Rui Miguel Gil da Costa (0318-98C4-ADCF)

Curriculum Vitae

Rui Miguel Gil da Costa

Rui M. Gil da Costa graduated as a veterinary surgeon in 2003 from the University of Trás-os-Montes and Alto Douro, Portugal. After practicing as an official veterinary surgeon in the United Kingdom, he took a MSc degree in Oncology, a Residency in Veterinary Pathology and a PhD in Biomedical Sciences at the University of Porto's Abel Salazar Institute for Biomedical Sciences. He first undertook post-doctoral studies at the University of Porto Faculty of Engineering and the Portuguese Institute of Oncology and then at Dr. Peter Nelson's lab (Fred Hutchinson Cancer Research Center, Seattle, USA). He is now an Assistant Professor at the Federal University of Maranhão (São Luís, Brazil) and remains a collaborating member of three Portuguese research groups: CITAB, CI-IPOP and LEPABE. He currently supervises/co-supervises one PhD student and 2 MSc students. He supervised/co-supervised one post-doctoral researcher, 2 PhD students, 20 MSc students and 3 BSc students. His work, largely focused on translational cancer research, originated over 100 indexed scientific papers (Scopus) with h index = 26, and is presently centred on genitourinary malignancies and tumours induced by human papillomavirus.

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Identification

Personal identification

Full name: Rui Miguel Gil da Costa

Citation names

Gil da Costa, R. M.

Author identifiers

Ciência ID: 0318-98C4-ADCF
ORCID iD: 0000-0002-2151-2449

Knowledge fields

Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening
English	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Intermediate (B1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Italian	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2012 Concluded	Doutoramento em Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Studies on the biopathological effects of Pteridium aquilinum" (THESIS/DISSERTATION)	Aprovado com distinção
2009 Concluded	European Course on the Pathology of Laboratory Animals (Curso médio) Institut Pasteur, France
2005 - 2008 Concluded	Residency in Veterinary Pathology (Outros) Universidade do Porto, Portugal
2008 Concluded	Science in Laboratory Animals - level C training (FELASA) (Curso médio) Universidade do Porto, Portugal
2008 Concluded	ECVP/ESVP Summer School in Veterinary Pathology (Curso médio) Universidad de Zaragoza, Spain
2007 Concluded	ECVP/ESVP Summer School in Veterinary Pathology (Curso médio) Helsingin yliopisto, Finland
2007 Concluded	Mestrado em Oncologia (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Canine cutaneous mast cell tumour: biopathological studies." (THESIS/DISSERTATION)	Muito Bom
2006 Concluded	ECVP/ESVP Summer School in Veterinary Pathology (Curso médio) Helsingin yliopisto, Finland
2005 Concluded	ECVP/ESVP Summer School in Veterinary Pathology (Curso médio) Università degli Studi di Padova, Italy
1997 - 2003 Concluded	Medicina Veterinária (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal "Isolamento e mapeamento físico de uma sequência de DNA satélite - CAFCA I - de Felis catus. Aplicações futuras na área clínica ao nível do diagnóstico. " (THESIS/DISSERTATION)	15
2003 Concluded	Official Veterinary Surgeon Training Course (Curso médio) University of Glasgow, United Kingdom
2003 Concluded	Licenciatura em Medicina Veterinária (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal "Isolation and physical mapping of a satellite DNA sequence - CAFCA I - from Felis catus." (THESIS/DISSERTATION)	15

Affiliation

Teaching in Higher Education

	Category Host institution	Employer
2023/11 - Current	Assistant Professor (University Teacher)	Universidade Federal do Maranhão, Brazil

2019/03/01 - 2023/03	Invited Full Professor (University Teacher)	Universidade Federal do Maranhão, Brazil

2012/09 - 2013/01	Assistant Professor (University Teacher)	Universidade do Porto, Portugal

2012/09 - 2013/01	Assistant Professor (University Teacher)	Universidade Lusófona, Portugal

2012/01 - 2012/06	Invited Assistant Professor (University Teacher)	Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Others

	Category Host institution	Employer
2011/09 - 2012/02	Outra Situação (Docente Universitário)	Universidade do Porto, Portugal

2007/03 - 2008/07	Outra Situação (Docente Universitário)	Universidade do Porto, Portugal

2005/02 - 2006/07	Outra Situação (Docente Universitário)	Universidade de Trás-os-Montes e Alto Douro, Portugal

Projects

Grant

	Designation	Funders
2013/06/01 - 2018/05/31	PAPILOMAVÍRUS E PTERIDIUM AQUILINUM: ESTUDO DA SUA INTERACÇÃO NO PROCESSO DE CARCINOGÉNESE SFRH/BPD/85462/2012	Fundação para a Ciência e a Tecnologia Concluded
2008/02/01 - 2012/01/31	ESTUDOS DE CARCINOGÉNESE POR PTERIDIUM AQUILINUM SFRH/BD/37565/2007	Fundação para a Ciência e a Tecnologia Concluded
2006/01/01 - 2006/12/31	ESTUDO DA EXPRESSÃO DO C-KIT, DO ÍNDICE PROLIFERATIVO KI-67 E DA ANGIOGÉNESE EM MASTOCITOMAS CUTÂNEOS DOS CANÍDEOS SFRH/BM/21610/2005	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2020 - 2024	Consolidação de doze programas de pós-graduação da UFMA nas áreas estratégicas de saúde, energia e biodiversidade com o foco no desenvolvimento socioeconômico e ambiental da amazônia legal./Consolidação de programas de pós-graduação como ferramenta para reduçao de distorções regionais no enfrentamen PDPG Amazônia Legal Researcher	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Ongoing
2021/03/10 - 2023/03/10	Envolvimento do HPV na doença arterial coronariana em mulheres climatéricas: atenção à saúde no Maranhão PPSUS-02160/20 Principal investigator Universidade Federal do Maranhão, Brazil	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão Conselho Nacional de Desenvolvimento Científico e Tecnológico Ongoing
2019 - 2023	Immune checkpoints como novos alvos para o tratamento do câncer de pênis FAPEMA 01337/19 Researcher	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão Concluded
2018/06/01 - 2022/02/28	Eficácia pré-clínica do sulforafano ou do extrato total de Brássicas: uma estratégia para combater a obesidade e valorizar os subprodutos de Brássicas PTDC/ASP-HOR/29152/2017 Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2022	Desenvolvimento de novas estratégias de prevenção e tratamento no estudo do câncer FAPEMA 30/2018 - IECT Researcher	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão Concluded
2018 - 2021	Influência do tabagismo e da infecção por HPV no desenvolvimento do câncer de pênis: estudos pré-clínicos e clínicos UNIVERSAL-01285/17 Researcher	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão
2017 - 2020	Why is Skeletal Muscle Tumor Suppressive? WM Keck Foundation 221856 Researcher Fred Hutchinson Cancer Center, United States	W M Keck Foundation Concluded
2019/01/01 - 2019/12/31	Centro de Investigação do Instituto Português de Oncologia do Porto UID/DTP/00776/2019 Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia UID/EQU/00511/2019 Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centro de Investigação e de Tecnologias Agro-Ambientais e Biológicas UID/AGR/04033/2019 Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2019	: Clinical Development of Therapeutic Strategies Targeting Damage Responses in the Prostate Tumor Microenvironment NIH/NCI P50 CA097186-15 Researcher Fred Hutchinson Cancer Center, United States	National Institutes of Health Concluded
2018 - 2019	Eradicating Metastatic Prostate Cancer through the Identification of Synergistic Drug Combinations DOD/PCPR W81XWH-18-1-0347 Researcher Fred Hutchinson Cancer Center, United States	US Department of Defence Defense Media Activity
2018 - 2019	Determining and Exploiting Mechanisms of AR-Mediated Suppression of Cell Proliferation and Survival NIH/NCI R01 CA266863-01 Researcher Fred Hutchinson Cancer Center, United States	Foundation for the National Institutes of Health
2011/01/01 - 2012/12/31	Projecto Estratégico - UI 511 - 2011-2012 PEst-C/EQB/UI0511/2011 Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Oliveira, P.A.; Vasconcelos-Nóbrega, C.; Gil da Costa, R.M.; Arantes-Rodrigues, R.. The N-butyl-N-4-hydroxybutyl nitrosamine mouse urinary bladder cancer model. 2018. 10.1007/978-1-4939-7234-0_13 Rui M. Gil da Costa; António Ramos Silva; Ana Faustino Rocha; Paula Alexandra Oliveira; Joaquim Gabriel; da Costa, R.M.G.; Oliveira, P.A.; et al. Thermography in animal models of cancer: a tool for studying oncobiology in laboratory animals. 2017. 10.4018/978-1-5225-2072-6.ch011 Gil da Costa, R.M.; Lopes, C.; Oliveira, P.A.; Bastos, M.M.S.M.; Gil da Costa, R. M.; Lopes, C; Oliveira, PA; Margarida M. S. M. Bastos. Illudane-type sesquiterpenes: Challenges and opportunities for toxicology and chemotherapy. 2014. Cortez, P.P.; Shirosaki, Y.; Botelho, C.M.; Simões, M.J.; Gartner, F.; Da Costa, R.M.G.; Tsuru, K.; et al. Hybrid chitosan membranes tested in sheep for guided tissue regeneration. 2008.
Book review	Cochicho, Daniela; Gil da Costa, Rui; Felix, Ana. "Exploring the roles of HPV16 variants in head and neck squamous cell carcinoma". http://hdl.handle.net/10362/127903. https://doi.org/10.1186/s12985-021-01688-9
Conference abstract	Medeiros, Catarina; Silva, Ana Rita; T. Ferreira; Barros, Lillian; Ferreira, Isabel C.F.R.; Gil da Costa, R. M. ; Gama, Adelina; Oliveira P.. "Morphometric measurements in HPV-transgenic mice after topical application of Cytinus hypocistis (L.) extract". Paper presented in II Symposium in Applied Biochemistry, Braga, 2021. Published Medeiros, Catarina; Silva, Ana Rita; T. Ferreira; Barros, Lillian; Ferreira, Isabel C.F.R.; Pires, Maria João; Gil da Costa, R. M. ; Gama, Adelina; Oliveira P.. "Effects of cytinus hypocistis (l.) L. extract in HPVtransgenic mice". Paper presented in International Conference on Medicinal and Food Plant Research & 3rd Sino-CPLP Symposium on Natural Products and Biodiversity Resources, Hanzhong, 2021. Published Amorim, M. H. R.; Gil da Costa, R. M.; Bastos, Margarida M. S. M.. "2D NMR Studies of sesquiterpene lactones with potential antitumoral activity". Paper presented in 3rd Portuguese Young Chemists Meeting – 3PYChem, Porto, 2012. Published Gil da Costa, R. M.; Bastos, Margarida M. S. M.; Oliveira, P.A.; Lopes, C.. "Toxic bracken (Pteridium aquilinum) constituents from mainland Portugal". Paper presented in 2nd Iberic Meeting of Veterinary Pathology, Lisboa, 2011. Published Gil da Costa, R. M.; Bastos, Margarida M. S. M.; Oliveira, P.A.; Lopes, C.. "Isolation of carcinogenic and cyanogenic bracken (Pteridium aquilinum) constituents from mainland Portugal specimens". Paper presented in 9th European Congress of Toxicological Pathology, Uppsala, 2011. Published Gil da Costa, R. M.; Oliveira, P.A.; Vilanova, M.; Bastos, Margarida M. S. M.; Lopes, Célia C.; Lopes, C.. "Ptaquiloside from bracken (P. aquilinum) induces a B-cell lymphoproliferative malignancy and urothelial dysplasia in mice". Paper presented in 9th European Congress of Toxicological Pathology, Uppsala, 2011. Published Gil da Costa, R. M.; Oliveira, P.A.; Vilanova, M.; Bastos, Margarida M. S. M.; Lopes, Célia C.; Lopes, C.. "Morphological and molecular characterization of ptaquiloside-induced neoplastic and pre-neoplastic lesions in mice". Paper presented in 2nd Iberic Meeting of Veterinary Pathology, Lisboa, 2011. Published Gil da Costa, R. M.; Coelho, Patrícia; Sousa, Rosa; Bastos, Margarida M. S. M.; Porto, Beatriz; Teixeira, João P.; Malheiro, Isabel; Lopes, C.. "Genotoxicity/clastogenicity of ptaquiloside, the bracken (Pteridium aquilinum) carcinogen, towards human peripheral blood lymphocytes". Paper presented in 21st Meeting of the European Association for Cancer Research, Oslo, 2010. Published Trigo, G.; Gil da Costa, R. M.; Dinis, M.; Franca, A.; Ferreira, P.; Tavares, D.. "Mammary gland increased inflammatory response in mice breastfed on Streptococcus agalactiae mastitis dams". Paper presented in 2nd European Congress of Immunology, Berlin, 2009. Published Gil da Costa, R. M.; Oliveira, J. P.; Saraiva, A. L.; Seixas, F.; Faria, F.; Gartner, F.; Pires, M. A.; Lopes, C.. "Immunohistochemical characterization of canine renal cell carcinomas". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Gil da Costa, R. M.; Pereira, J.; Bessa, J.; São José Nascimento, M.; Gartner, F.; Kijjoa, A.; Lopes, C.. "In vitro anti-tumour activity of two Pteridium aquilinum extracts". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Gil da Costa, R. M.; Santos, M.; Amorim, I.; Lopes, Célia C.; Dias Pereira, P.; Faustino, A.M.. "Immunophenotypical changes associated with feline endometrial neoplastic transformation". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Gil da Costa, R. M.; Watanabe, T.; Amorim, I.; Rema, A.; Lopes, Célia C.; Matos, Eduarda; Duarte, M.; Gartner, F.. "Feline post-vaccinal sarcoma: an immunohistochemical study". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Amorim, I.; Lopes, Célia C.; Gil da Costa, R. M.; Faustino, A.M.; Dias Pereira, P.. "Cav-1 immunoexpression in canine mammary tissues". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Amorim, I.; Lopes, Célia C.; Gil da Costa, R. M.; Faustino, A.M.; Dias Pereira, P.. "A case of gastric carcinoma with osseous metaplasia in a dog". Paper presented in 26th Meeting of the European Society of Veterinary Pathology, Dubrovnik, 2008. Published Trigo, G.; Franca, A.; Dinis, M.; Gil da Costa, R. M.; Bonifacio Andrade, E.; Ferreira, P.; Tavares, D.. "Inflammatory cell infiltration and inflammatory cytokines: indicators of Streptococcus agalactiae infection in experimental mouse mastitis". Paper presented in 18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, 2008. Published Correia, A.; Teixeira, L.; Cerca, F.; Botelho, S.; Sampaio, P.; Gil da Costa, R. M.; Gartner, F.; Pais, C.; Vilanova, M.. "Immunobiological characterization of murine Cândida albicans SC5314 systemic infection". Paper presented in Micro’07-Biotech’07-XXXIII JPG Congress, Lisboa, 2007. Published Gil da Costa, R. M.; Pinto, D.; Sousa, H.; Matos, Eduarda; Rema, A.; Lopes, Célia C.; Medeiros, R.; Pires, M. A.; Gartner, F.. "The role of KIT in canine mast cell tumours: a biopathological study". Paper presented in 25th Meeting of the European Society of Veterinary Pathology, Munique, 2007. Published Gil da Costa, R. M.; Silva, C.; Faria, F.; Gomes Neves, E.; Gartner, F.. "Histological and immunohistochemical characterization of a renal cell carcinoma in a pig". Paper presented in 25th Meeting of the European Society of Veterinary Pathology, Munique, 2007. Published Gil da Costa, R. M.; Lopes, Célia C.; Martins, L.; Pires, M. A.; Gartner, F.. "Immunohistochemical evaluation of a multicentric lymphoma and an intestinal carcinoid in a dog". Paper presented in 24th Meeting of the European Society of Veterinary Pathology, Edimburgo, 2006. Published Gil da Costa, R. M.; Rema, A.; Payo-Puente, P.; Gartner, F.. "Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus)". Paper presented in 21st Meeting of the European Society of Veterinary Dermatology, Lisboa, 2006. Published • 10.1016/j.jcpa.2006.04.006 Gil da Costa, R. M.; Lopes, Célia C.; Gartner, F.. "Mast Cell Tumour: a case report.". Paper presented in 23rd Meeting of the European Society of Veterinary Pathology, Nápoles, 2005. Published
Conference paper	Faustino-Rocha, A.I.; Rodrigues, D.; Gil da Costa, R.M.; Dinis, C.; Talhada, D.; Aragão, S.; Botelho, M.; et al. "Effects of Trihalomethanes on Liver Mitochondria". 2015. Joana Barbosa; Margarida M. S. M. Bastos; Gil da Costa, R. M.; D. Pinto; A. Silva. "Studies of sesquiterpene lactones with potential antitumoral activity: purification, characterization and synthesis of aminoderivatives". 2014. Faustino-Rocha A. I.; Silva, A.; Gabriel, J.; Talhada D; Andrade, A.; Teixeira-Guedes, C. I.; Gil da Costa, R. M.; et al. "A new approach to evaluate mammary tumours in female Sprague-Dawley rats: thermography.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published Teixeira-Guedes, C. I.; Andrade, A.; Talhada D; Faustino-Rocha A. I.; Gil da Costa, R. M.; Pires, Maria João; Gama, A.; et al. "Effects of moderate exercise in an animal model of chemically-induced mammary tumours.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published Faustino-Rocha, A.I.; Talhada D; Andrade, A.; Teixeira-Guedes, C. I.; Gil da Costa, R. M.; Ferreira, R.; Gama, A.; Oliveira, P.A.; Ginja, M.. "Evaluation of MNU-induced mammary tumours in female Sprague-Dawley rats by histology and contrast-enhanced ultrasound.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published Carneiro, M.; Nieto, R.; Brandão, R.; Gil da Costa, R. M.; Oliveira, P.A.; Lavin, S.. "Acute lead poisoning in a griffon vulture secondary to bullet ingestion.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published Soares-Maia, R.; Faustino-Rocha, A.I.; Teixeira-Guedes, C. I.; Pinho-Oliveira, J.; Rema, A.; Faria, F.; Ginja, M.; et al. "Histological and imunohistochemical features of MNU-induced rat mammary carcinomas.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published Teixeira-Guedes, C. I.; Faustino-Rocha, A.I.; Talhada D; Andrade, A.; Pacheco, R.; Gil da Costa, R. M.; Duarte, J. A.; et al. "Case report: a rat hepatic schwannoma.". Paper presented in 31st Meeting of the European Society of Veterinary Pathology, London, 2013. Published
Conference poster	Rocha, R; Lopes, I; Silva, F; Campos, C; Gil da Costa, R. M. ; Rocha, C; Lima, V; et al. "Brachydins from Arrabidaea brachypoda: antitumor effect against the A375-C5 melanoma cell line". Paper presented in 1st Young Researchers' Day, 2023. Rocha, R; Gil da Costa, R. M. ; da Rocha, C; Lima, V; Brito, H; Medeiros R; Cerqueira, Fátima. "Arrabidaea brachypoda: potencial anti-tumoral contra linhas celulares de melanoma". Paper presented in 5º ENJIO - ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA, 2023. Medeiros-Fonseca, B; Segurado, Olga; Costa, Diana; Medeiros, Catarina; Medeiros, Rui; Pires, Maria João; Bastos, M. M. S. M.; et al. "Efeito da aplicação repetida de Cytinus hypocistis em murganhos transgénicos (K14HPV16): avaliação de humane endpoints". Paper presented in Encontro com a Ciência e Tecnologia em Portugal, 2021.
Journal article	Faustino-Rocha, AI; Lima da Silva, L; Teles, AM; Santos, JMO; Souza de Andrade, M; Medeiros, R; Oliveira, PA; et al. "Malignancy associated with Low-Risk HPV6 and HPV11: a systematic review and implications for cancer prevention". Cancers (2024): http://hdl.handle.net/10174/36380. 10.3390/cancers15164068 Rui M. Gil da Costa; Christine Levesque; Daniella Bianchi-Frias; Payel Chatterjee; Hung-Ming Lam; Carlos Santos; Ilsa M. Coleman; et al. "Pharmacological NF-¿B inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities.". Molecular Oncology (2023): https://doi.org/10.1002/1878-0261.13504. 10.1002/1878-0261.13504 Jucileide Mota; Alice Marques Moreira Lima; Jhessica I. S. Gomes; Marcelo Souza de Andrade; Haissa O. Brito; Melaine M. A. Lawall Silva; Ana I. Faustino-Rocha; et al. "Klotho in Cancer: Potential Diagnostic and Prognostic Applications". Diagnostics (2023): https://doi.org/10.3390/diagnostics13213357. 10.3390/diagnostics13213357 Joana M. O. Santos; Valéria Tavares; Rui M. Gil da Costa; Rui Medeiros. "MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers". Biomarkers (2023): https://doi.org/10.1080/1354750X.2023.2269320. 10.1080/1354750X.2023.2269320 Walbert Edson Muniz Filho; Fernando Almeida-Souza; André Alvares Marques Vale; Elis Cabral Victor; Mirtes Castelo Branco Rocha; Gabriel Xavier Silva; Amanda Mara Teles; et al. "Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model". Cancers (2023): https://www.mdpi.com/2072-6694/15/9/2544. 10.3390/cancers15092544 Cochicho, Daniela; Nunes, Alexandra; Sobral, Daniel; Gomes, João P.; Esteves, Susana; Mendonça, Joana; Vieira, Luis; et al. "Distribution and Clinical Significance of HPV16 Variants in Head and Neck Squamous Cell Carcinomas: Data from a Portuguese Cohort and Systematic Review". (2023): http://hdl.handle.net/10400.18/8918. 10.1159/000529723 Tiago Azevedo; Tiago Ferreira; João Ferreira; Filipa Teixeira; Diana Ferreira; Rita Silva-Reis; Maria João Neuparth; et al. "Supplementation of an Anthocyanin-Rich Elderberry (Sambucus nigra L.) Extract in FVB/n Mice: A Healthier Alternative to Synthetic Colorants". Applied Sciences (2022): https://doi.org/10.3390/app122311928. 10.3390/app122311928 Carla M. Ribeiro-Silva; Ana I. Faustino-Rocha; Rui M. Gil da Costa; Rui Medeiros; Maria J. Pires; Isabel Gaivão; Adelina Gama; et al. "Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from Acute and Chronic Studies". Biomedicines (2022): https://doi.org/10.3390/biomedicines10102595. 10.3390/biomedicines10102595 Daniela Cochicho; Alexandra Nunes; Gomes JP; Luís Martins; Mario Cunha; Beatriz Medeiros-Fonseca; Paula Oliveira; et al. "Characterization of the Human Papillomavirus 16 Oncogenes in K14HPV16 Mice: Sublineage A1 Drives Multi-Organ Carcinogenesis". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/20/12371. 10.3390/ijms232012371 Alexandra C. Costa; Joana M. O. Santos; Beatriz Medeiros-Fonseca; Paula A. Oliveira; Margarida M. S. M. Bastos; Haissa O. Brito; Rui M. Gil da Costa; Rui Medeiros. "Characterizing the Inflammatory Microenvironment in K14-HPV16 Transgenic Mice: Mast Cell Infiltration and MicroRNA Expression". Cancers 14 9 (2022): 2216-2216. https://doi.org/10.3390/cancers14092216. 10.3390/cancers14092216 Daniela Cochicho; Susana Esteves; Miguel Rito; Fernanda Silva; Luís Martins; Pedro Montalvão; Mário Cunha; et al. "PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival". Cancers (2022): https://doi.org/10.3390/cancers14051286. 10.3390/cancers14051286 Ana Mafalda Rasteiro; Eva Sá e Lemos; Paula A. Oliveira; Rui M. Gil da Costa. "Molecular Markers in Urinary Bladder Cancer: Applications for Diagnosis, Prognosis and Therapy". Veterinary Sciences (2022): https://doi.org/10.3390/vetsci9030107. 10.3390/vetsci9030107 Santos, J.M.O.; Peixoto da Silva, S.; Bastos, M.M.S.M.; Oliveira, P.A.; Gil da Costa, R.M.; Medeiros, R.. "Decoding the role of inflammation-related microRNAs in cancer cachexia: a study using HPV16-transgenic mice and in silico approaches". Journal of Physiology and Biochemistry 78 2 (2022): 439-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126353961&partnerID=MN8TOARS. 10.1007/s13105-021-00866-1 Medeiros-Fonseca, B.; Abreu-Silva, A.L.; Medeiros, R.; Oliveira, P.A.; Gil da Costa, R.M.. 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"An Update on Canine, Feline and Bovine Papillomaviruses". Transboundary and Emerging Diseases 64 5 (2017): 1371-1379. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993945048&partnerID=MN8TOARS. 10.1111/tbed.12555 Da Costa, R.M.G.; Araujo, R.; Santos, J.M.O.; Fernandes, M.; Neto, T.; Sousa, H.; Ribeiro, J.; et al. "Regulation of miRNA-146a and miRNA-150 Levels by celecoxib in premalignant lesions of K14-HPV16 mice". Anticancer Research 37 6 (2017): 2913-2918. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019702645&partnerID=MN8TOARS. 10.21873/anticanres.11644 Alvarado, A.; Gil da Costa, R.M.; Faustino-Rocha, A.I.; Ferreira, R.; Lopes, C.; Oliveira, P.A.; Colaço, B.. "Effects of exercise training on breast cancer metastasis in a rat model". International Journal of Experimental Pathology 98 1 (2017): 40-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019680903&partnerID=MN8TOARS. 10.1111/iep.12225 Santos, C.; Vilanova, M.; Medeiros, R.; Gil da Costa, R.M.. "HPV-transgenic mouse models: Tools for studying the cancer-associated immune response". Virus Research 235 (2017): 49-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018511205&partnerID=MN8TOARS. 10.1016/j.virusres.2017.04.001 Santos, J.M.O.; Fernandes, M.; Araújo, R.; Sousa, H.; Ribeiro, J.; Bastos, M.M.S.M.; Oliveira, P.A.; et al. "Dysregulated expression of microRNA-150 in human papillomavirus-induced lesions of K14-HPV16 transgenic mice". Life Sciences 175 (2017): 31-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016497356&partnerID=MN8TOARS. 10.1016/j.lfs.2017.03.008 Pires, MA; Gama, A; Pires, I; Seixas, F; Prada, J; Pinto, ML; Branco, S; et al. "Establishment of antibody panels and histochemical techniques in routine tumor diagnosis in Veterinary Pathology". (2017): http://hdl.handle.net/10174/19767. Santos, C.; Ferreirinha, P.; Sousa, H.; Ribeiro, J.; Bastos, M.M.S.M.; Neto, T.; Oliveira, P.A.; et al. "Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8⁺ T cells in HPV-16 transgenic mice". Food and Chemical Toxicology 97 (2016): 277-285. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988650893&partnerID=MN8TOARS. 10.1016/j.fct.2016.09.019 Santos, C.; Neto, T.; Ferreirinha, P.; Sousa, H.; Ribeiro, J.; Bastos, M.M.S.M.; Faustino-Rocha, A.I.; et al. "Celecoxib promotes degranulation of CD8⁺T cells in HPV-induced lesions of K14-HPV16 transgenic mice". Life Sciences 157 (2016): 67-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974678418&partnerID=MN8TOARS. 10.1016/j.lfs.2016.05.040 Oliveira, P.A.; Gil da Costa, R.M.; Vasconcelos-Nóbrega, C.; Arantes-Rodrigues, R.; Pinto-Leite, R.. "Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery". Expert Opinion on Drug Discovery 11 6 (2016): 599-607. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969217029&partnerID=MN8TOARS. 10.1080/17460441.2016.1174690 Faustino-Rocha, A.I.; Silva, A.; Gabriel, J.; Gil da Costa, R.M.; Moutinho, M.; Oliveira, P.A.; Gama, A.; Ferreira, R.; Ginja, M.. "Long-term exercise training as a modulator of mammary cancer vascularization". Biomedicine and Pharmacotherapy 81 (2016): 273-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963865493&partnerID=MN8TOARS. 10.1016/j.biopha.2016.04.030 Da Costa, R.M.G.; Bastos, M.M.S.M.; Medeiros, R.; Oliveira, P.A.; Rui M. Gil da Costa; Margarida M. S. M. Bastos; Rui Medeiros; Paula A. Oliveira. "The NFkB signaling pathway in papillomavirus-induced lesions: Friend or foe?". Anticancer Research 36 5 (2016): 2073-2083. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988310767&partnerID=MN8TOARS. Costa, Céu; Pereira, Sofia; Lima, Luís; Peixoto, Andreia; Fernandes, Elisabete; Neves, Diogo; Neves, Manuel; et al. "Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics". PLOS ONE 10 11 (2015): e0141253-e0141253. Published • 10.1371/journal.pone.0141253 Gil da Costa, Rui M; Oliveira, Paula A.; Vasconcelos-Nóbrega, Carmen; Arantes-Rodrigues, Regina; Pinto-Leite, Rosário; Colaço, Aura A.; de la Cruz, Luis F.; Lopes, Carlos. "Altered expression of CKs 14/20 is an early event in a rat model of multistep bladder carcinogenesis". International Journal of Experimental Pathology 96 5 (2015): 319-325. Published • 10.1111/iep.12145 Gil da Costa, Rui M. "C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic". The Veterinary Journal 205 1 (2015): 5-10. Published • 10.1016/j.tvjl.2015.05.002 Faustino-Rocha, Ana I.; Rodrigues, D.; da Costa, R. Gil; Diniz, C.; Aragão, S.; Talhada, D.; Botelho, M.; et al. "Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse". Environmental Toxicology 0 (2015): Accepted • 10.1002/tox.22110 Paiva, Isabel; Gil da Costa, Rui M; Ribeiro, Joana; Sousa, Hugo; Bastos, Margarida M.S.M.; Faustino-Rocha, Ana; Lopes, Carlos; Oliveira, Paula A.; Medeiros, Rui. "MicroRNA-21 expression and susceptibility to HPV-induced carcinogenesis — role of microenvironment in K14-HPV16 mice model". Life Sciences 128 (2015): 8-14. Published • 10.1016/j.lfs.2015.02.020 Paiva, Isabel; Gil da Costa, Rui M; Ribeiro, Joana; Sousa, Hugo; Bastos, Margarida; Rocha, Ana Faustino Carlos; Oliveira, Paula A.; Medeiros, Rui; Calin, George. "A Role for MicroRNA-155 Expression in Microenvironment Associated to HPV-Induced Carcinogenesis in K14-HPV16 Transgenic Mice". PLOS ONE 10 1 (2015): e0116868-e0116868. Published • 10.1371/journal.pone.0116868 Antonieta Alvarado; Arantes-Rodrigues, Regina; Vasconcelos-Nóbrega, C.; Gil da Costa, R. M.; Pinto-Leite, Rosário; Faustino-Rocha A. I.; Oliveira, Paula A.. "Carcinogénesis química de vejiga urinaria en roedores de laboratorio como modelo experimental.". Revista Venezolana de Oncologia 27 (2015): 57-63. Published Alvarado, A.; Arantes-Rodrigues, R.; Vasconcelos-Nóbrega, C.; Da Costa, R.G.; Pinto-Leite, M.R.; Faustino-Rocha, A.I.; Oliveira, P.A.; et al. "Urinary bladder chemical carcinogenesis in laboratory rodents as an experimental model,Carcinogénesis química de vejiga urinaria en roedores de laboratorio como modelo experimental". Revista Venezolana de Oncologia 27 1 (2015): 57-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921047220&partnerID=MN8TOARS. Talhada, D.; Andrade, A.; Faustino-Rocha, A.I.; Teixeira-Guedes, C.I.; Teixeira, J.H.; Arantes-Rodrigues, R.; Vasconcelos-Nóbrega, C.; Gil da Costa, R.M.; Oliveira, P.A.. "Recommendations for urine and urinary bladder collection in chemical carcinogenesis assays with rodents". Scandinavian Journal of Laboratory Animal Science 41 8 (2015): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954516402&partnerID=MN8TOARS. Gil da Costa, R.M.; Oliveira, P.A.; Bastos, M.M.S.M.; Lopes, C.C.; Lopes, C.. "Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact ß-catenin and E-cadherin expression". Environmental Toxicology 29 7 (2014): 763-769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901823017&partnerID=MN8TOARS. Published • 10.1002/tox.21803 Santos, N.P.; Oliveira, P.A.; Arantes-Rodrigues, R.; Faustino-Rocha, A.I.; Colaço, A.; Lopes, C.; Gil da Costa, R.M.. "Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: Implications for histogenesis". International Journal of Experimental Pathology 95 3 (2014): 191-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900485588&partnerID=MN8TOARS. Published • 10.1111/iep.12082 Gil da Costa, R.M.; Medeiros, R.. "Bovine papillomavirus: Opening new trends for comparative pathology". Archives of Virology 159 2 (2014): 191-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895072812&partnerID=MN8TOARS. Published • 10.1007/s00705-013-1801-9 Paula Santos, N.; Colaço, A.; Gil da Costa, R.M.; Manuel Oliveira, M.; Peixoto, F.; Alexandra Oliveira, P.. "N-diethylnitrosamine mouse hepatotoxicity: Time-related effects on histology and oxidative stress". Experimental and Toxicologic Pathology 66 9-10 (2014): 429-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908495769&partnerID=MN8TOARS. Published • 10.1016/j.etp.2014.07.002 Da Costa, R.M.G.; Paula-Santos, N.; Rocha, A.F.; Colaç, A.; Lopes, C.; Oliveira, P.A.; Rui M. Gil da Costa; et al. "The N-nitrosodiethylamine mouse model: Sketching a timeline of evolution of chemically-induced hepatic lesions". Anticancer Research 34 12 (2014): 7029-7037. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918540346&partnerID=MN8TOARS. Published Talhada D; Andrade, A.; Faustino-Rocha A. I.; Teixeira-Guedes, C. I.; Teixeira, J. H.; Arantes-Rodrigues, R.; Vasconcelos-Nóbrega, C.; Gil da Costa, R. M.; Oliveira, P.A.. "Recommendations for urine and urinary bladder collection in rodents chemical carcinogenesis assays.". Scandinavian Journal of Laboratoy Animal Science - (2013): ---. Published Arantes-Rodrigues, Regina; Pinto-Leite, Rosário; Costa, Rui Gil; Colaço, Aura; Lopes, Carlos; Oliveira, Paula. "Cytogenetic characterization of an N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse papillary urothelial carcinoma". Tumor Biology - (2013): ---. Published • 10.1007/s13277-013-0820-1 Amorim, M. Helena R.; Gil da Costa, Rui M; Lopes, Carlos; Bastos, Margarida M. S. M.. "Sesquiterpene lactones: Adverse health effects and toxicity mechanisms". Critical Reviews in Toxicology 43 7 (2013): 559-579. Published • 10.3109/10408444.2013.813905 Faustino-Rocha, A.I.; Silva, A.; Gabriel, J.; Teixeira-Guedes, C.I.; Lopes, C.; Gil da Costa, R.; Gama, A.; et al. "Ultrasonographic, thermographic and histologic evaluation of MNU-induced mammary tumors in female Sprague-Dawley rats". Biomedicine & Pharmacotherapy - (2013): ---. Published • 10.1016/j.biopha.2013.06.011 Faustino-Rocha, Ana; Oliveira, Paula A.; Pinho-Oliveira, Jacinta; Teixeira-Guedes, Catarina; Soares-Maia, Ruben; da Costa, Rui Gil; Colaço, Bruno; et al. "Estimation of rat mammary tumor volume using caliper and ultrasonography measurements". Lab Animal 42 6 (2013): 217-224. Published • 10.1038/laban.254 Soares-Maia, R.; Faustino-Rocha, A.I.; Teixeira-Guedes, C.I.; Pinho-Oliveira, J.; Talhada, D.; Rema, A.; Faria, F.; et al. "MNU-induced rat mammary carcinomas: Immunohistology and estrogen receptor expression". Journal of Environmental Pathology, Toxicology and Oncology 32 2 (2013): 157-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884166153&partnerID=MN8TOARS. Published • 10.1615/JEnvironPatholToxicolOncol.2013007541 Gil da Costa, R.M.; Bastos, M.M.S.M.; Oliveira, P.A.; Lopes, C.. "Bracken-associated human and animal health hazards: Chemical, biological and pathological evidence". Journal of Hazardous Materials 203 204 (2012): 1-12. Published • 10.1016/j.jhazmat.2011.12.046 Amorim, I.; Lopes, C.; da Costa, R.G.; Faustino, A.M.; Gärtner, F.; Pereira, P.D.; Faustino, A.. "Gastric carcinoma with osseous metaplasia in a dog". Archives of Veterinary Science 17 3 (2012): 10-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875115163&partnerID=MN8TOARS. Published Pértile, R.A.N.; Moreira, S.; Gil Da Costa, R.M.; Correia, A.; Guardão, L.; Gartner, F.; Vilanova, M.; Gama, M.. "Bacterial cellulose: Long-term biocompatibility studies". Journal of Biomaterials Science, Polymer Edition 23 10 (2012): 1339-1354. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867215936&partnerID=MN8TOARS. Published • 10.1163/092050611X581516 Gil da Costa, R.M.; Coelho, P.; Sousa, R.; Bastos, M.M.S.M.; Porto, B.; Teixeira, João Paulo; Malheiro, I; et al. "Multiple genotoxic activities of ptaquiloside in human lymphocytes: aneugenesis, clastogenesis and induction of sister chromatid exchange". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 747 (2012): 77-81. http://hdl.handle.net/10400.18/1203. Published • doi: 10.1016/j.mrgentox.2012.04.010 Gil da Costa, Rui M.; Oliveira, Paula A.; Vilanova, Manuel; Bastos, Margarida M.S.M.; Lopes, Célia C.; Lopes, Carlos. "Ptaquiloside-induced, B-cell lymphoproliferative and early-stage urothelial lesions in mice". Toxicon 58 6-7 (2011): 543-549. Published • 10.1016/j.toxicon.2011.08.016 Simões, M.J.; Gärtner, A.; Shirosaki, Y.; Gil Da Costa, R.M.; Cortez, P.P.; Gartnër, F.; Santos, J.D.; et al. "In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction \| Avaliação in vivo e in vitro de membranas de quitosano para utilização em reconstrução de nervo periférico". Acta Medica Portuguesa 24 1 (2011): 43-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953291301&partnerID=MN8TOARS. Published Gil da Costa, R.M.; Oliveira, J.P.; Saraiva, A.L.; Seixas, F.; Faria, F.; Gärtner, F.; Pires, M.A.; Lopes, C.. "Immunohistochemical characterization of 13 canine renal cell carcinomas". Veterinary Pathology 48 2 (2011): 427-432. Published Gil da Costa, R.M.; Oliveira, J.P.; Saraiva, A.L.; Seixas, F.; Faria, F.; Gärtner, F.; Pires, M.A.; Lopes, C.. "Immunohistochemical characterization of 13 canine renal cell carcinomas". Veterinary Pathology 48 2 (2011): 427-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953778001&partnerID=MN8TOARS. 10.1177/0300985810381909 Simões, M J; Gärtner, A; Shirosaki, Y; Gil da Costa, R M; Cortez, P P; Gartnër, F; Santos, J D; et al. "In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction.". (2011): https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/344. Correia, A.; Lermann, U.; Teixeira, L.; Cerca, F.; Botelho, S.; Gil da Costa, R. M.; Sampaio, P.; et al. "Limited Role of Secreted Aspartyl Proteinases Sap1 to Sap6 in Candida albicans Virulence and Host Immune Response in Murine Hematogenously Disseminated Candidiasis". Infection and Immunity 78 11 (2010): 4839-4849. https://hdl.handle.net/10216/103325. Published • 10.1128/IAI.00248-10 Gil da Costa, R.M.; Rema, A.; Pires, M.A.; Gärtner, F.. "Two canine Merkel cell tumours: Immunoexpression of c-KIT, E-cadherin, ß-catenin and S100 protein". Veterinary Dermatology 21 2 (2010): 198-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951189196&partnerID=MN8TOARS. Published • 10.1111/j.1365-3164.2009.00768.x Moreira, S.; Gil Da Costa, R.M.; Guardáo, L.; Gärtner, F.; Vilanova, M.; Gama, M.. "In vivo biocompatibility and biodegradability of dextrin-based hydrogels". Journal of Bioactive and Compatible Polymers 25 2 (2010): 141-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749251868&partnerID=MN8TOARS. Published • 10.1177/0883911509357865 Gil da Costa, R.M.; Santos, M.; Amorim, I.; Lopes, C.; Pereira, P. Dias; Faustino, A.M.. "An Immunohistochemical Study of Feline Endometrial Adenocarcinoma". Journal of Comparative Pathology 140 4 (2009): 254-259. Published • 10.1016/j.jcpa.2008.12.006 Trigo, G.; Dinis, M.; Franca, A.; Bonifacio Andrade, E.; Gil da Costa, R. M.; Ferreira, P.; Tavares, D.. "Leukocyte populations and cytokine expression in the mammary gland in a mouse model of Streptococcus agalactiae mastitis". Journal of Medical Microbiology 58 7 (2009): 951-958. Published • 10.1099/jmm.0.007385-0 Gil da Costa, R.M.; Rema, A.; Payo-Puente, P.; Gärtner, F.. "Immunohistochemical Characterization of a Sebaceous Gland Carcinoma in a Gerbil (Meriones unguiculatus)". Journal of Comparative Pathology 137 2-3 (2007): 130-132. Published • 10.1016/j.jcpa.2006.04.006 Gil da Costa, Rui M; Matos, Eduarda; Rema, Alexandra; Lopes, Célia; Pires, Maria A; Gärtner, Fátima. "CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers". BMC Veterinary Research 3 1 (2007): 19-19. Published • 10.1186/1746-6148-3-19
Manual	Teixeira, C.; Faustino, A.; Andrade, A.; Andrade, D.; Teixeira J.; Arantes, R.; Vasconcelos-Nóbrega, C.; Gil da Costa, R. M.; Oliveira, P.A.. Colheita de urina e recolha da bexiga em ensaios experimentais de carcinogénese química em roedores.. Portugal. 2013.
Preprint	Diana C. DeLucia; Thomas M. Cardillo; Lisa Ang; Mark P. Labrecque; Ailin Zhang; James E. Hopkins; Navonil De Sarkar; et al. "Supplementary Tables 1-4 from Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5–SN38 Antibody–drug Conjugate in Neuroendocrine Prostate Cancer". 2023. https://doi.org/10.1158/1078-0432.22479233. 10.1158/1078-0432.22479233 Daniella Bianchi-Frias; Mamatha Damodarasamy; Susana A. Hernandez; Rui M. Gil da Costa; Funda Vakar-Lopez; Ilsa M. Coleman; May J. Reed; Peter S. Nelson. "Data from The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells". 2023. https://doi.org/10.1158/1541-7786.c.6541111. 10.1158/1541-7786.c.6541111 Daniella Bianchi-Frias; Mamatha Damodarasamy; Susana A. Hernandez; Rui M. Gil da Costa; Funda Vakar-Lopez; Ilsa M. Coleman; May J. Reed; Peter S. Nelson. "Data from The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells". 2023. https://doi.org/10.1158/1541-7786.c.6541111.v1. 10.1158/1541-7786.c.6541111.v1
Thesis / Dissertation	Oliveira, Rui Miguel Gil da Costa. "Studies on the biopathological actions of Pteridium aquilinum". PhD, 2012. http://hdl.handle.net/10216/63596.

Other

Other output

Penicillium purpurogenum exerts antitumor effects and ameliorates inflammations in erlich mice model. 2020. Teles, A.M.; Pereira Pontes, L.P.; Araujo Guimarães, S.J.; de Araújo Butarelli, A.L.; Silva, G.X.; Fernandes do Nascimento, F.R.; de Barros Bezerra, G.F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098830237&partnerID=MN8TOARS.
10.1101/2020.07.02.184291
Studies on the biopathological actions of Pteridium aquilinum. Tese de Doutoramento em Ciências Biomédicas. 2012. Gil da Costa, R. M..
Mastocitoma cutâneo canino: estudos biopatológicos. Tese de Mestrado em Oncologia. 2007. Gil da Costa, R. M..
Isolamento e mapeamento físico de uma sequência de DNA satélite – CAFCA I – de Felis catus. Aplicações futuras na área clínica ao nível do diagnóstico. Relatório final de Licenciatura.. 2003. Gil da Costa, R. M..

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	Estudo de mutações dos genes Nsd1, Nsd2 e Nsd3 em camundongos transgênicos para o papilomavírus humano tipo 16 Co-supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2022 - Current	Avaliação de marcadores imunes em carcinoma peniano Co-supervisor	Programa de Pós-Graduação em Ciências da Saúde (Master) Universidade Federal do Maranhão, Brazil
2021 - Current	Estudo dos efeitos imunossupressores de Pteridium aquilinum e suas contribuições para o processo de carcinogénese induzido por papilomavírus Co-supervisor	Programa Doutoral em Ciências Veterinárias (PhD) Universidade de Trás-os-Montes e Alto Douro, Portugal
2022 - 2023	CÂNCER DE PÊNIS: ANÁLISE DO PERFIL DE PACIENTES EM ÁREA DE ALTA INCIDÊNCIA REFORÇA A IDEIA DE DUAS VIAS FISIOPATOLÓGICAS Supervisor	Medicina (Degree) Universidade Federal do Maranhão, Brazil
2021 - 2023	Molecular characterization of adipose tissue in cachexia Co-supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2023	Caracterização do microambiente tumoral do câncer de pênis: implicações clínico-patológicas de alterações nos compartimentos epitelial e estromal de lesões HPV-positivas e HPV-negativas Supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2020 - 2023	HPV16 variants in head and neck carcinomas Co-supervisor	Programa Doutoral em Ciências Médicas (PhD) Universidade Nova de Lisboa Medical School, Portugal
2020 - 2023	Decoding the role of neutrophils and microRNAs as drivers of HPV16-induced carcinogenesis and cancer cachexia Co-supervisor	Doutoramento em Biomedicina (PhD) Universidade do Porto Faculdade de Medicina, Portugal
2020 - 2022	Interação da via de sinalização ROBO/SLIT na co-infecção com HPV em tumores penianos e sua correlação com a carcinogênese. Supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2020 - 2022	Expressão de metaloproteinases e seus inibidores endógenos em câncer de pênis: estudos clínico-patológicos e relação com a infecção pelo HPV Supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2020 - 2021	Estágio Pós-doutoral - Estudo do papel do HPV na carcinogénese em tumores comuns no estado do Maranhão Supervisor	Universidade Federal do Maranhão, Brazil
2020 - 2021	Expressão de imune checkpoints em câncer de pênis: relação com o vírus do papiloma humano Supervisor	Universidade Federal do Maranhão, Brazil
2020 - 2021	Estudo do envolvimento do papilomavírus humano na doença arterial coronariana. Supervisor	Universidade Federal do Maranhão, Brazil
2019 - 2021	Klotho no câncer – uma revisão sistemática Supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2019 - 2021	HPV6 e HPV11: virus de baixo risco envolvidos na transformação maligna? Supervisor	Programa de Pós-Graduação em Saúde do Adulto (Master) Universidade Federal do Maranhão, Brazil
2020 - 2020	ESTUDO DA CARCINOGÉNESE PENIANA INDUZIDA PELO VÍRUS DO PAPILOMA HUMANO TIPO 16 (HPV16) NUM MODELO MURINO Supervisor	Genética Molecular Comparativa e Tecnológica (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2020 - 2020	AVALIAÇÃO IN VIVO DE EFEITOS FISIOLÓGICOS DA SUPLEMENTAÇÃO ALIMENTAR DE UMA ALGA MARINHA, GRATELOUPIA TURUTURU EM MURGANHOS K14HPV16 Supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2020 - 2020	STUDY OF OROPHARYNGEAL CARCINOGENESIS INDUCED BY HUMAN PAPILLOMA VIRUS TYPE 16 (HPV16) IN A MURINE MODEL Supervisor	Genética Molecular Comparativa e Tecnológica (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2019 - 2020	Estudo da Expressão de immune checkpoints em câncer de pênis. Supervisor	Universidade Federal do Maranhão, Brazil
2018 - 2020	The role of microRNAs and immune cells infiltration in susceptibility to HPV-induced carcinogenesis: studies in K14-HPV16 transgenic mice. Co-supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2020	Identification of dysregulated long non-coding RNAs in HPV-induced carcinogenesis and cancer cachexia Co-supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2020	Efeito de um extracto de folhas de hortelã-pimenta (Mentha spicata) em murganhos K14HPV16 Co-supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2018 - 2020	Development of an HPV16-transgenic mouse model of penile cancer Co-supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2018 - 2020	Efeitos fisiológicos da suplementação oral de uma alga da costa portuguesa em murganhos K14HPV16 Supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2018 - 2020	Characterizing a mouse model of HPV-related oropharyngeal cancer: observations from HPV16-transgenic mice Supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2019 - 2019	AVALIAÇÃO IN VIVO DE EFEITOS DA SUPLEMENTAÇÃO ALIMENTAR DE UMA ALGA MARINHA, PORPHYRA UMBILICALIS, EM MURGANHOS K14HPV16 Co-supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2017 - 2019	Dysregulated miRNA expression in HPV-induced carcinogenesis and cancer cachexia: let-7b, miR-21 and miR-301a expression in the K14-HPV16 mouse model Co-supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2019	Avaliação in vivo de efeitos antigenotóxicos da suplementação alimentar com algas marinhas em murganhos K14HPV16 Co-supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2017 - 2019	Oncogenic human papillomavirus E6 detection in the K14-HPV16 mouse model Co-supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2019	Inflamação e cancro: estudo da expressão da COX-2 em lesões pré-neoplásicas de murganhos transgénicos K14-HPV16 Supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2016 - 2018	Cancer and chemotherapy-induced muscle wasting: exploring the underlying mechanisms Supervisor	Medicina e Oncologia Molecular (Master) Universidade de Aveiro, Portugal
2017 - 2017	INFLAMAÇÃO E CANCRO: ESTUDO DA EXPRESSÃO DA COX-2 EM LESÕES PRÉ-NEOPLASICAS DE MURGANHOS TRANSGÉNICOS K14-HPV16 Supervisor	Bioquímica (Master) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2016 - 2017	Interferência do extrato do loureiro em parâmetros fisiológicos de murganhos geneticamente modificados (K14HPV16) Co-supervisor	Genética e Biotecnologia (Degree) Universidade de Trás-os-Montes e Alto Douro, Portugal
2016 - 2017	Efeito da administração do ozono em murganhos K14HPV16 Co-supervisor	Genética e Biotecnologia (Degree) Universidade de Trás-os-Montes e Alto Douro, Portugal
2016 - 2016	Análise da expressão do microrna-146a em murganhos transgénicos K14-HPV16 Supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2016	Análise da expressão do miRNA-146a em murganhos transgénicos K14-HPV16 Supervisor	Medicina e Oncologia Molecular (Master) Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2016	Expression profile of microRNA-150 in human papillomavirus-induced lesions of K14HPV16 transgenic mice Co-supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2016	Estudo in vivo da carcinogénese induzida pelo vírus do papiloma humano tipo 16 Supervisor	Biotecnologia para as Ciências da Saúde (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2015 - 2015	Modulating The CD8+ T Cell Response in Human Papillomavirus-Induced Lesions: Studies in The K14-HPV16 Transgenic Mouse Model Supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2015	Modulating the CD8+ T cell response in papillomavirus-induced lesions: studies in a transgenic mouse model Supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2014	Ptaquiloside, a natural compound with toxicological interest: monitoring and optimization of isolation Co-supervisor	Engenharia Química (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2012 - 2014	Análise da expressão de microRNAs em murganhos transgénicos K14-HPV16: implicações na carcinogénese induzida por HPV Co-supervisor	Oncologia (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2013	Acompanhamento em biotério e genotipagem de animais transgénicos Co-supervisor	Licenciatura em Genética e Biotecnologia (Degree) Universidade de Trás-os-Montes e Alto Douro, Portugal
2012 - 2013	Acompanhamento em biotério e genotipagem de animais transgénicos Supervisor	Genética e Biotecnologia (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2013	Impact of ADAM17 expression as a Potential Prognostic Biomarker and Target for Therapy in Node-negative Breast Carcinoma	Regina Sam (Master) Universidade do Porto, Portugal
2012	Análise imuno-histológica de tumores da mama induzidos quimicamente com N-metil-N-nitrosureia	Ruben Miguel Maia Soares (Master) Universidade do Porto, Portugal
2012	Avaliação de fatores de prognóstico associados a sarcomas excisados cirurgicamente de locais de inoculação em felinos	Daiana Rodrigues Cardoso (Master)

Association member

	Society Organization name	Role
Current	Ordem dos Médicos Veterinários
Current	European Society of Veterinary Pathology
Current	European Association for Cancer Research
Current	Liga Portuguesa de Profilaxia Social
Current	Sociedade Portuguesa de Patologia Animal
2003/09 - 2005/02	Royal College of Veterinary Sugeons

Consulting

	Activity description	Institution / Organization
2020 - 2023	Consultor ad-hoc para avaliaçãode projectos científicos (chamadas 006/2016 IGUALDADE RACIAL e 31/2016 - UNIVERSAL).	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão, Brazil
2022 - 2022	Avaliaçãode projectos científicos para o Austrian Science Fund (FWF)	Fonds zur Förderung der wissenschaftlichen Forschung, Austria
2020 - 2020	Avaliação de projectos científicos para a FUNCAP na chamada 2/2020 Programa Pesquisa para o SUS: gestão compartilhada em Saúde/PPSUS – CE FUNCAP-SESA-Decit/SCTIE/MS-CNPq.	Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico, Brazil

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024 - Current	Embriologia Especial	Odontologia (Licence)	Universidade Federal do Maranhão, Brazil
2024 - Current	Morfologia do Corpo Humano I	Farmácia (Licence)	Universidade Federal do Maranhão, Brazil
2020 - Current	Working with Laboratory Animals	(Master)	Universidade Federal do Maranhão, Brazil
2019 - Current	Citologia e Histologia	Nutrição (Licence)	Universidade Federal do Maranhão, Brazil
2012/09 - Current	Laboratórios Integrados I	(Outros)	Universidade do Porto, Portugal
2012/09 - Current	Biologia Celular	(Outros)	Universidade Lusófona, Portugal
2012/09 - Current	Inspecção Sanitária I	(Outros)	Universidade Lusófona, Portugal
2011/09 - 2012/02	Anatomia Patológica I	(Outros)	Universidade do Porto, Portugal
2012 - 2012	Papilomavírus bovinos - novas abordagens para velhos problemas	Aperfeiçoamento (Curso médio)	Universidade de Trás-os-Montes e Alto Douro, Portugal
2012 - 2012	Carcinogénese oro-esofágica: dos bovinos ao Homem	Aperfeiçoamento (Curso médio)	Instituto Português de Oncologia Francisco Gentil, Portugal
2007/03 - 2008/07	Patologia Geral	(Outros)	Universidade do Porto, Portugal
2005/02 - 2006/07	Saúde Pública Veterinária	(Outros)	Universidade de Trás-os-Montes e Alto Douro, Portugal

Distinctions

Award

2023	best poster award Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2022	Best MSc thesis award Universidade do Porto Faculdade de Medicina, Portugal
2021	Best abstract award Universidade do Minho, Portugal

Other distinction

2018	Inaugural Fellowship in support of an outstanding and collaborative pathologist
2018	Menção honrosa
2018	Menção honrosa
2017	Diploma de Honra ao Mérito Científico
2015	Poster Presentation Award
2007	"Travel award" to present his work: Gil da Costa, R.M et al. (2007) The role of KIT in canine mast cell tumours: a biopathological study in Munich, Germany..
2003	Inácio Ribeiro Sociedade Portuguesa de Ciências Veterinárias, Portugal
2003	Nunes Petisca Sociedade Portuguesa de Ciências Veterinárias, Portugal
2003	Prémio Inácio Ribeiro Sociedade Portuguesa de Ciências Veterinárias, Portugal
2003	Prémio Nunes Petisca Sociedade Portuguesa de Ciências Veterinárias, Portugal