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Olga Borges leads a research group on "vaccines and adjuvants" within the biotechnology field at CNC (Center for Neuroscience and Cell Biology). Her research projects aim not only at developing adjuvants for subunit vaccines but also for DNA and mRNA vaccines. Particularly, the group has several objectives, including developing therapeutic vaccines and vaccines that can be effective through different administration routes from the conventional route, such as oral and intranasal administration. According to Google Scholar, researcher Olga Borges is the author of 84 scientific documents cited 2399 times, with an h-index of 26 and an i10-index of 46. Scopus lists 61 documents authored by her with a total of 1885 citations and an h-index of 25. Olga Borges was included in the "World's Top 2% Scientist 2021 and 2022" list, the most influential scientists, as disclosed by the Elsevier editorial group. She contributed to the writing of 81 publications across various categories: editor of 1 book, author of 7 book chapters, 61 articles in ISI journals (4 submitted), author of 1 guideline, 2 articles in Portuguese journals, and 9 congress abstracts published in journals. Additionally, her scientific work has been presented in 57 oral presentations at congresses, symposiums, and workshops, and in 61 congress posters. Her contribution to these publications can be considered highly relevant, as she is the first author/corresponding author/last author in 75% of ISI articles and 71% of book chapters. It's worth noting that 80% of the publications in ISI journals correspond to laboratory research conducted entirely or largely in her laboratory, while the rest are review works. As the principal investigator (PI), she secured funding for her research group through 6 competitive projects she wrote and submitted to various funding entities: 2 projects from FCT (Portuguese Foundation for Science and Technology), 1 transnational FCT PROSAFE project involving research laboratories from 2 other countries (Romania and Switzerland), 1 project from Gilead Sciences, and 2 grants/prizes from private entities. In total, she has been responsible for securing €565,939.55 in funding through these 6 projects. She also directly contributed to the writing effort of 8 projects that led to the awarding of FCT doctoral scholarships, each for 4 years, as well as scholarships granted by CAPES (Brazil) for 1-year postdoc internships (3 students) and sandwich doctoral students (3 students). As a researcher, she is also involved in 12 other competitive projects funded and being developed at the University of Coimbra. She has received repeated invitations to be part of the editorial boards of journals. In total, she has served on 9 journals, including Vaccines (MDPI) and Frontiers, for which she has contributed to 6 special issues and is a regular editor for Vaccines. Olga Borges is a lecturer at the Faculty of Pharmacy of the University of Coimbra, where she has been teaching for 25 years. She has taught theoretical, theoretical-practical, and laboratory classes in 9 different curricular units and has been the coordinator of 5 curricular units, notably the curricular units she is currently teaching: Vaccine and Adjuvant Production Technology (optional); Pharmaceutical Technology II; Regulation in Drug Development. She has supervised over 43 final course projects (monographic review work), supervised 12 scientific master's students (completed), and has 6 master's students in the laboratory conducting scientific work. She has supervised 8 doctoral thesis students. She was the advisor for 5 Ph.D. students with completed theses defended at the University of Coimbra and 3 Brazilian students with completed sandwich doctoral degrees defended at Brazilian universities. Additionally, she has 3 Ph.D. students who will complete their theses in the next 1-2 years and 1 student who is just beginning. She also supervised 5 post-docs.
Identificação

Identificação pessoal

Nome completo
Olga Maria Fernandes Borges

Nomes de citação

  • Borges, Olga
  • Borges, O.

Identificadores de autor

Ciência ID
C31E-87B1-1363
ORCID iD
0000-0002-2215-5121
Scopus Author Id
8529429500

Endereços de correio eletrónico

  • olga@ci.uc.pt (Profissional)
  • oborges@ff.uc.pt (Profissional)

Telefones

Telefone
  • 239488428 (Profissional)

Moradas

  • Faculdade de Farmácia da Universidade de Coimbra. Pólo das Ciências da Saúde - Azinhaga de Santa Comba, 3000-548 , COIMBRA, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2007/05/16
Concluído
Curso de Experimentação animal (nível C da FELASA) (Título de Habilitação de Coordenação Científica)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2007/05/03
Concluído
Doutoramento em Farmácia (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Alginate coated chitosan nanoparticles as adjuvant for mucosal vaccination with hepatitis B antigen" (TESE/DISSERTAÇÃO)
Aprovado por unanimidade com distinção e louvor.
1996
Concluído
Mestrado em Ciência e Tecnologia dos Alimentos (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Contribuição para o estudo das alterações das proteínas do pescado conservado em congelado" (TESE/DISSERTAÇÃO)
Aprovado por unanimidade
1992
Concluído
Ciências Farmacêuticas (Ramo B- Indústria) (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Ciências Farmacêuticas " (TESE/DISSERTAÇÃO)
15 valores
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2007/05/03 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/01 - 2024/12/30 CiNTech
CiNTech
Investigador
2022/02/01 - 2023/02/28 Vacina Intranasal genética contra o COVID: estudos de imunização em murganhos
Investigador responsável
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Gilead Sciences
Concluído
2022 - 2023 Development of a food supplement based on Resveratrol for optimal CNS activity.
ReSet
Investigador
Concluído
2022 - 2023 Fighting Sars-CoV-2 with Viral Vectors
COVID-19. 01/08/2020-30/06/2023
Investigador
Concluído
2022 - 2023 BDforMJD
BDforMJD
Investigador
Concluído
2022 - 2023 ModelPolyQ2.0
ModelPolyQ2.0
Investigador
Concluído
2022 - 2023 MJDEDIT
CENTRO-01-0145-FEDER-181266
Investigador
Concluído
2018/03 - 2022/02 inpactus - Produtos e Tecnologias Inovadores a partir do Eucalipto
POCI-01-0247-FEDER-021874
Investigador
2020 - 2022 Impacto da ação de produtos naturais sobre células envolvidas na imunidade e em células tumorais humanas
# 88887.194785/2018-00
Investigador
Universidade Estadual Paulista Júlio de Mesquita Filho, Brasil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Em curso
2018/06 - 2021/06 Hepatitis B therapeutic vaccine: Production of glucan-based particles towards selective delivery core hepatitis B antigens to immune cells to induce antiviral activity
POCI-01-0145-FEDER-030331
Investigador responsável
CNC.IBILI, Portugal
Em curso
2018 - 2021 Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease
CENTRO-01-0145-FEDER-029369
Investigador
CNC.IBILI, Portugal
2018 - 2021 Giardia lamblia extracellular vesicles in modulation of host immune cells: potential application of Giardia EVs against intestinal inflammation
SAU-PAR/31506/2017
Investigador
CNC.IBILI, Portugal
Em curso
2017/04 - 2019/06 Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions - ProSafe JTC/0001/2016
ProSafe JTC/0001/2016
Investigador responsável
CNC.IBILI, Portugal
Concluído
2013 - 2015 Desenvolvimento de hidrogeis baseados em polissacarideos quimicamente modificados para aplicacao em libertacao controlada de farmacos de acao anticancerigena.
Proc. No 329/13
Investigador
2011/01/01 - 2014/01/01 Development of a mucosal hepatitis B vaccine: Design and mechanistic studies of a prototypic multi-component polymeric delivery system.
Investigador responsável
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2008 - 2010 Vacina de DNA para a hepatite B
not applicable
Investigador responsável
CNC.IBILI, Portugal
GlaxoSmithKline
Concluído
Produções

Publicações

Artigo em revista
  1. João Panão Costa; Sandra Jesus; Mariana Colaço; Alana Duarte; Edna Soares; Olga Borges. "Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies". Vaccine (2023): https://doi.org/10.1016/j.vaccine.2023.04.063.
    10.1016/j.vaccine.2023.04.063
  2. Bernardi, Natalia; Jesus, Sandra; Borges, Olga. "Synthetic and Natural Polymeric Drug Delivery Systems - A Comprehensive Overview of Polycaprolactone and Glucan Particles". Journal of Biomimetics, Biomaterials and Biomedical Engineering 59 (2023): 39-58. http://dx.doi.org/10.4028/p-ns8294.
    10.4028/p-ns8294
  3. Mariana Colaço; Tiago Roquito; João Panão Costa; Maria Teresa Cruz; Olga Borges. "The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020623.
    10.3390/pharmaceutics15020623
  4. Maruf, Ali; Milewska, Malgorzata; Kovács, Tibor; Varga, Máté; Vellai, Tibor; Lalik, Anna; Student, Sebastian; Borges, Olga; Wandzik, Ilona. "Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation". Biomaterials Advances 138 (2022): 212969. http://dx.doi.org/10.1016/j.bioadv.2022.212969.
    10.1016/j.bioadv.2022.212969
  5. Vilsinski, Bruno H.; Souza, Paulo R.; de Oliveira, Ariel C.; Filho, César M.C.; Valente, Artur J.M.; Muniz, Edvani C.; Borges, Olga; et al. "Photophysics and drug delivery behavior of methylene blue into Arabic-gum based hydrogel matrices". Materials Today Communications 26 (2021): 101889. http://dx.doi.org/10.1016/j.mtcomm.2020.101889.
  6. Sandra Jesus; Natalia Bernardi; Jessica da Silva; Mariana Colaço; João Panão Costa; Pedro Fonte; Olga Borges. "Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends". Chemical Research in Toxicology (2020): https://doi.org/10.1021/acs.chemrestox.0c00208.
    10.1021/acs.chemrestox.0c00208
  7. Vilsinski, Bruno H.; Souza, Paulo R.; de Oliveira, Ariel C.; Filho, César M.C.; Valente, Artur J.M.; Muniz, Edvani C.; Borges, Olga; et al. "Photophysics and drug delivery behavior of methylene blue into Arabic-gum based hydrogel matrices". Materials Today Communications (2020): 101889. http://dx.doi.org/10.1016/j.mtcomm.2020.101889.
    Publicado • 10.1016/j.mtcomm.2020.101889
  8. Chatzitaki, Aikaterini-Theodora; Jesus, Sandra; Karavasili, Christina; Andreadis, Dimitrios; Fatouros, Dimitrios G.; Borges, Olga. "Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation of efficacy and safety". International Journal of Pharmaceutics 589 (2020): 119776. http://dx.doi.org/10.1016/j.ijpharm.2020.119776.
    Publicado
  9. Borchard, Gerrit; Som, Claudia; Zinn, Manfred; Ostafe, Vasile; Borges, Olga; Perale, Giuseppe; Wick, Peter. "Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-by-Design Concepts". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.599950.
    10.3389/fbioe.2020.599950
  10. Colaço, Mariana; Duarte, Alana; Zuzarte, Mónica; Costa, Benilde F.O.; Borges, Olga. "Airborne environmental fine particles induce intense inflammatory response regardless of the absence of heavy metal elements". Ecotoxicology and Environmental Safety 195 (2020): 110500. http://dx.doi.org/10.1016/j.ecoenv.2020.110500.
    Publicado • 10.1016/j.ecoenv.2020.110500
  11. Schmutz, Mélanie; Borges, Olga; Jesus, Sandra; Borchard, Gerrit; Perale, Giuseppe; Zinn, Manfred; Sips, Ädrienne A. J. A. M; et al. "A Methodological Safe-by-Design Approach for the Development of Nanomedicines". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00258.
    10.3389/fbioe.2020.00258
  12. Colaço, Mariana; Marques, Ana P.; Jesus, Sandra; Duarte, Alana; Borges, Olga. "Safe-by-Design of Glucan Nanoparticles: Size Matters When Assessing the Immunotoxicity". Chemical Research in Toxicology (2020): http://dx.doi.org/10.1021/acs.chemrestox.9b00467.
    10.1021/acs.chemrestox.9b00467
  13. Marques, Cíntia; Som, Claudia; Schmutz, Mélanie; Borges, Olga; Borchard, Gerrit. "How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00165.
    Acesso aberto • Publicado • 10.3389/fbioe.2020.00165
  14. Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al. "Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00100.
    Acesso aberto • Publicado • 10.3389/fbioe.2020.00100
  15. Scariot, Débora B.; Volpato, Hélito; Fernandes, Nilma S.; Lazarin-Bidóia, Danielle; Borges, Olga; Sousa, Maria do Céu; Rosa, Fernanda A.; et al. "Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-56647-w.
    Publicado • 10.1038/s41598-019-56647-w
  16. Gaspar, André S.; Santos, Paulo H.C.; Borges, Olga; Costa, Benilde F.O.; Durães, Luisa. "Biocompatible and high-magnetically responsive iron oxide nanoparticles for protein loading". Journal of Physics and Chemistry of Solids 134 (2019): 273-285. http://dx.doi.org/10.1016/j.jpcs.2019.06.016.
    Publicado • 10.1016/j.jpcs.2019.06.016
  17. Jesus, Sandra; Schmutz, Mélanie; Som, Claudia; Borchard, Gerrit; Wick, Peter; Borges, Olga. "Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far". Frontiers in Bioengineering and Biotechnology 7 (2019): http://dx.doi.org/10.3389/fbioe.2019.00261.
    Acesso aberto • 10.3389/fbioe.2019.00261
  18. Filipa Lebre; Ed C. Lavelle; Olga Borges. "Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies". Journal of Pharmacy and Pharmacology (2019): https://doi.org/10.1111/jphp.13082.
    10.1111/jphp.13082
  19. Scariot, Débora Botura; Volpato, Hélito; Fernandes, Nilma de Souza; Soares, Edna Filipa Pais; Ueda-Nakamura, Tânia; Dias-Filho, Benedito Prado; Din, Zia Ud; et al. "Activity and Cell-Death Pathway in Leishmania infantum Induced by Sugiol: Vectorization Using Yeast Cell Wall Particles Obtained From Saccharomyces cerevisiae". Frontiers in Cellular and Infection Microbiology 9 (2019): http://dx.doi.org/10.3389/fcimb.2019.00208.
    10.3389/fcimb.2019.00208
  20. M. C. Almeida; D. Antunes; B. M. A. Silva; L. Rodrigues; M. Mota; O. Borges; C. Fernandes; T. Gonçalves. "Early Interaction of Alternaria infectoria Conidia with Macrophages". Mycopathologia 184 3 (2019): 383-392. https://doi.org/10.1007/s11046-019-00339-6.
    10.1007/s11046-019-00339-6
  21. Da Silva, Jessica; Jesus, Sandra; Bernardi, Natália; Colaço, Mariana; Borges, Olga. "Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases Its Immunotoxicity". Frontiers in Bioengineering and Biotechnology 7 (2019): http://dx.doi.org/10.3389/fbioe.2019.00137.
    10.3389/fbioe.2019.00137
  22. Edna Soares; Zwier M.A. Groothuismink; André Boonstra; Olga Borges. "Glucan Particles Are a Powerful Adjuvant for the HBsAg, Favoring Antiviral Immunity". Molecular Pharmaceutics (2019): https://doi.org/10.1021/acs.molpharmaceut.8b01322.
    10.1021/acs.molpharmaceut.8b01322
  23. Panão Costa, João; Carvalho, Sofia; Jesus, Sandra; Soares, Edna; Marques, Ana Patrícia; Borges, Olga. "Optimization of Chitosan-a-casein Nanoparticles for Improved Gene Delivery: Characterization, Stability, and Transfection Efficiency". AAPS PharmSciTech 20 3 (2019): http://dx.doi.org/10.1208/s12249-019-1342-y.
    Publicado • 10.1208/s12249-019-1342-y
  24. Bento, Dulce; Jesus, Sandra; Lebre, Filipa; Gonçalves, Teresa; Borges, Olga. "Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant". Pharmaceutics 11 2 (2019): 72. http://dx.doi.org/10.3390/pharmaceutics11020072.
    Acesso aberto • Publicado • 10.3390/pharmaceutics11020072
  25. Edna Soares; Rosemeyre Cordeiro; Henrique Faneca; Olga Borges. "Polymeric nanoengineered HBsAg DNA vaccine designed in combination with ß-glucan". International Journal of Biological Macromolecules 122 (2019): 930-939. https://doi.org/10.1016/j.ijbiomac.2018.11.024.
    10.1016/j.ijbiomac.2018.11.024
  26. Lebre, F.; Pedroso de Lima, M.C.; Lavelle, Ed C.; Borges, O.. "Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles". International Journal of Pharmaceutics 552 1-2 (2018): 7-15. http://dx.doi.org/10.1016/j.ijpharm.2018.09.044.
    10.1016/j.ijpharm.2018.09.044
  27. Volpato, Hélito; Scariot, Débora Botura; Soares, Edna Filipa Pais; Jacomini, Andrey Petita; Rosa, Fernanda Andreia; Sarragiotto, Maria Helena; Ueda-Nakamura, Tânia; et al. "In vitro anti-Leishmania activity of T6 synthetic compound encapsulated in yeast-derived ß-(1,3)-d-glucan particles". International Journal of Biological Macromolecules 119 (2018): 1264-1275. http://dx.doi.org/10.1016/j.ijbiomac.2018.08.019.
    10.1016/j.ijbiomac.2018.08.019
  28. Sandra Jesus; Edna Soares; Maria Teresa Cruz; Olga Borges. "Exosomes as adjuvants for the recombinant hepatitis B antigen: first report". European Journal of Pharmaceutics and Biopharmaceutics (2018): https://doi.org/10.1016/j.ejpb.2018.09.029.
    10.1016/j.ejpb.2018.09.029
  29. Edna Soares; Sandra Jesus; Olga Borges. "Chitosan:ß-glucan particles as a new adjuvant for the hepatitis B antigen". European Journal of Pharmaceutics and Biopharmaceutics 131 (2018): 33-43. https://doi.org/10.1016/j.ejpb.2018.07.018.
    10.1016/j.ejpb.2018.07.018
  30. Sandra Jesus; Edna Soares; Gerrit Borchard; Olga Borges. "Adjuvant Activity of Poly-e-caprolactone/Chitosan Nanoparticles Characterized by Mast Cell Activation and IFN-¿ and IL-17 Production". Molecular Pharmaceutics (2018): https://doi.org/10.1021/acs.molpharmaceut.7b00730.
    10.1021/acs.molpharmaceut.7b00730
  31. Soares, Edna; Jesus, Sandra; Borges, Olga. "Oral hepatitis B vaccine: chitosan or glucan based delivery systems for efficient HBsAg immunization following subcutaneous priming". International Journal of Pharmaceutics 535 1-2 (2018): 261-271. http://dx.doi.org/10.1016/j.ijpharm.2017.11.009.
    10.1016/j.ijpharm.2017.11.009
  32. Jesus, Sandra; Soares, Edna; Borchard, Gerrit; Borges, Olga. "Poly-¿-caprolactone/chitosan nanoparticles provide strong adjuvant effect for hepatitis B antigen". Nanomedicine 12 19 (2017): 2335-2348. http://dx.doi.org/10.2217/nnm-2017-0138.
    10.2217/nnm-2017-0138
  33. Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; de Lima, M.C. Pedroso; Borges, O.. "Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination". International Journal of Pharmaceutics 527 1-2 (2017): 103-114. http://dx.doi.org/10.1016/j.ijpharm.2017.05.028.
    10.1016/j.ijpharm.2017.05.028
  34. Jesus, Sandra; Fragal, Elizangela H.; Rubira, Adley F.; Muniz, Edvani C.; Valente, Artur J. M.; Borges, Olga. "The Inclusion of Chitosan in Poly-e-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure". AAPS PharmSciTech 19 1 (2017): 101-113. http://dx.doi.org/10.1208/s12249-017-0822-1.
    10.1208/s12249-017-0822-1
  35. Gerola, A.P.; Silva, D.C.; Matsushita, A.F.Y.; Borges, O.; Rubira, A.F.; Muniz, E.C.; Valente, A.J.M.. "The effect of methacrylation on the behavior of Gum Arabic as pH-responsive matrix for colon-specific drug delivery". European Polymer Journal 78 (2016): 326-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961886552&partnerID=MN8TOARS.
    10.1016/j.eurpolymj.2016.03.041
  36. Vilsinski, B.H.; Murtinho, D.M.B.; Serra, M.E.S.; Soares, E.F.P.; Cruz, P.F.; Braga, G.; Borges, O.; et al. "Interactions between copper(II) dibrominated salen complex and copolymeric micelles of P-123 and F-127". Colloids and Surfaces A: Physicochemical and Engineering Aspects (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85015694066&partnerID=MN8TOARS.
    10.1016/j.colsurfa.2017.02.079
  37. Lebre, F.; Borchard, G.; Faneca, H.; Pedroso De Lima, M.C.; Borges, O.. "Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice". Molecular Pharmaceutics 13 2 (2016): 472-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957308940&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.5b00707
  38. Jesus, S.; Soares, E.; Costa, J.; Borchard, G.; Borges, O.. "Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-e-caprolactone based nanoparticles". International Journal of Pharmaceutics 504 1-2 (2016): 59-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961918592&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2016.03.013
  39. Dulce Bento; Herman F. Staats; Olga Borges. "Effect of particulate adjuvant on the anthrax protective antigen dose required for effective nasal vaccination". Vaccine 33 31 (2015): 3609-3613. https://doi.org/10.1016/j.vaccine.2015.06.037.
    10.1016/j.vaccine.2015.06.037
  40. Almeida, M.S.; Borges, O.. "Nasal vaccines against hepatitis B: An update". Current Pharmaceutical Biotechnology 16 10 (2015): 882-890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939779701&partnerID=MN8TOARS.
  41. Gerola, A.P.; Silva, D.C.; Jesus, S.; Carvalho, R.A.; Rubira, A.F.; Muniz, E.C.; Borges, O.; Valente, A.J.M.. "Synthesis and controlled curcumin supramolecular complex release from pH-sensitive modified gum-arabic-based hydrogels". RSC Advances 5 115 (2015): 94519-94533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946854772&partnerID=MN8TOARS.
    10.1039/c5ra14331d
  42. Bento, D.; Staats, H.F.; Gonçalves, T.; Borges, O.. "Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity". European Journal of Pharmaceutics and Biopharmaceutics 93 (2015): 149-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927513193&partnerID=MN8TOARS.
    10.1016/j.ejpb.2015.03.024
  43. Bento, D.; Borchard, G.; Gonçalves, T.; Borges, O.. "Validation of a new 96-well plate spectrophotometric method for the quantification of compound 48/80 associated with particles". AAPS PharmSciTech 14 2 (2013): 649-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879080664&partnerID=MN8TOARS.
    10.1208/s12249-013-9950-4
  44. S, Jesus; O, Borges. "Freeze Dried Chitosan/ Poly-e-Caprolactone and Poly-e-Caprolactone Nanoparticles: Evaluation of their Potential as DNA and Antigen Delivery Systems". Journal of Genetic Syndromes & Gene Therapy 4 7 (2013): http://dx.doi.org/10.4172/2157-7412.1000164.
    Acesso aberto • Publicado • 10.4172/2157-7412.1000164
  45. Oliveira, C.R.; Rezende, C.M.F.; Silva, M.R.; Borges, O.M.; Pêgo, A.P.; Goes, A.M.. "Oral vaccination based on DNA-chitosan nanoparticles against schistosoma mansoni infection". The Scientific World Journal 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861034466&partnerID=MN8TOARS.
    10.1100/2012/938457
  46. Oliveira, C.R.; Rezende, C.M.F.; Silva, M.R.; Pêgo, A.P.; Borges, O.; Goes, A.M.. "A New Strategy Based on Smrho Protein Loaded Chitosan Nanoparticles as a Candidate Oral Vaccine against Schistosomiasis". PLoS Neglected Tropical Diseases 6 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870751323&partnerID=MN8TOARS.
    10.1371/journal.pntd.0001894
  47. Borges, Olga. "Development of chitosan nanoparticle-DNA complexes for nasal immunization against Hepatitis B - 4th BBBB International Conference on Pharmaceutical Sciences". European Journal of Pharmaceutical Sciences 44 (2011): 139-140. http://dx.doi.org/10.1016/j.ejps.2011.08.002.
    Publicado
  48. Borges, Olga. "Incorporation of a mast cell activator in chitosan based delivery systems for mucosal immunization - 4th BBBB International Conference on Pharmaceutical Sciences". European Journal of Pharmaceutical Sciences 44 (2011): 142-143. http://dx.doi.org/10.1016/j.ejps.2011.08.002.
    Publicado • 10.1016/j.ejps.2011.08.002
  49. Borges, Olga. "Effect of the inclusion of chitosan into poly-epsilon-caprolactone particles on adsorption efficacy of 4 different model antigens - 4th BBBB International Conference on Pharmaceutical Sciences". European Journal of Pharmaceutical Sciences 44 (2011): 135-136. http://dx.doi.org/10.1016/j.ejps.2011.08.002.
  50. Borges, Olga; Borchard, Gerrit. "Hepatitis B needle-free vaccines: a step closer". Clinical Investigation 1 6 (2011): 767-770. http://dx.doi.org/10.4155/cli.11.58.
    Acesso aberto • Publicado • 10.4155/cli.11.58
  51. Lebre, F.; Borchard, G.; De Lima, M.C.P.; Borges, O.. "Progress towards a needle-free hepatitis B vaccine". Pharmaceutical Research 28 5 (2011): 986-1012. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955607675&partnerID=MN8TOARS.
    10.1007/s11095-010-0314-4
  52. Jesus, Sandra; Borges, Olga. "Recent Developments in the Nasal Immunization against Anthrax". World Journal of Vaccines 01 03 (2011): 79-91. http://dx.doi.org/10.4236/wjv.2011.13008.
    Publicado • 10.4236/wjv.2011.13008
  53. Borges, O.; Lebre, F.; Bento, D.; Borchard, G.; Junginger, H.E.. "Mucosal vaccines: Recent progress in understanding the natural barriers". Pharmaceutical Research 27 2 (2010): 211-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949272140&partnerID=MN8TOARS.
    10.1007/s11095-009-0011-3
  54. Borges, O.; Cordeiro-da-Silva, A.; Tavares, J.; Santarém, N.; de Sousa, A.; Borchard, G.; Junginger, H.E.. "Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles". European Journal of Pharmaceutics and Biopharmaceutics 69 2 (2008): 405-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249088985&partnerID=MN8TOARS.
    10.1016/j.ejpb.2008.01.019
  55. Borges, O.; Silva, M.; de Sousa, A.; Borchard, G.; Junginger, H.E.; Cordeiro-da-Silva, A.. "Alginate coated chitosan nanoparticles are an effective subcutaneous adjuvant for hepatitis B surface antigen". International Immunopharmacology 8 13-14 (2008): 1773-1780. http://www.scopus.com/inward/record.url?eid=2-s2.0-55249098468&partnerID=MN8TOARS.
    10.1016/j.intimp.2008.08.013
  56. Borges, O.; Borchard, G.; de Sousa, A.; Junginger, H.E.; Cordeiro-da-Silva, A.. "Induction of lymphocytes activated marker CD69 following exposure to chitosan and alginate biopolymers". International Journal of Pharmaceutics 337 1-2 (2007): 254-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248584919&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2007.01.021
  57. Borges, O.; Tavares, J.; de Sousa, A.; Borchard, G.; Junginger, H.E.; Cordeiro-da-Silva, A.. "Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles". European Journal of Pharmaceutical Sciences 32 4-5 (2007): 278-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748974510&partnerID=MN8TOARS.
    10.1016/j.ejps.2007.08.005
  58. Borges, O.; Cordeiro-da-Silva, A.; Romeijn, S.G.; Amidi, M.; de Sousa, A.; Borchard, G.; Junginger, H.E.. "Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination". Journal of Controlled Release 114 3 (2006): 348-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748131292&partnerID=MN8TOARS.
    10.1016/j.jconrel.2006.06.011
  59. Borges, O.; Borchard, G.; Verhoef, J.C.; De Sousa, A.; Junginger, H.E.. "Preparation of coated nanoparticles for a new mucosal vaccine delivery system". International Journal of Pharmaceutics 299 1-2 (2005): 155-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844435468&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2005.04.037
  60. Valente, A.J.M.; Burrows, H.D.; Polishchuk, A.Ya.; Domingues, C.P.; Borges, O.M.F.; Eusébio, M.E.S.; Maria, T.M.R.; Lobo, V.M.M.; Monkman, A.P.. "Permeation of sodium dodecyl sulfate through polyaniline-modified cellulose acetate membranes". Polymer 46 16 (2005): 5918-5928. http://www.scopus.com/inward/record.url?eid=2-s2.0-21744450884&partnerID=MN8TOARS.
    Publicado • 10.1016/j.polymer.2005.05.103
Capítulo de livro
  1. Soares, Edna Filipa Pais; Borges, Olga. "Polymer-based adjuvant requirements for vaccines". In System vaccinology. Academic Press, 2022.
    Publicado
  2. Colaço, Mariana; Panão Costa, João; Borges, Olga. "Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant". In Methods in Molecular Biology, 269-280. Springer US, 2021.
    10.1007/978-1-0716-1892-9_13
  3. Schmutz, Mélanie; Borges, Olga; Borchard, Gerrit; Wick, Peter; Som, Claudia. "Guidelines as a starting point to address the needs of small and medium enterprises regarding the Safe-by-Design of polymeric nanobiomaterials for drug delivery". In Nanomaterials for Theranostics and Tissue Engineering, 259-271. Elsevier, 2020.
    10.1016/b978-0-12-817838-6.00010-3
  4. Jesus, S.; Soares, E.; Borges, O.. "Poly-e-caprolactone/chitosan and chitosan particles: Two recombinant antigen delivery systems for intranasal vaccination". In AAPS PharmSciTech. 2016.
    10.1007/978-1-4939-3389-1_45
  5. Borges, Olga. "Short Communications: Updates on Nanomaterials Properties". In Applied Nanotechnology - Materials and Applications, editado por Vladimir I. Kodolov Dsc Gennady E. Zaikov Dsc A. K. Haghi PhD. NJ 08758, Estados Unidos: Apple Academic Press Inc., 3333 Mistwell Crescent, Oakville, ON L6L 0A2, Canada; Apple Academic Press Inc., 9 Spinnaker Way, Waretown, 2016.
    Publicado
  6. Borges, O.; Borchard, G.. "Mucosal vaccination: Opportunities and challenges". In AAPS PharmSciTech. 2013.
    10.1007/978-1-4614-5380-2_3
  7. Lebre, F.; Bento, D.; Jesus, S.; Borges, O.. "Chitosan-Based Nanoparticles as a Hepatitis B Antigen Delivery System". In AAPS PharmSciTech. 2012.
    10.1016/B978-0-12-391858-1.00007-1
Livro
  1. Borges, Olga. Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts. Frontiers Media SA. 2020.
    10.3389/978-2-88966-256-2
Poster em conferência
  1. Jesus, Sandra; Da Silva, Jessica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester Nanoparticle Immunotoxicological Profile". Trabalho apresentado em Controlled Release Society Annual Meeting & Exposition, 2020.
  2. Soares, Edna; Borges, Olga. "Design of therapeutic hepatitis B vaccine: chitosan/glucan nanoparticles to modulate the immune response". Trabalho apresentado em Gordon Research Conference on Cancer Nanotechnology, 2019.
  3. Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Colaço, Mariana; Panão Costa, João; Schmutz, Mélanie; et al. "Safe-by-design of chitosan nanoparticles: the role of immunotoxicological properties". Trabalho apresentado em SPI XLV Annual Meeting, 2019.
  4. Jesus, Sandra; Da Silva, Jessica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester Nanoparticle Immunotoxicological Profile". Trabalho apresentado em SPI XLV Annual Meeting, Coimbra, Portugal, 2019.
  5. Bernardi, Natália; Jesus, Sandra; Da Silva, Jessica; Soares, Edna; Borges, Olga. "Evaluation of immunotoxicological properties of PCL and PCL/glucan nanoparticles.". Trabalho apresentado em 2nd SPLC-CRS Young Scientists Meeting, Santiago de Compostela, Spain, 2019.
  6. Duarte, Alana; Marques, Ana Patrícia; Jesus, Sandra; Panão Costa, João; Soares, Edna; Colaço, Mariana; Borges, Olga. "Assessment of immunotoxicological features of chitosan nanoparticles.". Trabalho apresentado em 2nd SPLC-CRS Young Scientists Meeting, Santiago de Compostela, Spain, 2019.
  7. Colaço, Mariana; Marques, Ana Patrícia; Jesus, Sandra; Borges, Olga. "Nanosized Glucan Particles as a Delivery System for Curcumin: the effect of size on immunotoxicity". Trabalho apresentado em 2nd SPLC-CRS Young Scientists Meeting, Santiago de Compostela, Spain, 2019.
  8. Jesus, Sandra; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Chronic Hepatitis B (CHB) vaccine: Shedding light on the immunotoxicity of chitosan as a nano-delivery system". Trabalho apresentado em Cibb meeting 2019, 2019.
  9. Borges, Olga; Colaço, Mariana; Marques, Ana Patrícia. "Immunotoxicity of Glucan nanoparticles: the size matters". Trabalho apresentado em SLAP 2018 (XVI Latin-American Polymers symposium) XIV Iberoamerican polymer congress - Mar del Plata, Argentin, 2018.
  10. Soares, Edna; Groothuismink, A. Boonstra; Borges, Olga. "ß-glucan-based adjuvants for Hepatitis B vaccination: particulate design for prophylactic and therapeutic needs". Trabalho apresentado em World Vaccine Congress Europe 2018, Lisbon, Portugal, 2018.
  11. Jesus, Sandra; Borges, Olga; Marques, Ana Patrícia; Zinn, Manfred; Borchard, Gerrit; Som, Claudia; Perale, Giuseppe; et al. "Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions.". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  12. Duarte, Alana; Marques, Ana Patrícia; Jesus, Sandra; Colaço, Mariana; Borges, Olga. "Chitosan nanoparticles as drug delivery systems: focus on immunotoxicological features". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  13. Santos, Helena; Pereira de Almeida, Luís; Borges, Olga. "Immunotoxicity of Chitosan Salts and Nanoparticles". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  14. Colaço, Mariana; Jesus, Sandra; Marques, Ana Patrícia; Soares, Edna; Duarte, Alana; Borges, Olga. "Nanosized glucan particles as a delivery system for curcumin". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  15. Panão Costa, João; Jesus, Sandra; Soares, Edna; Borges, Olga. "Chitosan-based nanoparticles for gene delivery.". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  16. Nunes, Renata; Sousa, C.; Mendes, A. F.; Borges, Olga. "Glucan particles to liver-targeted delivery of curcumin". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  17. Soares, Edna; Cordeiro, R.; Faneca, H.; Borges, Olga. "Targeted polymeric nanoengineered HBsAg DNA vaccine.". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery 2018, 2018.
  18. Duarte, Alana; Marques, Ana Patrícia; Jesus, Sandra; Colaço, Mariana; Borges, Olga. "Evaluation of chitosan nanoparticles immunotoxicity.". Trabalho apresentado em Sociedade Portuguesa de Imunologia XLIV Annual Meeting – Lisbon, 2018.
  19. Colaço, Mariana; Marques, Ana Patrícia; Duarte, Alana; Jesus, Sandra; Soares, Edna; Borges, Olga. "Glucan nanoparticle immunotoxicity: size matters". Trabalho apresentado em Sociedade Portuguesa de Imunologia XLIV Annual Meeting – Lisbon. 2018., 2018.
  20. Soares, Edna; Jesus, Sandra; Cordeiro, R.; Groothuismink, A. Boonstra; Borges, Olga. "ß-glucan-based adjuvants for Hepatitis B vaccination: particulate design for prophylactic and therapeutic needs.". Trabalho apresentado em Sociedade Portuguesa de Imunologia XLIV Annual Meeting – Lisbon, 2018.
  21. Borges, Olga. "Hepatitis B antigen: adjuvant activity of PCL/chitosan particles characterized by mast cell activation, IFN and IL-17 production". Trabalho apresentado em 10th Vaccine Congress, Amsterdam, Holand, 2016.
  22. Jesus, Sandra; Soares, Edna; Borges, Olga. "Hepatitis B vaccine: chitosan-based delivery system for efficient HBsAg oral immunization". Trabalho apresentado em XI Spanish-Portuguese Conference on Controlled Drug Delivery, 2016.
  23. Jesus, Sandra; Adley, F. Rubira; Borchard, Gerrit; Muniz, Edvani C.; Valente, Artur J. M.; Borges, Olga. "Chitosan and PCL based nanoparticles as a delivery system for protein antigens on the nasal mucosa – characterization and in vitro experiments". Trabalho apresentado em 20th International Symposium on Surfactants in Solution, 2014.
  24. Jesus, Sandra; Soares, Edna; Borges, Olga. "Hepatitis B vaccine: chitosan-based delivery system for efficient HBsAg oral immunization". Trabalho apresentado em XL Annual Meeting of the Portuguese Society for Immunology, 2014.
  25. Jesus, Sandra; Soares, Edna; Borges, Olga. "PCL/chitosan NPs for nasal delivery of HBsAg presents immunostimulatory adjuvant effect in C57BL/6 mice". Trabalho apresentado em XL Annual Meeting of the Portuguese Society for Immunology, 2014.
  26. Jesus, Sandra; Soares, Edna; Borges, Olga. "PCL/chitosan NPs for nasal delivery of HBsAg presents immunostimulatory adjuvant effect in C57BL/6 mice". Trabalho apresentado em XL Annual Meeting of the Portuguese Society for Immunology, 2014.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/02 Imunotoxicological evaluation of chitosan nanoparticles SPF Meeting 2019
(Porto, Portugal)
2019/02 Curcumin-loaded Glucan Nanoparticles: Immunotoxicity Profile SPF Meeting 2019
(Porto, Portugal)
2019/02 Evaluation of the immunotoxicological properties in nanoparticles: PCL and PCL/Glucan SPF Meeting 2019
(Porto, Portugal)
2019/02 Endotoxin-free chitosan does not stimulate human PBMCs proinflammatory cytokine secretion SPF Meeting 2019
(Porto, Portugal)
2019/02 Immunotoxicity profile of PLA nanoparticles SPF Meeting 2019
(Porto, Portugal)
2019/01 Evaluation of the immunotoxicological properties of PLA nanoparticles 2nd SPLC-CRS Young Scientists Meeting
(Santiago de Compostela, Espanha)
2018/11 The role of the Immunopharmacological properties SLAP 2018 (XVI Latin-American Polymers symposium) XIV Iberoamerican polymer congress
(Mar del Plata, Argentina)
2018/09 Glucan-based particles: a new adjuvant for hepatitis B therapeutic vaccines 5th international conference on: Virus-like particle and nano-particle vaccines
(Berne, Suiça)
2018/09 Chitosan-based delivery systems with vaccine application 9th EDCTP Forum
(Lisbon, Portugal)
2018/07 Chitosan-based Nanoparticles as Emerging Adjuvants for a Hepatitis B Therapeutic 7th Annual World Congress of Infectious Diseases (WCID-2018)
(Bangkok, Tailândia)
2018/06 Chitosan/ß-glucan particles for hepatitis B surface antigen vaccination: prophylactic and therapeutic value IV SPCAL Congress, Quality and Transparency in Science Involving Laboratory Animals
(Braga, Portugal)
2018/02 Chitosan and ß-glucan particulate adjuvants for hepatitis B prophylactic and therapeutic needs. SPF Meeting 2018
(Lisbon, Portugal)
2017/04 Yeast-derived glucan particles prophylactic and therapeutic value for hepatitis B 1st SPLC-CRS Young Scientist Meeting
(Santiago de Compostela, Espanha)
2017/03 Vacina nasal: fator dissuasor no bioterrorismo com antraz III ENEBT – Encontro Nacional de Estudantes de Biotecnologia
(Aveiro, Portugal)
2016/11 Vacinação nasal para o antraz:uma ferramenta contra o bioterrorismo? Congresso Científico AEFFUP
(Porto, Portugal)
2016/09 Hepatitis B vaccine: chitosan or glucan-based Delivery system for efficient HBsAg oral immunization 10th Vaccine Congress
(Amsterdam, Países Baixos)
2016/01 PCL/Chitosan nanoparticle adjuvante ability for HBsAg vacines XI Spanish-Portuguese Conference on Controlled Drug Delivery.
(Granada, Espanha)
2015/12 Adjuvant nanocarriers for hepatitis B vaccine XIII Annual Meeting – Center for Neuroscience and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine
(Coimbra, Portugal)
2014/06 Chitosan and PCL based nanoparticles as a delivery system for protein antigens on the nasal mucosa – characterization and in vitro experiments 20th International Symposium on Surfactants in Solutions (SIS)
(Coimbra, Portugal)
2012/11 Potential of Chitosan/Poly-epsilon caprolactone Nanoparticles for protein and DNA nasal delivery 17th Rencontre Pharmapeptides
(Archamps, França)
2011 Association of different immunopotentiators as promising mucosal adjuvants in future. 4th international conference on immunopotentiators in modern vaccines.
(Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022 - Atual Development of an oral vaccine for companion animals based on Giardia Extracellular Vesicles
Coorientador
Doutoramento (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - Atual Designing chitosan-based nanoparticles for nasal immunization against SARS-CoV2
Orientador
doutoramento (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - Atual Development of a therapeutic hepatitis B vaccine: designing a prototypic particulate-based multicomponent for immune modulation
Orientador
Doutoramento (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022 - 2023 Curcumin-loaded lactobionic acid modiefied chitosan-nanoparticles for hepatic cancer therapy
Orientador
Mestrado em Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 - 2023 Exploring The Immunomodulatory Potential of Toll-like Receptor Agonists Encapsulated within Glucan Particles as Vaccine Adjuvants
Orientador
mestrado (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022 - 2023 The immunomodulatory effect of the roots of Withania Somnifera encapsulated into ß-glucan particles
Orientador
Mestrado em Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2022 Gene therapy mediated by glycopolymers-based nanocarriers in combination with chemotherapeutic drugs as a potential therapeutic strategy for hepatocellular carcinoma
Coorientador
doutoramento (Doutoramento)
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2020 - 2021/12/06 The impact of curcumin-encapsulated glucan nanoparticles on hepatic cells and immune cells: oxidative stress and immunomodulatory properties”
Orientador
Mestrado em Biotecnologia Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2021/12/03 INULIN PARTICLES AS A VACCINE ADJUVANT FOR HEPATITIS B. DEVELOPMENT AND IN VITRO EVALUATION OF THEIR IMMUNOTOXICITY
Orientador
Mestrado em Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2019 Avaliação das propriedades imunotoxicologicas das nanopartículas de PCL e PCL/Glucano
Orientador de Bernardi, Natalia Sozza
University of Coimbra - Faculty of Pharmacy, Portugal
2016 - 2018 Development of nanosized glucan particles with immunostimulatory function as a delivery syistem for curcumin
Orientador
University of Coimbra - Faculty of Pharmacy, Portugal
2016 - 2018 Immunocytotoxicity of Chitosan Nanoparticles: Effect of Chitosan Deacetylation Degree
Orientador
University of Coimbra - Faculty of Pharmacy, Portugal
2016 - 2018 Avaliação das propriedades imunotoxicológicas de nanopartículas de PLA
Orientador de Silva, Jéssica Gonçalves Da
University of Coimbra - Faculty of Pharmacy, Portugal
2014 - 2018 Beta-Glucan-based adjuvants for hepatits B vaccination: Particulate Design for prophylactic and therapeutic needs.
Orientador de SOARES, Edna Filipa Pais Soares
University of Coimbra - Faculty of Pharmacy, Portugal
2011 - 2017/11/25 Development of chitosan-based nanoparticles for nasal immunization against hepatitis B.
Orientador de LEBRE, Filipa Raquel Maia Fontes
2011 - 2017/02/09 Association of compound 48/80 with chitosan based nanoparticles : designing a novel prototypic delivery system for nasal vaccination.
Orientador de BENTO, Dulce Marisa Ferreira
University of Coimbra - Faculty of Pharmacy, Portugal
2016 - 2017 Desenvolvimento de nanoparticulas e investigação do mecanismo de ação envolvido na morte celular de Leishmania sp induzida pela substância sugiol
Coorientador
doutoramento (Doutoramento)
Editora da Universidade Estadual de Maringá, Brasil
2016 - 2017 AVALIAÇÃO BIOLÓGICA E ELUCIDAÇÃO DO MECANISMO DE AÇÃO DO COMPOSTO SINTÉTICO 4-[(2E)-N’-(2,2’-BITIENIL-5-METILENO)HIDRAZINACARBONIL]-6,7-DIIDRO-1-FENIL-1H-PIRAZOLO[3,4-d]PIRIDAZIN-7-ONA SOBRE Leishmania sp.
Coorientador
doutoramento (Doutoramento)
Editora da Universidade Estadual de Maringá, Brasil
2015 - 2017 Nanotechnology & nanovaccines: nanoparticles internalization pathways and cross – presentation
Orientador de Coelho, David José Caetano
Mestrado em Bioquímica (Mestrado)
2012 - 2016/02/18 Adjuvant nanocarriers for hepatitis b vaccine : formulation design and mechanistic studies.
Orientador de JESUS, Sandra Cristina Campus de
University of Coimbra - Faculty of Pharmacy, Portugal
2013 - 2015 Desenvolvimento de uma vacina oral contra Giardia Lamblia
Orientador de Pica-Milho, Ana Cláudia Falcão
University of Coimbra - Faculty of Pharmacy, Portugal

Membro de associação

Nome da associação Tipo de participação
2010 - Atual Sociedade Portuguesa de Imunologia
2005 - Atual Controlled release society membership membership
1992 - Atual Ordem dos Farmacêuticos Portugueses member
2015 - 2016 International Society for Vaccines
2012 - 2013 American Association of Pharmaceutical Scientists, member
Distinções

Outra distinção

2004 “Best podium presentation”