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Identificação

Identificação pessoal

Nome completo
CLÉVIO DAVID RODRIGUES NÓBREGA

Nomes de citação

  • Nóbrega, Clévio David Rodrigues

Identificadores de autor

Ciência ID
C510-7F41-BAF8
ORCID iD
0000-0002-8312-5292

Endereços de correio eletrónico

  • cdnobrega@ualg.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2011
Concluído
Curso de Empreendedorismo (Curso médio)
Universidade de Coimbra, Portugal
2009 - 2009
Concluído
Lentiviral production training (Curso médio)
INSERM, França
2009
Concluído
Curso de Experimentação Animal - FELASA categoria C (Curso médio)
Insituto de Biologia Molecular e Celular, Portugal
2008 - 2008
Concluído
Lentiviral production training (Curso médio)
Universite de Lausanne, Suiça
2002 - 2007
Concluído
Biologia Molecular e Citogenética (Doutoramento)
Universidade da Madeira, Portugal
"A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: Insights into the speciation process of D. madeirensis" (TESE/DISSERTAÇÃO)
aprovado distinção e louvor
2004
Concluído
Genealogies and phylogenies of DNA: reconstruccion and aplications (Pós-Graduação)
Universitat de Barcelona, Espanha
Aprovado
2002
Concluído
Curso Avançado em Biologia Molecular (Pós-Graduação)
Universidade Nova de Lisboa, Portugal
1995 - 2000
Concluído
Biologia, Ramo Científico (Licenciatura)
Universidade da Madeira, Portugal
"Análise genética do isolamento reprodutor entre D. subobscura e D. madeirensis. Estudo de 3 genes: yellow, antennae color e RNA polimerase II do cromossoma X" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

2015/01 - 2016/08 Investigador Contratado (Investigação)
Universidade de Coimbra, Portugal
2007/10 - 2014/12 Pós-doutorado (Investigação)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01 - 2007/10 Pós-doutorado (Investigação)
Universitat de Barcelona, Espanha
2002/04 - 2006/12 Investigador (Investigação)
Universidade da Madeira, Portugal
2001/09 - 2002/03 Estagiário de Investigação (Investigação)
Universidade da Madeira, Portugal

Docência no Ensino Superior

2016/09 - Atual Professor Auxiliar (Docente Universitário)
Universidade do Algarve, Portugal

Cargos e Funções

2018/12 - Atual Dirigente de laboratório, instituto, museu, centro ou observatório
Universidade do Algarve, Portugal
2016 - Atual Conselho científico/técnico-científico ou orgão correspondente
Universidade do Algarve, Portugal
Projetos

Projeto

Designação Financiadores
2021 - Atual ALgarve Fit Ageing Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
072586
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2019 - Atual Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases.
#22424
Investigador responsável
The French Muscular Dystrophy Association (AFM)
2018 - Atual The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy
"PTDC/MED-NEU/29480/2017 ALG-01-0145-FEDER-29480 ""SeGrPolyQ"""
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2018 - 2021/12/31 Using an OMICS approach to found new genetic profiles associated with obesity
NA
Investigador
Instituto de Salud Carlos III
2020 - 2020/08/11 Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Investigador responsável
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2020/01 Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK
ZUNIALGA
Investigador responsável
Ataxia UK
2017 - 2017/12/31 Integración de varias omicas para el estudio de la obesidad
NA
Investigador
Fundación Investigación Hospital General Universitario de Valencia
2015 - 2017/03 Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation
18876
Investigador responsável
The French Muscular Dystrophy Association (AFM)
2014 - 2015/12/31 The role of ataxin-2 in Machado-Joseph disease: a molecular therapy approach with viral vectors.
NA
Investigador responsável
National Ataxia Foundation
2013 - 2015/02 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
Provided by PTCRIS: 125208
125208
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2014/04 Silencing Machado-Joseph Disease through the systemic route
125367
Provided by PTCRIS: 125367
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/04 The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
Provided by PTCRIS: 70384
70384
99307
Provided by PTCRIS: 99307
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2011/12/31 Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease
NA
Investigador
The French Muscular Dystrophy Association (AFM)
2010 - 2010/12/31 Modulation of autophagy as a novel therapeutic strategy for Machado-Joseph disease.
NA
Investigador
National Ataxia Foundation

Outro

Designação Financiadores
2021 - Atual Investigação de terapias experimentais em estudos pré-clínicos para o Síndroma de Cockayne
431#ABC-RI)
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Nóbrega, Clévio David Rodrigues. "Mapping gene expression in social anxiety reveals the main brain structures involved in this disorder". Brain Behavioural Research 394 (2021):
    Publicado
  2. Nóbrega, Clévio David Rodrigues. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021):
    Publicado
  3. Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x.
    10.1186/s13104-020-05053-x
  4. Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2.
    10.1186/s12967-020-02302-2
  5. Nóbrega, Clévio David Rodrigues. "Lauroylated Histidine-Enriched S4 13-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research 37 (2020):
    Publicado
  6. Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Carlos A Matos; Clévio Nóbrega. "MSGP: the first database of the protein components of the mammalian stress granules". Database (2019): https://doi.org/10.1093/database/baz031.
    10.1093/database/baz031
  7. Adriana Marcelo; Filipa Brito; Sara Carmo-Silva; Carlos A Matos; João Alves-Cruzeiro; Ana Vasconcelos-Ferreira; Rebekah Koppenol; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddy328.
    10.1093/hmg/ddy328
  8. Nóbrega, C.; Mendonça, L.; Marcelo, A.; Lamazière, A.; Tomé, S.; Despres, G.; Matos, C.A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067663327&partnerID=MN8TOARS.
    10.1007/s00401-019-02019-7
  9. Mendonça, L.S.; Nóbrega, C.; Tavino, S.; Brinkhaus, M.; Matos, C.; Tomé, S.; Moreira, R.; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models". Human molecular genetics 28 22 (2019): 3691-3703. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077346304&partnerID=MN8TOARS.
    10.1093/hmg/ddz097
  10. Nóbrega, C.; Codêsso, J.M.; Mendonça, L.; Pereira De Almeida, L.. "RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy 30 7 (2019): 841-854. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069664080&partnerID=MN8TOARS.
    10.1089/hum.2018.157
  11. Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541.
    10.1111/jnc.14541
  12. Nóbrega, Clévio; Alves, Sandro. "Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases". Frontiers in Neuroscience 12 (2018): http://dx.doi.org/10.3389/fnins.2018.00425.
    10.3389/fnins.2018.00425
  13. Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS.
    10.1016/j.ymthe.2018.07.007
  14. Mendonça, L.S.; Onofre, I.; Miranda, C.O.; Perfeito, R.; Nóbrega, C.; de Almeida, L.P.. "Stem Cell-Based Therapies for Polyglutamine Diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041956170&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_21
  15. Nóbrega, C.; Simões, A.T.; Duarte-Neves, J.; Duarte, S.; Vasconcelos-Ferreira, A.; Cunha-Santos, J.; Pereira, D.; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041952619&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_18
  16. Matos, C.A.; Carmona, V.; Vijayakumar, U.-G.; Lopes, S.; Albuquerque, P.; Conceição, M.; Nobre, R.J.; Nóbrega, C.; de Almeida, L.P.. "Gene therapies for polyglutamine diseases". 1049 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041963917&partnerID=MN8TOARS.
    10.1007/978-3-319-71779-1_20
  17. Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C.. "Unraveling the Role of Ataxin-2 in Metabolism". Trends in Endocrinology and Metabolism 28 4 (2017): 309-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009726744&partnerID=MN8TOARS.
    10.1016/j.tem.2016.12.006
  18. Albuquerque, D.; Nóbrega, C.; Manco, L.; Padez, C.. "The contribution of genetics and environment to obesity". British Medical Bulletin 123 1 (2017): 159-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029678152&partnerID=MN8TOARS.
    10.1093/bmb/ldx022
  19. Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS.
    10.2174/1381612822666161227121912
  20. Alves-Cruzeiro, João M. Da Conceição; Mendonça, Liliana; Pereira de Almeida, Luís; Nóbrega, Clévio. "Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review". Frontiers in Neuroscience 10 (2016): http://dx.doi.org/10.3389/fnins.2016.00572.
    10.3389/fnins.2016.00572
  21. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956644943&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2015.12.021
  22. Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS.
    10.1016/j.dib.2016.01.017
  23. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  24. Aveleira CA; Botelho M; Carmo-Silva S; Pascoal JF; Ferreira-Marques M; Nóbrega C; Cortes L; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons.". (2015): http://europepmc.org/abstract/med/25775546.
    10.1073/pnas.1416609112
  25. Albuquerque D; Stice E; Rodríguez-López R; Manco L; Nóbrega C; Albuquerque, David; Stice, Eric; et al. "Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.". (2015): http://europepmc.org/abstract/med/25749980.
    10.1007/s00438-015-1015-9
  26. Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L.. "Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease". Brain 138 12 (2015): 3537-3554. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951031850&partnerID=MN8TOARS.
    10.1093/brain/awv298
  27. Albuquerque, David; Nóbrega, Clévio; Rodríguez-López, Raquel; Manco, Licínio. "Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children". Journal of Human Genetics 59 6 (2014): 307-313. http://dx.doi.org/10.1038/jhg.2014.23.
    10.1038/jhg.2014.23
  28. Albuquerque, David; Estévez, Manuela Núñez; Víbora, Pilar Beato; Giralt, Plácida Sánchez; Balsera, Aránzazu Margallo; Cortés, Pedro Gil; López, Mercedes Jiménez; et al. "Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Iberian Population". Annals of Human Genetics 78 3 (2014): 195-207. http://dx.doi.org/10.1111/ahg.12058.
    Publicado • 10.1111/ahg.12058
  29. Mendonca, L. S.; Nobrega, C.; Hirai, H.; Kaspar, B. K.; Pereira de Almeida, L.. "Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice". Brain n 19 Dec (2014): 1-9.
    Publicado • 10.1093/brain/awu352
  30. Nobrega, Clevio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Deglon, Nicole; Pereira de Almeida, Luis. "RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of machado-joseph disease.". PloS one 9 8 (2014): e100086-e100086. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25144231&KeyUID=MEDLINE:25144231.
    10.1371/journal.pone.0100086
  31. Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children". Acta Paediatrica 102 4 (2013): e153-e157. http://dx.doi.org/10.1111/apa.12134.
    10.1111/apa.12134
  32. Nascimento-Ferreira, I.; Nobrega, C.; Vasconcelos-Ferreira, A.; Onofre, I.; Albuquerque, D; Aveleira, C.; Hirai, H.; Deglon, N.; Pereira de Almeida, L.. "Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease". Brain 136 7 (2013): 2173-2188.
    Publicado • 10.1093/brain/awt144
  33. Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. "Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children". PLoS ONE 8 1 (2013): e54370-e54370.
    Publicado • 10.1371/journal.pone.0054370
  34. Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira. "Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice". PLoS ONE 8 1 (2013): e52396-e52396.
    Publicado • 10.1371/journal.pone.0052396
  35. Monteiro, António; Nóbrega, Clévio; Abrantes, Isabel; Gomes, Celeste. "Diagnosing Portuguese Students' Misconceptions about the Mineral Concept". International Journal of Science Education 12 (2012): 1-22.
    Publicado • 10.1080/09500693.2012.731617
  36. Costa, P. M.; Cardoso, A. L.; Nobrega, C.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C.. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics 22 5 (2012): 904-918.
    Publicado • 10.1093/hmg/dds496
  37. Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; Almeida, Luís Pereira. "Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology". The Cerebellum . (2012): .-..
    Publicado • 10.1007/s12311-012-0432-0
  38. Albuquerque D; Nóbrega C; Samouda H; Manco L; Albuquerque, D; Nóbrega, Clévio David Rodrigues; Hanene Samouda; Manco, Licínio. "Assessment of obesity and abdominal obesity among Portuguese children.". Acta Medica Portuguesa 25 3 (2012): 169-173. http://europepmc.org/abstract/med/23069237.
    Publicado
  39. Albuquerque, D.; Nóbrega, C.; Samouda, H.; Manco, L.. "Assessment of obesity and abdominal obesity among Portuguese children,Avaliação da obesidade e obesidade abdominal em crianças Portuguesas". Acta Medica Portuguesa 25 3 (2012): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866904803&partnerID=MN8TOARS.
  40. Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al. "Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats". PLoS ONE 6 7 (2011): 22333-22333.
    Publicado • 10.1371/journal.pone.0022333
  41. Khadem, M.; Camacho, R.; Nobrega, C.; Nóbrega, Clévio David Rodrigues; Mahnaz Khadem; Roberto Camacho. "Studies of the species barrier between Drosophila subobscura and D-madeirensis V: the importance of sex-linked inversion in preserving species identity". Journal of Evolutionary Biology 24 6 (2011): 1263-1273. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000290313500011&KeyUID=WOS:000290313500011.
    Publicado • 10.1111/j.1420-9101.2011.02263.x
  42. Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al. "Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?". Human Molecular Genetics 19 12 (2010): 2380-2394.
    Publicado • 10.1093/hmg/ddq111
  43. Nobrega, C.; Khadem, M; Aguade, M.; Segarra, C. "Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura". Molecular Biology and Evolution 25 8 (2008): 1534-1543.
    Publicado • 10.1093/molbev/msn100
Capítulo de livro
  1. Albuquerque, David; Carmo-Silva, Sara; Álvarez-Vaca, Daniel; Aveleira, Célia; Nóbrega, Clévio. "Role of Mitochondrial Dysfunction in Human Obesity". In Handbook of Mitochondrial Dysfunction, 379-388. CRC Press, 2019.
    10.1201/9780429443336-30
  2. Albuquerque, D.; Manco, L.; Nóbrega, C.. "Molecular biology of human obesity: Nonepigenetics in comparison with epigenetic processes". 585-602. 2019.
  3. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. "Molecular Biology of Human Obesity: Non-epigenetics in Comparison with Epigenetic Processes". In Handbook of Nutrition, Diet, and Epigenetics, 1-18. Springer International Publishing, 2017.
    10.1007/978-3-319-31143-2_7-1
  4. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. "Genetics of Human Obesity". In Obesity, 87-106. Springer International Publishing, 2016.
    10.1007/978-3-319-19821-7_7
  5. Nóbrega, Clévio David Rodrigues. "Genetic contribution: Common forms of Obesity". In Molecular mechanisms underpinning the development of obesity, 37-56. US: Springer, 2015.
    Publicado
  6. Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Nóbrega, Clévio David Rodrigues. "Epigenetics of Human Obesity: A Link Between Genetics and Nutrition". In Molecular Mechanisms Underpinning the Development of Obesity, 101-127. US: Springer International Publishing, 2014.
    Publicado • 10.1007/978-3-319-12766-8_8
  7. Nobrega, Clevio; de Almeida, L. P.. "Machado-Joseph Disease / Spinocerebellar Ataxia Type 3". In Spinocerebellar Ataxia, 103-138. Croatia: InTech, 2012.
    Publicado • 10.5772/28576
Edição de livro
  1. Nóbrega, Clévio David Rodrigues. Polyglutamine Disorders. Springer International Publishing. 2018.
    10.1007/978-3-319-71779-1
  2. Nóbrega, Clévio David Rodrigues ; Sandro Alves. Gene Silencing and Editing Strategies for Neurodegenerative Diseases. Frontiers Media SA. 2018.
    10.3389/978-2-88945-551-5
  3. Nóbrega, Clévio David Rodrigues; Rodríguez-López, Raquel. Molecular mechanisms underpinning the development of obesity. US: Springer. 2015.
    Publicado
Livro
  1. Nóbrega, Clévio David Rodrigues ; Liliana Mendonça; Carlos A Matos. A Handbook of Gene and Cell Therapy. Springer. 2020.
Poster em conferência
  1. Nóbrega, Clévio David Rodrigues. "Silencing of CypX gene in the hypothalamus and its impact on whole-body metabolism". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020.
  2. Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for spinocerebellar ataxia type 2". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020.
  3. Nóbrega, Clévio David Rodrigues. "RBP-X modulates progerin levels and ameliorates its associated abnormalities in cellular models of HGPS". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020.
  4. Nóbrega, Clévio David Rodrigues. "Mitigating the Progeroid Phenotype: A Gene Delivery Strategy to Improve Progerin-Associated Abnormalities". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  5. Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Trabalho apresentado em FENS 2020 Virtual Forum, 2020.
  6. Nóbrega, Clévio David Rodrigues. "An RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  7. Nóbrega, Clévio David Rodrigues. "An RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  8. Nóbrega, Clévio David Rodrigues. "Autophagy Impairment in Spinocerebellar Ataxia Type 2: First Evidences and a Potential Therapeutic Strategy". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  9. Nóbrega, Clévio David Rodrigues. "Silencing ATXN2 expression using CRISPR/Cas9". Trabalho apresentado em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2020.
  10. Nóbrega, Clévio David Rodrigues. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Trabalho apresentado em International Research Ataxia Conference (IARC) 2019, 2019.
  11. Nóbrega, Clévio David Rodrigues. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Trabalho apresentado em MJD International Research Conference, 2019.
  12. Nóbrega, Clévio David Rodrigues. "CYP46A1-Gene therapy alleviates Machado-Joseph disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  13. Nóbrega, Clévio David Rodrigues. "On the role of stress granules in autophagy". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  14. Nóbrega, Clévio David Rodrigues. "RNA-binding proteins: new molecular targets for Polyglutamine diseases?". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  15. Nóbrega, Clévio David Rodrigues. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  16. Nóbrega, Clévio David Rodrigues. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Health, 2019.
  17. Nóbrega, Clévio David Rodrigues. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Conference on Clocks in Model Organisms: Circadian Networks, Physiology and Health, 2019.
  18. Nóbrega, Clévio David Rodrigues. "Estudo do papel de uma proteína de ligação ao RNA na expressão de lamina e progerina". Trabalho apresentado em 5th MEEting of UAlg Medicine Students, 2019.
  19. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, 2018.
  20. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm". Trabalho apresentado em Chrononutrition: From Epidemiology to Molecular Mechanism Symposium, London, 2018.
  21. Nóbrega, Clévio David Rodrigues. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Trabalho apresentado em European Society of Gene and Cell Therapy congress, 2018.
  22. Kumar, Sajal; Zhong, Hua; Sharma, Ruby; Li, Yiyi; Song, Mingzhou. "RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy". Trabalho apresentado em 11th Forum of Neuroscience (FENS), 2018.
    10.1109/bibm.2018.8621502
  23. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 a novel regulator of circadian rhythm". Trabalho apresentado em EMBO|EMBL Symposium: Biological Oscillators: Design, Mechanism, Function, 2018.
  24. Nóbrega, Clévio David Rodrigues. "Estudo do papel da autofagia na dispersão dos grânulos de stress". Trabalho apresentado em 4th MEEting of UAlg Medicine Students, 2018.
  25. Nóbrega, Clévio David Rodrigues. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017.
  26. Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), 2017.
  27. Nóbrega, Clévio David Rodrigues. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), 2017.
  28. Nóbrega, Clévio David Rodrigues. "Evaluation of proinflammatory cytokines expression in cells infected with coxsakievirus". Trabalho apresentado em XXVIII Congresso Brasileiro de Virologia, 2017.
  29. Nóbrega, Clévio David Rodrigues. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neurosciences, 2017.
  30. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2: a new player in central regulation of energy balance". Trabalho apresentado em EMBO Workshop – Neural control of metabolism and eating behaviour, 2016.
  31. Nóbrega, Clévio David Rodrigues. "Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism". Trabalho apresentado em XIII CNC Annual Meeting, 2015.
  32. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease". Trabalho apresentado em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2015.
  33. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". Trabalho apresentado em 11th NPY-PYY-PP International Meeting, 2015.
  34. Nóbrega, Clévio David Rodrigues. "Impact of hypothalamic ataxin-2 on energy balance and metabolic profile". Trabalho apresentado em 9th World Congress of the International Brain Research Organization (IBRO, 2015.
  35. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, 2015.
  36. Nóbrega, Clévio David Rodrigues. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease". Trabalho apresentado em International Society for Stem Cell Research (ISSCR) 2015 annual meeting, 2015.
  37. Nóbrega, Clévio David Rodrigues. "Gene editing strategies towards Machado Joseph disease". Trabalho apresentado em EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification", 2015.
  38. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 regulates energy balance and metabolism". Trabalho apresentado em Keystone Symposia, Neural Control of Metabolic Physiology and Diseases, 2015.
  39. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 regulates energy balance and metabolism". Trabalho apresentado em Keystone Symposia, Neural Control of Metabolic Physiology and Diseases, 2015.
  40. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging". Trabalho apresentado em XII CNC Anual Meeting, 2014.
  41. Nóbrega, Clévio David Rodrigues. "Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em XII CNC Anual Meeting, 2014.
  42. Nóbrega, Clévio David Rodrigues. "Association between obesity and polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5, and OLFM4 genes among Portuguese children". Trabalho apresentado em 21st European Congress on Obesity (ECO2014), 2014.
  43. Nóbrega, Clévio David Rodrigues. "Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  44. Nóbrega, Clévio David Rodrigues. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  45. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  46. Nóbrega, Clévio David Rodrigues. "Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  47. Nóbrega, Clévio David Rodrigues. "Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  48. Nóbrega, Clévio David Rodrigues. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Trabalho apresentado em Champalimaud Neuroscience Programme Symposium, 2013.
  49. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em 13th Meeting of the Portuguese Society for Neuroscience (SPN), 2013.
  50. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging". Trabalho apresentado em 7th Progeria Research Foundation International Workshop – Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, 2013.
  51. Nóbrega, Clévio David Rodrigues. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, 2012.
  52. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y is an autophagy inducer in hypothalamic neurons". Trabalho apresentado em IX Center for Neuroscience and Cell Biology (CNC) Annual Meetin, 2012.
  53. Nóbrega, Clévio David Rodrigues. "Associação do polimorfismo -13910C>T à obesidade abdominal em crianças portuguesas". Trabalho apresentado em 16º Congresso Português de Obesidade, 2012.
  54. Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neuopathology in Machado-Joseph disease transgenic mice". Trabalho apresentado em The 8th FENS Forum of Neuroscience, 2012.
  55. Marzocchi, N.; Severi, S.; Pieri, M.; Zona, C.; Cavalcanti, S.. "Beclin-1 mitigates motor and neuropathological déficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Trabalho apresentado em The 8th FENS Forum of Neuroscience, 2012.
    10.2495/bio050221
  56. Nóbrega, Clévio David Rodrigues. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Trabalho apresentado em 19th European Congress on Obesity (ECO2012), 2012.
  57. Nóbrega, Clévio David Rodrigues. "RNA interference rescues cerebellar abnormalities and ataxia in a lentiviral-based model of Machado-Joseph disease". Trabalho apresentado em The National Ataxia Foundation 55th annual membership meeting, 2012.
  58. Nóbrega, Clévio David Rodrigues. "Polymorphism rs9939609 in the FTO gene is associated with obesity among Portuguese children". Trabalho apresentado em 15ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2011.
  59. Kai, Kazuharu; Saya, Hideyuki; Hortobagyi, Gabriel N.; Ueno, Naoto T.. "Excitotoxicity in cerebellar granule cells transduced with mutant ataxin-3". Trabalho apresentado em Champalimaud Neuroscience Symposium, Champalimaud Foundation, 2011.
    10.1158/1538-7445.am10-2458
  60. Nóbrega, Clévio David Rodrigues. "RNA interference rescues motor and neurological deficits in Machado-Joseph disease rodent models". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011.
  61. Nóbrega, Clévio David Rodrigues. "Overexpression of the autophagic beclin-1 protein mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011.
  62. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Trabalho apresentado em CAG triplet disorders Gordon Research Conference, 2011.
  63. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction". Trabalho apresentado em 40th annual meeting of the Society for Neurosciences, 2010.
  64. Nóbrega, Clévio David Rodrigues. "Lentiviral injection of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction: can beclin-1 overexpression improve the pathological phenotype?". Trabalho apresentado em 18th ESGCT Annual Congress, 2010.
  65. Nóbrega, Clévio David Rodrigues. "Overexpression of mutant ataxin-3 in mousecerebellum induces behavioral deficits". Trabalho apresentado em Harvard Medical School: Molecular Mechanism in Neurodegeneration: from molecule to cure, 2010.
  66. Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin¬3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neurosciences, 2009.
  67. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains prevents translocation of mutant ataxin¬3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado¬Joseph Disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  68. Nóbrega, Clévio David Rodrigues. "Inhibition of calpains in a lentiviral mouse model of Machado¬Joseph Disease". Trabalho apresentado em CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008.
  69. Nóbrega, Clévio David Rodrigues. "A new therapeutic approach to AMD (degenerative macular age-related disease)". Trabalho apresentado em CONSERT labcourse, Advanced Couse Symposium and Pratical Training, 2008.
  70. Nóbrega, Clévio David Rodrigues. "A multilocus survey of nucleotide variation in Drosophila madeirensis, an endemic species to Madeira Island". Trabalho apresentado em XIX European Drosophila Research Conference, 2005.
Resumo em conferência
  1. Nóbrega, Clévio David Rodrigues. "PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE". 2021.
    Publicado • 10.1097/MD.0000000000023585
  2. Nóbrega, Clévio David Rodrigues. "MITIGATING THE PROGEROID PHENOTYPE: A GENE DELIVERY STRATEGY TO IMPROVE PROGERIN-ASSOCIATED ABNORMALITIES". 2021.
    Aceite para publicação • 10.1097/MD.0000000000023585
  3. Nóbrega, Clévio David Rodrigues. "AN RNA BINDING PROTEIN ALLEVIATES PATHOLOGY IN TWO DIFFERENT MOUSE MODELS OF POLYGLUTAMINE DISEASES". 2021.
    Publicado • 10.1097/MD.0000000000023585
  4. Nóbrega, Clévio David Rodrigues. "AUTOPHAGY IMPAIRMENT IN SPINOCEREBELLAR ATAXIA TYPE 2: FIRST EVIDENCES AND A POTENTIAL THERAPEUTIC STRATEGY". 2021.
    10.1097/MD.0000000000023585
  5. Nóbrega, Clévio David Rodrigues. "SILENCING ATXN2 EXPRESSION USING CRISPR/CAS9". 2021.
    Publicado • 10.1097/MD.0000000000023585
  6. Nóbrega, Clévio David Rodrigues. "CYP46A1- gene therapy improves Machado-Joseph disease in mouse models". 2020.
    Publicado
  7. Nóbrega, Clévio David Rodrigues. "Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock". 2020.
    Publicado • 10.1111/obr.13115
  8. Nóbrega, Clévio David Rodrigues. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". 2019.
    Publicado
  9. Nóbrega, Clévio David Rodrigues. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease". 2018.
    Publicado
  10. Nóbrega, Clévio David Rodrigues. "Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies". 2017.
    Publicado
  11. Nóbrega, Clévio David Rodrigues. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". 2016.
    Publicado • 10.1016/j.npep.2015.11.035
  12. Nóbrega, Clévio David Rodrigues. "Role of MicroRNA deregulation in Machado-Joseph disease". 2015.
    https://doi.org/10.1016/S1525-0016(16)34191-0
  13. Nóbrega, Clévio David Rodrigues. "MicroRNA-139-5p: a tool for metastasis and chemotherapeutic resistance control in pancreatic adenocarcinoma". 2014.
    Publicado
  14. Osokina, Irina. "Association study of several common polymorphisms with obesity and obesity-related traits among Portuguese children". 2014.
    Publicado • 10.1136/archdischild-2019-epa.639
  15. Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2013.
    Publicado
  16. Albuquerque, David; Jacobs, J; Nóbrega, Clévio David Rodrigues; Hanen, Samouda; Manco, Licínio. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Trabalho apresentado em 19th European Congress on Obesity (ECO2012), Lyon, 2012.
    Publicado • 10.1159/000228822
  17. Nóbrega, Clévio David Rodrigues. "Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice". 2011.
    Publicado
  18. Nóbrega, Clévio David Rodrigues. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease". 2010.
    Publicado
  19. Nóbrega, Clévio David Rodrigues. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". 2009.
    Publicado
Tese / Dissertação
  1. Nóbrega, Clévio David Rodrigues. "A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: insights into the speciation process of D. madeirensis". Doutoramento, 2007. http://hdl.handle.net/10400.13/1429.
Website
  1. Nóbrega, Clévio David Rodrigues. Mammalian stress granules proteome. 2019. https://msgp.pt/.

Propriedade Intelectual

Patente
  1. Nóbrega, Clévio David Rodrigues. 2018. "Expression vector for cholesterol 24-hydrolase in therapy of polyglutamine repeat spinocerebellar ataxias".
    Concedida/Emitida
  2. Nóbrega, Clévio David Rodrigues. 2014. "Neuropeptide Y overexpression for use in the treatment of premature aging".
    Concedida/Emitida

Outros

Outra produção
  1. Nóbrega, Clévio; Almeida, Luís Pereira de. 2018. Polyglutamine disorders preface. http://hdl.handle.net/10400.1/11962.
    10.1007/978-3-319-71779-1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 MAPPING THE DOMAINS OF RBP-X TOWARDS MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN POLYGLUTAMINE DISEASE MODELS 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 "RBP-X PROTEIN MITIGATES MOTOR DEFICITS IN DIFFERENT MICE MODELS OF POLYGLUTAMINE DISEASES" 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 CRISPR/CAS9-MEDIATED SILENCING OF ATXN2 EXPRESSION 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 MIXCAPAAV1/2 VECTOR: A NOVEL GENE DELIVERY SYSTEM DISTRIBUTION, SPREADING AND TROPISM ANALYSIS IN NORMAL MICE 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 AUTOPHAGY DYSFUNCTION IN SPINOCEREBELLAR ATAXIA TYPE 2 MODELS AND A POTENTIAL THERAPEUTIC STRATEGY 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 HYPOTHALAMIC NEUROPEPTIDE Y (NPY) AMELIORATES THE AGING PHENOTYPE OF A MOUSE MODEL OF HUMAN AGING 51ª Reunião da Sociedade Portuguesa de Farmacologia
2021 Development of gene therapy strategies: lessons from preclinical studies
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck
2021 Molecular therapies for Polyglutamine diseases: lessons from preclinical studies
Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM)
2020 Overexpression of a Specific RNA-binding Protein Ameliorates Several Abnormalities in Cellular Models of Progeria 50th SPF Annual Meeting
2020 RNA-binding proteins as potential therapeutic targets for Polyglutamine diseases 50th SPF Annual Meeting
2020 Stress granules crosstalk with autophagy in a context of polyglutamine diseases 50th SPF Annual Meeting
2020 Stress Granules dynamics in Polyglutamine diseases International Meeting of the Portuguese Society of Genetics
2020 Activation of autophagy as a molecular target for neurodegenerative diseases 2nd Joint WG4-WG5 Transautophagy Translational Workshop - European Network of Multidisciplinary Research and Translation of Autophagy knowledge (TRANSAUTOPHAGY)
2020 Towards a therapy for polyglutamine diseases: lessons from preclinical studies Recent Trends in CNS Regenerative Medicine, ICVS
Universidade do Minho
2020 Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock European and International Congress of Obesity 2020 (ECO-ICO)
2020 PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2020 A renovação do colesterol cerebral nas ataxias espinocerebelosas: dos estudos pré-clínicos ao desenvolvimento de uma terapia III SIMPÓSIO EM INVESTIGAÇÃO DAS ESCOLAS MÉDICAS PORTUGUESAS
2019/06 Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2 Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Health
2019/04 Hypothalamic ataxin-2: Resetting the clock on obesity European Congress on Obesity ECO 2019
2019 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
2019 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease International Research Ataxia Conference (IARC) 2019
2019 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease MJD International Research Conference
2019 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease MJD International Research Conference
2019 CYP46A1- gene therapy improves Machado-Joseph disease in mouse models 23ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2019 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2019 Permanent inactivation of the ATXN3 gene: A possible therapeutic approach for Machado-Joseph disease XVI Meeting of the Portuguese Society for Neuroscience
2019 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2019 Development and characterization of a lentiviral mouse model for Spinocerebellar ataxia type 2 3as Jornadas Algarve Biomedical Center
2019 CYP46A1 overexpression alleviates Machado-Joseph disease XLIX Reunião da Sociedade Portuguesa de Farmacologia
2019 From the molecular pathogenesis to gene therapy 5º Meeting dos Mestrado Integrado em Medicina
2019 Towards a therapy for Polyglutamine diseases: lessons from preclinical studies
Interdisciplinary Center for Neuroscience
2019 Preclinical studies in spinocerebellar ataxias PhD Programme in Health Sciences (PhDHS), FMUC
Universidade de Coimbra
2019 Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy Neurodegenerative Diseases course at PDBEB
Centro de Neurociências e Biologia Celular
2018/11 Hypothalamic ataxin-2: a modulator of circadian rhythm and metabolism 22.º Congresso Português de Obesidade - Obesidade: Um peso a reduzir
2018/11 Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm Chrononutrition: From Epidemiology to Molecular Mechanism Symposium
2018 CYP46A1-gene therapy alleviates spinocerebellar ataxia in mouse models European Society of Gene and Cell Therapy congress
2018 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS Portuguese Society of Movement Disorders (SPDMov)
2018 Tailoring gene editing strategies for the treatment of Machado-Joseph disease Portuguese Society of Movement Disorders (SPDMov)
2018 Pharmacological targeting of AMPK signalling pathway as a therapeutic approach to Polyglutamine diseaes XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 MicroRNA dysregulation in Machado-Joseph disease: from pathogenesis to therapy XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 Ibuprofen decreases neuroinflammation and improves neuropathology and motor impariments in Machado-Joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 Hypothalamic ataxin-2 regulates circadian rhythm in mice XLVIII Reunião da Sociedade Portuguesa de Farmacologia
2018 Towards a therapy for Polyglutamine diseases: lessons from preclinical studies Rare Diseases and Orphan Drugs Global Forum 2018
2018 Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy Annual Meeting of the Portuguese Society of Genetics
2018 Polyglutamine disorders 2as Jornadas do Algarve Biomedical Center
2018 Polyglutamine diseases: learning from molecular pathogenesis to develop therapies
Distinguished seminar, ISAZA/CBMR, Universidade do Algarve
2018 Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy Neurodegenerative Disorders course at PDBEB
CNC
2017 Role of RNA binding proteins in polyglutamine diseases 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2017 miRNA-mediated cis-regulation in breast cancer susceptibility 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2017 Targeting AMPK as a therapeutic strategy to spinocerebellar ataxias 2nd CBMR/ProRegeM Annual Meeting
2017 TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease 2nd International Ataxia Research Conference (IARC)
2017 Role of stress granules in spinocerebellar ataxias XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Gene editing strategies for Machado-Joseph disease XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Sustainable alleviation of motor impairments and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in Machado-Joseph disease mice XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseh disease XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Vasconcelos-Ferreira A, NÓBREGA CLÉVIO, Verbeek D, Schmidt T, Pereira de Almeida L, Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 PERK inhibition in spinocerebellar ataxias XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Hypothalamic ataxin-2 modulates body weight and insulin sensitivity XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Autophagy is stimulated by NPY Y1 and Y5 receptors activation in hypothalamic neurons XLVII Reunião da Sociedade Portuguesa de Farmacologia
2017 Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies 26th ISN-ESN Biennial Meeting
2017 Viral-based systems for gene delivery Workshop Gene Delivery for Biomedical Applications
Universidade do Algarve
2016 Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease Brain Without Borders Meeting
2016 Hypothalamic ataxin-2 contributes to energy balance regulation and metabolism XLVI Reunião da Sociedade Portuguesa de Farmacologia
2016 Cordycepin: a pharmacological approach to modulate mutant ataxin-3 and it use as a potential therapeutic effect in Machado-Joseph Disease XLVI Reunião da Sociedade Portuguesa de Farmacologia
2016 Reestablishing Ataxin -2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2016 Regulation of translation of Ataxin-3 by Ataxin-2 The 10th World Congress on Controversies in Neurology (CONy)
2016 Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches
CBMR, Universidade do Algarve
2016 Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches Advanced therapies course at PDBEB
CNC
2016 Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches Principles and practice in drug development course at PDBEB
CNC
2015 Scanning of animal brain sections as tool for research Quantitative Fluorescence Microscopy Course, CNC
CNC
2015 Interacting ataxins: from regulated to pathological protein aggregation Neurodegenerative Disorders course at PDBEB
CNC
2015 Lentiviral vectors for in vivo gene transfer: gene silencing and autophagy activation Principles and practice in drug development course at PDBEB
CNC
2014 Lauroyl derivatives of H5-S413-PV as novel cell-penetrating peptides for siRNA delivery XVIII Congress of the Portuguese Biochemical Society (SPB)
2014 Mesenchymal stem cells for Machado-Joseph disease therapy XVIII Congress of the Portuguese Biochemical Society (SPB)
2014 Protein phosphorylation as a toxicity modulator in Machado-Joseph disease XVIII Congress of the Portuguese Biochemical Society (SPB)
2014 Autophagic Flux Is Stimulated By Npy In Hypothalamic Neurons And Is Relevant To Synaptic Plasticity Of Pomc Hypothalamic Neurons XII CNC Meeting
2014 Cerebellar transplantation of mesenchymal stromal cells alleviates motor impairments and neuropathology of a transgenic mouse model of Machado-Joseph disease Term Stem Conference
2014 Hypothalamic Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging XLIII Reunião da Sociedade Portuguesa de Farmacologia
2014 Neuropeptide Y, a caloric restriction mimetic, promotes autophagy in hypothalamic neurons XLIII Reunião da Sociedade Portuguesa de Farmacologia
2014 Ataxin-2 as a molecular target in Machado-Joseph disease: from translation modulation to disease alleviation
CNC Seminars
2013 Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease XIII Reunião da Sociedade Portuguesa de Neurociências
2013 Estudo de polimorfismos genéticos associados à obesidade comum em crianças de naturalidade Portuguesa 17º congresso da Sociedade Portuguesa para o Estudo da Obesidade
2013 Screening for melanocortin-4 receptor mutations in a cohort of Portuguese children with severe obesity I BioAnthropological Meeting: a multidisciplinary approach (IBAM)
2013 Silencing Machado-Joseph disease in the cerebellum Gene and Cell therapy of CNS: from microRNAs to iPS cells and gene repair course at PDBEB
CNC
2012 Silencing of mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice Ataxia Research Conference
2012 Beclin-1 mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease Ataxia Research Conference
2012 Genetic profile of obesity-related polymorphisms among Portuguese children 16º Congresso Português de Obesidade
2011 RNA interference rescues motor and neuropathological deficits in Machado-Joseph disease rodent models 41th annual meeting of the Society for Neurosciences
2011 Associação do polimorfismo rs9939609 à obesidade em crianças Portuguesas 15º Congresso Português de Obesidade
2011 Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice European Society for Gene and Cell Therapy / British Society for Gene Therapy collaborative Congress
2011 Beclin-1 gene transfer rescues the motor phenotype of a transgenic mouse model of Machado-Joseph disease XXXVI Portuguese Workshops in Genetics
2011 Overexpression of mutant ataxin-3 in the cerebellum induces behavioural deficits XLI Reunião da Sociedade Portuguesa de Farmacologia
2011 Activation of the autophagy pathway rescues motor and neurological deficits in a transgenic mouse model of Machado- Joseph disease XLI Reunião da Sociedade Portuguesa de Farmacologia
2009 Effects of overexpression or silencing of neuropeptide Y in the rat hypothalamic arcuate nucleus achieved by viral vector approach in feeding behaviour XL Reunião da Sociedade Portuguesa de Farmacologia
2009 Inhibition of calpains in a lentiviral mouse model of MJD prevents nuclear localization and reduces neuronal dysfunction and degeneration V International Workshop on Machado-Joseph disease
2006 Molecular characterization of D. madeirensis: an endemic species closely related to D. subobscura VI Jornadas de Biologia Evolutiva
2005 Variabilitat nucleotídica a gens candidats V Jornadas de Biologia Evolutiva
2004 Aproximación multilocus o genómica XV Seminario de Genética de Poblaciones y Evolución
2003 Evolució Molecular a regiones Genòmiques implicades, directa o indirectament, en característiques adaptatives III Jornadas de Biologia Evolutiva

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021 - Atual Brain-targeted lipid-based nanovesicles to deliver brain plasticity modulators – a strategy to enhance brain cell-replacement therapeutics in Machado-Joseph disease
Coorientador
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra, Portugal
2020 - Atual Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics
Orientador
Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2020 - Atual Connecting mutant Ataxin-2 and synaptic disfunction: are stress granules the link?
Orientador
Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2020 - Atual Spreading of mutant ataxin-2 through microvesicles
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2020 - Atual Protein synthesis and ageing: is translation rate a major regulator?
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2020 - Atual Connecting aging genes and mutant ataxin-2 induced neurodegeneration
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - Atual Targeting the ATXN2 gene with the CRISPR-Cas9 system as a therapeutic strategy for spinocerebellar ataxia type 2
Orientador
Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2019 - Atual On the role of brain ataxin-2 in whole-body aging
Orientador
Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado)
Universidade do Algarve, Portugal
2019 - Atual Role of neuronal cholesterol in peripheric tissues
Orientador
Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado)
Universidade do Algarve, Portugal
2017 - Atual Stress granules in Polyglutamine diseases: new targets for therapeutic intervention?
Orientador
Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2013 - Atual Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease
Coorientador
Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra, Portugal
2019 - 2020 A neuroendocrine strategy to delay aging
Coorientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Coorientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 Ciliary recruitment of Dynein-2 motor and its role in C. elegans sensory functions, with emphasis in male mating behavior
Coorientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas
Orientador
Ciências Farmacêuticas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 Controlling the effect of injection in the hypothalamus of diet-induced obese mice
Orientador
Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 On the role of an RNA-binding protein in a transgenic mouse model of Polyglutamine diseases
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 The impact of aging in mutant ataxin-2 induced neurodegeneration
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2018 - 2020 Targeting hypothalamus: diet impact, bacterial composition and memory impair
Coorientador
Biologia Molecular e Microbiana (Mestrado)
Universidade do Algarve, Portugal
2018 - 2020 Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism
Orientador
Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado)
Universidade do Algarve, Portugal
2018 - 2019 Insights into the role of G3BP1 on Polyglutamine diseases
Orientador
Biologia Molecular e Microbiana (Mestrado)
Universidade do Algarve, Portugal
2017 - 2019 On the role of stress granules in autophagy
Orientador
Neurociências (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018 Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2
Orientador
Ciências Biomédicas (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - 2018 A catalogue of mammalian stress granules components: implications for neurodegeneration
Orientador
Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado)
Universidade do Algarve, Portugal
2015 - 2016 PERK inhibition role in Spinocerebellar ataxias
Orientador
Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra, Portugal
2015 - 2016 INSIGHTS INTO THE ROLE OF STRESS GRANULES IN SPINOCEREBELLAR ATAXIAS
Orientador
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2015 - 2016 Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type 2
Orientador
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2014 - 2015 Pharmacological modulation of mutant ataxin-3 translation and it potential therapeutic effect in Machado Joseph disease
Orientador
Investigação Biomédica (Mestrado)
Universidade de Coimbra, Portugal
2011 - 2015 Study of genetic variants associated with obesity in Portuguese children
Coorientador
Doutoramento em Antropologia, na especialidade de Antropologia Biológica (Doutoramento)
Universidade de Coimbra, Portugal
2011 - 2012 Pharmacological activation of autophagy in Machado-Joseph disease
Coorientador
Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2020 Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism
Orientador
Adriana Arrulo (Mestrado)
Universidade do Algarve, Portugal
2020 Targeting hypothalamus: diet impact, bacterial composition and memory impair
Orientador
Bruno Várzea (Mestrado)
Universidade do Algarve, Portugal
2020 InCited2 secrete cardiogenic molecules
Arguente principal
João André Lopes (Mestrado)
Universidade do Algarve, Portugal
2020 Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas
Orientador
Carolina Biscaia (Mestrado)
Universidade do Algarve, Portugal
2020 A NEUROENDOCRINE STRATEGY TO DELAY AGING
Orientador
Hélio Conceição (Mestrado)
Universidade do Algarve, Portugal
2020 Estudo do papel de uma proteína ligante de RNA num modelo animal das doenças de poliglutaminas
Orientador
Joana Pinto (Mestrado)
Universidade do Algarve, Portugal
2020 The impact of aging in mutant ataxin-2 induced neurodegeneration
Orientador
Patrícia Lima (Mestrado)
Universidade do Algarve, Portugal
2020 Functional studies on ZEB transcription factors in glioblastoma
Presidente do júri
Nuno Ramalho (Mestrado)
Universidade do Algarve, Portugal
2020 Controlling the effect of injection in the hypothalamus of diet-induced obese mice
Orientador
Renata Sandres Souza Araújo (Mestrado)
Universidade do Algarve, Portugal
2019 On the persistence of therapy: the potential of miRNA modulation in Alzheimer disease
Arguente principal
Ana Teresa de Barros Viegas (Doutoramento)
Universidade de Coimbra, Portugal
2019 Insights into the role of G3BP1 on Polyglutamine diseases
Orientador
Diogo Teixeira (Mestrado)
Universidade do Algarve, Portugal
2019 Estudo comparativo e diferencial dos genes Mob: os interactuantes proteicos e expressão transcricional em contextos de normalidade e tumorais
Arguente principal
Ricardo Resende (Mestrado)
Universidade do Algarve, Portugal
2019 Patient-specific iPSC-derived NESC for Machado-Joseph disease treatment
Arguente principal
Vanessa Alexandra Castanheira (Mestrado)
Universidade de Coimbra, Portugal
2019 Toward the isolation of exosomes by flow cytometry.
Arguente principal
André Mozes (Mestrado)
Universidade do Algarve, Portugal
2019 Study of the TRIB2 protein network.
Arguente principal
Catarina Raposo (Mestrado)
Universidade do Algarve, Portugal
2019 On the role of stress granules in autophagy.
Orientador
Rebekah Koppenol (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 Understanding the potential of PDMAEMA-based vectors for gene therapy of the retina.
Arguente principal
Diogo Miguel Barros Bitoque (Doutoramento)
Universidade Nova de Lisboa, Portugal
2018 Identification of S-Nitrosylated proteins in injury-induced neurogenesis.
Vogal
Ana Sofia Lourenço (Doutoramento)
Universidade do Algarve, Portugal
2018 Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2
Orientador
Marta Santos (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease.
Arguente principal
Udaya Geetha Vijayakumar (Doutoramento)
Universidade de Coimbra, Portugal
2017 Unravelling the role of ataxin-2 in the hypothalamus: a new player in metabolism.
Arguente
Sara Matias Carmo Silva (Doutoramento)
Universidade de Coimbra, Portugal
2017 Abordagem terapêutica na doença de Alzheimer?
Arguente principal
Bárbara Martins Sousa (Mestrado)
Universidade do Algarve, Portugal
2016 Neuropeptide Y gene transfer for neuroprotection in Machado-Joseph Disease
Vogal
Joana Filipa Duarte das Neves (Doutoramento)
Universidade de Coimbra, Portugal
2016 Clarifying the mechanism of action of trehalose on alleviating MJD.
Arguente principal
Allyson Trevino Garcia (Mestrado)
Universidade de Coimbra, Portugal
2016 Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type.
Orientador
João Alves-Cruzeiro (Mestrado)
Hospitais da Universidade de Coimbra, Portugal
2016 Insights into the role of stress granules in spinocerebellar ataxias.
Orientador
Sandra Tomé (Mestrado)
Universidade de Coimbra, Portugal
2016 Strategies to reverse celular senescence and enhance progerin clearance in Hutchinson-Gilford progeria syndrome.
Arguente principal
Ana Sofia Leal (Mestrado)
Universidade de Coimbra, Portugal
2016 Characterization of mitochondrial function and dynamics in models of Machado-Joseph disease.
Arguente principal
Filipa Almeida (Mestrado)
Universidade de Coimbra, Portugal
2015 Optimization of a viral culture system to evaluate antiviral activity
Arguente principal
Nânci Lúcia Ferreira (Mestrado)
Universidade de Coimbra, Portugal
2013 Caracterização do perfil genómico do carcinoma pulmonar
Arguente principal
Sérgio Portovedo (Mestrado)
Universidade de Coimbra, Portugal
2012 Pharmacological activation of autophagy in Machado Joseph disease
Orientador
Ana Cristina Vasconcelos Ferreira (Mestrado)
Universidade de Coimbra, Portugal
2012 Immobilization of Metalloproteins for Biotechnogical Applications
Arguente principal
Tânia Isabel Rodrigues Genebra (Mestrado)
Universidade de Coimbra, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019/06 - Atual XVI Meeting of the Portuguese Society for Neuroscience Lisboa
Distinções

Prémio

2018 Janssen Innovation Award (2nd edition)
2017 Young Scientist Lectureship Award
2016 Human Genetics Portuguese Society Award