Personal identification

Full name

Alexandra Ferreira Faustino

Citation names

• Faustino, Alexandra

Author identifiers

Ciência ID

051C-220E-D733

ORCID iD

0000-0001-9175-5561

Email addresses

• alexandra.faustino@itqb.unl.pt (Professional)

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

	Degree	Classification
2015/01 - 2020/05 Concluded	Mechanisms of Disease and Regenerative Medicine (ProRegeM) (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal "Role of Arl13b in breast cancer cell migration and invasion" (THESIS/DISSERTATION)	Unanimously with Very Good with Distinction and Honours
2013/09 - 2014/12 Concluded	Biomedical Sciences (Mestrado) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal "Defining the role of NatC dependent N-terminal acetylation in Drosophila fertility" (THESIS/DISSERTATION)	17
2003/09 - 2007/07 Concluded	Biochemistry (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Development of novel lipid-based formulations for application in antitumor gene therapy approaches" (THESIS/DISSERTATION)	15

Others

	Category Host institution	Employer
2024/01 - Current	Grant Manager	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/10 - 2023/12	Support to the LS4FUTURE Coordination Office	LS4FUTURE/NMS, Portugal
2022/01 - 2022/12	Postdoctoral Fellowship	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01 - 2020/05	Research Fellowhip	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2015/01 - 2018/12	PhD Research Fellowhip	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014/10 - 2014/12	Research Fellowship	Universidade do Algarve - Centro de Biomedicina Molecular e Estrutural, Portugal
	Universidade do Algarve - Centro de Biomedicina Molecular e Estrutural, Portugal
2012/01 - 2014/09	Research Fellowhip	Instituto Gulbenkian de Ciência, Portugal
	Instituto Gulbenkian de Ciência, Portugal (...)
2007/12 - 2011/12	Research Fellowhip	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Grant

	Designation	Funders
2016/04/01 - 2019/09/30	Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression. PTDC/BIM-MEC/4905/2014 PhD Student Fellow iNOVA4Health, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2015/01/01 - 2018/12/31	Role of Arl13b in tumor progression and metastization. PD/BD/105898/2014 PhD Student Fellow Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/10/01 - 2010/12/31	Caracterização molecular e funcional da via do mTOR no carcinoma papilar da tireóide PTDC/SAU-OBD/69787/2006 Integration into Research Grant Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Publications

Conference paper	Vinagre, João; Pópulo, Helena; Faustino, Alexandra; Tavares, Sandra; Prof. José Manuel Lopes; Prof. Paula Soares. "BRAF and GNAQ mutation cellular effects in mTOR pathway activation in human cells (BRAF mutational status is a candidate biomarker for response to mTOR inhibitors therapy)". Paper presented in 23rd European Congress of Pathology, Helsinki, 2011. Published
Conference poster	Faustino, Alexandra; Casalou, Cristina; Barral, Duarte C.. "A new role for Arl13b in the regulation of cell-cell and cell-extracellular matrix adhesion". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Faustino, Alexandra; Casalou, Cristina; Serpa, Jacinta; Barral, Duarte C.. "A new role for Arl13b in cancer cell migration and invasion". Paper presented in EMBO Young Scientists' Forum 2016 (EYSF2016), 2016. Pópulo, Helena; Faustino, Alexandra; Tavares, Sandra; Nunes, Joana B; Lopes, José; Soares, Paula. "Differential activation of the mTOR pathway in BRAF and GNAQ human transformed cells". Paper presented in XXI Porto Cancer Meeting: Metabolism and Cancer: from etiopathogenesis to therapy, 2012. Vinagre, João; Celestino, Ricardo; Gouveia, António; Lima, Jorge; Faustino, Alexandra; Soares, Paula; Lopes, José Manuel. "A novel germline SDHB mutation in a GIST patient without associated paraganglioma or pheochromocytoma". Paper presented in 23rd European Congress of Pathology of the European Society of Pathology, Helsinki, Finland, 2011. Pópulo, Helena; Faustino, Alexandra; Tavares, Sandra; Lopes, José; Soares, Paula. "Evaluation of melanoma cell lines sensitivity to RAD001 treatment". Paper presented in XX Porto Cancer Meeting: Drug Resistance in Cancer: from biology to molecular targets and drugs, 2011. Faustino, Alexandra; Rocha, Ana Sofia; Pópulo, Helena; Soares, Paula; Sobrinho-Simoes, Manuel. "Overactivation of the PI3K/AKT/mTOR pathway is observed in thyroid benign diseases". Paper presented in 34th Annual Meeting of the European Thyroid Association (ETA), 2009. Faustino, Alexandra; Rocha, Ana Sofia; Pópulo, Helena; Soares, Paula. "What can we learn from animal models that can be useful in human pathology?". Paper presented in Centro de Investigaciones Oncológicas (CNIO) Cancer Conference: "SIGNALLING UPSTREAM OF mTOR"/Program, 2008.
Journal article	Sylvia Varland; Rui Duarte Silva; Ine Kjosås; Alexandra Faustino; Annelies Bogaert; Maximilian Billmann; Hadi Boukhatmi; et al. "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity". Nature Communications (2023): https://doi.org/10.1038/s41467-023-42342-y. 10.1038/s41467-023-42342-y Cristina Casalou; Alexandra Faustino; Fernanda Silva; Inês C. Ferreira; Daniela Vaqueirinho; Andreia Ferreira; Pedro Castanheira; et al. "Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling". Cancers 11 10 (2019): 1461-1461. https://doi.org/10.3390/cancers11101461. 10.3390/cancers11101461 Rathore, Om Singh; Faustino, Alexandra; Prudêncio, Pedro; Van Damme, Petra; Cox, Cymon J.; Martinho, Rui Gonçalo. "Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep21304. Published • 10.1038/srep21304 Casalou, C.; Faustino, A.; Barral, D.C.. "Arf proteins in cancer cell migration". Small GTPases 7 4 (2016): 270-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988596463&partnerID=MN8TOARS. 10.1080/21541248.2016.1228792 Celestino, R.; Lima, J.; Faustino, A.; Vinagre, J.; Maximo, V.; Gouveia, A.; Soares, P.; Lopes, J.M.. "Molecular alterations and expression of succinate dehydrogenase complex in wild-type kit/pdgfra/braf gastrointestinal stromal tumors". European Journal of Human Genetics 21 5 (2013): 503-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876668234&partnerID=MN8TOARS. 10.1038/ejhg.2012.205 Pópulo, H.; Tavares, S.; Faustino, A.; Nunes, J.B.; Lopes, J.M.; Soares, P.. "GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells". PeerJ 2013 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885166168&partnerID=MN8TOARS. 10.7717/peerj.104 Celestino, R.; Lima, J.; Faustino, A.; Máximo, V.; Gouveia, A.; Vinagre, J.; Soares, P.; Lopes, J.M.. "A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad". Familial Cancer 11 2 (2012): 189-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864662004&partnerID=MN8TOARS. 10.1007/s10689-011-9499-x Faustino, A.; Couto, J.P.; Pópulo, H.; Rocha, A.S.; Pardal, F.; Cameselle-Teijeiro, J.M.; Lopes, J.M.; Sobrinho-Simões, M.; Soares, P.. "mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma". Journal of Clinical Endocrinology and Metabolism 97 7 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863566153&partnerID=MN8TOARS. 10.1210/jc.2011-2748 Pópulo, H.; Soares, P.; Faustino, A.; Rocha, A.S.; Silva, P.; Azevedo, F.; Lopes, J.M.. "mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics". Pigment Cell and Melanoma Research 24 1 (2011): 254-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651444805&partnerID=MN8TOARS. 10.1111/j.1755-148X.2010.00796.x Faneca, H.; Faustino, A.; Pedroso de Lima, M.C.. "Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes". Journal of Controlled Release 126 2 (2008): 175-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749101958&partnerID=MN8TOARS. 10.1016/j.jconrel.2007.12.005
Thesis / Dissertation	Faustino, Alexandra Ferreira. "Role of arl13b in breast cancer cell migration and invasion". PhD, 2020. http://hdl.handle.net/10362/98646. Faustino, Alexandra Ferreira. "Defining the role of NatC dependent N-terminal acetylation in Drosophila fertility". Master, 2014. http://hdl.handle.net/10400.1/8381.