Ana Margarida Ramos Grego (E614-A9BA-923D)

Curriculum Vitae

Ana Margarida Ramos Grego

Ana Grego (AG) graduated in Biomedical Sciences (University of Aveiro, 2021, final grade 17/20) and has a master’s degree in Cardiovascular Pathophysiology (Faculty of Medicine of the University of Porto, 2023, final grade 18/20). AG's master thesis work was devoted to the study of sex differences at the histological and molecular levels in aortic valve stenosis, during which she had the opportunity to develop skills in histology as well as molecular biology techniques, such as protein/RNA extraction, immunoblotting, and RT-qPCR. In the scope of the master thesis project, she won a very competitive award, the Grants-in-Aid of Research Award (Sigma-Chi, USA, <10% of the awardees being non-American). AG's master thesis work was presented as poster communications both in national (IJUP and UMIB summit, Porto) and international (18th YES Meeting, Porto) meetings. Also, AG's master thesis work was awarded in the 18th YES Meeting (first prize in the Molecular Biology & Physiology Poster Session). Last year, AG worked as a research fellow at the Department of Surgery and Physiology at the Faculty of Medicine of the University of Porto, in the scope of a research project - SEXDIFEND - devoted to the study of sex differences in endothelial dysfunction associated with heart failure with preserved ejection fraction. Currently, AG is working as a research technician in the project PM-HFpEF, run by the Gaia/Espinho hospital, which aims to test new biomarkers in a cohort of >500 pacemaker-implanted patients with heart failure with preserved ejection fraction. Additionally, AG's group was just awarded by the Portuguese Society of Cardiology with the João Porto Grant (20K€).

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Identificação

Identificação pessoal

Nome completo: Ana Margarida Ramos Grego

Nomes de citação

Grego, Ana

Identificadores de autor

Ciência ID: E614-A9BA-923D
ORCID iD: 0009-0009-4050-3626

Telefones

Telemóvel

913442206 (Pessoal)

Domínios de atuação

Ciências Médicas e da Saúde
Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica
Ciências Médicas e da Saúde - Medicina Clínica - Sistemas Cardíacos e Cardiovasculares
Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
Ciências Médicas e da Saúde - Medicina Básica - Patologia

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2024/12 - 2025/04 Concluído	Clinical Investigator Certificate - Level 1 (Medical sub-investigator and non-medical staff) (Outros) Universidade de Aveiro, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal	75%
2024/04 Concluído	ICH Boas Práticas Clínicas E6 (R2) (Outros) The Global Health Network, Reino Unido	100%
2021/10/18 - 2023/11/28 Concluído	Fisiopatologia Cardiovascular (Mestrado) Especialização em Biologia Molecular Universidade do Porto Faculdade de Medicina, Portugal "Sexual dimorphism in aortic valve strenosis: dissecting differences at the histological and molecular levels" (TESE/DISSERTAÇÃO)	18 in 20 values
2018/09/15 - 2021/07/09 Concluído	Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal	17 in 20 values
2020/09/01 - 2021/04/01 Frequentou	Certificate in Advanced English (Outros) Cambridge Assessment, Reino Unido	197 in 210 values - CEFR Level C1

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2025/04/02 - Atual	Investigador Contratado (Investigação)	Universidade do Porto Faculdade de Medicina, Portugal

2023/07/05 - 2024/07/05	Investigador Contratado (Investigação)	Universidade do Porto Faculdade de Medicina, Portugal

Projetos

Projeto

	Designação	Financiadores
2025/04/13 - Atual	Ramping UBIquitinomics for the design of new sex-specific Therapeutic strategies for Aortic Valve stenosis Bolsa João Porto 2024 Investigador Universidade do Porto Faculdade de Medicina, Portugal	Sociedade Portuguesa de Cardiologia Em curso
2025/04/02 - Atual	PM-HFpEF: The study of Heart Failure with Preserved Ejection Fraction in Pacemaker Patients PM-HFpEF Bolseiro de Técnico de Investigação Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/07/05 - 2024/07/05	Exploring SEX-specific DIFferences in ENDothelial (dys)function towards improved HFpEF management 2022.04344.PTDC 10.54499/2022.04344.PTDC Bolseiro de Investigação Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Em curso

Produções

Publicações

Artigo em conferência	Grego, Ana; Sousa-Mendes, Cláudia; Diana Martins; Carla Sousa; Ana Ferreira; Francisca Saraiva; Guadalupe Espadas; et al. "Dissecting sexual dimorphism in aortic valve stenosis by proteomics". Trabalho apresentado em 92nd European Atherosclerosis Society Congress, Lyon, 2024. Publicado
Artigo em revista	Grego, Ana; Sousa-Mendes, Cláudia; Martins, Diana; Sousa, Carla; Ferreira, Ana; Saraiva, Francisca ; Alves, Inês ; et al. Autor correspondente: Trindade, Fábio. "Dissecting Sexual Dimorphism in Aortic Valve Stenosis by Proteomics". Clinical Proteomics (2025): Em revisão Grego, Ana; Fonseca, Ivo; Fernandes, Cristiana; Dias-Neto, Marina; Leite-Moreira, Adelino; Oliveira, Sandra Marisa; Trindade, Fábio; Nogueira-Ferreira, Rita. Autor correspondente: Nogueira-Ferreira, Rita. "Endothelial Dysfunction in Cardiovascular Diseases: Mechanisms and In Vitro Models". Molecular and Cellular Biochemistry (2025): Aceite para publicação
Poster em conferência	Rita Nogueira-Ferreira; Joana Pinto; Cristiana Fernandes; Grego, Ana; Ivo Fonseca; Adelino Leite-Moreira; Marina Dias-Neto; Rita Ferreira; Sandra Marisa Oliveira. "The impact of 17ß-estradiol and testosterone on male and female microvascular endothelial cardiac cells (accepted for presentation)". Trabalho apresentado em ESCI 2025 Annual Scientific Meeting, 2025. Cristiana Fernandes; Grego, Ana; Ivo Fonseca; Rita Ferreira; Adelino Leite-Moreira; Marina Dias-Neto; Sandra M. Oliveira; Rita Nogueira-Ferreira. Autor correspondente: Rita Nogueira-Ferreira. "Estrogen and endothelial dysfunction: Unravelling sex differences in human cardiac microvascular endothelial cells function". Trabalho apresentado em V International Congress in Health Sciences Research, 2025. Fernandes, Cristiana; Grego, Ana; Fonseca, Ivo; Ferreira, Rita; Leite-Moreira, Adelino; Dias-Neto, Marina; Oliveira, Sandra Marisa; Nogueira-Ferreira, Rita. "Sex-dependent effects of estrogen on cardiac microvascular endothelial cell function". Trabalho apresentado em 3rd International Meeting of the Portuguese Society of Physiology, 2024. Grego, Ana; Cláudia Sousa-Mendes; Diana Martins; Carla Sousa; Ana Filipa Ferreira; Francisca Saraiva; Isabel Miranda; et al. "Sexual dimorphism in aortic valve stenosis: dissecting differences at the histological and molecular levels". Trabalho apresentado em Encontro Ciência 2024, 2024. Grego, Ana; Sousa-Mendes, Cláudia; Martins, Diana; Sousa, Carla; Ferreira, Ana Filipa; Saraiva, Francisca ; Miranda, Isabel; et al. Autor correspondente: Trindade, Fábio. "Sex Disparities in Aortic Valve Stenosis: from the histological to the molecular level". Trabalho apresentado em VII iBiMED Symposium, 2024. Fernandes, Cristiana; Oliveira, Sandra Marisa; Grego, Ana; Ferreira, Rita; Nogueira-Ferreira, Rita. "Endothelial Dysfunction in Heart Failure with Preserved Ejection Fraction: Does Sex Matter?". Trabalho apresentado em XV Biochemistry Day, 2024. Grego, Ana; Sousa-Mendes, Cláudia; Gavina, Cristina; Sousa, Carla; Leite-Moreira, Adelino; Falcão-Pires, Inês; Nogueira-Ferreira, Rita; Trindade, Fábio. "Sexual dimorphism in aortic valve stenosis: dissecting differences at the histological and molecular levels". Trabalho apresentado em UMIB Summit 2023, 2023. Grego, Ana; Sousa-Mendes, Cláudia; Gavina, Cristina; Sousa, Carla; Leite-Moreira, Adelino; Falcão-Pires, Inês; Nogueira-Ferreira, Rita; Trindade, Fábio. "Sexual dimorphism in aortic valve stenosis: dissecting differences at the histological and molecular levels". Trabalho apresentado em 18th YES - Young European Scientist - Meeting, 2023. Grego, Ana; Sousa-Mendes, Cláudia; Gavina, Cristina; Sousa, Carla; Leite-Moreira, Adelino; Falcão-Pires, Inês; Nogueira-Ferreira, Rita; Trindade, Fábio. "Study of proteins associated with sexual dimorphism in aortic valve stenosis". Trabalho apresentado em IJUP – Investigação Jovem da Universidade do Porto, 2023.
Resumo em conferência	Cristiana Fernandes; Grego, Ana; Ivo Fonseca; Rita Ferreira; Adelino Leite-Moreira; Marina Dias-Neto; Sandra Marisa Oliveira; Rita Nogueira-Ferreira. "Sex-dependent efects of estrogen on cardiac microvascular endothelial cell function". Trabalho apresentado em 3rd International Meeting of the Portuguese Physiological Society (Frontiers), Porto, 2024. Publicado
Tese / Dissertação	"Sexual dimorphism in aortic valve stenosis: dissecting differences at the histological and molecular levels". Mestrado, Universidade do Porto Faculdade de Medicina, 2023.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2025/02/25	Exploring sex-driven mechanisms in aortic valve stenosis: from histology to molecular biology	Women and Heart Health: Unpacking Sex Differences in Cardiovascular Research Faculty of Medicine, University of Porto (Portugal)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024/07/05 - 2024/07/05	Participated as a staff member representing the Faculty of Medicine of the University of Porto. Presented ongoing research activities and projects developed at the institution. (2024/07/03 - 2024/07/05) Conferência (Coorganizador)	Fundação para a Ciência e a Tecnologia, Portugal
2024/04 - 2024/04	21ª Mostra U.Porto 2024 (2024/04 - 2024/04) Exposição (Coorganizador)
2023/04 - 2023/04	20ª Mostra U.Porto 2023 (2023/04 - 2023/04) Exposição (Coorganizador)
2021/04/23 - 2021/06/23	Participation in the organization of the event "Space Talk - O Quotidiano de um Investigador na NASA" at the University of Aveiro. Member of the Department of Communication and Image (2021/06/23 - 2021/06/23)	Scientific Junior Value, Portugal
2021/04/04 - 2021/06/04	Participation in the organization of the event "Lab it up" at the University of Aveiro. Member of the Department of Communication and Image. (2021/06/04 - 2021/06/05)	Scientific Junior Value, Portugal
2021/03/08 - 2021/05/08	Participation in the organization of the event "Save a Life - Workshop de Primeiros Socorros" at the University of Aveiro. Member of the Department of Communication and Image. (2021/05/08 - 2021/05/08) Oficina (workshop) (Outra)	Scientific Junior Value, Portugal
2021/02/24 - 2021/04/24	Participation in the organization of the event "TechCare - O Futuro da Saúde" at the University of Aveiro. Member of the Department of Communication and Image. (2021/04/24 - 2021/04/24)	Scientific Junior Value, Portugal Universidade de Aveiro, Portugal
2021/01/10 - 2021/04/10	Participation in the organization of the event "Creative Branding - Creativity and Marketing Bound Together" at the University of Aveiro. Member of the Department of Communication and Image. (2021/04/10 - 2021/04/10)	Scientific Junior Value, Portugal
2020/12/10 - 2021/03/10	Participation in the organization of the event "NanoTease" at the University of Aveiro. Member of the Department of Communication and Image. (2021/03/10 - 2021/03/11)	Scientific Junior Value, Portugal Paralab, Portugal
2020/10/19 - 2020/12/19	Participation in the organization of the event "Brainload 4th Edition - Power Up Your Knowledge" at the University of Aveiro. Member of the Department of Communication and Image. (2020/12/19 - 2020/12/19)	Scientific Junior Value, Portugal
2020/10/05 - 2020/12/05	Participation in the organization of the event "Work Safe - Job Tricks and Tips" at the University of Aveiro. Member of the Department of Communication and Image. (2020/12/05 - 2020/12/05)	Scientific Junior Value, Portugal
2020/09/14 - 2020/11/14	Participation in the organization of the event "Improve Yourself" at the University of Aveiro. Member of the Department of Communication and Image. (2020/11/14 - 2020/11/14)	Scientific Junior Value, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2025/02/25 - 2025/02/25	Participated and delivered a lecture at the webinar. Seminário	Women and Heart Health: Unpacking Sex Differences in Cardiovascular Research Universidade do Porto Faculdade de Medicina, Portugal
2024/07/03 - 2024/07/05	+Ciência para uma só Saúde e Bem-estar Global Conferência	Encontro Ciência 2024 Fundação para a Ciência e a Tecnologia, Portugal
2024/05/29 - 2024/05/29	Online event about the experimental use of animal models for the study of development and regeneration. Oficina (workshop)	III Workshop em Modelos Animais - Regeneração e Desenvolvimento Universidade de Évora, Portugal
2024/04/12 - 2024/04/12	Promotion of research in the cardiovascular area in the Department of Surgery and Physiology of the Faculty of Medicine, University of Porto. Sharing concepts of cardiovascular anatomy and physiology, and histology Exposição	Mostra U.Porto 2024 Universidade do Porto, Portugal
2024/03/27 - 2024/03/27	Exploring lipidomics in the context of Health and Disease mechanisms. Oficina (workshop)	12th Workshop in Lipidomics - Lipidomics in Health and Disease Universidade de Aveiro, Portugal
2023/07/03 - 2023/07/21	Exploring soft skills and improving job skills. Oficina (workshop)	UPgrade Career Summer School Universidade do Porto, Portugal
2023/06/07 - 2023/06/07	A session about "QuantStudio Real Time PCR SmartStart Orientation - Gene Expression Application Overview", learning how to take the most out of the equipment and how to properly perform Real Time PCR analysis.	Gene Expression Application Overview Thermo Fisher Scientific Inc Pittsburgh, Estados Unidos
2023/04/22 - 2023/04/22	Promotion of research in the cardiovascular area in the Department of Surgery and Physiology of the Faculty of Medicine, University of Porto. Sharing concepts of cardiovascular anatomy and physiology, and histology Exposição	Mostra U.Porto 2023 Universidade do Porto, Portugal
2023/04/19 - 2023/04/19	The Biochemistry of Sexual Dimorphism	XIV Biochemistry Day – The sex of Biochemistry Universidade de Aveiro, Portugal
2021/07 - 2021/07	The event aimed to raise awareness about "Health Crisis Solutions – Identify, Manage, and Care". Competetion between students for the development of an innovative strategy to solve health crises (such as a pandemic situation). Participation with the project “Strategies to avoid the collapse of health units in emergency situations”.	Angelini University Award Universidade de Aveiro, Portugal Angelini Farmacêutica Lda, Portugal
2020/05 - 2021/07	Participation as organizational staff in the COVID Vaccination Center of Aveiro during the COVID-19 pandemic. Outro
2021/03/10 - 2021/03/31	Presentations and discussion about the hot topics of the neurosciences' scientific area.	Brain Gain: Discovering Neurosciences Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Sociedade Portuguesa de Neurociências, Portugal
2020/07/27 - 2020/07/31	Participation in the Summer School of IGC organized for students interested in the life sciences, from molecular and cellular biology to ecology, population genetics and mathematical modelling. Students have the opportunity to discover biological sciences as they are done in their diversity.	IGC Undergraduate Summer School Virtual Programme Instituto Gulbenkian de Ciência, Portugal
2020/05/13 - 2020/05/16	Presentation of different scientific careers and opportunities.	Scale-Up – Build Your Own Future Universidade de Aveiro, Portugal Scientific Junior Value, Portugal
2019/03/13 - 2019/03/16	Bioengineering, biotechnology, pharmacology, immunology, microbiology, neurology, and oncology. Round Table “Genetic Modification of Embryos” Conferência	X Biomedical Sciences’ National Conference Universidade de Aveiro, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2020/10/06 - 2021/06/20	Scientific Junior Value \| Junior Enterprise, Portugal	Member of the Department of Communication and Image

Distinções

Prémio

2024	Honorable Mention for the poster presentation ""Endothelial Dysfunction in Heart Failure with Preserved Ejection Fraction: Does Sex Matter?" at the XV Biochemistry Day Universidade de Aveiro, Portugal
2023	Molecular Biology and Physiology Poster Session First Prize in the 18th YES – Young European Scientist – Meeting Universidade do Porto Faculdade de Medicina, Portugal
2018	Merit Award: Scholarship to the best freshman students of the University of Aveiro Universidade de Aveiro, Portugal

Outra distinção

2023	Grant in Aid of Research Sigma Xi the Scientific Research Society, Estados Unidos