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I am a population geneticist interested in the mechanistic processes of Evolution and in establishing cross-disciplinary dialogues to understand the human past. I work across a wide range of topics at the forefront of evolutionary genetics, including demographic inference, comparative genomics, conservation genetics and natural selection, using both modern and ancient DNA. I am particularly interested in human evolution and the admixture events between human groups in the Pleistocene, historical human migrations in Europe and the Americas, the dynamics of domestication and the impacts of these processes for human health. I am deeply committed to interdisciplinary research and in combining genetics with other disciplines, in particular archaeology and philosophy, to establish new research paradigms and build holistic perspectives of human history. At present, I hold a Discovery Early Career Researcher Award from the Australian Research Council that allows me to develop my research at the Australian National University, in Canberra; and serve as elected Scientific Vice-Coordinator of the Centre for Interdisciplinary Studies of the University of Coimbra (CEIS20).
Identificação

Identificação pessoal

Nome completo
João Carlos Aguiar Macedo Teixeira

Nomes de citação

  • Teixeira, João
  • Teixeira, JC
  • João C. Teixeira

Identificadores de autor

Ciência ID
BE1B-2E3D-78D5
ORCID iD
0000-0001-6417-4702

Endereços de correio eletrónico

  • joao.teixeira@anu.edu.au (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade
  • Ciências Naturais - Ciências Biológicas - Biologia da Evolução das Espécies
  • Ciências Naturais - Ciências Biológicas
  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2016
Concluído
Evolutionary Genetics (Doctor of Philosophy)
Max-Planck-Institut für evolutionäre Anthropologie, Alemanha
"Long-term balancing selection in the genomes of humans and other great apes" (TESE/DISSERTAÇÃO)
2011
Concluído
Genética Forense (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Phylogeographic analysis of maternal lineages in the Portuguese Jewish community" (TESE/DISSERTAÇÃO)
2009
Concluído
Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2022 - Atual Investigador (Investigação) The Australian National University, Austrália
2018/02/19 - 2021 Investigador (Investigação) The University of Adelaide, Austrália
2016/05/02 - 2017/07/31 Pós-doutorado (Investigação) Institut Pasteur, França

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2022/11 - Atual Subdirector de Unidade Orgânica Universidade de Coimbra Centro de Estudos Interdisciplinares do Século XX, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03/01 - Atual Encounters with hominins: the history of human arrival in Sahul
Investigador responsável
The Australian National University, Austrália
Australian Research Council
Em curso
2016/05/02 - 2017/07/31 Comparative genomics of innate immunity in humans and non-human primates
LABEX IBEID
Bolseiro de Pós-Doutoramento
Institut Pasteur, França

Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases, França
Institut Pasteur
2012/01/01 - 2015/12/31 Long-term balancing selection in the genomes of humans and other great apes
SFRH/BD/77043/2011
Bolseiro de Doutoramento
Max-Planck-Institut für evolutionäre Anthropologie, Alemanha
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. João C. Teixeira. "The immunogenetic impact of European colonization in the Americas". Frontiers in Genetics 13 (2022): http://dx.doi.org/10.3389/fgene.2022.918227.
    10.3389/fgene.2022.918227
  2. João C. Teixeira. "A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics". The Lancet 400 10353 (2022): 691-692. http://dx.doi.org/10.1016/s0140-6736(22)01476-3.
    10.1016/s0140-6736(22)01476-3
  3. Teixeira, JC. "Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology". Conservation Genetics 22 4 (2021): 547-549. http://dx.doi.org/10.1007/s10592-021-01385-8.
    10.1007/s10592-021-01385-8
  4. Gludhug Ariyo Purnomo; Kieren J Mitchell; Sue O'Connor; Shimona Kealy; Leonard Taufik; Sophie Schiller; Adam Rohrlach; et al. "Mitogenomes Reveal Two Major Influxes of Papuan Ancestry across Wallacea Following the Last Glacial Maximum and Austronesian Contact". Genes (2021): https://www.mdpi.com/2073-4425/12/7/965.
    10.3390/genes12070965
  5. João C. Teixeira; Guy S. Jacobs; Chris Stringer; Jonathan Tuke; Georgi Hudjashov; Gludhug A. Purnomo; Herawati Sudoyo; et al. "Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture". Nature Ecology & Evolution (2021): https://doi.org/10.1038/s41559-021-01408-0.
    10.1038/s41559-021-01408-0
  6. Teixeira, JC. "Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America.". iScience (2021): https://europepmc.org/articles/PMC8188552.
    10.1016/j.isci.2021.102553
  7. João C. Teixeira; Christian D. Huber. "The inflated significance of neutral genetic diversity in conservation genetics". Proceedings of the National Academy of Sciences (2021): https://doi.org/10.1073/pnas.2015096118.
    10.1073/pnas.2015096118
  8. Roca-Rada, Xavier; Souilmi, Yassine; Teixeira, João C.; Llamas, Bastien. "Ancient DNA Studies in Pre-Columbian Mesoamerica". Genes 11 11 (2020): 1346. http://dx.doi.org/10.3390/genes11111346.
    10.3390/genes11111346
  9. Teixeira, JC. "Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide.". Hla (2020): https://europepmc.org/articles/PMC7300650.
    10.1111/tan.13956
  10. Williams, Matthew; Teixeira, João. "A genetic perspective on human origins". The Biochemist 42 1 (2020): 6-10. http://dx.doi.org/10.1042/bio04201006.
    10.1042/bio04201006
  11. O’Neill, Mary B; Laval, Guillaume; Teixeira, João C; Palmenberg, Ann C; Pepperell, Caitlin S. "Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150¿000 years". Human Molecular Genetics 29 5 (2019): 736-744. http://dx.doi.org/10.1093/hmg/ddz304.
    10.1093/hmg/ddz304
  12. João C. Teixeira; Alan Cooper. "Using hominin introgression to trace modern human dispersals". Proceedings of the National Academy of Sciences 116 31 (2019): 15327-15332. https://doi.org/10.1073/pnas.1904824116.
    10.1073/pnas.1904824116
  13. Bitarello, Bárbara D; de Filippo, Cesare; Teixeira, João C; Schmidt, Joshua M; Kleinert, Philip; Meyer, Diogo; Andrés, Aida M. "Signatures of Long-Term Balancing Selection in Human Genomes". Genome Biology and Evolution 10 3 (2018): 939-955. http://dx.doi.org/10.1093/gbe/evy054.
    10.1093/gbe/evy054
  14. Teixeira, João C.; de Filippo, Cesare; Weihmann, Antje; Meneu, Juan R.; Racimo, Fernando; Dannemann, Michael; Nickel, Birgit; et al. "Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos". Molecular Biology and Evolution 32 5 (2015): 1186-1196. http://dx.doi.org/10.1093/molbev/msv007.
    10.1093/molbev/msv007
  15. Nogueiro, Inês; Teixeira, João C.; Amorim, António; Gusmão, Leonor; Alvarez, Luis. "Portuguese crypto-Jews: the genetic heritage of a complex history". Frontiers in Genetics 6 (2015): http://dx.doi.org/10.3389/fgene.2015.00012.
    10.3389/fgene.2015.00012
  16. Key, Felix M; Teixeira, João C; de Filippo, Cesare; Andrés, Aida M. "Advantageous diversity maintained by balancing selection in humans". Current Opinion in Genetics & Development 29 (2014): 45-51. http://dx.doi.org/10.1016/j.gde.2014.08.001.
    10.1016/j.gde.2014.08.001
  17. Nogueiro, Inês; Teixeira, João; Amorim, António; Gusmão, Leonor; Alvarez, Luis. "Reply to letter from Felice L. Bedford and Doron Yacobi". European Journal of Human Genetics 23 8 (2014): 994-995. http://dx.doi.org/10.1038/ejhg.2014.232.
    10.1038/ejhg.2014.232
  18. Nogueiro, Inês; Teixeira, João; Amorim, António; Gusmão, Leonor; Alvarez, Luis. "Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants". European Journal of Human Genetics 23 5 (2014): 693-699. http://dx.doi.org/10.1038/ejhg.2014.140.
    10.1038/ejhg.2014.140
  19. Teixeira, J.C.; Nogueiro, I.; Goios, A.; Gusmão, L.; Amorim, A.; Alvarez, L.. "Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community". Forensic Science International: Genetics Supplement Series 3 1 (2011): e51-e52. http://dx.doi.org/10.1016/j.fsigss.2011.08.025.
    10.1016/j.fsigss.2011.08.025
Poster em conferência
  1. Teixeira, João. "Balancing selection in the great apes". Trabalho apresentado em Cold Spring Harbour Biology of Genomes, 2015.
  2. Teixeira, JC. "Long-term balancing selection in LAD1 maintains a missense trans-species polymorphism in humans, chimpanzees and bonobos". Trabalho apresentado em SMBE 2014, 2014.
  3. Teixeira, JC. "Long-term balancing selection has influenced protein evolution in humans, chimpanzees and bonobos". Trabalho apresentado em SMBE 2013, 2013.
  4. Teixeira, JC. "Patterns of shared polymorphism in humans and apes". Trabalho apresentado em SMBE 2012, 2012.
  5. Teixeira, JC. "Phylogeographic analysis of maternal lineages in the NE Portuguese Jewish community". Trabalho apresentado em Portugaliae Genetica, 2011.
Tese / Dissertação
  1. Teixeira, João. "Long-term balancing selection in the genomes of humans and other great apes". Doutoramento, 2016. https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-158592.

Outros

Outra produção
  1. Ancient human genomes reveal a hidden history of strong selection in Eurasia. 2020. Yassine Souilmi; Raymond Tobler; Angad Johar; Matthew Williams; Shane T. Grey; Joshua Schmidt; João C. Teixeira; et al. https://doi.org/10.1101/2020.04.01.021006.
    10.1101/2020.04.01.021006
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 Introgression, hominin dispersal and megafaunal survival in Late Pleistocene Island Southeast Asia
University of Plymouth (Reino Unido)
2021 Hominin introgression in Island Southeast Asia
Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Portugal)
2021 Searching for our origins: genetics and human evolution
Universidade do Porto (Portugal)
2020 Hominid Population Genetics
Max Planck Institute for Evolutionary Anthropology (Alemanha)
2019 Using DNA to reconstruct the history of Sahul International Conference on the History of Language
The Australian National University (Canberra, Austrália)
2019 Archaic introgression and the modern human colonization of Australia
Eijkman Institute for Molecular Biology (Indonésia)
2018 The Aboriginal Heritage Project International Symposium on Biomolecular Archaeology
(Jena, Alemanha)
2016 Comparative genomics of innate immunity in human and non-human primates The Meeting of the American Society of Human Genetics
(Vancouver, Canadá)
2015 Long-term balancing selection in great apes II BioAnthropological Meeting – Life, Death and in Between
Universidade de Coimbra (Coimbra, Portugal)
Distinções

Prémio

2021 School of Biological Sciences Publication Excellence Award Winner
The University of Adelaide, Austrália
2017 ASHG/Charles J. Epstein Trainee Award for Excellence in Human Genetics Research (semi-finalist)
American Society of Human Genetics, Estados Unidos
2013 Graduate Student Travel Award Society for Molecular Biology and Evolution
2010 Prémio Escolar António Leitão
Universidade do Porto Faculdade de Ciências, Portugal