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I, Rita Martins, am a PhD Student at the Life and Health Sciences Research Institute (ICVS) (University of Minho). I graduated in Biomedical Sciences by the University of Aveiro in 2021, where I developed the project “Consigo Contigo: a mobile app for suicide prevention”, which earned recognition as a semifinalist in the 12th edition of the Angelini University Award. Additionally, I did a volunteer internship at the iBiMED Genomics Facility (iBiGen) under the guidance of Dr. Gabriela Moura (University of Aveiro), where I was involved in patient sample analysis for COVID-19 detection and genotyping protocols using microarrays. In 2023, I completed my Master’s in Molecular Genetics at the University of Minho with the dissertation “The therapeutical potential of TUDCA against stress-related brain pathologies”, under the supervision of Dr. Joana Silva at ICVS. During this project, I delved into the molecular, cellular and behavioural effects of TUDCA in a mouse model of chronic stress, acquiring hands-on experience in several methodologies ranging from animal manipulation and behaviour (assessment of cognition, anxiety and depressive-like behaviours) to cellular (e.g. neuronal reconstruction, spine characterization and density, and fluorescent microscopy imaging) and molecular techniques (e.g. tissue fractionation, mRNA and protein content evaluation). I received a Travel Grant from the International Society of Neurochemistry (ISN) to present my work in a poster format at the "ISN-ESN 2023 Meeting". Additionally, in 2025, I presented a poster of my work in TUDCA as a potential treatment for Alzheimer's in the "3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics" in Porto. I am also a co-author in a poster presented at the “30th Meeting of the Hellenic Society for Neuroscience (HSfN)” and in an ongoing paper "Screening of novel ASOs against Tau protein - shifting isoforms" (Campos-Marques et al., Molecular Therapy, in preparation). I have also participated in Dr. Silva’s team as a Research Fellow in a collaborative project with the International Iberian Nanotechnology Laboratory (INL), focusing on Alzheimer's Disease markers detection in blood samples. Currently, I have been granted an FCT fellowship to start my PhD project "Local translation at the synapse: the role of cytotoxic granule-associated RNA-binding protein TIA1". Simultaneously, I am enrolled in a Bioinformatic Master’s program to refine skills relevant to my research and doctoral studies.
Identification

Personal identification

Full name
Rita Nóbrega Amaral Martins

Citation names

  • Nóbrega-Martins, Rita

Author identifiers

Ciência ID
FF1D-E7C5-D96D
ORCID iD
0000-0002-1364-6404

Email addresses

  • pg46733@alunos.uminho.pt (Professional)

Telephones

Mobile phone
  • 915948177 (Personal)

Addresses

  • Rua da Sobreira, nº107, 3740-265, Sever do Vouga, Sever do Vouga, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2023/09/01 - 2025/07/31
Ongoing
Bioinformatics (Mestrado)
Universidade do Minho, Portugal
2021/09/01 - 2024/01/28
Concluded
Molecular Genetics (Mestrado)
Universidade do Minho, Portugal
"The therapeutical potential of TUDCA against stress-related brain pathologies" (THESIS/DISSERTATION)
19
2023/04/17 - 2023/04/21
Concluded
Proteomics Approaches in Life Sciences (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
19
2022/11/14 - 2022/11/25
Concluded
Laboratory Animal Science (Outros)
Universidade do Minho Escola de Ciências da Saúde, Portugal
2018/09/01 - 2021/07/09
Concluded
Biomedical Sciences (Licenciatura)
Major in Molecular Biomedicine
Universidade de Aveiro, Portugal
16
Affiliation

Science

Category
Host institution
Employer
2024/04/06 - Current Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/01/02 - 2024/04/05 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/10 - 2020/12 Research Trainee (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
Projects

Grant

Designation Funders
2024/04/06 - 2025/01 Detection of AD markers in blood samples
2022.04850.PTDC
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Nóbrega-Martins, Rita; Cunha, Adriana; Guedes, Sofia; B. Barros-Santos; Campos-Marques, Carlos; Papadimitriou, Georgia; Maciel, Patrícia; et al. Corresponding author: Joana Margarida Silva. "The therapeutic potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2025.
  2. B. Barros-Santos; Papadimitriou, Georgia; Campos-Marques, Carlos; Nóbrega-Martins, Rita; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. Corresponding author: Joana Margarida Silva. "Therapeutic potential of mTOR inhibitor – Torisel - against stress and Alzheimer’s Disease pathologies". Paper presented in 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2025.
  3. B. Barros-Santos; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Papadimitriou, Georgia; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. Corresponding author: B. Barros-Santos. "Therapeutic potential of mTOR inhibitor – Torisel - against stress and Alzheimer’s Disease pathologies". Paper presented in ERA chairs annual meeting IMMUNOHUB & NCBIO 2024, 2024.
  4. B. Barros-Santos; Gerontidi, Dimitra ; Papadimitriou, Georgia; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. "Therapeutic potential of mTOR inhibitor for the clearance of Tau accumulation and RNA-protein granules in stress and Alzheimer’s Disease pathologies". Paper presented in ICVS Retreat 2024, 2024.
  5. Megalokonomou, A; Campos-Marques, Carlos; Godinho, B; Watts, J; Samiotaki, M; Panayotou, G; Papadimitriou, G.; et al. "Antisense oligonucleotide (ASOs) therapeutic approach against Tau-driven neuronal pathology in Alzheimer's disease brain pathology.". Paper presented in 30th Meeting of the Hellenic Society for Neuroscience (HSfN), 2023.
  6. Nóbrega-Martins, Rita; Guedes, Sofia; Udochukwu, Lucian; Santos, Beatriz; Campos-Marques, Carlos; Silva, Iara; Maciel, Patrícia; et al. "Therapeutical potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in ISN-ESN 2023 Meeting, 2023.
Journal article
  1. Campos-Marques, Carlos; Megalokonomou, Anastasia; B. Barros-Santos; Nóbrega-Martins, Rita; Godinho, Bruno; Soares-Cunha, Carina; Lee, Jonathan; Silva, JM. Corresponding author: Silva, JM. "Screening of novel ASOs against Tau protein - shifting isoforms". Molecular Therapy (2024):
    Submitted
Thesis / Dissertation
  1. "The therapeutical potential of TUDCA against stress-related brain pathologies". Master, Universidade do Minho Escola de Ciências, 2024.
Activities

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/05/01 - 2019/05/10 Statistics on Health decision making: state of the art (2019/05/10 - 2019/05/10)
Symposium (Other)
Universidade de Aveiro Departamento de Matemática, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/02/06 - 2025/02/07 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Symposium
3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2024/03/16 - 2024/03/16 Introduction to RNA-Seq data analysis
Workshop
Bioinformatic Open Days XIII Edition
Universidade do Minho Escola de Engenharia, Portugal
2024/03/14 - 2024/03/16 XIII Edition of the Bioinformatic Open Days
Conference
Bioinformatic Open Days XIII Edition
Universidade do Minho, Portugal
2024/03/11 - 2024/03/15 Brain awareness week
Festival
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/09/29 - 2023/09/29 The European Researchers' Night
Festival
2023/08/08 - 2023/08/11 ISN-ESN 2023 Meeting
Conference
ISN-ESN 2023 Meeting
International Society for Neurochemistry, Switzerland
2023/08/05 - 2023/08/06 ISN-ESN MEETING SATELLITE WORKSHOP: Astrocytic Control of Brain Circuits and Behavior
Symposium
Astrocytic Control of Brain Circuits and Behavior
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/12/15 - 2023/06/27 18 months’ mentorship from an EMBL Interdisciplinary Postdoc to expand the scientific network and explore cutting-edge life science research
Other
EIPODs inspire
EMBL Heidelberg Genomics Core Facility, Germany
2023/03/13 - 2023/03/17 Brain Awareness Week
Festival
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/02/11 - 2023/02/11 Nanoparticle Production and Characterization for Biomedical Applications
Workshop
2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2023/02/10 - 2023/02/11 Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Symposium
2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2021/12/16 - 2021/12/17 23rd EMBL PhD Symposium: The Big Picture: Zooming into Life
Symposium
23rd EMBL PhD Symposium: The Big Picture: Zooming into Life
EMBL Heidelberg Genomics Core Facility, Germany
2021/05 - 2021/06 Participation in the Collaborative Online International Learning (COIL) project “A Bioquímica e a Farmacologia de mãos dadas na investigação na área da Reprodução Humana”
Other
Collaborative Online International Learning (COIL)
Universidade de Aveiro, Portugal

Universidade Estadual Paulista Júlio de Mesquita Filho, Brazil
2020/08/04 - 2020/08/08 1st LANC-UFJF Neurosciences Symposium
Symposium
LANC-UFJF Neurosciences Symposium
Universidade Federal de Juiz de Fora, Brazil
2019/06/27 - 2019/06/27 5th Post-graduate Symposium on Biomedicine
Symposium
5th Post-graduate Symposium on Biomedicine
Universidade de Aveiro Instituto de Biomedicina, Portugal
2019/03/13 - 2019/03/16 10th Edition of the National Biomedical Sciences Conference
Conference
10th Edition of the National Biomedical Sciences Conference
Universidade de Aveiro, Portugal

Mentoring / Tutoring

Topic Student name
2024/02/01 - Current TUDCA therapeutic potencial for depression: it’s impact in different brain cell populations Adriana Cunha
2023/04 - 2023/06 Therapeutic potential of TUDCA in stress-related brain pathologies Sofia Guedes
Distinctions

Award

2023 Travel Award to attend ISN-ESN 2023 Meeting
International Society for Neurochemistry, Switzerland

Other distinction

2021 Semifinalist of the 12th edition of Angelini University Award! 2020/2021
Angelini Farmacêutica Lda, Portugal