibit the 20S proteasome in anticancer therapy: computer-aided drug design methodologies and biological evaluation". Paper presented in XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018), 2018.
  4. "New molecules to inhibit the Human 20S proteasome in Anticancer Therapy: computer-aided drug design methodologies and biological evaluation of the compounds". Paper presented in 10th iMed.Ulisboa Postgraduate Students Meeting, 2018.
  5. "New molecules to inhibit the 20S proteasome: computer-aided drug design methodologies and biological evaluation". Paper presented in 3º Encontro do Colégio da Química da Universidade de Lisboa, 2018.
  6. "Characterization of the membrane permeability of different proteasome inhibitors using molecular dynamics methods". Paper presented in 12º Encontro Nacional de Química Orgânica / 5º Encontro Nacional de Química Terapêutica, 2018.
  7. "The 20S proteasome as a target: finding new inhibitors through computer-aided drug design methodologies and biological evaluation of the selected compounds". Paper presented in 2º Encontro do Colégio da Química da Universidade de Lisboa, 2017.
  8. "Targeting the human 20S proteasome: finding new inhibitors through a computational-based drug discovery approach and biological evaluation of the selected compounds". Paper presented in XXV Encontro Nacional da Sociedade Portuguesa de Química, 2017.
  9. "Targeting the human 20S proteasome: finding new inhibitors through a CADD approach and biological evaluation of the compounds". Paper presented in 9th iMed.Ulisboa Postgraduate Students Meeting, 2017.
  10. "Targeting 20S proteasome through a computational-based drug discovery approach to find new inhibitors". Paper presented in I Congresso de Química Computacional – Universidade de Évora, 2016.
  11. "Discovery of 20S proteasome inhibitors: A strategy to anticancer therapy". Paper presented in Congresso de Química Orgânica e Química Terapêutica, 2015.
  12. "Targeting 20S proteasome activity for anticancer therapy". Paper presented in 7th iMed.Ulisboa Postgraduate Students Meeting, 2015.
Journal article
  1. Pedro M. P. Fernandes; Romina A. Guedes; Bruno L. Victor; Jorge A. R. Salvador; Rita C. Guedes. "Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome". Frontiers in Chemistry (2024): http://dx.doi.org/10.3389/fchem.2023.1322628.
    10.3389/fchem.2023.1322628
  2. Tiago O. Pereira; Maryam Abbasi; Rita I. Oliveira; Romina A. Guedes; Jorge A. R. Salvador; Joel P. Arrais. "Artificial intelligence for prediction of biological activities and generation of molecular hits using stereochemical information". Journal of Computer-Aided Molecular Design (2023): http://dx.doi.org/10.1007/s10822-023-00539-9.
    10.1007/s10822-023-00539-9
  3. Romina A. Guedes; Jorge H. Grilo; Andreia N. Carvalho; Pedro M. P. Fernandes; Ana S. Ressurreição; Vanessa Brito; Adriana O. Santos; et al. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16081096.
    10.3390/ph16081096
  4. Celso Alves; Joana Silva; Susete Pintéus; Romina A. Guedes; Rita C. Guedes; Rebeca Alvariño; Rafaela Freitas; et al. "Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action". Marine Drugs (2022): https://doi.org/10.3390/md20100652.
    10.3390/md20100652
  5. Rita I. Oliveira; Romina A. Guedes; Jorge A. R. Salvador. "Highlights in USP7 inhibitors for cancer treatment". Frontiers in Chemistry (2022): http://dx.doi.org/10.3389/fchem.2022.1005727.
    10.3389/fchem.2022.1005727
  6. Tiago Pereira; Maryam Abbasi; Rita I Oliveira; Romina A Guedes; Jorge A R Salvador; Joel P Arrais. "Deep generative model for therapeutic targets using transcriptomic disease-associated data—USP7 case study". Briefings in Bioinformatics (2022): http://dx.doi.org/10.1093/bib/bbac270.
    10.1093/bib/bbac270
  7. Celso Alves; Joana Silva; Marta B. Afonso; Romina A. Guedes; Rita C. Guedes; Rebeca Alvariño; Susete Pinteus; et al. "Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models". Biomedicine & Pharmacotherapy (2022): http://dx.doi.org/10.1016/j.biopha.2022.112886.
    10.1016/j.biopha.2022.112886
  8. Carlota Leonardo-Sousa; Andreia Neves Carvalho; Romina A. Guedes; Pedro M. P. Fernandes; Natália Aniceto; Jorge A. R. Salvador; Maria João Gama; Rita C. Guedes. "Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance". Molecules 27 7 (2022): 2201-2201. https://doi.org/10.3390/molecules27072201.
    10.3390/molecules27072201
  9. Guedes, Romina A; Aniceto, Natália; Marina Alexandra Pedro Andrade; Jorge A. R. Salvador, Salvador, J.; Guedes, Rita C.. "Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design". International Journal of Molecular Sciences 20 21 (2019): 5326. http://dx.doi.org/10.3390/ijms20215326.
    Published • 10.3390/ijms20215326
  10. Guedes, Romina A; Serra, Patrícia; Jorge A. R. Salvador, Salvador, J.; Guedes, Rita C.. "Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview". Molecules 21 7 (2016): 927. http://dx.doi.org/10.3390/molecules21070927.
    Published • 10.3390/molecules21070927
  11. Carreiro, E.P.; Louro, P.; Adriano, G.; Guedes, R.A.; Vannuchi, N.; Costa, A.R.; Antunes, C.M.M.; Guedes, R.C.; Burke, A.J.. "3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: Inhibition of rat intestinal a-glucosidase". Bioorganic Chemistry 54 (2014): 81-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901282250&partnerID=MN8TOARS.
    10.1016/j.bioorg.2014.04.007
  12. Lucas, Susana D.; Gonçalves, Lídia M.; Carvalho, Luís A. R.; Correia, Henrique F.; Da Costa, Eduardo M. R.; Guedes, Romina A.; Moreira, Rui; Guedes, Rita C.. "Optimization of O3-Acyl Kojic Acid Derivatives as Potent and Selective Human Neutrophil Elastase Inhibitors". Journal of Medicinal Chemistry 56 23 (2013): 9802-9806. https://pubs.acs.org/doi/10.1021/jm4011725.
    Published • 10.1021/jm4011725
Thesis / Dissertation
  1. Guedes, Romina Aguiar. "Targeting the proteasome in anticance therapy by a computational based drug discovery approach". PhD, Universidade de Lisboa Faculdade de Farmácia, 2019. http://hdl.handle.net/10451/42785.
  2. Guedes, Rita Alexandra Cardoso Nascimento; Salvador, Jorge António Ribeiro. "Virtual screening e avaliação biológica de novos inibidores do proteassoma". Master, 2015. http://hdl.handle.net/10316/30395.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/01/19 Finding new inhibitors of the 20S proteasome: computer-aided drug design methodologies and biological evaluation of the selected compounds 12º Encontro Nacional de Química Orgânica / 5º Encontro Nacional de Química Terapêutica
(Portugal)
2017/12/04 The 20S proteasome as a target: finding new inhibitors through computer-aided drug design methodologies and biological evaluation of the selected compounds 2º Encontro do Colégio da Química da Universidade de Lisboa – Lisboa
2016/07/14 Targeting 20S proteasome through a computational-based drug discovery approach 8th iMed.Ulisboa Postgraduate Students Meeting
(Portugal)
2016/06/22 Targeting 20S proteasome through a computational-based drug discovery approach to find new inhibitors I Congresso de Química Computacional – Universidade de Évora
(Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/01/03 - 2017/07/14 9th iMed.Ulisboa Postgraduate Students Meeting Member of the post graduate students comission. Main responsabilities: selection of the speakers, schedule organization, management of the catering service, management of administartive services, finding of sponsors for the event. (2017/07/13 - 2017/07/14) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/01/03 - 2016/07/15 8th iMed.Ulisboa Postgraduate Students Meeting. Main responsabilities: selection of the speakers, schedule organization, management of the catering service, management of administartive services, finding of sponsors for the event. (2016/07/14 - 2016/07/15)
Congress (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/03/01 - 2016/04/06 Statistics in scientific research (2016/03/31 - 2016/04/06)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/03/15 - 2015/07/16 7th iMed.Ulisboa Postgraduate Students Meeting. Member of the post graduate students comission. Main responsabilities: selection of the speakers, schedule organization, management of the catering service, management of administartive services, finding of sponsors for the event. (2015/07/15 - 2015/07/16)
Congress (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/14 - Current Toxicologia e análises toxicológicas Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/02/14 - Current Toxicologia analítica Ciências Bioanalíticas (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2018/04/12 - 2020/04/27 Computational Biology and Chemistry Elsevier
Distinctions

Other distinction

2018 Best oral communication of Medicinal Chemistry (12º ENQO, 5º ENQT - Coimbra)
Sociedade Portuguesa de Quimica, Portugal
2017 Award for oral communication
Universidade de Lisboa, Portugal
2015 Bolsa de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
2009 Bolsa de mérito por pertencer aos 3% dos melhores alunos de Ciências Farmacêuticas.
Universidade de Coimbra Faculdade de Farmácia, Portugal