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Maria João Sousa (MJS) is a Biochemist, having obtained her undergraduate degree from the University of Porto in 1987, followed by a PhD in Biomedical Sciences, specializing in Microbiology, from the same institution in 1994. In 2011, she obtained the title of Aggregation in Biology by the University of Minho (UM). Currently, MJS serves as an Associate Professor at the University and holds the position of Director of the Biology Department (DB), which she has fulfilled for eight years. At the DB, MJS has played a pivotal role in the establishment and management of various degree programs, ranging from C1 to C3 levels. She was responsible, at DB, for the proposal of the successful Biochemistry degree (C1) and has been coordinating the curricular update and restructuring of most of the department's degree offerings, encompassing 3 C1, 4 C2, and 2 C3 programs. Throughout her career, she has served as Course Director for several programs, including the C1 degree in Applied Biology (2001-2004), the Masters in Molecular Genetics (2007-2013), and the Doctoral Program in Molecular and Environmental Biology (2018-2020). Moreover, MJS has contributed her expertise to various Course Committees and served on key academic bodies such as the Doctoral College of the University of Minho as the representative of the School of Sciences, the Scientific Council (2013-2018), Pedagogic Council (2009-2013, 2018-2020), and Management Council (2014-2018, 2021-) of the UM School of Sciences. In her research pursuits, MJS operates within the Centre for Molecular and Environmental Biology (CBMA), where she has cultivated a robust network of national and international collaborators and recruited a large number of undergraduate (23), master (45) and doctoral (21) students, of which 76 have successfully completed their work to date. Her research focuses primarily on Yeast Biology, with a specific interest in leveraging yeast biodiversity for novel biorefinery processes and enhanced food fermentations. Employing Integrative Biology approaches, she crosses findings from biochemical and physiological studies with genomic, transcriptomic, and metabolomics data to elucidate the molecular foundations of yeast behavior that can be exploited to develop fitter and better-performing yeasts. In recent years, this research has gained momentum through the TODOMICS project, which involved a comprehensive investigation into an emerging yeast species, Torulaspora delbrueckii. The findings have collectively showcased a significant diversity of phenotypes, underscoring the species' technological potential across various applications. The study has already uncovered the genetic basis for specific behaviors exhibited by certain isolates and provided a comprehensive overview of the repertoire of glucose transporters in this species, building upon team previous efforts that lead to the characterizition the only two glucose transporters previously identified in this yeast. Additionally, MJS's research extends to studying cellular and molecular responses of yeasts to environmental stresses, metabolic adaptation, and cell death pathways, to which she dedicated a significant part of her work. She also utilizes yeast as a model system to investigate heterologously expressed mammalian proteins and identify cellular targets of natural compounds and synthetic molecules, employing integrated approaches and high-throughput methodologies. MJS's scientific contributions are evident in her extensive publication record, which includes 83 peer-reviewed articles, 6 book chapters, 3 patent applications and over 260 presentations in national and international meetings. She has received 6 awards for her work, has organized 20 scientific events, and is an Editorial board member of FEMS Yeast Research and of Microbial Cell. Furthermore, as a Principal Investigator, she has led five projects and participated in an additional 26, underscoring her dedication to advancing scientific knowledge.
Identificação

Identificação pessoal

Nome completo
Maria João Marques Ferreira de Sousa Moreira

Nomes de citação

  • Sousa, Maria João

Identificadores de autor

Ciência ID
E514-D338-BBFE
ORCID iD
0000-0001-9424-4150
Scopus Author Id
7103201409

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
Produções

Publicações

Artigo em conferência
  1. Vanessa S. D. Gomes; João C. C. Ferreira; Renato E. F. Boto; Paulo Almeida; Maria João M. F. Sousa; Lucinda V. Reis; M. Sameiro T. Gonçalves. "Two Symmetrical Squarylium Cyanine Dyes: Synthesis, Photophysics and Antifungal Activity in Saccharomyces cerevisiae". 2020.
    10.3390/ecsoc-24-08423
  2. João C. C. Ferreira; Rui P. C. L. Sousa; Maria João M. F. Sousa; M. Sameiro T. Gonçalves. "Evaluation of Fluorescent Staining Capacity of Two New Nile Blue Analogues". 2020.
    10.3390/ecsoc-24-08383
  3. Leitão, Maria Inês P. S.; Raju, B. Rama; Sousa, Maria João; Coutinho, Paulo J. G.; Gonçalves, M. Sameiro T.. "Benzo[a]phenoxazinium chlorides functionalized with chloride atoms and/or ester groups". 2015.
    10.3390/ecsoc-19-a006
  4. Leitão, Maria Inês; Raju, B. Rama; Sousa, Maria João; Gonçalves, M. Sameiro T.. "Synthesis, photophysical properties and structure–activity relationship studies of novel benzo[a]phenoxazinium chlorides". 2014.
  5. Leitão, Maria Inês; Raju, B. Rama; Sousa, Maria João; Gonçalves, M. Sameiro T.. "Antiproliferative Activity of 2,3,6,7-Tetrahydro-1H-benzo[a]quinolizino[1,9-hi]phenoxazin-14(5H)-iminium Chloride Derivatives". 2014.
    10.3390/ecsoc-18-b027
  6. Leitão, Maria Inês; Raju, B. Rama; Cruz, Marco Gabriel Novais; Sousa, Maria João; Gonçalves, M. Sameiro T.. "Synthesis and study of antiproliferative activity of novel derivatives of benzo[a]phenoxazine". 2013.
  7. Santos, Júlia; Sousa, Maria João; Leão, Cecília. "Ammonium blocks chronological lifespan extension of extreme calorie restriction in amino acid-starved yeast cells associated to Tpk1- and Tor1-dependent necrotic cell death induction". 2011.
  8. Santos, Júlia; Sousa, Maria João; Leão, Cecília. "Ammonium is toxic for amino acid-starved yeast cells under extreme calorie restriction, inducing cell death through the regulation of PKA, TOR and Sch9 activities". 2011.
  9. Maciel, Vitória; Pacheco, Andreia; Simões, José Tomás; Roseira, Margarida; Sousa, Maria João. "Phenotypic and genotypic characterization of yeasts isolated in Douro wine region". 2011.
  10. Pacheco, Andreia; Almeida, M. J.; Hernandez-Lopez, Maria José; Prieto, J. A.; Randez-Gil, Francisca; Sousa, Maria João; Leão, Cecília; Araújo, Cecília Alves. "Molecular and biochemical characterization of glucose transport in Torulaspora delbrueckii". 2004.
Artigo em revista
  1. Mendes, Filipa; Miranda, Eduarda; Amaral, Leslie; Carvalho, Carla; Castro, Bruno B.; Sousa, Maria João; Chaves, Susana R.. "Novel yeast-based biosensor for environmental monitoring of tebuconazole". Applied Microbiology and Biotechnology 108 1 (2024): http://dx.doi.org/10.1007/s00253-023-12944-z.
    10.1007/s00253-023-12944-z
  2. Donzella, Lorena; Sousa, Maria João; Morrissey, John P.. "Evolution and functional diversification of yeast sugar transporters". Essays in Biochemistry (2023): http://dx.doi.org/10.1042/ebc20220233.
    10.1042/ebc20220233
  3. Ticiana Fernandes; Carolina Osório; Maria João Sousa; Ricardo Franco-Duarte. "Contributions of Adaptive Laboratory Evolution towards the Enhancement of the Biotechnological Potential of Non-Conventional Yeast Species". Journal of Fungi 9 (2023): 186.
    Acesso aberto • 10.3390/jof9020186
  4. Vanessa S. D. Gomes; João C. C. Ferreira; Renato E. Boto; Paulo Almeida; José R. Fernandes; Maria João Sousa; Lucinda V. Reis; M. Sameiro T. Gonçalves. "Evaluation of Antifungal Activity and Potential Application as Fluorescent Probes of Indolenine and Benzo[ e ] Indole-Based Squarylium Dyes". Photochemistry and Photobiology (2023):
    10.1111/php.13762
  5. João C. C. Ferreira; Sara Granja; Ana F. Almeida; Fátima Baltazar; M. Sameiro T. Gonçalves; Ana Preto; Maria João Sousa. "Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[a]phenoxazine Derivative". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010614.
    10.3390/ijms24010614
  6. Luís Ferraz; Karola Vorauer-Uhl; Michael Sauer; Maria J. Sousa; Paola Branduardi. "Impact of ergosterol content on acetic and lactic acids toxicity to Saccharomyces cerevisiae". Yeast (2022): https://doi.org/10.1002/yea.3828.
    10.1002/yea.3828
  7. Vanessa S. D. Gomes; João C. C. Ferreira; Renato E. F. Boto; Paulo Almeida; Jose R. Fernandes; Maria João Sousa; M. Sameiro T. Gonçalves; Lucinda V. Reis. "Squaraine Dyes Derived from Indolenine and Benzo[ e ]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents". Photochemistry and Photobiology (2022): https://doi.org/10.1111/php.13624.
    10.1111/php.13624
  8. Anabela Ferreira; Flávia Pereira; Celso Reis; Maria José Oliveira; Maria João Sousa; Ana Preto. "Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications". Cells (2022): https://doi.org/10.3390/cells11142183.
    10.3390/cells11142183
  9. Flávia Silva-Sousa; Ticiana Fernandes; Fábio Pereira; Diana Rodrigues; Teresa Rito; Carole Camarasa; Ricardo Franco-Duarte; Maria João Sousa. "Torulaspora delbrueckii Phenotypic and Metabolic Profiling towards Its Biotechnological Exploitation". Journal of Fungi (2022): https://doi.org/10.3390/jof8060569.
    10.3390/jof8060569
  10. Margarida Silva; Ana Pontes; Ricardo Franco-Duarte; Pedro Soares; José Paulo Sampaio; Maria João Sousa; Patrícia H. Brito. "A glimpse at an early stage of microbe domestication revealed in the variable genome of Torulaspora delbrueckii, an emergent industrial yeast". Molecular Ecology (2022):
    Acesso aberto • 10.22541/au.163250208.83761439/v1
  11. Pereira, Flávia; Ferreira, Anabela; Reis, Celso Albuquerque; Sousa, Maria João; Oliveira, Maria José; Preto, Ana. "KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications". Cells 11 3 (2022): 398. http://dx.doi.org/10.3390/cells11030398.
    10.3390/cells11030398
  12. Terra-Matos, Joana; Teixeira, Marta Oliveira; Santos-Pereira, Cátia; Noronha, Henrique; Domingues, Lucília; Sieiro, Carmen; Gerós, Hernâni; et al. "Saccharomyces cerevisiae Cells Lacking the Zinc Vacuolar Transporter Zrt3 Display Improved Ethanol Productivity in Lignocellulosic Hydrolysates". Journal of Fungi 8 1 (2022): 78. http://dx.doi.org/10.3390/jof8010078.
    10.3390/jof8010078
  13. Franco-Duarte, Ricardo; Cadež, Neža; Rito, Teresa; Drumonde-Neves, João; Dominguez, Yazmid Reyes; Pais, Célia; Sousa, Maria João; Soares, Pedro. "Whole-Genome Sequencing and Annotation of the Yeast Clavispora santaluciae Reveals Important Insights about Its Adaptation to the Vineyard Environment". Journal of Fungi 8 1 (2022): 52. http://dx.doi.org/10.3390/jof8010052.
    10.3390/jof8010052
  14. Guedes, J.P.; Baptista, V.; Santos-Pereira, C.; Sousa, M.J.; Manon, S.; Chaves, S.R.; Côrte-Real, M.. "Acetic acid triggers cytochrome c release in yeast heterologously expressing human Bax". Apoptosis 27 5-6 (2022): 368-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127552051&partnerID=MN8TOARS.
    10.1007/s10495-022-01717-0
  15. Ferreira, João Carlos Canossa; Lopes, Carla; Preto, Ana; Gonçalves, Maria Sameiro Torres; Sousa, Maria João. "Novel Nile Blue Analogue Stains Yeast Vacuolar Membrane, Endoplasmic Reticulum, and Lipid Droplets, Inducing Cell Death through Vacuole Membrane Permeabilization". Journal of Fungi 7 11 (2021): 971. http://dx.doi.org/10.3390/jof7110971.
    10.3390/jof7110971
  16. Ferraz, Luís; Sauer, Michael; Sousa, Maria João; Branduardi, Paola. "The Plasma Membrane at the Cornerstone Between Flexibility and Adaptability: Implications for Saccharomyces cerevisiae as a Cell Factory". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.715891.
    10.3389/fmicb.2021.715891
  17. Ana M.O. Azevedo; André G. Vilaranda; Ana F.D.C. Neves; Maria João Sousa; João L.M. Santos; M. Lúcia M.F.S. Saraiva. "Development of an automated yeast-based spectrophotometric method for toxicity screening: Application to ionic liquids, GUMBOS, and deep eutectic solvents". Chemosphere (2021): 130227-130227. https://doi.org/10.1016/j.chemosphere.2021.130227.
    10.1016/j.chemosphere.2021.130227
  18. Fernandes, Ticiana; Silva-Sousa, Flávia; Pereira, Fábio; Rito, Teresa; Soares, Pedro; Franco-Duarte, Ricardo; Sousa, Maria João. "Biotechnological Importance of Torulaspora delbrueckii: From the Obscurity to the Spotlight". Journal of Fungi 7 9 (2021): 712. http://dx.doi.org/10.3390/jof7090712.
    10.3390/jof7090712
  19. Chaves, Susana R.; Rego, António; Martins, Vítor M.; Santos-Pereira, Cátia; Sousa, Maria João; Côrte-Real, Manuela. "Regulation of Cell Death Induced by Acetic Acid in Yeasts". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.642375.
    10.3389/fcell.2021.642375
  20. Donzella, Lorena; Varela, Javier A; Sousa, Maria João; Morrissey, John P. "Identification of novel pentose transporters in Kluyveromyces marxianus using a new screening platform". FEMS Yeast Research 21 4 (2021): http://dx.doi.org/10.1093/femsyr/foab026.
    10.1093/femsyr/foab026
  21. Santiago, Carolina; Rito, Teresa; Vieira, Daniel; Fernandes, Ticiana; Pais, Célia; Sousa, Maria João; Soares, Pedro; Franco-Duarte, Ricardo. "Improvement of Torulaspora delbrueckii Genome Annotation: Towards the Exploitation of Genomic Features of a Biotechnologically Relevant Yeast". Journal of Fungi 7 4 (2021): 287. http://dx.doi.org/10.3390/jof7040287.
    10.3390/jof7040287
  22. Sousa, Rui P. C. L.; Ferreira, João C. C.; Sousa, Maria João; T Gonçalves, M Sameiro Sameiro T. "N-(5-Amino-9H-benzo[a]phenoxazin-9-ylidene)propan-1-aminium chlorides as antifungal agents and NIR fluorescence probes". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj00879j.
    10.1039/d1nj00879j
  23. Amaral, Leslie; Mendes, Filipa; Côrte-Real, Manuela; Sousa, Maria João; Chaves, Susana Rodrigues. "Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process". Oxidative Medicine and Cellular Longevity 2020 (2020): 1-8. http://dx.doi.org/10.1155/2020/4971525.
    10.1155/2020/4971525
  24. Leitão, Maria Inês P.S.; Rama Raju, B.; Cerqueira, Nuno M.F.S.A.; Sousa, Maria João; Gonçalves, M. Sameiro T.. "Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes". Bioorganic Chemistry 98 (2020): 103730. http://dx.doi.org/10.1016/j.bioorg.2020.103730.
    Publicado • 10.1016/j.bioorg.2020.103730
  25. Raju, B. Rama; Leitão, Maria Inês P.S.; Sousa, Maria João; Coutinho, Paulo J.G.; Gonçalves, M. Sameiro T.. "New NIR dyes based on quinolizino[1,9-hi]phenoxazin-6-iminium chlorides: synthesis, photophysics and antifungal activity". Dyes and Pigments 173 (2020): 107870. http://dx.doi.org/10.1016/j.dyepig.2019.107870.
    10.1016/j.dyepig.2019.107870
  26. Pacheco, Andreia; Donzella, Lorena; Hernandez-Lopez, Maria Jose; Almeida, Maria Judite; Prieto, Jose Antonio; Randez-Gil, Francisca; Morrissey, John P; Sousa, Maria João. "Hexose transport in Torulaspora delbrueckii: identification of Igt1, a new dual-affinity transporter". FEMS Yeast Research 20 1 (2020): http://dx.doi.org/10.1093/femsyr/foaa004.
    Publicado • 10.1093/femsyr/foaa004
  27. Vítor M. Martins; Tânia R. Fernandes; Diana Lopes; Catarina B. Afonso; Maria R.M. Domingues; Manuela Côrte-Real; Maria J. Sousa. "Contacts in Death: The Role of the ER–Mitochondria Axis in Acetic Acid-Induced Apoptosis in Yeast". Journal of Molecular Biology 431 2 (2019): 273-288. https://doi.org/10.1016/j.jmb.2018.11.002.
    10.1016/j.jmb.2018.11.002
  28. Ana Rita Costa; Nuno Machado; António Rego; Maria João Sousa; Manuela Côrte-Real; Susana R. Chaves. "Proteasome inhibition prevents cell death induced by the chemotherapeutic agent cisplatin downstream of DNA damage". DNA Repair 73 (2019): 28-33. https://doi.org/10.1016/j.dnarep.2018.10.006.
    10.1016/j.dnarep.2018.10.006
  29. Bettencourt AP; Castro M; Silva JP; Fernandes F; Coutinho OP; Sousa MJ; Proenca MF; Areias FM. "Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship.". Medicinal chemistry (Shariqah (United Arab Emirates)) (2018): http://europepmc.org/abstract/med/30295192.
    10.2174/1573406414666181005143431
  30. Bettencourt A; Castro M; Silva J; Fernandes F; Coutinho O; Sousa MJ; Proença MF; Areias F. "New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure¿Activity Relationship.". Molecules (Basel, Switzerland) (2018): http://europepmc.org/abstract/med/30282927.
    10.3390/molecules23102530
  31. Cazzanelli G; Pereira F; Alves S; Francisco R; Azevedo L; Dias Carvalho P; Almeida A; et al. "The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.". Cells (2018): http://europepmc.org/abstract/med/29463063.
    10.3390/cells7020014
  32. Inês Mendes; Isabelle Sanchez; Ricardo Franco-Duarte; Carole Camarasa; Dorit Schuller; Sylvie Dequin; Maria João Sousa. "Integrating transcriptomics and metabolomics for the analysis of the aroma profiles of Saccharomyces cerevisiae strains from diverse origins". BMC Genomics (2017):
    10.1186/s12864-017-3816-1
  33. Trindade D; Pereira C; Chaves SR; Manon S; Côrte-Real M; Sousa MJ. "VDAC regulates AAC-mediated apoptosis and cytochrome c release in yeast.". Microbial cell (Graz, Austria) (2016): http://europepmc.org/abstract/med/28357318.
    10.15698/mic2016.10.533
  34. Leitão, M. Inês P.S.; Raju, B. Rama; Naik, Sarala; Coutinho, Paulo J.G.; Sousa, Maria João; Gonçalves, M. Sameiro T.. "Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents". Tetrahedron Letters 57 35 (2016): 3936-3941. http://dx.doi.org/10.1016/j.tetlet.2016.07.065.
    10.1016/j.tetlet.2016.07.065
  35. Santos J; Leitão-Correia F; Sousa MJ; Leão C. "Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae.". Oncotarget (2016): http://europepmc.org/abstract/med/27072582.
    10.18632/oncotarget.8656
  36. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    10.1080/15548627.2015.1100356
  37. Júlia Santos; Fernanda Leitão-Correia; Maria João Sousa; Cecília Leão. "Dietary Restriction and Nutrient Balance in Aging". Oxidative Medicine and Cellular Longevity 2016 (2016): 1-10. http://dx.doi.org/10.1155/2016/4010357.
    10.1155/2016/4010357
  38. Simonyan L; Renault TT; Novais MJ; Sousa MJ; Côrte-Real M; Camougrand N; Gonzalez C; Manon S. "Regulation of Bax/mitochondria interaction by AKT.". FEBS letters (2015): http://europepmc.org/abstract/med/26763134.
    10.1002/1873-3468.12030
  39. Alves S; Castro L; Fernandes MS; Francisco R; Castro P; Priault M; Chaves SR; et al. "Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.". Oncotarget (2015): http://europepmc.org/abstract/med/26418750.
    10.18632/oncotarget.5021
  40. Santos, J.; Leitão-Correia, F.; Sousa, M.J.; Leão, C.. "Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium". Oncotarget 6 9 (2015): 6511-6523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927130073&partnerID=MN8TOARS.
  41. Rego A; Duarte AM; Azevedo F; Sousa MJ; Côrte-Real M; Chaves SR. "Cell wall dynamics modulate acetic acid-induced apoptotic cell death of Saccharomyces cerevisiae.". Microbial cell (Graz, Austria) (2014): http://europepmc.org/abstract/med/28357256.
    10.15698/mic2014.09.164
  42. Rego, A.; Trindade, D.; Chaves, S.R.; Manon, S.; Costa, V.; Sousa, M.J.; Côrte-Real, M.. "Corrigendum to The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids [FEMS Yeast Res 14, 160-178]". FEMS Yeast Research 14 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84908495171&partnerID=MN8TOARS.
    10.1111/1567-1364.12191
  43. Ferreira, P.; Cardoso, T.; Ferreira, F.; Fernandes-Ferreira, M.; Piper, P.; Sousa, M.J.. "Mentha piperita essential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage". FEMS Yeast Research (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84906377152&partnerID=MN8TOARS.
    10.1111/1567-1364.12189
  44. Mira, N.P.; Münsterkötter, M.; Dias-Valada, F.; Santos, J.; Palma, M.; Roque, F.C.; Guerreiro, J.F.; et al. "The genome sequence of the highly acetic acid-tolerant zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant". DNA Research 21 3 (2014): 299-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902996763&partnerID=MN8TOARS.
    10.1093/dnares/dst058
  45. Rego, A.; Trindade, D.; Chaves, S.R.; Manon, S.; Costa, V.; Sousa, M.J.; Côrte-Real, M.. "The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids". FEMS Yeast Research 14 1 (2014): 160-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893817418&partnerID=MN8TOARS.
    10.1111/1567-1364.12096
  46. Sousa, M.; Duarte, A.M.; Fernandes, T.R.; Chaves, S.R.; Pacheco, A.; Leão, C.; Côrte-Real, M.; Sousa, M.J.. "Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84888241538&partnerID=MN8TOARS.
    10.1186/1471-2164-14-838
  47. Santos, J.; Leão, C.; Sousa, M.J.. "Ammonium-dependent shortening of CLS in yeast cells starved for essential amino acids is determined by the specific amino acid deprived, through different signaling pathways". Oxidative Medicine and Cellular Longevity (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884262911&partnerID=MN8TOARS.
    10.1155/2013/161986
  48. Pereira, H.; Azevedo, F.; Rego, A.; Sousa, M.J.; Chaves, S.R.; Côrte-Real, M.. "The protective role of yeast Cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p)". FEBS Letters 587 2 (2013): 200-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872104913&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.11.025
  49. Pacheco, A.; Azevedo, F.; Rego, A.; Santos, J.; Chaves, S.R.; Côrte-Real, M.; Sousa, M.J.. "C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner.". PloS one 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901733243&partnerID=MN8TOARS.
  50. Rego, A.; Costa, M.; Chaves, S.R.; Matmati, N.; Pereira, H.; Sousa, M.J.; Moradas-Ferreira, P.; et al. "Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism". PLoS ONE 7 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870718175&partnerID=MN8TOARS.
    10.1371/journal.pone.0048571
  51. Rodrigues, F.; Sousa, M.J.; Ludovico, P.; Santos, H.; Côrte-Real, M.; Leão, C.. "The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii". PLoS ONE 7 12 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84871689348&partnerID=MN8TOARS.
    10.1371/journal.pone.0052402
  52. Santos, J.; Sousa, M.J.; Leão, C.. "Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan.". PloS one 7 5 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866143379&partnerID=MN8TOARS.
    10.1371/journal.pone.0037090
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    10.1155/2012/680304
  54. Sousa, M.J.; Azevedo, F.; Pedras, A.; Marques, C.; Coutinho, O.P.; Preto, A.; Gerós, H.; Chaves, S.R.; Côrte-Real, M.. "Vacuole-mitochondrial cross-talk during apoptosis in yeast: A model for understanding lysosome-mitochondria-mediated apoptosis in mammals". Biochemical Society Transactions 39 5 (2011): 1533-1537. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053351702&partnerID=MN8TOARS.
    10.1042/BST0391533
  55. Vilela-Moura, A.; Schuller, D.; Mendes-Faia, A.; Silva, R.D.; Chaves, S.R.; Sousa, M.J.; Côrte-Real, M.. "The impact of acetate metabolism on yeast fermentative performance and wine quality: Reduction of volatile acidity of grape musts and wines". Applied Microbiology and Biotechnology 89 2 (2011): 271-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651067361&partnerID=MN8TOARS.
    10.1007/s00253-010-2898-3
  56. Pereira, C.; Chaves, S.; Alves, S.; Salin, B.; Camougrand, N.; Manon, S.; Sousa, M.J.; Côrte-Real, M.. "Mitochondrial degradation in acetic acid-induced yeast apoptosis: The role of Pep4 and the ADP/ATP carrier". Molecular Microbiology 76 6 (2010): 1398-1410. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953492945&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2010.07122.x
  57. Pacheco, A.; Almeida, M.J.; Sousa, M.J.. "Improved gene disruption method for Torulaspora delbrueckii". FEMS Yeast Research 9 1 (2009): 158-160. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149345722&partnerID=MN8TOARS.
    10.1111/j.1567-1364.2008.00452.x
  58. Pacheco, A.; Pereira, C.; Almeida, M.J.; Sousa, M.J.. "Small heat-shock protein Hsp12 contributes to yeast tolerance to freezing stress". Microbiology 155 6 (2009): 2021-2028. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650739079&partnerID=MN8TOARS.
    10.1099/mic.0.025981-0
  59. Santos, J.; Sousa, M.J.; Cardoso, H.; Inácio, J.; Silva, S.; Spencer-Martins, I.; Leão, C.. "Ethanol tolerance of sugar transport, and the rectification of stuck wine fermentations". Microbiology 154 2 (2008): 422-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749186689&partnerID=MN8TOARS.
    10.1099/mic.0.2007/011445-0
  60. Pereira, C.; Silva, R.D.; Saraiva, L.; Johansson, B.; Sousa, M.J.; Côrte-Real, M.. "Mitochondria-dependent apoptosis in yeast". Biochimica et Biophysica Acta - Molecular Cell Research 1783 7 (2008): 1286-1302. http://www.scopus.com/inward/record.url?eid=2-s2.0-45049085090&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.03.010
  61. Frade, V.H.J.; Sousa, M.J.; Moura, J.C.V.P.; Gonçalves, M.S.T.. "Synthesis of naphtho[2,3-a]phenoxazinium chlorides: Structure-activity relationships of these heterocycles and benzo[a]phenoxazinium chlorides as new antimicrobials". Bioorganic and Medicinal Chemistry 16 6 (2008): 3274-3282. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949137821&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.12.013
  62. Frade, V.H.J.; Sousa, M.J.; Moura, J.C.V.P.; Gonçalves, M.S.T.. "Synthesis, characterisation and antimicrobial activity of new benzo[a]phenoxazine based fluorophores". Tetrahedron Letters 48 47 (2007): 8347-8352. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348931041&partnerID=MN8TOARS.
    10.1016/j.tetlet.2007.09.108
  63. Pereira, C.; Camougrand, N.; Manon, S.; Sousa, M.J.; Côrte-Real, M.. "ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis". Molecular Microbiology 66 3 (2007): 571-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448982828&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2007.05926.x
  64. Alves-Araújo, C.; Pacheco, A.; Almeida, M.J.; Spencer-Martins, I.; Leão, C.; Sousa, M.J.. "Sugar utilization patterns and respiro-fermentative metabolism in the baker's yeast Torulaspora delbrueckii". Microbiology 153 3 (2007): 898-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947390990&partnerID=MN8TOARS.
    10.1099/mic.0.2006/003475-0
  65. Conde, C.; Silva, Paulo; Fontes, N.; Dias, Alberto Carlos Pires; Tavares, R. M.; Sousa, Maria João; Agasse, A.; et al. "Biochemical changes throughout grape berry development and fruit and wine quality". Food 1 1 (2007): 1-22. http://hdl.handle.net/1822/6820.
  66. Guaragnella, N.; Pereira, C.; Sousa, M.J.; Antonacci, L.; Passarella, S.; Côrte-Real, M.; Marra, E.; Giannattasio, S.. "YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity". FEBS Letters 580 30 (2006): 6880-6884. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845408268&partnerID=MN8TOARS.
    10.1016/j.febslet.2006.11.050
  67. Alves-Araújo, C.; Hernandez-Lopez, M.J.; Prieto, J.A.; Randez-Gil, F.; Sousa, M.J.. "Isolation and characterization of the LGT1 gene encoding a low-affinity glucose transporter from Torulaspora delbrueckii". Yeast 22 3 (2005): 165-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-14544297381&partnerID=MN8TOARS.
    10.1002/yea.1192
  68. Alves-Araújo, C.; Hernandez-Lopez, M.J.; Sousa, M.J.; Prieto, J.A.; Randez-Gil, F.. "Cloning and characterization of the MAL11 gene encoding a high-affinity maltose transporter from Torulaspora delbrueckii". FEMS Yeast Research 4 4-5 (2004): 467-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742287054&partnerID=MN8TOARS.
    10.1016/S1567-1356(03)00208-3
  69. Alves-Araújo, C.; Almeida, M.J.; Sousa, M.J.; Leão, C.. "Freeze tolerance of the yeast Torulaspora delbrueckii: Cellular and biochemical basis". FEMS Microbiology Letters 240 1 (2004): 7-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-7044235829&partnerID=MN8TOARS.
    10.1016/j.femsle.2004.09.008
  70. Rodrigues, F.; Zeeman, A.-M.; Cardoso, H.; Sousa, M.J.; Steensma, H.Y.; Côrte-Real, M.; Leão, C.. "Isolation of an acetyl-CoA synthetase gene (ZbACS2) from Zygosaccharomyces bailii". Yeast 21 4 (2004): 325-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842525036&partnerID=MN8TOARS.
    10.1002/yea.1081
  71. Rodrigues, F.; Ludovico, P.; Sousa, M.J.; Steensma, H.Y.; Côrte-Real, M.; Leão, C.. "The spoilage yeast Zygosaccharomyces bailii forms mitotic spores: A screening method for haploidization". Applied and Environmental Microbiology 69 1 (2003): 649-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347927254&partnerID=MN8TOARS.
    10.1128/AEM.69.1.649-653.2003
  72. Araújo, C.; Sousa, M.J.; Ferreira, M.F.; Leão, C.. "Activity of essential oils from Mediterranean Lamiaceae species against food spoilage yeasts". Journal of Food Protection 66 4 (2003): 625-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037389869&partnerID=MN8TOARS.
  73. Ludovico, P.; Sousa, M.J.; Silva, M.T.; Leão, C.; Côrte-Real, M.; Ludovico P; Sousa MJ; et al. "Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid". Microbiology 147 9 (2001): 2409-2415. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034807841&partnerID=MN8TOARS.
    10.1099/00221287-147-9-2409
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    10.1016/S1567-1356(01)00006-X
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Capítulo de livro
  1. Pacheco, A.; Santos, J.; Chaves, S.; Almeida J.; Leão, C.; Sousa, Maria João. "The emerging role of the Torulaspora delbrueckii in bread and wine production: Using genetic manipulation to study molecular basis of physiological responses". In Structure and Function of Food Engineering. InTech, 2012.
    10.5772/46024
  2. Sousa, Maria João; Ludovico, P.; Rodrigues, F.; Leo, C.; Crte-Real, M.. "Stress and Cell Death in Yeast Induced by Acetic Acid". In Cell Metabolism - Cell Homeostasis and Stress Response. InTech, 2012.
    10.5772/27726
  3. Sousa, Maria João; Rodrigues, F.; Côrte-Real, M.; Leão, C.. "Transporte transmembranar". In Biologia Celular e Molecular. Lisboa, Portugal: Lidel Edições Técnicas, 2012.
    Publicado
  4. Ferreira, F.C.R.; Santos-Cruz, B.M.P.L.; Araújo, C.; Nunes, C.; Cunha, A.; Sousa, Maria João; Leão, C.; Fernandes-Ferreira, M.. "Melissa officinalis: phytochemical, bioactivity and biotechnological aspects". In Advances in Medicinal and Aromatic Plant Research, editado por Devarajan Thangadurai D.; Fernandes-Ferreira M.. Regency Publications, New Delhi; Bioscience Publications, India; and ABD Publishers, Jaipur, 2008.
    Publicado
  5. Rodrigues, F.; Sousa, Maria João; Côrte-Real, M.; Leão, C.; Rodrigues, Fernando; Joäo Sousa, Maria; Corte-Real, Manuela; Leäo, Cecília. "Zygosaccharomyces bailii: an yeast with a peculiar pattern for the regulation of acetic acid metabolism in the presence of glucose". In Non-conventional Yeasts in Genetics, Biochemistry, and Biotechnology Practical Protocols, 403-410. Springer Lab Manual, 2003.
    Publicado • 10.1007/978-3-642-55758-3_65
  6. Fortuna, M.; Sousa, Maria João; Salvador, A.; Sansonetty, F.; Côrte-Real, M.; Leão, C.; Sousa, M.J.; Côrte-Real, M.. "Cell cycle analysis of Yeasts". In Current Protocols in Cytometry (Unit 11.13). John Wiley & Sons, Inc., 2000.
    Publicado
Distinções

Prémio

2021 Microbiology Society Poster Prize in the ICY15 meets ICYGMB30 (International Congress on Yeast and International Conference of Yeast Genetics and Molecular Biology) held online on the 23-27 of August 2021.
Microbiology Society, Reino Unido
2021 FEMS Yeast Research Prize – area of yeast fundamental research, no ICY15 meets ICYGMB30 (International Congress on Yeast and International Conference of Yeast Genetics and Molecular Biology) held online on the 23-27 of August 2021
2014 Prémio de melhor apresentação em poster (ex aequo) nas XX JORNADAS DE BIOLOGIA DE LEVEDURAS “PROFESSOR NICOLAU VAN UDEN”, Lisboa, Julho de 2014
2005 Prémio Lidel atribuído a Poster, Micro’05-Biotec’05 Congress, Póvoa de Varzim, Portugal
2004 Prémio Five - Projecto FreezYeast - Concurso de Ideias de Negócio Five
Agência Nacional de Inovação SA, Portugal
2000 Outstanding Student Poster Award, XX ISAC Congress, Montpellier, France.