???global.info.a_carregar???
Luísa Cortes got her Ph.D in Biochemistry (2006), at the University of Coimbra, studying the involvement of pollen proteases in the initial steps of allergic response. She then moved to Prof. Ana Luísa Carvalho lab, at CNBC, as a Pos-doc fellow, studying the intracellular localization of ataxin-3, the expanded polyQ protein in Machado-Joseph Disease. Presently, Luisa Cortes is the Head of the MICC - Microscopy Imaging Center of Coimbra at the CNC (since 2007), and Principal Investigator and Coordinator of the Advanced Optical Microscopy Laboratory at the University of Coimbra. Luisa Cortes developed her scientific career collaborating with members of the UC community, and attracting her own funding. Throughout her professional career, Luísa Cortes has collaborated in several research projects by complementing the studies with biochemical and novel imaging methodologies, that can be assessed by the publication of over 30 original papers produced in co-authorship in the last years. Moreover, Luisa Cortes is committed in the dissemination of knowledge, by teaching and mentoring activities. She is a team member of the recent approved MSCA-ITN-ETN European Training Networks ¿Syn2Psy ¿ Synaptic Dysfunction in Neuropsychiatric Disorders¿, a European advanced training network in the study of cellular and molecular processes in neuropsychiatric diseases. Luisa Cortes is the "Mondego e Beiras" Polo Coordinator of the PPBI - Portuguese Platform of Bioimaging, integrated in the national Research Infrastructures roadmap, an Euro-Bioimaging and CTLS member, and a lab@Location Partner from Carl Zeiss Microscopy.
Identificação

Identificação pessoal

Nome completo
Luisa Cortes
Género
Feminino

Nomes de citação

  • Cortes, Luisa

Identificadores de autor

Ciência ID
E614-66C6-86A1
ORCID iD
0000-0001-5292-4369

Endereços de correio eletrónico

  • lcortes@cnc.uc.pt (Profissional)

Telefones

Telefone
  • 239820190 (Profissional)

Moradas

  • Center for Neurosciences and Cell Biology of Coimbra. Faculdade de Medicina, Universidade de Coimbra 1ºPiso, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • http://www.cnbc.pt/equipment/microscopyUnit.asp (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Microbiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2014 - 2014
Concluído
Trainer certification for the scientific domains: Biology, Health Sciences, Laboratory Technologies. (Curso de Especialização Tecnológica)
Ministério da Educação, Portugal
1999/10/01 - 2006/12/19
Concluído
Biochemistry (Doutoramento)
Especialização em Enzymology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Pj-peptidase, uma nova aminopeptidase N do pólen de Parietaria judaica: Efeito na integridade e na função do epitélio pulmonar" (TESE/DISSERTAÇÃO)
Approved with praise and distinction
1997/10/01 - 2000/03/09
Concluído
Biotechnology (Mestrado)
Especialização em Biochemistry Engineering
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Functional analysis of the pgmG gene from the gellan gum-producing strain Sphingomonas paucimobilis ATCC 31461, which encodes a bifunctional protein with phosphoglucomutase and phosphomannomutase activities" (TESE/DISSERTAÇÃO)
Approved
1992/10/01 - 1997/07/09
Concluído
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
15 (out of 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/10/30 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2016/10/01 - 2019/08/31 Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento
Empregador
2007/09/01 - 2019/10/30 Técnico Superior (Técnico Superior) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2014/01/01 - Atual Coordinator for the Mondego Pole of the Portuguese Platform BioImaging (PPBI) Portuguese Platform BioImaging (PPBI) - Portuguese Bioimaging Reseach Infrastructure Portugal Universidade de Coimbra, Portugal
2007/09/01 - Atual Head of the Microscopy Unit at the Center for Neuroscience and Cell Biology Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/01 - 2007/08/31 Pos-Doctoral Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/06/01 - 2006/10/01 Técnico de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/09/01 - 2004/05/01 PhD. in Biochemistry (Enzimology), with the thesis: “Pj-peptidase, uma nova aminopeptidase N do pólen de Parietaria judaica: Efeito na integridade e na função do epitélio pulmonar” Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1997 - 1999 Master in Biotechnology, with the thesis “Functional analysis of the pgmG gene from the gellan gum-producing strain Sphingomonas paucimobilis ATCC 31461, which encodes a bifunctional protein with phos Universidade de Lisboa Instituto Superior Técnico, Portugal
1992 - 1997 B.Sc. in Biochemistry Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
1994 - 1995 ERASMUS student in the Biology Department at the University of Hull, UK Universidade de Coimbra, Portugal
University of Hull, Reino Unido
Projetos

Bolsa

Designação Financiadores
2020 - 2021/07/15 TecniCOV –Desenvolvimentode testes rápidos para monitorização de anticorpos em soro e saliva
TecniCOV, número 69745
Investigador
Universidade de Coimbra, Portugal
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
2016 - 2019/12 Imaging Gene Therapy in the Brain
Provided by PTCRIS: 139557
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2015/11/30 Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission
PTDC/NEU-NMC/1098/2012
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2015/09/30 Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory
EXPL/NEU-SCC/1193/2013
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2011 - 2014/06/30 Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
PTDC/SAU-NMC/110602/2009
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/07/15 Effect of caffeine and adenosine A2A receptors on stress response: role of adrenal gland modulation
PTDC/SAU-NEU/108110/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/06/30 Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis: new targets for brain repair therapies.
PTDC/SAU-NEU/101783/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/03/31 Histamine versus antihistamines: new modulators of neurogenesis?
PTDC/SAU-NEU/104415/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2012/07/31 Mapping the metabolic and neuromodulator role of insulin in the hippocampus
PTDC/SAU-OSM/105663/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2012/06/16 Demonstrating that A2A adenosine receptors control glutamatergic synaptic plasticity through CB1 cannabinoid receptors in the striatum, thus providing attracting therapeutic targets
PTDC/SAU-NEU/100729/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2012/05/22 Pollen proteases, role in allergic disorders
PTDC/SAU-ESA/72571/2006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2012/03/31 PROFILING ATAXIN-3 UBIQUITIN PROTEASE ACTIVITY: A BIOCHEMICAL AND STRUCTURAL APPROACH
PTDC/BIA-PRO/70455/2006
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
2012 - 2012 Effect of the orexigenic peptide ghrelin on AMPA receptors levels at the synapse
EMBO Short-term fellowship - ASTF 126 2012
N/A
2005 - 2008/12/31 Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease
POCI/SAU-MMO/60156/2004
Bolseiro de Investigação
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Maia, J.; Santos, T.; Aday, S.; Agasse, F.; Cortes, L.; Malva, J.O.; Bernardino, L.; Ferreira, L.. "Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles". 2011.
Artigo em revista
  1. Luís F. Ribeiro; Tatiana Catarino; Mário Carvalho; Luísa Cortes; Sandra D. Santos; Patricio O. Opazo; Lyn Rosenbrier Ribeiro; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling (2021): https://doi.org/10.1126/scisignal.abb1953.
    10.1126/scisignal.abb1953
  2. Nepovimova, Eugenie; Svobodova, Lucie; Dolezal, Rafael; Hepnarova, Vendula; Junova, Lucie; Jun, Daniel; Korabecny, Jan; et al. "Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimers drugs dealing with cholinergic, amyloid and mitochondrial systems". Bioorganic Chemistry 107 (2021): 104596. http://dx.doi.org/10.1016/j.bioorg.2020.104596.
    10.1016/j.bioorg.2020.104596
  3. Jesus, Catarina S. H.; Soares, Helder T.; Piedade, Ana P.; Cortes, Luísa; Serpa, Carlos. "Using amyloid autofluorescence as a biomarker for lysozyme aggregation inhibition". The Analyst (2021): http://dx.doi.org/10.1039/d0an02260h.
    Aceite para publicação • 10.1039/d0an02260h
  4. Cortes, Luisa. "Pollen Proteases Play Multiple Roles in Allergic Disorders". International Journal of Molecular Sciences (2020): http://dx.doi.org/10.3390/ijms21103578.
    10.3390/ijms21103578
  5. Luísa Cortes; João Malva; Ana Cristina Rego; Cláudia F. Pereira. "Calcium Signaling in Aging and Neurodegenerative Diseases 2019". International Journal of Molecular Sciences 21 3 (2020): 1125-1125. https://doi.org/10.3390/ijms21031125.
    10.3390/ijms21031125
  6. Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells". The Journals of Gerontology: Series A (2020): http://dx.doi.org/10.1093/gerona/glz280.
    Acesso aberto • Aceite para publicação • 10.1093/gerona/glz280
  7. Daniela Batista-Almeida; Teresa Ribeiro-Rodrigues; Tânia Martins-Marques; Luisa Cortes; Manuel J. Antunes; Pedro E. Antunes; Lino Gonçalves; et al. "Ischaemia impacts TNT-mediated communication between cardiac cells". Current Research in Cell Biology 1 (2020): 100001-100001. https://doi.org/10.1016/j.crcbio.2020.04.001.
    10.1016/j.crcbio.2020.04.001
  8. Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte. "BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons". Science Signaling 12 586 (2019): eaav3577-eaav3577. https://doi.org/10.1126/scisignal.aav3577.
    10.1126/scisignal.aav3577
  9. Diana Costa; Carolina Costa; Margarida Caldeira; Luísa Cortes; João A. Queiroz; Carla Cruz. "Targeting of Cellular Organelles by Fluorescent Plasmid DNA Nanoparticles". Biomacromolecules 18 9 (2017): 2928-2936. https://doi.org/10.1021/acs.biomac.7b00877.
    10.1021/acs.biomac.7b00877
  10. Rodrigues L; Miranda IM; Andrade GM; Mota M; Cortes L; Rodrigues AG; Cunha RA; Gonçalves T. "Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly.". (2016): http://europepmc.org/abstract/med/27590517.
    10.18632/oncotarget.11760
  11. Rocha SM; Saraiva T; Cristóvão AC; Ferreira R; Santos T; Esteves M; Saraiva C; et al. "Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.". (2016): http://europepmc.org/abstract/med/27260166.
    10.1186/s12974-016-0600-0
  12. Aveleira CA; Botelho M; Carmo-Silva S; Pascoal JF; Ferreira-Marques M; Nóbrega C; Cortes L; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons.". (2015): http://europepmc.org/abstract/med/25775546.
    10.1073/pnas.1416609112
  13. Fernandes C; Anjos J; Walker LA; Silva BM; Cortes L; Mota M; Munro CA; Gow NA; Gonçalves T. "Modulation of Alternaria infectoria Cell Wall Chitin and Glucan Synthesis by Cell Wall Synthase Inhibitors.". (2014): http://europepmc.org/abstract/med/24614372.
    10.1128/AAC.02647-13
  14. Ferreira, R.; Santos, T.; Cortes, L.; Cochaud, S.; Agasse, F.; Silva, A.P.; Xapelli, S.; Malva, J.O.. "Neuropeptide y inhibits interleukin-1 beta-induced microglia motility". Journal of Neurochemistry 120 1 (2012): 93-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-83855162714&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07541.x
  15. Da¸browski, J.M.; Arnaut, L.G.; Pereira, M.M.; Urbanska, K.; Simões, S.; Stochel, G.; Cortes, L.. "Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: Evidence from intracellular fluorescence and increased photodynamic efficacy in vitro". Free Radical Biology and Medicine 52 7 (2012): 1188-1200. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857920394&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2011.12.027
  16. Ferreira, S.G.; Teixeira, F.M.; Garção, P.; Agostinho, P.; Ledent, C.; Cortes, L.; MacKie, K.; Köfalvi, A.. "Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences". Neurochemistry International 61 2 (2012): 219-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863463752&partnerID=MN8TOARS.
    10.1016/j.neuint.2012.05.009
  17. Laço, M.N.; Cortes, L.; Travis, S.M.; Paulson, H.L.; Rego, A.C.. "Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3". PLoS ONE 7 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866103154&partnerID=MN8TOARS.
    10.1371/journal.pone.0043563
  18. Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M.. "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic". Human Molecular Genetics 21 21 (2012): 4680-4702. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS.
    10.1093/hmg/dds309
  19. Santos, T.; Ferreira, R.; Maia, J.; Agasse, F.; Xapelli, S.; Cortes, L.; Bragancia, J.; et al. "Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain". ACS Nano 6 12 (2012): 10463-10474. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871596644&partnerID=MN8TOARS.
    10.1021/nn304541h
  20. Vinhas, R.; Cortes, L.; Cardoso, I.; Mendes, V.M.; Manadas, B.; Todo-Bom, A.; Pires, E.; Veríssimo, P.. "Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides". Allergy: European Journal of Allergy and Clinical Immunology 66 8 (2011): 1088-1098. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960015037&partnerID=MN8TOARS.
    10.1111/j.1398-9995.2011.02598.x
  21. De Melo Reis, R.A.; Schitine, C.S.; Köfalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G.. "Functional identification of cell phenotypes differentiating from mice retinal neurospheres using single cell calcium imaging.". Cellular and molecular neurobiology 31 6 (2011): 835-846. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856384867&partnerID=MN8TOARS.
  22. Ferreira, R.; Santos, T.; Viegas, M.; Cortes, L.; Bernardino, L.; Vieira, O.V.; Malva, J.O.. "Neuropeptide Y inhibits interleukin-1ß-induced phagocytosis by microglial cells". Journal of Neuroinflammation 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-82455168238&partnerID=MN8TOARS.
    10.1186/1742-2094-8-169
  23. Maia, J.; Santos, T.; Aday, S.; Agasse, F.; Cortes, L.; Malva, J.O.; Bernardino, L.; Ferreira, L.. "Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles". ACS Nano 5 1 (2011): 97-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955113748&partnerID=MN8TOARS.
    10.1021/nn101724r
  24. De Melo Reis, R.A.; Schitine, C.S.; Kofalvi, A.; Grade, S.; Cortes, L.; Gardino, P.F.; Malva, J.O.; de Mello, F.G.. "Functional Identification of Cell Phenotypes Differentiating from Mice Retinal Neurospheres Using Single Cell Calcium Imaging". Cellular and Molecular Neurobiology (2011): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952606231&partnerID=MN8TOARS.
    10.1007/s10571-011-9673-6
  25. Ferreira, R.; Xapelli, S.; Santos, T.; Silva, A.P.; Cristóvão, A.; Cortes, L.; Malva, J.O.. "Neuropeptide y modulation of interleukin-1ß (IL-1ß)-induced nitric oxide production in microglia". Journal of Biological Chemistry 285 53 (2010): 41921-41934. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650658398&partnerID=MN8TOARS.
    10.1074/jbc.M110.164020
  26. Grade, S.; Agasse, F.; Bernardino, L.; Silva, C.G.; Cortes, L.; Malva, J.O.. "Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin". Rejuvenation Research 13 1 (2010): 27-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949493309&partnerID=MN8TOARS.
    10.1089/rej.2009.0889
  27. Rosa, A.I.; Gonçalves, J.; Cortes, L.; Bernardino, L.; Malva, J.O.; Agasse, F.. "The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells". Journal of Neuroscience 30 13 (2010): 4573-4584. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950633340&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.5597-09.2010
  28. Macedo-Ribeiro, Sandra; Cortes, Luísa; Maciel, Patrícia; Carvalho, Ana Luísa. "Nucleocytoplasmic Shuttling Activity of Ataxin-3". PLoS ONE 4 6 (2009): e5834. http://dx.doi.org/10.1371/journal.pone.0005834.
    10.1371/journal.pone.0005834
  29. Ferro, A.; Carvalho, A.L.; Teixeira-Castro, A.; Almeida, C.; Tomé, R.J.; Cortes, L.; Rodrigues, A.-J.; et al. "NEDD8: A new ataxin-3 interactor". Biochimica et Biophysica Acta - Molecular Cell Research 1773 11 (2007): 1619-1627. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548938484&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2007.07.012
  30. Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P.. "Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides". Journal of Allergy and Clinical Immunology 118 4 (2006): 878-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS.
    10.1016/j.jaci.2006.05.029
  31. Gales, L.; Cortes, L.; Almeida, C.; Melo, C.V.; Costa, M.D.C.; Maciel, P.; Clarke, D.T.; et al. "Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: Trapping early oligomers of non-expanded ataxin-3". Journal of Molecular Biology 353 3 (2005): 642-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244434741&partnerID=MN8TOARS.
    10.1016/j.jmb.2005.08.061
  32. Videira, P.A.; Cortes, L.L.; Fialho, A.M.; Sá-Correia, I.. "Identification of the pgmG gene, encoding a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, in the gellan gum- producing strain Sphingomonas paucimobilis ATCC 31461". Applied and Environmental Microbiology 66 5 (2000): 2252-2258. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034016761&partnerID=MN8TOARS.
    10.1128/AEM.66.5.2252-2258.2000
  33. Ramalho-Santos, M.; Verissimo, P.; Cortes, L.; Samyn, B.; Beeumen, J.V.; Pires, E.; Faro, C.. "Identification and proteolytic processing of procardosin A". European Journal of Biochemistry 255 1 (1998): 133-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032127477&partnerID=MN8TOARS.
    10.1046/j.1432-1327.1998.2550133.x
Tese / Dissertação
  1. Bastos, Luísa Maria Oliveira Pinheiro Leitão Cortes. "Pj-peptidase, uma nova aminopeptidase N do pólen de Parietaria judaica : efeito na integridade e na função do epitélio pulmonar". Doutoramento, 2006. http://hdl.handle.net/10316/1772.

Outros

Outra produção
  1. Bernardino, Liliana; Eiriz, Maria Francisca; Santos, Tiago; Xapelli, Sara; Grade, Sofia; Rosa, Alexandra Isabel; Cortes, Luisa; et al. 2012. Histamine stimulates neurogenesis in the rodent subventricular zone. Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/pr. http://hdl.handle.net/10400.1/11105.
    10.1002/stem.1042
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/09/04 Fluorescence microscopy in cancer biology 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications
(Luso, Portugal)
2019/05/10 MICC Overview & Perspectives CIBB 1st Retreat “Neuroscience and Disease
(Miranda do corvo, Portugal)
2018/09/14 MICC-CNC Welcome Day @ CNC
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2018/07 First steps in Image J EMBO Practical Course: 3D developmental imaging
IGC (Oeiras, Portugal)
2018/04/10 MICC-CNC Overview Lab@location Partner Event
(Oberkochen, Alemanha)
2017/07 Laser Multiphoton Microscopy Training School on Laser Applications for Biology and Biomolecular Systems: an authentic hands-on experience.
(Coimbra, Portugal)
2016/07 First steps in Image J EMBO Practical Course: 3D developmental imaging
IGC (Oeiras, Portugal)
2016 Ataxin-3, the expanded protein in Machado-Joseph disease, has nucleocytoplasmic shuttling activity XV Congresso Nacional de Bioquímica
(Aveiro, Portugal)
2015/05/21 Light Microscopy @ UC Physics Department Seminar Series
(Coimbra, Portugal)
2015/04 Visualizing neuronal morphology and function in live cells Scientific forum «ChemBioSeasons»
(Kaliningrad, Rússia)
2015/03 CNC.IBILI – Microscopy Core Facilities CNC.IBILI Retreat
(Foz do Arelho, Portugal)
2014/07 First steps in Image J EMBO Practical Course: 3D developmental imaging
IGC (Oeiras, Portugal)
2013 Show your Research – principles of microscopy and image processing 1st reSEARCH Coimbra in Health Science
(Coimbra, Portugal)
2011 Microscopia de fluorescência aplicada XII Congresso Técnico de Anatomia Patológica
(Espinho, Portugal)
2010 Live imaging of neuro stem cells Zeiss on Your Campus
IMM (Lisboa, Portugal)
2009 Microdissecção a Laser Curso I- Patologia Molecular em Medicina
(Coimbra, Portugal)
2006 A novel aminopeptidase N from the pollen of Parietaria judaica which alters epithelial integrity and degrades neuropeptides XV Congresso Nacional de Bioquímica
(Aveiro, Portugal)
2004 Nucleocytoplasmatic shuttling activity of ataxin-3, the expanded protein in Machado-Joseph disease XIV Congresso Nacional de Bioquímica
(Vilamoura, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2017 - Atual Unraveling the role of ghrelin in cognition: effects on spine dynamics and strucutural plasticity
Coorientador
Supervision of the PhD student from the BEB PhD Programme (Doutoramento)
2015 - 2016 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
Orientador
Supervision of the Master student from the Master in Cellular and Molecular Biology. (Mestrado)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2021/01/01 - 2021/12/03 Organization of the XVII Meeting of the Portuguese Society for Neuroscience, which will be held in Coimbra, from 1 - 3 December 2021. (2021/12/01 - 2021/12/03)
Encontro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/01 - 2021/09/15 CTLS 2021 - Core Technologies for Life Sciences Meeting, is a non-profit association that brings together scientists, technical and administrative staff working in or in close association with shared resource laboratories, such as core facilities, technological platforms and research infrastructures. I was invited by the main organizer to be part of the Steering Committee of the CTLS2020 conference, and it will be a remarkable opportunity to meet a great group of Core Facilities Managers to share experiences and know-how. (2021/09/13 - 2021/09/15)
Encontro (Coorganizador)
Instituto Gulbenkian de Ciência, Portugal
2020/11 - 2020/12 2nd CNC Microscopy Image Contest. The main goal of this initiative was to disseminate the work performed by CNC researchers in social media by promoting digital interaction with society, through microscopy images. (2020/11 - 2020/12)
Exposição (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2020 1st CNC Microscopy Image Contest. Together with the Science Communication Office of CNC, we set the first CNC Microscopy Image Contest. The main goal of this initiative was to disseminate the work performed by CNC researchers in social media by promoting digital interaction with society, through microscopy images. (2019 - 2020)
Outro (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/11/06 - 2019/11/08 SPAOM 2019- Spanish and Portuguese Advanced Optical Microscopy. SPAOM is a joint effort from the Red Española de Microscopía Óptica Avanzada (REMOA) and Portuguese Platform of Biomedical Imaging (PPBI). The SPAOM aims to promote new insights in microscopy applications, developments and technologies, fostering interactions and collaborations between scientific community and industry (200 participants). (2017 - 2019)
Encontro (Membro da Comissão Organizadora)
2019/09/18 - 2019/09/20 8th Workshop of the European Calcium Society (ECS): Calcium Signaling in Aging and Neurodegenerative Diseases. The scientific program was structured into five tracks dedicated the most recent advances in understanding calcium signaling in the brain underlying aging and neurodegenerative disorders. I was involved in the organization of special sessions dedicated to technological innovations in calcium imaging followed by a hands-on session on calcium imaging methodologies. (2017 - 2019)
Encontro (Membro da Comissão Organizadora)
2019/03/20 - 2019/03/22 Tissue Clearing Workshop. Tissue clearing is a technique that enables visualization of opaque organs and tissues in 3-dimensions (3-D) by turning tissue transparent. These 3 days intensive workshop covered various topics in tissue clearing by hands-on experience, from optimization and application of various clearing techniques, to light-sheet microscopy imaging to 3D visualization and quantification. This was the first course fully dedicated to Tissue Clearing organized in Portugal (2019/03/20 - 2019/03/22)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 “MICROdia”. The MicroDay was a national initiative, on the framework of the PPBI, and where the microscopy research infrastructures from 13 nodes of PPBI open their door to under-graduated students. At CNC it was organized by MICC-CNC and involved several researchers that helped to demonstrate the importance of different light microscopy methodologies for answering their scientific questions. This event had a great impact in the regional press. (2019/05/22 - 2019/05/22)
Outro (Coorganizador)
2018 - 2018 INCOMAM2018 - 52º International Congress on Microscopy and Microanalysis. INCOMAM is the annual meeting of the Portuguese Society of Microscopy (SPM). The previous year the meeting was organized in Coimbra, by the President of the Society, and I was invited to be part of the Scientific Committee. The SPM currently encompasses the Life Science and Materials Science research fields and the main goal is to support the implementation and development of all types of microscopy and its scientific or technological applications (2018/10/12 - 2018/10/13)
Congresso (Membro da Comissão Científica)
2018 - 2018 Photography exhibition “The beauty in our cells” at Exploratório. (2018/03/13 - 2018/06)
Exposição (Coorganizador)
2012 - 2012 Advanced Fluorescence Microscopy Workshop. A 'Zeiss on Your Campus' imaging workshop, sponsored by Carl Zeiss Microscopy. The workshop provided an unique opportunity not only to learn about fluorescence microscopy techniques, but also to provide answers to users of Axiovision and ZEN Imaging software. The workshop included a combination of lectures and hands-on labs, offering the opportunity to find out which imaging technique would give the best results for individual samples, and to compare the different optical sectioning techniques. (2012/12/04 - 2012/12/06)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019 - Atual “O que são células?”. Escola Ciência Viva is a scientific education program that integrates the school curriculum in a scientific learning environment. Therefore, during my activity I introduced to 4th grade students the concept of cell and the different cell types, and students were allowed make and compared animal and vegetal cells preparations, and to visualize them under an optical microscopy.
Outro
Escola Ciência Viva
Universidade de Coimbra, Portugal
2009 - Atual Science and Technology Week
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - Atual European Research Night
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - Atual Brain Awareness Week
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2015 Super-resolution Microscopy in Infection and Immunity Symposium
Simpósio
Instituto Gulbenkian de Ciência, Portugal
2011 - 2011 Inserm workshop 210: “Emerging tools in quantitative fluorescence microscopy for systems biology” - phase I and II
Oficina (workshop)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2010/12/09 - 2010/12/12 “Euroskills” – Campeonato Europeu das Profissões. Ciência viva, Feira Internacional de Lisboa.
Exposição
2010 - 2010 Harvard Medical School Portugal workshop: “Workshop on Quantitative Light Microscopy”
Oficina (workshop)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2008/11/22 - 2008/11/23 Fórum Ciência Viva - Pavilhão Atlântico, Lisboa
Simpósio
2007 - 2007 Carl Zeiss Microimaging GmbH, Jena, Germany: Multi-Fluorescence Imaging and Quantitative Colocalization; Dynamic Live Cell Studies.
Outro
Carl Zeiss Jena GmbH, Alemanha
2005 - 2005 FENS/Hertie WINTER SCHOOL 2005: “Neurodegenerative Aggregation Disorders: From Genes to Protein Aggregation, Neuronal Disfunction and Experimental Treatments”.
Outro
Federation of European Neuroscience Societies, Bélgica
2001 - 2001 Advanced course in Classical and Molecular Genetics in Yeast
Outro
Universidade do Minho, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2016 Member of the jury of the Master thesis in Cellular and Molecular Biology of the student José Filipe Nunes Vicente
Arguente
José Filipe Nunes Vicente (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015 Member of the jury of the Master thesis in Cellular and Molecular Biology of the student Tiago Sá Campelo
Arguente
Tiago Sá Campelo (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014 Member of the jury of the Master thesis in Cellular and Molecular Biology of the student Fabio Mazza.
Arguente
Fabio Mazza (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014 Member of the jury of the PhD Thesis Project defense in PhD in Biomedical Engineering of the student Ana Baptista.
Arguente
Ana Baptista (Doutoramento)
Universidade de Coimbra Departamento de Física, Portugal
2010 Member of the jury of the PhD thesis in Neuroinflammation of the student Raquel Margarida da Silva Ferreira
Arguente
Raquel Margarida da Silva Ferreira (Doutoramento)
Universidade de Coimbra, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016 - Atual Coordinator of the Cellular and Molecular Biology course unit of the PhD Programme in Experimental Biology and Biomedicine (PDBEB). (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011 - Atual Lecture at the “Métodos e Técnicas de Investigação - Técnicas Laboratoriais” couse of the Doctoral Programme in Health Sciences. In this lecture students are introduced to Fluorescence Microscopy concepts, and the main applications in the context of Health Science research. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - Atual Lecture “Fluorescence Microscopy – Basic Concepts” at the Cellular Regulation course of the Master in Cellular and Molecular. This lecture is an introduction to Fluorescence Microscopy concepts, as wells as its application in the context of Life Science research Fluorescence Microscopy – Basic Concepts (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - Atual Coordinator of the Core Facilities course of the PhD Programme in Experimental Biology and Biomedicine (PDBEB). I am responsible for the Core Technologies at CNC course, that aims to provide an overview of the technological platforms available at CNC. This two-week compulsive introductory module focuses on the principles and high-end applications of the different methodologies and students gain a theoretical understanding and hands-on experience on state-of-the-art equipment and on data processing and analysis. Core Facilities - PDBEB Courses (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/11/09 - 2020/11/20 Advanced Imaging Methods in Neuroscience course - EIT Health Ageing PhD School (Postgraduate Certificate) Universidade de Coimbra, Portugal
2019/09/30 - 2019/10/04 Basic Concepts on Imaging Tools and Data Analysis – Syn2Psy Network School I (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09/24 - 2018/09/28 IV Quantitative Fluorescence Microscopy Course. This is a one-week intensive microscopy course (40 hours) which covers all aspects of microscopy technology, from the principles of fluorescence imaging to multidimensional imaging in fixed and living cells. The participants gain a theoretical understanding of state-of-the-art equipment used in quantitative fluorescence microscopy applied to the Cellular Biology field, as well as hands-on experience. (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 Hands-on Course on Calcium Imaging. This two-days microscopy course was dedicated to Calcium Imaging and was an invitation from the University of Beira Interior to set up the course. During the two days, participants were introduced to different calcium imaging methodologies, performed calcium imaging experiments and analysis (Especialização pós-licenciatura) Universidade da Beira Interior, Portugal
2015 - 2018 Lecturer of the “Image Analysis in Microscopy” course of the Master in Biomedical Research. In this one-week master course, I introduce to students the principles of image analysis and the use of the open source software ImageJ. I also introduce the applications of fluorescence microscopy in the context of Life Science research. Image Analysis in Microscopy (Curso de mestrado (conclusão do curso de especialização)) Universidad de Valladolid, Espanha
2017/09/18 - 2017/09/22 III Quantitative Fluorescence Microscopy Course (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/11/28 - 2016/12/02 II Quantitative Fluorescence Microscopy (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06/23 - 2016/06/24 JPND BIOMARKAPD Course: “Biological Markers in Neurological Diseases – Present and Future Approaches. In these 3 hours rotation, participants were introduced to the advantages and drawbacks of different fluorescence microscopy setups, and their application on the context of Health Science research (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/10/05 - 2015/10/09 Quantitative Fluorescence Microscopy (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2014 Hands-on Course on Microscopy Imaging Analysis (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/11/22 - 2013/11/24 I Hands-on Course on Fluorescence Microscopy and Image Analysis (Especialização pós-licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2008 - 2011 Lecturer of the Research Technologies in Neurobiology course of the Integrated Master in Biomedical Engineering. In this lecture I introduced fluorescence light microscopy and described its applications on health and live science field. (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Departamento de Física, Portugal
2009/09/02 - 2009/09/04 Course on Multifluorescence Microscopy (Especialização pós-licenciatura) Universidade de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2020 - Atual Euro-BioImaging Member of the Remote Access Working Group
2019/01 - Atual CTLS - Core Technologies for Live Sciences Co-Chair of the Training Working Group
2015/01 - Atual PPBI - Portuguese Platform for BioImaging Coordinator of the "Mondego e Beiras" Polo
2015 - Atual Carl Zeiss Partner at Microscopy Labs@location - Official signature of Microscopy Labs@location Contract between Carl Zeiss Microscopy GmbH and CNC labs@location is a community of ZEISS customers providing in depth knowledge and dedicated services. The intention is to complement the ZEISS Microscopy Customer Centers at the ZEISS production and distribution sites worldwide

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2016/03/16 - Atual PPBI - the Portuguese Platform of Bioimage is a common functional platform dedicated to promoting the technical integration and centralized management of shared resources in bioimaging. Currently, PPBI consists of 16 Nodes distributed by 3 regional poles (DOURO & MINHO, MONDEGO & BEIRAS, TEJO & ALGARVE). Luisa Cortes is the Coordinator of the Mondego & Beiras Pole of PPBI.
Outro
Portuguese Platform of Bioimaging, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2017/02/13 - 2017/05/31 Member of the Jury of the “25º Concurso para Jovens Cientistas”, Ciência Viva. Organized by Fundação da Juventude and Ciência Viva – Agência Nacional para a Cultura Cientifica e Tecnológica.

Tutoria

Tópico Nome do aluno
2017 - 2020 BRAINHEALTH 2020 – “Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias - Bolsa de gestão de ciência e tecnologia. Tatiana Andreia Forjaz Amaral Catarino
2018 - 2018 ERASMUS+ Staff Mobility for Training - Short term internship. Dane Rusçuklu
2017 - 2017 PPBI - University of Beira Interior Node - Short term internship. Ana Borges
2013 - 2015 MAIS CENTRO - "New strategies to manage brain diseases" - Post-Doctoral fellowships. Margarida Caldeira
2013 - 2015 MAIS CENTRO - "New strategies to manage brain diseases" - Post-Doctoral fellowships. Ana Isabel Ferreira Martins de Oliveira
Distinções

Outra distinção

2014 Reference Microscopy Laboratory
Carl Zeiss Mikroskopie GmbH, Alemanha
2012 University of Bordeaux EMBO Short-term fellowship - ASTF 126 – 2012
Université de Bordeaux, França
2007 Postdoctoral fellowship (SFRH/BPD/20686/2004/22)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004 Research fellowship (PRAXIS/MGI/47550/2002)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999 PhD. fellowship (PRAXIS/BD/19937/99)
Fundação para a Ciência e a Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998 Master degree fellowship (PRAXIS/BM/15058/98)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1997 Study fee fellowship as lecturer of the practical component of the General Chemistry course
Universidade de Lisboa Instituto Superior Técnico, Portugal
1994 ERASMUS fellowship