???global.info.a_carregar???
Tânia Morais is an junior researcher at Centro de Química Estrutural of Faculdade de Ciências da Universidade de Lisboa (CQE-FCUL). She obtained her degree in Chemistry (2007) by Faculdade de Ciências da Universidade de Lisboa (FCUL), where she also completed a master's degree in Chemistry with specialization in Chemistry, Health and Nutrition (2008). Tânia Morais got her PhD in Chemistry with specialization in Inorganic Chemistry (2013) by University of Lisbon developing ruthenium organometallic compounds for cancer therapy. In 2013 she start a postdoc at Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, where she develops peptide-metal conjugates for targeted therapy. In 2014 she was honored by the Portuguese Chemical Society with the prize "Portuguese Young Chemist Award". In 2015, Tânia was a visitor postdoc researcher at Barcelona Biomedical Research Park (PRBB), Barcelona, Spain under a Marie Sklodowska-Curie project, that allow her to acquire important know-how in peptide synthesis. In 2019, Tânia won a contract in the frame of CEEC Individual 2017 program and started an independent research at CQE-FCUL where she develops metal-peptide conjugates for targeted therapy, merging her know-how in organometallic chemistry with her expertise in peptide chemistry. Tânia research focuses in the design, synthesis and characterization of Ru, Fe and Cu complexes with targeting molecules (e.g. peptides, carbohydrates, biomolecules) in their structure for the selective inhibition of the cancer development and metastases. Tânia Morais is co-founder of a FCUL proto-company named "HATIcancer". Tânia is currently Principal Investigator of one research projects funded by the Portuguese Foundation for Science and Technology (FCT) and she also participates on the Transnational Cooperation Programme - Portugal-Hungary, ¿Development and bio-speciation studies of antitumor ruthenium complexes¿. Tânia has experience as a scientific adviser (PhD Supervision: 1 (since 2018, ongoing); Master Supervision: 4 (since 2015); Graduation Thesis Supervision: 9 (1 ongoing); Erasmus - graduation students: 2). She is currently a lecturer of the practical course of inorganic complementary chemistry (BSc in chemistry) and a lecturer Inorganic Biochemistry (BSc in Biochemistry). Tânia has so far authored 28 articles published in international journals with peer review (6 as senior corresponding author), 6 book chapters, several conference proceedings and 4 inter-/national patents with over 607 citations and has a H-index of 16.
Read full resume ↓
Identification

Personal identification

Full name
Tânia Sofia Ferreira Morais
Gender
Female

Citation names

  • Tânia S. Morais
  • T. S. Morais
  • Morais, Tânia S.
  • Morais, T. S.

Author identifiers

Ciência ID
B61A-A9D4-08CC
ORCID iD
0000-0003-0233-8243
Google Scholar ID
https://scholar.google.pt/citations?user=mp1D9D4AAAAJ&hl=pt-PT&oi=ao
Researcher Id
D-8824-2011
Scopus Author Id
25930490800

Email addresses

  • tsmorais@fc.ul.pt (Professional)

Telephones

Telephone
  • 217500954 (Professional)

Addresses

  • Centro de Química Estrutural (CQE@ciências) Faculdade de Ciências da Universidade de Lisboa, Campo Grande, Ed. C8, 1749-016, Lisboa, Lisboa, Portugal (Professional)

Websites

  • https://cqe.tecnico.ulisboa.pt/members/556 (Scholar)
  • https://ciencias.ulisboa.pt/pt/perfil/tsmorais (Scholar)
  • https://www.arrows2cancer.com/ (Professional)
  • https://publons.com/researcher/1604867/tania-s-morais/ (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Elementary (A2) Advanced (C1) Elementary (A2)
Education
Degree Classification
2013/12/11
Concluded
 Química (Doutoramento)
Major in Química Inorgânica/Inorganic chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Evaluation of the potential anti-tumoral properties of new ruthenium bioorganometallic compounds" (THESIS/DISSERTATION)
 20-Aproved by unanimity (summa cun laude)
2008/07
Concluded
 Química (Mestrado)
Major in Química, Saúde e Nutrição /Chemistry, health and nutrition
Universidade de Lisboa Faculdade de Ciências, Portugal
"Synthesis and characterization of cytotoxic organometallic complexes derived from “RuCp” fragment and evaluation of their potential as antitumor agents " (THESIS/DISSERTATION)
 17
2007/09
Concluded
 Química (Licenciatura)
Major in n/a
Universidade de Lisboa Faculdade de Ciências, Portugal
"Synthesis and characterization of Ru(II) and Fe(II) complexes with nitrogenous ligands. Preliminary study on their potential as antitumor agents" (THESIS/DISSERTATION)
 15
Affiliation

Science

2019/05/01 - Current Contracted Researcher (Research)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/08/01 - 2019/04/30 Postdoc (Research)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/03/01 - 2016/07/31 Postdoc (Research)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/04/01 - 2015/10/31 Visiting Researcher (Research)
Universitat Pompeu Fabra, Spain

Teaching in Higher Education

2019 - Current Assistant Professor (University Teacher)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2018 Invited Assistant Professor (University Teacher)
Universidade de Lisboa, Portugal
2013 - 2016 Assistant Professor (University Teacher)
Universidade de Lisboa Faculdade de Ciências, Portugal

Positions / Appointments

2020/07 - Current Co-coordinator of the 1st cycle Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07 - Current Member of the Pedagogic Committee of the 1st Cycle in Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

2017/01/22 - Current Co-founder of HATICancer Proto-Company
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/12/01 - 2014/02/28 Research Fellow under the project "Preclinical evaluation of ruthenium potential drugs for cancer therapy", FCT PTDC/QUI-QUI/118077/2010
Universidade de Lisboa Faculdade de Ciências, Portugal
2009/11/01 - 2013/10/31 PhD. Student with Fundação para a Ciência e Tecnologia (FCT) grant: SFRH/BD/ 45871/2008 "Evaluation of the potential anti-tumoral properties of new ruthenium bioorganometallic compounds";
Universidade de Lisboa Faculdade de Ciências, Portugal
2009/05/01 - 2009/10/31 Research Fellow under the project "Synthesis of molecular and polymeric organometallic materials with non-linear optical properties", FCT PTDC/QUI/66148/2006
Universidade de Lisboa Faculdade de Ciências, Portugal
2008/05/01 - 2009/04/30 Research Fellow under the project "Design of copper, zinc or iron compounds with leishmanicidal activity", FCT PTDC/QUI/72656/2006
Universidade de Lisboa Faculdade de Ciências, Portugal
2007/10/01 - 2008/04/30 Research in the frame of the M.Sc. thesis in Chemistry: Chemistry, health and nutrition
Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2018 - Current Targeting metastatic breast cancer with innovative ruthenium-peptide conjugates
SFRH/BD/135915/2018
Supervisor
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
2014 - 2019/04/30 Targeting tumors with innovative metal peptide complexes: improving efficacy in anticancer drugs
SFRH/BPD/93513/2013
Post-doc Fellow
Universidade de Lisboa Centro de Química Estrutural, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
2009 - 2013/10/31 EVALUATION OF THE POTENTIAL ANTI-TUMORAL PROPERTIES OF NEW RUTHENIUM BIOORGANOMETALLIC COMPOUNDS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F458712%F2008/PT
PhD Student Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia

Contract

Designation Funders
2019 - Current Ruthenium-peptide drugs: new bullets to fight breast cancer; CEECIND2017 - Stimulus of Scientific Employment -Individual Support 2017 - FCT Programme
CEECIND/00630/2017
Principal investigator
Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
2021 - 2024/02/29 Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/0146/2020
Principal investigator
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
2015 - 2015/10/31 Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training, and communication
INPACT Grant Agreement: 644167
Researcher
Instituto de Medicina Molecular, Portugal
 EU Framework Programme for Research and Innovation Euratom
2013 - 2014/02/28 Preclinical evaluation of ruthenium potential drugs for cancer therapy
PTDC/QUI-QUI/118077/2010
Research Fellow
Fundação para a Ciência e a Tecnologia
2010 - 2013 Ruthenium complexes for anti-tumour applications
PTDC/QUI-QUI/101187/2007
Researcher
Fundação para a Ciência e a Tecnologia
2009 - 2009/10/31 Synthesis of molecular and polymeric organometallic materials with non-linear optical properties
PTDC/QUI/66148/2006
Research Fellow
Fundação para a Ciência e a Tecnologia
2008 - 2009/04/30 Design of copper, zinc or iron compounds with leishmanicidal activity
PTDC/QUI/72656/2006
Research Fellow
Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2019 - 2021/05/31 Development and bio-speciation studies of ruthenium anti-tumor complexes _Scientific and Technological Cooperation Project - Portugal-Hungary
FCT/NKFIH, 2019/2020
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2017 Complexes of Flavonoid's Schiff bases: Impact of structural modification on the chelating ability and evaluation of biological and therapeutic properties_Transnational Cooperation Programme - Portugal-Poland
FCT RD0480/Project 6818
Researcher
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Andreia Valente; Tânia S. Morais; Ricardo G. Teixeira; Cristina P. Matos; Ana Isabel Tomaz; M. Helena Garcia. "Ruthenium and iron metallodrugs: new inorganic and organometallic complexes as prospective anticancer agents". In Synthetic Inorganic Chemistry New Perspectives. Elsevier, 2021.
    Published
  2. Andreia Valente; Tânia S. Morais; Maria Helena Garcia. "Ruténio - o elemento que não para de nos surpreender!". In Os Elementos em Ciências - Uma viagem pela Tabela Periódica (printed version & EPub), edited by Ana Mourato; Ana Paula Carvalho; Filomena Leitão; Teresa Pamplona. Lisbon, Portugal: Faculdade de Ciências da Universidade de Lisboa, 2020.
    Published
  3. Tânia S. Morais; Maria José Villa de Brito. "O cobre "potagonista de todos os tempos"". In Os Elementos em Ciências - Uma viagem pela Tabela Periódica (printed version & EPub), edited by Ana Mourato; Ana Paula Carvalho; Filomena Leitão; Teresa Pamplona. Lisbon, Portugal: Faculdade de Ciências da Universidade de Lisboa, 2020.
    Published
  4. Matos, António; Mendes, Filipa; Valente, Andreia; Morais, Tânia S.; Tomaz, Ana Isabel; Zinck, Philippe; Garcia, Maria Helena; Bicho, Manuel; Marques, Fernanda. "Ruthenium-Based Anticancer Compounds: Insights into Their Cellular Targeting and Mechanism of Action". In Ruthenium Complexes: Photochemical and Biomedical Applications, edited by Alvin A. Holder; Lothar Lilge; Wesley R. Browne; Mark A.W. Lawrence; Jimmie L. Bullock Jr., 201-219. Wiley-VCH Verlag GmbH & Co. KGaA, 2018.
    Published • 10.1002/9783527695225.ch10
  5. Tiago J. Silva; Paulo J. Mendes; Tânia S. Morais; Andreia Valente; M. Paula Robalo; M. Helena Garcia. ""RuCp" a versatile moiety: From NLO to antitumor properties". In Ruthenium: Synthesis, Physicochemical Properties and Applications, edited by Gary P. Keeler, 105-164. Nova Science Publishers, Inc., 2014.
    Published
  6. Tânia S. Morais; Maria Helena Garcia. "On the Track to Cancer Therapy: Paving New Ways with Ruthenium Organometallics". In Advances in Organometallic Chemistry and Catalysis: The Silver / Gold Jubilee International Conference on Organometallic Chemistry Celebratory Book, edited by Armando J. L. Pombeiro, 581-588. Wiley, 2013.
    Published • 10.1002/9781118742952.ch43
Conference paper
  1. Fernanda Marques; Sílvia A. Sousa; Jorge H. Leitão; Tânia S. Morais; Yann Le Gal; Dominique Lorcy. "Gold(III) biddithiolate complexes: molecular conductors that also exhibit antitumor and antimicrobial activities". Paper presented in 4th International Congress of CiiEM 2019 on Health, Well-Being and Ageing in the 21st Century, 2019.
    Published
  2. Maria Helena Garcia; Andreia Valente; Tânia S. Morais; Ana Isabel Tomaz. "Ruthenium new drug: paving the way for cancer therapy". Paper presented in 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis, 2017.
    Published • doi.org/10.1007/s00775-017-1475-y
  3. Maria Helena Garcia; Andreia Valente; Tânia S. Morais; Fernanda Marques. "Ruthenium Organometallic compounds as promising antimetastatic drugs for breast cancer chemotherapy". Paper presented in European Chemistry Congress, Rome, 2016.
    Published • 10.4172/21503494.C1.002
  4. Maria Helena Garcia; Tânia S. Morais; Fernanda Marques; Andreia Valente. "Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances". Paper presented in 4th International Conference on Medicinal Chemistry and Computer Aided Drug Designing, Atlanta, 2015.
    Published • 10.4172/21610444.C1.015
  5. Maria Helena Garcia; Tânia S. Morais; Andreia Valente; Fernanda Marques. "Tracking antitumor drugs: Ruthenium(II)cyclopentadienyl complexes as promising agents". Paper presented in 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing, San Francisco, 2014.
    Published • 10.4172/21610444.S1.011
  6. Fernanda Marques; Leonor Côrte-Real; António P. Matos; Tânia S. Morais; Irina Alho; Ana Isabel Tomaz; Maria Helena Garcia; Manuel P. Bicho. "Intracellular distribution of antitumor Ru(II) compounds: the lysosome and the lysosomal enzymes as targets for anticancer metal based Drugs". Paper presented in XLVI Congress of the Portuguese Society for Microscopy 2012, Lisbon, 2012.
    Published • 10.1017/S1431927613000664
  7. Tânia S. Morais; Maria Helena Garcia; M. Paula Robalo; Andreia Valente; Virtudes Moreno; Mercè Font-Bardia; Teresa Calvet; Julia Lorenzo; Francesc X. Avilés. "Cytotoxicity Studies and DNA Interaction of New Ruthenium(II) Cyclopentadienyl Complexes with Nitrogen Coordinated Ligands". Paper presented in XII Iberian Meeting of Electrochemistry and XVI Meeting of the Portuguese Electrochemical Society, Lisbon, 2010.
    Published
Conference poster
  1. João Franco Machado; Miguel Machuqueiro; Fernanda Marques; M. Paula Robalo; M. Fátima M. Piedade; M. Helena Garcia; João D. G. Correia; Tânia S. Morais. "Ru-peptide conjugates for targeting metastatic breast cancer". Paper presented in 2nd CQE Days Spring Meeting (Virtual), 2020.
  2. Andreia Valente; Tânia S. Morais; Leonor Côrte-Real; Ana Isabel Tomaz; M. José Brito; M. Helena Garcia. "Metallodrugs for cancer therapy: challenges and expectations". Paper presented in Ciências Research Day, Lisbon, Portugal, 2019.
  3. João Franco Machado; Margarida P. Pereira; M. Paula Robalo; M. Fátima M. Piedade; M. Helena Garcia; Tânia S. Morais. "New ruthenium(II)-cyclopentadienyl complexes for cancer therapy: synthesis, characterisation and interaction with human serum albumin". Paper presented in 4Th Meeting of the College of Chemistry (4ECQUL) - Chemistry: Shaping The Future, 2019.
  4. Fernanda Marques; Sílvia A. Sousa; Jorge H. Leitão; Tânia S. Morais; Yann Le Gal; Dominique Lorcy. "Gold(III) dithiolate complexes: molecular conductors that also exhibit antitumor and antimicrobial activities". Paper presented in 4th International Congress of CiiEM 2019 on Health, Well-Being and Ageing in the 21st Century, Caparica, Portugal., 2019.
  5. Margarida P. Pereira; João Franco Machado; M. Fátima M. Piedade; M. Helena Garcia; Tânia S. Morais. "Synthesis and characterization of a new family of ruthenium(II) complexes with phenantroline derivated ligands for anticancer applications". Paper presented in 1st CQE Days – Spring Meeting 2019, 2019.
  6. João Franco Machado; Fernanda Marques; M. Fátima M. Piedade; Maria J. Villa de Brito; M. Helena Garcia; Tânia S. Morais. "New selective Copper(I) complexes for prostate cancer cells". Paper presented in 1st CQE Days – Spring Meeting 2019, Lisbon, Portugal, 2019.
  7. Tânia S. Morais; Catarina Bravo; João Franco Machado; Nuno Xavier; M. José Villa de Brito; M. Helena Garcia. "Synthesis and characterization of new copper(I) complexes comprising carbohydrates for cancer therapy". Paper presented in 29th International Carbohydrate Symposium (ICS2018), Lisbon, Portugal, 2018.
  8. João Franco Machado; Inês D. Ribeiro; Maria José Villa de Brito; M. Fátima M. Piedade; Maria Helena Garcia; Tânia S. Morais. "Synthesis and structural characterisation of a new family of copper(I)-phosphane complexes for cancer therapy". Paper presented in 3rd Meeting of the College of Chemistry (3ECQUL), Lisbon, Portugal, 2018.
  9. Catarina Bravo; M. Paula Robalo; Fernanda Marques; M. Fátima Minas da Piedade; Maria Helena Garcia; Maria José Villa de Brito; Tânia S. Morais. "Heterobimetallic Cu(I)-Fe(II) complexes with NN-, NO-, NS- heteroaromatic ligands for cancer therapy: a combined structural, electrochemical and biological study". Paper presented in 3rd Meeting of the College of Chemistry (3ECQUL), Lisbon, Portugal, 2018.
  10. Maria Helena Garcia; Andreia Valente; Tânia S. Morais; Ana Isabel Tomaz. "Ruthenium new drug: paving the way for cancer therapy". Paper presented in ICBIC18- 18th International Conference on Biological Inorganic Chemistry, Florianopólis, Brazil, 2017.
  11. Filipa D. de Oliveira; João Freire; M. Paula Robalo; M. Fátima M. Piedade; David Andreu; Ana Salomé Veiga; M. Helena Garcia; et al. "Study of cell penetrating peptides as drug delivery systems for chemotherapeutic drugs and their anticancer properties". Paper presented in A Química na Investigação da ULisboa – 1º Encontro do Colégio de Química (1ECQUL), Lisbon, Portugal, 2017.
  12. Miguel Freitas; Tânia S. Morais; Nuno Xavier; M. Helena Garcia. "New Ruthenium(II) Complexes Comprising Carbohydrates for cancer therapy: Synthesis and characterization". Paper presented in ChemBioChem, Lisbon, Portugal, 2017.
  13. António P. Matos; Lurdes Gano; Francisco Tortosa; Teresa Pinheiro; Tânia S. Morais; Andreia Valente; Ana Isabel Tomaz; Maria Helena Garcia; Fernanda Marques. "Microscopic Analysis of the Antitumor Effects of Ruthenium Complexes in a Prostate Cancer Model". Paper presented in Congresso Internacional From Basic Sciences to Clinical Research (First International Congress of CiiEM), Almada, Portugal., 2015.
  14. Ana Cristina Poeta; A. Sofia Assis; Andreia Valente; Tânia S. Morais; Fernanda Marques; M. Paula Robalo; Susana Santos; Ana Isabel Tomaz; M. Helena Garcia. "On the field of metallodrugs: novel ruthenium(II) complexes with thiosemicarbazones". Paper presented in 19th European Symposium on Organic Chemistry (ESOC2015), Lisbon, Portugal, 2015.
  15. Miguel de Freitas; Tânia S. Morais; Nuno M. Xavier; Maria Helena Garcia. "Synthesis of new ruthenium cyclopentadienyl complexes comprising carbohydrate ligands as potential antitumor agents". Paper presented in 19th European Symposium on Organic Chemistry (ESOC2015), Lisbon, Portugal, 2015.
  16. Fernanda Marques; Leonor Côrte-Real; Tânia S. Morais; Maria Helena Garcia; António Matos; Manuel Bicho. "Ruthenium based anticancer compounds: Insights into their uptake mechanisms and cellular targets". Paper presented in 4th World Congress on Cancer Science & Therapy, Chicago, USA, 2014.
  17. Tânia S. Morais; Fernanda Marques; M. Paula Robalo; Paulo J. A. Madeira; António Matos; M. Helena Garcia. "New water soluble ruthenium(II)cyclopentadienyl compound as potencial anticancer agent". Paper presented in EFMC International Symposium on Medicinal Chemistry, Lisbon, Portugal, 2014.
  18. Esteban Rodriguez Arce; Cynthia Sarniguet; Tânia S. Morais; Isabel Tomaz; Andrea Medeiros; Marcelo Comini; Javier Varela; et al. "Actividad en Líneas de Células Tumorales y Parásitos Trypanosomátidos de un Compuesto Organometálico Rutenio Clotrimazol". Paper presented in XV Jornadas de la Sociedad Uruguaya de Biociencias, Maldonado, Uruguai, 2014.
  19. Fernanda Marques; António P. Matos; Leonor Côrte-Real; Tânia S. Morais; M. Helena Garcia. "Novel Pathways for Anticancer Therapy:the Role of Golgi network in the mechanism of cell death of organometallic Ru complexes". Paper presented in Microscopy in Research, Almada, Portugal, 2013.
  20. M. Helena Garcia; Tânia S. Morais; Ana Isabel Tomaz; Andreia Valente; Fernanda Marques. "Cyclopentadienyl ruthenium(macro)metallodrugs: large spectrum antitumor agentes". Paper presented in Drug Discovery & Therapy World Congress, Boston, EUA, 2013.
  21. Cynthia Sarniguet; Tânia S. Morais; Ana Isabel Tomaz; Andrea Medeiros; Marcelo Comini; Lucía Otero; M. Helena Garcia; Dinorah Gambino. "New ruthenium(II) cyclopentadienyl thiosemicarbazone complexes with antitrypanosomal activity". Paper presented in 12th International Symposium on Metal Ions and Medicine, Punta del Este, Uruguay, 2013.
  22. Andreia Valente; M. Helena Garcia; Tânia S. Morais; Fernanda Marques; Yong Miao; Philippe Zinck. "New targeted bifunctional polymeric metal complexes for drug delivery in cancer therapy". Paper presented in 3rd National Meeting on Medicinal Chemistry, Aveiro, Portugal, 2012.
  23. Tânia S. Morais; M. Helena Garcia; Ana Isabel Tomaz; Fernanda Marques; Filipa Mendes. "New antitumor ruthenium(II) organometallic complexes: cytotoxicity and protein interaction". Paper presented in XXV International Conference on Organometallic Chemistry (ICOMC 2012), Lisbon, Portugal, 2012.
  24. Tânia S. Morais; M. Helena Garcia; Ana I. Tomaz; Fernanda Marques; Filipa Mendes. "New anti-tumour ruthenium(II) organometallic complexes: cytotoxicity and protein interaction". Paper presented in International Symposium on Metal Complexes, ISMEC 2012, Lisbon, Portugal, 2012.
  25. Tânia S. Morais; M. Helena Garcia; Ana Isabel Tomaz; Fernanda Marques; M. Paula Robalo; Paulo J. Amorim Madeira. "New ruthenium(II) cyclopentadienyl compounds: cytotoxicity and proteins binding". Paper presented in 11 International Symposium and Applied Bioinorganic Chemistry, Barcelona, Spain, 2011.
  26. M. Helena Garcia; Tânia S. Morais; M. Paula Robalo; M. José Villa de Brito. "New piano-stool ruthenium(II) complexes bearing 1-butylimidazole heteroaromatic ligand". Paper presented in XIX EuCheMS Conference on Organometallic Chemistry, Toulouse, France, 2011.
  27. Tânia S. Morais; M. Helena Garcia; Paulo J. Amorim Madeira; M. Helena Florêncio; Virtudes Moreno. "Interaction of new ruthenium(II) cyclopentadienyl compounds with proteins". Paper presented in XXII National Meeting SPQ, Braga, Portugal, 2011.
  28. Paulo J. Amorim Madeira; Tânia S. Morais; M. Helena Garcia; M. Helena Florêncio. "Gas-phase behaviour of ruthenium(II) cyclopentadienyl derivatives: an FT-ICR mass spectrometry study". Paper presented in XXII National Meeting SPQ, Braga, Portugal, 2011.
  29. Tânia S. Morais; M. Helena Garcia; Ana Isabel Tomaz; Paulo J.A. Madeira; M. Helena Florêncio; Fernanda Marujo Marques. "Novos compostos de “Ru(II)(eta5-C5H5)” como potenciais agentes anti-tumorais". Paper presented in Ciência QB-1º Encontro dos Alunos de Doutoramento do DQB – FCUL, Lisbon, Portugal, 2011.
  30. Tânia S. Morais; M. Helena Garcia; M. Paula Robalo; Andreia Valente; Virtudes Moreno; Mercè Font-Bardia; Teresa Calvet; Julia Lorenzo; Francesc X. Avilés. "Cytotoxicity studies and DNA interaction of new ruthenium(II) cyclopentadienyl complexes with nitrogen coordinated ligands". Paper presented in XII Iberic Meeting of electrochemistry & XVI Meetinf of the Portuguese Electrochemical Society (XII IME), Lisbon, Portugal, 2010.
  31. Susana Quintal; Tânia S. Morais; Paula Robalo; Fátima Piedade; Maria José Villa de Brito; Maria Helena Garcia; João Madureira; et al. "Design of Ferrocenyl Compounds with Leishmanicidal Activity". Paper presented in XV Brazilian Meeting on Inorganic Chemistry (XV BMIC), Angra dos Reis, Brasil, 2010.
  32. Ana Isabel Tomaz; Tamás Jakusch; Tânia S. Morais; Rodrigo F. M. de Almeida; Fernanda Marques; Éva A. Enyedy; João Costa Pessoa; Tamás Kiss; M. Helena Garcia. "Interaction of cytotoxic ruthenium(II) cyclopentadienyl complexes with serum albumin". Paper presented in 10th European Biological Inorganic Chemistry Conference (EUROBIC 2010), Thessalonica, Greece, 2010.
  33. Tânia S. Morais; M. Helena Garcia; Pedro Florindo; João Ribeiro; M. Paula Robalo; Virtudes Moreno; Julia Lorenzo; Francesc X. Avilés. "Studies of the antiproliferative activity of ruthenium(II) cyclopentadienyl derived complexes with nitrogen coordinated ligands". Paper presented in 8th Inorganic Chemistry Conference, Curia, Portugal, 2009.
  34. Maria J. Villa de Brito; Tânia S. Morais; João Madureira; Susana Quintal; M. Helena Garcia. "Synthesis and characterization of new ferrocenylamide compounds with appended N-heterocycles designed for Leishmanicidal activity". Paper presented in 8th Inorganic Chemistry Conference, Curia, Portugal, 2009.
  35. M. Fátima M. Piedade; M. Helena Garcia; Andreia Valente; Pedro Florindo; Tânia S. Morais; M. Teresa Duarte. "Molecular and crystal structures of new ruthenium(II) mixed metallocene derived complexes". Paper presented in 8th Inorganic Chemistry Conference, Curia, Portugal, 2009.
  36. Ana Isabel Tomaz; Tamás Jakusch; Tânia S. Morais; M. Helena Garcia; Éva A. Enyedy; João Costa Pessoa; Tamás Kiss. "Human Albumin Binding to Cytotoxic Ruthenium(II) Cyclopentadienyl-type Complexes". Paper presented in 10th International Symposium on Applied Bioinorganic Chemistry (ISABC 10), Debrecen, Hungry, 2009.
  37. M. Helena Garcia; Tânia S. Morais; Andreia Valente; M. Paula Robalo; Virtudes Moreno; Julia Lorenzo; Francesc X. Avilés. "DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands". Paper presented in XVIII EuCheMS International conference on Organometallic Chemistry, Goteborg, Sweden, 2009.
  38. M. Helena Garcia; Andreia Valente; Tânia S. Morais; Pedro Florindo; M. Fátima M. Piedade; Virtudes Moreno. "Studies on DNA interaction of new mixed metallocene ruthenium(II) derived complexes". Paper presented in International Conference on Organometallic Chemistry, Rennes, France, 2008.
Edited book
  1. Tânia S. Morais. 29th International Carbohydrate Symposium, Book of Abstracts. Lisbon, Portugal: on line. 2018.
    Published
Journal article
  1. Woods, Ben; Silva, Rúben D. M.; Schmidt, Claudia; Wragg, Darren; Cavaco, Marco; Neves, Vera; Ferreira, Vera F. C.; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): http://dx.doi.org/10.1021/acs.bioconjchem.0c00659.
    Published • 10.1021/acs.bioconjchem.0c00659
  2. Sequeira, Diogo; Baptista, Pedro V.; Valente, Ruben; Piedade, M. Fátima M.; Garcia, M. Helena; Morais, Tânia S.; Fernandes, Alexandra R.. "Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action". Dalton Transactions 50 5 (2021): 1845-1865. http://dx.doi.org/10.1039/d0dt03566a.
    Published • 10.1039/d0dt03566a
  3. João Franco Machado; Diogo Sequeira; Fernanda M. Marques; Maria Fátima Minas da Piedade; Maria José Villa de Brito; M. Helena Garcia; Alexandra R. Fernandes; Tânia S. Morais. "New copper(I) complexes selective for prostate cancer cells". Dalton Transactions (2020): https://pubs.rsc.org/en/content/articlelanding/2020/dt/d0dt02157a/unauth#!divAbstract.
    Published • 10.1039/D0DT02157A
  4. Franco Machado, João; Machuqueiro, Miguel; Marques, Fernanda M.; Robalo, Maria Paula Alves; Minas da Piedade, Maria Fátima; Garcia, Maria Helena; Correia, João D. G.; Morais, Tânia S.. "Novel "ruthenium cyclopentadienyl"-peptide conjugate complexes against human FGFR(+) breast cancer". Dalton Transactions 49 (2020): 5974-5987. http://dx.doi.org/10.1039/d0dt00955e.
    Published • 10.1039/d0dt00955e
  5. Diana Fontinha; Sílvia A. Sousa; Tânia S. Morais; Miguel Prudêncio; Jorge H. Leitão; Yann Le Gal; Dominique Lorcy; et al. "Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective antitumor, antimicrobial and antiplasmodial agentes". Metallomics 12 (2020): 974-987.
    Published • 10.1039/D0MT00064G
  6. Gano, Lurdes; Pinheiro, Teresa; Matos, António P.; Tortosa, Francisco; Jorge, Tiago F.; Gonçalves, Maria S.; Martins, Marta; et al. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry 19 10 (2019): 1262-1275. http://dx.doi.org/10.2174/1871520619666190318152726.
    Published • 10.2174/1871520619666190318152726
  7. Bravo, Catarina; Robalo, M. Paula; Marques, Fernanda; Fernandes, Alexandra R.; Sequeira, Diogo A.; M. Piedade, M. Fátima; Garcia, M. Helena; de Brito, Maria J. Villa; Morais, Tânia S.. "First heterobimetallic Cu(i)–dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity". New Journal of Chemistry 43 31 (2019): 12308-12317. http://dx.doi.org/10.1039/c9nj02068c.
    Published • 10.1039/c9nj02068c
  8. Tânia S. Morais; Yann Jousseaume; M. Fátima M. Piedade; Catarina Roma-Rodrigues; Alexandra R. Fernandes; Fernanda Marques; Maria J. Villa de Brito; M. Helena Garcia. "Important cytotoxic and cytostatic effects of new copper(i)–phosphane compounds with N,N, N,O and N,S bidentate ligands". Dalton Transactions 47 23 (2018): 7819-7829. https://doi.org/10.1039/C8DT01653D.
    Published • 10.1039/C8DT01653D
  9. Lopes, João; Alves, David; Morais, Tânia S.; Costa, Paulo J.; Piedade, M. Fátima M.; Marques, Fernanda; Villa de Brito, Maria J.; Helena Garcia, M.. "New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity". Journal of Inorganic Biochemistry 169 (2017): 68-78. http://dx.doi.org/10.1016/j.jinorgbio.2017.01.007.
    Published • 10.1016/j.jinorgbio.2017.01.007
  10. Mendes, Nuno; Tortosa, Francisco; Valente, Andreia; Marques, Fernanda; Matos, António; Morais, Tânia; Tomaz, Ana; Gärtner, Fátima; Garcia, Maria. "In vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model". Anti-Cancer Agents in Medicinal Chemistry 16 999 (2016): 1-1. http://dx.doi.org/10.2174/1871520616666160922165133.
    Published • 10.2174/1871520616666160922165133
  11. Morais, T.S.; Valente, A.; Tomaz, A.I.; Marques, F.; Garcia, M.H.. "Tracking antitumor metallodrugs: Promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds". Future Medicinal Chemistry 8 5 (2016): 527-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966471252&partnerID=MN8TOARS.
    Published • 10.4155/fmc.16.7
  12. Fernández, M.; Arce, E.R.; Sarniguet, C.; Morais, T.S.; Tomaz, A.I.; Azar, C.O.; Figueroa, R.; et al. "Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites". Journal of Inorganic Biochemistry 153 (2015): 306-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982686493&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2015.06.018
  13. Rodríguez Arce, E.; Sarniguet, C.; Moraes, T.S.; Vieites, M.; Tomaz, A.I.; Medeiros, A.; Comini, M.A.; et al. "A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites". Journal of Coordination Chemistry 68 16 (2015): 2923-2937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982070308&partnerID=MN8TOARS.
    Published • 10.1080/00958972.2015.1062480
  14. Côrte-Real, L.; Mendes, F.; Coimbra, J.; Morais, T.S.; Tomaz, A.I.; Valente, A.; Garcia, M.H.; et al. "Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes". Journal of Biological Inorganic Chemistry 19 6 (2014): 853-867. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905864221&partnerID=MN8TOARS.
    Published • 10.1007/s00775-014-1120-y
  15. Morais, T.S.; Santos, F.C.; Jorge, T.F.; Côrte-Real, L.; Madeira, P.J.A.; Marques, F.; Robalo, M.P.; et al. "New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution". Journal of Inorganic Biochemistry 130 1 (2014): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885498325&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.09.013
  16. Gonçalves, A.C.; Morais, T.S.; Robalo, M.P.; Marques, F.; Avecilla, F.; Matos, C.P.; Santos, I.; Tomaz, A.I.; Garcia, M.H.. "Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands". Journal of Inorganic Biochemistry 129 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882795489&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.07.033
  17. Quintal, S.; Morais, T.S.; Matos, C.P.; Paula Robalo, M.; Piedade, M.F.M.; Villa De Brito, M.J.; Helena Garcia, M.; et al. "Synthesis, structural characterization and leishmanicidal activity evaluation of ferrocenyl N-heterocyclic compounds". Journal of Organometallic Chemistry 745-746 (2013): 299-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883307751&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2013.07.044
  18. Côrte-Real, L.; Matos, A.P.; Alho, I.; Morais, T.S.; Tomaz, A.I.; Garcia, M.H.; Santos, I.; Bicho, M.P.; Marques, F.. "Cellular uptake mechanisms of an antitumor ruthenium compound: The endosomal/lysosomal system as a target for anticancer metal-based drugs". Microscopy and Microanalysis 19 5 (2013): 1122-1130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884579362&partnerID=MN8TOARS.
    Published • 10.1017/S143192761300175X
  19. Morais, T.S.; Santos, F.C.; Corte-Real, L.; Garcia, M.H.. "Exploring the effect of the ligand design on the interactions between [Ru(¿5-C5H5)(PPh3)(N,O)][CF 3SO3] complexes and human serum albumin". Journal of Inorganic Biochemistry 129 (2013): 94-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884952269&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.09.008
  20. Morais, T.S.; Santos, F.; Côrte-Real, L.; Marques, F.; Robalo, M.P.; Madeira, P.J.A.; Garcia, M.H.. "Biological activity and cellular uptake of [Ru(¿5-C 5H5)(PPh3)(Me2bpy)][CF 3SO3] complex". Journal of Inorganic Biochemistry 122 (2013): 8-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873704110&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2013.01.011
  21. Tomaz, A.I.; Jakusch, T.; Morais, T.S.; Marques, F.; De Almeida, R.F.M.; Mendes, F.; Enyedy, É.A.; et al. "[RuII(¿5-C5H5 (bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin". Journal of Inorganic Biochemistry 117 (2012): 261-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869080345&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2012.06.016
  22. Madeira, P.J.A.; Morais, T.S.; Silva, T.J.L.; Florindo, P.; Garcia, M.H.. "Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N-coordinated ligands by electrospray ionization mass spectrometry: Fragmentation pathways and energetics". Rapid Communications in Mass Spectrometry 26 15 (2012): 1675-1686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862733700&partnerID=MN8TOARS.
    Published • 10.1002/rcm.6276
  23. Morais, T.S.; Garcia, M.H.; Robalo, M.P.; Piedade, M.F.M.; Duarte, M.T.; Villa De Brito, M.J.; Amorim Madeira, P.J.. "Synthesis and structural characterization of new piano-stool ruthenium(II) complexes bearing 1-butylimidazole heteroaromatic ligand". Journal of Organometallic Chemistry 713 (2012): 112-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862600442&partnerID=MN8TOARS.
    Published • 10.1016/j.jorganchem.2012.04.024
  24. Morais, T.S.; Silva, T.J.L.; Marques, F.; Robalo, M.P.; Avecilla, F.; Madeira, P.J.A.; Mendes, P.J.G.; Santos, I.; Garcia, M.H.. "Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines". Journal of Inorganic Biochemistry 114 (2012): 65-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861986235&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2012.04.014
  25. Moreno, V.; Font-Bardia, M.; Calvet, T.; Lorenzo, J.; Avilés, F.X.; Garcia, M.H.; Morais, T.S.; Valente, A.; Robalo, M.P.. "DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands". Journal of Inorganic Biochemistry 105 2 (2011): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649615202&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2010.10.009
  26. Garcia, M.H.; Valente, A.; Florindo, P.; Morais, T.S.; Piedade, M.F.M.; Duarte, M.T.; Moreno, V.; Avilés, F.X.; Loreno, J.. "New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy". Inorganica Chimica Acta 363 14 (2010): 3765-3775. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957982339&partnerID=MN8TOARS.
    Published • 10.1016/j.ica.2010.05.034
  27. Moreno, V.; Lorenzo, J.; Aviles, F.X.; Garcia, M.H.; Ribeiro, J.P.; Morais, T.S.; Florindo, P.; Robalo, M.P.. "Studies of the antiproliferative activity of ruthenium (II) Cyclopentadienyl-derived complexes with nitrogen coordinated ligands". Bioinorganic Chemistry and Applications 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954567506&partnerID=MN8TOARS.
    Published • 10.1155/2010/936834
  28. Helena Garcia, M.; Morais, T.S.; Florindo, P.; Piedade, M.F.M.; Moreno, V.; Ciudad, C.; Noe, V.. "Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands". Journal of Inorganic Biochemistry 103 3 (2009): 354-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649090635&partnerID=MN8TOARS.
    Published • 10.1016/j.jinorgbio.2008.11.016
Newsletter article
  1. Tânia S. Morais. "Novos Compostos, Grandes Desafios", Química, Boletim da Sociedade Portuguesa de Química, 2014, https://www.spq.pt/magazines/BSPQuimica/665/article/30001893/pdf.
Online resource
  1. Tânia S. Morais. Paper selected by the Global Medical Discovery (online continuous dissemination): 2014 “Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes", Leonor Côrte-Real, Filipa Mendes, Joana Coimbra, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, M. Helena Garcia, Isabel Santos, Manuel Bicho, featured at Global Medical Discovery [ISSN 1929-8536]. 2014. https://globalmedicaldiscovery.com/?s=Anticancer+activity+of+structurally+related+ruthenium%28II%29+cyclopentadienyl+complexes.
  2. Tânia S. Morais. Paper selected by the Global Medical Discovery (online continuous dissemination): 2012 “[RuII( eta5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: cytotoxic activity and interaction with Human Serum Albumin”, Ana Isabel Tomaz, Tamás Jakusch, Tânia S. Morais, Rodrigo F. M. de Almeida, Fernanda Marques, Filipa Mendes, Eva A. Enyedy, João Costa Pessoa, Támas Kiss, M. Helena Garcia. 2012. http://globalmedicaldiscovery.com/key-scientific-articles/ruii%CE%B7%E2%81%B5-c%E2%82%85h%E2%82%85bipypph%E2%82%83%E2%81%BA-a-promising-large-spectrum-antitumor-agent-cytotoxic-activity-and-interaction-with-human-serum-albumin/.
Thesis / Dissertation
  1. Tânia S. Morais. "Síntese de novos complexos bioorganometálicos de ruténio e avaliação das suas propriedades anti-tumorais". PhD, Universidade de Lisboa Faculdade de Ciências, 2013. https://repositorio.ul.pt/handle/10451/9908.
  2. Tânia S. Morais. "Síntese e caracterização de complexos organometálicos citotóxicos derivados do fragmento “CpRu” e avaliação das suas potencialidades como agentes antitumorais". Master, Universidade de Lisboa Faculdade de Ciências, 2008. https://repositorio.ul.pt/handle/10451/1272.
  3. Tânia S. Morais. "Síntese e caracterização de complexos de Ru(II) e Fe(II) com ligandos azotados. Estudo preliminar sobre as suas potencialidades como agentes antitumorais". Degree, Universidade de Lisboa Faculdade de Ciências, 2007.

Intellectual property

Patent
  1. Maria Helena Garcia; Andreia Valente; Tânia S. Morais; Ana Isabel Tomaz. 2016. "Macromolecular transition metal complexes for treatment of cancer and process for their preparation".
    Granted/Issued
  2. Maria Helena Garcia; Andreia Valente; Tânia S. Morais; Ana Isabel Tomaz. 2014. "Novos complexos macromoleculares de metais de transição para tratamento do cancro". Portugal.
    Granted/Issued
  3. Maria Helena Garcia; Tânia S. Morais; Ana Isabel Tomaz; Fernanda Marques; Filipa Mendes. 2013. "Transition metal complexes for pharmaceutical applications". Portugal.
    Expired
  4. Maria Helena Garcia; Tânia S. Morais; Ana Isabel Tomaz; Fernanda Marques. 2013. "Water-soluble organometallic ruthenium and iron compounds presenting heteroaromatic ligands".
    Expired
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/04/21 |Invited| Ruthenium Chemistry for cancer therapy: ten years challenge _Tânia S. Morais Ciclo de Seminários da Universidade de Évora
(Évora, Portugal)
2020/02/06 Ruthenium-peptide conjugates for the selective treatment of triple-negative breast cancer_João D. G. Correia, João Franco Machado, Fernanda Marques, M. Helena Garcia, Tânia S. Morais 17th Iberian Peptide Meeting (EPI 2020)
(Madrid, Spain)
2019/11/22 Copper(I)-phosphane complexes as potencial anticancer agents_João Franco Machado, Fernanda Marques, M. Fátima M. Piedade, M. José Villa de Brito, Maria Helena Garcia, Tânia S. Morais XXIV Encontro Luso-Galego de Química
(Porto, Portugal)
2019/06/24 |Invited| Progress on the design of metal-based drugs for cancer therapy_M. Helena Garcia, Tânia S. Morais, Andreia Valente, Ana Isabel Tomaz 6th World Congress on Natural Product & Synthetic Chemistry (Synthetic Chemistry 2019)
(New York, United States)
2018/10/18 |Flash presentation| Synthesis and characterization of promising anticancer Cu(I) complexes_João Franco Machado, Fernanda Marques, M. Fátima M. Piedade, Maria Helena Garcia, Tânia S. Morais MMSE 2018 - Modern Methods of Structure Elucidation
(Lisbon, Portugal)
2017/05 |Invited| Ruthenium compounds as metallodrug candidates for cancer therapy_Ana Isabel Tomaz, Andreia Valente, Tânia S. Morais, Fernanda Marques, M. Helena Garcia BIT's 10th Annual World Cancer Congress 2017 (WCC2017)
(Barcelona, Spain)
2017 “Peptides as therapeutic agents”_Tânia S. Morais lecture on Biochemistry I from the 1st academic year of Sciences and Health Course, Faculdade de Ciências da Universidade de Lisboa, 2017
(Portugal)
2016/11 |Invited| Ruthenium new drugs: a promising future in cancer therapy? _M. Helena Garcia, Andreia Valente, Tânia S. Morais, Ana Isabel Tomaz World Congress on Cancer Research & Therapy
(Miami, United States)
2016/09/16 |Keynote| Ruthenium Drugs: a break in the wall_Tânia S. Morais Lilly CASE award day, Lilly UK pharmaceuticals
Lilly UK pharmaceuticals (WIndlesham, United Kingdom)
2016/06 |Invited| Ruthenium Organometallic compounds as promising antimetastatic drugs for breast cancer chemotherapy_M. Helena Garcia, Andreia Valente, Tânia S. Morais, Fernanda Marques European Chemistry Congress
(Rome, Italy)
2015/11 |Invited| Ruthenium drugs for cancer therapy: small structural changes, different in vivo performances M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Fernanda Marques, Andreia Valente 4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(Atlanta, United States)
2015/06 New ruthenium cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites_Esteban Rodríguez Arce, Mariana Fernández, Cynthia Sarniguet, Tânia S. Morais, Ana Isabel Tomaz, Claudio Olea Azar, Roberto Figueroa, J. Diego Maya, Andrea Medeiros, Marcelo Comini, M. Helena García, Lucía Otero and Dinorah Gambino 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13)
(Galway, Ireland)
2014/12/01 Targeting tumors with innovative ruthenium peptide complexes_Tânia S. Morais CQE Young Researchers Day
(Lisbon, Portugal)
2014/12 |Invited| Tracking antitumor drugs: ruthenium(II) cyclopentadienyl complexes as promising agents _M. Helena Garcia, Tânia S. Morais, Andreia Valente, Fernanda Marques 3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
(San Francisco, United States)
2014/11/27 Novos compostos organometálicos de ruténio na terapia do cancro_Tânia S. Morais, M. Helena Garcia XX Encontro Luso-Galego de Química
(Porto, Portugal)
2014/10 Ruthenium-based anticancer compounds: Insights into their uptake mechanisms and cellular targets_Fernanda Marques, Leonor Côrte-Real, Tânia S. Morais, Manuel Bicho, Maria Helena Garcia, António Matos 4th World Congress on Cancer Science & Therapy
(Chicago, United States)
2014/05/01 |Invited| New compounds, big challenges _Tânia S. Morais 4th Portuguese Young Chemist Meeting
(Coimbra, Portugal)
2014/03/26 Evaluation of the potential anti-tumoral properties of new ruthenium bioorganometallic compounds_Tânia S. Morais CCMM Seminars
(Lisbon, Portugal)
2013/09 Novel Pathways for Anticancer Therapy: the Role of Golgi network in the mechanism of cell death of organometallic complexes_Fernanda Marques, António P. Matos, Leonor Côrte-Real, Tânia S. Morais, Ana Isabel Tomaz, M. Helena Garcia, Manuel P. Bicho Microscopy at the Frontiers of Science, 2013: 3rd Joint Congress of the Portuguese and Spanish Microscopy Societies and Israel Society for Microscopy
(Tarragona, Spain)
2012/11 Promising organometallic ruthenium metallodrugs: RuII(¿5-C5H5)(bipy)(PPh3)]+ a promising large spectrum antitumor agent_Ana Isabel Tomaz, Tamás Jakusch, Tânia S. Morais, Rodrigo F. M. de Almeida, Fernanda Marques, Filipa Mendes, Éva A. Enyedy, M. Helena Garcia 3rd National Meeting on Medicinal Chemistry
(Aveiro, Portugal)
2012/09 Intracellular distribution of antitumor Ru(II) compounds: the lysossome and the lysosomal enzymes as targets for anticancer metal-based drugs_Fernanda Marques, Leonor Côrte-Real, António Matos, Irina Alho, Tânia S. Morais, Ana Isabel Tomaz, M. Helena Garcia, Manuel P. Bicho XLVI Congress of the Portuguese Society for Microscopy
(Lisbon, Portugal)
2011/09 A promising large spectrum new antitumor ruthenium agent: interaction with serum proteins ad mechanisms of cell death_Ana Isabel Tomaz, Tamás Jakusch, Tânia S. Morais, Rodrigo F. M. de Almeida, Fernanda Marques, Filipa Mendes, Éva A. Enyedy, João Costa Pessoa, Tamás Kiss, M. Helena Garcia 4th European Conference on Chemistry for Life Sciences
(Budapest, Hungary)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current New organometallic ruthenium complexes for breast cancer treatement
Supervisor of Marco Sá
 Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - Current Novos conjugados ruténio-péptido para a terapia seletiva do cancro a mama metastático
Supervisor of João Miguel Franco Machado
 Química (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/11 - 2020 Development of new inorganic Cu(I) complexes with potential application as anti-tumor agents
Supervisor of Maria Joana Lourenço
Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Synthesis of copper(I) complexes with potential anti-tumor application
Supervisor of Inês Dias Ribeiro
 Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019 Evaluation of Cu (I) compounds as novel chemotherapeutic agents
Co-supervisor of Diogo Sequeira
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Development of copper(I) complexes containing amino acids for cancer therapy
Supervisor of Vanessa Wilson
Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019 Development of copper(I) complexes for cancer therapy
Supervisor of Raquel Ferro
Química Aplicada (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 Synthesis of Cu (I) and Fe(II) complexes with potential anti-tumor application
Supervisor of Magdalena Sobieska
Erasmus + program (Portugal - Poland) - 2 month internship (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2018 Síntese de complexos de Cu(I) e Fe(II) com potencial aplicação anti-tumoral
Supervisor of Catarina Bravo
 Química (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2017 Desenvolvimento e produção de um medicamento: da abordagem da síntese laboratorial ao processo industrial
Supervisor of David Silva Rodrigues Alves
 Química Tecnológica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Synthesis of new ruthenium organometallic complexes functionalized with sugars for selective cancer therapy
Supervisor of Francisco Manuel Silvestre
Química + Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2015 Synthesis of copper(I) complexes with potential antitumor applications
Supervisor of Yann Jousseaume
Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Synthesis of copper and iron complexes with potential antitumor application
Co-supervisor of João Lopes
Química (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Synthesis of new ruthenium organometallic complexes with phosphates derived from sugars for potential application in selective therapy in cancer treatment
Supervisor of Rui Miguel Freitas
Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Synthesis of new organometallic complexes with potential application in the treatment of gliomas
Supervisor of David Alves
Química Tecnológica (Degree)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/02 - Current Member of the Organising and Scientific Committee of the 3rd edition of the CQE Days " Spring Meeting 2021" (2021/04/27 - 2021/04/28)
Conference (Member of the Scientific Committee)
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/01 - Current "Chem Forum@FCUL Centro de Química Estrutural" seminars: monthly scientific seminars of Centro de Química Estrutural, coveringseveral topics of Chemistry (since 2020) (2020/01)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/01 - 2020 Global Summit on Cancer Research and Therapy (https://www.thescientistt.com/cancer-research-therapy/) (2020/10/29 - 2020/10/30)
Conference (Member of the Organising Committee)
2019/01/01 - 2019/11/30 "International Year of Periodic Table 2019, celebrate 150 years _DQB-FCUL" Member of the Organising Committee for several events from January to November 2019 (2019/01/01 - 2019/11/30)
Other (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2019/02 - 2019/05 Member of the Organising and Scientific Committee of the 1st edition of the CQE Days " Spring Meeting 2019 "(https://cqe.tecnico.ulisboa.pt/cqedays) (2019/05/30 - 2019/05/31)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2017/10/01 - 2018/07/19 Member of the Organising Committee of the 29th International Carbohydrate Symposium (http://www.ics2018.eventos.chemistry.pt/) (2018/07/15 - 2018/07/19)
Congress (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/11/27 - Current | Outreach Activity | Participation in the European Researchers' Night with the video "Podem os metalofármacos ser uma boa aposta para a terapia do cancro?" - Festival de Curtas - Química para Todos@ULisboa; Vídeo disponível em: https://www.youtube.com/watch?v=Dea38ODk6T4&feature=emb_logo
Exhibition
 European Researchers' Night 2020
European Commission, Belgium
2011 - Current | Outreach Activities | Participation in several activities that promote interaction between the community and FCUL: Verão ULisboa (years 2018, 2019); Dia Aberto DQB, FCUL (years 2018, 2019); Ser Cientista, FCUL (year 2016); Open Lab Days to secondary school students (since 2011 to 2019); Dia Aberto, FCUL (since 2009 to 2019); Scientist Speed Dating @ DQB (2019); SPEED DATING com os cientistas at FCUL (2019)
Other
 Several activities that promote interaction between the community and FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/01/29 - 2019/01/29 | Outreach Activity | IYPT -International Year of the PeriodicTable | Flashmob Flash mob involving both students andprofessors/researchers, each identified as an Element of thePeriodic Table and performed on the Periodic Table paint located on the entrance of C8 building -FCUL. The event was filmed by air and on the ground.https://photos.app.goo.gl/t9o8aTYdreixDTjh7;http://iypt2019.campus.ciencias.ulisboa.pt/index.html ;https://youtu.be/bmVMJoynb1Q
Exhibition
 FlashMob | Cerimónia de abertura do Ano Internacional da Tabela Periódica 2019
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/05/12 - 2014/05/12 Complementary Training - "Egas Moniz Symposium on Electron Microscopy, An Overview of Scientific Applications"
Symposium
Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2011/10/10 - 2011/10/15 1st International Summer School on Modern Chemistry
Workshop
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/12/13 - 2010/12/17 Complementary Training - Modern Methods of Structure and Elucidation 2010 (theoretical and practical components)
Workshop
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/12/03 - 2009/12/03 Complementary Training - Brucker NMR users meeting-Portugal 2009
Meeting
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/12/02 - 2009/12/02 Complementary Training -Biomolecular NMR from liquids to solids
Meeting
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/09 Synthesis and characterization of Molybdenum complexes as CO release systems for the treatment of cancer
President of the jury
 Marcelo Nunes (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07 Study of the antimicrobial activity of compounds derived from sugars
President of the jury
 Mónica Miranda (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07 Luminescent iron (III) compounds for spin transition
President of the jury
 Ana Rita Reis (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07 New ruthenium complexes containing derivatized benzonitriles as potential anti-cancer agents
(Thesis) Arguer
 Jorge Valentim (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/07 Study of the degradation and detection of pollutants
(Thesis) Main arguer
 Duarte Antunes (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/07 Synthesis of new complexes of endogenous metals with anticancer potential
(Thesis) Main arguer
 Beatriz Filipa Afonso Moreno (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/06 Synthesis and biological evaluation of a peptide containing a TRAF6-binding sequence
(Thesis) Main arguer
 Susana Catapirra Magessi Ferreira (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/07 New Fe (III) and Co (II) Complexes with Ligands Derived from Hydrazides
(Thesis) Main arguer
 Rafaela Farelo Silva Tenera Marques (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2020/05 - Current Royal Society of Chemistry Member
2016 - Current The American Association for Advance of Science Member
2016 - Current Marie Curie Alumni Association Member
2015 - Current College of Chemistry of ULisboa Member
2001 - Current Sociedade Portuguesa de Química Member

Committee member

Activity description
Role 		Institution / Organization
2020/02/01 - Current Member of the comission responsible for the mensal CQE Newsletter (since 2020)
Member
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/01 - Current Member of communication and image committee of CQE
Member
 Universidade de Lisboa Centro de Química Estrutural, Portugal
2017/09 - Current Member of editorial board of Journal of Pharmacology and Pharmaceutical Research http://www.thebiomedica.org/pharmacology-pharmaceutical-research-editorial-board.php
Member

Conference scientific committee

Conference name Conference host
2021/02 - Current Member of scientific committee of 3rd edition of the CQE Days "Spring Meeting 2021" Centro de Química Estrutural
2019/02/01 - 2019/05/31 Member of scientific committee of 1st edition of the CQE Days "Spring Meeting 2019" Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/02 - Current Bioquímica Inorgânica/Inorganic Biochemistry Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09 - Current Química Inorgânica Complementar/Complementary Inorganic Chemistry Química (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/02 - 2018/07 Química Inorgânica/Inorganic Chemistry Química (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/02 - 2018/07 Laboratório de Sínteses e Desenvolvimento de Productos/Laboratory of Synthesis and Development of Products Química Tecnológica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/02 - 2017/07 Bioquímica/Biochemistry Ciências da Saúde (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2014/02 - 2015/07 Bioquímica/Biochemistry Biologia (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Interview (tv / radio show)

Program Topic
2020/12/11 - Current 90s de Ciência Tânia Morais – Investigação Desenvolve Composto Para Tratar O Cancro Da Mama Triplo Negativo - EPS 980

Journal scientific committee

Journal title (ISSN) Publisher
2021/01 - Current Polyhedron Elseviers
2021/01 - Current Acta Chimica Slovenica Slovenian Chemical Society
2021/01 - Current Chemical Papers Springer
2020/12 - Current Molecules MDPI
2020/11 - Current Pharmaceuticals MDPI
2020/09 - Current Frontiers in Chemistry
2020/01 - Current Dalton Transactions Royal societry of Chemistry
2019/08 - Current Inorganica Chimica Acta (0020-1693) Elsevier
2019/03 - Current Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Elsevier
2018/11 - Current Current Medicinal Chemistry (0929-8673) Bentham Science
2018/11 - Current Medicinal Chemistry Bentham Science Publishers
2018/10 - Current Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publishers
2018 - Current Journal of Chemistry Hindawi
2015 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2014/11 - Current Advances in Chemistry (2314-7571) Hindawi Limited
Distinctions

Award

2016 Granted with an honorarium by Lilly UK pharmaceuticals
Lilly UK pharmaceuticals , United Kingdom
2015 First prize in ScienceIN2Business Initiative, TecLabs for Translational Research, 2015 (M. Helena Garcia, Andreia Valente, Tânia S. Morais, A. Isabel Tomaz, "Rupharma")
TecLabs , Portugal
2014 Portuguese Young Chemist Award 2014 (PYC-Gradiva 2014)
Sociedade Portuguesa de Química, Portugal
2013 Best poster prize - Drug Discovery & Therapy World Congress, 2013, M. Helena Garcia, Tânia S. Morais, Ana Isabel Tomaz, Andreia Valente, Fernanda Marques, "Cyclopentadienyl ruthenium (macro)metallodrugs: large spectrum antitumor agents"
Drug Discovery & Therapy World Congress, United States

Title

2021 Lead Guest Editor of the special issue "Rational Drug Design of Metal Complexes for Cancer Therapy" from Frontiers in chemistry since 2021 to present
2021 Acting as guest editor for Chemistry, MDPI (2021)
2020 Lead Guest Editor of the special issue "Target-Specific Delivery of Gold and Ruthenium Complexes to Cancer Cells: Where Are We?" from Molecules, MDPI since 2020 to present
2020 Topic Editor of Molecules MDPI (https://www.mdpi.com/journal/molecules/topic_editors)_since 2020
2020 Topic Editor of Pharmaceutics MDPI (https://www.mdpi.com/journal/pharmaceutics/topic_editors)_since 2020
2019 Guest Editor of the special issue "1st CQE Days Meeting: 44 Years Connecting People and Chemistry" from Molecules, MDPI since May 2009 to April 2020 (https://www.mdpi.com/journal/molecules/special_issues/CQE_days_meeting)
2019 Acting as guest editor for Anti-Cancer Agents in Medicinal Chemistry, Bentham Science (2019)
2018 Acting as guest editor for Journal of Chemistry, Hindawi (2018)
2016 Selected for participation in the AAAS/science program for Excellence in Science (The American Association for Advance of Science)
The American Association for Advance of Science, United States

Other distinction

2020 Paper Dalton Trans., 2020, 49, 12273-12286. Selected as HOT TOPIC (October2020)
2017 |Media Citation| "Novo complexo de Ruténio inibe o desenvolvimento de metástases in vivo", Website ASPIC
2017 |Media Citation| "In vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model", Website ASPIC
2017 |Media Citation| "Novos complexos de cobre(I) e cobre(I)-ruténio(II) promissores para a terapia do cancro", Website ASPIC
2017 9th place (in 25) on the “most downloaded papers in last 90 days” from J. Inorg. Biochem., with the paper Journal of Inorganic Biochemistry, 169, 2017, 68-78, June 2017.
2014 |Media Citation| "Tânia Morais galardoada com o Portuguese Young Chemists Award", Website Diário Digital
2014 |Media Citation| "Pós-doutorada da ULisboa distinguida com Portuguese Young Chemists Award 2014", Website ULisboa
2014 |Media Citation| "Tânia Morais identificou compostos eficientes contra várias linhas celulares cancerígenas", Website TVciência
2014 |Media Citation| "Tânia Morais identificou compostos eficientes contra várias linhas celulares cancerígenas", Website PortugalNews
2014 |Media Citation| "Investigadora recebe «Portuguese Young Chemists Award» pelo trabalho «Novos compostos, grandes desafios»", Website Diário Digital
2014 |Media Citation| "Jovens cientistas: Tânia S. Morais" Website FCUL
2014 1st place (in 25) on the “most downloaded papers in last 90 days” from J. Inorg. Biochem., with the paper Journal of Inorganic Biochemistry, 130, 2014, 1-14, February 2014.
2014 6th place (in 25) on the “most downloaded papers in last 90 days” from J. Inorg. Biochem., with the paper Journal of Inorganic Biochemistry, 129, 2013, 1 - 8, January 2014.
2013 |Media Citation| "1º Prémio no "Drug Discovery & Therapy World Congress 2013"
2013 |Media Citation| "Cancro: Portuguesas vencem prémio mundial nos EUA"
2013 |Media Citation| In the Portuguese News/TVI television channel "Jornal da 8(TVI): Os comentários do Prof. Marcelo Rebelo de Sousa"
2013 11th place (in 25) on the “most downloaded papers in last 90 days” from J. Inorg. Biochem., with the paper Journal of Inorganic Biochemistry, 122, 2013, 8 – 17, March 2013.