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Magda's educational background includes a Bachelor’s Degree in Physics (2013) and Master's in Nuclear and Particle Physics (2016), from the University of Coimbra (Portugal). Currently, Magda is doing a PhD in Physics, also at the University of Coimbra, focusing on the development and implementation of a cost-effective method to produce zirconium-89, from liquid targets, using a medical cyclotron. This work has potential to significantly impact the global supply of zirconium-89 and advance the field of immuno-PET. Notably, Magda’s work has already demonstrated successful application in a pioneering clinical trial at ICNAS. Professionally, Magda has been an integral part of ICNAS-Pharma (formerly ICNAS-Produção) since 2015. She began as a cyclotron physicist and has since assumed the role of Radiation Protection Officer, overseeing all aspects related to radioprotection within ICNAS. Additionally, Magda is an essential member of the medical physics team and has contributed significantly to various research projects and publications related to the development of new production methods for radionuclides and radiopharmaceuticals, as well as the advancement of novel PET scanner instrumentation.
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Identification

Personal identification

Full name
Magda Silva

Citation names

  • Silva, Magda
  • Silva, M.

Author identifiers

Ciência ID
0019-72BF-BFA3
ORCID iD
0000-0003-3688-8921

Email addresses

  • magdasilva@icnas.uc.pt (Professional)

Addresses

  • ICNAS, Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Websites

  • pt.linkedin.com/in/magdacarvalhosilva (Personal)

Knowledge fields

  • Exact Sciences - Physical Sciences - Nuclear Physics
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2)
French Elementary (A2) Upper intermediate (B2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2020/09 - 2024/06
Ongoing
 Doutoramento em Física (Doutoramento)
Major in Física Nuclear e de Partículas
Universidade de Coimbra, Portugal
2019/05/07 - 2019/05/09
Concluded
 Curso em Proteção Radiológica (Outros)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2013 - 2016
Concluded
 Física Nuclear e de Partículas (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Application of ICP-MS in the optimisation of a new methodology for Ga-68 production in a PET dedicated cyclotron" (THESIS/DISSERTATION)
2015/02/06 - 2015/02/20
Concluded
 Curso em "Experimental Radiobiology and Radioprotection" (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2013
Concluded
 Física (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2016/10 - Current Cyclotron physicist ICNAS-Produção, Lda, Portugal
2016/01 - Current Radiation Protection Officer ICNAS-Produção, Lda, Portugal
2015/12 - 2016/09 intern cyclotron physicist ICNAS-Produção, Lda, Portugal
Outputs

Publications

Journal article
  1. Magda Silva; Ivanna Hrynchak; Antero Abrunhosa; Francisco Alves. "Production of clinical amounts GMP compliant zirconium-89 from cyclotron liquid targets: towards global availability of 89Zr-based radiopharmaceuticals". Nuclear Medicine and Biology (2023): http://dx.doi.org/10.1016/j.nucmedbio.2023.108784.
    10.1016/j.nucmedbio.2023.108784
  2. Ivanna Hrynchak; Diana Cocioaba; Radu Leonte; Magda Silva; Maria-Roxana Cornoiu; Dana Niculae; Antero Abrunhosa. "GMP Production of Copper-64 for antibody and nanobody radiolabeling: liquid vs solid target". Nuclear Medicine and Biology (2023): http://dx.doi.org/10.1016/j.nucmedbio.2023.108728.
    10.1016/j.nucmedbio.2023.108728
  3. Paulo Fonte; Luís Lopes; Rui Alves; Nuno Carolino; Paulo Crespo; Miguel Couceiro; Orlando Cunha; et al. "An RPC-PET brain scanner demonstrator: First results". Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (2023): http://dx.doi.org/10.1016/j.nima.2023.168236.
    10.1016/j.nima.2023.168236
  4. Ivanna Hrynchak; Magda Silva; Liliana Santos; Amílcar Falcão; Célia Gomes; Antero Abrunhosa. "89Zr-immuno-PET imaging: from liquid target production to imaging". Nuclear Medicine and Biology (2022): http://dx.doi.org/10.1016/s0969-8051(22)02141-2.
    10.1016/s0969-8051(22)02141-2
  5. Alexandra I. Fonseca; Vítor Alves; Sergio JC do Carmo; Magda Silva; Ivanna Hrynchak; Francisco José Cerqueira Alves; Amílcar Falcão; Antero Abrunhosa. "Production of GMP-Compliant Clinical Amounts of Copper-61 Radiopharmaceuticals from Liquid Targets". Pharmaceuticals (2022): http://dx.doi.org/10.3390/ph15060723.
    10.3390/ph15060723
  6. Jonatan Dewulf; Ivanna Hrynchak; Alexandra Fonseca; Magda Silva; Christel Vangestel; Sérgio do Carmo; José Sereno; et al. "Bringing personalized medicine to the next level: RANKL immuno-PET imaging using [64Cu]Cu-NOTA-anti-RANKL-Fab fragments". Nuclear Medicine and Biology (2022): http://dx.doi.org/10.1016/s0969-8051(22)00385-7.
    10.1016/s0969-8051(22)00385-7
  7. Alexandra Fonseca; Vitor Alves; Sérgio do Carmo; Magda Silva; Francisco Alves; Antero Abrunhosa. "Copper-61 as an alternative to Gallium-68 for radiopharmaceutical production: feasibility study and scale-up for clinical doses". Nuclear Medicine and Biology (2022): http://dx.doi.org/10.1016/s0969-8051(22)00087-7.
    10.1016/s0969-8051(22)00087-7
  8. Teles, P.; Trincão, M.; Alves, F.; Antunes, V.; Calado, D.; Cantinho, G.; Carvalho, A.L.; et al. "Evaluation of the Portuguese population exposure to ionizing radiation due to x-ray and nuclear medicine procedures from 2013 to 2017". Radiation Physics and Chemistry 172 (2020): 108762. http://dx.doi.org/10.1016/j.radphyschem.2020.108762.
    10.1016/j.radphyschem.2020.108762
  9. Alves, F.; Alves, V. H. P.; Do Carmo, S. J. C.; Neves, A. C. B.; Silva, M.; Abrunhosa, A. J.. "Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets". Modern Physics Letters A 32 17 (2017): 1740013. http://dx.doi.org/10.1142/s0217732317400132.
    10.1142/s0217732317400132
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/05 Production of clinical amounts GMP compliant zirconium-89 from cyclotron liquid targets: towards global availability of 89Zr-based radiopharmaceuticals iSRS (International Symposium on Radiopharmaceutical Sciences) 2023
2022/11 Zirconium-89: Production and Purification Technical Workshop on the Production of Radiometals for Theranostics Using a Medical Cyclotron (IAEA)
2022 Radiation Protection at ICNAS: organisational perspective in a multi-licensed facility ERPW (European Radiation Protection Week) 2022
2015/03 "História da Proteção Radiológica: Da primeira queimadura ao dosímetro de dedo" Conferência DesCultura
Escola Superior de Tecnologia da Saúde de Coimbra

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/22 - 2021/11/24 European Radiation Protection Week 2021 European Radiation Protection Week 2021
2021/10/14 - 2021/11/03 Digital Workshop - The Future of Radiological Protection
Conference
 Digital Workshop - The Future of Radiological Protection
International Commission on Radiological Protection, Canada
2019/05/27 - 2019/05/31 3rd International Conference on Dosimetry and its Applications
Conference
 ICDA 3 - 3rd International Conference on Dosimetry and its Applications
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/05/26 - 2019/05/26 4th International BioQuaRT Workshop "From Micro- and nanodosimetry to biological effectiveness” 4th International BioQuaRT Workshop "From Micro- and nanodosimetry to biological effectiveness”
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/03/23 - 2018/03/23 Future Directions in Nuclear Sciences Applied to Health
Workshop
 Future Directions in Nuclear Sciences Applied to Health
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2017/03/31 - 2017/03/31 XXII Encontro de Medicina Nuclear do CHUC
Meeting
 XXII Encontro de Medicina Nuclear do CHUC
Centro Hospitalar e Universitário de Coimbra EPE, Portugal