Filomena José Pereira da Silva Grilo da Silva (D112-1890-AD44)

Curriculum Vitae

Filomena José Pereira da Silva Grilo da Silva

Filomena Silva completed her Biochemistry Degree "Licenciatura" from the University of Beira Interior (UBI), in 2006. In 2014 Filomena completed her PhD in Health Sciences and Technologies, specialty in Biochemistry from the Faculty of Pharmacy, Universidade de Coimbra. During her PhD, Filomena Silva centralized her activity in Toxicology and Clinical Biochemistry fields, with emphasis on the characterization of pharmacological and toxicological mechanisms of action of anti-inflammatory and cytostatic molecules. Filomena was dedicated to the study of new therapeutic associations with potential application for treatment of skin inflammatory diseases or for the chemoprevention of cancer, in order to increase the clinical efficiency and to reduce side effects of these molecules, individually. In her first post-doctoral period (2014-2015) in Centre of Agronomic and Agro-Industrial Biotechnology of Alentejo (CEBAL, Portugal) Filomena was focused on the study of biological activity of natural compounds on different cancer cell models. From 2015 until now, FS is part of the Mitochondrial Toxicology and Experimental Therapeutics (MitoXT) group at Center for Neuroscience and Cell Biology (CNC). In her first year in this group (2015-2016), FS investigated the modulation of mitochondrial oxidative stress by targeted antioxidant compounds. From 2017 until now, her interests include the role of mitochondrial dysfunctions and oxidative stress mechanisms in the progression of SOD1-fALS. During this time, FS has been dedicated to study differences in metabolic phenotype between lymphoblasts from ALS patients with and without SOD1 mutations, to discern mutant-SOD1 effects on mitochondrial function. Since May 2018, FS is a principal investigator of the project entitled: “Mito4ALS - Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype” funded by Portuguese Foundation for Science and Technology.

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Identificação

Identificação pessoal

Nome completo: Filomena José Pereira da Silva Grilo da Silva

Nomes de citação

Silva, Filomena S.G.

Identificadores de autor

Ciência ID: D112-1890-AD44
ORCID iD: 0000-0001-7143-8905
Researcher Id: J-8041-2016

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Português	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2017/05/01 - 2019/08/11 Concluído	Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype (Pós-doutoramento) Fundação para a Ciência e a Tecnologia, Portugal
2019/01 - 2019/04 Concluído	Postgraduate Course on Animal Experimentation (Pós-Graduação) Especialização em Researcher/Coordinator accreditation - FELASA C category, DGAV, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Approved
2015/12/01 - 2016/07/31 Concluído	Modulation of mitochondrial oxidative stress by targeted antioxidant compounds (Pós-doutoramento) Centro de Neurociências e Biologia Celular, Portugal
2014/06/01 - 2015/09/30 Concluído	Study of the biological activity of Eucalyptus spp. Bark Extracts rich in triterpenic acids on different cancer cell models (Pós-doutoramento) Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo, Portugal
2007/10/01 - 2014/02/21 Concluído	PhD in Health Sciences and Technologies, specialty in Biochemistry (Doutoramento) Universidade de Coimbra, Portugal "“Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA”" (TESE/DISSERTAÇÃO)	Praise and Distinction
2008 - 2008 Concluído	Postgraduate course in Biomedical Data Analysis with SPSS support program (Pós-Graduação) Universidade Nova de Lisboa, Portugal	19/20
2001 - 2006 Concluído	Graduation in Biochemistry (Licenciatura) Universidade da Beira Interior, Portugal ""Separation of plasmid DNA isoforms by pseudo-affinity chromatography with ligands L-histidine"" (TESE/DISSERTAÇÃO)	17/20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/08/12 - 2021/04/30	Investigador Contratado (Investigação)	CNC.IBILI, Portugal

2017/05/01 - 2019/08/11	Pós-doutorado (Investigação)	CNC.IBILI, Portugal

2015/12/01 - 2016/07/31	Pós-doutorado (Investigação)	CNC.IBILI, Portugal

2014/06/01 - 2015/09/30	Pós-doutorado (Investigação)	Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo, Portugal

Projetos

Bolsa

	Designação	Financiadores
2018/05/01 - 2021/04/30	Development of Novel Mitochondria-Targeted Agents for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype PTDC/MED-FAR/29391/2017 Investigador responsável CNC.IBILI, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017/05/05 - 2019/08/11	Postdoctoral fellowship SFRH/BPD/122648/2016 Bolseiro de Pós-Doutoramento CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia, I.P Em curso
2014/06 - 2015/09	NEucBark – New valorization strategies for Eucalyptus spp. Bark Extracts (PTDC/AGR-FOR/3187/2012) GRANT_NUMBER: PTDC/AGR-FOR/3187/2012	Fundação para a Ciência e a Tecnologia
2007/10/01 - 2011/09/30	Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA SFRH/BD/37684/2007 Bolseiro de Doutoramento Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Teresa Cunha-Oliveira; Liliana Montezinho; Catarina Mendes; Omidreza Firuzi; Luciano Saso; Paulo J. Oliveira; Filomena S. G. Silva; Jos L. Quiles. "Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention". Oxidative Medicine and Cellular Longevity 2020 (2020): 1-29. https://doi.org/10.1155/2020/5021694. 10.1155/2020/5021694 Silva, Filomena. "Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts.". Biochimica et biophysica acta (2017): http://europepmc.org/abstract/med/28760703. 10.1016/j.bbadis.2017.07.030 Silva, Filomena S. G.; Oliveira, Paulo J.; Duarte, Maria F.. "Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?". Journal of Agricultural and Food Chemistry 64 15 (2016): 2991-3008. Publicado • 10.1021/acs.jafc.5b06021 Silva, Filomena S. G.; Simoes, Rui F.; Couto, Renata; Oliveira, Paulo J.. "Targeting Mitochondria in Cardiovascular Diseases". Current Pharmaceutical Design 22 37 (2016): 5698-5717. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388519800006&KeyUID=WOS:000388519800006. 10.2174/1381612822666160822150243 Silva, Filomena. "Determination of Cell Mass and Viability Using a Dual Sulforhodamine B/resazurin Assay.". Curr Protoc Toxicol. (2016): 10.1002/cptx.1 Silva FS; Ribeiro MP; Santos MS; Rocha-Pereira P; Santos-Silva A; Custódio JB. "Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: Potential mechanisms of hepatotoxicity". Toxicology 306 -- (2013): 93-100. Publicado • 10.1016/j.tox.2013.01.020 Silva FS; Oliveira H; Moreiras A; Fernandes JC; Bronze-da-Rocha E; Figueiredo A; Custódio JB; Rocha-Pereira P; Santos-Silva A. "Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 753 1 (2013): 42-47. Publicado • 10.1016/j.mrgentox.2012.12.017 Ribeiro MP; Silva FS; Paixão J; Santos AE; Custódio JB. "The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells". European Journal of Pharmacology 715 -- (2013): 354-362. Publicado • 10.1016/j.ejphar.2013.04.038 Silva FS; Ribeiro MP; Santos MS; Rocha-Pereira P; Santos-Silva A; Custódio JB. "The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen". Journal of Bioenergetics and Biomembranes -- (2013): 383-396. Publicado • 10.1007/s10863-013-9517-9 Ribeiro MP; Silva FS; Santos AE; Santos MS; Custódio JB. "The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency". Toxicology and Applied Pharmacology 267 1 (2013): 104-112. Publicado • 10.1016/j.taap.2012.12.012 Silva, F.S.G.; Oliveira, H.; Moreiras, A.; Fernandes, J.C.; Bronze-da-Rocha, E.; Figueiredo, A.; Custódio, J.B.A.; Rocha-Pereira, P.; Santos-Silva, A.. "The in vitro and in vivo genotoxicity of isotretinoin assessed by cytokinesis blocked micronucleus assay and comet assay". Toxicology in Vitro 27 2 (2013): 900-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873165561&partnerID=MN8TOARS. 10.1016/j.tiv.2013.01.002 Silva, Filomena. "The essential oils component p-cymene induces proton leak through Fo-ATP synthase and uncoupling of mitochondrial respiration". Journal of Experimental Pharmacology (2011): http://www.dovepress.com/the-essential-oils-component-p-cymene-induces-proton-leak-through-fo-a-peer-reviewed-article-JEP. http://dx.doi.org/10.2147/JEP.S16387
Capítulo de livro	Silva, Filomena S. G.; Costa, Cláudio F.; Marques, Ricardo J.; Oliveira, Paulo J.; Pereira, Gonçalo C.. "Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection". In Mitochondrial Biology and Experimental Therapeutics, editado por Oliveira, Paulo J., 423-490. NewYork: Springer International Publishing, 2018. Publicado • 10.1007/978-3-319-73344-9_20 Silva, F; Guerra, A; Duarte, M; Soares, B; Freire, S; Silvestre, A; Calçada, C; Pereira-Wilson, C; Lima, C. "New valorization strategies for Eucalyptus spp: bark extracts". In WASTES 2015 – Solutions, Treatments and Opportunities, 311-316. London: Taylor & Francis Group, 2015. Publicado • 10.1201/b18853-52
Poster em conferência	Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Débora, Mena; Sardão, Vilma; Duarte, Ana I.; Oliveira, Paulo J (E41F-4FB7-5948). "Unraveling glycolic pathways on amyotrophic lateral sclerosis patients presenting mutant SOD1 or unknown mutations.". Trabalho apresentado em AD/PD 2021: 15th International Conference on Alzheimer‘s & Parkinson‘s Diseases, 2021. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Silva, Daniela F.; Segura, Luís; Rosenstock, Tatiana; Oliveira, Paulo J (E41F-4FB7-5948). "Oxidant/antioxidant imbalance in lymphoblasts from amyotrophic lateral sclerosis patients with SOD1 mutations and unknown mutations.". Trabalho apresentado em 11th Targeting Mitochondria 2020 Workshop & Congress, Virtual Meeting, 2020. Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Oliveira, Paulo J (E41F-4FB7-5948); Silva, Filomena S.G.. "Exploratory analysis of mitochondrial metabolism in lymphoblasts from Amyotrophic Lateral Sclerosis patients to reveal discriminant biomarkers.". Trabalho apresentado em 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Oliveira, Paulo J (E41F-4FB7-5948). "Glycolytic fluxes and metabolic profiles distinguish amyotrophic lateral sclerosis patients from healthy controls.". Trabalho apresentado em 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020. Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Silva, Filomena S.G.; Pinho, Sónia A; Costa, Cláudio F.; Miranda-Santos, I.; Oliveira, Paulo J (E41F-4FB7-5948). "Mitochondria as biosensors for disease staging and therapeutic response.". Trabalho apresentado em 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020. Soares, Pedro; Silva, Catia; Silva, Filomena S.G.; Batie, Michael; Oliveira, Catarina; Cagide, Fernando; Oliveira, Paulo J (E41F-4FB7-5948); Rocha, Sonia; Borges, Fernanda. "Mitochondriotropic antioxidants as novel therapeutics for ALS: development of multitarget agents to prevent stress induced MN death.". Trabalho apresentado em MuTaLig COST ACTION CA15135, 5th WG meeting, 2020. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Bento, Guida; Lourenço, Nuno; Oliveira, Paulo J (E41F-4FB7-5948). "Data mining analysis of respiratory and glycolytic rates from amyotrophic lateral sclerosis patients: unravelling the effect of SOD1 mutation.". Trabalho apresentado em 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. Cho, Sunghyoun; Byeon, Haewon. "Alterations in mitochondrial biogenesis and regulation of morphology in lymphoblasts from amyotrophic lateral sclerosis patients". Trabalho apresentado em 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. 10.14257/astl.2016.132.36 Cho, Sunghyoun; Byeon, Haewon. "Understanding the influence of SOD1 mutation on mitochondrial mechanisms of autophagy and apoptosis in lymphoblasts from amyotrophic lateral sclerosis patients". Trabalho apresentado em 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. 10.14257/astl.2016.132.36 Leduc, A.. "Reprogramming forwards oxidative phosphorylation in breast cancer cell as potential drug targets". Trabalho apresentado em 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019. 10.1051/jtsfen/2016chi05p Silva, Filomena S.G.; Bento, Guida; Cunha-Oliveira, Teresa ; Oliveira, Paulo J. "Influence of SOD1 mutation on lymphoblast respiration and glycolytic rates from amyotrophic lateral sclerosis patients.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019. Bento, Guida; Siewiera, Karolina; Montezinho, Liliana ; Oliveira, Paulo J ; Silva, Filomena SG. "Understanding the cell growth profile of lymphoblasts to study as a model to discover the amyotrophic lateral sclerosis disease mechanisms.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019. Silva, Filomena S.G.; Komlodi, Timea; Garcia-Souza, Luiz F ; Oliveira, Paulo J ; Gnaiger, Erich. "Effect of etomoxir on mitochondrial function assessed by high-resolution respirometry.". Trabalho apresentado em 52th Annual Scientific Meeting of the European Society for Clinical Investigation, 2018. Silva, Filomena S.G.. "Establishing a new model for toxicological evaluation combining Sulforhodamine B and resazurin in human cells.". Trabalho apresentado em 50th Annual Scientific Meeting of the European Society for Clinical Investigation, 2016. Ribeiro MP; Silva FS; Sousa MC; Santos AE; Custódio JB. "Retinoids and antiestrogens: a new combined therapy for cancer treatment?". Trabalho apresentado em XX Porto Cancer Meeting, 2011. Ribeiro MP; Silva FS; Santos AE; Custódio JB. "Effects of endoxifen on mitochondrial functions". Trabalho apresentado em Targeting Mitochondria, 2011. Silva FS; Fernandes JC; Rocha-Pereira P; Custódio JB; Santos-Silva A. "Evaluation of the cytogenotoxic potential of isotretinoin and acitretin in cultured human blood lymphocytes in vitro". Trabalho apresentado em International Courses in Toxicology 2010 – Survival or Death as Matter of Fat, 2010. Silva FS; Fernandes JC; Rocha S; Rocha-Pereira P; Custódio JB; Santos-Silva A. "The cytogenotoxic effects of isotretinoin and acitretin on human lymphocytes cultures in vitro". Trabalho apresentado em IV Workshop em Bioquímica Clínica, 2010. Santos M; Almeida S; Silva FS; Santos-Silva E; Santos-Silva A; Rocha-Pereira P. "Baixo peso ao nascimento - O papel do laboratório na avaliação de fatores de risco para doença cardiovascular". Trabalho apresentado em 3º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas, 2009. Capote TC; Silva FS; Marques PF; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of homocysteine in the mitochondrial permeability transition pore opening". Trabalho apresentado em Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology, 2008. Marques PF; Silva FS; Capote TC; Machado M; Sousa MC; Rocha-Pereira P; Custódio JB. "p-Cymene and 2-nitro-p-cymene effects on the oxidative phosphorylation of rat liver mitochondria". Trabalho apresentado em Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology, 2008. Silva FS; Marques PF; Capote TC; Machado M; Sousa MC; Rocha-Pereira P; Custódio JB. "Effects of essential oils constituent p-cymene on bioenergetic functions of rat liver mitochondria". Trabalho apresentado em 15th International Congress on in vitro toxicology, 2008. Silva FS; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Therapeutical association of retinoic acids with antiestrogenic compounds: potential application in therapy of inflammatory skin disorders and breast cancer". Trabalho apresentado em Workshop Bioquímica Clínica, Doenças Emergentes Século XXI, 2008. Silva FS; Sardão VA; Oliveira PJ; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of 13-cis-RA and acitretin on tumour cell proliferation and isolated liver mitochondria". Trabalho apresentado em XVIth National Congresso of Biochemistry, 2008. Custódio JB; Silva FS; Capote TC; Marques RJ; Machado M; Rocha-Pereira P; Cavaleiro C; Sousa MC. "Essential oils constituent p-cymene induces proton leak in rat liver mitochondria". Trabalho apresentado em XVIth National Congresso of Biochemistry, 2008. Silva FS; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of 13-cis-retinoic acid and acitretin on bioenergetic functions of rat liver mitochondria". Trabalho apresentado em XVIth National Congresso of Biochemistry, 2008. Santos M; Almeida S; Silva FS; Santos-Silva E; Santos-Silva A; Rocha-Pereira P. "Low birth weight –prognostic risk value". Trabalho apresentado em XVI National Congress of Biochemistry, 2008. Silva FS; Santos MS; Moreira PI; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effects of the 13-cis-retinoic acid on the oxidative phosphorylation of rat liver mitochondria". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry, 2007. Custódio JB; Silva FS; Moreira PI; Santos-Silva A; Rocha-Pereira P; Santos MS. "13-cis-retinoic acid interacting with adenosine nucleotide translocase causes mitochondrial permeability transition". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry, 2007. Silva FS; Carvalho C; Marques RJ; Santos-Silva A; Rocha-Pereira P. "O papel da diabetes mellitus na doença cardiovascular em mulheres pós-menopausicas". Trabalho apresentado em 10as Jornadas Científicas de Análises Clínicas, 2006.
Tese / Dissertação	Silva, Filomena S.G.. "Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA". Doutoramento, Universidade de Coimbra, 2014. Silva, Filomena S.G.. ""Separation of plasmid DNA isoforms by pseudo-affinity chromatography with ligands L-histidine.". Licenciatura, Universidade da Beira Interior, 2006.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2019/07/08	Off-target effects of etomoxir on mitochondrial complex I.	12th MiP/MitoEAGLE Training School 2019. Mitochondrial respiratory physiology: Challenges on data sharing, reproducibility, and interpretation. (Coimbra, Portugal)
2019/05/22	Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir?	Pre-congress session \| MitoEAGLE COST Action: Mitochondrial - fitness mapping – Quality management network. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2018/09/18	The unspecific effect of etomoxir on mitochondrial respiration.	13th Conference on Mitochondrial Physiology: The role of mitochondria in health, disease and drug discovery - COST MitoEAGLE perspectives and MitoEAGLE WG and MC Meeting (Jurmala, Letónia)
2015/09/14	New valorization strategies for Eucalyptus spp. bark extracts.	New valorization strategies for Eucalyptus spp. bark extracts, 3rd Edition of the International Conference WASTES: Solutions, Treatments and Opportunities (Viana do Castelo, Portugal)
2014/11/13	Characterization of toxicological effects of acitretin alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B- therapy.	II Jornadas Ibéricas de Toxicologia University of Beira Interior (Covilhã, Portugal)
2011	The combination of antiestrogens with retinoic acid does not enhance the toxic effects induced by the retinoid on bioenergetic functions	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica, X Reunião de Toxicologia (Coimbra, Portugal)
2011	Evaluation of the cytogenotoxic potential of acitretin in combination with antiestrogenic compounds on human lymphocytes cultures in vitro	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica, X Reunião de Toxicologia (Coimbra, Portugal)
2009	Inflamação, Dislipidémia, Hemostase- Que relação?	3º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas (Porto, Portugal)
2009	Adiponectina e risco cardiovascular em diabéticos tipo 2	3º Congresso Cientifico da Associação nacional de Laboratórios de Análises Clínicas (Porto, Portugal)
2008/05/30	Estudo de novas estratégias terapêuticas no cancro da pele e da mama.	Da Investigação à Pratica Clinica University of Beira Interior (Covilhã, Portugal)
2008	Inhibition of the adenine nucleotide translocar by 13-cis-retinoic acid and acitretin in vitro	Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology (Coimbra, Portugal)
2008	Associação terapêutica de ácidos retinóicos e anti-estrogénios no cancro da pele e da mama: mecanismos moleculares de citotoxicidade	2º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas (Vilamoura, Portugal)
2008	Combined therapy of retinoic acids with antiestrogenic compounds: a potential application for therapy of inflammatory skin disorders and breast cancer	XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, VIII Reunião de Toxicologia (Lisboa, Portugal)
2008	Effect of carbamazepine, homocysteine and homocysteine tiolactone in the mitochondrial permeability transition pore opening	XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, VIII Reunião de Toxicologia (Lisboa, Portugal)
2007	13-cis-retinoic acid induces changes on the oxidative phosphorylation capacity of rat liver mitochondria	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia (Coimbra, Portugal)
2007	Interactions of 13-cis-retinoic acid with adenosine nucleotide translocase mechanisms of mitochondrial permeability transition induction	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia (Coimbra, Portugal)
2007	Effect of acitretin in the mitochondrial permeability transition pore opening	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia (Coimbra, Portugal)
2007	p-Cymene and 2-nitro-p-cymene effects on the oxidative phosphorylation of rat liver mitochondria	XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia (Coimbra, Portugal)
2006	Plasmids production and purification by pseudo-affinity chromatography	I CICS Symposium, Universidade da Beira Interior (Covilhã, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2019/09 - 2020/05	Oxidative stress mechanisms and parameters of mitochondrial dysfunction in lymphoblasts from patients with Amyotrophic Lateral Sclerosis. Orientador
2019/04/29 - 2019/08/30	Alterations in mitochondrial biogenesis and regulation of morphology in lymphoblasts from Amyotrophic Lateral Sclerosis patients Orientador	Biotechnology (Licenciatura/Bacharelato) Polytecnic Institute of Coimbra, Coimbra College of Agriculture , Portugal
2019/04/29 - 2019/08/30	A influência da mutação da SOD1 nos mecanismos mitocondriais de autofagia e apoptose em linfoblastos de pacientes com esclerose lateral amiotrófica - "Influence of SOD1 mutation on the mitochondrial mechanisms of autophagy and apoptosis in lymphoblasts from patients with amyotrophic lateral sclerosis" Orientador	Biotechnology (Licenciatura/Bacharelato)

Distinções

Outra distinção

2008	Prize awarded to the best oral paper presented in “2º Congresso Científico da Associação Nacional de Laboratórios Clínicos” Associação Nacional de Laboratórios Clínicos, Portugal
2007	Merit Scholarship for the best classification of Biochemistry graduation Universidade da Beira Interior, Portugal
2004	Merit Scholarship for the best student of Biochemistry graduation (2003/4) Universidade da Beira Interior, Portugal