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Ana M. Urbano, D. Phil, is an Assistant Professor in the Department of Life Sciences at the University of Coimbra, Portugal, and a Senior Scientist at the Molecular Physical Chemistry Research Unit of the same university. She is currently teaching courses on Biochemistry, Physical Chemistry and Laboratorial Biochemistry. She graduated in Biochemistry at the University of Coimbra (1989), where she later gained her MSc in Cell Biology (1993). Part of her MSc research was conducted, as an Erasmus student, at Delft Technical University. She then received a D. Phil from the University Cambridge, UK (1999), where she conducted research on mammalian cell bioenergetics. Her main research interest are the molecular and cellular mechanisms of carcinogenesis, with a special emphasis on bioenergetics. Her group has been investigating the impact of hexavalent chromium [Cr(VI)] on the energy metabolism of human lung cells and on their resistance to stress, aiming at a better understanding of the molecular mechanisms underlying the toxicity of this occupational lung carcinogen. Other research interests include the mechanisms by which exercise contributes to cancer prevention and improved management. Her strong interest in (onco)metabolism led her to (co)organise the 16th Charles Heidelberger Symposium on Cancer Research (2010) and two editions (2017 and 2019) of a FEBS Advanced Lecture Course devoted to oncometabolism. Ana Urbano has supervised 19 graduation projects and 16 MSc/PhD theses (11 completed), (co)authored 25+ peer-reviewed research papers/reviews/book chapters. She has recently co-edited a special issue for Biochimica Biophysica Acta-Molecular Basis of Disease (Oncometabolism: The Switchboard of Cancer). She has also been an ad-hoc reviewer for 15 different scientific journals and 1 funding agency.
Identification

Personal identification

Full name
Ana Margarida Malaquias Pires Urbano

Citation names

  • Urbano, Ana
  • A. M. Urbano
  • Ana Margarida Urbano
  • Ana M. Urbano

Author identifiers

Ciência ID
0211-9555-BD1F
ORCID iD
0000-0002-5197-1697

Email addresses

  • amurbano@ci.uc.pt (Professional)
  • amurbano@uc.pt (Professional)

Addresses

  • Department of Life Sciences, University of Coimbra. Calçada Martim de Freitas, 3000-456, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1)
French Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Proficiency (C2) Elementary (A2) Intermediate (B1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
1994/10 - 1999/01
Concluded
Biochemistry (Doctor of Philosophy)
University of Cambridge Department of Biochemistry, United Kingdom
"Genetic Manipulation of Energy Metabolism in Mammalian Cells" (THESIS/DISSERTATION)
1989 - 1993/01
Concluded
MSc in Cell Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"NMR Study of Gadolinium(III) Chelates with DTPA Bis(Amide) Derivatives): Neutral Contrast Agents for Magnetic Resonance Imaging (in Portuguese)" (THESIS/DISSERTATION)
1985/09 - 1989
Concluded
BSc in Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"NMR and Fluorescence Studies of Lanthanide Complexes with Bifunctional Derivatives of aminopolycarboxylates: Contrast Agents for Magnetic Resonance Imaging (in Portuguese)." (THESIS/DISSERTATION)
1982 - 1985
Concluded
Secondary School (Ensino secundário)
Major in Quimiotecnia
Escola Secundária Infanta D. Maria, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
1999/04 - Current Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1993/02/01 - 1999/04/01 Assistant (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1989/12/22 - 1993/01/31 Trainee Assistant (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

Category
Host institution
Employer
1999 - 2009 Member of the Scientific Committee of the Department of Biochemistry Universidade de Coimbra, Portugal
Universidade de Coimbra Departamento de Bioquímica, Portugal
2001/07 - 2004/01 Member of the Board (Conselho de Departamento) of the Department of Biochemistry Universidade de Coimbra, Portugal
Universidade de Coimbra Departamento de Bioquímica, Portugal
2001/07 - 2004/01 Member of the Executive Board of the Department of Biochemistry Universidade de Coimbra, Portugal
Universidade de Coimbra Departamento de Bioquímica, Portugal
1999 - 2001 Member of the Committee for the Self-Evaluation of the BSc in Biochemistry Universidade de Coimbra, Portugal
Universidade de Coimbra Departamento de Bioquímica, Portugal

Others

Category
Host institution
Employer
2007 - Current Researcher at an R&D unit Universidade de Coimbra, Portugal
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal
2006 - Current Researcher at an R&D unit Universidade de Coimbra, Portugal
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia, Portugal
1994 - 2006 Researcher at an R&D unit Universidade de Coimbra, Portugal
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Espectroscopia de RMN, Portugal
Projects

Grant

Designation Funders
1994/01 - 1999/10 Genetic Manipulation of Energy Metabolism in Mammalian Cells
NA
PhD Student Fellow
Junta Nacional de Investigação Científica e Tecnológica
Concluded
1994 - 1999 Genetic Manipulation of Energy Metabolism in Mammalian Cells
NA
PhD Student Fellow
Biotechnology and Biological Sciences Research Council
Concluded
1991 - 1991 Erasmus fellowship for an internship at the Delft University of Technology, Delft, Holland
NA
Other
Concluded

Contract

Designation Funders
2022/01/01 - 2023/12/31 Lifelong exercise: cancer prevention through modulation of immunometabolic pathways
CIMAGO 10/22
Principal investigator
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Ongoing
2022/01/01 - 2023/12/31 TRAP1-p66Shc interplay in the modulation of oxidative stress in lung cancer
CIMAGO 11/22
Principal investigator
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Ongoing
2021/10/01 - 2023/12/31 Organelle-targeted radiocomplexes for Auger therapy of cancer
PTDC/MED-QUI/1554/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/07 - 2023/06 A Proof of Concept for the Use of Mitochondria-Targeted Polyphenols to Treat Non-Alcoholic Fatty Liver Disease
CENTRO-01-0145-FEDER-181226
Researcher
Universidade de Coimbra, Portugal
Ongoing
2013 - 2016 The role of the heat shock response in Cr(VI)-induced carcinogenesis
CIMAGO 16/12
Principal investigator
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Concluded
2013/05 - 2015/09 Cancer stem cells and tumor progression: from molecular mechanisms to clinical consequences
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2013/01 - 2013/12 O meu primeiro contacto com a Ciência | My first contact with science
PcC170
Researcher
Ciência Viva
Concluded
2008 - 2012 The role of bioenergetics in carcinogenesis
CIMAGO 26/07
Principal investigator
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Concluded
2006 - 2009 Development of a Cellular System for the Study of Cr(VI)-Induced Lung Carcinogenesis
CIMAGO 16/06
Researcher
Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
Concluded
2004 - 2007 Cr(VI) genotoxicity
POCTI/CBO/48631/2002
Researcher
Portuguese Foundation for Science & Technology (FCT)
Concluded
2004 - 2007 Pt(II) Complexes with Biogenic Polyamines as Novel Anticancer Agents - Structure-Activity Relationships
POCTI/QUI/47256/2002
Researcher
Portuguese Foundation for Science & Technology (FCT)
Concluded
2005 - 2006 Acção Integrada Luso-Espanhola para 2005/2006
E – 3/05
Researcher
Consejo de Rectores de Universidades Privadas
Concluded
Outputs

Publications

Book chapter
  1. Abreu, P. L.; Ferreira, L. M. R.; Cunha-Oliveira, T.; Alpoim, M. C.; Urbano, A. M.. "HSP90: A Key Player in Metal-Induced Carcinogenesis?". In Heat Shock Protein 90 in Human Diseases and Disorders, 217-247. Springer International Publishing, 2019.
    Published • 10.1007/978-3-030-23158-3_11
  2. L. Abreu, Patrícia; M. Urbano, Ana. "Targeting the Warburg Effect for Cancer Therapy: A Long and Winding Road". In Frontiers in Clinical Drug Research - Anti-Cancer Agents, 271-324. BENTHAM SCIENCE PUBLISHERS, 2016.
    Published • 10.2174/9781681082899116030006
  3. M., Ana; R. Ferreira, Leonardo M.; F., Joana; F., Carlos; C., Maria. "DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy". In DNA Repair and Human Health, 177-238. InTech, 2011.
    Published • 10.5772/23190
Journal article
  1. António Jorge Guiomar; Ana M. Urbano. Corresponding author: António Jorge Guiomar. "Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review". Membranes 12 (2022): 1281.
    Open access • Published
  2. Carlos M. Soares; Ana M. Teixeira; Hugo Sarmento; Fernanda M. Silva; Marcio C. Rusenhack; Meirielly Furmann; Paulo R. Nobre; et al. "Effect of exercise-conditioned human serum on the viability of cancer cell cultures: a systematic review and meta-analysis". Exercise Immunology Review 27 (2021): 24-41.
    Open access • Published
  3. Paulo J. Oliveira; Ana M. Urbano. "Oncometabolism: The switchboard of cancer ¿ An editorial¿". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867 2 (2021): 166031-166031. http://dx.doi.org/10.1016/j.bbadis.2020.166031.
    10.1016/j.bbadis.2020.166031
  4. Ana M. Urbano. "Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867 1 (2021): 165965-165965. http://dx.doi.org/10.1016/j.bbadis.2020.165965.
    10.1016/j.bbadis.2020.165965
  5. Ana M. Urbano. "Intermediary metabolism: An intricate network at the crossroads of cell fate and function". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 10 (2020): 165887-165887. http://dx.doi.org/10.1016/j.bbadis.2020.165887.
    10.1016/j.bbadis.2020.165887
  6. Ferreira, Leonardo M. R.; Cunha-Oliveira, Teresa; Sobral, Margarida C.; Abreu, Patrícia L.; Alpoim, Maria Carmen; Urbano, Ana M.. "Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress". International Journal of Molecular Sciences 20 19 (2019): 4901. http://dx.doi.org/10.3390/ijms20194901.
    Published • 10.3390/ijms20194901
  7. Patrícia L. Abreu; Teresa Cunha-Oliveira; Leonardo M. R. Ferreira; Ana M. Urbano. "Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells". BioMetals 31 4 (2018): 477-487. https://doi.org/10.1007/s10534-018-0093-7.
    Published • 10.1007/s10534-018-0093-7
  8. Abreu, Patricia L.; Ferreira, Daniela C.; Laranjeiro, Ana F.; Mascarenhas, Alexandra; Pais, Cláudia; Melo, Joana B.; Carreira, Isabel M.; Urbano, Ana M.. "Impact of the culturing conditions and culture age on the growth characteristics and genomic stability of BEAS-2B cells". Free Radical Biology and Medicine 120 S1 (2018): S93-S93. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.307.
    10.1016/j.freeradbiomed.2018.04.307
  9. Abreu, Patrícia L.; Cunha-Oliveira, Teresa; Ferreira, Leonardo M. R.; Urbano, Ana M.. "Exposure of human bronchial epithelial cells to the lung carcinogen hexavalent chromium confers resistance to thermal shock and interferes with the stress response". European Journal of Clinical Investigation 47 SI (S1) (2018): 22-22. http://dx.doi.org/10.1007/s10534-018-0093-7.
    10.1007/s10534-018-0093-7
  10. Costa, Letícia; Silva, Joana; Fonseca, Sofia; Arranja, Cláudia; Urbano, Ana; Sobral, Abilio. "Photophysical Characterization and in Vitro Phototoxicity Evaluation of 5,10,15,20-Tetra(quinolin-2-yl)porphyrin as a Potential Sensitizer for Photodynamic Therapy". Molecules 21 4 (2016): 439. http://dx.doi.org/10.3390/molecules21040439.
    Published • 10.3390/molecules21040439
  11. Abreu, P. L.; Ferreira, L. M. R.; Alpoim, M. C.; Urbano, A. M.. "Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer". BioMetals 27 3 (2014): 409-443. http://dx.doi.org/10.1007/s10534-014-9726-7.
    Published • 10.1007/s10534-014-9726-7
  12. Cerveira, Joana F.; Sánchez-Aragó, María; Urbano, Ana M.; Cuezva, José M.. "Short-term exposure of nontumorigenic human bronchial epithelial cells to carcinogenic chromium(VI) compromises their respiratory capacity and alters their bioenergetic signature". FEBS Open Bio 4 1 (2014): 594-601. http://dx.doi.org/10.1016/j.fob.2014.06.006.
    Published • 10.1016/j.fob.2014.06.006
  13. Urbano, Ana; Ferreira, L. M. R.; Abreu, P. L.. "Exposure of human bronchial epithelial cells to hexavalent chromium [Cr(VI)] decreases the expression of heat shock protein 90 alpha (Hsp90 alpha) and attenuates the transient growth arrest induced by an acute cold shock". FEBS Journal 280 S1 (2013): SW03.S13-97-SW03.S13-97.
  14. Ana M. Urbano; M.R. Ferreira, L.; C. Alpoim, M.. "Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective". Current Drug Metabolism 13 3 (2012): 284-305. http://dx.doi.org/10.2174/138920012799320464.
    Published • 10.2174/138920012799320464
  15. Gonçalves, M.J.; Santos, A.C.C.; Rodrigues, C.F.D.; Coelho, P.; Costa, A.N.; Guiomar, A.J.; Santos, M.S.; Alpoim, M.C.; Urbano, A.M.. "Changes in glucose uptake rate and in the energy status of PC-12 cells acutely exposed to hexavalent chromium, an established human carcinogen". Toxicological and Environmental Chemistry 93 6 (2011): 1202-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960665821&partnerID=MN8TOARS.
    Published • 10.1080/02772248.2011.581340
  16. Costa, A.N.; Moreno, V.; Prieto, M.J.; Urbano, A.M.; Alpoim, M.C.. "Induction of morphological changes in BEAS-2B human bronchial epithelial cells following chronic sub-cytotoxic and mildly cytotoxic hexavalent chromium exposures". Molecular Carcinogenesis 49 6 (2010): 582-591. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953902669&partnerID=MN8TOARS.
    Published • 10.1002/mc.20624
  17. Silva, P.; Fonseca, S.M.; Arranja, C.T.; Burrows, H.D.; Urbano, A.M.; Sobral, A.J.F.N.. "A new nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)- phenyl-porphyrin as a potential sensitizer for photodynamic therapy". Photochemistry and Photobiology 86 5 (2010): 1147-1153. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956469184&partnerID=MN8TOARS.
    Published • 10.1111/j.1751-1097.2010.00764.x
  18. Gonçalves, M. J.; Santos, A.C.C.; Coelho, P.; Costa, A. N.; Rodrigues, C.F.D.; Santos, M. S.; Guiomar, A. J.; Alpoim, M. C.; Urbano, Ana. "Changes in the energy status and glucose uptake rate of PC-12 cells induced by acute subcytotoxic or mildly cytotoxic hexavalent chromium insults". FEBS Journal 277 1 (2010): 70-70.
  19. Sampaio, A.; Mendes, L.; Gonçalves, A. C.; Abrantes, M.; Sarmento, A. B.; Botelho, F.; Oliveira, P.; et al. "Malignant transformation of human bronchial epithelial cells (BEAS-2B) by Cr(VI) is associated with altered mitochondria and bioenergetic phenotype". FEBS Journal 277 S1 (2010): 70-70.
  20. Rodrigues, C.F.D.; Urbano, A.M.; Matoso, E.; Carreira, I.; Almeida, A.; Santos, P.; Botelho, F.; et al. "Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 670 1-2 (2009): 42-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350003590&partnerID=MN8TOARS.
    Published • 10.1016/j.mrfmmm.2009.07.004
  21. Rodrigues, C.F.D.; Almeida, A.; Carreira, I. M.; Matoso, E.; Urbano, Ana; Botelho. M. F.; Carvalho, L.; et al. "Hexavalent chromium and lung cancer: new perspectives". FEBS Journal 276 (2009): 339-339.
  22. Silva, M.R.; Silva, J.A.; Urbano, A.M.; Santos, A.C.; Sobral, A.J.F.N.; Beja, A.M.; Paixão, J.A.. "Crystal structure of 2,5-dimethyl-1-(4-carboxyphenyl)pyrrole, C 13H13NO2". Zeitschrift fur Kristallographie - New Crystal Structures 223 1 (2008): 33-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849085961&partnerID=MN8TOARS.
    Published • 10.1524/ncrs.2008.0016
  23. Urbano, A.M.; Rodrigues, C.F.; Alpoim, M.C.. "Hexavalent chromium exposure, genomic instability and lung cancer". Gene Therapy and Molecular Biology 12 2 (2008): 219-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350027212&partnerID=MN8TOARS.
    Published
  24. Rodrigues, C.F.D.; Urbano, Ana; Matoso, E.; Carreira, I. M.; Alpoim, M. C.. "Clastogenic effects of hexavalent chromium in a human bronchial epithelial cell line". FEBS Journal 275 1 (2008): 114-114.
  25. Soares, A.S.; Fiuza, S.M.; Gonçalves, M.J.; Batista De Carvalho, L.A.E.; Marques, M.P.M.; Urbano, A.M.. "Effect of the metal center on the antitumor activity of the analogous dinuclear spermine chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)". Letters in Drug Design and Discovery 4 7 (2007): 460-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348966192&partnerID=MN8TOARS.
    Published • 10.2174/157018007781788516
  26. Costa, A.N.; Moreno, V.; Urbano, Ana; Alpoim, M. C.. "Development of a cellular system for the study of Cr (VI)-induced lung carcinogenesis". FEBS Journal 273 1 (2006): 314-314.
  27. Costa, A. N. D.; Urbano, Ana; Moreno, V.; Morais, P. V.; Alpoim, M. C.. "Random amplification of polymorfic DNA study of Cr(VI)-induced cancer cell-like morphologic and growth characteristics on BEAS-2B cell line". Metal Ions in Biology and Medicine 9 (2006): 249-251.
  28. Costa, A. N. D.; Coelho, P. M. F.; Santos, M. S.; Paiva, A.; Urbano, Ana. "Effects of different Cr(VI) exposures on the viability and growth rates of PC 12 cultures". Metal Ions in Biology and Medicine 8 (2004): 154-157.
  29. Urbano, A.M.; Gillham, H.; Groner, Y.; Brindle, K.M.. "Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line". Biochemical Journal 352 3 (2000): 921-927. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034672358&partnerID=MN8TOARS.
    Published • 10.1042/0264-6021:3520921
  30. Geraldes, C.F.G.C.; Urbano, A.M.; Alpoim, M.C.; Sherry, A.D.; Kuan, K.-T.; Rajagopalan, R.; Maton, F.; Muller, R.N.. "Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents". Magnetic Resonance Imaging 13 3 (1995): 401-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028962910&partnerID=MN8TOARS.
    Published • 10.1016/0730-725X(94)00117-L
  31. Geraldes, Carlos F. G. C.; Delgado, Rita; Urbano, Ana M.; Costa, Judite; Jasanada, François; Nepveu, François. "Complexes of Ga3+and In3+with the N,N'-bis(butylamide) derivative of diethylenetriaminepentaacetic acid: stability constants and nuclear magnetic resonance studies in aqueous solution". J. Chem. Soc., Dalton Trans. 3 (1995): 327-335. http://dx.doi.org/10.1039/dt9950000327.
    Published • 10.1039/dt9950000327
  32. Geraldes, C.F.G.C.; Urbano, A.M.; Hoefnagel, M.A.; Peters, J.A.. "Multinuclear magnetic resonance study of the structure and dynamics of lanthanide(III) complexes of the bis(propylamide) of diethylenetriaminepentaacetic acid in aqueous solution". Inorganic Chemistry 32 11 (1993): 2426-2432. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751386808&partnerID=MN8TOARS.
    Published
  33. Alpoim, M.C.; Urbano, A.M.; Geraldes, C.F.G.C.; Peters, J.A.. "Determination of the number of inner-sphere water molecules in lanthanide(III) polyaminocarboxylate complexes". Journal of the Chemical Society, Dalton Transactions 3 (1992): 463-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049088431&partnerID=MN8TOARS.
    Published • 10.1039/DT9920000463
  34. Geraldes, C.F.G.C.; Urbano, A.M.; Alpoim, M.C.; Hoefnagel, M.A.; Peters, J.A.. "Structure and dynamics of lanthanide(III) complexes of the bis(propylamide) of diethylenetriaminepentaacetic acid in aqueous solution". Journal of the Chemical Society, Chemical Communications 9 (1991): 656-658. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049078350&partnerID=MN8TOARS.
    Published • 10.1039/C39910000656
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/03/08 Exploiting the energy metabolism for cancer diagnosis and therapy ONE HEALTH and the Metabolism-Disease-Environment Triangle: When Biomedicine Meets Innovation, Science Outreach and Social Sciences (PhD Course)
Doctoral Program in Experimental Biology and Biomedicine, University of Coimbra (Coimbra, Portugal)
2022/02/07 Biochemistry, the chemistry of life Secondary School Seminar
Escola Secundária Infanta D. Maria (Coimbra, Portugal)
2019/09 Otto Warburg, the father of oncometabolism. 2nd FEBS Advanced Course on Oncometabolism: From Conceptual Knowledge to Clinica Applications.
(Luso)
2019/06 Biochemistry, the chemistry of life Summer University
Universidade de Coimbra, Portugal
2019/03 The Warburg effect as the cornerstone of oncometabolism. Oncometabolism: Principles and Applications (PhD Course)
Doctoral Programme in Experimental Biology and Biomedicine (Coimbra, Portugal)
2018/06 Biochemistry, the chemistry of life Summer University
Universidade de Coimbra, Portugal
2018/01 Biochemistry, the chemistry of life Secondary School Seminar
Escola Básica e Secundária da Quinta das Flores, Coimbra, Portugal
2017/06 Cancer and metabolism - how it all began. FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications.
(Figueira da Foz, Portugal)
2016/11 Metabolic alterations produced by hexavalent chromium: insights into the molecular mechanisms underlying its carcinogenicity. Cancer Metabolism and the Tumour Microenvironment (Conference)
(Paphos, Cyprus)
2015/02 Targeting the Warburg effect for anticancer therapy: A long and winding road Molecular Biology of Cancer (Master Course)
Master in Cellular and Molecular Biology (Coimbra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021 - Current Organelle-targeted Radioconjugates for Auger Therapy of Cancer: Biochemical and Biological Characterization of their "Cold" Surrogates
Supervisor of Margarida Conceição Moreira Soares
Experimental Biology and Biomedicine (PhD)
Universidade de Coimbra, Portugal
2019 - Current Lifelong exercise: celular and molecular mechanisms underlying associated reduced cancer risk
Co-supervisor of Carlos Manuel da Silva Soares
Sport Sciences (PhD)
Universidade de Coimbra, Portugal
2022/09 - 2033/10 Effects of serum from elderly women conditioned by a 28-week program of aquatic exercise on the transformation of cancer lung cells
Co-supervisor
Biokinetics (Master)
Universidade de Coimbra, Portugal
2022/09 - 2033/10 Effect of exercise-conditioned sera on cultured mammalian breast cancer cells
Co-supervisor
Biokinetics (Master)
Universidade de Coimbra, Portugal
2021 - 2022 Impact of hexavalent chromium, a lung carcinogen, on the stress response of cultured human bronchial epithelial cells and on their susceptibility to stress
Supervisor of Inês de Carvalho Fresco da Rosa
Biochemistry (Master)
Universidade de Coimbra, Portugal
2021 - 2022 Organelle-targeted Radioconjugates for Auger Therapy of Cancer: Biochemical and Biological Characterization of their "Cold" Surrogates
Co-supervisor of Rafael Paulo Silveira
Cellular and Molecular Biology (Master)
Universidade de Coimbra, Portugal
2021 - 2022 TRAP1-p66Shc Interplay in the Modulation of Oxidative Stress in Lung Cancer
Co-supervisor of Catarina Mendes
Cellular and Molecular Biology
Universidade de Coimbra, Portugal
2020 - 2021 Molecular Mechanisms of Hexavalent Chromium Toxicity: An In Vitro Study
Co-supervisor of Adriana Sofia Soares Mata
Biochemistry (Master)
2019 - 2020 Effect of extended passaging in the characteristics of BEAS-2B cells, an in vitro model for lung epithelium
Supervisor of Margarida Conceição Moreira Sobral
Mestrado em Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015 - 2016 Mechanisms of hexavalent chromium carcinogenicity: Effects on the stress response and on the genomic stability of the BEAS-2B cell line
Supervisor of Patrícia Alexandra Lona Abreu
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015 Effects of Hexavalent Chromium on the Energy Metabolism of a Human Bronchial Epithelium Cell Line
Supervisor of Daniela Cravo Ferreira
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2013 Synthesis and Characterization of Porphyrins as Potential Photosensitizing Agents in Photodynamic Therapy
Co-supervisor of Letícia Daniela da Silva Costa
Mestrado em Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009 - 2011 Effect of Short-Term Cr(VI) Exposure on Energy Metabolism In Human Lung Epithelial Cells
Co-supervisor of Joana Felício Cerveira
Mestrado em Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2007 - 2008 Synthesis and Evaluation of the Cytotoxicity of New Pyrrolic Compounds with Potential Anti-HIV-1 Activity
Co-supervisor of Ana Catarina Calado Santos
Mestrado em Biologia Celular (Master)
Universidade de Coimbra Departamento de Zoologia, Portugal
2006 - 2007 Plasmid Quality Control for Use in Gene Therapy and Vaccination with DNA
Co-supervisor of Alexandra Maria Bagulho Safara Inverno
Mestrado em Engenharia Bioquímica (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2006 - 2007 Effects of hexavalent chromium on the energy metabolism
Co-supervisor of Maria João Silva Gonçalves
MSc in Cell Biology (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/09/01 - 2019/09/06 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications. Luso, Portugal, 1–6 de Setembro de 2019 (2019/09/01 - 2019/09/01)
Other (Co-organisor)
2017/06/18 - 2017/06/24 FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications. Figueira da Foz, Portugal, 18–24 de Junho de 2017 (2017/06/18 - 2017/06/24)
Other (President of the Organising Committee)
2013/01 - 2013/12 Workshop to primary school students (EB1 Solum, Coimbra) about Biochemistry, within the framework of the Ciência Viva project ""My first contact with science". (2013/01 - 2013/12)
Workshop (Co-organisor)
2010/09/26 - 2010/09/28 16th International Charles Heidelberger Symposium on Cancer Research, 26-28 September, 2010, Coimbra, Portugal (2010/09/26 - 2010/09/28)
Symposium (Co-organisor)

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2022/02/28 Silica-polymer hybrid nanosystems to mediate combined antitumor strategies
(Thesis) Arguer
Daniel Lopes Oliveira (Master)
Universidade de Coimbra, Portugal
2021/12/17 Synthesis and Characterization of a Biocompatible Fluorinated Mn(III)-Porphyrin as a Redox Responsive 19F-NMR/T1 Bimodal MRI Contrast Agent
President of the jury
Ana Rita Rolo Ferreira (Master)
Universidade de Coimbra, Portugal
2021/12/15 Molecular Mechanisms of Hexavalent Chromium Carcinogenicity: an In Vitro Study
Supervisor
Adriana Sofia Soares Mata (Master)
Universidade de Coimbra, Portugal
2020/03/03 Molecular Mechanism of Horizontal Mitochondrial Transfer From Stromal Cells To Cancer Cells With Damaged Mitochondrial DNA
(Thesis) Arguer
Ana Raquel Ligeiro Coelho (PhD)
Universidade de Coimbra, Portugal
2020/02/27 Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation: Developing new approaches for osteoporosis treatment
(Thesis) Arguer
Sara Inês Furtado Canário (Master)
Universidade de Coimbra, Portugal
2019/09/12 Influência da P-caderina na biologia mitocondrial de células de cancro da mama
(Thesis) Arguer
Margarida Ribeiro da Silva (Master)
Universidade de Coimbra, Portugal
2018/09/20 They May Be at Rest: Metabolic Regulation of Paused Pluripotency
(Thesis) Arguer
Bibiana Correia da Silva (Master)
Universidade de Coimbra, Portugal
2018/09/15 Genomic characterization of monoclonal gammopathy patients
(Thesis) Arguer
Alexandra Maria de Jesus Couto Oliveira (Master)
Universidade de Coimbra, Portugal
2016/03/15 Mechanisms of Hexavalent Chromium Carcinogenicity: Effects on the Stress Response and on the Genomic Stability of the BEAS-2B Cell Line
Supervisor
Patrícia Alexandra Lona Abreu (Master)
Universidade de Coimbra, Portugal
2015/09 Mitochondria-directed antioxidants as anticancer agents
President of the jury
Kátia Queirós Fernandes dos Santos (Master)
Universidade de Coimbra, Portugal
2015/07/24 Efeitos do Crómio Hexavalente no Metabolismo Energético de uma Linha Celular do Epitélio Brônquico Humano
Supervisor
Daniela Cravo Ferreira (Master)
Universidade de Coimbra, Portugal
2013/10/23 Insights on the Accumulation and Biosynthetic Pathway for Mannosylglucosylglycerate in the Deep-branching Phylum Planctomycetes
(Thesis) Arguer
Ana Sofia Ventura Cunha (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07/23 Vitamina C e quimioterapia: Uma potencial sinergia contra o cancro colo-retal | Vitamin C and chemotherapy: A potential synergy against colo-rectal cancer
President of the jury
Cláudia Raquel Ferreira Marques (Master)
Universidade de Coimbra, Portugal
2013/07/16 Síntese e Caracterização de Porfirinas como Potenciais Agentes Fotossensibilizadores em Terapia Fotodinâmica
Supervisor
Letícia Daniela da Silva Costa (Master)
Universidade de Coimbra, Portugal
2013/03/15 Disfunção Hepática em Animais Modelo para a Doença de Alzheimer: O Papel do Stress Oxidativo e da Beta-Amilóide
(Thesis) Main arguer
Joana Filipa Almeida Faria (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/03/27 Quimio e Radioterapia no Carcinoma Hepatocelular. Influência da p53
(Thesis) Arguer
Ana Rita Balsa Gomes (Master)
Universidade de Coimbra, Portugal
2011/09/12 The Role of Senescent Fibroblasts on Epithelial Cells Malignant Transformation
(Thesis) Main arguer
Luís André Lima da Gama Mendes (Master)
Universidade de Coimbra, Portugal
2011/07/20 Biological Activity of Chemical Compounds: Possible Chemopreventive and Synergistic Activity
(Thesis) Main arguer
Mariana Feijó Fernandes (Master)
Universidade de Coimbra, Portugal
2011/07/19 Effect of Short-Term Cr(VI) Exposure on Energy Metabolism In Human Lung Epithelial Cells
Supervisor
Joana Felício Cerveira (Master)
Universidade de Coimbra, Portugal
2010/07/22 Sobre os Mecanismos que Regem a Formação de Complexos de Inclusão Supramoleculares Host-Guest de Coclodextrinas e Espécies Anfifílicas
(Thesis) Main arguer
Hugo Aragão Correia (Master)
Universidade de Coimbra, Portugal
2010/02/01 Complexos Polinucleares de Paládio(II) como Novos Agentes Anticancerígenos: Relações Estrutura-Actividade | Polynuclear Complexes of Palladium (II) as New Anticancer Agents: Structure-Activity Relationships
(Thesis) Arguer
Sónia Martins Fiúza (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008/11/27 Síntese e Avaliação da Citotoxicidade de Novos Compostos Pirrolicos com Potencial Actividade Anti-VIH-1
Supervisor
Ana Catarina Calado Santos (Master)
Universidade de Coimbra, Portugal
2008/09/18 Sinalização Celular Mediada pelo Receptor Flt3 e Proteínas Ras como Alvos Terapêuticos no Tratamento da Síndrome Mielodisplásica
(Thesis) Main arguer
Ana Catarina Rodrigues Oliveira (Master)
2007/06 Controlo de qualidade de plasmídeos para utilização em terapia génica e vacinação com DNA
Supervisor
Alexandra Maria Bagulho Safara Inverno (Master)
Universidade de Coimbra, Portugal
1999/12 Expressão da fotoproteína aquorina derivada da medusa Aequorea victoria em células secretoras de insulina
(Thesis) Main arguer
Ana Paula Cabral Marques (Master)
Universidade de Coimbra, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/01/01 - Current Frontiers in Cell and Developmental Biology Frontiers
2021/01/01 - Current Frontiers Oncology Frontiers
2021/01/01 - Current Cancers MDPI
2020/01/01 - Current Food & Function Royal Society of Chemistry
2019/01/01 - Current Biochimica Biophysica Acta – Molecular Basis of Disease Elsevier
2019/01/01 - Current Current Drug Metabolism Bentham
2019 - Current Journal of Clinical Medicine MDPI
2017 - Current International Journal of Molecular Sciences MDPI
2016/01/01 - Current Biological Trace Element Research Springer
2016 - Current Luminescence Wiley
2015 - Current Free Radical Research Taylor & Francis
2013/01/01 - Current European Journal of Medicinal Chemistry Elsevier

Association member

Society Organization name Role
2019/11 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2012/08 - Current The European Association for Cancer Research (EACR) Member
2002 - Current Sociedade Portuguesa de Bioquímica / Portuguese Biochemical Society Member
1992 - 2009/11 Sociedade Portuguesa de Química / Portuguese Chemical Society Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/09 - Current Bioquímica Física / Physical Chemistry Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/07 - Current Bioquímica das Proteínas, Lípidos e Ácido Nucleicos Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/07 - Current Introdução ao Laboratório de Bioquímica / Introduction to the Biochemistry Laboratory Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09 - 2021/02 Bioquímica / Biochemistry Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2016/09 - 2017/07 Biomateriais / Biomaterials Bioquímica (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/09 - 2016/07 Bioquímica I / Biochemistry I Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09 - 2016/07 Laboratórios de Bioquímica I / Laboratories of Biochemistry I Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014 - 2015 Biologia Molecular do Cancro / Molecular Biology of Cancer Mestrado em Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/07 - 2014/09 Bioquímica II / Biochemistry II Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2007/09 - 2014/07 Bioquímica Física / Physical Biochemistry Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2007/09 - 2009/07 Laboratórios de Bioquímica I / Laboratories of Biochemistry I Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2003/09 - 2009/07 Bioquímica II / Biochemistry II Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Bioquímica, Portugal
2005/09 - 2007/07 Laboratórios de Bioquímica / Biochemistry Laboratories Química (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2000/09 - 2007/07 Bioquímica II / Biochemistry II Química (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2000/09 - 2007/07 Enzimologia / Enzimology Química (Especialização pós-licenciatura) Universidade de Coimbra Departamento de Química, Portugal
1997/09 - 2005/07 Bioquímica Laboratorial I / Biochemistry Laboratory I Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Bioquímica, Portugal
2000/07 - 2004/09 Biotecnologia em Diagnóstico e Terapêutica / Biotechnology in Diagnostics and Theurapeutics Mestrado em Engenharia Bioquímica / Master in Biochemical Engeneering (Mestrado) Universidade de Coimbra Departamento de Bioquímica, Portugal
1999/09 - 2002/07 Enzimologia /Enzymology Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Bioquímica, Portugal
1999/07 - 2000/09 Bioquímica Analítica / Analytical Biochemistry Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1993/07 - 1994/09 Biomateriais / Biomaterials Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1992/09 - 1994/09 Enzimologia / Enzimology Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1992/07 - 1993/09 Bioquímica I / Biochemistry I Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1989/09 - 1992/07 Química Geral / General Chemistry Biologia / Biology (Licenciatura) Universidade de Coimbra Departamento de Zoologia, Portugal
1989/09 - 1991/07 Química Inorgânica / Inorganic Chemistry Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Distinctions

Award

2014 Honorable mention at the 4th Portuguese Young Chemists Meeting (4th PYCheM), Coimbra, Portugal, for a poster entitled “Comparative in vitro studies on the photodynamic effectiveness of 5,10,15,20-tetrakis-(quinolin-2-yl)-porphyrin and (...)

Other distinction

2013 Professor of the Year (BSC in Biochemistry)
Núcleo de Estudantes de Bioquímica da Associação Académica de Coimbra, Portugal
1986 Felowship to participate in the XXVIII London International Youth Science Fortnight; London, August 1986.
Fundação Calouste Gulbenkian, Portugal