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RS received her PhD in Medicine from the Medical Faculty of Porto in 1995. RS PhD project aimed to study the role of diverse oncogenes and tumour supressor genes in the progression of gastric cancer, and identified, for the first time, microsatellite instability (MSI) and MMR repair alterations as a particular molecular subtype of gastric cancer. This work brought RS international recognition in the field of genetics of gastric cancer and stomach related diseases. Further, in colorectal cancer, she addressed the clinical importance of MSI, target genes and oncogenic mutations and established a model of development of BRAF and KRAS associated colorectal carcinomas. In the setting of highly invasive cancers, namely stomach cancer, RS has been involved in determining the importance of cell-cell, cell-matrix interactions and signalling of invasive cancer cells, and how these events promote cancer invasion and metastization. For that purpose, she uses the paradigm model of isolated invasion associated to HDGC (hereditary diffuse gastric cancer) which is mediated by loss of E-cadherin function, a key epithelial marker that is frequently lost in invasive cancer cells with high potential for distant metastization. Due to the work developed throughout her career, RS is regarded as a worldwide expert on cancer cell invasion, namely in gastric and colon cancers. In the context of HDGC, RS is an international reference and a Member of the International Gastric Cancer Linkage Consortium that defines the guidelines for management of patients and families carrying E-cadherin germline mutations. In this context, Seruca´s lab is a worldwide Reference Center in the functional analysis of E-cadherin missense mutations, with a tremendous impact in the clinical surveillance of carriers. Attesting her international recognition and expertise in functional assays for germline sequence variants of E-cadherin, RS has been invited to be a Member of the Scientific Advisory Council of the American Association ¿No Stomach for Cancer¿ that supports families with gastric cancer. RS maintains an international collaborative network with oncologists, pathologists, geneticists, cell biologists, biochemists, surgeons, and bioengineers, and has been involved in developing new bioimaging tools and novel strategies with application to diagnosis and treatment stratification of invasive cancer. In 2009, Raquel Seruca received the distinction ¿Ordem do Infante D. Henrique¿ from the Portuguese Presidency for her Scientific merit, reflecting the recognition of her contribution to research and outreach activities in Portugal. Likewise, in 2014, RS was awarded ¿Medalha de Ouro de Mérito Cientifico¿ by Câmara Municipal do Porto. More recently, in 2018, RS was invited to be a Member of the installing committee of ¿Agência para a Investigação Clínica e Inovação Biomédica - AICIB¿, demonstrative of her visibility in Portugal. Importantly, RS coordinates the Porto. Comprehensive Cancer Centre, a consortium dedicated to the prevention, diagnosis, and innovation in the treatment of cancer. As Principal investigator (PI), RS has been able to raise more than 1.5 million euros, excluding her salary, under competitive funding calls from FCT, NHI and Europe. Raquel Seruca has 263 publications in international peer-reviewed journals with an h-index of 67 (Scopus). RS has publications in TOP journals of her research area: Gastroenterology, Lancet Oncology, New England Journal of Medicine, Human Molecular Genetics, Oncogene, Gut, European Journal of Human Genetics, Scientific Reports, Molecular Cancer.
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Identificação

Identificação pessoal

Nome completo
Raquel Seruca

Nomes de citação

  • Seruca, Raquel

Identificadores de autor

Ciência ID
AF16-3243-F4EF
ORCID iD
0000-0002-8851-4166
Scopus Author Id
7006207833

Moradas

  • i3S - Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
1995
Concluído
 Doutoramento em Medicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
 Muito Bom por unaminidade
1986
Concluído
 Licenciatura em Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 14 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Investigador Coordenador (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2000 - 2015 Investigador Coordenador (carreira) (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999 - 2000 Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006 - Atual Professor Associado Convidado (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2010 - Atual Vice-Presidente Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1999 - Atual Member of the International Gastric Cancer Linkage Consortium International Gastric Cancer Linkage Consortium, Reino Unido
2015 - 2019 Coordinator of Cancer Integrative Program Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
1998 - 1999 Post-Doctoral fellow Rijksuniversiteit Groningen, Países Baixos
Rijksuniversiteit Groningen, Países Baixos
1995 - 1998 Post-Doctoral fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03 - 2024/02 Nuclear biomarkers for predictive prognosis of hereditary diffuse gastric cancer
NICE
Investigador responsável
No Stomach for Cancer, Inc, Estados Unidos
 No Stomach for Cancer, Inc
Em curso
2018 - 2021 CAPTURE - Mechanodependent capture of circulating tumour cells: a cell-ECM based approach coupled with cancer specific glycomarkers
PTDC/BTM-SAL/30383/2017
 Fundação para a Ciência e a Tecnologia
2018 - 2021 E-RISK - Oral facial congenital malformations and gastric cancer risk: a matter of E-cadherin mediated cell-extracellular matrix adhesion
PTDC/MED/GEN/30356/2017
 Fundação para a Ciência e a Tecnologia
2017 - 2019 STOMACH - Today´s present, Tomorrow´s future on the study of germline E-cadherin missense mutations: A step forward on providing informed genetic counselling to everyone
STOMACH
 No Stomach for Cancer, Inc
2016 - 2019 TRACE-Tracing gastric cancer using quantitative bioimaging analysis
PTDC/BBB-IMG/0283/2014
 Fundação para a Ciência e a Tecnologia
2016 - 2019 E-cadherin loss in the process of cell invasion in cancer
NORTE-01-0145-FEDER-000029
 NORTE 2020
2016/01 - 2018/12 Sensing dysfunctional E-cadherin cells in gastric epithelia (SENSE)
Provided by PTCRIS: 138871
 Fundação para a Ciência e a Tecnologia
2015 - 2017 MISS - Today´s present, tomorrow´s future on the study of germline E-cadherin missense mutations
MISS
 No Stomach for Cancer, Inc
2014/01 - 2015/12 Incentive - LA 3 - 2014
Provided by PTCRIS: 137387
 Fundação para a Ciência e a Tecnologia
2013/06 - 2015/09 Mutant E-Cadherin and Novel Interactors in Cancer (MECANIC). The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer.
Provided by PTCRIS: 124283
 Fundação para a Ciência e a Tecnologia
2013 - 2015 Molecular mechanisms underlying cancer cell invasion in two disease models, gastric and breast
NORTE-07-0124-FEDER-000022
 ON - Novo Norte; FEDER; Programa Operacional Regional do Norte
2011/04 - 2014/09 Tumour spectrum in Hereditary Diffuse Gastric Cancer
Provided by PTCRIS: 110294
 Fundação para a Ciência e a Tecnologia
2010/06 - 2013/11 The role of Protein Quality Control in the regulation of E-cadherin and its relevance in cancer.
Provided by PTCRIS: 104017
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/06 Bacterial protein azurin as a new candidate drug to treat poor-prognosis breast cancer
Provided by PTCRIS: 100326
 Fundação para a Ciência e a Tecnologia
2009/01 - 2012/07 Exploring the role of E-Cadherin-HER interaction in the search of molecular biomarkers for the clinical management of gastric cancer patients
Provided by PTCRIS: 82923
 Fundação para a Ciência e a Tecnologia
2009/01 - 2011/12 Implementation of a Nacional Facility for DNA Microarrays: Phase II
Provided by PTCRIS: 64745
 Fundação para a Ciência e a Tecnologia
2008/07 - 2011/12 MLK3, a new mutated gene in MSI colorectal cancer
Provided by PTCRIS: 68310
 Fundação para a Ciência e a Tecnologia
2008/02 - 2011/04 Exploring the role of E-cadherin trafficking deregulation in epithelial cancer progression.
Provided by PTCRIS: 64319
 Fundação para a Ciência e a Tecnologia
2007/08 - 2010/12 Targeting nanoprobes for early detection of invasive cancer cells using Hereditary Diffuse Gastric Cancer as a model
Provided by PTCRIS: 69901
 Fundação para a Ciência e a Tecnologia
2007/08 - 2010/11 Papel de novos mechanismos regulatórios na perda de expressão da caderina-E
Provided by PTCRIS: 72168
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/08 Functional analysis of the E-cadherin repressors (Slug, ZEB1 and E12/E47) in gastric cancer
Provided by PTCRIS: 57275
 Fundação para a Ciência e a Tecnologia
2005/07 - 2008/06 In mismatch repair deficiency colorectal cancer are BRAF and KRAS new prognostic and therapeutic tools?
Provided by PTCRIS: 56921
 Fundação para a Ciência e a Tecnologia
2005/07 - 2008/06 Identification of molecular mechanisms underlying gastric cancer in families positive and negative for E-cadherin germline mutations
Provided by PTCRIS: 58111
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/01 E-cadherin germline missense mutations and hereditary diffuse gastric cancer: a model for the identification of the E-cadherin-dependent signaling pathways pivotal for cell invasion
Provided by PTCRIS: 57670
 Fundação para a Ciência e a Tecnologia
2004/07 - 2004/12 E-cadherin germline missense mutations and hereditary diffuse gastric cancer: a model for the identification of the E-cadherin-dependent signaling pathways pivotal for cell invasion
e27529af1f582d20e4da2e76e4a9ff9e
 Terry Fox Foundation
Produções

Publicações

Artigo em revista
  1. Figueiredo, J.; Ferreira, R.M.; Xu, H.; Gonçalves, M.; Barros-Carvalho, A.; Cravo, J.; Maia, A.F.; et al. "Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells". Gastric Cancer 25 1 (2022): 124-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114350265&partnerID=MN8TOARS.
    10.1007/s10120-021-01239-9
  2. Ringborg, U.; Berns, A.; Celis, J.E.; Heitor, M.; Tabernero, J.; Schüz, J.; Baumann, M.; et al. "The Porto European Cancer Research Summit 2021". Molecular Oncology 15 10 (2021): 2507-2543. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114897969&partnerID=MN8TOARS.
    10.1002/1878-0261.13078
  3. Figueiredo, J.; Mercadillo, F.; Melo, S.; Barroso, A.; Gonçalves, M.; Díaz-Tasende, J.; Carneiro, P.; et al. "Germline cdh1 g212e missense variant: Combining clinical, in vitro and in vivo strategies to unravel disease Burden". Cancers 13 17 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113807006&partnerID=MN8TOARS.
    10.3390/cancers13174359
  4. Narotamo, H.; Fernandes, M.S.; Moreira, A.M.; Melo, S.; Seruca, R.; Silveira, M.; Sanches, J.M.. "A machine learning approach for single cell interphase cell cycle staging". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116364785&partnerID=MN8TOARS.
    10.1038/s41598-021-98489-5
  5. Moreira, Ana Margarida; Pereira, Joana; Melo, Soraia; Fernandes, Maria Sofia; Carneiro, Patrícia; Seruca, Raquel; Figueiredo, Joana. "The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression". Cells 9 2 (2020): 394. http://dx.doi.org/10.3390/cells9020394.
    Publicado • 10.3390/cells9020394
  6. Blair, V.R.; McLeod, M.; Carneiro, F.; Coit, D.G.; D'Addario, J.L.; van Dieren, J.M.; Harris, K.L.; et al. "Hereditary diffuse gastric cancer: updated clinical practice guidelines". The Lancet Oncology 21 8 (2020): e386-e397. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088930288&partnerID=MN8TOARS.
    10.1016/S1470-2045(20)30219-9
  7. Corso, G.; Figueiredo, J.; De Angelis, S.P.; Corso, F.; Girardi, A.; Pereira, J.; Seruca, R.; et al. "E-cadherin deregulation in breast cancer". Journal of Cellular and Molecular Medicine 24 11 (2020): 5930-5936. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083449791&partnerID=MN8TOARS.
    10.1111/jcmm.15140
  8. Corso, G.; Montagna, G.; Figueiredo, J.; Vecchia, C.L.; Romario, U.F.; Fernandes, M.S.; Seixas, S.; et al. "Hereditary gastric and breast cancer syndromes related to CDH1 germline mutation: A multidisciplinary clinical review". Cancers 12 6 (2020): 1-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086649941&partnerID=MN8TOARS.
    10.3390/cancers12061598
  9. Leite, M.; Marques, M.S.; Melo, J.; Pinto, M.T.; Cavadas, B.; Aroso, M.; Gomez-Lazaro, M.; Seruca, R.; Figueiredo, C.. "Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions". Cells 9 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086741184&partnerID=MN8TOARS.
    10.3390/cells9020513
  10. Carvalho, P.D.; Machado, A.L.; Martins, F.; Seruca, R.; Velho, S.. "Targeting the tumor microenvironment: An unexplored strategy for mutant KRAS tumors". Cancers 11 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077305268&partnerID=MN8TOARS.
    10.3390/cancers11122010
  11. Carneiro, P.; Moreira, A.M.; Figueiredo, J.; Barros, R.; Oliveira, P.; Fernandes, M.S.; Ferro, A.; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Cell Communication and Signaling 17 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075548008&partnerID=MN8TOARS.
    10.1186/s12964-019-0465-9
  12. Figueiredo, J.; Melo, S.; Carneiro, P.; Moreira, A.M.; Fernandes, M.S.; Ribeiro, A.S.; Guilford, P.; Paredes, J.; Seruca, R.. "Clinical spectrum and pleiotropic nature of CDH1 germline mutations". Journal of Medical Genetics 56 4 (2019): 199-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060236556&partnerID=MN8TOARS.
    10.1136/jmedgenet-2018-105807
  13. Pena-Couso, L.; Perea, J.; Melo, S.; Mercadillo, F.; Figueiredo, J.; Sanches, J.M.; Sánchez-Ruiz, A.; et al. "Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer". European Journal of Human Genetics 26 9 (2018): 1348-1353. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046998829&partnerID=MN8TOARS.
    10.1038/s41431-018-0173-8
  14. Ribeiro, A.S.; Nobre, A.R.; Mendes, N.; Almeida, J.; Vieira, A.F.; Sousa, B.; Carvalho, F.A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell communication and signaling : CCS 16 1 (2018): 75-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056432555&partnerID=MN8TOARS.
    10.1186/s12964-018-0286-2
  15. Figueiredo, J.; Melo, S.; Gamet, K.; Godwin, T.; Seixas, S.; Sanches, J.M.; Guilford, P.; Seruca, R.. "E-cadherin signal sequence disruption: A novel mechanism underlying hereditary cancer". Molecular Cancer 17 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85051027654&partnerID=MN8TOARS.
    10.1186/s12943-018-0859-0
  16. Figueiredo, J.; Rodrigues, I.; Ribeiro, J.; Fernandes, M.S.; Melo, S.; Sousa, B.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Geometric compensation applied to image analysis of cell populations with morphological variability: A new role for a classical concept". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049644419&partnerID=MN8TOARS.
    10.1038/s41598-018-28570-z
  17. Corso, G.; Figueiredo, J.; La Vecchia, C.; Veronesi, P.; Pravettoni, G.; Macis, D.; Karam, R.; et al. "Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect". Journal of Medical Genetics 55 7 (2018): 431-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049325623&partnerID=MN8TOARS.
    10.1136/jmedgenet-2018-105337
  18. Zollinger, A.J.; Xu, H.; Figueiredo, J.; Paredes, J.; Seruca, R.; Stamenovic, D.; Smith, M.L.. "Dependence of Tensional Homeostasis on Cell Type and on Cell–Cell Interactions". Cellular and Molecular Bioengineering 11 3 (2018): 175-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046688489&partnerID=MN8TOARS.
    10.1007/s12195-018-0527-x
  19. Melo, S.; Figueiredo, J.; Fernandes, M.S.; Gonçalves, M.; Morais-De-Sá, E.; Sanches, J.M.; Seruca, R.. "Predicting the functional impact of CDH1 missense mutations in hereditary diffuse gastric cancer". International Journal of Molecular Sciences 18 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85038807279&partnerID=MN8TOARS.
    10.3390/ijms18122687
  20. Ferro, A.; Mestre, T.; Carneiro, P.; Sahumbaiev, I.; Seruca, R.; Sanches, J.M.. "Blue intensity matters for cell cycle profiling in fluorescence DAPI-stained images". Laboratory Investigation 97 5 (2017): 615-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019626964&partnerID=MN8TOARS.
    10.1038/labinvest.2017.13
  21. Carvalho, S.; Catarino, T.A.; Dias, A.M.; Kato, M.; Almeida, A.; Hessling, B.; Figueiredo, J.; et al. "Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer". Oncogene 35 13 (2016): 1619-1631. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937605601&partnerID=MN8TOARS.
    10.1038/onc.2015.225
  22. Mestre, T.; Figueiredo, J.; Ribeiro, A.S.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Quantification of topological features in cell meshes to explore E-cadherin dysfunction". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84971367761&partnerID=MN8TOARS.
    10.1038/srep25101
  23. Pinto, A.T.; Pinto, M.L.; Velho, S.; Pinto, M.T.; Cardoso, A.P.; Figueira, R.; Monteiro, A.; et al. "Intricate macrophage-colorectal cancer cell communication in response to radiation". PLoS ONE 11 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84983567727&partnerID=MN8TOARS.
    10.1371/journal.pone.0160891
  24. Carvalho, S.; Oliveira, T.; Bartels, M.F.; Miyoshi, E.; Pierce, M.; Taniguchi, N.; Carneiro, F.; et al. "O-mannosylation and N-glycosylation: Two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer". Oncotarget 7 40 (2016): 65231-65246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993660248&partnerID=MN8TOARS.
    10.18632/oncotarget.11245
  25. Teresa Pinto, A.; Laranjeiro Pinto, M.; Patrícia Cardoso, A.; Monteiro, C.; Teixeira Pinto, M.; Filipe Maia, A.; Castro, P.; et al. "Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954288518&partnerID=MN8TOARS.
    10.1038/srep18765
  26. Ribeiro, A.S.; Carvalho, F.A.; Figueiredo, J.; Carvalho, R.; Mestre, T.; Monteiro, J.; Guedes, A.F.; et al. "Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells". Nanoscale 8 46 (2016): 19390-19401. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998881935&partnerID=MN8TOARS.
    10.1039/c6nr04465d
  27. Branco da Cunha, C.; Klumpers, D.D.; Koshy, S.T.; Weaver, J.C.; Chaudhuri, O.; Seruca, R.; Carneiro, F.; Granja, P.L.; Mooney, D.J.. "CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness". Biomaterials 98 (2016): 152-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966708392&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.04.016
  28. Fernandes, M.S.; Melo, S.; Velho, S.; Carneiro, P.; Carneiro, F.; Seruca, R.. "Specific inhibition of p110a subunit of PI3K: Putative therapeutic strategy for KRAS mutant colorectal cancers". Oncotarget 7 42 (2016): 68546-68558. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014747304&partnerID=MN8TOARS.
  29. Zhang, L.; Xiao, A.; Ruggeri, J.; Bacares, R.; Somar, J.; Iqbal, S.; Ricker, C.; et al. "Corrigendum to "The germline CDH1 c.48 G > C substitution contributes to cancer predisposition through generation of a pro-invasive mutation" [Mutat. Res. 770, (2014), 106-111]". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 774 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927547974&partnerID=MN8TOARS.
    10.1016/j.mrfmmm.2015.04.001
  30. Brito, L.A.; Yamamoto, G.L.; Melo, S.; Malcher, C.; Ferreira, S.G.; Figueiredo, J.; Alvizi, L.; et al. "Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate". Human Mutation 36 11 (2015): 1029-1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944156790&partnerID=MN8TOARS.
    10.1002/humu.22827
  31. van der Post, R.S.; Vogelaar, I.P.; Carneiro, F.; Guilford, P.; Huntsman, D.; Hoogerbrugge, N.; Caldas, C.; et al. "Hereditary diffuse gastric cancer: Updated clinical guidelines with an emphasis on germline CDH1 mutation carriers". Journal of Medical Genetics 52 6 (2015): 361-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930650698&partnerID=MN8TOARS.
    10.1136/jmedgenet-2015-103094
  32. Vedeld, H.M.; Andresen, K.; Eilertsen, I.A.; Nesbakken, A.; Seruca, R.; Gladhaug, I.P.; Thiis-Evensen, E.; et al. "The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers". International Journal of Cancer 136 4 (2015): 844-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918780619&partnerID=MN8TOARS.
    10.1002/ijc.29039
  33. Sanches, J.M.; Figueiredo, J.; Fonseca, M.; Durães, C.; Melo, S.; Esménio, S.; Seruca, R.. "Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants". European Journal of Human Genetics 23 8 (2015): 1072-1079. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937515858&partnerID=MN8TOARS.
    10.1038/ejhg.2014.240
  34. Alves, S.; Castro, L.; Fernandes, M.S.; Francisco, R.; Castro, P.; Priault, M.; Chaves, S.R.; et al. "Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy". Oncotarget 6 31 (2015): 30787-30802. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945530861&partnerID=MN8TOARS.
    10.18632/oncotarget.5021
  35. Pinheiro, M.; Pinto, C.; Peixoto, A.; Veiga, I.; Lopes, P.; Henrique, R.; Baldaia, H.; et al. "Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation". British Journal of Cancer 113 4 (2015): 686-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939264921&partnerID=MN8TOARS.
    10.1038/bjc.2015.281
  36. Cardoso, A.P.; Pinto, M.L.; Pinto, A.T.; Pinto, M.T.; Monteiro, C.; Oliveira, M.I.; Santos, S.G.; et al. "Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour". BMC Cancer 15 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930669986&partnerID=MN8TOARS.
    10.1186/s12885-015-1466-8
  37. Oliveira, C.; Pinheiro, H.; Figueiredo, J.; Seruca, R.; Carneiro, F.. "Familial gastric cancer: Genetic susceptibility, pathology, and implications for management". The Lancet Oncology 16 2 (2015): e60-e70. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921774175&partnerID=MN8TOARS.
    10.1016/S1470-2045(14)71016-2
  38. Caldeira, J.; Figueiredo, J.; Brás-Pereira, C.; Carneiro, P.; Moreira, A.M.; Pinto, M.T.; Relvas, J.B.; et al. "E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade". Human Molecular Genetics 24 20 (2015): 5891-5900. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943762566&partnerID=MN8TOARS.
    10.1093/hmg/ddv312
  39. Corso, G.; Figueiredo, J.; Biffi, R.; Trentin, C.; Bonanni, B.; Feroce, I.; Serrano, D.; et al. "E-cadherin germline mutation carriers: clinical management and genetic implications". Cancer and Metastasis Reviews 33 4 (2014): 1081-1094. http://www.scopus.com/inward/record.url?eid=2-s2.0-84914121710&partnerID=MN8TOARS.
    10.1007/s10555-014-9528-y
  40. Carneiro, F.; Wen, X.; Seruca, R.; Oliveira, C.. "Familial gastric carcinoma". Diagnostic Histopathology 20 6 (2014): 239-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901696919&partnerID=MN8TOARS.
    10.1016/j.mpdhp.2014.03.010
  41. Bernardes, N.; Ribeiro, A.S.; Abreu, S.; Vieira, A.F.; Carreto, L.; Santos, M.; Seruca, R.; Paredes, J.; Fialho, A.M.. "High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin". International Journal of Biochemistry and Cell Biology 50 1 (2014): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896720191&partnerID=MN8TOARS.
    10.1016/j.biocel.2014.01.023
  42. Durães, C.; Almeida, G.M.; Seruca, R.; Oliveira, C.; Carneiro, F.. "Biomarkers for gastric cancer: Prognostic, predictive or targets of therapy?". Virchows Archiv 464 3 (2014): 367-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897048556&partnerID=MN8TOARS.
    10.1007/s00428-013-1533-y
  43. Velho, S.; Pinto, A.; Licastro, D.; Oliveira, M.J.; Sousa, F.; Stupka, E.; Seruca, R.. "Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation". BMC Cancer 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899084890&partnerID=MN8TOARS.
    10.1186/1471-2407-14-182
  44. Correia, M.; Casal, S.; Vinagre, J.; Seruca, R.; Figueiredo, C.; Touati, E.; Machado, J.C.. "Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid". International Journal of Medical Microbiology 304 3-4 (2014): 314-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899641976&partnerID=MN8TOARS.
    10.1016/j.ijmm.2013.11.018
  45. Pinheiro, H.; Oliveira, C.; Seruca, R.; Carneiro, F.. "Hereditary diffuse gastric cancer - Pathophysiology and clinical management". Best Practice and Research: Clinical Gastroenterology 28 6 (2014): 1055-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927921165&partnerID=MN8TOARS.
    10.1016/j.bpg.2014.09.007
  46. Simões-correia, J.; Silva, D.I.; Melo, S.; Figueiredo, J.; Caldeira, J.; Pinto, M.T.; Girão, H.; Pereira, P.; Seruca, R.. "DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo". Human Molecular Genetics 23 8 (2014): 2094-2105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897831766&partnerID=MN8TOARS.
    10.1093/hmg/ddt602
  47. Velho, S.; Fernandes, M.S.; Leite, M.; Figueiredo, C.; Seruca, R.. "Causes and consequences of microsatellite instability in gastric carcinogenesis". World Journal of Gastroenterology 20 44 (2014): 16433-16442. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918813931&partnerID=MN8TOARS.
    10.3748/wjg.v20.i44.16433
  48. Zhang, L.; Xiao, A.; Ruggeri, J.; Bacares, R.; Somar, J.; Melo, S.; Figueiredo, J.; et al. "The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 770 (2014): 106-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912111792&partnerID=MN8TOARS.
    10.1016/j.mrfmmm.2014.10.001
  49. Ferreira, A.M.; Tuominen, I.; Sousa, S.; Gerbens, F.; van Dijk-Bos, K.; Osinga, J.; Kooi, K.A.; et al. "New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers". Human Mutation 35 12 (2014): 1514-1523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911424739&partnerID=MN8TOARS.
    10.1002/humu.22700
  50. Correia, M.; Michel, V.; Osório, H.; El Ghachi, M.; Bonis, M.; Boneca, I.G.; de Reuse, H.; et al. "Crosstalk between Helicobacter pylori and Gastric Epithelial Cells Is Impaired by Docosahexaenoic Acid". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875962309&partnerID=MN8TOARS.
    10.1371/journal.pone.0060657
  51. Garziera, M.; De Re, V.; Geremia, S.; Seruca, R.; Figueiredo, J.; Melo, S.; Simões-Correia, J.; et al. "A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy". Clinical and Experimental Medicine 13 2 (2013): 149-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877788844&partnerID=MN8TOARS.
    10.1007/s10238-012-0184-7
  52. Oliveira, C.; Pinheiro, H.; Figueiredo, J.; Seruca, R.; Carneiro, F.. "E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer". Progress in Molecular Biology and Translational Science 116 (2013): 337-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875262175&partnerID=MN8TOARS.
    10.1016/B978-0-12-394311-8.00015-7
  53. Ribeiro, A.S.; Sousa, B.; Carreto, L.; Mendes, N.; Nobre, A.R.; Ricardo, S.; Albergaria, A.; et al. "P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model". Journal of Pathology 229 5 (2013): 705-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875054847&partnerID=MN8TOARS.
    10.1002/path.4143
  54. Oliveira, C.; Seruca, R.; Hoogerbrugge, N.; Ligtenberg, M.; Carneiro, F.. "Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC)". European Journal of Human Genetics 21 8 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880922499&partnerID=MN8TOARS.
    10.1038/ejhg.2012.247
  55. Esménio, S.; Figueiredo, J.; Seruca, R.; Sanches, J.M.. "E-cadherin radial distribution characterization for mutation detection purposes". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7887 LNCS (2013): 173-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883155798&partnerID=MN8TOARS.
    10.1007/978-3-642-38628-2_20
  56. Cardoso, A.P.; Pinto, M.L.; Pinto, A.T.; Oliveira, M.I.; Pinto, M.T.; Gonçalves, R.; Relvas, J.B.; et al. "Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity". Oncogene (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876908646&partnerID=MN8TOARS.
    10.1038/onc.2013.154
  57. Bernardes, N.; Ribeiro, A.S.; Abreu, S.; Mota, B.; Matos, R.G.; Arraiano, C.M.; Seruca, R.; Paredes, J.; Fialho, A.M.. "The Bacterial Protein Azurin Impairs Invasion and FAK/Src Signaling in P-Cadherin-Overexpressing Breast Cancer Cell Models". PLoS ONE 8 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880423678&partnerID=MN8TOARS.
    10.1371/journal.pone.0069023
  58. Albergaria, A.; Resende, C.; Nobre, A.R.; Ribeiro, A.S.; Sousa, B.; Machado, J.C.; Seruca, R.; Paredes, J.; Schmitt, F.. "CCAAT/Enhancer Binding Protein ß (C/EBPß) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873547668&partnerID=MN8TOARS.
    10.1371/journal.pone.0055749
  59. van der Werf, C.S.; Hsiao, N.-H.; Conroy, S.; Paredes, J.; Ribeiro, A.S.; Sribudiani, Y.; Seruca, R.; et al. "CLMP Is Essential for Intestinal Development, but Does Not Play a Key Role in Cellular Processes Involved in Intestinal Epithelial Development". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874534682&partnerID=MN8TOARS.
    10.1371/journal.pone.0054649
  60. Fernandes, M.S.; Carneiro, F.; Oliveira, C.; Seruca, R.. "Colorectal cancer and RASSF family-A special emphasis on RASSF1A". International Journal of Cancer 132 2 (2013): 251-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869503619&partnerID=MN8TOARS.
    10.1002/ijc.27696
  61. Costa, A.M.; Leite, M.; Seruca, R.; Figueiredo, C.. "Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori". FEBS Letters 587 3 (2013): 259-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872942923&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.12.008
  62. Vogelaar, I.P.; Figueiredo, J.; Van rooij, I.A.L.M.; Simões-correia, J.; Van der post, R.S.; Melo, S.; Seruca, R.; et al. "Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts". Human Molecular Genetics 22 5 (2013): 919-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873422090&partnerID=MN8TOARS.
    10.1093/hmg/dds497
  63. Figueiredo, J.; Söderberg, O.; Simões-Correia, J.; Grannas, K.; Suriano, G.; Seruca, R.. "The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC". European Journal of Human Genetics 21 3 (2013): 301-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874105136&partnerID=MN8TOARS.
    10.1038/ejhg.2012.159
  64. Pinho, S.S.; Figueiredo, J.; Cabral, J.; Carvalho, S.; Dourado, J.; Magalhães, A.; Gärtner, F.; et al. "E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and v". Biochimica et Biophysica Acta - General Subjects 1830 3 (2013): 2690-2700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873589547&partnerID=MN8TOARS.
    10.1016/j.bbagen.2012.10.021
  65. Corso, G.; Carvalho, J.; Marrelli, D.; Vindigni, C.; Carvalho, B.; Seruca, R.; Roviello, F.; Oliveira, C.. "Somatic mutations and deletions of the e-cadherin gene predict poor survival of patients with gastric cancer". Journal of Clinical Oncology 31 7 (2013): 868-875. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875753760&partnerID=MN8TOARS.
    10.1200/JCO.2012.44.4612
  66. Pinho, S.S.; Carvalho, S.; Marcos-Pinto, R.; Magalhães, A.; Oliveira, C.; Gu, J.; Dinis-Ribeiro, M.; et al. "Gastric cancer: Adding glycosylation to the equation". Trends in Molecular Medicine 19 11 (2013): 664-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886951831&partnerID=MN8TOARS.
    10.1016/j.molmed.2013.07.003
  67. Machado, A.M.D.; Desler, C.; Bøggild, S.; Strickertsson, J.A.B.; Friis-Hansen, L.; Figueiredo, C.; Seruca, R.; Rasmussen, L.J.. "Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells". Mechanisms of Ageing and Development (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883885587&partnerID=MN8TOARS.
    10.1016/j.mad.2013.08.004
  68. Carneiro, P.; Figueiredo, J.; Bordeira-Carriço, R.; Fernandes, M.S.; Carvalho, J.; Oliveira, C.; Seruca, R.. "Therapeutic targets associated to E-cadherin dysfunction in gastric cancer". Expert Opinion on Therapeutic Targets 17 10 (2013): 1187-1201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884582960&partnerID=MN8TOARS.
    10.1517/14728222.2013.827174
  69. De-Freitas-Junior, J.C.M.; Carvalho, S.; Dias, A.M.; Oliveira, P.; Cabral, J.; Seruca, R.; Oliveira, C.; et al. "Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. An interplay with E-cadherin". PLoS ONE 8 11 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896731020&partnerID=MN8TOARS.
    10.1371/journal.pone.0081579
  70. Carneiro, P.; Fernandes, M.S.; Figueiredo, J.; Caldeira, J.; Carvalho, J.; Pinheiro, H.; Leite, M.; et al. "E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions". FEBS Letters 586 18 (2012): 2981-2989. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922992&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.07.045
  71. Carvalho, J.; Van Grieken, N.C.; Pereira, P.M.; Sousa, S.; Tijssen, M.; Buffart, T.E.; Diosdado, B.; et al. "Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer". Journal of Pathology 228 1 (2012): 31-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864749110&partnerID=MN8TOARS.
    10.1002/path.4032
  72. Vieira, A.F.; Ricardo, S.; Ablett, M.P.; Dionísio, M.R.; Mendes, N.; Albergaria, A.; Farnie, G.; et al. "P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer". Stem Cells 30 5 (2012): 854-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860499799&partnerID=MN8TOARS.
    10.1002/stem.1075
  73. Caldeira, J.; Simões-Correia, J.; Paredes, J.; Pinto, M.T.; Sousa, S.; Corso, G.; Marrelli, D.; et al. "CPEB1, a novel gene silenced in gastric cancer: A Drosophila approach". Gut 61 8 (2012): 1115-1123. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863719147&partnerID=MN8TOARS.
    10.1136/gutjnl-2011-300427
  74. Lutz, M.P.; Zalcberg, J.R.; Ducreux, M.; Ajani, J.A.; Allum, W.; Aust, D.; Bang, Y.-J.; et al. "Highlights of the EORTC st. gallen international expert consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - Differential treatment strategies for subtypes of early gastroesophageal cancer". European Journal of Cancer 48 16 (2012): 2941-2953. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867571802&partnerID=MN8TOARS.
    10.1016/j.ejca.2012.07.029
  75. Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta - Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.
    10.1016/j.bbcan.2012.05.002
  76. Corso, G.; Seruca, R.; Roviello, F.. "Gastric cancer carcinogenesis and tumor progression". Annali Italiani di Chirurgia 83 3 (2012): 172-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866144479&partnerID=MN8TOARS.
  77. Pinheiro, H.; Carvalho, J.; Oliveira, P.; Ferreira, D.; Pinto, M.T.; Osoquot;rio, H.; Licastro, D.; et al. "Transcription initiation arising from E-cadherin/CDH1 intron2: A novel protein isoform that increases gastric cancer cell invasion and angiogenesis". Human Molecular Genetics 21 19 (2012): 4253-4269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866408689&partnerID=MN8TOARS.
    10.1093/hmg/dds248
  78. Sheu, J.J.-C.; Guan, B.; Tsai, F.-J.; Hsiao, E.Y.-T.; Chen, C.-M.; Seruca, R.; Wang, T.-L.; Shih, I.-M.. "Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells". American Journal of Pathology 180 3 (2012): 1179-1188. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863152979&partnerID=MN8TOARS.
    10.1016/j.ajpath.2011.11.026
  79. Van Der Werf, C.S.; Wabbersen, T.D.; Hsiao, N.; Paredes, J.; Etchevers, H.C.; Kroisel, P.M.; Tibboel, D.; et al. "CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome". Gastroenterology 142 3 (2012): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857636412&partnerID=MN8TOARS.
    10.1053/j.gastro.2011.11.038
  80. Ferreira, A.C.; Suriano, G.; Mendes, N.; Gomes, B.; Wen, X.; Carneiro, F.; Seruca, R.; Machado, J.C.. "E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2". Human Molecular Genetics 21 2 (2012): 334-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855365633&partnerID=MN8TOARS.
    10.1093/hmg/ddr469
  81. Alhopuro, P.; Sammalkorpi, H.; Niittymäki, I.; Biström, M.; Raitila, A.; Saharinen, J.; Nousiainen, K.; et al. "Candidate driver genes in microsatellite-unstable colorectal cancer". International Journal of Cancer 130 7 (2012): 1558-1566. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856331383&partnerID=MN8TOARS.
    10.1002/ijc.26167
  82. Correia, M.; Michel, V.; Matos, A.A.; Carvalho, P.; Oliveira, M.J.; Ferreira, R.M.; Dillies, M.-A.; et al. "Docosahexaenoic acid inhibits helicobacter pylori growth in vitro and mice gastric mucosa colonization". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859827322&partnerID=MN8TOARS.
    10.1371/journal.pone.0035072
  83. Pinho, S.S.; Oliveira, P.; Cabral, J.; Carvalho, S.; Huntsman, D.; Gärtner, F.; Seruca, R.; Reis, C.A.; Oliveira, C.. "Loss and recovery of Mgat3 and GnT-III mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-Mesenchymal-Epithelial transitions". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858138360&partnerID=MN8TOARS.
    10.1371/journal.pone.0033191
  84. Simões-Correia, J.; Figueiredo, J.; Lopes, R.; Stricher, F.; Oliveira, C.; Serrano, L.; Seruca, R.. "E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858685771&partnerID=MN8TOARS.
    10.1371/journal.pone.0033783
  85. Albergaria, A.; Ribeiro, A.-S.; Vieira, A.-F.; Sousa, B.; Nobre, A.-R.; Seruca, R.; Schmitt, F.; Paredes, J.. "P-cadherin role in normal breast development and cancer". International Journal of Developmental Biology 55 7-9 (2011): 811-822. http://www.scopus.com/inward/record.url?eid=2-s2.0-82555201366&partnerID=MN8TOARS.
    10.1387/ijdb.113382aa
  86. Corso, G.; Velho, S.; Paredes, J.; Pedrazzani, C.; Martins, D.; Milanezi, F.; Pascale, V.; et al. "Oncogenic mutations in gastric cancer with microsatellite instability". European Journal of Cancer 47 3 (2011): 443-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251593630&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.09.008
  87. Pinho, S.S.; Seruca, R.; Gärtner, F.; Yamaguchi, Y.; Gu, J.; Taniguchi, N.; Reis, C.A.. "Modulation of E-cadherin function and dysfunction by N-glycosylation". Cellular and Molecular Life Sciences 68 6 (2011): 1011-1020. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953721653&partnerID=MN8TOARS.
    10.1007/s00018-010-0595-0
  88. Figueiredo, J.; Simões-Correia, J.; Söderberg, O.; Suriano, G.; Seruca, R.. "ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80051508756&partnerID=MN8TOARS.
    10.1371/journal.pone.0023188
  89. Bernardes, N.; Ribeiro, A.S.; Seruca, R.; Paredes, J.; Fialho, A.M.. "Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053958083&partnerID=MN8TOARS.
    10.1109/ENBENG.2011.6026047
  90. Corso, G.; Pedrazzani, C.; Pinheiro, H.; Fernandes, E.; Marrelli, D.; Rinnovati, A.; Pascale, V.; et al. "E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer". European Journal of Cancer 47 4 (2011): 631-639. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851510776&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.10.011
  91. Leite, M.; Corso, G.; Sousa, S.; Milanezi, F.; Afonso, L.P.; Henrique, R.; Soares, J.M.; et al. "MSI phenotype and MMR alterations in familial and sporadic gastric cancer". International Journal of Cancer 128 7 (2011): 1606-1613. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551478326&partnerID=MN8TOARS.
    10.1002/ijc.25495
  92. Velho, S.; Corso, G.; Oliveíra, C.; Seruca, R.. "KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal Cancers". Advances in Cancer Research 109 C (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78149389848&partnerID=MN8TOARS.
    10.1016/B978-0-12-380890-5.00004-1
  93. Velho, S.; Corso, G.; Oliveíra, C.; Seruca, R.. "KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.". Advances in cancer research 109 (2010): 123-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952278820&partnerID=MN8TOARS.
  94. Bernardes, N.; Seruca, R.; Chakrabarty, A.M.; Fialho, A.M.. "Microbial-based therapy of Cancer Current progress and future prospects". Bioengineered Bugs 1 3 (2010): 178-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851473784&partnerID=MN8TOARS.
    10.4161/bbug.1.3.10903
  95. Carneiro, F.; Oliveira, C.; Seruca, R.. "Pathology and genetics of familial gastric cancer.". International journal of surgical pathology 18 3 Suppl (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77955856687&partnerID=MN8TOARS.
  96. Pinheiro, H.; Bordeira-Carriço, R.; Seixas, S.; Carvalho, J.; Senz, J.; Oliveira, P.; Inácio, P.; et al. "Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer". Human Molecular Genetics 19 5 (2010): 943-952. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950533734&partnerID=MN8TOARS.
    10.1093/hmg/ddp537
  97. Albergaria, A.; Ribeiro, A.S.; Pinho, S.; Milanezi, F.; Carneiro, V.; Sousa, B.; Sousa, S.; et al. "ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: A role for C/EBPß in CDH3 gene activation". Human Molecular Genetics 19 13 (2010): 2554-2566. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954172745&partnerID=MN8TOARS.
    10.1093/hmg/ddq134
  98. Da Cunha, C.B.; Oliveira, C.; Wen, X.; Gomes, B.; Sousa, S.; Suriano, G.; Grellier, M.; et al. "De novo expression of CD44 variants in sporadic and hereditary gastric cancer". Laboratory Investigation 90 11 (2010): 1604-1614. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049336816&partnerID=MN8TOARS.
    10.1038/labinvest.2010.155
  99. Svrcek, M.; Buhard, O.; Colas, C.; Coulet, F.; Dumont, S.; Massaoudi, I.; Lamri, A.; et al. "Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: An initiating step in the development of mismatch repair-deficient colorectal cancers". Gut 59 11 (2010): 1516-1526. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049517419&partnerID=MN8TOARS.
    10.1136/gut.2009.194787
  100. Machado, A.M.D.; Figueiredo, C.; Seruca, R.; Rasmussen, L.J.. "Helicobacter pylori infection generates genetic instability in gastric cells". Biochimica et Biophysica Acta - Reviews on Cancer 1806 1 (2010): 58-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953718630&partnerID=MN8TOARS.
    10.1016/j.bbcan.2010.01.007
  101. Regalo, G.; Resende, C.; Wen, X.; Gomes, B.; Dures, C.; Seruca, R.; Carneiro, F.; MacHado, J.C.. "C/EBPa expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis". Laboratory Investigation 90 8 (2010): 1132-1139. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955147186&partnerID=MN8TOARS.
    10.1038/labinvest.2010.79
  102. Ribeiro, A.S.; Albergaria, A.; Sousa, B.; Correia, A.L.; Bracke, M.; Seruca, R.; Schmitt, F.C.; Paredes, J.. "Extracellular cleavage and shedding of P-cadherin: A mechanism underlying the invasive behaviour of breast cancer cells". Oncogene 29 3 (2010): 392-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149183984&partnerID=MN8TOARS.
    10.1038/onc.2009.338
  103. Velho, S.; Oliveira, C.; Seruca, R.. "KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases". Journal of Clinical Oncology 27 1 (2009): 158-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149327464&partnerID=MN8TOARS.
    10.1200/JCO.2008.20.1525
  104. Oliveira, C.; Senz, J.; Kaurah, P.; Pinheiro, H.; Sanges, R.; Haegert, A.; Corso, G.; et al. "Germline CDH1 deletions in hereditary diffuse gastric cancer families". Human Molecular Genetics 18 9 (2009): 1545-1555. http://www.scopus.com/inward/record.url?eid=2-s2.0-64549109715&partnerID=MN8TOARS.
    10.1093/hmg/ddp046
  105. Machado, A.M.D.; Figueiredo, C.; Touati, E.; Máximo, V.; Sousa, S.; Michel, V.; Carneiro, F.; et al. "Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells". Clinical Cancer Research 15 9 (2009): 2995-3002. http://www.scopus.com/inward/record.url?eid=2-s2.0-65649154690&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-08-2686
  106. Van Krieken, J.H.J.M.; Jung, A.; Kirchner, T.; Carneiro, F.; Seruca, R.; Bosman, F.T.; Quirke, P.; et al. "KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program (Virchows Archiv DOI: 10.1007/s00428-008-0665-y)". Virchows Archiv 454 2 (2009): 233-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-59849115730&partnerID=MN8TOARS.
    10.1007/s00428-008-0712-8
  107. Oliveira, C.; Seruca, R.; Carneiro, F.. "Hereditary gastric cancer". Best Practice and Research: Clinical Gastroenterology 23 2 (2009): 147-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-65349162141&partnerID=MN8TOARS.
    10.1016/j.bpg.2009.02.003
  108. Borie, C.; Colas, C.; Dartigues, P.; Lazure, T.; Rince, P.; Buhard, O.; Folliot, P.; et al. "The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms". International Journal of Cancer 125 10 (2009): 2360-2366. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349861911&partnerID=MN8TOARS.
    10.1002/ijc.24681
  109. Pinto, C.; Veiga, I.; Pinheiro, M.; Peixoto, A.; Pinto, A.; Lopes, J.M.; Reis, R.M.; et al. "TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset". Familial Cancer 8 4 (2009): 383-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449519172&partnerID=MN8TOARS.
    10.1007/s10689-009-9251-y
  110. Viana-Pereira, M.; Almeida, I.; Sousa, S.; Mahler-Araújo, B.; Seruca, R.; Pimentel, J.; Reis, R.M.. "Analysis of microsatellite instability in medulloblastoma". Neuro-Oncology 11 5 (2009): 458-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349622987&partnerID=MN8TOARS.
    10.1215/15228517-2008-115
  111. Preto, A.; Gonçalves, J.; Rebocho, A.P.; Figueiredo, J.; Meireles, A.M.; Rocha, A.S.; Vasconcelos, H.M.; et al. "Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations". BMC Cancer 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70749088911&partnerID=MN8TOARS.
    10.1186/1471-2407-9-387
  112. Velho, S.; Oliveira, C.; Paredes, J.; Sousa, S.; Leite, M.; Matos, P.; Milanezi, F.; et al. "Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours". Human Molecular Genetics 19 4 (2009): 697-706. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950353937&partnerID=MN8TOARS.
    10.1093/hmg/ddp536
  113. Corso, G.; Marrelli, D.; Pedrazzani, C.; Machado, J.C.; Mancini, S.; Seruca, R.; Roviello, F.. "Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-Ray Cross-Complementing Group 1 (XRCC1)". Journal of Gastrointestinal Surgery 13 12 (2009): 2233-2238. http://www.scopus.com/inward/record.url?eid=2-s2.0-71149103691&partnerID=MN8TOARS.
    10.1007/s11605-009-0980-x
  114. Ferreira, A.M.; Westers, H.; Albergaria, A.; Seruca, R.; Hofstra, R.M.W.. "Estrogens, MSI and Lynch syndrome-associated tumors". Biochimica et Biophysica Acta - Reviews on Cancer 1796 2 (2009): 194-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349181786&partnerID=MN8TOARS.
    10.1016/j.bbcan.2009.06.004
  115. Pinho, S.S.; Reis, C.A.; Paredes, J.; Magalhães, A.M.; Ferreira, A.C.; Figueiredo, J.; Xiaogang, W.; et al. "The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin". Human Molecular Genetics 18 14 (2009): 2599-2608. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649859659&partnerID=MN8TOARS.
    10.1093/hmg/ddp194
  116. Xavier, C.P.R.; Lima, C.F.; Preto, A.; Seruca, R.; Fernandes-Ferreira, M.; Pereira-Wilson, C.. "Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells". Cancer Letters 281 2 (2009): 162-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349181288&partnerID=MN8TOARS.
    10.1016/j.canlet.2009.02.041
  117. Mateus, A.R.; Simões-Correia, J.; Figueiredo, J.; Heindl, S.; Alves, C.C.; Suriano, G.; Luber, B.; Seruca, R.. "E-cadherin mutations and cell motility: A genotype-phenotype correlation". Experimental Cell Research 315 8 (2009): 1393-1402. http://www.scopus.com/inward/record.url?eid=2-s2.0-64049089800&partnerID=MN8TOARS.
    10.1016/j.yexcr.2009.02.020
  118. Oliveira, C.; Sousa, S.; Pinheiro, H.; Karam, R.; Bordeira-Carriço, R.; Senz, J.; Kaurah, P.; et al. "Quantification of Epigenetic and Genetic 2nd Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression". Gastroenterology 136 7 (2009): 2137-2148. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149108352&partnerID=MN8TOARS.
    10.1053/j.gastro.2009.02.065
  119. Ferreira, A.M.; Westers, H.; Sousa, S.; Wu, Y.; Niessen, R.C.; Olderode-Berends, M.; Van Der Sluis, T.; et al. "Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients". Journal of Pathology 219 1 (2009): 96-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-68849101943&partnerID=MN8TOARS.
    10.1002/path.2573
  120. Seruca, R.; Velho, S.; Oliveira, C.; Leite, M.; Matos, P.; Jordan, P.. "Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors". Expert Review of Gastroenterology and Hepatology 3 1 (2009): 5-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549085862&partnerID=MN8TOARS.
    10.1586/17474124.3.1.5
  121. Oliveira, M.J.; Costa, A.M.; Costa, A.C.; Ferreira, R.M.; Sampaio, P.; Machado, J.C.; Seruca, R.; Mareei, M.; Figueiredo, C.. "CagA associates with c-met, E-cadherin, and p120catenin in a multiproteic complex that suppresses helicobacter pylori-induced cell-invasive phenotype". Journal of Infectious Diseases 200 5 (2009): 745-755. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649120160&partnerID=MN8TOARS.
    10.1086/604727
  122. Pedrazzani, C.; Corso, G.; Velho, S.; Leite, M.; Pascale, V.; Bettarini, F.; Marrelli, D.; Seruca, R.; Roviello, F.. "Evidence of tumor microsatellite instability in gastric cancer with familial aggregation". Familial Cancer 8 3 (2009): 215-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-68449100164&partnerID=MN8TOARS.
    10.1007/s10689-008-9231-7
  123. Simões-Correia, J.; Figueiredo, J.; Oliveira, C.; van Hengel, J.; Seruca, R.; van Roy, F.; Suriano, G.. "Endoplasmic reticulum quality control: A new mechanism of E-cadherin regulation and its implication in cancer". Human Molecular Genetics 17 22 (2008): 3566-3576. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949124637&partnerID=MN8TOARS.
    10.1093/hmg/ddn249
  124. Van Krieken, J.H.J.M.; Jung, A.; Kirchner, T.; Carneiro, F.; Seruca, R.; Bosman, F.T.; Quirke, P.; et al. "KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: Proposal for an European quality assurance program". Virchows Archiv 453 5 (2008): 417-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249098184&partnerID=MN8TOARS.
    10.1007/s00428-008-0665-y
  125. Carneiro, F.; Oliveira, C.; Leite, M.; Seruca, R.. "Molecular targets and biological modifiers in gastric cancer". Seminars in Diagnostic Pathology 25 4 (2008): 274-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-53749100421&partnerID=MN8TOARS.
    10.1053/j.semdp.2008.07.004
  126. Preto, A.; Figueiredo, J.; Velho, S.; Ribeiro, A.S.; Soares, P.; Oliveira, C.; Seruca, R.. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAFV600E but not KRAS mutations". Journal of Pathology 214 3 (2008): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949208776&partnerID=MN8TOARS.
    10.1002/path.2295
  127. Karam, R.; Carvalho, J.; Bruno, I.; Graziadio, C.; Senz, J.; Huntsman, D.; Carneiro, F.; et al. "The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers". Oncogene 27 30 (2008): 4255-4260. http://www.scopus.com/inward/record.url?eid=2-s2.0-47049115051&partnerID=MN8TOARS.
    10.1038/onc.2008.62
  128. Moutinho, C.; Mateus, A.R.; Milanezi, F.; Carneiro, F.; Seruca, R.; Suriano, G.. "Epidermal growth factor receptor structural alterations in gastric cancer". BMC Cancer 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-39449083450&partnerID=MN8TOARS.
    10.1186/1471-2407-8-10
  129. Canedo, P.; Castanheira-Vale, A.J.; Lunet, N.; Pereira, F.; Figueiredo, C.; Gioia-Patricola, L.; Canzian, F.; et al. "The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population". European Journal of Cancer Prevention 17 1 (2008): 28-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-37449021640&partnerID=MN8TOARS.
    10.1097/CEJ.0b013e32809b4d0f
  130. Velho, S.; Moutinho, C.; Cirnes, L.; Albuquerque, C.; Hamelin, R.; Schmitt, F.; Carneiro, F.; Oliveira, C.; Seruca, R.. "BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?". BMC Cancer 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-53149097362&partnerID=MN8TOARS.
    10.1186/1471-2407-8-255
  131. Canedo, P.; Corso, G.; Pereira, F.; Lunet, N.; Suriano, G.; Figueiredo, C.; Pedrazzani, C.; et al. "The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma". Gut 57 11 (2008): 1504-1508. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349104757&partnerID=MN8TOARS.
    10.1136/gut.2007.143578
  132. Matos, P.; Oliveira, C.; Velho, S.; Gonçalves, V.; da Costa, L.T.; Moyer, M.P.; Seruca, R.; Jordan, P.. "B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival". Gastroenterology 135 3 (2008): 899-906. http://www.scopus.com/inward/record.url?eid=2-s2.0-51249098983&partnerID=MN8TOARS.
    10.1053/j.gastro.2008.05.052
  133. Canedo, P.; Durães, C.; Pereira, F.; Regalo, G.; Lunet, N.; Barros, H.; Carneiro, F.; et al. "Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma". Cancer Epidemiology Biomarkers and Prevention 17 9 (2008): 2416-2420. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349171324&partnerID=MN8TOARS.
    10.1158/1055-9965.EPI-08-0413
  134. Roviello, F.; Corso, G.; Pedrazzani, C.; Marrelli, D.; De Falco, G.; Suriano, G.; Vindigni, C.; et al. "High incidence of familial gastric cancer in Tuscany, a region in Italy". Oncology 72 3-4 (2008): 243-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549090648&partnerID=MN8TOARS.
    10.1159/000113015
  135. Pinto, M.; Wu, Y.; Mensink, R.G.J.; Cirnes, L.; Seruca, R.; Hofstra, R.M.W.. "Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype". Cancer Genetics and Cytogenetics 180 2 (2008): 110-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-38149120762&partnerID=MN8TOARS.
    10.1016/j.cancergencyto.2007.09.022
  136. Carneiro, F.; Oliveira, C.; Suriano, G.; Seruca, R.. "Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer". Journal of Clinical Pathology 61 1 (2008): 25-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449100410&partnerID=MN8TOARS.
    10.1136/jcp.2006.043679
  137. Suriano, G.; Azevedo, L.; Novais, M.; Boscolo, B.; Seruca, R.; Amorim, A.; Ghibaudi, E.M.. "In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model". Human Molecular Genetics 16 18 (2007): 2209-2214. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548450156&partnerID=MN8TOARS.
    10.1093/hmg/ddm172
  138. Svrcek, M.; El-Bchiri, J.; Chalastanis, A.; Capel, E.; Dumont, S.; Buhard, O.; Oliveira, C.; et al. "Specific clinical and biological features characterize inflammatory bowel disease-associated colorectal cancers showing microsatellite instability". Journal of Clinical Oncology 25 27 (2007): 4231-4238. http://www.scopus.com/inward/record.url?eid=2-s2.0-34948868310&partnerID=MN8TOARS.
    10.1200/JCO.2007.10.9744
  139. Preto, A.; Moutinho, C.; Velho, S.; Oliveira, C.; Rebocho, A.P.; Figueiredo, J.; Soares, P.; Lopes, J.M.; Seruca, R.. "A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation". Virchows Archiv 450 6 (2007): 619-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250805986&partnerID=MN8TOARS.
    10.1007/s00428-007-0420-9
  140. Mateus, A.R.; Seruca, R.; Machado, J.C.; Keller, G.; Oliveira, M.J.; Suriano, G.; Luber, B.. "EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells". Human Molecular Genetics 16 13 (2007): 1639-1647. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447317535&partnerID=MN8TOARS.
    10.1093/hmg/ddm113
  141. Corso, G.; Roviello, F.; Paredes, J.; Pedrazzani, C.; Novais, M.; Correia, J.; Marrelli, D.; et al. "Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management". European Journal of Surgical Oncology 33 9 (2007): 1061-1067. http://www.scopus.com/inward/record.url?eid=2-s2.0-35549011087&partnerID=MN8TOARS.
    10.1016/j.ejso.2007.03.001
  142. Alazzouzi, H.; Suriano, G.; Guerra, A.; Plaja, A.; Espín, E.; Armengol, M.; Alhopuro, P.; et al. "Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells". Journal of Medical Genetics 44 1 (2007): 75-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846443195&partnerID=MN8TOARS.
    10.1136/jmg.2006.042572
  143. Oliveira, C.; Velho, S.; Moutinho, C.; Ferreira, A.; Preto, A.; Domingo, E.; Capelinha, A.F.; et al. "KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression". Oncogene 26 1 (2007): 158-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846048042&partnerID=MN8TOARS.
    10.1038/sj.onc.1209758
  144. More, H.; Humar, B.; Weber, W.; Ward, R.; Christian, A.; Lintott, C.; Graziano, F.; et al. "Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene.". Human mutation 28 2 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-33847720755&partnerID=MN8TOARS.
  145. Roviello, F.; Corso, G.; Pedrazzani, C.; Marrelli, D.; De Falco, G.; Berardi, A.; Garosi, L.; et al. "Hereditary diffuse gastric cancer and E-cadherin: Description of the first germline mutation in an Italian family". European Journal of Surgical Oncology 33 4 (2007): 448-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247162631&partnerID=MN8TOARS.
    10.1016/j.ejso.2006.10.028
  146. Davalos, V.; Dopeso, H.; Velho, S.; Ferreira, A.M.; Cirnes, L.; Díaz-Chico, N.; Bilbao, C.; et al. "High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability". Oncogene 26 2 (2007): 308-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846239265&partnerID=MN8TOARS.
    10.1038/sj.onc.1209780
  147. Seixas, S.; Suriano, G.; Carvalho, F.; Seruca, R.; Rocha, J.; Di Rienzo, A.. "Sequence diversity at the proximal 14q32.1 SERPIN subcluster: Evidence for natural selection favoring the pseudogenization of SERPINA2". Molecular Biology and Evolution 24 2 (2007): 587-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846805804&partnerID=MN8TOARS.
    10.1093/molbev/msl187
  148. Oliveira, C.; Seruca, R.; Carneiro, F.. "Genetics, pathology, and clinics of familial gastric cancer". International Journal of Surgical Pathology 14 1 (2006): 21-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-32344433111&partnerID=MN8TOARS.
    10.1177/106689690601400105
  149. Frebourg, T.; Oliveira, C.; Hochain, P.; Karam, R.; Manouvrier, S.; Graziadio, C.; Vekemans, M.; et al. "Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer". Journal of Medical Genetics 43 2 (2006): 138-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-32944469779&partnerID=MN8TOARS.
    10.1136/jmg.2005.031385
  150. Castro, P.; Soares, P.; Gusmão, L.; Seruca, R.; Sobrinho-Simões, M.. "H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid". Oncogene 25 33 (2006): 4620-4627. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746789351&partnerID=MN8TOARS.
    10.1038/sj.onc.1209491
  151. Oliveira, M.J.; Costa, A.C.; Costa, A.M.; Henriques, L.; Suriano, G.; Atherton, J.C.; Machado, J.C.; et al. "Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner". Journal of Biological Chemistry 281 46 (2006): 34888-34896. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845953709&partnerID=MN8TOARS.
    10.1074/jbc.M607067200
  152. Pereira, P.S.; Teixeira, A.; Pinho, S.; Ferreira, P.; Fernandes, J.; Oliveira, C.; Seruca, R.; Suriano, G.; Casares, F.. "E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia". Human Molecular Genetics 15 10 (2006): 1704-1712. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745184835&partnerID=MN8TOARS.
    10.1093/hmg/ddl093
  153. Suriano, G.; Ferreira, P.; Mateus, A.R.; Correia, J.; Henriques, L.; Seruca, R.. "Genetics of hereditary diffuse gastric cancer: Progress and future challenges". Future Oncology 2 3 (2006): 363-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745501168&partnerID=MN8TOARS.
    10.2217/14796694.2.3.363
  154. Suriano, G.; Seixas, S.; Rocha, J.; Seruca, R.. "A model to infer the pathogenic significance of CDH1 germline missense variants". Journal of Molecular Medicine 84 12 (2006): 1023-1031. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249980933&partnerID=MN8TOARS.
    10.1007/s00109-006-0091-z
  155. Regalo, G.; Canedo, P.; Suriano, G.; Resende, C.; Campos, M.L.; Oliveira, M.J.; Figueiredo, C.; et al. "C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression". Journal of Pathology 210 4 (2006): 398-404. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751521001&partnerID=MN8TOARS.
    10.1002/path.2063
  156. Ferreira, P.; Oliveira, M.J.; Beraldi, E.; Mateus, A.R.; Nakajima, T.; Gleave, M.; Yokota, J.; et al. "Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro". Experimental Cell Research 310 1 (2005): 99-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844493033&partnerID=MN8TOARS.
    10.1016/j.yexcr.2005.07.010
  157. Oliveira, C.; Velho, S.; Domingo, E.; Preto, A.; Hofstra, R.M.W.; Hamelin, R.; Yamamoto, H.; Seruca, R.; Schwartz Jr., S.. "Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer". Oncogene 24 51 (2005): 7630-7634. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844458489&partnerID=MN8TOARS.
    10.1038/sj.onc.1208906
  158. Oliveira, C.; Moreira, H.; Seruca, R.; De Oliveira, M.C.; Carneiro, F.. "Role of pathology in the identification of hereditary diffuse gastric cancer: Report of a Portuguese family". Virchows Archiv 446 2 (2005): 181-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244362093&partnerID=MN8TOARS.
    10.1007/s00428-004-1156-4
  159. Suriano, G.; Vrcelj, N.; Senz, J.; Ferreira, P.; Masoudi, H.; Cox, K.; Nabais, S.; et al. "ß-catenin (CTNNB1) gene amplification: A new mechanism of protein overexpression in cancer". Genes Chromosomes and Cancer 42 3 (2005): 238-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944433965&partnerID=MN8TOARS.
    10.1002/gcc.20135
  160. Velho, S.; Oliveira, C.; Ferreira, A.; Ferreira, A.C.; Suriano, G.; Schwartz Jr., S.; Duval, A.; et al. "The prevalence of PIK3CA mutations in gastric and colon cancer". European Journal of Cancer 41 11 (2005): 1649-1654. http://www.scopus.com/inward/record.url?eid=2-s2.0-22144452507&partnerID=MN8TOARS.
    10.1016/j.ejca.2005.04.022
  161. Suriano, G.; Yew, S.; Ferreira, P.; Senz, J.; Kaurah, P.; Ford, J.M.; Longacre, T.A.; et al. "Characterization of a recurrent germ line mutation of the E-cadherin gene: Implications for genetic testing and clinical management". Clinical Cancer Research 11 15 (2005): 5401-5409. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044486914&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-05-0247
  162. Ferreira, A.C.; Almeida, S.; Tavares, M.; Canedo, P.; Pereira, F.; Regalo, G.; Figueiredo, C.; et al. "NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease". Inflammatory Bowel Diseases 11 4 (2005): 331-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-20244373335&partnerID=MN8TOARS.
    10.1097/01.MIB.0000158153.71579.b4
  163. Domingo, E.; Niessen, R.C.; Oliveira, C.; Alhopuro, P.; Moutinho, C.; Espin, E.; Armengol, M.; et al. "BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes". Oncogene 24 24 (2005): 3995-3998. http://www.scopus.com/inward/record.url?eid=2-s2.0-20544437157&partnerID=MN8TOARS.
    10.1038/sj.onc.1208569
  164. Oliveira, C.; Suriano, G.; Ferreira, P.; Canedo, P.; Kaurah, P.; Mateus, R.; Ferreira, A.; et al. "Genetic screening for familial gastric cancer". Hereditary Cancer in Clinical Practice 2 2 (2004): 51-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013124211&partnerID=MN8TOARS.
    10.1186/1897-4287-2-2-51
  165. Domingo, E.; Laiho, P.; Ollikainen, M.; Pinto, M.; Wang, L.; French, A.J.; Westra, J.; et al. "BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing". Journal of Medical Genetics 41 9 (2004): 664-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444311092&partnerID=MN8TOARS.
    10.1136/jmg.2004.020651
  166. Oliveira, C.; Westra, J.L.; Arango, D.; Ollikainen, M.; Domingo, E.; Ferreira, A.; Velho, S.; et al. "Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status". Human Molecular Genetics 13 19 (2004): 2303-2311. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444224121&partnerID=MN8TOARS.
    10.1093/hmg/ddh238
  167. Domingo, E.; Espín, E.; Armengol, M.; Oliveira, C.; Pinto, M.; Duval, A.; Brennetot, C.; et al. "Activated BRAF Targets Proximal Colon Tumors with Mismatch Repair Deficiency and MLH1 Inactivation". Genes Chromosomes and Cancer 39 2 (2004): 138-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-9144271690&partnerID=MN8TOARS.
    10.1002/gcc.10310
  168. Oliveira, C.; De Bruin, J.; Nabais, S.; Ligtenberg, M.; Moutinho, C.; Nagengast, F.M.; Seruca, R.; Van Krieken, H.; Carneiro, F.. "Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour". Oncogene 23 12 (2004): 2236-2240. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842591223&partnerID=MN8TOARS.
    10.1038/sj.onc.1207335
  169. Brooks-Wilson, A.R.; Kaurah, P.; Suriano, G.; Leach, S.; Senz, J.; Grehan, N.; Butterfield, Y.S.N.; et al. "Germline E-cadherin mutations in hereditary diffuse gastric cancer: Assessment of 42 new families and review of genetic screening criteria". Journal of Medical Genetics 41 7 (2004): 508-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142695439&partnerID=MN8TOARS.
  170. Oliveira, C.; Ferreira, P.; Nabais, S.; Campos, L.; Ferreira, A.; Cirnes, L.; Castro Alves, C.; et al. "E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients". European Journal of Cancer 40 12 (2004): 1897-1903. http://www.scopus.com/inward/record.url?eid=2-s2.0-3843061612&partnerID=MN8TOARS.
    10.1016/j.ejca.2004.04.027
  171. Keller, G.; Vogelsang, H.; Becker, I.; Plaschke, S.; Ott, K.; Suriano, G.; Mateus, A.R.; et al. "Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients.". Journal of medical genetics 41 6 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-19444376902&partnerID=MN8TOARS.
  172. Carneiro, F.; Huntsman, D.G.; Smyrk, T.C.; Owen, D.A.; Seruca, R.; Pharoah, P.; Caldas, C.; Sobrinho-Simões, M.. "Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening". Journal of Pathology 203 2 (2004): 681-687. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642556280&partnerID=MN8TOARS.
    10.1002/path.1564
  173. Mesquita, P.; Peixoto, A.J.; Seruca, R.; Hanski, C.; Almeida, R.; Silva, F.; Reis, C.; David, L.. "Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas". Cancer Letters 189 2 (2003): 129-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037469101&partnerID=MN8TOARS.
    10.1016/S0304-3835(02)00549-9
  174. Suriano, G.; Oliveira, C.; Ferreira, P.; Machado, J.C.; Bordin, M.C.; De Wever, O.; Bruyneel, E.A.; et al. "Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands". Human Molecular Genetics 12 5 (2003): 575-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037342636&partnerID=MN8TOARS.
    10.1093/hmg/ddg048
  175. Nabais, S.; Machado, J.C.; Lopes, C.; Seruca, R.; Carneiro, F.; Sobrinho-Simões, M.. "Patterns of ß-catenin expression in gastric carcinoma: Clinicopathological relevance and mutation analysis". International Journal of Surgical Pathology 11 1 (2003): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037283955&partnerID=MN8TOARS.
  176. Thorstensen, L.; Holm, R.; Lothe, R.A.; Tropé, C.; Carvalho, B.; Sobrinho-Simoes, M.; Seruca, R.. "WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas [2]". Gastroenterology 124 1 (2003): 270-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037223656&partnerID=MN8TOARS.
    10.1053/gast.2003.50034
  177. Suriano, G.; Oliveira, M.J.; Huntsman, D.; Mateus, A.R.; Ferreira, P.; Casares, F.; Oliveira, C.; et al. "E-cadherin germline missense mutations and cell phenotype: Evidence for the independence of cell invasion on the motile capabilities of the cells". Human Molecular Genetics 12 22 (2003): 3007-3016. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744230392&partnerID=MN8TOARS.
    10.1093/hmg/ddg316
  178. Oliveira, C.; Pinto, M.; Duval, A.; Brennetot, C.; Domingo, E.; Espín, E.; Armengol, M.; et al. "BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency". Oncogene 22 57 (2003): 9192-9196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346057796&partnerID=MN8TOARS.
    10.1038/sj.onc.1207061
  179. Carvalho, B.; Pinto, M.; Cirnes, L.; Oliveira, C.; Machado, J.C.; Suriano, G.; Hamelin, R.; Carneiro, F.; Seruca, R.. "Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas". European Journal of Cancer 39 9 (2003): 1222-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037565368&partnerID=MN8TOARS.
    10.1016/S0959-8049(03)00177-1
  180. Soares, P.; Trovisco, V.; Rocha, A.S.; Lima, J.; Castro, P.; Preto, A.; Máximo, V.; et al. "BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC". Oncogene 22 29 (2003): 4578-4580. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043170833&partnerID=MN8TOARS.
    10.1038/sj.onc.1206706
  181. Oliveira, C.; Seruca, R.; Caldas, C.. "Genetic screening for hereditary diffuse gastric cancer". Expert Review of Molecular Diagnostics 3 2 (2003): 201-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0012463365&partnerID=MN8TOARS.
    10.1586/14737159.3.2.201
  182. Pinto, M.; Oliveira, C.; Cirnes, L.; Machado, J.C.; Ramires, M.; Nogueira, A.; Carneiro, F.; Seruca, R.. "Promoter methylation of TGFß receptor I and mutation of TGFß receptor II are frequent events in MSI sporadic gastric carcinomas". Journal of Pathology 200 1 (2003): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037987704&partnerID=MN8TOARS.
    10.1002/path.1327
  183. Pinto, M.; Wu, Y.; Suriano, G.; Mensink, R.G.J.; Duval, A.; Oliveira, C.; Carvalho, B.; et al. "MBD4 mutations are rare in gastric carcinomas with microsatellite instability". Cancer Genetics and Cytogenetics 145 2 (2003): 103-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043165104&partnerID=MN8TOARS.
    10.1016/S0165-4608(03)00062-1
  184. Brennetot, C.; Duval, A.; Hamelin, R.; Pinto, M.; Oliveira, C.; Seruca, R.; Schwartz Jr., S.. "Frequent Ki-ras mutations in gastric tumors of the MSI phenotype [1]". Gastroenterology 125 4 (2003): 1282-1283. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141483004&partnerID=MN8TOARS.
    10.1016/j.gastro.2003.02.002
  185. Machado, J.C.; Figueiredo, C.; Canedo, P.; Pharoah, P.; Carvalho, R.; Nabais, S.; Castro Alves, C.; et al. "A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma". Gastroenterology 125 2 (2003): 364-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042667008&partnerID=MN8TOARS.
    10.1016/S0016-5085(03)00899-0
  186. Suriano, G.; Mulholland, D.; De Wever, O.; Ferreira, P.; Mateus, A.R.; Bruyneel, E.; Nelson, C.C.; et al. "The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion". Oncogene 22 36 (2003): 5716-5719. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042337360&partnerID=MN8TOARS.
    10.1038/sj.onc.1206672
  187. Figueiredo, C.; Machado, J.C.; Pharoah, P.; Seruca, R.; Sousa, S.; Carvalho, R.; Capelinha, A.F.; et al. "Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma". Journal of the National Cancer Institute 94 22 (2002): 1680-1687. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037146297&partnerID=MN8TOARS.
  188. Suraweera, N.; Duval, A.; Reperant, M.; Vaury, C.; Furlan, D.; Leroy, K.; Seruca, R.; Iacopetta, B.; Hamelin, R.. "Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR". Gastroenterology 123 6 (2002): 1804-1811. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036893598&partnerID=MN8TOARS.
    10.1053/gast.2002.37070
  189. Carvalho, R.; Kayademir, T.; Soares, P.; Canedo, P.; Sousa, S.; Oliveira, C.; Leistenschneider, P.; et al. "Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma". Laboratory Investigation 82 10 (2002): 1319-1326. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036800412&partnerID=MN8TOARS.
    10.1097/01.LAB.0000029205.76632.A8
  190. Nabais, S.; Machado, J.C.; Lopes, C.; Seruca, R.; Carneiro, F.; Sobrinho-Simões, M.. "Different patterns of ß-catenin expression in gastric carcinomas: Relationship with clinicopathological parameters and prognostic outcome [3]". Histopathology 41 4 (2002): 368-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036415121&partnerID=MN8TOARS.
    10.1046/j.1365-2559.2002.15253.x
  191. Oliveira, C.; Bordin, M.C.; Grehan, N.; Huntsman, D.; Suriano, G.; Machado, J.C.; Kiviluoto, T.; et al. "Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred". Human Mutation 19 5 (2002): 510-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-18344384564&partnerID=MN8TOARS.
    10.1002/humu.10068
  192. Carvalho, B.; Seruca, R.; Buys, C.H.C.M.; Kok, K.. "Novel expressed sequences obtained by means of a suppression subtractive hybridisation analysis from the 6q21 region that is frequently deleted in gastric cancer". European Journal of Cancer 38 8 (2002): 1126-1132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036252226&partnerID=MN8TOARS.
    10.1016/S0959-8049(02)00014-X
  193. Duval, A.; Reperant, M.; Compoint, A.; Seruca, R.; Ranzani, G.N.; Iacopetta, B.; Hamelin, R.. "Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency". Cancer Research 62 6 (2002): 1609-1612. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037086076&partnerID=MN8TOARS.
  194. Huntsman, D.G.; Carneiro, F.; Lewis, F.R.; MacLeod, P.M.; Hayashi, A.; Monaghan, K.G.; Maung, R.; et al. "Prophylactic gastrectomy in patients with deleterious E-cadherin gene mutation | Intérêt de la gastrectomie prophylactique chez les sujets porteurs d'une mutation délétère du gène de la e-cadhérine". Gastroenterologie Clinique et Biologique 25 10 (2001): 931-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035163112&partnerID=MN8TOARS.
  195. Nabais, S.; Carneiro, F.; Nogueira, A.M.M.F.; Machado, J.C.; Seruca, R.; Sobrinho-Simões, M.. "Re. 'Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways' (multiple letters)". Journal of Pathology 195 5 (2001): 636-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035663489&partnerID=MN8TOARS.
    10.1002/path.958
  196. Máximo, V.; Soares, P.; Seruca, R.; Rocha, A.S.; Castro, P.; Sobrinho-Simões, M.. "Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma". Genes Chromosomes and Cancer 32 2 (2001): 136-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034854114&partnerID=MN8TOARS.
    10.1002/gcc.1175
  197. Machado, J.C.; Pharoah, P.; Sousa, S.; Carvalho, R.; Oliveira, C.; Figueiredo, C.; Amorim, A.; et al. "Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma". Gastroenterology 121 4 (2001): 823-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034793044&partnerID=MN8TOARS.
    10.1053/gast.2001.28000
  198. Carvalho, B.; Y van der Veen, A.; Gärtner, F.; Carneiro, F.; Seruca, R.; Buys, C.H.C.M.; Kok, K.. "Allelic gains and losses in distinct regions of chromosome 6 in gastric carcinoma". Cancer Genetics and Cytogenetics 131 1 (2001): 54-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035187688&partnerID=MN8TOARS.
    10.1016/S0165-4608(01)00514-3
  199. Huntsman, D.G.; Carneiro, F.; Lewis, F.R.; Macleod, P.M.; Hayashi, A.; Monaghan, K.G.; Maung, R.; et al. "Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations". New England Journal of Medicine 344 25 (2001): 1904-1909. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035927967&partnerID=MN8TOARS.
    10.1056/NEJM200106213442504
  200. Rocha, A.S.; Soares, P.; Seruca, R.; Máximo, V.; Matias-Guiu, X.; Cameselle-Teijeiro, J.; Sobrinho-Simões, M.. "Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant". Journal of Pathology 194 3 (2001): 358-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034938692&partnerID=MN8TOARS.
    10.1002/path.905
  201. Machado, J.C.; Oliveira, C.; Carvalho, R.; Soares, P.; Berx, G.; Caldas, C.; Seruca, R.; Carneiro, F.; Sobrinho-Simöes, M.. "E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma". Oncogene 20 12 (2001): 1525-1528. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035932396&partnerID=MN8TOARS.
    10.1038/sj.onc.1204234
  202. Barroca, H.; Carvalho, J.L.; Gil da Costa, M.J.; Cirnes, L.; Seruca, R.; Schmitt, F.C.. "Detection of N-myc amplification in neuroblastomas using Southern blotting on fine needle aspirates". Acta Cytologica 45 2 (2001): 169-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035076942&partnerID=MN8TOARS.
  203. Máximo, V.; Soares, P.; Machado, J.C.; Seruca, R.; Sobrinho-Simöes, M.; Habano, W.; Nakamura, S.I.. "Mitochondrial DNA alteration in gastric cancer [5]". Gastroenterology 119 6 (2000): 1808-1809. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034463296&partnerID=MN8TOARS.
  204. Pinto, M.; Oliveira, C.; Machado, J.C.; Cirnes, L.; Tavares, J.; Carneiro, F.; Hamelin, R.; et al. "MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile". Laboratory Investigation 80 12 (2000): 1915-1923. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034535952&partnerID=MN8TOARS.
  205. Alves, C.; Silva, F.; Gusmão, L.; Seruca, R.; Soares, P.; Reis, R.M.; Amorim, A.. "Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: Characterisation in a normal population and in thyroid and gastric tumours". European Journal of Human Genetics 8 7 (2000): 540-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033948475&partnerID=MN8TOARS.
    10.1038/sj.ejhg.5200486
  206. David, L.; Silva, F.; Seruca, R.; Pinto, M.; Reis, C.; Sobrinho-Simoes, M.; Jass, R.J.. "Correspondence re: A. E. Biemer-Huttmann et al., Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin. Cancer res., 6: 1909-1916, 2000 (multiple letters)". Clinical Cancer Research 6 11 (2000): 4461-4462. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033739109&partnerID=MN8TOARS.
  207. Carvalho, B.; Seruca, R.; Carneiro, F.; Buys, C.H.C.M.; Kok, K.. "Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1". Genes Chromosomes and Cancer 26 1 (1999): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032841006&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199909)26:1<29::AID-GCC4>3.0.CO;2-D
  208. Munar-Qués, M.; Pedrosa, J.L.; Coelho, T.; Gusmão, L.; Seruca, R.; Amorim, A.; Sequeiros, J.. "Two pairs of proven monozygotic twins discordant for familial amyloid neuropathy (FAP) TTR Met 30". Journal of Medical Genetics 36 8 (1999): 629-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032803525&partnerID=MN8TOARS.
  209. Carvalho, B.; Seruca, R.; Carneiro, F.; Buys, C.H.C.M.; Kok, K.. "Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1". Genes Chromosomes and Cancer 26 1 (1999): 29-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032841006&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199909)26:1<29::AID-GCC4>3.0.CO;2-D
  210. Schmitt, F.C.; Soares, R.; Gobbi, H.; Milanezzi, F.; Santos-Silva, F.; Cirnes, L.; Costa, C.; Seruca, R.. "Microsatellite instability in medullary breast carcinomas". International Journal of Cancer 84 5 (1999): 644-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033609731&partnerID=MN8TOARS.
  211. Carneiro, F.; Machado, J.C.; Seruca, R.; Sobrinho-Simoes, M.. "E-cadherin changes in gastric carcinoma [2]". Histopathology 35 5 (1999): 477-478. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032731166&partnerID=MN8TOARS.
    10.1046/j.1365-2559.1999.035005477.x
  212. Caldas, C.; Carneiro, F.; Lynch, H.T.; Yokota, J.; Wiesner, G.L.; Powell, S.M.; Lewis, F.R.; et al. "Familial gastric cancer: Overview and guidelines for management". Journal of Medical Genetics 36 12 (1999): 873-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033432725&partnerID=MN8TOARS.
  213. Maximo, V.; Soares, P.; Seruca, R.; Sobrinho-Simoes, M.. "Comments on: Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319". European Journal of Cancer 35 9 (1999): 1407-1408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032766997&partnerID=MN8TOARS.
    10.1016/S0959-8049(99)00126-4
  214. Nogueira, A.M.M.F.; Cameiro, F.; Seruca, R.; Cirnes, L.; Veiga, I.; Machado, J.C.; Sobrinho-Simões, M.. "Microsatellite instability in hyperplastic and adenomatous polyps of the stomach". Cancer 86 9 (1999): 1649-1656. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344631745&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0142(19991101)86:9<1649::AID-CNCR5>3.0.CO;2-N
  215. Nogueira, A.M.M.F.; Cameiro, F.; Seruca, R.; Cirnes, L.; Veiga, I.; Machado, J.C.; Sobrinho-Simões, M.. "Microsatellite instability in hyperplastic and adenomatous polyps of the stomach". Cancer 86 9 (1999): 1649-1656. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344631745&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0142(19991101)86:9<1649::AID-CNCR5>3.0.CO;2-N
  216. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "PCR amplification of DNA obtained from archived hematoxylin-eosin-and giemsa-stained breast cancer aspirates". Diagnostic Cytopathology 19 5 (1998): 395-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031733732&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4
  217. Lopes, J.M.; Silva, P.; Seixas, M.; Cirnes, L.; Seruca, R.. "Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours [4]". Histopathology 33 6 (1998): 579-581. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031646340&partnerID=MN8TOARS.
  218. Zhou, X.-P.; Hoang, J.-M.; Li, Y.-J.; Seruca, R.; Carneiro, F.; Sobrinho-Simoes, M.; Lothe, R.A.; et al. "Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites". Genes Chromosomes and Cancer 21 2 (1998): 101-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031938045&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199802)21:2<101::AID-GCC4>3.0.CO;2-4
  219. Peixoto, A.; Dos Santos, M.R.; Seruca, R.; Amorim, A.; Castedo, S.. "Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: Evidence for a 'protector' haplotype". European Journal of Human Genetics 6 5 (1998): 518-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031734362&partnerID=MN8TOARS.
  220. Gayther, S.A.; Gorringe, K.L.; Ramus, S.J.; Huntsman, D.; Roviello, F.; Grehan, N.; Machado, J.C.; et al. "Identification of germ-line E-cadherin mutations in gastric cancer families of European origin". Cancer Research 58 18 (1998): 4086-4089. http://www.scopus.com/inward/record.url?eid=2-s2.0-19244377605&partnerID=MN8TOARS.
  221. Zhou, X.-P.; Hoang, J.-M.; Li, Y.-J.; Seruca, R.; Carneiro, F.; Sobrinho-Simoes, M.; Lothe, R.A.; et al. "Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites". Genes Chromosomes and Cancer 21 2 (1998): 101-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031938045&partnerID=MN8TOARS.
    10.1002/(SICI)1098-2264(199802)21:2<101::AID-GCC4>3.0.CO;2-4
  222. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "P53 in breast carcinomas: Association between presence of mutation and immunohistochemical expression using a semiquantitative approach". Pathology Research and Practice 194 12 (1998): 815-819. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032437296&partnerID=MN8TOARS.
  223. Schmitt, F.C.; Soares, R.; Seruca, R.. "Bilateral apocrine carcinoma of the breast: Molecular and immunocytochemical evidence for two independent primary tumours". Virchows Archiv 433 6 (1998): 505-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031743447&partnerID=MN8TOARS.
    10.1007/s004280050281
  224. Oliveira, C.; Seruca, R.; Seixas, M.; Sobrinho-Simões, M.. "The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different 'target genes': A study of the TGFß RII, IGFII R, and BAX genes". American Journal of Pathology 153 4 (1998): 1211-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031710793&partnerID=MN8TOARS.
  225. Schmitt, F.C.; Soares, R.; Cirnes, L.; Seruca, R.. "PCR amplification of DNA obtained from archived hematoxylin-eosin-and giemsa-stained breast cancer aspirates". Diagnostic Cytopathology 19 5 (1998): 395-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031733732&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4
  226. Seruca, R.; Sobrinho-Simoes, M.; Hayden, J.D.; Martin, I.G.. "Assessment of microsatellite alterations in young patients with gastric adenocarcinoma [2] (multiple letters)". Cancer 80 7 (1997): 1358-1360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030886947&partnerID=MN8TOARS.
  227. Carvalho, F.; Seruca, R.; David, L.; Amorim, A.; Seixas, M.; Bennett, E.; Clausen, H.; Sobrinho-Simões, M.. "MUC1 gene polymorphism and gastric cancer an epidemiological study". Glycoconjugate Journal 14 1 (1997): 107-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031058867&partnerID=MN8TOARS.
    10.1023/A:1018573201347
  228. Silva, F.; Gusmão, L.; Alves, C.; Seruca, R.; David, L.; Amorim, A.. "Tetra- and pentanucleotide short tandem repeat instability in gastric cancer". Electrophoresis 18 9 (1997): 1633-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030833238&partnerID=MN8TOARS.
    10.1002/elps.1150180926
  229. Soares, P.; Dos Santos, N.R.; Seruca, R.; Lothe, R.A.; Sobrinho-Simo¿s, M.. "Benign and malignant thyroid lesions show instability at microsatellite loci". European Journal of Cancer Part A 33 2 (1997): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030939160&partnerID=MN8TOARS.
    10.1016/S0959-8049(96)00457-1
  230. Seruca, R.; David, L.; Sobrinho-Simões, M.. "Relationship between the expression of p53 and the aggressiveness of gastric carcinoma.". The Journal of pathology 181 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031089801&partnerID=MN8TOARS.
  231. Dos Santos, N.R.; Seruca, R.; Constancia, M.; Seixas, M.; Sobrinho-Simoes, M.. "Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis". Gastroenterology 110 1 (1996): 38-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030061373&partnerID=MN8TOARS.
    10.1053/gast.1996.v110.pm8536886
  232. Gärtner, F.; David, L.; Seruca, R.; Machado, J.C.; Sobrinho-Simões, M.. "Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice". Virchows Archiv 428 2 (1996): 91-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030000111&partnerID=MN8TOARS.
  233. Queimado, L.; Seruca, R.; Costa-Pereira, A.; Castedo, S.. "Identification of two distinct regions of deletion at 6q in gastric carcinoma". Genes Chromosomes and Cancer 14 1 (1995): 28-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029092711&partnerID=MN8TOARS.
    10.1002/gcc.2870140106
  234. Seruca, R.; Constancia, M.; Dos Santos, N.R.; David, L.; Queimado, L.; Carvalho, F.; Carneiro, F.. "Allele loss in human gastric carcinomas: Relation to tumor progression and differentiation". International Journal of Oncology 7 5 (1995): 1159-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557116&partnerID=MN8TOARS.
  235. Seruca, R.; Santos, N.R.; David, L.; Constancia, M.; Barroca, H.; Carneiro, F.; Seixas, M.; et al. "Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile". International Journal of Cancer 64 1 (1995): 32-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028900007&partnerID=MN8TOARS.
    10.1002/ijc.2910640108
  236. Seruca, R.; Suijkerbuijk, R.F.; Gärtner, F.; Criado, B.; Veiga, I.; Olde-Weghuis, D.; David, L.; Castedo, S.; Sobrinho-Simões, M.. "Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer". Cancer Genetics and Cytogenetics 82 2 (1995): 140-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029122417&partnerID=MN8TOARS.
    10.1016/0165-4608(95)00033-L
  237. Criado, B.; Barros, A.; Suijkerbuijk, R.F.; Weghuis, D.O.; Seruca, R.; Fonseca, E.; Castedo, S.. "Detection of numerical alterations for chromosomes 7 and 12 in benign thyroid lesions by in situ hybridization: Histological implications". American Journal of Pathology 147 1 (1995): 136-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029076415&partnerID=MN8TOARS.
  238. De Leeuw, B.; Balemans, M.; Olde Weghuis, D.; Seruca, R.; Janz, M.; Geraghty, M.T.; Gilgenkrantz, S.; Ropers, H.H.; Geurts Van Kessel, A.. "Molecular cloning of the synovial sarcoma-specific translocation (X;18)(p11.2;q11.2) breakpoint". Human Molecular Genetics 3 5 (1994): 745-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028350595&partnerID=MN8TOARS.
    10.1093/hmg/3.5.745
  239. Seruca, R.; David, L.; Castedo, S.; Veiga, I.; Borresen, A.-L.; Sobrinho-Simoes, M.. "p53 Alterations in gastric carcinoma: A study of 56 primary tumors and 204 nodal metastases". Cancer Genetics and Cytogenetics 75 1 (1994): 45-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028167782&partnerID=MN8TOARS.
    10.1016/0165-4608(94)90214-3
  240. Carneiro, F.; Seruca, R.; Ribeiro, A.C.; Simoes, M.S.; Teh, M.; Yoke Sun Lee. "An immunohistochemical study of ras oncoprotein expression in gastric carcinoma [6]". Cancer 73 7 (1994): 2010-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028206692&partnerID=MN8TOARS.
    10.1002/1097-0142(19940401)73:7<2010::AID-CNCR2820730741>3.0.CO;2-7
  241. Constância, M.; Seruca, R.; Carneiro, F.; Silva, F.; Castedo, S.. "Retinoblastoma gene structure and product expression in human gastric carcinomas". British Journal of Cancer 70 5 (1994): 1018-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027949365&partnerID=MN8TOARS.
    10.1038/bjc.1994.441
  242. Lopes, J.M.; Seruca, R.; Sobrinho-Simões, M.. "Critical Commentary". Pathology Research and Practice 189 4 (1993): 473-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0004552908&partnerID=MN8TOARS.
    10.1016/S0344-0338(11)80341-9
  243. Seruca, R.; Castedo, S.; Correia, C.; Gomes, P.; Carneiro, F.; Soares, P.; de Jong, B.; Sobrinho-Simões, M.. "Cytogenetic findings in eleven gastric carcinomas". Cancer Genetics and Cytogenetics 68 1 (1993): 42-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027283862&partnerID=MN8TOARS.
    10.1016/0165-4608(93)90072-T
  244. Peltomaki, P.; Lothe, R.A.; Aaltonen, L.A.; Pylkkanen, L.; Nystrom-Lahti, M.; Seruca, R.; David, L.; et al. "Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome". Cancer Research 53 24 (1993): 5853-5855. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027140481&partnerID=MN8TOARS.
  245. Carneiro, F.; David, L.; Seruca, R.; Castedo, S.; Nesland, J.M.; Sobrinho-Simoes, M.. "Hyperplastic polyposis and diffuse carcinoma of the stomach: A study of a family". Cancer 72 2 (1993): 323-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027154614&partnerID=MN8TOARS.
    10.1002/1097-0142(19930715)72:2<323::AID-CNCR2820720204>3.0.CO;2-G
  246. Lothe, R.A.; Saeter, G.; Danielsen, H.E.; Stenwig, A.E.; Hoyheim, B.; O'Connell, P.O.; Borresen, A.-L.; et al. "Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)". Pathology Research and Practice 189 4 (1993): 465-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027159475&partnerID=MN8TOARS.
  247. David, L.; Seruca, R.; Nesland, J.M.; Soares, P.; Sansonetty, F.; Holm, R.; Børresen, A.L.; Sobrinho-Simões, M.. "c-erbB-2 expression in primary gastric carcinomas and their metastases.". Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 5 4 (1992): 384-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026886442&partnerID=MN8TOARS.
  248. Castedo, S.; Correia, C.; Gomes, P.; Seruca, R.; Soares, P.; Carneiro, F.; Sobrinho-Simões, M.. "Loss of Y chromosome in gastric carcinoma. Fact or artifact?". Cancer Genetics and Cytogenetics 61 1 (1992): 39-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026688768&partnerID=MN8TOARS.
    10.1016/0165-4608(92)90367-H
  249. Seruca, R.; David, L.; Holm, R.; Nesland, J.M.; Fangan, B.M.; Castedo, S.; Sobrinho-Simoes, M.; Borresen, A.-L.. "P53 mutations in gastric carcinomas". British Journal of Cancer 65 5 (1992): 708-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026523480&partnerID=MN8TOARS.
    10.1038/bjc.1992.149
  250. Seruca, R.; Carneiro, F.; Soares, P.; Fonseca, E.; Castedo, S.. "Clonal cytogenetic abnormalities and telomeric associations in a fibroxanthoma of the stomach". Genes Chromosomes and Cancer 5 4 (1992): 407-409. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026719445&partnerID=MN8TOARS.
    10.1002/gcc.2870050418
  251. Seruca, R.; Carneiro, F.; Castedo, S.; David, L.; Lopes, C.; Sobrinho-Simoes, M.. "Familial gastric polyposis revisited: Autosomal dominant inheritance confirmed". Cancer Genetics and Cytogenetics 53 1 (1991): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025829590&partnerID=MN8TOARS.
    10.1016/0165-4608(91)90119-F
  252. Lopes, JosM.; Seruca, R.; Hall, A.P.; Branco, P.; Castedo, S.M.M.J.. "Cytogenetic study of a sclerosing stromal tumor of the ovary". Cancer Genetics and Cytogenetics 49 1 (1990): 103-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025052149&partnerID=MN8TOARS.
    10.1016/0165-4608(90)90169-B
  253. Molenaar, W.M.; DeJong, B.; Buist, J.; Idenburg, V.J.S.; Seruca, R.; Vos, A.M.; Hoekstra, H.J.. "Chromosomal analysis and the classification of soft tissue sarcomas". Laboratory Investigation 60 2 (1989): 266-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024581053&partnerID=MN8TOARS.
  254. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Te Meerman, G.J.; Dam, A.; Koops, H.S.. "Cytogenetic analysis of ten human seminomas". Cancer Research 49 2 (1989): 439-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024545210&partnerID=MN8TOARS.
  255. Oosterhuis, J.W.; Castedo, S.M.M.J.; De Jong, B.; Seruca, R.; Dam, A.; Vos, A.; De Koning, J.; Schraffordt Koops, H.; Sleijfer, D.T.. "A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases". Cancer Genetics and Cytogenetics 41 1 (1989): 105-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024441365&partnerID=MN8TOARS.
    10.1016/0165-4608(89)90114-3
  256. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Idenburg, V.J.S.; Seruca, R.; Buist, J.; Te Meerman, G.J.; Schraffordt Koops, H.; Sleijfer, D.T.. "Chromosomal changes in mature residual teratomas following polychemotherapy". Cancer Research 49 3 (1989): 672-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024592021&partnerID=MN8TOARS.
  257. Castedo, S.M.M.J.; De Jong, B.; Wolter Oosterhuis, J.; Seruca, R.; Idenburg, V.J.S.; Dam, A.; Te Meerman, G.; Schraffordt Koops, H.; Sleijfer, D.T.. "Chromosomal changes in human primary testicular nonseminomatous germ cell tumors". Cancer Research 49 20 (1989): 5696-5701. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024457239&partnerID=MN8TOARS.
  258. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Idenburg, V.J.; Buist, J.; Sleijfer, D.T.. "i(12p)-Negative testicular germ cell tumors. A different group?". Cancer Genetics and Cytogenetics 35 2 (1988): 171-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024237328&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90239-7
  259. Oosterhuis, J.W.; Castedo, S.M.M.J.; De Jong, B.; Seruca, R.; Buist, J.; Schraffordt Koops, H.; Leeuw, J.B.. "Karyotyping and DNA flow cytometry of an orchidoblastoma". Cancer Genetics and Cytogenetics 36 1 (1988): 7-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024244063&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90069-6
  260. Castedo, S.M.M.J.; Seruca, R.; Oosterhuis, J.W.; De Jong, B.; Schraffordt Koops, H.; Leeuw, J.A.. "Cytogenetics of a case of osteosarcoma". Cancer Genetics and Cytogenetics 32 1 (1988): 149-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023884810&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90322-6
  261. Castedo, S.M.M.J.; De Jong, B.; Oosterhuis, J.W.; Seruca, R.; Buist, J.; Schraffordt Koops, H.. "Cytogenetic study of a combined germ cell tumor of the testis". Cancer Genetics and Cytogenetics 35 2 (1988): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024204378&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90237-3
  262. Castedo, S.M.M.J.; Oosterhuis, J.W.; De Jong, B.; Seruca, R.; Dam, A.; Buist, J.; Schraffordt Koops, H.; Sleijfer Th., D.. "A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma?". Cancer Genetics and Cytogenetics 32 1 (1988): 51-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023932663&partnerID=MN8TOARS.
    10.1016/0165-4608(88)90311-1
Capítulo de livro
  1. Fernandes, M.S.; Sanches, J.M.; Seruca, R.. "Targeting the PI3K signalling as a therapeutic strategy in colorectal cancer". 35-53. 2018.
    10.1007/978-3-030-02771-1_4
  2. Fernandes, M.S.; Ferro, A.; Carneiro, P.; Seruca, R.; Sanches, J.M.. "Quantum dots: Concepts, imaging, and therapeutic applications in cancer". 105-118. 2017.
  3. Figueiredo, J.; Ribeiro, A.S.; Mestre, T.; Esménio, S.; Fonseca, M.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Capturing quantitative features of protein expression from in situ fluorescence microscopic images of cancer cell populations". 279-297. 2017.
  4. Ferro, A.; Carneiro, P.; Fernandes, M.S.; Mestre, T.; Sanches, J.M.; Seruca, R.. "Illuminating the cycle of life". 201-230. 2017.
Livro
  1. Seruca, R.; Suri, J.S.; Sanches, J.M.. Preface. 2017.
  2. Seruca, R.; Suri, J.S.; Sanches, J.M.. Fluorescence Imaging and Biological Quantification. 2017.
    10.1201/9781315121017
  3. Figueiredo, J.; Seruca, R.. Germline missense mutants in hereditary diffuse gastric cancer. 2013.
    10.1007/978-94-007-6570-2_7
  4. Leite, M.; Corso, G.; Sousa, S.; Carvalho, J.; Roviello, F.; Oliveira, C.; Figueiredo, C.; Seruca, R.. Non- CDH1 -associated familial gastric cancer and epigenetics factors. 2013.
    10.1007/978-94-007-6570-2_10
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2016 - Atual Influence of ECM components on cancer stem-like properties
Orientador de Ana Margarida Moreira
 Molecular and Cellular Biotechnology Applied to Health Sciences (Doutoramento)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2021/01/26 Diagnose cancer-causative E-cadherin missense mutations through molecular and morphological changes involved in cell extrusion
Orientador de Soraia Melo
 Biomedicine (Doutoramento)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2012 PhD Joana Figueiredo
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2012 PhD Giovanni Corso
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2011 PhD Joana Caldeira Fernandes
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2006 - 2010 PhD Sérgia Velho
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009 PhD Rita Mateus
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2009 PhD Joana Correia
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2003 - 2009 PhD Filipe Jacinto
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2000 - 2004 PhD Mafalda Pinto
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
1998 - 2002 PhD Carla Oliveira
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
1997 - 2001 PhD Beatriz Carvalho
Orientador
Universidade do Porto Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2015 - 2015 Organizing Committee Member - XXIII Porto Cancer Meeting (2015 - 2015)
Congresso (Membro da Comissão Organizadora)
2007 - 2007 Organizing Committee Member - Reunião Anual SPGH (2007 - 2007)
Congresso (Membro da Comissão Organizadora)
2004 - 2004 Organizing Committee Member - XIII Porto Cancer Meeting (2004 - 2004)
Congresso (Membro da Comissão Organizadora)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2011 - 2012 Coordinator of the Biomedicine and Basic Medicine panel of PhD and Postdoctoral Grants
Outro
 Fundação para a Ciência e a Tecnologia
2008 - 2010 International Evaluator of European Projects within 7th Framework funding programme (FP7) and Marie Curie grants.
Avaliador
 European Commission, Bélgica

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2001 - Atual Member of the Scientific Advisory Council of the American Association "No Stomach for Cancer".
2009 - 2013 Scientific Advisory Board Member of "Conselho Nacional de Ética para as Ciências da Vida", Assembleia da República Portuguesa Assembleia da República Portuguesa, Portugal
2009 - 2013 Member of the external Scientific Committee at the "Institute of Predictive and Personalized Medicine of Cancer, Universitat Autònoma de Barcelona - Campus of International Excellence/UAB-CIE Universitat Autònoma de Barcelona, Espanha
2005 - 2008 Member of the Scientific Programme Committee, European Society of Human Genetics

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2009 - Atual Lecturer of the Oncobiology Module of Doctoral Programme in Biomedicine Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007 - Atual Lecturer of the Oncobiology Module of Doctoral Programme in Pathology and Molecular Genetics Oncobiologia (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - Atual Lecturer of the Oncobiology Module of Doctoral Programme in Molecular and Oncology Medicine Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2006 - Atual Affiliated Professor Biological/Molecular mechanisms of cancer development and progession Universidade do Porto Faculdade de Medicina, Portugal
2004 - Atual Lecturer of the Oncobiology Module of Msc Programme in Molecular and Oncology Medicine Oncobiologia Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2018 Lecturer of the Oncobiology Module of GABBA Doctoral Programme Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2008 - 2015 Coordinator of the Oncobiology Module of GABBA Doctoral Programme Oncobiologia (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Membro de associação

Nome da associação Tipo de participação
2012 - Atual Member of Portuguese Association for Cancer Research - ASPIC
2007 - 2007 President of the Portuguese Human Genetics Society

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - 2019 Installing Committee Member of "Agência de Investigação Clínica e Inovação Biomédica"
Membro
2008 - 2011 Scientific Committee Member of the Gulbenkian Programme in collaboration with Champalimaud Foundation for Advanced Medical Training.
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2007 - 2017 Evaluator of PhD and Postdoctoral grants for the Portuguese Foundation for Science and Technology (FCT). Fundação para a Ciência e a Tecnologia, Portugal

Tutoria

Tópico Nome do aluno
2006 - 2010 Ombudsperson at IPATIMUP Students and staff
Distinções

Outra distinção

2014 Medalha de Ouro de Mérito Cientifico
2009 Ordem do Infante D. Henrique
Palácio do Planalto, Brasil
2005 Estímulo à Excelência
2003 Prémio Labmed
2002 Prémio Labmed
2002 Benjamin Castelman Award
United States and Canadian Academy of Pathology, Estados Unidos
2002 Primeiro Prémio Sociedade Portuguesa de Genética