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Identification

Personal identification

Full name
Rafael Valente Fidalgo Ramos Roque

Author identifiers

Ciência ID
051B-EAEE-FD29
ORCID iD
0000-0002-9027-9310
Education
Degree Classification
2015
Concluded
 Grau de Consultor (Diploma de especialização)
Major in Neurologia
Ordem dos Médicos, Portugal
2011
Concluded
 Ciclo de Estudos Especiais em Neuropatologia (Título de especialista)
Ordem dos Médicos, Portugal
2007
Concluded
 Especialista em Neurologia (Título de especialista)
Major in Neurologia
Ordem dos Médicos, Portugal
1993 - 1999/11
Concluded
 Medicina (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2003 - 2022 Invited Assistant (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Other Careers

Category
Host institution 		Employer
2016 - Current Assistente graduado (Médica) Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Serviço de Neurologia, Laboratório de Neuropatologia, Portugal
2008 - 2013 Assistente (Médica) Centro Hospitalar de Lisboa Central EPE, Portugal
2002 - 2007 Interno (Médica) Centro Hospitalar de Lisboa Central EPE, Portugal

Positions / Appointments

Category
Host institution 		Employer
2013 - 2015 Medical Affairs Manager Sanofi Genzyme Portugal, Portugal

Others

Category
Host institution 		Employer
2022 - Current Director do Laboratório de Neuropatologia, Serviço de Neurologia Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Projects

Contract

Designation Funders
2023/01/01 - 2025/12/31 Explorando UBE2C como marcador de prognóstico e alvo terapêutico em doentes com metástases cerebrais
2022.08774.PTDC
10.54499/2022.08774.PTDC
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Centro Nacional de Investigaciones Oncológicas, Spain
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Paisana, Eunice; Cascão, Rita; Custodia, Carlos; Qin, Nan; Picard, Daniel; David Pauck; Carvalho, Tânia; et al. "Targeting the PI3K-mTOR pathway to treat UBE2C-driven brain metastases". Paper presented in Joint SNO/ASNO Conference on CNS Clinical Trials and Brain Metastases, 2022.
Journal article
  1. Costa, Filipa; Campanilho-Marques, Raquel; Dourado, Eduardo; Bandeira, Matilde; Roque, Rafael; Fonseca, João Eurico; Saraiva, Fernando. "Efficacy and safety of ultrasound-guided needle muscle biopsy in the diagnosis of idiopathic inflammatory myopathies". Rheumatology (2025): https://doi.org/10.1093/rheumatology/keaf241.
    10.1093/rheumatology/keaf241
  2. Paisana, Eunice; Cascão, Rita; Alvoeiro, Magda; Félix, Francisco; Martins, Guilherme; Guerreiro, Carla; Roque, Rafael; et al. "Immunotherapy in lung cancer brain metastases". npj Precision Oncology 9 1 (2025): https://doi.org/10.1038/s41698-025-00901-0.
    10.1038/s41698-025-00901-0
  3. Martins, Joana; Seixas, Ana B; Bartikian, Mickael; Marto, Erica; Roque, Rafael; Simas, Nuno. "Synchronous Intercostal Nerve Schwannomas: A Rare Cause of Chest Wall Pain". Cureus (2025): https://doi.org/10.7759/cureus.78725.
    10.7759/cureus.78725
  4. Santos Silva, Cláudia; Nunes Vicente, Beatriz; Martins, Bárbara; Fonseca, Ana Cláudia; Coelho, Pedro; Roque, Rafael; Cota de Medeiros, Fábio; Oliveira Santos, Miguel; de Carvalho, Mamede. "Ptosis in human immunodeficiency virus-infected patients under long-term antiretroviral treatment". Clinical Neurology and Neurosurgery 249 (2025): 108690. https://doi.org/10.1016/j.clineuro.2024.108690.
    10.1016/j.clineuro.2024.108690
  5. Vidal, Isabel; Antunes, Ana Patrícia; Morgado, Carlos; Simas, Nuno; Roque, Rafael; Albuquerque, Luísa. "Pearls & Oy-sters: A Challenging Optic Neuropathy—What Not to Miss in Optic Nerve Sheath Enhancement". Neurology 102 11 (2024): https://doi.org/10.1212/wnl.0000000000209494.
    10.1212/wnl.0000000000209494
  6. Picard, Daniel; Felsberg, Jörg; Langini, Maike; Stachura, Pawel; Qin, Nan; Macas, Jadranka; Reiss, Yvonne; et al. "Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma". Acta Neuropathologica 146 4 (2023): 551-564. https://doi.org/10.1007/s00401-023-02626-5.
    10.1007/s00401-023-02626-5
  7. Coelho, Pedro; Madureira, João; Franco, Ana; Peralta, Ana Rita; Bentes, Carla; Campos, Alexandre Rainha; Anink, Jasper; et al. "Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study". European Journal of Neurology 30 10 (2023): 2999-3007. https://doi.org/10.1111/ene.15963.
    10.1111/ene.15963
  8. Nunes, Sofia; Faria, Claudia C.; Pimentel, José; Roque, Rafael; Alaiz, Helena; Salazar, Isabel; Pereira, Teresa; Ferreira, Filipa; Roque, Lúcia. "Medulloblastoma Development in a Patient with a Constitutional Balanced t(5;22)(q35.1;q11.2) Involving the NF2 Gene". Case Reports in Oncology (2023): 36-44. https://doi.org/10.1159/000527564.
    10.1159/000527564
  9. Rachão, Augusto; Ferro, Margarida; Roque, Rafael; Campos, Alexandre Rainha; Pimentel, José. "A case of trigeminal malignant melanotic nerve sheath tumor in the wide spectrum of melanotic and nerve sheath tumors". Neuropathology 43 4 (2023): 345-348. https://doi.org/10.1111/neup.12891.
    10.1111/neup.12891
  10. Paisana, Eunice; Cascão, Rita; Custódia, Carlos; Qin, Nan; Picard, Daniel; Pauck, David; Carvalho, Tânia; et al. "UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease". Neuro-Oncology Advances 5 1 (2023): https://doi.org/10.1093/noajnl/vdad048.
    10.1093/noajnl/vdad048
  11. Oliveira, Renato; Sotero, Filipa Dourado; Coelho, Joana; Roque, Rafael; Moreno, Teresa; Oliveira Santos, Miguel. "Inherited myopathies in patients from Sub-Saharan Africa: Results from a retrospective cohort". Journal of Clinical Neuroscience 106 (2022): 43-48. https://doi.org/10.1016/j.jocn.2022.10.007.
    10.1016/j.jocn.2022.10.007
  12. Faria, Claudia C.; Cascão, Rita; Custódia, Carlos; Paisana, Eunice; Carvalho, Tânia; Pereira, Pedro; Roque, Rafael; et al. "Patient-derived models of brain metastases recapitulate human disseminated disease". Cell Reports Medicine 3 5 (2022): 100623. https://doi.org/10.1016/j.xcrm.2022.100623.
    10.1016/j.xcrm.2022.100623
  13. Conde, João; Pumroy, Ruth A.; Baker, Charlotte; Rodrigues, Tiago; Guerreiro, Ana; Sousa, Bárbara B.; Marques, Marta C.; et al. "Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression". ACS Central Science 7 5 (2021): 868-881. https://doi.org/10.1021/acscentsci.1c00070.
    10.1021/acscentsci.1c00070
  14. Grenho Rodrigues, Sofia; Silva, Daniela; Machado, Manuel; Roque, Rafael; Pimentel, José. "Rendimiento diagnóstico de las biopsias musculares en la población pediátrica: experiencia de un centro terciario". Revista de Neurología 72 08 (2021): 283. https://doi.org/10.33588/rn.7208.2020596.
    10.33588/rn.7208.2020596
  15. Oliveira Santos, Miguel; Coelho, Pedro; Roque, Rafael; Conceição, Isabel. "Very late-onset limb-girdle muscular dystrophy type 2D: A milder form with a normal muscle biopsy". Journal of Clinical Neuroscience 72 (2020): 471-473. https://doi.org/10.1016/j.jocn.2019.12.003.
    10.1016/j.jocn.2019.12.003
  16. Pimentel, José; Roque, Rafael; Sá, Manuel Cunha e. "Focal cerebral accumulation of corpora amylacea". Clinical Neuropathology 39 01 (2020): 46-47. https://doi.org/10.5414/np301201.
    10.5414/np301201
  17. Falcão de Campos, Catarina; Oliveira Santos, Miguel; Roque, Rafael; Conceição, Isabel; de Carvalho, Mamede. "Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands". Case Reports in Neurological Medicine 2019 (2019): 1-4. https://doi.org/10.1155/2019/5976410.
    10.1155/2019/5976410
  18. Meira, Bruna; Roque, Rafael; Pinto, Miguel; Caetano, André. "Late-onset presentation of POLG1-associated mitochondrial disease". BMJ Case Reports 12 3 (2019): e228482. https://doi.org/10.1136/bcr-2018-228482.
    10.1136/bcr-2018-228482
  19. Pimentel, José; Afonso, Ana; Roque, Rafael; Farias, João Paulo. "A 82-Year-Old Man with an Extra-Axial Frontal Mass". Brain Pathology 29 2 (2019): 307-308. https://doi.org/10.1111/bpa.12707.
    10.1111/bpa.12707
  20. Maia, B; Roque, Rafael; Amaral-Silva, A; Lourenço, S; Bento, L; Alcântara, J. "Predicting Outcome after Cardiopulmonary Arrest in Therapeutic Hypothermia Patients: Clinical, Electrophysiological and Imaging Prognosticators". Acta Médica Portuguesa 26 (2013): 93-97.
    Open access • 10.20344/amp.203
  21. Sena, A.; Couderc, R.; Ferret-Sena, V.; Pedrosa, R.; Andrade, M. L.; Araujo, C.; Roque, Rafael; Cascais, M. J.; Morais, M. G.. "Apolipoprotein E polymorphism interacts with cigarette smoking in progression of multiple sclerosis". European Journal of Neurology 16 7 (2009): 832-837. https://doi.org/10.1111/j.1468-1331.2009.02603.x.
    10.1111/j.1468-1331.2009.02603.x
  22. Sena, A; Pedrosa, R; Ferret-Sena, V; Cascais, MJ; Roque, Rafael; Araújo, C; Couderc, R. "Interferon ß therapy increases serum ferritin levels in patients with relapsing-remitting multiple sclerosis". Multiple Sclerosis Journal 14 6 (2008): 857-859. https://doi.org/10.1177/1352458508089687.
    10.1177/1352458508089687
Newspaper article
  1. Santos, Mónica; Roque, Rafael; Rainha Campos, Alexandre; Albuquerque, Luísa; Pimentel, José. "Impact of brain biopsy on management of nonneoplastic brain disease", Brain and Spine, 2022, https://doi.org/10.1016/j.bas.2022.100863.
    10.1016/j.bas.2022.100863