Margarida Espadinha graduated in Applied Chemistry (Organic Chemistry field) in 2013 from the Faculty of Sciences and Technology of the New University of Lisbon and, in 2015, obtained her MSc degree in Bioorganic Chemistry at the same University. After a short stay at the Institute of chemistry CNRS (Nice, France), under a STSM-CM1106 supported by the Cost Action, she started a research grant funded by pharmaceutical company Hovione in colaboration with Santos’ group at the Faculty of Pharmacy of University of Lisbon. In October 2021, she completed a PhD in Pharmacy at the Faculty of Pharmacy of University of Lisbon. During her PhD, she worked on the development of novel p53 activators by targeting p53 protein-protein interactions as an anticancer approach, under the supervision of Prof. Maria M. M. Santos, Prof. Stuart J. Conway and Prof. Cecília Rodrigues. As part of her PhD project, she spent 6 months in the Conway Lab at the University of Oxford, UK, where she worked on the targeted protein degradation field. In November 2021, she joined the Medicinal Chemistry group at the University of Antwerp, in Belgium, as Postdoctoral Research Fellow. The current focus of her work is to investigate and develop selective serine dipeptidyl peptidase inhibitors and bivalent chemical degraders for cancer therapy, under the supervision of Prof. Pieter Van Der Veken.

Identificação pessoal

Nome completo
Margarida Leonor Florindo Espadinha

Nomes de citação

  • Espadinha, Margarida

Identificadores de autor

Ciência ID

Endereços de correio eletrónico

  • margarida.florindoespadinha@uantwerpen.be (Profissional)


  • University of Antwerp, Universiteitsplein 1 , 2610, Wilrijk, Wilrijk, Bélgica (Profissional)

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Analítica


Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Grau Classificação
2017 - 2021/10/04
Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017
MedChemTrain (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
2013 - 2015
Química Bioorgânica (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Enantiopure Bicyclic Lactams: Synthesis and Biological Evaluation" (TESE/DISSERTAÇÃO)
2010 - 2013
Química Aplicada (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Development of New Synthetic Method to Obtain Propofol Metabolites" (TESE/DISSERTAÇÃO)
Percurso profissional


Categoria Profissional
Instituição de acolhimento
2021/11/01 - Atual Pós-doutorado (Investigação) Universiteit Antwerpen, Bélgica
Universiteit Antwerpen Departement Farmaceutische Wetenschappen, Bélgica
2017/09/01 - 2021/10/04 Investigador (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal


Artigo em revista
  1. Espadinha, Margarida; Lopes, Elizabeth A.; Marques, Vanda; Amaral, Joana D.; dos Santos, Daniel J.V.A.; Mori, Mattia; Daniele, Simona; et al. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): 114637. http://dx.doi.org/10.1016/j.ejmech.2022.114637.
    Publicado • 10.1016/j.ejmech.2022.114637
  2. Espadinha, Margarida; Barcherini, Valentina; Gonçalves, Lídia M.; Molins, Elies; Antunes, Alexandra M. M.; Santos, Maria M. M.. "Tryptophanol-Derived Oxazolopyrrolidone Lactams as Potential Anticancer Agents against Gastric Adenocarcinoma". Pharmaceuticals 14 3 (2021): 208. http://dx.doi.org/10.3390/ph14030208.
    Publicado • 10.3390/ph14030208
  3. Raposo, Luís R.; Silva, Ana; Silva, Dário; Roma-Rodrigues, Catarina; Espadinha, Margarida; Baptista, Pedro V.; Santos, Maria M.M.; Fernandes, Alexandra R.. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880. http://dx.doi.org/10.1016/j.bmc.2020.115880.
  4. Espadinha, Margarida; Viejo, Lucía; Lopes, Ricardo M.R.M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J.V.A.; Gonçalves, Lídia; et al. "Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders". European Journal of Medicinal Chemistry 194 (2020): 112242. http://dx.doi.org/10.1016/j.ejmech.2020.112242.
    Publicado • 10.1016/j.ejmech.2020.112242
  5. Raimundo, Liliana; Espadinha, Margarida; Soares, Joana; Loureiro, Joana B; Alves, Marco G; Santos, Maria M M; Saraiva, Lucília. "Improving anticancer activity towards colon cancer cells with a new p53-activating agent". British Journal of Pharmacology 175 20 (2018): 3947-3962. http://dx.doi.org/10.1111/bph.14468.
    Publicado • 10.1111/bph.14468
  6. Espadinha, Margarida; Lourenço, Nuno M. T.; Sobral, Luis; Antunes, Rafael; Santos, Maria M. M.. "A More Sustainable Process for Preparation of the Muscarinic Acetylcholine Antagonist Umeclidinium Bromide". ChemMedChem 13 19 (2018): 2053-2056. http://dx.doi.org/10.1002/cmdc.201800387.
    Publicado • 10.1002/cmdc.201800387
  7. Espadinha, Margarida; Barcherini, Valentina; Lopes, Elizabeth A.; Santos, Maria M.M.. "An Update on MDMX and Dual MDM2/X Inhibitors". Current Topics in Medicinal Chemistry 18 8 (2018): 647-660. http://dx.doi.org/10.2174/1568026618666180604080119.
    Publicado • 10.2174/1568026618666180604080119
  8. Soares, Joana; Espadinha, Margarida; Raimundo, Liliana; Ramos, Helena; Gomes, Ana Sara; Gomes, Sara; Loureiro, Joana B.; et al. "DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties". Molecular Oncology 11 6 (2017): 612-627. http://dx.doi.org/10.1002/1878-0261.12051.
    Publicado • 10.1002/1878-0261.12051
  9. Espadinha, Margarida; Dourado, Jorge; Lajarin-Cuesta, Rocio; Herrera-Arozamena, Clara; Gonçalves, Lidia M. D.; Rodríguez-Franco, María Isabel; de los Rios, Cristobal; Santos, Maria M. M.. "Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists". ChemMedChem 12 7 (2017): 537-545. http://dx.doi.org/10.1002/cmdc.201700037.
    Publicado • 10.1002/cmdc.201700037
  10. Ribeiro, Carlos J.A.; Espadinha, Margarida; Machado, Marta; Gut, Jiri; Gonçalves, Lídia M.; Rosenthal, Philip J.; Prudêncio, Miguel; Moreira, Rui; Santos, Maria M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic & Medicinal Chemistry 24 8 (2016): 1786-1792. http://dx.doi.org/10.1016/j.bmc.2016.03.005.
    Publicado • 10.1016/j.bmc.2016.03.005
  11. Perez, Maria; Espadinha, Margarida; Santos, Maria. "Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis". Current Pharmaceutical Design 21 38 (2015): 5518-5546. http://dx.doi.org/10.2174/1381612821666151002112934.
    Publicado • 10.2174/1381612821666151002112934
Capítulo de livro
  1. Espadinha, Margarida; Conway, Stuart J.; Santos, Maria M.M.. "PPIs as therapeutic targets for anticancer drug discovery: the case study of MDM2 and BET bromodomain inhibitors". In Small Molecule Drug Discovery, 267-288. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-818349-6.00010-8

Propriedade Intelectual

  1. Espadinha, Margarida. 2019. "Process for the Preparation of Umeclidinium Bromide".


2022 Seal of Excellence for the proposal submitted to Marie Sklodowska-Curie Actions Postdoctoral Fellowships 2021 call
European Commission, Bélgica
2022 Best poster/oral communication by VII SEQT Summer School
2021 Best PhD Thesis in Medicinal Chemistry 2021 by the Medicinal Chemistry Division of the Portuguese Chemical Society (SPQ)
Sociedade Portuguesa de Bioquímica, Portugal
2019 EFMC grant to attend the 8th EFMC International Symposium on Advanced in Synthetic and Medicinal Chemistry and the 6th EFMC Young Medicinal Chemist Symposium in Athens, Greece.
2018 Best Poster Prize / E. A. Lopes, M. Espadinha, M. Mori, M. Botta, M. M. M. Santos, “Spiropyrazoline oxindoles – promising dual inhibitors of p53-MDM2/X PPIs”, Cost Action CM1407 5th MC/WG Meeting, Salini Resort, Malta, 1-2 March 2018
2018 Best Presentation / Barcherini V., Espadinha M., Soares J., Antunes A., Saraiva L., Santos M. M. M., "Enantiopure oxazoloisoindolinones: Promising small molecules for p53-based therapy with potential anticancer properties", 4th Intern. Elect. Conference