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Elisabete Ferreiro is currently an assistant researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, integrated in the group MitoXT - Mitochondrial Toxicology and Experimental Therapeutics, headed by Dr.Paulo Oliveira. Her main expertise area is in neuroscience and cell biology. She graduated in Biology from the University of Coimbra (UC), in 2002, and completed her PhD degree in Biology, also from UC, in 2008. Her PhD works led to the thesis 'Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer¿s disease and Prion disorders'. During her PhD works, E. Ferreiro demonstrated the existence of endoplasmic reticulum (ER) stress as a major contribution for cell death induced by the amyloid beta (Abeta) peptide and PrP106¿126, in both Alzheimer's disease and Prion disorders. Besides, she further showed the relevance of the communication between the ER and the mitochondria for apopotic pathway. In 2008, E. Ferreiro started her post-doc research studies focused on identifying mechanisms involved in Alzheimer's disease (AD) and explore hippocampal adult neurogenesis along with signalling pathways with potential to improve upon it. In 2013, she initiated a second postdoctoral program (Center for Neuroscience and Cell Biology, University of Coimbra). During this period Elisabete Ferreiro studied the mitochondrial control of NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons, the positive value of Coriolus versicolor biomass in dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus and also evaluated whether hyperglycemia enhances Alzheimer´s disease pathology by perturbing adult hippocampal neurogenesis. In 2017 she spent 6 months at the Achucarro Basque Center (Spain), where she extended her knowledge on hippocampal neurogenesis, stem cells and consolidate her collaborations with experts in the field. Currently, she is interested in developing new therapeutic strategies and create personalized medicine platforms for Amyotrophic lateral sclerosis (ALS). In more detail, she is conducting research as principal investigator of funded projects to develop a innovative personalized medicine platform for ALS, based on human neuronal cell differentiated from urine-derived stem cells isolated from ALS patients' urine and test several drugs as potential therapeutic treatment of this disease. E. Ferreiro has been active in European networks, such as, COST action BM1402, As a result of her research activity, she has published 42 scientific papers in international peer reviewed journals, with over 3140 citations, an h index of 28 an i10 index of 33 and an accumulated impact factor of 152.375. She is currently the principal investigator of two ongoing projects with a total budget of 965,367.16 Eur.
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Identification

Personal identification

Full name
Elisabete Ferreiro

Citation names

  • Ferreiro, Elisabete

Author identifiers

Ciência ID
031C-DE55-FA39
ORCID iD
0000-0002-1200-4602

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010/04/19 - 2010/04/30
Concluded
 Course in Laboratorial Animal Science (Pós-Graduação)
Direcção-Geral de Alimentação e Veterinária, Portugal
2008
Concluded
 Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
""Cross-talk" entre o retículo endoplasmático e a mitocôndria na neurotoxicidade dos peptídeos beta-amilóide e do prião. Implicação para a etiopatogenia da doença de Alzheimer e das Encefalopatias Espongiformes" (THESIS/DISSERTATION)
 Approved with praise and distinction by unanimity
2002
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"-" (THESIS/DISSERTATION)
 Bom (15 valores)
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - Current Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/10/01 - 2019/02/28 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/04/01 - 2017/09/30 Visiting Researcher (Research) Universidad del Pais Vasco Centro Achucarro, Spain
Universidad del Pais Vasco Centro Achucarro, Spain

Others

Category
Host institution 		Employer
2003/10/01 - 2008/01/31 PhD fellow Fundação para a Ciência e a Tecnologia, Portugal
Projects

Grant

Designation Funders
2016/06/01 - 2019/02/28 Beta catenin as modulator of neurogenesis and memory enhancer in diabetic-like Alzheimer´s disease mouse model
SFRH / BPD / 86551 / 2012
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2016/05/30 Defining the role of NMDA receptors on hippocampal neurogenesis in a transgenic mice model of Alzheimer's disease under hyperglycemia
SFRH / BPD / 86551 / 2012
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2015/09/30 Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory
EXPL/NEU-SCC/1193/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/10 - 2012/05 Interplay between vascular degeneration and hippocampal neurogenesis in Alzheimer's disease: the role of amyloid-ß-induced ER stress
SFRH/BPD/4336/2008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/10 - 2008/01 Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides: implications for the etiopathogenesis of Alzheimer's disease and prion disorders
SFRH/BD/14108/2003
PhD Student Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2024/01/01 - 2026/12/29 Cooperation and technological transfer for the development of a new platform precision medicine for Amyotrophic Lateral Sclerosis
361_Cross-3DTool-4ALS_3_P
Principal investigator
Universidade de Coimbra, Portugal

Universidad de Salamanca, Spain
European Regional Development Fund
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/03/01 - 2025/02/28 Modulation of adult hippocampal neurogenic reserve for the prevention of cognitive decline in diabetic-like Alzheimer´s disease
CEECIND/00322/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/15 - 2025/01/14 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/02 - 2023/07/01 BraveHEART: Improvig Nature by Addressing Bioactive Dietary Polyphenols to Mitochondria for the Protection of Cardiac Complications in Non-Alcoholic Fatty Liver Disease
EXPL/BIA-BQM/1361/2021
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Mitochondria as potential drivers of sex-specific microglia dysfunctional remodelling and anxiety caused by prenatal stress
EXPL/MED-NEU/1002/2021
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis
EXPL/BTM-TEC/1407/2021
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/03/01 - 2021/11/01 Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype
PTDC/MED-FAR/29391/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2019/12/31 The influence of maternal bonding in neuroimmune synaptic sculpting
264/2016
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação Bial
Concluded
2016/01/01 - 2017/01/01 Modified hippocampal neurogenesis and cognitive function in a mouse model of Alzheimers disease subjected to chronic hyperglycemia
FMUC-BST-2016/20
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Banco Santander Totta
Concluded
2011/01/01 - 2013/12/31 Interaction between endoplasmic reticulum stress-mediated endothelial dysfunction and hippocampal neurogenesis. Potential therapeutic target for the treatment of Alzheimer´s disease
PrémioPfizerSPN2010
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Pfizer Portugal
Concluded
2010/04/01 - 2013/03/31 Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis: new targets for brain repair therapies
PTDC/SAU-NEU/101783/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2011/12/31 Early Diagnosis of Alzheimer´s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10/01 - 2010/09/30 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease
PTDC/SAU-NEU/71675/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/11/01 - 2004/10/31 Role of exocytotic presynaptic proteins in synaptic apoptosis induced by amyloid-beta
--
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
Outputs

Publications

Conference abstract
  1. Ferreiro, Elisabete; Mariana Monteiro; Guida Bento; Francisco Pereira; Vilma Sardão; Paula Macedo; Paulo J Oliveira. "Exploratory data analysis applied to metabolic profiling of urine-derived stem cells from young and elderly women". Paper presented in ESCI Virtual Meeting 2020, 2020.
    Published
  2. Ferreiro, Elisabete; Costa, Rui O; Resende, Rosa; Pereira, Cláudia Fragão. "Communication between endoplamic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide.". Paper presented in 5th International Congress on Vascular Dementia, Budapest, 2009.
    Published • 10.1016/j.jns.2009.02.158
Conference poster
  1. Mena, Débora; Pedro Soares; Cagide, Fernando; Benfeito, Ester; Grilo, Luís F.; Daniela F. Silva; Valente, Pedro; et al. "The mitochondria-targeted antioxdiant AntiOxCIN4 is beneficial against oxidative/nitrosive stress in the amyotrophic lateral sclerosis SOD1G3A mouse". Paper presented in 56th Annual meeting of he European Society for Clinical Investigation, ¿Promoting Biomedical Research, Equal Health and Environment in the post-COVID Syndemic Era, 2022.
  2. Mena, Débora; Pedro Soares; Cagide, Fernando; Benfeito, Ester; Grilo, Luís F.; Daniela F. Silva; Valente, Pedro; et al. "The Mitochondria-Targeted Antioxidant Antioxcin4 Protects Against Oxidative/Nitrosative Stress in the Amyotrophic Lateral Sclerosis SOD1GG3A Mouse". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  3. Ferreiro, Elisabete; Lanzillo M; Mota, S.I.; Canhoto D; Silva A. M; Dias S.I; Ferreira, I.L.; et al. "Chronic hyperglycemia impairs hippocampal neurogenic reserve and memory in an alzheimer¿s disease mouse model". Paper presented in ADPD 2019, 2019.
  4. Ana Cristina Rego; Ferreiro, Elisabete; Inês Pita; Sandra Isabel Mota; Jorge Valero; Nuno Ferreira; Carlos Fontes-Ribeiro; et al. "Enhanced complexity of hippocampal dentate gyrus newly-generated neurons in mice following Coriolus versicolor biomass administration". Paper presented in FENS 2018, Berlin, Germany, 2018.
  5. Frederico Pereira; Ferreiro, Elisabete; Inês Pita; Sandra Isabel Mota; Jorge Valero; Nuno Ferreira; Carlos Fontes-Ribeiro; et al. "Coriolus Versicolor biomass increases hippocampal dentate gyrus newly-generated neurons complexity in mice". Paper presented in World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 2018.
  6. Ferreiro, Elisabete; Mariagrazia Lanzillo; Paulo Pinheiro; Diogo Canhoto; António Silva; Giorgia Mastrella; Ana Raquel Fontes; Jorge Valero; Ana Cristina Rego. "Chronic hyperglycemia impairs the maturation of newly-generated hippocampal neurons and exacerbates memory loss in a transgenic mouse model of Alzheimer’s disease". Paper presented in Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2017.
  7. Ferreiro, Elisabete; Mariagrazia Lanzillo; António Silva; Giorgia Mastrella; Ana Raquel Fontes; Jorge Valero; Ana Cristina Rego. "Chronic hyperglycemia impairs hippocampal newly-generated neurons maturation and exacerbates memory loss in a transgenic mouse model of Alzheimer’s disease". Paper presented in 10th Forum of European Neuroscience, Copenhagen, Denmark, 2016.
  8. Ferreiro, Elisabete; Mariagrazia Lanzillo; António Silva; Giorgia Mastrella; Ana Raquel Fontes; Jorge Valero; Ana Cristina Rego. "Hyperglycemia impairs dendritic arborization and synaptic puncta of hippocampal newly-generated neurons in Alzheimer’s disease". Paper presented in Synaptic Dysfunction and Dysfunction in Brain Disease, 7th ISN Special Neurochemistry Conference, Coimbra, Portugal, 2016.
  9. Ferreiro, Elisabete; Mariagrazia Lanzillo; António Silva; Giorgia Mastrella; Ana Raquel Fontes; Ildete Luísa Ferreira; Catarina Resende de Oliveira; Jorge Valero; Ana Cristina Rego. "Effect of chronic hyperglycemia on newly-generated neurons maturation and memory in a transgenic mouse model of Alzheimer’s disease". Paper presented in XIV Meeting of the Portuguese Society for Neuroscience, Póvoa do Varzim, Portugal, 2015.
  10. Ferreiro, Elisabete; Mariagrazia Lanzillo; António Silva; Giorgia Mastrella; Sandra Isabel Mota; Ana Raquel Fontes; Ildete Luísa Ferreira; et al. "Linking impairment of hippocampal neurogenesis and memory loss in a diabetic-like Alzheimer’s disease mouse model". Paper presented in Adult Neurogenesis: Evolution, Regulation and Function. Adult Neurogenesis: Evolution, Regulation and Function, Dresden, Germany, 2015.
  11. Ildete Luísa Ferreira; Ferreiro, Elisabete; Jeannette Schmidt; João Manuel Cardoso; Cláudia Maria Fragão Pereira; Ana Luísa Carvalho; Catarina Resende de Oliveira; Ana Cristina Rego. "Amyloid-beta peptide and N-methyl-D-aspartate receptor activation cause mitochondrial dysfunction involving calcium release from endoplasmic reticulum". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal, 2014.
    10.2991/amms-17.2017.47
  12. Ferreiro, Elisabete; Mariagrazia Lanzillo; António Silva; Giorgia Mastrella; Sandra Isabel Mota; Ana Raquel Fontes; Ildete Luísa Ferreira; et al. "Impaired memory in a transgenic mice model of Alzheimer’s disease under hyperglycemia – a link to reduced hippocampal neurogenesis?". Paper presented in XII CNC Annual meeting. University of Coimbra – pólo II, Coimbra, Portugal, 2014.
  13. Ildete Luísa Ferreira; Ferreiro, Elisabete; Jeannette Schmidt; João Manuel Cardoso; Cláudia Maria Fragão Pereira; Ana Luísa Carvalho; Catarina Resende de Oliveira; Ana Cristina Rego. "Synergistic effect of Aß and GluN2B-composed NMDA receptor activation on mitochondrial dysregulation involving ER calcium release". Paper presented in XII CNC Annual, Meeting. University of Coimbra – pólo II, Coimbra, Portugal, 2014.
  14. Sandra Isabel Mota; Ildete Luísa Ferreira; Jorge Valero; Ferreiro, Elisabete; Ana Luísa Carvalho; Catarina Resende de Oliveira; Ana Cristina Rego. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer´s disease mice hippocampus - linking NMDA receptors and the reelin pathway". Paper presented in XII CNC Annual Meeting. University of Coimbra – pólo II, Coimbra, Portugal, 2014.
  15. Ferreiro, Elisabete; Lanzillo M; Silva, A.M.; Mastrella, G.; Mota, S.I.; Fontes, A.R.; Ferreira, I.L.; et al. "Impaired memory in a transgenic mouse model of Alzheimer¿s disease under hyperglycemia ¿ a link to reduced hippocampal neurogenesis?". Paper presented in XII CNC Annual Meeting, 2014.
  16. Sandra Isabel Mota; Ildete Luísa Ferreira; Ferreiro, Elisabete; Ana Luísa Carvalho; Catarina Resende de Oliveira; Ana Cristina Rego. "NMDA receptor and Src related signaling in Alzheimer’s disease". Paper presented in 4th PF2MUC Symposium: Personalized Medicine: Myth or Reality? Faculty of Medicine, Health Science Campus, University of Coimbra, Portugal, 2013.
  17. Jorge Valero; Ismael Neiva; Giorgia Mastrella; Ferreiro, Elisabete; João Malva. "Long term effects of LPS administration on spatial memory and adult neurogenesis". Paper presented in 15º Congreso Nacional de la Sociedad Española de NeuroCiencia, Oviedo, Spain, 2013.
  18. Ildete Luísa Ferreira; Ferreiro, Elisabete; Sandra Isabel Mota; João Manuel Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Ana Cristina Rego. "In situ mitochondrial dysfunction evoked by immediate exposure to amyloid-beta 1-42 and NMDA receptor activation involving calcium release from endoplasmic reticulum". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience, Luso, Portugal, 2013.
  19. Sandra Isabel Mota; Ildete Luísa Ferreira; Ferreiro, Elisabete; Ana Luísa Carvalho; Catarina Resende de Oliveira; Ana Cristina Rego. "Altered NMDA receptor and Src related signaling in Alzheimer’s disease". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience, Luso, Portugal, 2013.
  20. Ildete Luísa Ferreira; Ferreiro, Elisabete; Sandra Isabel Mota; João Manuel Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Ana Cristina Rego. "Simultaneous exposure to amyloid-beta peptide and NMDA leads to mitochondrial calcium retention involving the release of calcium from the endoplasmic reticulum". Paper presented in Cell Symposia Mitochondria: from Signaling to Disease, Lisbon, Portugal, 2013.
  21. Sandra Isabel Mota; Rui O Costa; Gladys Caldeira; Lino Ferreira; Ferreiro, Elisabete; Isabel Santana; Carmela Padovano; et al. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer´s disease". Paper presented in Cold-Spring Harbour, New York, USA, 2012.
  22. Ferreiro, Elisabete; Ildete Luísa Ferreira; João Manuel Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Ana Cristina Rego. "Amyloid-beta 1-42 peptide-evoked changes in calcium levels and mitochondrial function through activation of NMDA receptors in rat cortical neurons". Paper presented in 8th Forum of European Neuroscience, Barcelona, Spain, 2012.
  23. Ferreiro, Elisabete; Ana Isabel Plácido; Catarina Resende de Oliveira; Moreira, Paula Isabel; Cláudia Maria Fragão Pereira. "Role of endoplasmic reticulum in the endothelial-neuronal dialogue in Alzheimer´s disease". Paper presented in 8th Forum of European Neuroscience, Barcelona, Spain, 2012.
  24. Sandra Isabel Mota; Ildete Luísa Ferreira; Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira; Ana Cristina Rego. "Age and gender-dependent changes in NMDA receptor subunit protein expression and activation in Alzheimer’s disease transgenic mice cortex and hippocampus". Paper presented in 8th Forum of European Neuroscience, Barcelona, Spain, 2012.
  25. Mota, S.I.; Ferreira, I.L.; Ferreiro, Elisabete; Pereira, Cláudia Maria Pereira; Oliveira, C.R.; Rego, Ana Cristina. "Age and gender-dependent modifications in NMDA receptor subunits in the cortex and hippocampus of Alzheimer¿s disease transgenic mice". Paper presented in 8th FENS Forum of Neuroscience, 2012.
  26. Ferreiro, Elisabete; Jorge Valero; Liliana Bernardino; Cláudia Maria Fragão Pereira; Fabienne Agasse. "Impaired properties of stem/progenitor cells contribute to decreased neurogenesis in the triple transgenic mouse model of Alzheimer’s disease". Paper presented in Annual meeting of the Society for Neuroscience, Washington D.C., EUA, 2011.
  27. Ana Isabel Plácido; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Moreira, Paula Isabel. "Endoplasmic reticulum stress induces brain endothelial cells dysfunction and death independently of caspase-12 pathway". Paper presented in 1st PF2MUC Symposium, Coimbra, Portugal, 2011.
  28. Ana Catarina Fonseca; Ferreiro, Elisabete; Sandra Morais Cardoso; Cláudia Maria Fragão Pereira. "Amyloid-beta induces endoplasmic reticulum stress in brain endothelial cells". Paper presented in 1st PF2MUC Symposium, Coimbra, Portugal, 2011.
  29. Ferreiro, Elisabete; Ildete Luísa Ferreira; João Manuel Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Ana Cristina Rego. "Mitochondria control NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons". Paper presented in AAICAD 2011: Alzheimer's Association International Conference on Alzheimer's Disease, Paris, France, 2011.
  30. Ana Isabel Plácido; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Conditioned medium from brain endothelial cells submitted to endoplasmic reticulum stress protects hippocampal and cortical neurons against amyloid-beta toxicity". Paper presented in Signal 2011, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, 2011.
  31. Ferreiro, Elisabete; Rui O Costa; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Paper presented in Fifth Forum of European Neuroscience, Amsterdam, The Netherlands, 2010.
  32. Cláudia Maria Fragão Pereira; Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sandra Morais Cardoso; Catarina Resende de Oliveira. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease–associated beta-amyloid peptide". Paper presented in ICAD 2008: Alzheimer's Association International Conference on Alzheimer's Disease, Chicago, Illinois, USA, 2008.
  33. Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sueli Marques; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Paper presented in Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007.
  34. Cláudia Maria Fragão Pereira; Ana Catarina Fonseca; Rosa Resende; Ferreiro, Elisabete; Catarina Resende de Oliveira. "Statins prevent beta-amyloid-induced toxicity in cortical neurons". Paper presented in Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007.
  35. Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "A via apoptótica é activada pelo cálcio libertado do retículo endoplasmático após exposição aos peptídeos da beta-amilóide e do prião". Paper presented in 21ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Curia, Portugal, 2007.
  36. Rui O Costa; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to alzheimer´s disease". Paper presented in 10th Meeting Portuguese Society for Neuroscience, Ofir, Portugal, 2007.
  37. Rosa Resende; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Endoplasmic reticulum stress induced by Aß1-42 oligomers leads to GSK3ß-mediated tau phosphorylation". Paper presented in 10th Meeting Portuguese Society for Neuroscience, Ofir, Portugal, 2007.
  38. Ferreiro, Elisabete; Rui O Costa; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on alzheimer’s disease cybrids". Paper presented in 8th International Conference on Alzheimer`s and Parkinson`s Diseases (AD/PD 2007), Salzburg, Austria, 2007.
  39. Ferreiro, Elisabete; Rui O Costa; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Paper presented in 15th National Congress of Biochemistry, Aveiro, Portugal, 2006.
  40. A. Gouveia; Ferreiro, Elisabete; Rui O Costa; Catarina Resende de Oliveira. "Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer". Paper presented in V Congresso de Investigação em Medicina, Coimbra, Portugal, 2006.
  41. Ferreiro, Elisabete; Rui O Costa; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Paper presented in V Congresso de Investigação em Medicina, Coimbra, Portugal, 2006.
  42. Ferreiro, Elisabete; Rui O Costa; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Paper presented in The 10th International conference on Alzheimer´s disease and related disorders, Madrid, Spain, 2006.
  43. Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Endoplasmic reticulum dysfunction and oxidative stress induced by the prion peptide". Paper presented in 20th Biennial Meeting of the International Society for Neurochemistry jointly with the European Society for Neurochemistry, Innsbruck, Austria, 2005.
  44. Rosa Resende; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "The role of endoplasmic reticulum in amyloid-beta-induced synaptotoxicity". Paper presented in 34th annual meeting of the Society for Neuroscience, San Diego, USA, 2004.
  45. Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Role of ryanodine and 1,4,5-inositol triphosphate receptors in the neurotoxic effect of amyloid-beta (Aß) and prion (PrP) peptides". Paper presented in New molecular strategies to treat neurodegenerative diseases – Advanced course of FEBS, Ofir, Portugal, 2004.
  46. Ferreiro, Elisabete; Rosa Resende; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Endoplasmic reticulum-mediated apoptosis induced by Abeta peptide". Paper presented in The 5th International Cell Death Symposium On "The Mechanisms of Cell Death", Maynooth, Ireland, 2004.
  47. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Endoplasmic reticulum dysfunction induced by the Prion peptide". Paper presented in 33rd annual metting of the Society for Neuroscience, New Orleans, USA, 2003.
  48. Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Ca2+ release from endoplasmic reticulum induced by Abeta and PrP peptides leads to oxidative stress in cortical neurons". Paper presented in 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 1st Luso-Spanish Congress on Free Radicals, Coimbra, Portugal, 2003.
  49. Rosa Resende; Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Levels of synaptic protein markers under apoptotic-like conditions”. 11th Euroconference on Apoptosis". Paper presented in Cell death under the three towers", Ghent, Belgium, 2003.
  50. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Endoplasmic reticulum-mediated apoptosis induced by Abeta and PrP peptides". Paper presented in 11th Euroconference on Apoptosis "Cell death under the three towers", Ghent, Belgium, 2003.
  51. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Envolvimento da libertação de Ca2+ do retículo endoplasmático no efeito neurotóxico induzido pelo peptídeo da beta-amilóide". Paper presented in 17ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Curia, Portugal, 2003.
  52. Rosa Resende; Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Cortical neuron apoptosis induced by tumor necrosis factor alfa (TNF-alfa), staurosporine, thapsigargin and beta-amyloid peptide 1-40 (Abeta1-40)". Paper presented in 8th Meeting of the Portuguese Society for Neurosciences, Curia, Portugal, 2003.
  53. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Role of the endoplasmic reticulum in the neurotoxic effect induced by the prion peptide". Paper presented in 8th Meeting of the Portuguese Society for Neurosciences, Curia, Portugal, 2003.
  54. Cláudia Maria Fragão Pereira; Ferreiro, Elisabete; Catarina Resende de Oliveira. "Cross-talk between the endoplasmic reticulum and mitochondria during Abeta- and PrP-induced apoptotic neuronal death". Paper presented in XIII Congresso Nacional de Bioquímica, Lisbon, Portugal, 2002.
  55. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Stresse do retículo endoplasmático induzido pelos peptídeos sintéticos do prião (PrP106-126) e da beta-amilóide (Abeta25-35)". Paper presented in III Congresso de Investigação em Medicina, Coimbra, Portugal, 2002.
  56. Ferreiro, Elisabete; Cláudia Maria Fragão Pereira; Catarina Resende de Oliveira. "Envolvimento do retículo endoplasmático na morte neuronal induzida pelos peptídeos sintéticos do prião (PrP106-126) e da beta-amilóide (Abeta25-35)". Paper presented in 16ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, Tomar, Portugal, 2002.
  57. Ana Eufrásio; Ferreiro, Elisabete; Ana Cristina Rego; Cláudia Maria Fragão Pereira; Paula Agostinho; Catarina Resende de Oliveira. "Efeito da expressão de Bcl-2 na toxicidade induzida pelo prião e pela proteína beta-amilóide em células hipotalâmicas GT1-7". Paper presented in ”. I Workshop de Investigação em Medicina, Faculty of Medicine of the University of Coimbra, Portugal, 2001.
Journal article
  1. Ferreiro, Elisabete; Monteiro, Mariana; Pereira, Francisco; Barroso, Cristina; Egas, Conceição; Macedo, Paula; Valero, Jorge; Sardão, Vilma A.; Oliveira, Paulo J.. Corresponding author: Oliveira, Paulo J.. "Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells". Mechanisms of Ageing and Development 218 (2024): 111912. http://dx.doi.org/10.1016/j.mad.2024.111912.
    10.1016/j.mad.2024.111912
  2. Teresa Cunha-Oliveira; Liliana Montezinho; Rui F. Simões; Marcelo Carvalho; Elisabete Ferreiro; Filomena S. G. Silva. "Mitochondria: A Promising Convergent Target for the Treatment of Amyotrophic Lateral Sclerosis". Cells (2024): https://doi.org/10.3390/cells13030248.
    10.3390/cells13030248
  3. Gonçalo J. M. Afonso; Carla Cavaleiro; Jorge Valero; Sandra I. Mota; Elisabete Ferreiro. "Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives". Cells (2023): https://doi.org/10.3390/cells12131763.
    10.3390/cells12131763
  4. Cavaleiro, C.; Afonso, G.J.M.; Oliveira, P.J.; Valero, J.; Mota, S.I.; Ferreiro, E.. "Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions". Frontiers in Molecular Neuroscience 16 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85176442233&partnerID=MN8TOARS.
    10.3389/fnmol.2023.1229728
  5. Elisabete Ferreiro; Tito Fernandes. "Targeting Neurogenesis with Mushroom Nutrition: A Mini Review". Clinical Journal of Mycology Vol VI Edition 1. 6 1 (2022): https://doi.org/10.54225/cjm.vol6.2.35294.
    10.54225/cjm.vol6.2.35294
  6. Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites. "Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice". Cells (2022): https://doi.org/10.3390/cells11010137.
    10.3390/cells11010137
  7. Cunha-Oliveira, T.; Carvalho, M.; Sardão, V.; Ferreiro, E.; Mena, D.; Pereira, F.B.; Borges, F.; et al. "Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints". Molecular Neurobiology 59 10 (2022): 6373-6396. http://www.scopus.com/inward/record.url?eid=2-s2.0-85135617163&partnerID=MN8TOARS.
    Submitted • 10.1007/s12035-022-02980-7
  8. Filipa F. Ribeiro; Filipa Ferreira; Rui S. Rodrigues; Rita Soares; Diogo M. Pedro; Marta Duarte-Samartinho; Rita I. Aroeira; et al. "Regulation of hippocampal postnatal and adult neurogenesis by adenosine A 2A receptor: Interaction with brain-derived neurotrophic factor". STEM CELLS 39 10 (2021): 1362-1381. https://doi.org/10.1002/stem.3421.
    10.1002/stem.3421
  9. Carvalhais, Lia G.; Martinho, Vera C.; Ferreiro, Elisabete; Pinheiro, Paulo S.. "Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy". Frontiers in Neuroscience 14 (2021): http://dx.doi.org/10.3389/fnins.2020.578409.
    Open access • 10.3389/fnins.2020.578409
  10. Ferreiro, Elisabete; Mariagrazia Lanzillo; Diogo Canhoto; António Silva; Sandra Isabel Mota; Inês Dias; Ildete Luísa Ferreira; et al. "Chronic Hyperglycemia Impairs Hippocampal Neurogenesis and Memory in an Alzheimer’s disease mouse model". Neurobiology of Aging (2020): http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003.
    10.1016/j.neurobiolaging.2020.04.003
  11. Barros-Viegas, A.T.; Carmona, V.; Ferreiro, E.; Guedes, J.; Cardoso, A.M.; Cunha, P.; Pereira de Almeida, L.; et al. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079208982&partnerID=MN8TOARS.
    10.1016/j.omtn.2020.01.010
  12. Saraiva, C.; Barata-Antunes, S.; Santos, T.; Ferreiro, E.; Cristóvão, A.C.; Serra-Almeida, C.; Ferreira, R.; Bernardino, L.. "Histamine modulates hippocampal inflammation and neurogenesis in adult mice". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067204850&partnerID=MN8TOARS.
    10.1038/s41598-019-44816-w
  13. Dioli, C.; Patrício, P.; Sousa, N.; Kokras, N.; Dalla, C.; Guerreiro, S.; Santos-Silva, M.A.; et al. "Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields". Translational Psychiatry 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064910305&partnerID=MN8TOARS.
    10.1038/s41398-019-0477-7
  14. Silva, A.C.; Ferreira, I.L.; Hayden, M.R.; Ferreiro, E.; Rego, A.C.. "Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1864 1 (2018): 34-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031746642&partnerID=MN8TOARS.
    10.1016/j.bbadis.2017.09.009
  15. Ferreiro, E.; Pita, I.R.; Mota, S.I.; Valero, J.; Ferreira, N.R.; Fernandes, T.; Calabrese, V.; et al. "Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus". Oncotarget 9 68 (2018): 32929-32942. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052580513&partnerID=MN8TOARS.
    10.18632/oncotarget.25978
  16. Dioli, C.; Patrício, P.; Trindade, R.; Pinto, L.G.; Silva, J.M.; Morais, M.; Ferreiro, E.; et al. "Tau-dependent suppression of adult neurogenesis in the stressed hippocampus". Molecular Psychiatry 22 8 (2017): 1110-1118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026899195&partnerID=MN8TOARS.
    10.1038/mp.2017.103
  17. Naia, L.; Ferreira, I.L.; Ferreiro, E.; Rego, A.C.. "Mitochondrial Ca2+handling in Huntington's and Alzheimer's diseases – Role of ER-mitochondria crosstalk". Biochemical and Biophysical Research Communications 483 4 (2017): 1069-1077. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998772500&partnerID=MN8TOARS.
    10.1016/j.bbrc.2016.07.122
  18. Robledinos-Antón, N.; Rojo, A.I.; Ferreiro, E.; Núñez, Á.; Krause, K.-H.; Jaquet, V.; Cuadrado, A.. "Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus". Redox Biology 13 (2017): 393-401. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021413702&partnerID=MN8TOARS.
    10.1016/j.redox.2017.06.010
  19. Figueira, I.; Fernandes, A.; Mladenovic Djordjevic, A.; Lopez-Contreras, A.; Henriques, C.M.; Selman, C.; Ferreiro, E.; et al. "Interventions for age-related diseases: Shifting the paradigm". Mechanisms of Ageing and Development 160 (2016): 69-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999035290&partnerID=MN8TOARS.
    10.1016/j.mad.2016.09.009
  20. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  21. Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation". Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.06.012
  22. Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2014.09.006
  23. Monteiro-Cardoso, V.F.; Oliveira, M.M.; Melo, T.; Domingues, M.R.M.; Moreira, P.I.; Ferreiro, E.; Peixoto, F.; Videira, R.A.. "Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer's disease". Journal of Alzheimer's Disease 43 4 (2014): 1375-1392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919926803&partnerID=MN8TOARS.
    10.3233/JAD-141002
  24. Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS.
    10.1016/j.expneurol.2014.07.023
  25. Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F.. "Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 12 (2013): 2191-2203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.08.007
  26. Resende, R.; Marques, S.C.F.; Ferreiro, E.; Simões, I.; Oliveira, C.R.; Pereira, C.M.F.. "Effect of a-Synuclein on amyloid ß-Induced toxicity: Relevance to lewy body variant of alzheimer disease". Neurochemical Research 38 4 (2013): 797-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164250&partnerID=MN8TOARS.
    10.1007/s11064-013-0982-7
  27. Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS.
    10.1016/j.mcn.2012.09.005
  28. Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F.. "Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice". Neuroscience 220 (2012): 256-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864770859&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2012.06.029
  29. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS.
    10.1155/2012/735206
  30. Ferreiro, E.; Pereira, C.M.F.. "Endoplasmic reticulum stress: A new playER in tauopathies". Journal of Pathology 226 5 (2012): 687-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857998807&partnerID=MN8TOARS.
    10.1002/path.3977
  31. Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.04.011
  32. Ferreira, I.L.; Resende, R.; Ferreiro, E.; Rego, A.C.; Pereira, C.F.. "Multiple defects in energy metabolism in Alzheimer's disease". Current Drug Targets 11 10 (2010): 1193-1206. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957994659&partnerID=MN8TOARS.
  33. Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS.
    10.3233/JAD-2010-091369
  34. Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway". Neurobiology of Disease 30 3 (2008): 331-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-43649083316&partnerID=MN8TOARS.
    10.1016/j.nbd.2008.02.003
  35. Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05048.x
  36. Resende, R.; Ferreiro, E.; Pereira, C.; Resende de Oliveira, C.. "Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death". Neuroscience 155 3 (2008): 725-737. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249118742&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2008.06.036
  37. Resende, R.; Ferreiro, E.; Pereira, C.; Oliveira, C.R.. "ER stress is involved in Aß-induced GSK-3ß activation and tau phosphorylation". Journal of Neuroscience Research 86 9 (2008): 2091-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249157930&partnerID=MN8TOARS.
    10.1002/jnr.21648
  38. Ferreiro, Elisabete; Rui O Costa; Sueli Marques; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Role of endoplasmic reticulum-mediated apoptotic pathway in Ab toxicity". Cognitive Sciences at the Leading Edge 2 (2007): 1-26.
    Published
  39. Ferreiro, E.; Eufrásio, A.; Pereira, C.; Oliveira, C.R.; Rego, A.C.. "Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells". Journal of Alzheimer's Disease 12 3 (2007): 223-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549064191&partnerID=MN8TOARS.
  40. Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.; Costa, Rui Miguel Oliveira da; Ferreiro, Elisabete; Resende de Oliveira, Catarina; Pereira, Cláudia. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". Journal of Neurochemistry 102 Supplement (2007): 68-69. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248991600162&KeyUID=WOS:000248991600162.
    Published
  41. Ferreiro, Elisabete; Resende, Rosa; Costa, Rui Miguel Oliveira da; Moreira, Paula Isabel; Morais Cardoso, Sandra; Pereira, Cláudia; Resende de Oliveira, Catarina; et al. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Free Radical Research 41 (2007): S11-S11. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300021&KeyUID=WOS:000252296300021.
  42. Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.05.011
  43. Ferreiro, Elisabete; Resende, Rosa; Resende de Oliveira, Catarina; Pereira, Cláudia. "Mechanism of amyloid-beta induced early synaptotoxicity.". Sinapse 5 1 (2005): 101-101.
    Published
  44. Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-ß peptide". Journal of Neuroscience Research 76 6 (2004): 872-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642541799&partnerID=MN8TOARS.
    10.1002/jnr.20135
  45. Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R.. "Cell degeneration induced by amyloid-ß peptides: Implications for Alzheimer's disease". Journal of Molecular Neuroscience 23 1-2 (2004): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669435&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Ferreiro, Elisabete. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides: implications for the etiopathogenesis of Alzheimer's disease and prion disorders". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2008.

Other

Other output
  1. Age-Dependent Energy Metabolism and Transcriptome Changes in Urine-Derived Stem Cells. 2023. Ferreiro, E.; Monteiro, M.; Pereira, F.; Barroso, C.; Egas, C.; Macedo, M.P.; Valero, J.; Sardão, V.A.; Oliveira, P.J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85171419863&partnerID=MN8TOARS.
    10.2139/ssrn.4563589
  2. A new method and tool for volumetric estimation of brain structures after serial sectioning. 2022. Ferreiro, E.; Rodríguez-Iglesias, N.; Cardoso, J.; Valero, J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128821754&partnerID=MN8TOARS.
    10.1101/2022.03.18.484850
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/12/15 Can Mushroom Nutrition Increase Neurogenic Reserve? Implications for Neurodegenerative Conditions.
Mycology Research Laboratories
2020/09 Exploratory data analysis applied to metabolic profiling of urine-derived stem cells from young and elderly women Annual Meeting of the European Society for Clinical Investigation, Virtual Meeting,
2019/11/07 Coriolus versicolor puede aumentar la reserva neurogénica? Implicaciones para las condiciones generadoras de neuronas 10º Congresso de Fitoterapia de SEFIT
Faculty of Medicine University of Santiago de la Compostela Santiago de la Compostela (Santiago de la Compostela, Spain)
2019/09/27 Can Mushroom Nutrition Increase Neurogenic Reserve? Implications for Neurodegenerative Conditions Meeting of the Associazione Medici Italiani Anti Aging
Associazione Medici Italiani Anti Aging (Pádua, Italy)
2018/02/05 Coriolus Versicolor Biomass Increases Dendritic Arborization Of Newly-generated Neurons In Mouse Hippocampal Dentate Gyrus Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
2017/02/02 Comorbid effect of chronic hyperglycemia and alzheimer’s disease on hippocampal adult neurogenesis Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2016/11/14 Metabolic and cognitive alterations in an Alzheimer´s disease mouse model under chronic hyperglycemia Developing interventions for frailty: what do we measure?, Meeting of the COST Action BM1402
COST Action BM1402 (Viena)
2016/04/11 Hyperglycemia exacerbates memory loss and impairs maturation of hippocampal newly generated neurons in a transgenic mouse model of Alzheimer’s disease Reaching consensus on reverse translation for frailty and multimorbidity. Meeting of the COST Action BM1402
COST Action BM1402 (Madrid, Spain)
2014/11/14 Adult Neurogenesis in the 3xTg-AD mouse model of Alzheimer´s disease Seminar
Achucarro Basque Center (Bilbao, Spain)
2014/06/27 Linking NMDA receptors and the reelin pathway in Alzheimer’s disease mice model 28ª Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências
Grupo de Estudo de Envelhecimento Cerebral e Demências (Aveiro, Portugal)
2014/06/27 Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release 28ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Aveiro, Portugal)
2013/10/24 Neurogenesis and Alzheimer's disease: characterization of stem and progenitor properties in a transgenic mouse model IBRO Symposium "Current Aspects in Pathophysiology of Alzheimer´s disease: what do we miss?"
icvs (Braga, Portugal)
2013/05/30 Imbalance in the stem/progenitor cells properties leads to the suppression of neurogenesis in the triple transgenic mouse model of Alzheimer’s disease XIII Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Luso, Portugal)
2013/05/30 Altered NMDA receptor and Src related signaling in Alzheimer’s disease XIII Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Luso, Portugal)
2011/06/03 Amyloid-beta peptide induces endoplasmic reticulum stress-mediated cell death in brain endothelial cells 25ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2011/06/03 Impaired properties of stem/progenitor cells contribute to decreased neurogenesis in the triple transgenic mouse model of Alzheimer’s disease 25ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2011/06/03 Amyloid ß1-42 oligomers induce cytosolic Ca2+ increase and mitochondrial depolarization through NR2B-containing NMDARs in cortical neurons 25ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar)
2011/05/26 Amyloid-ß oligomers drive early excitotoxic events in Alzheimer’s disease XII Meeting of the Portuguese Society for Neuroscience,
Portuguese Society for Neuroscience (Lisboa, Portugal)
2010/06/25 Role of endothelial cells on survival of mature neurons. Implications for the etiopathogenesis of Alzheimer´s disease , 24ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06/06 O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na Doença de Alzheimer 22ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2007/06/08 Interacção entre as proteínas ß-amyloid e a-sinucleína na doença de Alzheimer 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2007/06/08 Aß1-42 oligomers induce endoplasmic reticulum stress and GSK3ß-mediated tau phosphorylation 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2007/06/08 Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer 21ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2006/12/05 Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides XXXVII Reunião Annual da Sociedade Portiguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portiguesa de Farmacologia e Reunião de Farmacologia Clínica (Porto, Portugal)
2006/06/24 , Role of mitochondria in ER-mediated apoptosis induced by the amyloid-beta peptide 20ª Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2005/05/19 Mechanism of amyloid-beta induced early synaptotoxicity Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Luso)
2004/12/02 Role of beta-amyloid peptides on Alzheimer´s disease neuronal degeneration XIV Congresso Nacional de Bioquímica
Portuguese Society of Biochemistry (Vilamoura, Portugal)
2003/06/13 Comunicação entre o retículo endoplasmático e a mitocôndria. Relevância para a doença de Alzheimer 17ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Curia, Portugal)
2002/09/12 Cell degeneration induced by amyloid-beta peptides: Implications for Alzheimer´s disease Novel Therapeutic Opportunities in Neurodegenerative Disease
(Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01/01 - 2026/09/01 Potential of human neurons transdifferentiated from urine-derived stem cells for ALS precision medicine
Supervisor of Carla Sofia Teixeira Cavaleiro
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/01 - 2025/04/30 Metabolic profiling and reversion of mitochondrial dysfunction in Amyotrophic lateral sclerosis patients: innovative application of human neuronal cells differentiated from urine-derived stem cells.
Supervisor of Gonçalo José Martins Afonso
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/02/15 - 2022/07/15 Optimization of a cryopreservation protocol for urine-derived stem cells from ALS patients
Supervisor of Diogo Pato
 Engenharia Biomédica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/02/15 - 2022/07/15 Optimization of a isolation protocol for urine-derived stem cells from ALS patients
Supervisor of Daniel Costa
 Engenharia Biomédica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/10/01 - 2016/11/25 Involvement of beta-catenin in the maturation of newly-generated hippocampal neurons in an Alzheimer´s disease mouse model subjected to hyperglycemia
Co-supervisor
 Mestrado em Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/11/01 - 2014/10/30 Hyperglycemia and Alzheimer’s Disease Influence on Neurogenesis
Co-supervisor
2013/09/01 - 2014/07/31 Involvement of vascular dysfunction in the neurogenesis impairment that occurs in Alzheimer’s disease
Supervisor
 Mestrado em Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/04/01 - 2014/03/31 Characterization of neurogenesis in a transgenic model of Alzheimer’s disease
Co-supervisor
 International Master Degree of Neuroscience (Master)
Università degli Studi di Trieste, Italy

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2013/05/30 - 2013/06/01 Organization of the Meeting “13ª Reunião da Sociedade Portuguesa de Neurociências" (2013/05/30 - 2013/06/01)
Conference (Member of the Organising Committee)
 Sociedade Portuguesa de Neurociências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2008/03/12 - Current Brain Awareness Week
Other
 Visit to school
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/09/23 A novel RNA-targeted therapeutic approach for Alzheimer's disease and Down syndrome
(Thesis) Main arguer
 Carlos Manuel Campos Marques (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/07/30 Intracerebrovascular injection of amyloid ß1-42 peptide in rat behavior and adult hippocampal neurogenesis
(Thesis) Main arguer
 Sara Raquel Landeira Nabais do Paulo (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/03/27 Tau (mal)function in brain plasticity and pathology: a gateway beyond Alzheimer´s disease
(Thesis) Arguer
 Joana Margarida Gonçalves Mota Silva (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016/11/08 The role of AP2¿ transcription factor in the modulation of adult glutamatergic neurogenesis in depression
(Thesis) Main arguer
 Eduardo Manuel Loureiro de Campos (Master)
Universidade do Minho Escola de Medicina, Portugal
2014/11/05 Subregion-dependent specificities of the hippocampal formation to the acute application of Aß oligomers
(Thesis) Main arguer
 João Pedro Rodrigues Pizarro (Master)
Universidade do Minho Escola de Medicina, Portugal
2013/12/12 Identifying the mechanistic role of Tau protein in brain´s risk and protective factors
(Thesis) Main arguer
 Ana Rita Vieira Trindade da Silva (Master)
Universidade do Minho Escola de Medicina, Portugal
Distinctions

Award

2020 Best oral presentation award
2011 Best researcher poster award
2010 Prémio Envelhecimento e Demência Cerebral, Doença de Alzheimer 2010
Pfizer Portugal, Portugal

Sociedade Portuguesa de Neurociências, Portugal