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Carlos Ezequiel Antunes Costa concluiu a Licenciatura em Bioquímica em 2013, pela Universidade do Minho - Escola de Ciências. Em 2016, concluiu o Mestrado em Biologia Molecular, Biotecnologia e Bioempreendedorismo em Plantas, pela Universidade do Minho - Escola de Ciências. Entre 2016 e 2018, participou, como investigador, no projeto internacional "YeasTempTation: Tailoring thermotolerant yeasts for more sustainable, eco-efficient and competitive industrial fermentations". Doutorado em Engenharia Química e Biológica pela Universidade do Minho, o seu projeto de doutoramento focou-se na produção de resveratrol utilizando leveduras geneticamente modificadas. Posteriormente, foi investigador júnior no âmbito do projeto ESSEntial entre 2022 e 2024, onde se especializou na engenharia genética de fungos filamentosos para a produção de lactonas por fermentação. Participou durante o seu percurso em diversas atividades de disseminação de ciência, com destaque para o Pint of Science Portugal, onde desempenhou o papel de coordenador da equipa de vídeo a nível nacional entre 2019 e 2021. Atualmente, é comunicador de ciência no Laboratório Associado LABBELS, na Universidade do Minho, onde é responsável pela produção de conteúdo e implementação da estratégia de comunicação da instituição.
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Identification

Personal identification

Full name
Carlos Ezequiel Antunes Costa

Citation names

  • Costa, Carlos E.

Author identifiers

Ciência ID
0110-B61C-9122
ORCID iD
0000-0001-6842-8511

Email addresses

  • carlos.costa@ceb.uminho.pt (Professional)

Addresses

  • CEB - Centre of Biological Engineering, University of Minho. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Industrial Biotechnology - Bioderived Bulk and Fine Chemicals

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2018/02/01 - 2022/07/26
Concluded
 Chemical and Biological Engineering (Doutoramento)
Universidade do Minho Centro de Engenharia Biológica, Portugal
"Resveratrol de novo biosynthesis from lignocellulosic biomass: metabolic engineering of thermotolerant robust yeast strains for an integrated and intensified bioprocess" (THESIS/DISSERTATION)
2014/09 - 2016/10
Concluded
 Molecular Biology, Biotechnology and Bioentrepreneurship in Plants (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"Effective bioethanol production from Plant-based biomass by genetically modified yeast strains" (THESIS/DISSERTATION)
 18
2010/09 - 2013/07
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Studies on the effect of the grapevine leafroll-associated virus 3 on the metabolism and composition of the grape berry in Cabernet Sauvignon and Touriga Nacional cultivars" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/11/21 - 2024/12/31 Contracted Researcher (Research) Universidade do Minho, Portugal
Universidade do Minho Centro de Engenharia Biológica, Portugal
2021/11/01 - 2021/12/31 Visiting Researcher (Research) Universidade de Vigo - Campus Ourense, Spain
Universidade de Vigo - Campus Ourense, Spain
2018/03/01 - 2018/06/30 Visiting Researcher (Research) Danmarks Tekniske Universitet, Denmark
DTU Biosustain - The Novo Nordisk Foundation Center for Biosustainability, Denmark

Others

Category
Host institution 		Employer
2016/11/22 - 2018/01/31 Research fellow in the international project "YeasTempTation: Tailoring thermotolerant yeasts for more sustainable, eco-efficient and competitive industrial fermentations", supervised by Professor Luc Universidade do Minho Centro de Engenharia Biológica, Portugal
2015/09/15 - 2016/10/14 Curricular internship in Industrial Biotechnology comprehended in the Master's Degree in Molecular Biology, Biotechnology and Bioentrepreneurship in Plants from University of Minho, supervised by Full Universidade do Minho Centro de Engenharia Biológica, Portugal
2013/02/01 - 2013/07/26 Curricular internship in the field of Plant Physiology comprehended in the Bachelor's degree in Biochemistry, under the supervision of Associate Professor Hernâni Gerós and António Teixeira Universidade do Minho Escola de Ciências, Portugal
Projects

Grant

Designation Funders
2018/02 - 2022/02 Resveratrol de novo biosynthesis from lignocellulosic biomass: metabolic engineering of thermotolerant robust yeast strains for an integrated and intensified bioprocess
SFRH/BD/130739/2017
 Fundação para a Ciência e a Tecnologia
2016/04 - 2018/01 YeasTempTation: Tailoring thermotolerant yeasts for more sustainable, eco-efficient and competitive industrial fermentations
CEB-BI-18-2016
 Secretaria de Estado de Ciência Tecnologia e Ensino Superior

Contract

Designation Funders
2022/11/21 - 2024/12/31 ESSEntial - Establishing sustainable bioproduction of lactones from metabolic engineering of industrial cell factory systems: Ashbya gossypii
PTDC/BII-BTI/1858/2021
Post-doc
Universidade do Minho Centro de Engenharia Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Cristiana Martins; Costa, Carlos E.; Cunha, Joana T.; Domingues, Lucília. "Harnessing Saccharomyces cerevisiae for sustainable FDCA production: optimizing 5-HMF detoxification and derivative synthesis". Paper presented in Microbiotec '23, Covilhã, 2023.
    Accepted
  2. Costa, Carlos; Francisco, Miguel; Quinta, Tatiana Q.; Domingues, Lucília. "Enhanced lactone de novo biosynthesis using recombinant Ashbya gossypii". Paper presented in PYFF8 - 8th Conference on Physiology of Yeasts and Filamentous Fungi., Cork, Ireland, 2023.
    Published
Conference paper
  1. Costa, Carlos E.; Møller-Hansen, I; Romaní, Aloia; José A. Teixeira; Irina Borodina; Domingues, Lucília. "Engineered industrial yeast for resveratrol de novo production from wine waste". Paper presented in 3rd BioIberoAmerica – Ibero-American Congress on Biotechnology, Braga, 2022.
  2. Costa, Carlos. "Metabolic engineering of robust industrial strains for de novo resveratrol production from sole carbon sources for application in process-like conditions". 2018.
Conference poster
  1. Costa, Carlos E.; Freitas, Luís; Francisco, Miguel; Aguiar, Tatiana Q.; Domingues, Lucília. "Enhancing lactone biosynthesis in Ashbya gossypii: towards sustainable production from diverse carbon sources". Paper presented in Microbiotec '23, 2023.
  2. Baptista, Marlene; Costa, Carlos E.; Domingues, Lucília. "Microbial production of the building block p-Coumaric Acid: unleashing the potential of Kluyveromyces marxianus". Paper presented in Microbiotec '23, 2023.
  3. Costa, Carlos. "Robust industrial strains as platform for de novo resveratrol production from carbon sources: establishing grounds for an integrated process". 2019.
  4. Costa, Carlos E.. "Yeast Cell factory development for biorefineries". 2018.
  5. Costa, Carlos. "Screening of thermotolerant yeast strains for more sustainable, eco-efficient and competitive industrial fermentations". 2017.
  6. Costa, Carlos E.. "Towards a cost-effective bioethanol process: yeast development to overcome challenges derived from lignocellulosic processing". 2016.
  7. Costa, Carlos. "Metabolic engineering industrial yeast strains for efficient hemicellulosic bioethanol production". 2016.
  8. Costa, Carlos. "An integrated and intensified approach for enhanced bioethanol production and validation with different lignocellulosic materials". 2016.
Journal article
  1. Arias, Ana; Costa, Carlos E.; Moreira, Maria Teresa; Feijoo, Gumersindo; Domingues, Lucília. "Resveratrol-based biorefinery models for favoring its inclusion along the market value-added chains: A critical review". Science of The Total Environment 908 (2024): 168199. http://dx.doi.org/10.1016/j.scitotenv.2023.168199.
    Published • 10.1016/j.scitotenv.2023.168199
  2. Arias, Ana; Costa, Carlos E.; Feijoo, Gumersindo; Moreira, Maria Teresa; Domingues, Lucília. "Process modeling, environmental and economic sustainability of the valorization of whey and eucalyptus residues for resveratrol biosynthesis". Waste Management 172 (2023): 226-234. http://dx.doi.org/10.1016/j.wasman.2023.10.030.
    Published • 10.1016/j.wasman.2023.10.030
  3. Arias, Ana; Costa, Carlos E.; Moreira, Maria Teresa; Feijoo, Gumersindo; Domingues, Lucília. "Environmental and techno-economic assessment on the valorization of vine-side streams to produce resveratrol". Journal of Cleaner Production 429 (2023): 139622. http://dx.doi.org/10.1016/j.jclepro.2023.139622.
    Published • 10.1016/j.jclepro.2023.139622
  4. Carlos E. Costa; Aloia Romaní; José A. Teixeira; Lucília Domingues. "Resveratrol production for the valorisation of lactose-rich wastes by engineered industrial Saccharomyces cerevisiae". Bioresource Technology 359 (2022): 127463-127463. http://dx.doi.org/10.1016/j.biortech.2022.127463.
    10.1016/j.biortech.2022.127463
  5. Carlos E. Costa; Patrícia Carvalho; Lucília Domingues. "Strategic combination of different promoters in lactose metabolisation and host chassis selection for high bioethanol titres from dairy wastes". Bioresource Technology Reports 19 (2022): 101131-101131. http://dx.doi.org/10.1016/j.biteb.2022.101131.
    10.1016/j.biteb.2022.101131
  6. Carlos E. Costa; Aloia Romaní; Iben Møller-Hansen; José A. Teixeira; Irina Borodina; Lucília Domingues. "Valorisation of wine wastes by de novo biosynthesis of resveratrol using a recombinant xylose-consuming industrial Saccharomyces cerevisiae strain". Green Chemistry (2022): https://doi.org/10.1039/D2GC02429B.
    10.1039/D2GC02429B
  7. Patrícia Carvalho; Carlos E. Costa; Sara L. Baptista; Lucília Domingues. "Yeast cell factories for sustainable whey-to-ethanol valorisation towards a circular economy". Biofuel Research Journal 8 4 (2021): 1529-1549. http://dx.doi.org/10.18331/brj2021.8.4.4.
    10.18331/brj2021.8.4.4
  8. Carlos E. Costa; Iben Møller-Hansen; Aloia Romaní; José Teixeira; Irina Borodina; Lucília Domingues. "Resveratrol Production from Hydrothermally Pretreated Eucalyptus Wood Using Recombinant Industrial Saccharomyces cerevisiae Strains". ACS Synthetic Biology 10 8 (2021): 1895-1903. http://dx.doi.org/10.1021/acssynbio.1c00120.
    10.1021/acssynbio.1c00120
  9. Baptista, Sara L.; Costa, Carlos E.; Cunha, Joana T.; Soares, Pedro O.; Domingues, Lucília. "Metabolic engineering of Saccharomyces cerevisiae for the production of top value chemicals from biorefinery carbohydrates". Biotechnology Advances 47 (2021): 107697. http://dx.doi.org/10.1016/j.biotechadv.2021.107697.
    Published • 10.1016/j.biotechadv.2021.107697
  10. Cunha, Joana T.; Soares, Pedro O.; Baptista, Sara L.; Costa, Carlos E.; Domingues, Lucília. "Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production". Bioengineered 11 1 (2020): 883-903. http://dx.doi.org/10.1080/21655979.2020.1801178.
    Published • 10.1080/21655979.2020.1801178
  11. Costa, Carlos E.. "Selection and subsequent physiological characterisation of industrial Saccharomyces cerevisiae strains during continuous growth at sub- and- supra optimal temperatures". (2020): http://dx.doi.org/10.1101/2020.01.30.926709.
    10.1101/2020.01.30.926709
  12. Costa, Carlos. "Molecular and physiological basis of Saccharomyces cerevisiae tolerance to adverse lignocellulose-based process conditions". Applied Microbiology and Biotechnology (2019): http://dx.doi.org/10.1007/s00253-018-9478-3.
    10.1007/s00253-018-9478-3
  13. Costa, Carlos. "HAA1 and PRS3 overexpression boosts yeast tolerance towards acetic acid improving xylose or glucose consumption: unravelling the underlying mechanisms". Applied Microbiology and Biotechnology (2018): http://dx.doi.org/10.1007/s00253-018-8955-z.
    10.1007/s00253-018-8955-z
  14. Costa, C.E.; Romaní, A.; Cunha, J.T.; Johansson, B.; Domingues, L.. "Integrated approach for selecting efficient Saccharomyces cerevisiae for industrial lignocellulosic fermentations: Importance of yeast chassis linked to process conditions". Bioresource Technology 227 (2017): 24-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006969461&partnerID=MN8TOARS.
    10.1016/j.biortech.2016.12.016