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Dr. Luís M. P. Lima holds a Degree in Technological Chemistry from the University of Lisbon (FCUL, 2001), and a PhD in Inorganic Chemistry from the NOVA University of Lisbon (ITQB, 2009) working under the supervision of Prof. Rita Delgado. After completing his PhD, he was a Postdoctoral Research Assistant at the Université de Bretagne Occidentale (Brest, France) from 2010 to 2011 and then at ITQB NOVA from 2011 to 2018. Since 2018, Dr. Lima has been a Research Associate at the ITQB NOVA within the group of Dr. Royo, working in several projects exploring the coordination of transition metal cations to polyamine ligands for potential applications in Medicine and Biology. Dr. Lima is co-author of 39 papers in international peer-reviewed journals (3 as corresponding author), 1 book chapter, 2 international patents (1 pending), 10 oral communications, and 28 posters. He has received almost 1200 citations with an h-index of 20. He was a visiting PhD student at the Charles University in Prague (CZ, 6 months), and a visiting Researcher at the Western Sydney University (AUS, 1 month). Over the last five years (2018 to date), Dr. Lima has co-authored 11 papers published in international peer-reviewed journals, 2 of them as corresponding author, receiving over 600 citations with an h-index of 15. He was also the co-author of a filed international patent request, pending approval. He was the co-author of 3 oral communications and 1 poster. During this period, he was Supervisor of 2 Master students and has tutored 4 visiting students (2 undergraduate, 1 Master, and 1 PhD). In 2021, Dr. Lima was co-recipient of the Early Career Researcher Award from ITQB NOVA. He holds several national and international collaborations, including with chemists Raphaël Tripier (UBO, France, since 2011) and Feng Li (WSU, Australia, since 2017), and also with microbiologist Catarina Pimentel (ITQB NOVA, since 2019). Despite being a full-time Researcher, Dr. Lima has recently been involved in teaching activities both at ITQB NOVA (Lab course, Integrated Laboratory Practices II, Master degree in Biochemistry for Health, 2020 to date) and at the Faculty of Sciences of the University of Lisbon (Invited Lecturer, Chemical systems and Reactivity, Master degree in Chemistry, 2020 and 2021). Dr. Lima has participated in several funded research projects, and is currently the Principal Investigator of an ongoing FCT-funded exploratory project targeting "Azole metal complexes as a promising source for new antifungals" (2022.04565.PTDC).
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Identification

Personal identification

Full name
Luís Miguel Barroso Pereira Lima

Citation names

  • Lima, Luís M. P.

Author identifiers

Ciência ID
031A-1146-2A2A
ORCID iD
0000-0002-9729-330X
Researcher Id
B-3757-2011
Scopus Author Id
35080690600

Email addresses

  • llima@itqb.unl.pt (Professional)

Telephones

Telephone
  • 214469755 (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2009
Concluded
 Inorganic Chemistry (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Development of new tetraaza macrocyclic chelators for transition and lanthanide metal ions" (THESIS/DISSERTATION)
 Unanimously approved
2001
Concluded
 Technological Chemistry (Licenciatura)
Major in Química Tecnológica
Universidade de Lisboa Faculdade de Ciências, Portugal
"Influência dos constituintes no comportamento de tinta alquídica para madeira" (THESIS/DISSERTATION)
 15 out of 20
Affiliation

Science

Category
Host institution 		Employer
2018/07/01 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/02/01 - 2019/03/08 Visiting Researcher (Research) Western Sydney University School of Science and Health, Australia
Western Sydney University - Parramatta Campus, Australia
2011/09/01 - 2018/06/30 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/05 - 2011/06 Postdoc (Research) Université de Bretagne Occidentale, France
Université de Bretagne Occidentale, France
(...)
2009/12/18 - 2010/04/30 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Others

Category
Host institution 		Employer
2004/10/01 - 2009/12/17 PhD Student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2002/05/01 - 2004/09/30 Graduate Research Student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2000/11/01 - 2001/10/01 Undergraduate Trainee Laboratório Nacional de Engenharia Civil, Portugal
Projects

Grant

Designation Funders
2013/07/01 - 2016/06/30 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
info:eu-repo/grantAgreement/FCT/3599-PPCDT/127013/PT
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2015/11/30 Development of dinuclear Cu(II) and Zn(II) complexes as potential inhibitors of oncogenic protein-protein interactions
info:eu-repo/grantAgreement/FCT/3599-PPCDT/128644/PT
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/06/01 - 2010/04/30 Development of new macrocyclic bifunctional chelators for metalloradiopharmaceuticals
PTDC/QUI/67175/2006
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/05/01 - 2004/09/30 Radiopharmaceuticals for treatment of bone cancer pain and/or therapy based on macrocyclic lanthanide complexes.
info:eu-repo/grantAgreement/FCT/POCI/35859/PT
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/09/01 - Current Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

BioResources 4 Sustainability, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Azole metal complexes as a promising source for new antifungals
2022.04565.PTDC
10.54499/2022.04565.PTDC
Principal investigator
Universidade NOVA de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Molecular, Structural and Cellular Microbiology
UID/CBQ/04612/2019
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/07/01 - 2016/06/30 NMR Net - Centro Nacional de Ressonância Magnética Nuclear: desde a Estrutura e Dinâmica Moleculares à Função Proteica, Fisiologia Celular e Metabolómica
RECI/BBB-BQB/0230/2012
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Lima, Luís M.P.; Iranzo, O.. "Engineering Short Preorganized Peptide Sequences for Metal Ion Coordination". In Peptide, Protein and Enzyme Design, 333-364. Elsevier, 2016.
    10.1016/bs.mie.2016.04.007
Conference poster
  1. Catarina Amaral; Sofia M. da Silva; W. Antunes; G. Duarte, Américo; E. Moe; Lima, Luís M. P.; N. A. Faria; et al. "From lab to field: low cost saliva tests for mass-screening of SARS-CoV-2". Paper presented in V International Conference NOVAhealth Chronic Disease and Infection, 2022.
  2. Catarina Amaral. "A LAMP-based test to detect SARS-CoV-2 in saliva samples". Paper presented in IUBMB-FEBS-PABMB 2022 Congress, 2022.
  3. Cláudia M. Luís; Pissarro, Teresa; Ana Carolina Gaspar-Cordeiro; Lima, Luís M. P.; Catarina Pimentel. "Combining copper and azoles: towards more effective antifungal agents". Paper presented in FEBS 2022, 2022.
  4. Pedras, Andreia; Luís, Cláudia; Gaspar-Cordeiro, A.; G. Duarte, Américo; Antunes, Wilson; Lima, Luís M. P.; Amaral, Catarina; Pimentel, Catarina. "Effect of iron on the antifungal activity of caspofungin". Paper presented in TIMB3 Final Meeting, 2022.
  5. Ana Carolina Gaspar-Cordeiro; Catarina Amaral; Pissarro, Teresa; Cláudia M. Luís; Vânia Pobre; Wilson Antunes; Lima, Luís M. P.; et al. "Copper potentiates fluconazole activity against Candida glabrata". Paper presented in ASM Microbe, 2022.
  6. Ana Carolina Gaspar-Cordeiro; Pissarro, Teresa; Sofia da Silva; Mário Aguiar; Claudina Rodrigues-Pousada; Hubertus Haas; Lima, Luís M. P.; Catarina Pimentel. "Copper(II)-binding triazole derivatives: promising bifunctional antifungals". Paper presented in Candida and Candidiasis, Online event, 2021.
  7. Lima, Luís M. P.. "Development and modus operandi of a copper binding antifungal drug". Paper presented in 4th FesBioNet COST Action Meeting, 2019.
  8. Lima, Luís M. P.. "Cyclen-based macrocycles for the complexation of Bi3+ for alpha-radioimmunotherapy". Paper presented in 42nd International Conference on Coordination Chemistry (ICCC2016), 2016.
  9. Lima, Luís M. P.. "Cyclen-based macrocycles for the complexation of Bi3+ for alpha-radioimmunotherapy". Paper presented in 10th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC2015), 2015.
  10. Lima, Luís M. P.. "Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands". Paper presented in International Symposium on Metal Complexes 2015 (ISMEC2014), 2015.
  11. Lima, Luís M. P.. "Copper(II) Complexes of Phenanthroline Amino Acid Derivatives: Synthesis, Characterization and Evaluation of their DNA Cleavage and Cytotoxic Activity". Paper presented in 2014 annual meeting of the French BioInorganic Chemistry group (FrenchBIC), 2014.
  12. Lima, Luís M. P.. "Cyclen-based ligands with pendant picolinate arms: attractive chelators for a-radioimmunotherapy applications". Paper presented in Dalton Discussion 15 - Metal ions in medical imaging: optical, radiopharmaceutical and MRI contrast, 2014.
  13. Lima, Luís M. P.. "Kinetic comparative study of copper(II) complexes with DOTA and TETA analogs". Paper presented in Dalton Discussion 15 - Metal ions in medical imaging: optical, radiopharmaceutical and MRI contrast, 2014.
  14. Lima, Luís M. P.. "New cyclam derivatives containing 2-hydroxybenzyl pendant arms: Complexation studies with copper(II) and other cations". Paper presented in 5th EuCheMS Chemistry Congress, 2014.
  15. Lima, Luís M. P.. "Tacn-dithiazole: synthèse et complexation du Cu(II) pour une application en médecine nucléaire". Paper presented in 5èmes reencontres du Groupe d'étude em chimie des Polyamines cycliques et linéaires (GPOL 2014), 2014.
  16. Lima, Luís M. P.. "Cyclen and cross-bridged cyclen derivatives trans-N-disubstituted for copper(II) complexation". Paper presented in 4th EuCheMS Chemistry Congress, 2012.
  17. Lima, Luís M. P.. "Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation". Paper presented in 4ème rencontres du Groupe d'études en chimie des polyamines cycliques et linéaires (GPOL 2012), 2012.
  18. Lima, Luís M. P.. "Positively Charged Lanthanide Complexes with Cyclen-Based Ligands: Synthesis, Solid State and Solution Structure, and Fluoride Recognition". Paper presented in 4ème rencontres du Groupe d'études en chimie des polyamines cycliques et linéaires (GPOL 2012), 2012.
  19. Lima, Luís M. P.. "Cross-bridged cyclen derivative: synthesis, acid-base and metal complexation studies". Paper presented in International Symposium on Metal Complexes 2012 (ISMEC2012), 2012.
  20. Lima, Luís M. P.. "Cross-bridged cyclen derivatives: synthesis, acid-base and metal complexation studies". Paper presented in XXII Encontro Nacional da SPQ, 2011.
  21. Lima, Luís M. P.. "Development of a new cyclen derivative for the complexation of copper(II) and lanthanide(III) ions as a potential BFC for medical applications". Paper presented in 3rd EuCheMS Chemistry Congress, 2010.
  22. Lima, Luís M. P.. "Synthesis, thermodynamic stability and structural studies of new cyclen derivatives with coordinating pendant arms". Paper presented in 3rd EuCheMS Chemistry Congress, 2010.
  23. Lima, Luís M. P.. "New tris(methylphosphonate)hydroxypropyl cyclen derivative for the complexation of copper(II) and lanthanide(III) ions as a potentially versatile bifunctional chelator". Paper presented in 2nd Portuguese Young Chemists Meeting, 2010.
  24. Lima, Luís M. P.. "New cyclen derivatives with pendant arms for possible medical applications". Paper presented in 2nd Portuguese Young Chemists Meeting, 2010.
  25. Lima, Luís M. P.. "Reinvestigation of solution behaviour of gallium(III)/H3nota and gallium(III)/H4dota systems". Paper presented in 2008 Annual Meeting of the COST Action D38, 2008.
  26. Lima, Luís M. P.. "New DOTP analogue for possible medical applications". Paper presented in II International Symposium on Macrocyclic and Supramolecular Chemistry, 2007.
  27. Lima, Luís M. P.. "Metal complexes of a new tetraaza macrocyclic ligand bearing carboxylate and phosphonate pendant arms". Paper presented in 1st EuCheMS Chemistry Congress, 2006.
  28. Lima, Luís M. P.. "13- to 14- membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation". Paper presented in 2005 Annual Workshop of the COST Action D18, 2005.
  29. Lima, Luís M. P.. "Metal complexes of a tetraazamacrocycle with mixed pendant arms". Paper presented in XXX International Symposium on Macrocyclic Chemistry, 2005.
  30. Lima, Luís M. P.. "Lanthanide complexes of tetraazamacrocycles useful for medical applications". Paper presented in 6th Conference on Inorganic Chemistry of the Portuguese Chemistry Society, 2005.
  31. Lima, Luís M. P.. "Radiochemical and Biological Behavior of Tetraazamacrocycles with Different Pendant Arms". Paper presented in 2004 Annual Workshop of the COST Action D18, 2004.
  32. Lima, Luís M. P.. "Lanthanide complexes of 14-membered tetraazamacrocycles with three acetate pendant arms: The influence of an addicional arm". Paper presented in XXIX International Symposium on Macrocyclic Chemistry, 2004.
  33. Lima, Luís M. P.. "Lanthanide complexes of a new cyclam derivative containing methylcarboxylate and methylphosphonate pendant arms". Paper presented in 28th International Symposium on Macrocyclic Chemistry, 2003.
  34. Lima, Luís M. P.; Delgado, Rita. "Metal complexes of new N-tetrasubstituted tetraazamacrocycles including methylcarboxylate pendant arms". Paper presented in 7th FIGIPS Meeting in Inorganic Chemistry, 2003.
Journal article
  1. Julie Pineau; Luís M. P. Lima; Marie M. Le Roy; Séverine Marionneau-Lambot; Marie Cordier; Patricia Le Saëc; Jan Rijn Zeevaart; et al. "Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution". Chemical Communications (2023): https://doi.org/10.1039/D2CC06602E.
    10.1039/D2CC06602E
  2. Pineau, Julie; Lima, Luís M. P.; Platas-Iglesias, Carlos; Zeevaart, Jan Rijn; Driver, Cathryn H. S.; Le Bris, Nathalie; Tripier, Raphaël. "Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA". Chemistry – A European Journal 28 41 (2022): http://dx.doi.org/10.1002/chem.202200942.
    10.1002/chem.202200942
  3. "Palladium(II) coordination with polyazacycloalkanes". Coordination Chemistry Reviews 455 (2022): 214343-214343. http://dx.doi.org/10.1016/j.ccr.2021.214343.
    10.1016/j.ccr.2021.214343
  4. "A molecular test based on RT-LAMP for rapid, sensitive and inexpensive colorimetric detection of SARS-CoV-2 in clinical samples". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-95799-6.
    10.1038/s41598-021-95799-6
  5. "Correction to: A copper(II)-binding triazole derivative with ionophore properties is active against Candida spp.". JBIC Journal of Biological Inorganic Chemistry 26 4 (2021): 533-534. http://dx.doi.org/10.1007/s00775-021-01871-x.
    10.1007/s00775-021-01871-x
  6. Filipe M. Sousa; Luís M. P. Lima; Clément Arnarez; Manuela M. Pereira; Manuel N. Melo. "Coarse-Grained Parameterization of Nucleotide Cofactors and Metabolites: Protonation Constants, Partition Coefficients, and Model Topologies". Journal of Chemical Information and Modeling 61 1 (2021): 335-346. https://doi.org/10.1021/acs.jcim.0c01077.
    10.1021/acs.jcim.0c01077
  7. "A copper(II)-binding triazole derivative with ionophore properties is active against Candida spp.". JBIC Journal of Biological Inorganic Chemistry 25 8 (2020): 1117-1128. http://dx.doi.org/10.1007/s00775-020-01828-6.
    10.1007/s00775-020-01828-6
  8. Fanna, Daniel J.; Lima, Luís M.P.; Wei, Gang; Li, Feng; Reynolds, Jason K.. "A colorimetric chemosensor for quantification of exchangeable Cu2+ in soil". Chemosphere 238 (2020): 124664. http://dx.doi.org/10.1016/j.chemosphere.2019.124664.
    10.1016/j.chemosphere.2019.124664
  9. Guillou, Amaury; Lima, Luís M. P.; Esteban-Gómez, David; Le Poul, Nicolas; Bartholomä, Mark D.; Platas-Iglesias, Carlos; Delgado, Rita; Patinec, Véronique; Tripier, Raphaël. "Methylthiazolyl Tacn Ligands for Copper Complexation and Their Bifunctional Chelating Agent Derivatives for Bioconjugation and Copper-64 Radiolabeling: An Example with Bombesin". Inorganic Chemistry 58 4 (2019): 2669-2685. http://dx.doi.org/10.1021/acs.inorgchem.8b03280.
    10.1021/acs.inorgchem.8b03280
  10. Amaury Guillou; Luís M. P. Lima; David Esteban-Gómez; Rita Delgado; Carlos Platas-Iglesias; Véronique Patinec; Raphaël Tripier. "endo- versus exo-Cyclic coordination in copper complexes with methylthiazolylcarboxylate tacn derivatives". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01366K.
    10.1039/C9DT01366K
  11. Fanna, Daniel J.; Lima, Luís M. P.; Craze, Alexander R.; Trinchi, Adrian; Wei, Gang; Reynolds, Jason K.; Li, Feng. "Determination of Cu2+ in drinking water using a hydroxyjulolidine-dihydroperimidine colorimetric sensor". Journal of Inclusion Phenomena and Macrocyclic Chemistry 94 3-4 (2018): 141-154. http://dx.doi.org/10.1007/s10847-018-0862-5.
    10.1007/s10847-018-0862-5
  12. Fanna, Daniel J.; Lima, Luís M. P.; Craze, Alexander R.; Trinchi, Adrian; Wuhrer, Richard; Lindoy, Leonard F.; Wei, Gang; Reynolds, Jason K.; Li, Feng. "Ultrasensitive Colorimetric and Ratiometric Detection of Cu2+: Acid–Base Properties, Complexation, and Binding Studies". ACS Omega 3 9 (2018): 10471-10480. http://dx.doi.org/10.1021/acsomega.8b01483.
    10.1021/acsomega.8b01483
  13. Chakraborty, Sourav; Saha, Subrata; Lima, Luís M. P.; Warzok, Ulrike; Sarkar, Sayan; Akhuli, Bidyut; Nandi, Mandira; et al. "Polyamide–Polyamine Cryptand as Dicarboxylate Receptor: Dianion Binding Studies in the Solid State, in Solution, and in the Gas Phase". The Journal of Organic Chemistry 82 19 (2017): 10007-10014. http://dx.doi.org/10.1021/acs.joc.7b01431.
    10.1021/acs.joc.7b01431
  14. Guillou, Amaury; Lima, Luís M. P.; Roger, Mélissa; Esteban-Gómez, David; Delgado, Rita; Platas-Iglesias, Carlos; Patinec, Véronique; Tripier, Raphaël. "1,4,7-Triazacyclononane-Based Bifunctional Picolinate Ligands for Efficient Copper Complexation". European Journal of Inorganic Chemistry 2017 18 (2017): 2435-2443. http://dx.doi.org/10.1002/ejic.201700176.
    10.1002/ejic.201700176
  15. Leite, Sílvia M. G.; Lima, Luís M. P.; Gama, Sofia; Mendes, Filipa; Orio, Maylis; Bento, Isabel; Paulo, António; Delgado, Rita; Iranzo, Olga. "Copper(II) Complexes of Phenanthroline and Histidine Containing Ligands: Synthesis, Characterization and Evaluation of their DNA Cleavage and Cytotoxic Activity". Inorganic Chemistry 55 22 (2016): 11801-11814. http://dx.doi.org/10.1021/acs.inorgchem.6b01884.
    10.1021/acs.inorgchem.6b01884
  16. Le Fur, Mariane; Beyler, Maryline; Le Poul, Nicolas; Lima, Luís M. P.; Le Mest, Yves; Delgado, Rita; Platas-Iglesias, Carlos; Patinec, Véronique; Tripier, Raphaël. "Improving the stability and inertness of Cu(II) and Cu(I) complexes with methylthiazolyl ligands by tuning the macrocyclic structure". Dalton Transactions 45 17 (2016): 7406-7420. http://dx.doi.org/10.1039/c6dt00385k.
    10.1039/c6dt00385k
  17. Rodríguez-Rodríguez, Aurora; Halime, Zakaria; Lima, Luís M. P.; Beyler, Maryline; Deniaud, David; Le Poul, Nicolas; Delgado, Rita; et al. "Cyclams with Ambidentate Methylthiazolyl Pendants for Stable, Inert, and Selective Cu(II) Coordination". Inorganic Chemistry 55 2 (2015): 619-632. http://dx.doi.org/10.1021/acs.inorgchem.5b01779.
    10.1021/acs.inorgchem.5b01779
  18. Lima, Luís M. P.; Beyler, Maryline; Delgado, Rita; Platas-Iglesias, Carlos; Tripier, Raphaël. "Investigating the Complexation of the Pb2+/Bi3+ Pair with Dipicolinate Cyclen Ligands". Inorganic Chemistry 54 14 (2015): 7045-7057. http://dx.doi.org/10.1021/acs.inorgchem.5b01079.
    10.1021/acs.inorgchem.5b01079
  19. Rodríguez-Rodríguez, Aurora; Garda, Zoltán; Ruscsák, Erika; Esteban-Gómez, David; de Blas, Andrés; Rodríguez-Blas, Teresa; Lima, Luís M. P.; et al. "Stable Mn2+, Cu2+ and Ln3+ complexes with cyclen-based ligands functionalized with picolinate pendant arms". Dalton Transactions 44 11 (2015): 5017-5031. http://dx.doi.org/10.1039/c4dt02985b.
    10.1039/c4dt02985b
  20. Regueiro-Figueroa, Martín; Lima, Luís M. P.; Blanco, Víctor; Esteban-Gómez, David; de Blas, Andrés; Rodríguez-Blas, Teresa; Delgado, Rita; Platas-Iglesias, Carlos. "Reasons behind the Relative Abundances of Heptacoordinate Complexes along the Late First-Row Transition Metal Series". Inorganic Chemistry 53 24 (2014): 12859-12869. http://dx.doi.org/10.1021/ic501869y.
    10.1021/ic501869y
  21. Lima, Luís M. P.; Halime, Zakaria; Marion, Ronan; Camus, Nathalie; Delgado, Rita; Platas-Iglesias, Carlos; Tripier, Raphaël. "Monopicolinate Cross-Bridged Cyclam Combining Very Fast Complexation with Very High Stability and Inertness of Its Copper(II) Complex". Inorganic Chemistry 53 10 (2014): 5269-5279. http://dx.doi.org/10.1021/ic500491c.
    10.1021/ic500491c
  22. Esteves, Catarina V.; Madureira, Joana; Lima, Luís M. P.; Mateus, Pedro; Bento, Isabel; Delgado, Rita. "Copper(II) and Gallium(III) Complexes of trans-Bis(2-hydroxybenzyl) Cyclen Derivatives: Absence of a Cross-Bridge Proves Surprisingly More Favorable". Inorganic Chemistry 53 9 (2014): 4371-4386. http://dx.doi.org/10.1021/ic403156h.
    10.1021/ic403156h
  23. Lima, Luís M. P.; Beyler, Maryline; Oukhatar, Fatima; Le Saec, Patricia; Faivre-Chauvet, Alain; Platas-Iglesias, Carlos; Delgado, Rita; Tripier, Raphaël. "H2Me-do2pa: an attractive chelator with fast, stable and inert natBi3+ and 213Bi3+ complexation for potential a-radioimmunotherapy applications". Chem. Commun. 50 82 (2014): 12371-12374. http://dx.doi.org/10.1039/c4cc05529b.
    10.1039/c4cc05529b
  24. Roger, Melissa; Lima, Luís M. P.; Frindel, Mathieu; Platas-Iglesias, Carlos; Gestin, Jean-François; Delgado, Rita; Patinec, Véronique; Tripier, Raphaël. "Monopicolinate-dipicolyl Derivative of Triazacyclononane for Stable Complexation of Cu2+ and 64Cu2+". Inorganic Chemistry 52 9 (2013): 5246-5259. http://dx.doi.org/10.1021/ic400174r.
    10.1021/ic400174r
  25. Mateus, Pedro; Lima, Luís M.P.; Delgado, Rita. "Di- and trinuclear copper(II) complexes of polyaza macrocycles and cryptands as anion receptors". Polyhedron 52 (2013): 25-42. http://dx.doi.org/10.1016/j.poly.2012.07.073.
    10.1016/j.poly.2012.07.073
  26. Esteves, Catarina V.; Lima, Luís M. P.; Mateus, Pedro; Delgado, Rita; Brandão, Paula; Félix, Vítor. "Cyclen derivatives with two trans-methylnitrophenolic pendant arms: a structural study of their copper(ii) and zinc(ii) complexes". Dalton Transactions 42 17 (2013): 6149-6160. http://dx.doi.org/10.1039/c2dt32363j.
    10.1039/c2dt32363j
  27. Corcé, Vincent; Morin, Emmanuelle; Guihéneuf, Solène; Renault, Eric; Renaud, Stéphanie; Cannie, Isabelle; Tripier, Raphaël; et al. "Polyaminoquinoline Iron Chelators for Vectorization of Antiproliferative Agents: Design, Synthesis, and Validation". Bioconjugate Chemistry 23 9 (2012): 1952-1968. http://dx.doi.org/10.1021/bc300324c.
    10.1021/bc300324c
  28. Lima, Luís M. P.; Esteban-Gómez, David; Delgado, Rita; Platas-Iglesias, Carlos; Tripier, Raphaël. "Monopicolinate Cyclen and Cyclam Derivatives for Stable Copper(II) Complexation". Inorganic Chemistry 51 12 (2012): 6916-6927. http://dx.doi.org/10.1021/ic300784v.
    10.1021/ic300784v
  29. Lima, Luís M. P.; Delgado, Rita; Hermann, Petr; Ševcík, Radek; Lubal, Premysl; Carvalho, Henrique F.; Martins, André F.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln3+ Complexes". European Journal of Inorganic Chemistry 2012 15 (2012): 2548-2559. http://dx.doi.org/10.1002/ejic.201101335.
    10.1002/ejic.201101335
  30. Lima, Luís M. P.; Esteves, Catarina V.; Delgado, Rita; Hermann, Petr; Kotek, Jan; Ševcíková, Romana; Lubal, Premysl. "Tris(phosphonomethyl) Cyclen Derivatives: Synthesis, Acid-Base Properties and Complexation Studies with Cu2+ and Zn2+ Ions". European Journal of Inorganic Chemistry 2012 15 (2012): 2533-2547. http://dx.doi.org/10.1002/ejic.201101334.
    10.1002/ejic.201101334
  31. Lima, Luís M. P.; Lecointre, Alexandre; Morfin, Jean-François; de Blas, Andrés; Visvikis, Dimitris; Charbonnière, Loïc J.; Platas-Iglesias, Carlos; Tripier, Raphaël. "Positively Charged Lanthanide Complexes with Cyclen-Based Ligands: Synthesis, Solid-State and Solution Structure, and Fluoride Interaction". Inorganic Chemistry 50 24 (2011): 12508-12521. http://dx.doi.org/10.1021/ic201447c.
    10.1021/ic201447c
  32. Lima, Luís M. P.; Tripier, Raphael. "Cyclen-Based Lanthanide Complexes as Luminescent Anion Receptors". Current Inorganic Chemistry 1 1 (2011): 36-60. http://dx.doi.org/10.2174/1877944111101010036.
    10.2174/1877944111101010036
  33. Lima, Luís M. P.; Delgado, Rita; Plutnar, Jan; Hermann, Petr; Kotek, Jan. "A New Tris(phosphonomethyl) Monoacetic Acid Cyclam Derivative: Synthesis, Acid-Base and Metal Complexation Studies". European Journal of Inorganic Chemistry 2011 4 (2010): 527-538. http://dx.doi.org/10.1002/ejic.201000919.
    10.1002/ejic.201000919
  34. Lima, Luís M.P.; Delgado, Rita; Marques, Fernanda; Gano, Lurdes; Santos, Isabel. "TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes". European Journal of Medicinal Chemistry 45 12 (2010): 5621-5627. http://dx.doi.org/10.1016/j.ejmech.2010.09.013.
    10.1016/j.ejmech.2010.09.013
  35. Lima, Luís M. P.; Delgado, Rita; Drew, Michael G. B.; Brandão, Paula; Félix, Vítor. "Cyclam derivatives containing three acetate pendant arms: synthesis, acid–base, metal complexation and structural studies". Dalton Transactions 46 (2008): 6593-6608. http://dx.doi.org/10.1039/b809100e.
    10.1039/b809100e
  36. Delgado, Rita; Félix, Vítor; Lima, Luís M. P.; Price, David W.. "Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data". Dalton Trans. 26 (2007): 2734-2745. http://dx.doi.org/10.1039/b704360k.
    10.1039/b704360k
  37. Marques, Fernanda; Gano, Lurdes; Paula Campello, M.; Lacerda, Sara; Santos, Isabel; Lima, Luís M.P.; Costa, Judite; Antunes, Patrícia; Delgado, Rita. "13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation". Journal of Inorganic Biochemistry 100 2 (2006): 270-280. http://dx.doi.org/10.1016/j.jinorgbio.2005.11.011.
    10.1016/j.jinorgbio.2005.11.011
  38. Delgado, Rita; Costa, Judite; Guerra, Krassimira P.; Lima, Luís M. P.. "Lanthanide complexes of macrocyclic derivatives useful for medical applications". Pure and Applied Chemistry 77 3 (2005): 569-579. http://dx.doi.org/10.1351/pac200577030569.
    10.1351/pac200577030569
  39. Marques, Fernanda; Guerra, Krassimira P.; Gano, Lurdes; Costa, Judite; Campello, M. Paula; Lima, Luís M. P.; Delgado, Rita; Santos, Isabel. "153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms". JBIC Journal of Biological Inorganic Chemistry 9 7 (2004): 859-872. http://dx.doi.org/10.1007/s00775-004-0587-3.
    10.1007/s00775-004-0587-3
  40. Guerra, Krassimira P.; Delgado, Rita; Lima, Luís M. P.; Drew, Michael G. B.; Félix, Vítor. "Bis- and tris-(methylphosphonic) acid derivatives of a 14-membered tetraazamacrocycle containing pyridine: synthesis, protonation and complexation studies". Dalton Trans. 12 (2004): 1812-1822. http://dx.doi.org/10.1039/b403977g.
    10.1039/b403977g
Thesis / Dissertation
  1. Lima, Luís M. P.. "New tetraaza macrocyclic ligands with potential medical interest - Synthesis and study of their transition metal and lanthanide complexes". PhD, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2009.
  2. Lima, Luís M. P.. "Influência dos constituintes no comportamento de tinta alquídica para madeira". Degree, Universidade de Lisboa Faculdade de Ciências, 2001.

Intellectual property

Patent
  1. Tripier, Raphaël; Platas-Iglesias, Carlos; Lima, Luís M. P.; Beyler, Maryline. 2014. "Chelates of lead(II) and bismuth(III) based on trans-di-N-picolinate tetraazacycloalkanes". France.
    Granted/Issued
Provisional application for patent
  1. 2021. "COLORIMERIC METHOD FOR DETECTION OF AMPLIFIED GENETIC MATERIAL AND USES THEREOF".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/01/30 Ultrasensitive colorimetric copper(II) chemosensors for environmental applications III International Workshop on Chemistry of Group 11 Elements
(Caparica, Portugal)
2018/09/04 New bombesin conjugated bifunctional 64Cu tacn-based chelates for PET application 7th EuCheMS Conference on Nitrogen Ligands
(Lisboa, Portugal)
2017/07/11 Copper complexation with tacn based bifunctional picolinate ligands for potential PET application International Symposium on Metal Complexes 2017 (ISMEC2017)
(Dijon, France)
2015/06/24 Contribution of Thiazolyle Arms in the Stability of Cu(II)/Cu(I) Polyazacycloalcane-based Chelates for PET Imaging International Symposium on Metal Complexes 2015 (ISMEC2015)
(Wroclav, Poland)
2014/06/23 Synthèse et étude de complexes de Bismuth(III) et de Plomb(II) pour l’alpha-radioimmunothérapie 5èmes reencontres du Groupe d'étude em chimie des Polyamines cycliques et linéaires (GPOL 2014)
(Klingenthal, France)
2014/06/23 1,4-dipicolyl-tacn : une plateforme pour la synthèse de nouveaux chélates pour l’imagerie 5èmes reencontres du Groupe d'étude em chimie des Polyamines cycliques et linéaires (GPOL 2014)
(Klingenthal, France)
2014/06/08 Kinetic study of copper(II) complexes of TETA-like macrocyclic ligands International Symposium on Metal Complexes 2014 (ISMEC2014)
(Pavia, Italy)
2012/06/18 Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation International Symposium on Metal Complexes 2012 (ISMEC2012)
(Lisboa, Portugal)
2006/07/01 Metal complexes of macrocyclic derivatives for medical applications 8th European Biological Inorganic Chemistry Conference
(Aveiro, Portugal)
2004/07/25 Lanthanide complexes of macrocyclic derivatives useful for medical applications: a critical evaluation of stability constants 11th International Symposium on Solubility Phenomena
(Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/09/01 - 2021/08/31 Exploring novel copper(II) binding azole compounds as potential antifungal drugs
Supervisor of Teresa Pissarro
 Bichemistry for Health (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/09/01 - 2021/08/31 Developing fluorescent antifungal azole compounds for live fungal cell imaging
Supervisor of Luana Ferreira
 Biochemistry for Health (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/07/19 - 2019/10/26 ITQB Open Day 2019 (2019/10/26)
Exhibition (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/03/01 - 2017/07/28 2017 Summer Science @ ITQB NOVA (2017/07/24 - 2017/07/28)
Other (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006/01/01 - 2006/01/28 ITQB Open Day 2006 (2006/01/28)
Exhibition (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/09/17 - 2019/09/17 ITQB International Microorganism Day 2019
Exhibition
 ITQB International Microorganism Day 2019
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/05/27 - 2017/05/27 ITQB Open Day 2017
Exhibition
 ITQB Open Day 2017
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/10/10 - 2015/10/10 ITQB Open Day 2015
Exhibition
 ITQB Open Day 2015
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/04/20 - 2013/04/20 ITQB Open Day 2013
Exhibition
 ITQB Open Day 2013
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/02/27 - 2010/02/27 ITQB Open Day 2010
Exhibition
 ITQB Open Day 2010
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/02/23 - 2008/02/23 ITQB Open Day 2008
Exhibition
 ITQB Open Day 2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/01/29 - 2005/01/29 ITQB Open Day 2005
Exhibition
 ITQB Open Day 2005
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2016/07/01 Captura e Ativação de Dióxido de Carbono por Estruturas Metalo-Orgânicas
(Thesis) Main arguer
 Janaína Almeida (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/01/30 - 2023/02/03 Integrated Laboratory Practices II Biochemistry for Health Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/04/01 - 2022/04/01 Chemical Biology Curricular Unit, invited lecture on "Metal complexes as powerful tools in biology and medicine" Molecular Biosciences PhD program Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/02/21 - 2022/02/25 Integrated Laboratory Practices II Biochemistry for Health (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/03/15 - 2021/03/15 Chemical Systems and Reactivity Invited Lecture on Host-guest chemistry - cation binding, as introduction to the topic of supramolecular chemistry. Chemistry (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/02/22 - 2021/03/04 Integrated Laboratory Practices II Biochemistry for Health (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/03/23 - 2020/03/23 Chemical Systems and Reactivity; Invited Lecture on Host-guest chemistry - cation binding, as introduction to the topic of supramolecular chemistry. Chemistry (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/02/03 - 2020/02/14 Integrated Laboratory Practices II Biochemistry for Health (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Mentoring / Tutoring

Topic Student name
2021/10/01 - 2022/06/30 Development of novel cinnamyl-containing polyamine ligands for complexation of metals as potential antifungal drugs. Voluntary internship of a first-year Master student in Bioorganic Chemistry from FCT-UNL. Beatriz Garcia
2020/03/02 - 2020/06/01 Development of novel metal-binding azole compounds as potential antifungal drugs. Stylianos Pardalis
2019/07/03 - 2019/08/02 Development of novel azole compounds as potential antifungal drugs. Océane Rondot
2017/03/20 - 2017/04/12 Study of new colorimetric chemosensors for the detection of copper(II). Daniel J. Fanna
2016/07/08 - 2016/08/08 Development of copper(II) complexes with potential applications in nuclear medicine. Hanane Alatou
2016/07/04 - 2016/08/05 Synthesis and study of copper(II) complexes of homopiperazine derivatives. Patrícia Nunes
2015/07/19 - 2015/07/24 ANEM Science Summerschool 2015. Daniel Cipriano
2013/06/02 - 2013/07/30 Study of the copper(II) complexes of picolinate derivatives of 1,4,7-Triazacyclononane. Mélissa Roger
2013/07/01 - 2013/07/27 Study of the bismuth(III) complexation by dipicolinate cyclen derivatives. Maryline Beyler
2011/02/05 - 2011/06/17 Nouveaux chélates du bismuth et du plomb 212 pour l’apha-radioimmunothérapie. Zineb Liraki
Distinctions

Award

2021 Early Career Researcher Award 2021
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Other distinction

2010 Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2004 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal