M. Carmo-Fonseca has authored more than 150 original research articles, review articles and book chapters with a total of approximately 10 thousand citations (h index 54). Her lab is known for studies on RNA splicing using a combination of cutting-edge cell imaging and genome-wide approaches. The vision of her research group is to understand how RNA molecules, with their ability to both encode information and exert catalytic activities, contribute to the regulation of gene expression and how this knowledge can be translated into novel disease biomarkers and therapies. For the past 10 years, Carmo-Fonseca has implemented methodologies that allow tracking single RNA molecules in time and space inside the nucleus of living cells. She did a sabbatical hands-on training at Harvard Medical School, in Tom Kirchhausen's lab, where she developed a strategy that permits direct measurements of intron dynamics in single pre-mRNA molecules in live cells. This approach revealed that splicing can occur within a few seconds after transcription. To further investigate the timing of premRNA splicing relative to the position of RNA polymerase II (Pol II), Carmo-Fonseca started a collaboration with Nick Proudfoot at the University of Oxford, who had developed a novel strategy for Native Elongation Transcript sequencing (NET-seq). Together they unraveled unanticipated dynamic links between Pol II and the spliceosome. Drawing on her previous work indicating that reciprocal interconnectivity between the different steps required for gene activation plays a critical role ensuring efficiency and fidelity of gene expression, Carmo-Fonseca became interested in understanding how defects in gene expression regulation contribute to disease phenotypes and could be targeted for treatment.

Identificação pessoal

Nome completo
Maria Carmo-Fonseca

Nomes de citação

  • Carmo-Fonseca, Maria

Identificadores de autor

Ciência ID

Endereços de correio eletrónico

  • carmo.fonseca@medicina.ulisboa.pt (Profissional)


  • Avenida Professor Egas Moniz, Edificio Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)


Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética


Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Grau Classificação
Medicina (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
Percurso profissional


Categoria Profissional
Instituição de acolhimento
1993 - Atual Investigador Coordenador (carreira) (Investigação) Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular, Portugal


Designação Financiadores
2020/11/01 - 2023/10/30 RNA mis-splicing in hypertrophic cardiomyopathy: opportunities for diagnosis and therapy
Investigador responsável
Em curso
2019/09/01 - 2022/08/31 RNA in disease (RiboMed)
Investigador responsável
Em curso
2018/07/01 - 2021/06/30 Gene-edited organoids to study the functional impact of BRCA1 and BRCA2 mutations
Investigador responsável
Em curso
2016/12/01 - 2020/11/30 PRECISE: Accelerating progress toward the new era of precision medicine.
Investigador responsável
Em curso
2016/05/01 - 2019/10/31 Making sense of antisense transcription
Investigador responsável


Artigo em revista
  1. Tammer, Luna; Hameiri, Ofir; Keydar, Ifat; Roy, Vanessa Rachel; Ashkenazy-Titelman, Asaf; Custódio, Noélia; Sason, Itay; et al. "Gene architecture directs splicing outcome in separate nuclear spatial regions". Molecular Cell 82 5 (2022): 1021-1034.e8. http://dx.doi.org/10.1016/j.molcel.2022.02.001.
    Publicado • 10.1016/j.molcel.2022.02.001
  2. Sousa-Luís, Rui; Carmo-Fonseca, Maria. "Pseudouridylation: A new player in co-transcriptional splicing regulation". Molecular Cell 82 3 (2022): 495-496. http://dx.doi.org/10.1016/j.molcel.2022.01.010.
    Publicado • 10.1016/j.molcel.2022.01.010
  3. Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364.
    Acesso aberto • Publicado • 10.1016/j.scr.2021.102364
  4. Sousa-Luís, Rui; Dujardin, Gwendal; Zukher, Inna; Kimura, Hiroshi; Weldon, Carika; Carmo-Fonseca, Maria; Proudfoot, Nick J.; Nojima, Takayuki. "POINT technology illuminates the processing of polymerase-associated intact nascent transcripts". Molecular Cell 81 9 (2021): 1935-1950.e6. http://dx.doi.org/10.1016/j.molcel.2021.02.034.
    Acesso aberto • Publicado • 10.1016/j.molcel.2021.02.034
  5. Silva, Teresa P.; Pereira, Carolina A.; Oliveira, Ana Rita; Raposo, Ana Cláudia; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; da Rocha, Simão T.. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research 52 (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242.
    Acesso aberto • Publicado • 10.1016/j.scr.2021.102242
  6. Silveira, Catarina; Sousa, Ana Carla; Janeiro, André; Malveiro, Sara; Teixeira, Encarnação; Brysch, Eva; Pantarotto, Marcos; et al. "Detection and quantification of EGFR T790M mutation in liquid biopsies by droplet digital PCR". Translational Lung Cancer Research 10 3 (2021): 1200-1208. http://dx.doi.org/10.21037/tlcr-20-1010.
    Acesso aberto • Publicado • 10.21037/tlcr-20-1010
  7. Luis R. Lopes; Pedro Barbosa; Mario Torrado; Ellie Quinn; Ana Merino; Juan Pablo Ochoa; Joanna Jager; et al. "Cryptic Splice-Altering Variants in MYBPC3 Are a Prevalent Cause of Hypertrophic Cardiomyopathy". Circulation: Genomic and Precision Medicine 13 3 (2020): https://doi.org/10.1161/CIRCGEN.120.002905.
  8. Ribeiro, Marta; Furtado, Marta; Martins, Sandra; Carvalho, Teresa; Carmo-Fonseca, Maria. "RNA Splicing Defects in Hypertrophic Cardiomyopathy: Implications for Diagnosis and Therapy". International Journal of Molecular Sciences 21 4 (2020): 1329. http://dx.doi.org/10.3390/ijms21041329.
    Acesso aberto • Publicado • 10.3390/ijms21041329
  9. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Vaz, Sandra H.; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00070.
    Acesso aberto • Publicado • 10.3389/fbioe.2020.00070
  10. Carmo-Fonseca, Maria. "Detection of rare and novel EGFR mutations in NSCLC patients: implications for treatment-decision". Lung Cancer 139 (2020): 35-40.
    Acesso aberto • Publicado
  11. Joana Desterro; Pedro Bak-Gordon; Maria Carmo-Fonseca. "Targeting mRNA processing as an anticancer strategy". Nature Reviews Drug Discovery (2019): https://doi.org/10.1038/s41573-019-0042-3.
  12. Prudêncio, Pedro; Rebelo, Kenny; Grosso, Ana Rita; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. "Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data". Methods (2019): http://dx.doi.org/10.1016/j.ymeth.2019.09.003.
    Acesso aberto • Publicado • 10.1016/j.ymeth.2019.09.003
  13. Carmo-Fonseca, Maria. "Design principles for pluripotent stem cell-derived organoid engineering". Stem Cells International (2019):
  14. Carmo-Fonseca, Maria. "RNA Polymerase II phosphorylated on CTD Serine 5 interacts with the spliceosome during co-transcriptional splicing". Molecular Cell 72 2 (2018): 369-379.
    Acesso aberto • Publicado
  15. Carmo-Fonseca, Maria. "Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safegards stem cell pluripotency". Nature Communications 9 1 (2018): 94.
    Acesso aberto • Publicado
  16. Teresa Carvalho; Sandra Martins; José Rino; Sérgio Marinho; Maria Carmo-Fonseca. "Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay". Journal of Cell Science 130 9 (2017): 1519-1531. https://doi.org/10.1242/jcs.202200.
  17. Almeida, Rita Mendes de; Tavares, Joana; Martins, Sandra; Carvalho, Teresa; Enguita, Francisco J.; Brito, Dulce; Fonseca, Maria Carmo; Lopes, Luís Rocha. "Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy". (2017): http://hdl.handle.net/10451/34199.
  18. Carmo-Fonseca, Maria. "Distinctive patterns of transcription and RNA processing for human lincRNAs". Molecular Cell 65 1 (2017): 25-38.
    Acesso aberto • Publicado
  19. Carmo-Fonseca, Maria. "Deep intronic mutations and human disease". Human Genetics 136 9 (2017): 1093-1111.
    Acesso aberto • Publicado
  20. Carmo-Fonseca, Maria. "Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing". Cell 161 3 (2015): 526-540.
    Acesso aberto • Publicado
  21. Carmo-Fonseca, Maria. "Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity". Cell Reports (2013):
    doi: 10.1016/j.celrep.2013.08.013
  22. Kumar, R.; Horvath, A.; Mazumder, R.; Toi, M.; Sato, F.; Pillai, M.R.; Costa, L.; et al. "The Global Cancer Genomics Consortium's Second Annual Symposium: Genomics Medicine in Cancer Research". Genes and Cancer 4 5-6 (2013): 196-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887424286&partnerID=MN8TOARS.
  23. Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; De Almeida, S.F.. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription". Nucleic Acids Research 41 5 (2013): 2881-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876365300&partnerID=MN8TOARS.
  24. Rino, J.; Martin, R.M.; Carvalho, T.; Carmo-Fonseca, M.. "Imaging dynamic interactions between spliceosomal proteins and pre-mRNA in living cells". Methods (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84882781970&partnerID=MN8TOARS.
  25. Martin, R.M.; Rino, J.; Carvalho, C.; Kirchhausen, T.; Carmo-Fonseca, M.. "Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity". Cell Reports 4 6 (2013): 1144-1155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884595844&partnerID=MN8TOARS.
  26. Carmo-Fonseca, Maria. "Dynamic transitions in RNA polymerase II density profiles during transcription termination". Genome Research (2012):
    doi: 10.1101/gr.138057.112
  27. Auboeuf, D.; Carmo-Fonseca, M.; Valcarcel, J.; Biamonti, G.. "Alternative splicing and cancer". Journal of Nucleic Acids 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868218983&partnerID=MN8TOARS.
  28. de Almeida, S.F.; Carmo-Fonseca, M.. "Design principles of interconnections between chromatin and pre-mRNA splicing". Trends in Biochemical Sciences 37 6 (2012): 248-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861925259&partnerID=MN8TOARS.
  29. Grosso, A.R.; De Almeida, S.F.; Braga, J.; Carmo-Fonseca, M.. "Dynamic transitions in RNA polymerase II density profiles during transcription termination". Genome Research 22 8 (2012): 1447-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864577725&partnerID=MN8TOARS.
  30. Carmo-Fonseca, M.; Rino, J.. "RNA seeds nuclear bodies". Nature Cell Biology 13 2 (2011): 110-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551614017&partnerID=MN8TOARS.
  31. De Almeida, S.F.; Grosso, A.R.; Koch, F.; Fenouil, R.; Carvalho, S.; Andrade, J.; Levezinho, H.; et al. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36". Nature Structural and Molecular Biology 18 9 (2011): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052445151&partnerID=MN8TOARS.
  32. Cardoso, B.A.; De Almeida, S.F.; Laranjeira, A.B.A.; Carmo-Fonseca, M.; Yunes, J.A.; Coffer, P.J.; Barata, J.T.. "TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells". Leukemia 25 10 (2011): 1578-1586. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054032532&partnerID=MN8TOARS.
  33. Carmo-Fonseca, M.; Berciano, M.T.; Lafarga, M.. "Orphan nuclear bodies.". Cold Spring Harbor perspectives in biology 2 9 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952111765&partnerID=MN8TOARS.
  34. Martins, S.B.; Rino, J.; Carvalho, T.; Carvalho, C.; Yoshida, M.; Klose, J.M.; De Almeida, S.F.; Carmo-Fonseca, M.. "Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genes". Nature Structural and Molecular Biology 18 10 (2010): 1115-1123. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455164573&partnerID=MN8TOARS.
  35. De Almeida, S.F.; García-Sacristán, A.; Custódio, N.; Carmo-Fonseca, M.. "A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination". Nucleic Acids Research 38 22 (2010): 8015-8026. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650445002&partnerID=MN8TOARS.
  36. Mollet, I.G.; Ben-Dov, C.; Felício-Silva, D.; Grosso, A.R.; Eleutério, P.; Alves, R.; Staller, R.; Silva, T.S.; Carmo-Fonseca, M.. "Unconstrained mining of transcript data reveals increased alternative splicing complexity in the human transcriptome". Nucleic Acids Research 38 14 (2010): 4740-4754. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955793696&partnerID=MN8TOARS.
  37. De Almeida, S.F.; Carmo-Fonseca, M.. "Cotranscriptional RNA checkpoints". Epigenomics 2 3 (2010): 449-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954093775&partnerID=MN8TOARS.
  38. Bhatt, L.; Murphy, C.; O'Driscoll, L.S.; Carmo-Fonseca, M.; McCaffrey, M.W.; Fleming, J.V.. "N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding". FEBS Journal 277 15 (2010): 3219-3234. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954746560&partnerID=MN8TOARS.
  39. Carmo-Fonseca, Maria. "Follow that messenger : live-imaging a journey out of the nucleus". (2010): http://hdl.handle.net/10451/5892.
    doi: 10.1016/j.devcel.2010.05.021
  40. Almeida, Sérgio F. de; García-Sacristán, Ana; Custódio, Noélia; Carmo-Fonseca, Maria. "A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination". (2010): http://hdl.handle.net/10451/6360.
  41. Tavanez, J.P.; Bengoechea, R.; Berciano, M.T.; Lafarga, M.; Carmo-Fonseca, M.; Enguita, F.J.. "Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1". PLoS ONE 4 7 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68149091769&partnerID=MN8TOARS.
  42. Rino, J.; Carmo-Fonseca, M.. "The spliceosome: a self-organized macromolecular machine in the nucleus?". Trends in Cell Biology 19 8 (2009): 375-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-68549111145&partnerID=MN8TOARS.
  43. David-Ferreira, J.-F.; Carmo-Fonseca, M.. "Augusto Celestino da Costa (1884-1956) - Professor, scientist and science promoter". International Journal of Developmental Biology 53 8-10 (2009): 1161-1164. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949090466&partnerID=MN8TOARS.
  44. Rino, J.; Braga, J.; Henriques, R.; Carmo-Fonseca, M.. "Frontiers in fluorescence microscopy". International Journal of Developmental Biology 53 8-10 (2009): 1569-1579. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949155180&partnerID=MN8TOARS.
  45. Carmo-Fonseca, M.. "Idealism and romantic patriotism for science: An interview with José Francisco David-Ferreira". International Journal of Developmental Biology 53 8-10 (2009): 1273-1275. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449198694&partnerID=MN8TOARS.
  46. Heyd, F.; Carmo-Fonseca, M.; Möröy, T.. "Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26". Journal of Biological Chemistry 283 28 (2008): 19636-19645. http://www.scopus.com/inward/record.url?eid=2-s2.0-50349095324&partnerID=MN8TOARS.
  47. Grosso, A.R.; Gomes, A.Q.; Barbosa-Morais, N.L.; Caldeira, S.; Thorne, N.P.; Grech, G.; von Lindern, M.; Carmo-Fonseca, M.. "Tissue-specific splicing factor gene expression signatures". Nucleic Acids Research 36 15 (2008): 4823-4832. http://www.scopus.com/inward/record.url?eid=2-s2.0-50849145126&partnerID=MN8TOARS.
  48. Grosso, A.R.; Martins, S.; Carmo-Fonseca, M.. "The emerging role of splicing factors in cancer". EMBO Reports 9 11 (2008): 1087-1093. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549143293&partnerID=MN8TOARS.
  49. Carneiro, T.; Carvalho, C.; Braga, J.; Rino, J.; Milligan, L.; Tollervey, D.; Carmo-Fonseca, M.. "Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus". Molecular Biology of the Cell 19 4 (2008): 1499-1508. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949195905&partnerID=MN8TOARS.
  50. Rino, J.; Desterro, J.M.P.; Pacheco, T.R.; Gadella Jr., T.W.J.; Carmo-Fonseca, M.. "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Molecular and Cellular Biology 28 9 (2008): 3045-3057. http://www.scopus.com/inward/record.url?eid=2-s2.0-42349112032&partnerID=MN8TOARS.
  51. de Almeida, S.F.; Carmo-Fonseca, M.. "The CTD role in cotranscriptional RNA processing and surveillance". FEBS Letters 582 14 (2008): 1971-1976. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449142796&partnerID=MN8TOARS.
  52. Carmo-Fonseca, M.; Carvalho, C.. "Nuclear organization and splicing control.". Advances in experimental medicine and biology 623 (2007): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-42449105386&partnerID=MN8TOARS.
  53. Carmo-Fonseca, M.. "How genes find their way inside the cell nucleus". Journal of Cell Biology 179 6 (2007): 1093-1094. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249055144&partnerID=MN8TOARS.
  54. De Almeida, S.F.; Fleming, J.V.; Azevedo, J.E.; Carmo-Fonseca, M.; De Sousa, M.. "Stimulation of an unfolded protein response impairs MHC class I expression". Journal of Immunology 178 6 (2007): 3612-3619. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947220268&partnerID=MN8TOARS.
  55. Braga, J.; McNally, J.G.; Carmo-Fonseca, M.. "A reaction-diffusion model to study RNA motion by quantitative fluorescence recovery after photobleaching". Biophysical Journal 92 8 (2007): 2694-2703. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147151617&partnerID=MN8TOARS.
  56. Carneiro, T.; Carvalho, C.; Braga, J.; Rino, J.; Milligan, L.; Tollervey, D.; Carmo-Fonseca, M.. "Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus". Molecular and Cellular Biology 27 11 (2007): 4157-4165. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347332400&partnerID=MN8TOARS.
  57. De Almeida, S.F.; Picarote, G.; Fleming, J.V.; Carmo-Fonseca, M.; Azevedo, J.E.; De Sousa, M.. "Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation". Journal of Biological Chemistry 282 38 (2007): 27905-27912. http://www.scopus.com/inward/record.url?eid=2-s2.0-34948859111&partnerID=MN8TOARS.
  58. Rino, J.; Carvalho, T.; Braga, J.; Desterro, J.M.P.; Lührmann, R.; Carmo-Fonseca, M.. "A stochastic view of spliceosome assembly and recycling in the nucleus". PLoS Computational Biology 3 10 (2007): 2019-2031. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748935227&partnerID=MN8TOARS.
  59. Custódio, N.; Vivo, M.; Antoniou, M.; Carmo-Fonseca, M.. "Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription site". Journal of Cell Biology 179 2 (2007): 199-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548953842&partnerID=MN8TOARS.
  60. Barbosa-Morais, N.L.; Carmo-Fonseca, M.; Aparício, S.. "Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion". Genome Research 16 1 (2006): 66-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-30044435456&partnerID=MN8TOARS.
  61. Custódio, N.; Antoniou, M.; Carmo-Fonseca, M.. "Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling". Experimental Cell Research 312 13 (2006): 2557-2567. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745835437&partnerID=MN8TOARS.
  62. Kozlova, N.; Braga, J.; Lundgren, J.; Rino, J.; Young, P.; Carmo-Fonseca, M.; Visa, N.. "Studies on the role of NonA in mRNA biogenesis". Experimental Cell Research 312 13 (2006): 2619-2630. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840844&partnerID=MN8TOARS.
  63. Pacheco, T.R.; Ferreira Moita, L.; Quintal Gomes, A.; Hacohen, N.; Carmo-Fonseca, M.. "RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts". Molecular Biology of the Cell 17 10 (2006): 4187-4199. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749471110&partnerID=MN8TOARS.
  64. Pacheco, T.R.; Coelho, M.B.; Desterro, J.M.P.; Mollet, I.; Carmo-Fonseca, M.. "In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site". Molecular and Cellular Biology 26 21 (2006): 8183-8190. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750053338&partnerID=MN8TOARS.
  65. Mollet, I.; Barbosa-Morais, N.L.; Andrade, J.; Carmo-Fonseca, M.. "Diversity of human U2AF splicing factors: Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest". FEBS Journal 273 21 (2006): 4807-4816. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750062258&partnerID=MN8TOARS.
  66. Gama-Carvalho, M.; Barbosa-Morais, N.L.; Brodsky, A.S.; Silver, P.A.; Carmo-Fonseca, M.. "Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors". Genome Biology 7 11 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33847693938&partnerID=MN8TOARS.
  67. Custódio, N.; Carvalho, C.; Carneiro, T.; Carmo-Fonseca, M.. "In Situ Hybridization for Simultaneous Detection of DNA, RNA, and Protein". Cell Biology, Four-Volume Set 3 (2006): 419-427. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884892207&partnerID=MN8TOARS.
  68. Gama-Carvalho, M.; Carmo-Fonseca, M.. "Heterokaryons: An assay for nucleocytoplasmic shuttling". Cell Biology, Four-Volume Set 2 (2006): 277-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884892292&partnerID=MN8TOARS.
  69. Desterro, J.M.P.; Keegan, L.P.; Jaffray, E.; Hay, R.T.; O'Connell, M.A.; Carmo-Fonseca, M.. "SUMO-1 modification alters ADAR1 editing activity". Molecular Biology of the Cell 16 11 (2005): 5115-5126. http://www.scopus.com/inward/record.url?eid=2-s2.0-27644479211&partnerID=MN8TOARS.
  70. Tavanez, J.P.; Calado, P.; Braga, J.; Lafarga, M.; Carmo-Fonseca, M.. "In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1". RNA 11 5 (2005): 752-762. http://www.scopus.com/inward/record.url?eid=2-s2.0-17844369724&partnerID=MN8TOARS.
  71. Fonseca, J.E.; Carvalho, T.; Cruz, M.; Nero, P.; Sobral, M.; Mourão, A.F.; Cavaleiro, J.; et al. "Polymorphism at position -308 of the tumour factor a gene and rheumatoid arthritis pharmacogenetics". Annals of the Rheumatic Diseases 64 5 (2005): 793-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-20244363493&partnerID=MN8TOARS.
  72. Lindberg, A.; Gama-Carvallo, M.; Carmo-Fonseca, M.; Kreivi, J.-P.. "A single RNA recognition motif in splicing factor ASF/SF2 directs it to nuclear sites of adenovirus transcription". Journal of General Virology 85 3 (2004): 603-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642415943&partnerID=MN8TOARS.
  73. Custódio, N.; Carvalho, C.; Condado, I.; Antoniou, M.; Blencowe, B.J.; Carmo-Fonseca, M.. "In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei". RNA 10 4 (2004): 622-633. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644443879&partnerID=MN8TOARS.
  74. Berciano, M.T.; Villagra, N.T.; Ojeda, J.L.; Navascues, J.; Gomes, A.; Lafarga, M.; Carmo-Fonseca, M.. "Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus". Human Molecular Genetics 13 8 (2004): 829-838. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942485876&partnerID=MN8TOARS.
  75. Braga, J.; Rino, J.; Carmo-Fonseca, M.. "Photobleaching microscopy reveals the dynamics of mRNA-binding proteins inside live cell nuclei.". Progress in molecular and subcellular biology 35 (2004): 119-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342491600&partnerID=MN8TOARS.
  76. Pacheco, T.R.; Gomes, A.Q.; Barbosa-Morais, N.L.; Benes, V.; Ansorge, W.; Wollerton, M.; Smith, C.W.; Valcárcel, J.; Carmo-Fonseca, M.. "Diversity of vertebrate splicing factor U2AF35: Identification of alternatively spliced U2AF1 mRNAs". Journal of Biological Chemistry 279 26 (2004): 27039-27049. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042547158&partnerID=MN8TOARS.
  77. Braga, J.; Desterro, J.M.P.; Carmo-Fonseca, M.. "Intracellular macromolecular mobility measured by fluorescence recovery after photobleaching with confocal laser scanning microscopes". Molecular Biology of the Cell 15 10 (2004): 4749-4760. http://www.scopus.com/inward/record.url?eid=2-s2.0-4644243088&partnerID=MN8TOARS.
  78. Desterro, J.M.P.; Keegan, L.P.; Lafarga, M.; Berciano, M.T.; O'Connell, M.; Carmo-Fonseca, M.. "Dynamic association of RNA-editing enzymes with the nucleolus". Journal of Cell Science 116 9 (2003): 1805-1818. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038664237&partnerID=MN8TOARS.
  79. Gama-Carvalho, M.; Condado, I.; Carmo-Fonseca, M.. "Regulation of adenovirus alternative RNA splicing correlates with a reorganization of splicing factors in the nucleus". Experimental Cell Research 289 1 (2003): 77-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042663831&partnerID=MN8TOARS.
  80. Tavanez, J.P.; Cunha, C.; Silva, M.C.A.; David, E.; Monjardino, J.; Carmo-Fonseca, M.. "Hepatitis delta virus ribonucleoproteins shuttle between the nucleus and the cytoplasm". RNA 8 5 (2002): 637-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036252702&partnerID=MN8TOARS.
  81. Carmo-Fonseca, M.. "Understanding nuclear order". Trends in Biochemical Sciences 27 7 (2002): 332-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036629248&partnerID=MN8TOARS.
  82. Carmo-Fonseca, M.. "New clues to the function of the Cajal body". EMBO Reports 3 8 (2002): 726-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036668627&partnerID=MN8TOARS.
  83. Lafarga, M.; Berciano, M.T.; Pena, E.; Mayo, I.; Castaño, J.G.; Bohmann, D.; Rodrigues, J.P.; Tavanez, J.P.; Carmo-Fonseca, M.. "Clastosome: A subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome". Molecular Biology of the Cell 13 8 (2002): 2771-2782. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036678202&partnerID=MN8TOARS.
  84. Carmo-Fonseca, M.; Platani, M.; Swedlow, J.R.. "Macromolecular mobility inside the cell nucleus". Trends in Cell Biology 12 11 (2002): 491-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036849935&partnerID=MN8TOARS.
  85. Calapez, A.; Pereira, H.M.; Calado, A.; Braga, J.; Rino, J.; Carvalho, C.; Tavanez, J.P.; et al. "The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive". Journal of Cell Biology 159 5 (2002): 795-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037049650&partnerID=MN8TOARS.
  86. Carmo-Fonseca, M.. "The contribution of nuclear compartmentalization to gene regulation". Cell 108 4 (2002): 513-521. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037154983&partnerID=MN8TOARS.
  87. Gama-Carvalho, M.; Carvalho, M.P.; Kehlenbach, A.; Valcárcel, J.; Carmo-Fonseca, M.. "Nucleocytoplasmic Shuttling of Heterodimeric Splicing Factor U2AF". Journal of Biological Chemistry 276 16 (2001): 13104-13112. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035918266&partnerID=MN8TOARS.
  88. Vautier, D.; Chesné, P.; Cunha, C.; Calado, A.; Renard, J.-P.; Carmo-Fonseca, M.. "Transcription-dependent nucleocytoplasmic distribution of hnRNP A1 protein in early mouse embryos". Journal of Cell Science 114 8 (2001): 1521-1531. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035024461&partnerID=MN8TOARS.
  89. Gama-Carvalho, M.; Carmo-Fonseca, M.. "The rules and roles of nucleocytoplasmic shuttling proteins". FEBS Letters 498 2-3 (2001): 157-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035827321&partnerID=MN8TOARS.
  90. Mühlemann, O.; Mock-Casagrande, C.S.; Wang, J.; Li, S.; Custódio, N.; Carmo-Fonseca, M.; Wilkinson, M.F.; Moore, M.J.. "Precursor RNAs harboring nonsense codons accumulate near the site of transcription". Molecular Cell 8 1 (2001): 33-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034886974&partnerID=MN8TOARS.
  91. Galvão, R.; Mendes-Soares, L.; Câmara, J.; Jaco, I.; Carmo-Fonseca, M.. "Triplet repeats, RNA secondary structure and toxic gain-of-function models for pathogenesis". Brain Research Bulletin 56 3-4 (2001): 191-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035503902&partnerID=MN8TOARS.
  92. Custödio, N.; Carmo-Fonseca, M.. "Quality control of gene expression in the nucleus". Journal of Cellular and Molecular Medicine 5 3 (2001): 267-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035527330&partnerID=MN8TOARS.
  93. Carvalho, C.; Pereira, H.M.; Ferreira, J.; Pina, C.; Mendonça, D.; Rosa, A.C.; Carmo-Fonseca, M.. "Chromosomal G-dark bands determine the spatial organization of centromeric heterochromatin in the nucleus". Molecular Biology of the Cell 12 11 (2001): 3563-3572. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035200784&partnerID=MN8TOARS.
  94. Rodrigues, J.P.; Rode, M.; Gatfield, D.; Blencowe, B.J.; Carmo-Fonseca, M.; Izaurralde, E.. "REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus". Proceedings of the National Academy of Sciences of the United States of America 98 3 (2001): 1030-1035. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035970063&partnerID=MN8TOARS.
  95. Calado, A.; Kutay, U.; Kühn, U.; Wahle, E.; Carmo-Fonseca, M.. "Deciphering the cellular pathway for transport of poly(A)-binding protein II". RNA 6 2 (2000): 245-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033951076&partnerID=MN8TOARS.
  96. Calado, A.; Carmo-Fonseca, M.. "Localization of poly(A)-binding protein 2 (PABP2) in nuclear speckles is independent of import into the nucleus and requires binding to poly(A) RNA". Journal of Cell Science 113 12 (2000): 2309-2318. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033920763&partnerID=MN8TOARS.
  97. Jordan, P.; Carmo-Fonseca, M.. "Molecular mechanisms involved in cisplatin cytotoxicity". Cellular and Molecular Life Sciences 57 8-9 (2000): 1229-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033841622&partnerID=MN8TOARS.
  98. Calado, A.; Tomé, F.M.S.; Brais, B.; Rouleau, G.A.; Kühn, U.; Wahle, E.; Carmo-Fonseca, M.. "Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA". Human Molecular Genetics 9 15 (2000): 2321-2328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034703413&partnerID=MN8TOARS.
  99. Herold, A.; Suyama, M.; Rodrigues, J.P.; Braun, I.C.; Kutay, U.; Carmo-Fonseca, M.; Bork, P.; Izaurralde, E.. "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology 20 23 (2000): 8996-9008. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034460814&partnerID=MN8TOARS.
  100. Kutay, U.; Hartmann, E.; Treichel, N.; Calado, A.; Carmo-Fonseca, M.; Prehn, S.; Kraft, R.; Görlich, D.; Bischoff, F.R.. "Identification of two novel RanGTP-binding proteins belonging to the importin ß superfamily". Journal of Biological Chemistry 275 51 (2000): 40163-40168. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034704091&partnerID=MN8TOARS.
  101. Von Kobbe, C.; Van Deursen, J.M.A.; Rodrigues, J.P.; Sitterlin, D.; Bachi, A.; Wu, X.; Wilm, M.; Carmo-Fonseca, M.; Izaurralde, E.. "Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98". Molecular Cell 6 5 (2000): 1243-1252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033636997&partnerID=MN8TOARS.
  102. Carmo-Fonseca, M.; Mendes-Soares, L.; Campos, I.. "To be or not to be in the nucleolus". Nature Cell Biology 2 6 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0033782013&partnerID=MN8TOARS.
  103. Bachi, A.; Braun, I.C.; Rodrigues, J.P.; Panté, N.; Ribbeck, K.; Von Kobbe, C.; Kutay, U.; et al. "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates". RNA 6 1 (2000): 136-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044441683&partnerID=MN8TOARS.
  104. Custódio, N.; Carmo-Fonseca, M.; Geraghty, F.; Pereira, H.S.; Grosveld, F.; Antoniou, M.. "Inefficient processing impairs release of RNA from the site of transcription". EMBO Journal 18 10 (1999): 2855-2866. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041013167&partnerID=MN8TOARS.
  105. Schmitt, C.; Von Kobbe, C.; Bachi, A.; Panté, N.; Rodrigues, J.P.; Boscheron, C.; Rigaut, G.; et al. "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO Journal 18 15 (1999): 4332-4347. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033517108&partnerID=MN8TOARS.
  106. Carvalho, T.; Almeida, F.; Calapez, A.; Lafarga, M.; Berciano, M.T.; Carmo-Fonseca, M.. "The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body". Journal of Cell Biology 147 4 (1999): 715-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571601&partnerID=MN8TOARS.
  107. Carmo-Fonseca, M.; Custódio, N.; Calado, A.. "Intranuclear trafficking of messenger RNA". Critical Reviews in Eukaryotic Gene Expression 9 3-4 (1999): 213-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342948918&partnerID=MN8TOARS.
  108. Almeida, F.; Saffrich, R.; Ansorge, W.; Carmo-Fonseca, M.. "Microinjection of anti-coilin antibodies affects the structure of coiled bodies". Journal of Cell Biology 142 4 (1998): 899-912. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032563559&partnerID=MN8TOARS.
  109. Lafarga, M.; Berciano, M.T.; Garcia-Segura, L.M.; Andres, M.A.; Carmo-Fonseca, M.. "Acute osmotic/stress stimuli induce a transient decrease of transcriptional activity in the neurosecretory neurons of supraoptic nuclei". Journal of Neurocytology 27 4 (1998): 205-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031667098&partnerID=MN8TOARS.
  110. Cunha, C.; Monjardino, J.; Chang, D.; Krause, S.; Carmo-Fonseca, M.. "Localization of hepatitis delta virus RNA in the nucleus of human cells". RNA 4 6 (1998): 680-693. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031799296&partnerID=MN8TOARS.
  111. Jordan, P.; Carmo-Fonseca, M.. "Cisplatin inhibits synthesis of ribosomal RNA in vivo". Nucleic Acids Research 26 12 (1998): 2831-2836. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032526319&partnerID=MN8TOARS.
  112. Ferreira, J.; Carmo-Fonseca, M.. "Genome replication in early mouse embryos follows a defined temporal and spatial order". Journal of Cell Science 110 7 (1997): 889-897. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030964894&partnerID=MN8TOARS.
  113. Gama-Carvalho, M.; Krauss, R.D.; Chiang, L.; Valcárcel, J.; Green, M.R.; Carmo-Fonseca, M.. "Targeting of U2AF65 to sites of active splicing in the nucleus". Journal of Cell Biology 137 5 (1997): 975-987. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030612083&partnerID=MN8TOARS.
  114. Jordan, P.; Cunha, C.; Carmo-Fonseca, M.. "The cdk7-cyclin H-MAT1 complex associated with TFIIH is localized in coiled bodies". Molecular Biology of the Cell 8 7 (1997): 1207-1217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030793104&partnerID=MN8TOARS.
  115. Lafarga, M.; Berciano, M.T.; Carmo-Fonseca, M.. "Semithin cryosections as a tool to perform high resolution immunofluorescence and in situ hybridization analysis of the nervous tissue: A study in the supraoptic nucleus". Journal of Neuroscience Methods 75 2 (1997): 137-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030788071&partnerID=MN8TOARS.
  116. Parreira, L.; Telhada, M.; Ramos, C.; Hernandez, R.; Neves, H.; Carmo-Fonseca, M.. "The spatial distribution of human immunoglobulin genes within the nucleus: Evidence for gene topography independent of cell type and transcriptional activity". Human Genetics 100 5-6 (1997): 588-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031431812&partnerID=MN8TOARS.
  117. Carmo-Fonseca, M.; Cunha, C.; Custódio, N.; Carvalho, C.; Jordan, P.; Ferreira, J.; Parreira, L.. "The topography of chromosomes and genes in the nucleus". Experimental Cell Research 229 2 (1996): 247-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030589487&partnerID=MN8TOARS.
  118. Pereira Da Silva, J.A.; Fonseca, J.E.; Graca, L.; Moita, L.; Carmo-Fonseca, M.. "Reinnervation of post-arthritis joints in the rat". Clinical and Experimental Rheumatology 14 1 (1996): 43-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029878532&partnerID=MN8TOARS.
  119. Elefanty, A.G.; Antoniou, M.; Custodio, N.; Carmo-Fonseca, M.; Grosveld, F.G.. "GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes". EMBO Journal 15 2 (1996): 319-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030068286&partnerID=MN8TOARS.
  120. Jordan, P.; Mannervik, M.; Tora, L.; Carmo-Fonseca, M.. "In vivo evidence that TATA-binding protein/SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive". Journal of Cell Biology 133 2 (1996): 225-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029914626&partnerID=MN8TOARS.
  121. Rebelo, L.; Almeida, F.; Ramos, C.; Bohmann, K.; Lamond, A.I.; Carmo-Fonseca, M.. "The dynamics of coiled bodies in the nucleus of adenovirus-infected cells". Molecular Biology of the Cell 7 7 (1996): 1137-1151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030035435&partnerID=MN8TOARS.
  122. Ferreira, J.; Carmo-Fonseca, M.. "Nuclear morphogenesis and the onset of transcriptional activity in early hamster embryos". Chromosoma 105 1 (1996): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029935963&partnerID=MN8TOARS.
  123. Ding, H.; Descheemaeker, K.; Maryncn, P.; Nellcs, L.; Carvalho, T.; Carmo-Fonseca, M.; Collen, D.; Belayew, A.. "A helicase-Like transcription factor is involved in the basal expression of the human pai-1 gene. II 214". Fibrinolysis 10 SUPPL. 3 (1996): http://www.scopus.com/inward/record.url?eid=2-s2.0-33846666039&partnerID=MN8TOARS.
  124. Telhada, M.; Carvalho, C.; Carmo-Fonseca, M.; Parreira, L.. "Influence of transcription and replication on the in situ resolution of immunoglobulin heavy-chain constant region genes: An interphase cytogenetics analysis". Human Genetics 96 5 (1995): 552-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028844517&partnerID=MN8TOARS.
  125. Bridge, E.; Xia, D.-X.; Carmo-Fonseca, M.; Cardinali, B.; Lamond, A.I.; Pettersson, U.. "Dynamic organization of splicing factors in adenovirus-infected cells". Journal of Virology 69 1 (1995): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028970384&partnerID=MN8TOARS.
  126. Ferreira, J.; Carmo-Fonseca, M.. "The biogenesis of the coiled body during early mouse development". Development 121 2 (1995): 601-612. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028911499&partnerID=MN8TOARS.
  127. Leite, R.P.; Carmo-Fonseca, M.; Cabecadas, J.; Parreira, A.; Parreira, L.. "Differential expression of cell adhesion molecules in the functional compartments of lymph nodes and tonsils". Journal of Clinical Pathology - Clinical Molecular Pathology 48 2 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028923992&partnerID=MN8TOARS.
  128. Carvalho, T.; Seeler, J.-S.; Ohman, K.; Jordan, P.; Pettersson, U.; Akusjarvi, G.; Carmo-Fonseca, M.; Dejean, A.. "Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix- associated PML bodies". Journal of Cell Biology 131 1 (1995): 45-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029100611&partnerID=MN8TOARS.
  129. Pombo, A.; Carmo-Fonseca, M.. "Interactions of adenovirus with the nucleus of the host cell". Reviews in Medical Virology 5 4 (1995): 213-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029551511&partnerID=MN8TOARS.
  130. Pombo, A.; Ferreira, J.; Bridge, E.; Carmo-Fonseca, M.. "Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells". EMBO Journal 13 21 (1994): 5075-5085. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028092203&partnerID=MN8TOARS.
  131. Weis, K.; Rambaud, S.; Lavau, C.; Jansen, J.; Carvalho, T.; Carmo-Fonseca, M.; Lamond, A.; Dejeant, A.. "Retinoic acid regulates aberrant nuclear localization of PML-RARa in acute promyelocytic leukemia cells". Cell 76 2 (1994): 345-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028158682&partnerID=MN8TOARS.
  132. Ferreira, J.A.; Carmo-Fonseca, M.; Lamond, A.I.. "Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei". Journal of Cell Biology 126 1 (1994): 11-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028337641&partnerID=MN8TOARS.
  133. Blencowe, B.J.; Carmo-Fonseca, M.; Behrens, S.-E.; Luhrmann, R.; Lamond, A.I.. "Interaction of the human autoantigen p150 with splicing snRNPs". Journal of Cell Science 105 3 (1993): 685-697. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027283078&partnerID=MN8TOARS.
  134. Bridge, E.; Carmo-Fonseca, M.; Lamond, A.; Pettersson, U.. "Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells". Journal of Virology 67 10 (1993): 5792-5802. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027267614&partnerID=MN8TOARS.
  135. Carmo-Fonseca, M.; Ferreira, J.; Lamond, A.I.. "Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis - Evidence that the coiled body is a kinetic nuclear structure". Journal of Cell Biology 120 4 (1993): 841-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027389169&partnerID=MN8TOARS.
  136. Lamond, A.I.; Carmo-Fonseca, M.. "Localisation of splicing snRNPs in mammalian cells". Molecular Biology Reports 18 2 (1993): 127-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027651654&partnerID=MN8TOARS.
  137. Phelan, A.; Carmo-Fonseca, M.; McLauchlan, J.; Lamond, A.I.; Clements, J.B.. "A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution". Proceedings of the National Academy of Sciences of the United States of America 90 19 (1993): 9056-9060. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027424652&partnerID=MN8TOARS.
  138. Lamond, A.I.; Carmo-Fonseca, M.. "The coiled body". Trends in Cell Biology 3 6 (1993): 198-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027273980&partnerID=MN8TOARS.
  139. Antoniou, M.; Carmo-Fonseca, M.; Ferreira, J.; Lamond, A.I.. "Nuclear organization of splicing snRNPs during differentiation of murine erythroleukemia cells in vitro". Journal of Cell Biology 123 5 (1993): 1055-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027383759&partnerID=MN8TOARS.
  140. Zhang, M.; Zamore, P.D.; Carmo-Fonseca, M.; Lamond, A.I.; Green, M.R.. "Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit". Proceedings of the National Academy of Sciences of the United States of America 89 18 (1992): 8769-8773. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026649523&partnerID=MN8TOARS.
  141. Hurt, E.C.; Mutvei, A.; Carmo-Fonseca, M.. "The nuclear envelope of the yeast Saccharomyces cerevisiae". International Review of Cytology 136 (1992): 145-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026665536&partnerID=MN8TOARS.
  142. Rebelo, L.; Carmo-Fonseca, M.; Fonseca Moura, T.. "Redistribution of microvilli and membrane enzymes in isolated rat proximal tubule cells". Biology of the Cell 74 2 (1992): 203-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026529989&partnerID=MN8TOARS.
  143. Carmo-Fonseca, M.; Pepperkok, R.; Carvalho, M.T.; Lamond, A.I.. "Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies". Journal of Cell Biology 117 1 (1992): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026528445&partnerID=MN8TOARS.
  144. Jansen, R.P.; Hurt, E.C.; Kern, H.; Lehtonen, H.; Carmo-Fonseca, M.; Lapeyre, B.; Tollervey, D.. "Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast". Journal of Cell Biology 113 4 (1991): 715-729. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025850639&partnerID=MN8TOARS.
  145. Carmo-Fonseca, M.; Pepperkok, R.; S.sproat, B.; Ansorge, W.; S.swanson, M.; I.lamond, A.. "In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells". EMBO Journal 10 7 (1991): 1863-1873. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025898426&partnerID=MN8TOARS.
  146. Carmo-Fonseca, M.; Tollervey, D.; Pepperkok, R.; Barabino, S.M.L.; Merdes, A.; Brunner, C.; Zamore, P.D.; et al. "Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery". EMBO Journal 10 1 (1991): 195-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026069583&partnerID=MN8TOARS.
  147. Tollervey, D.; Lehtonen, H.; Carmo-Fonseca, M.; C.hurt, E.. "The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast". EMBO Journal 10 3 (1991): 573-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025963863&partnerID=MN8TOARS.
  148. Plancha, C.E.; Carmo-Fonseca, M.; David-Ferreira, J.F.. "Cytokeratin in early hamster embryogenesis and parthenogenesis: Reorganization during mitosis and association with clusters of interchromatinlike granules". Differentiation 48 2 (1991): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025943909&partnerID=MN8TOARS.
  149. Carmo-Fonseca, M.; Hurt, E.C.. "Across the nuclear pores with the help of nucleoporins". Chromosoma 101 4 (1991): 199-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025719031&partnerID=MN8TOARS.
  150. Carmo-Fonseca, M.; Kern, H.; Hurt, E.C.. "Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization". European Journal of Cell Biology 55 1 (1991): 17-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025886328&partnerID=MN8TOARS.
  151. Carmo-Fonseca, M.. "Intracellular recognition mechanisms. Physiopathologic implications | Mecanismos de reconhecimento intracelular. Implicações fisiopatológicas.". Acta medica portuguesa 3 1 (1990): 43-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024985220&partnerID=MN8TOARS.
  152. Pereira da Silva, J.A.; Carmo-Fonseca, M.. "Peptide containing nerves in human synovium: Immunohistochemical evidence for decreased innervation in rheumatoid arthritis". Journal of Rheumatology 17 12 (1990): 1592-1599. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025690402&partnerID=MN8TOARS.
  153. Carmo-Fonseca, M.; David-Ferreira, J.F.. "Interactions of intermediate filaments with cell structures". Electron Microscopy Reviews 3 1 (1990): 115-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025669849&partnerID=MN8TOARS.
  154. Schroder, H.C.; Falke, D.; Weise, K.; Bachmann, M.; Carmo-Fonseca, M.; Zaubitzer, T.; Muller, W.E.G.. "Change of processing and nucleocytoplasmic transport of mRNA in HSV-1-infected cells". Virus Research 13 1 (1989): 61-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024338414&partnerID=MN8TOARS.
  155. Carmo-Fonseca, M.; Vaz, Y.. "Immunocytochemical localization and lectin-binding properties of the 22 kDa secretory protein from rat ventral prostate". Biology of Reproduction 40 1 (1989): 153-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024581116&partnerID=MN8TOARS.
  156. Carmo-Fonseca, M.; Pfeifer, K.; Schroder, H.C.; Vaz, M.F.; Fonseca, J.E.; Muller, W.E.G.; Bachmann, M.. "Identification of La ribonucleoproteins as a component of interchromatin granules". Experimental Cell Research 185 1 (1989): 73-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024792810&partnerID=MN8TOARS.
  157. Plancha, C.E.; Carmo-Fonseca, M.; David-Ferreira, J.F.. "Cytokeratin filaments are present in golden hamster oocytes and early embryos". Differentiation 42 1 (1989): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024791843&partnerID=MN8TOARS.
  158. Carmo-Fonseca, M.; Cidadão, A.J.; David-Ferreira, J.F.. "Filamentous cross-bridges link intermediate filaments to the nuclear pore complexes.". European Journal of Cell Biology 45 2 (1988): 282-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023953897&partnerID=MN8TOARS.
  159. Carmo-Fonseca, M.. "Androgen-dependent nuclear proteins in rat ventral prostate are glycoproteins associated with the nuclear matrix". Cell Biology International Reports 12 8 (1988): 607-620. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024062424&partnerID=MN8TOARS.
  160. Carmo-Fonseca, M.. "Nuclear compactness as assessed by ferritin permeation: A critical evaluation of the method". Journal of Ultrastructure and Molecular Structure Research 101 1 (1988): 4-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024146877&partnerID=MN8TOARS.
  161. Carmo-Fonseca, M.. "Quantitative ultrastructural autoradiographic study of RNA transport in rat ventral prostate". Journal of Ultrastructure and Molecular Structure Research 94 1 (1986): 63-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023006251&partnerID=MN8TOARS.
  162. Carmo-Fonseca, M.; David-Ferreira, J.F.. "Different patterns of filipin-sterol labeling in prostate nuclear membranes from normal and castrated rats". Cell Biology International Reports 9 1 (1985): 69-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021944701&partnerID=MN8TOARS.
  163. Pedro, N.; Carmo-Fonseca, M.; Fernands, P.. "Quantitative analysis of pore patterns on rat prostate nuclei using spatial statistics methods". Journal of Microscopy 134 3 (1984): 271-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021237695&partnerID=MN8TOARS.
  164. Arnold, C.; Gulbenkian, S.; Carmo Fonseca, M.; David Ferreira, J.F.. "Androgen-dependent changes in nuclear ultrastructure. A stereological study on rat ventral prostate and seminal vesicle". Biology of the Cell 47 2 (1983): 161-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020530799&partnerID=MN8TOARS.
  165. Carmo-Fonseca, M.. "Testosterone-induced changes in nuclear pore complex number of prostatic nuclei from castrated rats". Journal of Ultrastructure Research 80 2 (1982): 243-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020376696&partnerID=MN8TOARS.
  166. Carmo-Fonseca, M.; David-Ferreira, J.F.. "Quantitative study of nuclear pore complexes in ventral prostate isolated nuclei from intact and castrated rats". Journal of Ultrastructure Research 76 2 (1981): 202-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019821429&partnerID=MN8TOARS.
Edição de número de revista
  1. "Transcription and splicing dynamics during early Drosophila development". RNA 28 2 (2022): PMID: 34667107.
Tese / Dissertação
  1. Dias, Inês Isabel Vendrell Vidal. "Detection of actionable mutations in ctDNA in advanced breast cancer patients". Mestrado, 2019. http://hdl.handle.net/10451/39454.
  2. Oliveira, Inês Domingues. "Detection of BRAF V600E mutation in ctDNA by ddPCR: from laboratory to market". Mestrado, 2018. http://hdl.handle.net/10362/53897.
  3. Almeida, Rita Mingot de Almeida Mendes de. "Exploring new biological frontiers in hypertrophic cardiomyopathy". Doutoramento, 2018. http://hdl.handle.net/10451/34418.
  4. Drago, Rita Catarina Vaz. "Co-transcriptional quality control of mRNA biogenesis : impact for human genetic diseases". Doutoramento, 2018. http://hdl.handle.net/10451/37217.
  5. Rebelo, Kenny Patrick Figueira. "Splicing kinetics revealed by nascent transcript sequencing". Mestrado, 2017. http://hdl.handle.net/10451/28305.
  6. Viegas, Inês Correia. "Identifying the sequence complexity of miRNAs and their functional impact in small-RNA-seq data". Mestrado, 2017. http://hdl.handle.net/10451/32636.
  7. Silva, Soraia Vanessa Guerreiro da. "Epigenetics and alternative splicing". Mestrado, 2016. http://hdl.handle.net/10400.1/8419.
  8. Franco, António Duarte Zapico Bicho de Sousa. "Long non-coding RNA contributes to direct conversion reprogramming". Mestrado, 2016. http://hdl.handle.net/10362/19464.
  9. Mollet, Inês Maria de Stoop Camões Teixeira Guerra, 1966-. "Genome wide mining of alternative splicing in metazoan model organisms". Doutoramento, 2009. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000554004.
  10. Custódio, Noélia Maria Fernandes, 1971-. "Quality control of gene expression in the mammalian cell nucleus". Doutoramento, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000532476.
  11. Ferreira, Fernando António da Costa. "Distribuição nuclear, dinâmica e função das topoisomerases I, IIa e IIß na replicação de genomas : estudo experimental no adenovírus serótipo 2-". Doutoramento, 2008. http://hdl.handle.net/10400.5/224.


Outra produção
  1. POINT Technology Illuminates the Processing of Polymerase-Associated Intact Nascent Transcripts. 2020. Rui Sousa-Luis; Gwendal Dujardin; Inna Zukher; Hiroshi Kimura; Maria Carmo-Fonseca; Nick J Proudfoot; Takayuki Nojima. https://doi.org/10.1101/2020.11.09.374108.

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/09/09 Keynote: Co-transcriptional splicing RNA Informatics
Wellcome Genome Campus (Hinxton, Cambridge, Reino Unido)
2019/07/23 Invited: Single-molecule live-cell imaging of mRNA life cycle Biophysics Congress
(Madrid, Espanha)
2019/07/03 Invited: Splicing kinetics The RNA localization and local translation conference
(Snowmass Village, CO, Estados Unidos)
2019/06/14 Keynote: The timing of splicing Annual Meeting of the RNA Society
RNA Society (Kraków, Polónia)
2018/11/27 Invited: RNA-mediated transcriptional control in stemness, oncogenesis and aging: Tailored disease treatments “Systems Epigenetics: towards precision cancer medicine”
(Amsterdam, Países Baixos)
2018/03/29 Invited: How is transcription coupled to RNA splicing? Invited seminar at Institut Pasteur
Institut Pasteur (Paris, França)
2018/03/07 Invited: Making sense of antisense RNA “RNA: beyond its genetic code”
University of Cologne (Cologne, Alemanha)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual RNA (1469-9001) Cold Spring Harbor Laboratory
2009 - Atual Journal of Cell Science (1477-9137) The Company of Biologists

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2019/09/01 - 2019/10/30 Chaired the Jury for the Bial Award in Biomedicine 2019 Fundação Bial
2018 - 2018 FEBS Letters Award Committee

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019/11/22 - Atual Member of the Scientific Advisory Board for Fundação Bial Fundação Bial, Portugal
2019/10/29 - Atual Member of the Advisory Board for Lusíadas Saúde, S.A. Lusíadas Saúde, S.A., Portugal


2019 Prémio Aboim Sande Lemos-Identidade Portuguesa
Sociedade Histórica da Independência de Portugal, Portugal
2013 Prémio D. Antónia Ferreira (Portuguese award for Entrepreneurial women)
Sogrape vinhos S.A., Portugal
2010 Prémio Pessoa
Expresso e Caixa Geral de Depósitos, Portugal
2007 Prémio Gulbenkian de Ciência
2002 Prémio Pfizer de Investigação
Sociedade das Ciências Médicas, Portugal
2002 Iberian DuPont Science Award
Dupont Espana, Espanha
1993 José Sala-Trepat Prize
Fondation de France/Institut Pasteur, França


2001 Comenda Ordem de Sant’iago de Espada Ilustres Carreira
Presidência da República Portuguesa, Portugal
1994 EMBO Member