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Vilma A. Sardão is an Assistant Investigator at the Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra. She graduated in Biochemistry from the University of Coimbra in 2002 and obtained her Ph.D. in Cell Biology in 2008 at the same University. During her Ph.D. and Postdoc, she had 47 months of International experience at the University of Minnesota-Duluth, USA. She has gathered robust technical laboratory know-how in mitochondrial physiology and respirometry, cell culture, western blot, microscopy, and other cellular and molecular biology methods. Vilma A. Sardão has been focusing her career on mitochondria's role in cell physiology, pathology, and toxicology (>40 published papers). Her scientific background allowed her to establish national and international collaborations in interdisciplinary fields. Her scientific interests focus on mitochondrial remodeling during hormonal status alteration after menopause and the associated development of menopause-associated pathologies. Vilma has currently 53 publications in international peer-reviewed journals (22 in Q1 journals, 14 as first/last author, >1522-2330 citations, h-index 22-27, source: Web of Science/Google Scholar), six book chapters, 21 invited oral communications, more than 40 selected oral communications, and more than 85 posters in national and international conferences. She also obtained some scientific prizes, including the award for student Merit from the University of Coimbra (2002), the Aventis Prize for Scientific Research (2003), and the Graduate Student/Postdoc award, endorsed by the Society for Heart and Vascular Metabolism, 2006.
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Identificação

Identificação pessoal

Nome completo
Vilma Marisa Arrojado Soares Sardão Oliveira
Data de nascimento
1979/09/20
Género
Feminino

Nomes de citação

  • Sardão, Vilma

Identificadores de autor

Ciência ID
AF11-AF31-4912
ORCID iD
0000-0001-7014-4614
Researcher Id
A-1546-2012

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2008/02/18
Concluído
 Biology (Doutoramento)
Especialização em Cellular Biology
University of Coimbra - Faculty of Sciences and Technology, Portugal
"H9c2 Myoblasts as a Tool to Study Doxorubicin-induced Cardiomyopathy - Mechanisms of Cell Death and relevance of Differentiation State" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade com distinção e louvor
2002/06/27
Concluído
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A Toxicicidade da Cafeína ao Nível da Função Mitocondrial Cardíaca" (TESE/DISSERTAÇÃO)
 16 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/11/01 - 2021/10/31 Investigador Contratado (Investigação) University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
2003/02/01 - 2016/10/31 Investigador (Investigação) Fundação Para a Ciência e Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2001/09/01 - 2002/12/31 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
Projetos

Bolsa

Designação Financiadores
2015/10/01 - 2016/10/31 stemPREDICT: Bioenergetic Health Index in Human Urine-derived Stem Cells: Role for Differentiation Outcome and Chemical-induced Toxicity
SFRH/BDP/109339/2015
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2014/05/01 - 2015/09/30 Stemcell based platforms for Regenerative and Therapeutic Medicine
CENTRO-07-ST24-FEDER-002008
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008/03/01 - 2014/05/31 Role Of Estrogens In Breast Cancer Cells: Mechanism Of Estrogen-Indiced Breast Cancer Cell Proliferation And Effects Of Hormone Replacement Therapy In Cancer Development
SFRH/BPD/31549/2006
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/09 - 2010/03 Novel Mitochondrial Mechanisms of Doxorubicin-induced Selective Cardiotoxicity
grant.Provided by PTCRIS: 64084
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2022/01/04 - Atual Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - Atual Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley
COA/BRB/0019/2019
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/12/01 - Atual VALORYZEBYPRODUCTS: Preclinical efficacy of sulforaphane or Brassica whole extract: a strategy to fight obesity and valorize Brassica byproduts
PTDC/ASP-HOR/29152/2017
Investigador
Fundação Para a Ciência e Tecnologia
Concluído
2018/05/01 - Atual MitoScreening: Development and validation of innovative screening methods for mitochondrial health modulators
PTDC/BTM-SAL/29297/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação Para a Ciência e Tecnologia
Em curso
2017/06 - 2021/10 MitoBone – Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation
IF/01182/2015
IF/01182/2015
Investigador responsável
Fundação Para a Ciência e Tecnologia
Em curso
2016/09/01 - 2019/06/30 FishFree: Uma contribuição para a validação de um ensaio alternativo ao teste letal com peixes
PTDC/AAG-TEC/4966/2014
Investigador
Universidade de Coimbra, Portugal
 Fundação Para a Ciência e Tecnologia
Concluído
2015 - 2018 MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria
PTDC/DTP-FTO/2433/2014
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Em curso
2014/05 - 2015/09 Stemcell based platforms for Regenerative and Therapeutic Medicine
CENTRO- 07-ST24-FEDER-002008
CENTRO- 07-ST24-FEDER-002008
PTDC/DTP-FTO/2433/2014
Bolseiro de Pós-Doutoramento
N/A
Concluído
2013/05 - 2015/08 Pathophysiology of Persistent Doxorubicin Cardiotoxicity: a Mitochondrial-Epigenetics Link
grant.Provided by PTCRIS: 126115
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
grant.Provided by PTCRIS: 108326
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/06 Role of Mitochondrial Physiology in Tumor Stem Cell Resistance to Chemotherapeutics
grant.Provided by PTCRIS: 101052
Investigador
Fundação para a Ciência e a Tecnologia
2010/04 - 2013/03 Opening Pandora's Box for Active Anti-Breast Cancer Therapy - The Role of Selective Targeting to Mitochondria
grant.Provided by PTCRIS: 101409
Investigador
Fundação para a Ciência e a Tecnologia
2007/11 - 2010/04 Influence of Cell Differentiation State on Apoptosis Induced by Isoproterenol on Embryonic Ventricular H9c2 Cells - Signalling Pathways Involved
grant.Provided by PTCRIS: 64358
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Cláudia Bessa; Joana B. Loureiro; Matilde Barros; Vera M. S. Isca; Vilma A. Sardão; Paulo J. Oliveira; Raquel L. Bernardino; et al. "Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCd Activator". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24065710.
    10.3390/ijms24065710
  2. José P. Castelão-Baptista; Sara A. Valente; Sara Canário; David Oppolzer; Ana Barros; Carlos Venâncio; Tânia Martins; et al. "Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity". Nutrients (2023): https://doi.org/10.3390/nu15040924.
    10.3390/nu15040924
  3. Ana Pedrosa; Guilherme Furtado; Marcelo Paes de Barros; André Luís Lacerda Bachi; José Pedro Ferreira; Vilma A. Sardão; Luís Rama; Ana Teixeira. "The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglobin Levels in Type 2 Diabetes Patients". Diabetology (2022): https://doi.org/10.3390/diabetology4010002.
    10.3390/diabetology4010002
  4. Alves-Silva, Jorge M.; Zuzarte, Mónica; Marques, Carla; Viana, Sofia; Preguiça, Inês; Baptista, Rui; Ferreira, Cátia; et al. "1,8-cineole Ameliorates Right Ventricle Dysfunction Associated With Pulmonary Arterial Hypertension by Restoring Connexin 43 and Mitochondrial Homeostasis". Pharmacological Research (2022): 106151. http://dx.doi.org/10.1016/j.phrs.2022.106151.
    10.1016/j.phrs.2022.106151
  5. Giampaolo Morciano; Natalia Naumova; Piotr Koprowski; Sara Valente; Vilma A. Sardão; Yaiza Potes; Alessandro Rimessi; Mariusz R. Wieckowski; Paulo J. Oliveira. "The mitochondrial permeability transition pore: an evolving concept critical for cell life and death". Biological Reviews (2021): https://doi.org/10.1111/brv.12764.
    10.1111/brv.12764
  6. Emilio Molina-Molina; Guilherme E. Furtado; John G. Jones; Piero Portincasa; Ana Vieira-Pedrosa; Ana Maria Teixeira; Marcelo P. Barros; André L. Bachi; Vilma A. Sardão. "The advantages of physical exercise as a preventive strategy against NAFLD in Postmenopausal Women". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13731.
    10.1111/eci.13731
  7. Dias-Pedroso, Daniela; Ramalho, José S.; Sardão, Vilma A.; Jones, John G.; Romão, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L.A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02630-4.
    10.1007/s12035-021-02630-4
  8. José P. Castelão-Baptista; A.I.R.N.A.Barros; Tânia Martins; Eduardo Rosa; Vilma A. Sardão. "Three in One: The Potential of Brassica By-Products against Economic Waste, Environmental Hazard, and Metabolic Disruption in Obesity". Nutrients (2021): https://www.mdpi.com/2072-6643/13/12/4194.
    10.3390/nu13124194
  9. Bruno M. Moukette; José P. Castelão-Baptista; Luciana Ferreira; Ana M. Silva; Rui F. Simões; Célia Cabral; Constant A. Pieme; et al. "Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 Cardiomyoblasts". Evidence-Based Complementary and Alternative Medicine (2021): https://doi.org/10.1155/2021/8858165.
    10.1155/2021/8858165
  10. Cardoso, Henrique J.; Figueira, Marília I.; Vaz, Cátia V.; Carvalho, Tiago M. A.; Brás, Luís A.; Madureira, Patrícia A.; Oliveira, Paulo J.; Sardão, Vilma; Socorro, Sílvia. "Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation". Cellular Oncology (2021): http://dx.doi.org/10.1007/s13402-020-00575-9.
    10.1007/s13402-020-00575-9
  11. Guilherme Eustáquio Furtado; Rubens Vinícius Letieri; Adriana Caldo; Vilma Sardão; Ana Maria Teixeira; Marcelo Paes de Barros; Rodolfo Paula Vieira; André Luís Lacerda Bachi. "Sustaining efficient immune functions with regular physical exercise in the COVID-19 era and beyond". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13485.
    10.1111/eci.13485
  12. Sousa, Bárbara; Pereira, Joana; Marques, Ricardo; Grilo, Luís F.; Pereira, Susana P.; Sardão, Vilma A.; Schmitt, Fernando; Oliveira, Paulo J.; Paredes, Joana. "P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 12 (2020): 165964. http://dx.doi.org/10.1016/j.bbadis.2020.165964.
    10.1016/j.bbadis.2020.165964
  13. Serafim, Teresa L.; Cunha-Oliveira, Teresa; Deus, Claudia M.; Sardão, Vilma A.; Cardoso, Ines M.; Yang, Shanshan; Odhiambo, John F.; et al. "Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity". European Journal of Clinical Investigation (2020): http://dx.doi.org/10.1111/eci.13375.
    10.1111/eci.13375
  14. Kim, Ha-Neui; Ponte, Filipa; Nookaew, Intawat; Ucer Ozgurel, Serra; Marques-Carvalho, Adriana; Iyer, Srividhya; Warren, Aaron; et al. "Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-68890-7.
    Publicado • 10.1038/s41598-020-68890-7
  15. Wallace, Kendall B.; Sardão, Vilma A.; Oliveira, Paulo J.. "Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy". Circulation Research 126 7 (2020): 926-941. http://dx.doi.org/10.1161/circresaha.119.314681.
    10.1161/circresaha.119.314681
  16. Bento, Guida; Shafigullina, Aygul K.; Rizvanov, Albert A.; Sardão, Vilma A.; Macedo, Maria Paula; Oliveira, Paulo J.. "Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine". Cells 9 3 (2020): 573. http://dx.doi.org/10.3390/cells9030573.
    10.3390/cells9030573
  17. Rodrigues, Elsa T.; Varela, Ana T.; Pardal, Miguel A.; Sardão, Vilma A.. "Cell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals". Environmental Science and Pollution Research (2019): http://dx.doi.org/10.1007/s11356-019-07384-0.
    10.1007/s11356-019-07384-0
  18. Veloso, Caroline D.; Belew, Getachew D.; Ferreira, Luciana L.; Grilo, Luís F.; Jones, John G.; Portincasa, Piero; Sardão, Vilma A.; Oliveira, Paulo J.. "A Mitochondrial Approach to Cardiovascular Risk and Disease". Current Pharmaceutical Design 25 29 (2019): 3175-3194. http://dx.doi.org/10.2174/1389203720666190830163735.
    10.2174/1389203720666190830163735
  19. Grasselli, Elena; Baldini, Francesca; Vecchione, Giulia; Oliveira, Paulo; Sard¿o, Vilma; Voci, Adriana; Portincasa, Piero; Vergani, Laura. "Excess fructose and fatty acids trigger a model of non-alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin". International Journal of Molecular Medicine (2019): http://dx.doi.org/10.3892/ijmm.2019.4234.
    10.3892/ijmm.2019.4234
  20. Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; et al. "Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells". Cell Metabolism 29 2 (2019): 399-416.e10. http://dx.doi.org/10.1016/j.cmet.2018.10.014.
    10.1016/j.cmet.2018.10.014
  21. Giorgi, Carlotta; Marchi, Saverio; Simoes, Ines C.M.; Ren, Ziyu; Morciano, Giampaolo; Perrone, Mariasole; Patalas-Krawczyk, Paulina; et al. "Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases". International Review of Cell and Molecular Biology 340 (2018): 209-344. http://dx.doi.org/10.1016/bs.ircmb.2018.05.006.
    Publicado • 10.1016/bs.ircmb.2018.05.006
  22. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Soares, Pedro; Datta, Sandipan; Cortopassi, Gino A; Serafim, Teresa L; et al. "Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.". Toxicology 393 (2018): 123-139. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:29141199&KeyUID=MEDLINE:29141199.
    10.1016/j.tox.2017.11.014
  23. Vecchione, Giulia; Grasselli, Elena; Cioffi, Federica; Baldini, Francesca; Oliveira, Paulo J.; Sardao, Vilma A.; Cortese, Katia; et al. "The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression". Frontiers in Nutrition 4 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411196400001&KeyUID=WOS:000411196400001.
    10.3389/fnut.2017.00042
  24. Wojtala, Aleksandra; Karkucinska-Wieckowska, Agnieszka; Sardao, Vilma A.; Szczepanowska, Joanna; Kowalski, Pawel; Pronicki, Maciej; Duszynski, Jerzy; Wieckowski, Mariusz R.. "Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway". Mitochondrion 37 (2017): 62-79. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000416296000008&KeyUID=WOS:000416296000008.
    10.1016/j.mito.2017.07.002
  25. Moreira, Ana C.; Silva, Ana M.; Branco, Ana F.; Baldeiras, Ines; Peteira, Goncalo C.; Seica, Raquel; Santos, Maria S.; Sardao, Vilma A.. "Phytoestrogen coumestrol improves mitochondrial activity and decreases oxidative stress in the brain of ovariectomized Wistar-Han rats". Journal of Functional Foods 34 (2017): 329-339. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403383800036&KeyUID=WOS:000403383800036.
    10.1016/j.jff.2017.05.002
  26. Branco, Ana F.; Ferreira, André; Simões, Rui F.; Magalhães-Novais, Sílvia; Zehowski, Cheryl; Cope, Elisabeth; Silva, Ana Marta; et al. "Ketogenic diets: from cancer to mitochondrial diseases and beyond". European Journal of Clinical Investigation 46 3 (2016): 285-298. http://dx.doi.org/10.1111/eci.12591.
    Publicado • 10.1111/eci.12591
  27. Deus, C.M.; Serafim, T.L.; Magalhães-Novais, S.; Vilaça, A.; Moreira, A.C.; Sardão, V.A.; Cardoso, S.M.; Oliveira, P.J.. "Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells". Archives of Toxicology (2016): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976428138&partnerID=MN8TOARS.
    10.1007/s00204-016-1784-x
  28. Jiménez-Chillarón, J.C.; Nijland, M.J.; Ascensão, A.A.; Sardão, V.A.; Magalhães, J.; Hitchler, M.J.; Domann, F.E.; Oliveira, P.J.. "Back to the future: Transgenerational transmission of xenobiotic-induced epigenetic remodeling". Epigenetics 10 4 (2015): 259-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927770406&partnerID=MN8TOARS.
    10.1080/15592294.2015.1020267
  29. Ferreira, A.; Serafim, T.L.; Sardão, V.A.; Cunha-Oliveira, T.. "Role of mtDNA-related mitoepigenetic phenomena in cancer". European Journal of Clinical Investigation 45 s1 (2015): 44-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919393955&partnerID=MN8TOARS.
    10.1111/eci.12359
  30. Moreira, A.C.; Branco, A.F.; Sampaio, S.F.; Cunha-Oliveira, T.; Martins, T.R.; Holy, J.; Oliveira, P.J.; Sardão, V.A.. "Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 12 (2014): 2468-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910051188&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.09.015
  31. Branco, A.F.; Moreira, A.C.; Cunha-Oliveira, T.; Couto, R.; Sardão, V.A.; Rizvanov, A.A.; Palotás, A.; Oliveira, P.J.. "ß-adrenergic over-stimulation and cardio-myocyte apoptosis: Two receptors, one organelle, two fates?". Current Drug Targets 15 10 (2014): 956-964. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925936688&partnerID=MN8TOARS.
  32. Moreira, A.C.; Silva, A.M.; Santos, M.S.; Sardão, V.A.. "Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown". Journal of Steroid Biochemistry and Molecular Biology 143 (2014): 61-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896338551&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2014.01.016
  33. Oliveira, M.M.; Teixeira, J.C.; Vasconcelos-Nóbrega, C.; Felix, L.M.; Sardão, V.A.; Colaço, A.A.; Oliveira, P.A.; Peixoto, F.P.. "Mitochondrial and liver oxidative stress alterations induced by N-butyl-N-(4-hydroxybutyl)nitrosamine: Relevance for hepatotoxicity". Journal of Applied Toxicology 33 6 (2013): 434-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876712347&partnerID=MN8TOARS.
    10.1002/jat.1763
  34. Branco, A.F.; Sampaio, S.F.; Wieckowski, M.R.; Sardão, V.A.; Oliveira, P.J.. "Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: Differential activation of stress and survival pathways". International Journal of Biochemistry and Cell Biology 45 11 (2013): 2379-2391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883513016&partnerID=MN8TOARS.
    10.1016/j.biocel.2013.08.006
  35. Moreira, A.C.; Silva, A.M.; Santos, M.S.; Sardão, V.A.. "Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of gender". Food and Chemical Toxicology 53 (2013): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871464946&partnerID=MN8TOARS.
    10.1016/j.fct.2012.11.031
  36. Branco, A.F.; Sampaio, S.F.; Moreira, A.C.; Holy, J.; Wallace, K.B.; Baldeiras, I.; Oliveira, P.J.; Sardão, V.A.. "Differentiation-dependent doxorubicin toxicity on h9c2 cardiomyoblasts". Cardiovascular Toxicology 12 4 (2012): 326-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870546889&partnerID=MN8TOARS.
    10.1007/s12012-012-9177-8
  37. Branco, Ana F.; Pereira, Sandro L.; Moreira, Ana C.; Holy, Jon; Sardão, Vilma A.; Oliveira, Paulo J.. "Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line". Cardiovascular Toxicology 11 3 (2011): 191-203. http://dx.doi.org/10.1007/s12012-011-9111-5.
    10.1007/s12012-011-9111-5
  38. Alves, M.G.; MacHado, N.G.; Sardão, V.A.; Carvalho, R.A.; Oliveira, P.J.. "Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion". Journal of Cellular Biochemistry 112 12 (2011): 3872-3881. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055000219&partnerID=MN8TOARS.
    10.1002/jcb.23320
  39. Sardão, V.; Rose-Hellekant, T.; Perkins, E.; Greene, A.; Holy, J.. "Measuring reciprocal regulation of mesenchymal stem cell and tumor cell motility in two and three dimensions in vitro". Stem Cell Research Journal 3 4 (2011): 281-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879738670&partnerID=MN8TOARS.
  40. Ascensão, A.; Lumini-Oliveira, J.; Machado, N.G.; Ferreira, R.M.; Gonçalves, I.O.; Moreira, A.C.; Marques, F.; et al. "Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats". Clinical Science 120 1 (2011): 37-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650871083&partnerID=MN8TOARS.
    10.1042/CS20100254
  41. Pereira, S.L.; Ramalho-Santos, J.; Branco, A.F.; Sardão, V.A.; Oliveira, P.J.; Carvalho, R.A.. "Metabolic remodeling during H9c2 myoblast differentiation: Relevance for in vitro toxicity studies". Cardiovascular Toxicology 11 2 (2011): 180-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958056642&partnerID=MN8TOARS.
    10.1007/s12012-011-9112-4
  42. Silva, J.P.; Sardão, V.A.; Coutinho, O.P.; Olveira, P.J.. "Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death". Cardiovascular Toxicology 10 1 (2010): 51-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951143286&partnerID=MN8TOARS.
    10.1007/s12012-010-9062-2
  43. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts". Cancer Chemotherapy and Pharmacology 64 4 (2009): 811-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169047&partnerID=MN8TOARS.
    10.1007/s00280-009-0932-x
  44. Pereira, C.V.; Moreira, A.C.; Pereira, S.P.; Machado, N.G.; Carvalho, F.S.; Sardão, V.A.; Oliveira, P.J.. "Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety?". Current Drug Safety 4 1 (2009): 34-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-63249131066&partnerID=MN8TOARS.
    10.2174/157488609787354440
  45. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets". Cell Biology and Toxicology 25 3 (2009): 227-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349167673&partnerID=MN8TOARS.
    10.1007/s10565-008-9070-1
  46. Serafim, T.L.; Oliveira, P.J.; Sardao, V.A.; Perkins, E.; Parke, D.; Holy, J.. "Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line". Cancer Chemotherapy and Pharmacology 61 6 (2008): 1007-1018. http://www.scopus.com/inward/record.url?eid=2-s2.0-41049098849&partnerID=MN8TOARS.
    10.1007/s00280-007-0558-9
  47. Serafim, T.L.; Matos, J.A.C.; Sardão, V.A.; Pereira, G.C.; Branco, A.F.; Pereira, S.L.; Parke, D.; et al. "Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells-Nuclear vs. mitochondrial effects". Biochemical Pharmacology 76 11 (2008): 1459-1475. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949119796&partnerID=MN8TOARS.
    10.1016/j.bcp.2008.07.013
  48. Sardão, V.A.; Pereira, S.L.; Oliveira, P.J.. "Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury". Expert Opinion on Drug Safety 7 2 (2008): 129-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349119625&partnerID=MN8TOARS.
    10.1517/14740338.7.2.129
  49. Sardão, V.A.; Oliveira, P.J.; Holy, J.; Oliveira, C.R.; Wallace, K.B.. "Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide - Characterization of morphological features of cell death". BMC Cell Biology 8 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-33947598915&partnerID=MN8TOARS.
    10.1186/1471-2121-8-11
  50. Pereira, G.C.; Branco, A.F.; Matos, J.A.C.; Pereira, S.L.; Parke, D.; Perkins, E.L.; Serafim, T.L.; et al. "Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: Comparison with direct effects on isolated mitochondrial fractions". Journal of Pharmacology and Experimental Therapeutics 323 2 (2007): 636-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548974344&partnerID=MN8TOARS.
    10.1124/jpet.107.128017
  51. Fiuza, S.M.; Amado, A.M.; Oliveira, P.J.; Sardão, V.A.; Batista De Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) vs Pd(II) polyamine complexes as new anticancer drugs: A structure-activity study". Letters in Drug Design and Discovery 3 3 (2006): 149-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645876182&partnerID=MN8TOARS.
    10.2174/157018006776286989
  52. Ferreira, M.; Coxito, P.M.; Sardão, V.A.; Palmeira, C.M.; Oliveira, P.J.. "Bile acids are toxic for isolated cardiac mitochondria: A possible cause for hepatic-derived cardiomyopathies?". Cardiovascular Toxicology 5 1 (2005): 63-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544374442&partnerID=MN8TOARS.
  53. Oliveira, P.J.; Seica, R.; Santos, D.L.; Rolo, A.P.; Sardao, V.A.; Ferreira, F.M.L.; Palmeira, C.M.; Santos, M.S.; Moreno, A.J.M.. "Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats". Mitochondrion 3 6 (2004): 337-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484378&partnerID=MN8TOARS.
    10.1016/j.mito.2004.02.005
  54. Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Monteiro, P.; Gonçalves, L.; Providência, L.A.; Palmeira, C.M.; Moreno, A.J.M.. "Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function". Revista Portuguesa de Cardiologia 23 10 (2004): 1291-1298. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644236410&partnerID=MN8TOARS.
  55. Sardão, V.A.; Oliveira, P.J.; Moreno, A.J.M.. "Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: Relevance for caffeine toxicity". Toxicology and Applied Pharmacology 179 1 (2002): 50-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037082662&partnerID=MN8TOARS.
    10.1006/taap.2001.9334
  56. Oliveira, P.J.; Rolo, A.P.; Seiça, R.; Sardão, V.; Monteiro, P.; Gonçalves, L.; Providência, L.; et al. "Impact of diabetes on induction of the mitochondrial permeability transition.". Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 21 6 (2002): 759-766. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036616238&partnerID=MN8TOARS.
  57. Oliveira, P.J.; Rolo, A.P.; Sardão, V.A.; Coxito, P.M.; Palmeira, C.M.; Moreno, A.J.M.. "Carvedilol in heart mitochondria - Protonophore or opener of the mitochondrial KATP channels?". Life Sciences 69 2 (2001): 123-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035371154&partnerID=MN8TOARS.
    10.1016/S0024-3205(01)01109-2
Capítulo de livro
  1. Simões, Rui F.; Cunha-Oliveira, Teresa; Costa, Cláudio F.; Sardão, Vilma A.; Oliveira, Paulo J.. "In Vitro Methodologies to Investigate Drug-Induced Toxicities". In Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants, editado por Yvonne Will; James A. Dykens, 229-247. John Wiley & Sons, Inc., 2018.
    Publicado • 10.1002/9781119329725.ch14
  2. Vega-Naredo, I.; Cunha-Oliveira, T.; Serafim, T.L.; Sardao, V.A.; Oliveira, P.J.. "Analysis of pro-apoptotic protein trafficking to and from mitochondria". 2015.
    10.1007/978-1-4939-1875-1_14
  3. Deus, C.; Branco, A.F.; Oliveira, P.J.; Sardão, V.. "Caffeine Cardiovascular Toxicity: Too Much of a Good Thing". 2014.
    10.1016/B978-0-12-409517-5.00078-4
  4. Moreira, Ana C; Machado, Nuno G; Bernardo, Telma; Sardão, Vilma; Oliveira, Paulo J. "Mitochondria as a Biosensor for Drug-induced Toxicity – Is It Really Relevant?". In In Biosensors for Health, Environment and Biosecurity - Book 2, editado por Pier Andrea Serra. In Tech, 2011.
    Publicado
  5. Oliveira, P.J.; Sardão, V.A.; Wallace, K.B.. "Cardiovascular Toxicity of Mitochondrial Origin". 2008.
    10.1002/9780470372531.ch6
  6. Sardão, Vilma; Santos, Dario L.; Oliveira, P. J.. "Cardiac Mitochondrial Dysfunction Induced by Doxorubicin: Role of Calcium and Oxidative Stress.". In Mitochondrial Pharmacology and Toxicology, editado por Moreno, António J. M.; Oliveira, P. J.; Palmeira, Carlos M.. Research Signpost, 2006.
Poster em conferência
  1. Adriana Marques-Carvalho; Sara Canário; Sara Valente; Sardão, Vilma. "Mitochondria Performance During RANKL-induced Osteoclast Differentiation.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  2. Sara Canário; Adriana Marques-Carvalho; Sara Valente; Sardão, Vilma. "Role of Estrogen on Metabolic Remodeling during osteoclast differentiation.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  3. Sara Valente; Adriana Marques-Carvalho; Sara Canário; Sardão, Vilma. "How estrogen modulates mitochondrial function during osteoblast differentiation?". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  4. Margarida R. Silva; Ricardo J Marques; Barbara Sousa; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin effect in mitochondrial dynamics and biogenesis of breast cancer cells.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  5. Guida Bento; Sardão, Vilma; Maria Paula Macedo; Paulo J. Oliveira. "Metabolic fluxes of human urine-derived cells are comparable in young and old donors". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, 2019.
  6. Sara Valente; Sara Canário; Adriana Marques-Carvalho; Sardão, Vilma. "MitoBoneLomics: Estradiol remodeling effect on mitochondrial activity during osteoblast differentiation.". Trabalho apresentado em 46th European Calcified Tissue Society Congress, 2019.
  7. Bárbara Sousa; Joana Pereira; Ana Rita Nobre; Ricardo Marques; Patricia Carneiro; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin promotes anoikis resistance in breast cancer stem cells by stimulating the glycolytic behavior and lowering the oxidative stress". Trabalho apresentado em 7th I3S Scientific Retreat - IBMC/INEB/IPATIMUP, 2018.
  8. Carvalho, Adriana; Canário, Sara; Valente, Sara; Sardão, Vilma. "Mitochondria Performance During Osteoclast Differentiation – Exploring New Targets for Bone Disease Therapies.". Trabalho apresentado em 9th World Congress on Tergeting Mitochondria, Berlin, Germany,, 2018.
  9. Carvalho, Adriana; Sardão, Vilma. "Metabolic remodeling during RANKL-induced osteoclast differentiation.". Trabalho apresentado em MitoPorto – Mitochondrial evolution, metabolism and diseases, International symposium, University of Porto, Portugal,, 2018.
  10. Bento, Guida; Oliveira, Paulo; Macedo, Maria; Sardão, Vilma. "Human urine-derived cells from young and old donors for assessing glycolytic and oxidative phosphorylation functions.". Trabalho apresentado em MitoPorto – Mitochondrial evolution, metabolism and diseases, International symposium, University of Porto, Portugal,, 2018.
  11. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Sardão, Vilma; Soares, Pedro; Serafim, Teresa; Garrido, Jorge; Oliveira, Paulo; Borges, Fernanda. "In vitro characterization of potential biological applications of MITOK3, A NOVEL Mitocondriotropic Menadione derivative, EpiChemBio (CM1406) and MuTaLig (CA15135)". Trabalho apresentado em COST actions joint meeting 2017, Porto, Portugal,, 2017.
  12. Sardão, Vilma; Bento, Guida; Oliveira, Paulo. "Mitochondrial bioenergetic profile of human urine-derived stem cells.". Trabalho apresentado em MitoPorto – Advances in mitochondrial research, International symposium, University of Porto, Portugal, 2017.
  13. Teixeira, Jose; Amorim, Ricardo; Santos, Katia; Soares, Pedro; Sardão, Vilma; Serafim, Teresa; Garrido, Jorge; Borges, Fernanda; Oliveira, Paulo. "Improvement of menadione cytotoxic potential by a mitochondria-targeted strategy.". Trabalho apresentado em MitoPorto: Advances in Mitochondrial Research International Symposium, University of Porto, Portugal, 2017.
  14. Costa, Cláudio; Maleita, Joana; Deus, Cláudia M.; Pereira, Susana P; Serafim, Teresa; Sardão, Vilma; Oliveira, Paulo; Cunha-Oliveira, Teresa. "Characterization of mitochondrial parameters in cell lines in the presence or absence of glucose. Bioenergetic Analysis: establishment and characterization of new models.". Trabalho apresentado em MitoPorto - Advances in Mitochondrial Research, University of Porto, Portugal,, 2017.
  15. Serafim, Teresa; Pinho, Sónia; Martins, Tatiana R; Sardão, Vilma; Grilo, Luís F.; Cavallaro, Chiara H.; Yang, Shanshan; et al. "Impact of Maternal Obesity During Pregnancy on Fetal Hepatic Redox Profile and Quality Control Proteins.". Trabalho apresentado em MitoPorto - Advances in Mitochondrial Research, Porto, Portugal. University of Porto, Portugal, 2017.
  16. Serafim, Teresa; Deus, Cláudia M.; Cunha-Oliveira, Teresa; Sardão, Vilma; Cunha, Pedro; Veloso, Caroline; Costa, Daniela; et al. "Stimulation of mitochondrial metabolism in human breast cancer cells results in increased cell motility and decreased resistance to metabolic inhibitors.". Trabalho apresentado em MitoPorto - Advances in mitochondrial research, International Symposium, Porto, University of Porto, Portugal, 2017.
  17. Sardão, Vilma; Silva, Tiago B.; Simões, Rui; Oliveira, Paulo; Veloso, Caroline; Valente, Maria J.; Silva, Renata S.; Remião, Fernando; Borges, Fernanda. "Parkinson’s disease therapy with improved Catechol O-Methyltransferase (COMT) inhibitors display lower mitochondrial liabilities.". Trabalho apresentado em MitoPorto - Advances in mitochondrial research. International symposium, University of Porto, Portugal, 2017.
  18. Bento, Guida; Oliveira, Paulo; Sardão, Vilma. "A Protocol for Human Urine-derived Stem Cells Isolation, Expansion, and Mitochondrial Function Profile Analysis.". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genoa, Italy, 2017.
  19. Sardão, Vilma; Silva, Tiago B.,; Simões, Rui; Oliveira, Paulo; Vamente, Maria J.; Silva, Renata S.; Remião, Fernando; Borges, Fernanda. "Developing a Novel Generation of Catechol O-Methyltransferase (COMT) Inhibitors Without Mitochondrial Liabilities for the Therapy of Parkinson’s Disase". Trabalho apresentado em 7th World Congress on Tergeting Mitochondria, 2016.
  20. Silva, Ana M.; Sardão, Vilma. "Toxicity and Metabolic Evaluation of Estradiol, Coumestrol and Resveratrol on osteoblast-like MLO-A5 and osteocyte-like MLO-Y4 cell lines.". Trabalho apresentado em 4th Joint Meeting of ECTS and IBMS, 2015.
  21. Serafim, Teresa; Teresa Cunha-Oliveira; Sardão, Vilma; Deus, Cláudia M.; Greene, Amy; Perkins, Edward; Oliveira, Paulo. "Characterization of Mitochondria of Breast Cancer Cell Lines.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014.
  22. Couto, Renata; Sardão, Vilma. "Protective Effects of Phytoestrogens on Cardiac Lipotoxicity Induced by Palmitic Acid.". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical, 2014.
  23. Couto, Renata; Sardão, Vilma. "Protection provided by phytoestrogens on cardiac lipotoxicity induced by palmitic acid.". Trabalho apresentado em 48th Annual Meeting of the European Society for Clinical Investigation, in Utrecht, The Netherlands,, 2014.
  24. Sardão, Vilma; Silva, Ana Maria; Moreira, Ana C.; Santos, Maria S.; Videira, Romeu; Carvalho, Rui. "Lipidomics of mineral bone cells in normal and estrogen-deprived animals: Role of acute hormone-replacement therapeutics with estradiol and coumestrol". Trabalho apresentado em 5th International Symposium on Nutrition, Oxygen Biology & Medicine, in Paris, France, 2013.
  25. Silva, Ana Maria; Moreira, Ana C.; Santos, Maria Sancha; Videira, Romeu; Carvalho, Rui; Sardão, Vilma. "Understanding bone lipidomics of mineral bone cells in normal and estrogens-deprived animals". Trabalho apresentado em 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), Albufeira, Portugal, 2013.
  26. Moreira, Ana C.; Silva, Ana M.; Santos, Maria S.; Sardão, Vilma. "Resveratrol affects mitochondrial bioenergetics in brain and liver: a possible caution for its use against menopause symptoms". Trabalho apresentado em 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), Albufeira, Portugal, 2013.
  27. Branco, Ana F.; Sampaio, Susana F.; Sardão, Vilma; Gonzales, Susana; Oliveira, Paulo. "Isoproterenol-induced toxicity on H9c2 myoblasts depends on the differentiation status". Trabalho apresentado em 47th Annual Meeting of the European Society for Clinical Investigation, Albufeira, Portugal April 17-20, 2013, 2013.
  28. Serafim, Teresa; Sardão, Vilma; Greene, Amy; Perkins, Edward; Santos, Maria S.; Oliveira, Paulo. "Profilling mitochondrial physiology in commercial human cancer cell line for evaluating coumpound anticancer activity". Trabalho apresentado em 47th Annual Meeting of the European Society for Clinical Investigation, Albufeira, Portugal, 2013.
  29. Moreira, Ana C.; Wolf, Andrea; Soldner, Emma L. B.; Santos, Maria S.; Sardão, Vilma; Bauer, Björn; Hartz, Anika M. S.. "Modulation of GLUT-1 expression at the Blood-Brain Barrier by Estrogens". Trabalho apresentado em Beating the Blood-Brain and other Blood Barriers, Lisbon, Portugal, 2013.
  30. Sardão, Vilma. "Enterodiol Protects H9C2 Cardiomyoblasts From Palmitic Acid-Induced Lipotoxicity: Relevance for Hormone Replacement Therapy During Menopause". Trabalho apresentado em 3rd World Congress on Targeting Mitochondria, Berlin, German, 2012.
  31. Silva, Ana M.; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Gender-Dependent Rat Liver and Brain Mitochondrial Antioxidant Defenses". Trabalho apresentado em OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy, 2012.
  32. Sampaio, Susana; Moreira, Ana C.; Branco, Ana; Santos, Maria S.; Oliveira, Paulo; Sardão, Vilma. "Apoptosis-inducing Factor (AIF) Role in Anthracycline-Induced Cardiomyoblast Cell Death". Trabalho apresentado em OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy,, 2012.
  33. Moreira, Ana C.; Silva, Ana Maria; Santos, Maria S.; Sardão, Vilma. "Organ and gender-dependent mitochondrial antioxidante modulation by resveratrol,". Trabalho apresentado em OCC conferences: Oxidants and Antioxidants in Biology – Cell Signaling and Nutrient-Gene Interactions, Alba, Italy,, 2012.
  34. Moreira, Ana C.; Wolf, Andrea; Soldner, Emma L.B.; Santos, Maria S.; Sardão, Vilma; Hartz, Anika M. S.; Bauer, Björn. "Modulation of GLUT-1 Expression at Blood-Brain Barrier by Estrogens: a Mechanism to overcome Hot Flashes in Menopause". Trabalho apresentado em Gordon Research Conference, Barriers of CNS, New London, NH, USA, 2012.
  35. Sampaio, Susana; Moreira, Ana C.; Santos, Maria S.; Oliveira, Paulo; Sardão, Vilma. "Role of the Apoptosis-inducing Factor (AIF) on Doxorubicin-induced Cardiomyoblast Cell Death". Trabalho apresentado em 6th National Meeting on Cell Signaling, Braga, Portugal, 2012.
  36. Moreira, Ana C.; Silva, Ana M; Holy, Jon; Santos, Maria S.; Sardão, Vilma. "Differences in Breast Cell Proliferation and motility in the presence or absence of Estrogens and Phytoestrogens". Trabalho apresentado em 9th European Congress on Menopause and Andropause, Athens, Greece, 2012.
  37. Silva, Ana M.; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Resveratrol in Liver Mitochondria: Beyond its antioxidant role". Trabalho apresentado em 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary, 2012.
  38. Silva, Ana M.; Oliveira, Paulo; Moreira, Ana C.; Santos, Maria S.; Sardão, Vilma. "Are phytoestrogens able to prevent lipotoxicity in cardiac cells?". Trabalho apresentado em 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary, 2012.
  39. Moreira, Ana C.; Silva, Ana M.; Holy, Jon; Santos, Maria S.; Sardão, Vilma. "Effects of estrogens and phytoestrogens in breast cell proliferation and motility.". Trabalho apresentado em 46th Annual Scientific Meeting of the European Society for Clinical Investigation, Budapest, Hungary,, 2012.
  40. Serafim, Teresa; Sardão, Vilma; Greene, Amy; Perkins, Edward; Santos, Maria S.; Oliveira, Paulo. "Mitochondrial characterization of breast cancer cell lines for chemotherapeutic in vitro studies.". Trabalho apresentado em AACR Special Conference: Metabolism and Cancer, Baltimore, USA, 2011.
  41. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Toxicity and antioxidant capacity of resveratrol on liver and brain mitochondria – are there gender-dependent effects?". Trabalho apresentado em Mitochondrial Physiology and Medicine, Woods Hole, Massachusetts, USA,, 2011.
  42. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Are Phytoestrogens a Safe Alternative to Hormone Replacement Therapy? A toxicological study". Trabalho apresentado em 45th Annual Scientific Meeting of the European Society for Clinical Investigation, Crete, Greece, 2011.
  43. Silva, Ana M.; Moreira, Ana C.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Comparative liver mitochondria toxicity of phytoestrogens: effects as a matter of gender?". Trabalho apresentado em 17th National Congress of Biochemistry, Porto, Portugal, 2010.
  44. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Mitochondrial and Antioxidant Effects of Selected Phytoestrogens on Liver and Brain Fractions". Trabalho apresentado em 17th National Congress of Biochemistry, Porto, Portugal, December 15-17, 2010, 2010.
  45. Alves, Estela; Moreira, Ana C.; Silva, Ana M.; Santos, Maria S.; Sardão, Vilma. "Mitochondrial Safety of Phytoestrogens: Searching for an Alternative Hormone Replacement Therapy". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, 2010.
  46. Moreira, Ana C.; Silva, Ana M.; Alves, Estela; Santos, Maria S.; Sardão, Vilma. "Antioxidant Effects of Selected Phytoestrogens in Brain and Liver Mitochondria". Trabalho apresentado em SFRBM's 17th Annual Meeting, Orlando Florida, USA, 2010.
  47. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Cell motility is enhanced by autocrine factors in a murine model of breast cancer". Trabalho apresentado em AICR 30th Anniversary Conference: Today’s research – Tomorrow’s therapies, St Andrews, Fife, Scotland, 2010.
  48. Moreira, Ana C.; Branco, Ana F.; Oliveira, Paulo; Sardão, Vilma. "Caspase-independent apoptosis induced by Doxorubicin on Embryonic Ventricular H9c2 Myoblasts – Role of Apoptosis Inducing Factor (AIF) and Endonuclease G". Trabalho apresentado em 44th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, Italy, 2010.
  49. Gonçalves, Inês; Carneiro, D.; Lumini-Oliveira, José; Machado, Nuno; Marques, F.; Sardão, Vilma; Oliveira, Paulo; Magalhães, José; Ascensão, António. "Effects of acute endurance exercise on heart and liver mitochondrial function in rats treated with Doxorubicin". Trabalho apresentado em 3rd Meeting of Young Researchers of University of Porto, Porto, Portugal, 2010.
  50. Branco, Ana F.; Moreira, Ana C.; Pereira, Susana P; Sardão, Vilma; Oliveira, Paulo. "Toxicity of Isoproterenol Increases with the Differentiation State of H9c2 Myoblasts". Trabalho apresentado em 49th ASCB Annual Meeting, San Diego, CA, USA, 2009.
  51. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Regulation of cell motility in a novel murine breast cancer model system: Autocrine and mesenchymal stem cell effects". Trabalho apresentado em Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications, San Diego, California, USA, 2009.
  52. Ascensão, António; Lumini-Oliveira, José; Machado, Nuno; Gonçalves, Inês; Carneiro, Diogo; Marques, Franklim; Sardão, Vilma; Magalhães, José; Oliveira, Paulo. "Effects of Acute Endurance Exercise on Heart and Liver Mitochondrial Function in Rats Treated With Doxorubicin". Trabalho apresentado em 7th Annual Scientific Session, Society for Heart and Vascular Metabolism, Padova, Italy, 2009.
  53. Sardão, Vilma; Rose-Hellekant, Teresa; Perkins, Edward; Greene, Amy; Holy, Jon. "Cross-talk between mesenchymal stem cells and breast cancer cells – effects on cell motility". Trabalho apresentado em 18th Annual Short Course on Experimental Models of Human Cancer, The Jackson Laboratory, Highseas, Maine, USA, 2009.
  54. Braga, T. M.; Marques, J.; Paz, F. A. A.; Pillinger, M.; Branco. Ana F.; Sardão, Vilma; Diogo, Cátia V.; et al. "Nano-encapsulation of Antitumoral Metal Drug Candidates using Cyclodextrins". Trabalho apresentado em Nanomedicine 2009, 2nd European Summer School in Nanomedicine, Lisboa, Portugal, 2009.
  55. Branco, Ana F.; Moreira, Ana C.; Holy, Jon; Wallace, Kendall B.; Oliveira, Paulo; Sardão, Vilma. "Differential Sensitivity of Undifferentiated and Differentiated H9c2 Myoblasts to the Cardiotoxicant Doxorubicin". Trabalho apresentado em Molecular Regulation of Cardiac Disease Symposium, London, UK,, 2009.
  56. Serafim, Teresa; Sardão, Vilma; Matos, Júlio A.; Pereira, Gonçalo C.; Branco, Ana F.; Pereira, Sandro L.; Parke, Donna; et al. "Sanguinarine Inhibits the Proliferation of Metastatic Melanoma Cells by Nuclear and Mitochondrial Effects". Trabalho apresentado em Chemistry in Cancer Research: A Vital Partnership in Cancer Drug Discovery and Development, New Orleans, Louisiana, USA, 2009.
  57. Silva, Filomena S.G.; Sardão, Vilma; Oliveira, Paulo; Santos, Maria S.; Sousa, Maria do Céu; Santos-Silva, Alice; Pereira, Petronila Rocha. "Effects of 13-cis-RA and acitretin on tumor cell proliferation and isolated liver mitochondria". Trabalho apresentado em 16th National Congress of Biochemistry, Ponta Delgada, São Miguel, Açores, Portugal, 2008.
  58. Serafim, Teresa; Branco, Ana F.; Matos, Júlio A. C.; Sardão, Vilma; Pereira, Gonçalo C.; Parke, Donna; Perkins, Edward; et al. "Sanguinarine Cytotoxicity on Mouse Melanoma K1735-M2 Cells – Nuclear versus Mitochondrial Effects". Trabalho apresentado em 16th National Congress of Biochemistry, Ponta Delgada, São Miguel, Açores, Portugal, 2008.
  59. Silva, João P.; Sardão, Vilma; Proença, Fernanda; Coutinho, Olga P.; Oliveira, Paulo. "Nitrogen compounds as protectors of oxidative damage induced in H9c2 myoblasts". Trabalho apresentado em 16th Euroconference on Apoptosis & 5th Swiss Apoptosis Meeting, Bern, Switzerland,, 2008.
  60. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Doxorubicin Toxicity in H9c2 Embryonic Cardiomyoblasts: Morphological Alterations and Activation of p53-Bax Signaling Pathway". Trabalho apresentado em 6th Annual meeting of the Society for Heart and Vascular Metabolism, Boston, Massachusetts, USA, 2008.
  61. Branco, Ana F.; Sardão, Vilma; Pereira, Sandro L.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.; Oliveira, Paulo. "Differentiation of H9c2 embrionic ventricular cells results into increased susceptibility to the cardiac toxicants dosorubicin and isoproterenol". Trabalho apresentado em 6th Annual meeting of the Society for Heart and Vascular Metabolism, Boston, Massachusetts, USA, 2008.
  62. Pereira, Sandro L.; Sardão, Vilma; Branco, Ana F.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.; Oliveira, Paulo. "Toxicity of Doxorubicin and Isoproterenol Depends on the Differentiation Stage of H9c2 Myoblasts". Trabalho apresentado em Society of Toxicology Annual Meeting 2008, Seattle, WA, EUA, 2008.
  63. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Doxorubicin induces Apoptosis in H9c2 myoblasts – Contribution of P53/Bax pathways and oxidative stress". Trabalho apresentado em Apoptosis World 2008, From Mechanisms to Applications, Luxembourg, 2008.
  64. Branco, Ana F.; Pereira, Sandro L.; Sardão, Vilma; Wallace, Kendall B.; Oliveira, Paulo. "Apoptotic effect of isoproterenolon H9c2 myoblasts: Relevance of differentiation State". Trabalho apresentado em Apoptosis World 2008, From Mechanisms to Applications, Luxembourg,, 2008.
  65. Serafim, Teresa; Sardão, Vilma; Carvalho, Filipa S.; Marques, Maria P.; Garrido, Jorge; Milhazes, Nuno; Borges, Fernanda; et al. "Antiproliferative activity of ferulic and caffeic acid derivatives on tumor cell lines – Structure-function relations and direct effects on mitochondria". Trabalho apresentado em Apoptosis World 2008, From Mechanisms to Applications, Luxembourg, 2008.
  66. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Morphological Hallmarks of Doxorubicin Toxicity on H9c2 Myoblasts: The pro-oxidant action of the antineoplastic agent". Trabalho apresentado em European Meeting of the Society for Free Radical Research, Vilamoura, Portugal, 2007.
  67. Braga, Susana S.; Mokal, Vijaya; Paz, Filipe A. A.; Marques, Maria P. M.; Branco, Ana F.; Sardão, Vilma; Oliveira, Paulo; et al. "Cyclodextrin encapsulation of biomimetic organometallic cancer drud candidates". Trabalho apresentado em 6th International Medicinal Chemistry Symposium, Istanbul, Turkey, 2007.
  68. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "Morphologic Alterations Induced by the Antineoplastic Agent Doxorubicin in H9c2 myoblasts: Relevance for Doxorubicin Cardiotoxicity". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry – Anticancer Agents, Regua, Portugal, 2007.
  69. Serafim, Teresa; Sardão, Vilma; Holy, Jon; Marques, Maria P.; Batista de Carvalho, Luís A.E.; Garrido, Jorge; Milhazes, Nuno; et al. "Anti-proliferative profile of potential lipophilic antioxidants structurally based on the dietary antioxidants ferulic and caffeic acids". Trabalho apresentado em First Iberic Meeting on Medicinal Chemistry – Anticancer Agents, Regua, Portugal, 2007.
  70. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. "The H9c2 cell Line as a Model for Cardiotoxicology Studies – Imaging of Cell Dysfunction Induced By Tert-Butylhydroperoxide". Trabalho apresentado em XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  71. Pereira, Gonçalo C.; Serafim, Teresa; Sardão, Vilma; Teles, Ana I.; Moreno, António J. M.; Parke, Donna; Perkins, Edward; Holy, Jon; Oliveira, Paulo. "Berberine-induced Mitochondrial Depolarization and Fragmentation in K1735-M2 Rat Melanoma Cells – A Possible Mechanism for Berberine Anti-proliferative / Pro-apoptotic actions". Trabalho apresentado em XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  72. Matos, Júlio A.; Serafim, Teresa; Sardão, Vilma; Branco, Ana F.; Moreno, António J. M.; Parke, Donna; Perkins, Edward; Holy, Jon; Oliveira, Paulo. "Mitochondrial Involvement in Sanguinarine-Induced Apoptosis". Trabalho apresentado em XV National Congress of Biochemistry, Aveiro, Portugal, 2006.
  73. Marques, Maria P.; Amado, A.M.; Fiuza, S.M.; Oliveira, Paulo; Sardão, Vilma; Soares, Ana S; Urbano, Ana M.; Batista De Carvalho, L.A.E.. "Polynuclear Pt(II) and Pd(II) Polyamine Complexes as Novel Anticancer Agents,". Trabalho apresentado em XXXVII Meeting of Portuguese Society of Pharmacology, 2006, Porto, Portugal, 2006.
  74. Moreira, Ana C.; Branco, Ana F.; Holy, Jon; Oliveira, Paulo; Santos, Maria S.; Sardão, Vilma. "Role of the Apoptosis Inducing Factor and Endonuclease G in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 cells". Trabalho apresentado em 7th Annual meeting of the Society for Heart and Vascular Metabolism, Padova, Italy, 2006.
  75. Fiuza, Sónia; Amado, Ana M; Oliveira, Paulo; Sardão, Vilma; Marques, Maria P.; Batista de Carvalho, Luís A.E.. "Pt(II) and Pd(II) Complexes with Biogenic Amines - Structure-Activity Study". Trabalho apresentado em First European Conference on Chemistry for Life Sciences. Rimini, Italy, 2005.
  76. Fiuza, Sónia; Amado, Ana M.; Oliveira, Paulo; Sardão, Vilma; Marques, Maria P.; Batista de Carvalho, Luis A.E.. "Structure-Activity Study of Pt(II) and Pd(II) Spermidine Complexes". Trabalho apresentado em 12th International Conference on Biological Inorganic Chemistry - ICBIC12, Ann Arbor, Michigan, USA, 2005.
  77. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, Antonio J. M.. "Caffeine Induces Cytochrome c Release and Reduces Cardiac Mitochondrial ATP Production". Trabalho apresentado em XXIV Congresso Portugues de Cardiologia , Madeira (Portugal), 2003.
  78. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Moreno, António J. M.. "Toxicity of Caffeine in Heart Mitochondria: Enhancement of Permeability Transition and Disturbance of Mitochondrial Bioenergetic Processes". Trabalho apresentado em XIII Congresso Português de Bioquímica, Lisboa (Portugal), 2002.
  79. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Moreno, António J. M.. "Toxicity of Caffeine in Heart Mitochondria: Enhancement of Permeability Transition and Disturbance of Mitochondrial Bioenergetic Processes". Trabalho apresentado em European Bioenergetics Conference (EBEC), Arcachon, Bordeaux, France, 2002.
  80. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, António J. M.. "Mitocôndrias Cardíacas e Cafeína – Desregulação da Homeostase do Cálcio e Interacções com Cadeia Respiratória". Trabalho apresentado em XXIII Congresso Português de Cardiologia, Vilamoura, Portugal, 2002.
  81. Oliveira, Paulo; Rolo, Anabela P.; Coxito, Pedro; Santos, Dario L.; Sardão, Vilma; Seiça, Raquel; Monteiro, Pedro; et al. "Mitochondria From Diabetic Rats Cardiomyocytes are more resistent to the Induction of Permeability Transition Pore". Trabalho apresentado em 2nd European Meeting on Vascular Biology and Medicine, ULM, German, 2001.
  82. Sardão, Vilma; Oliveira, Paulo; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; Moreno, António J. M.. "Caffeine Induces Directly the Permeability Transition in Isolated Rat Heart Mitochondria". Trabalho apresentado em XXII Congresso Português de Cardiologia, Vilamoura, Portugal, 2001.
  83. Oliveira, Paulo; Rolo, Anabela P.; Seiça, Raquel; Sardão, Vilma; Monteiro, Pedro; Gonçalves, Lino; Providência, Luís A.; et al. "Heart Mitochondria From Diabetic Rats Are More Resistant to the Induction of the Mitochondrial Permeability Transition". Trabalho apresentado em XXII Congresso Português de Cardiologia, Vilamoura, Portugal, 2001.
  84. Oliveira, Paulo; Rolo, Anabela P.; Coxito, Pedro M.; Santos, Dario L.; Sardão, Vilma; Seiça, Raquel; Palmeira, Carlos M.; Santos, Maria S.; Moreno, António J. M.. "Decreased Susceptibility of Heart Mitochondria From Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium/Phosphate". Trabalho apresentado em II Congresso de Investigação em Medicina, Coimbra, Portugal, 2000.
  85. Paulo J. Oliveira; Pedro M. Coxito; Anabela P. Rolo; Sardão, Vilma; Carlos M. Palmeira; António J. M. Moreno. "Carvedilol in Heart Mitochondria: Protonophore or Opener of the Mitochondrial KATP Channels?". Trabalho apresentado em XII Congresso Português de Bioquímica, 2000.
  86. Oliveira, Paulo; Coxito, Pedro M.; Rolo, Anabela P.; Sardão, Vilma; Palmeira, Carlos M.; Moreno, Antonio J. M.. "Carvedilol in Heart Mitochondria: Protonophore or Opener of the Mitochondrial KATP Channels?". Trabalho apresentado em XII Congresso Português de Bioquímica, Póvoa do Varzim, Portugal., 2000.
Resumo em conferência
  1. Ana Maria Silva; Romeu A. Videira; Ana C. Moreira; Paulo J. Oliveira; Rui A. Carvalho; Sardão, Vilma. "Delving the Bone-buried Osteocytes lipid metabolism commitment in post-menopausal osteoporosis.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Publicado
  2. Guida Bento; Sardão, Vilma; Paula M. Macedo; Paulo J. Oliveira. "Metabolic fluxes of human urine-derived cells are comparable in young and old donors.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Publicado
  3. Margarida R. Silva; Ricardo Marques; Bárbara Sousa; Sardão, Vilma; Paulo J. Oliveira; Joana Paredes. "P-cadherin effect in mitochondrial dynamics and biogenesis of breast cancer cells.". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
  4. Canário, Sara; Carvalho, Adriana; Valente, Sara; Sardão, Vilma. "Role of estrogen on metabolic remodeling during osteoclast differentiation". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Publicado
  5. Carvalho, Adriana; Canário, Sara; Valente, Sara; Sardão, Vilma. "Mitochondria performance during rankl-induced osteoclast differentiation". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Publicado
  6. Valente, Sara; Marques-Carvalho, Adriana; Canário, Sara; Sardão, Vilma. "How estrogen modulates mitochondrial function during osteoblast differentiation?". Trabalho apresentado em 53rd Annual Meeting of the European Society for Clinical Investigation, Coimbra, 2019.
    Publicado
  7. Guida Bento; Paulo J. Oliveira; Paula M. Macedo; Sardão, Vilma. "Human urine-derived cells for assessing metabolic profile and mitochondrial morphology in young and old donors". Trabalho apresentado em 52nd Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2018.
    Publicado
  8. Vecchione, G.; Grasselli, E.; Oliveira, P. J.; Sardao, V. A.; Cioffi, F.; Baldini, F.; Cortese, K.; et al. "Silybin-vitamin E phytosome complex counteracts lipid excess and oxidative stress in an in vitro model of non alcoholic steatohepatitis (NASH)". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
  9. Bento, G.; Oliveira, P. J.; Sardao, V. A.. "A protocol for human urine-derived stem cells isolation, expansion, and mitochondrial function profile analysis". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Aceite para publicação
  10. Grasselli, E.; Demori, I.; Vecchione, G.; Oliveira, P. J.; Sardao, V. A.; Baldini, F.; Voci, A.; Portincasa, P.; Vergani, L.. "A novel cellular model to study the combined actions of fructose and fatty acids in inducing a steatohepatitis condition". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
  11. Serafim, T. L.; Cunha-Oliveira, T.; Sardao, V. A.; Deus, C. M.; Cardoso, I.; Pinho, S.; Yang, S.; et al. "Maternal obesity (MO) in sheep decreases fetal hepatic mitochondrial respiratory chain activity and total mitochondrial lipids". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Publicado
  12. Wojtala, A.; Lebiedzinska-Arciszewska, M.; Jezdrak, P.; Sardao, V. A.; Wegrzyn, G.; Pronicki, M.; Pinton, P.; et al. "Characterisation of the mitochondrial bioenergetic, ROS and status of antioxidant defence system profiles in fibroblasts of patients showing mitochondrial abnormalities". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Publicado
  13. Teixeira, J. C.; Amorim, R.; Santos, K.; Soares, P.; Serafim, T.; Sardao, V.; Garrido, J.; Borges, F.; Oliveira, P.. "MitoK3, a novel mitochondriotropic menadione derivative with cytotoxic effects on cancer cells". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Publicado
  14. Sardao, V. A.; Silva, T. B.; Simoes, R. F.; Oliveira, P. J.; Veloso, C. D.; Valente, M. J.; Silva, R. S.; Remiao, F.; Borges, F.. "Promising new catechol O-methyltransferase (COMT) inhibitors for Parkinson's disease display lower mitochondrial toxicity". Trabalho apresentado em 51th Annual Meeting of the European Society for Clinical Investigation, Genova, 2017.
    Publicado
  15. Silva, T.; Simoes, R. F.; Sardao, V.; Oliveira, P. J.; Valente, M. J.; Silva, R.; Remiao, F.; Borges, F.. "In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols". 2016.
    10.1016/j.toxlet.2016.06.1517
  16. Sardão, Vilma; Paulo J. Oliveira; Pedro Monteiro; Lino Gonçalves; Luís Providência; António J. M. Moreno. "A Cafeína Induz Directamente a Transição de Permeabilidade em Mitocôndrias Isoladas de Coração de Rato". Trabalho apresentado em XXII Congresso Português de Cardiologia, Vilamoura, 2001.
    Publicado
Tese / Dissertação
  1. Oliveira, Vilma Marisa Arrojado Soares Sardão. "H9C2 myoblasts as a tool to study doxorubicin-induced cardiomyopathy : mechanisms of cell death and relevanceof cell differentiation". Doutoramento, 2008. http://hdl.handle.net/10316/9633.
  2. Sardão, Vilma. "A Toxicidade da Cafeína ao Nível da Função Mitocondrial Cardíaca: Desregulação da Homeostase do Cálcio e Interacções com a Cadeia Respiratória". Licenciatura, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2002.

Outros

Outra produção
  1. Role of mtDNA-related mitoepigenetic phenomena in cancer. Abnormal mitochondrial function has long been associated with the development and the progression of cancer. Multiple defects in the mitochondrial genome have been reported for various cancers, however the often disregarded mitochondrial epigenetic landscape provides an additional source of deregulation that may contribute to carcinogenesis.. 2015. Ferreira, André; Serafim, Teresa L; Sardão, Vilma A; Cunha-Oliveira, Teresa. http://hdl.handle.net/10316/41108.
  2. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Mitochondria play a key role in cell death and its regulation. The permeabilization of the outer mitochondrial membrane which is mainly controlled by proteins of the BCL-2 family, is a key event that can be directly induced by p53 and results in the release of pro-apoptotic factors to the cytosol, such as cytochrome c, second mitochondria derived activator of caspases/direct inhibitor-of-apoptosis. 2015. Vega-Naredo, Ignacio; Cunha-Oliveira, Teresa; Serafim, Teresa L; Sardao, Vilma A; Oliveira, Paulo J. http://hdl.handle.net/10316/41110.
  3. Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts. The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative stress, disruption of calcium homeostasis and activation of cardiomyocyte death. Nevertheless, antioxidants and caspase inhibitors often show little efficacy in preventing cell death. We hypothesize that a caspase-independent cell death mechanism with the release of the apoptosis-inducing factor from mitochondri. 2014. Moreira, Ana C; Branco, Ana F; Sampaio, Susana F; Cunha-Oliveira, Teresa; Martins, Tatiana R; Holy, Jon; Oliveira, Paulo J; Sardão, Vilma A. http://hdl.handle.net/10316/41109.
  4. ß-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?. Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to. 2014. Branco, Ana F; Moreira, Ana C; Cunha-Oliveira, Teresa; Couto, Renata; Sardao, Vilma A; Rizvanov, Albert A; Palotas, Andras; Oliveira, Paulo J. http://hdl.handle.net/10316/44868.
  5. Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds. The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle. 2014. Braga, Susana S.; Mokal, Vijaya; Almeida Paz, Filipe A.; Pillinger, Martyn; Branco, Ana F.; Sardao, Vilma A.; Diogo, Catia V.; et al. http://hdl.handle.net/10773/19837.
    10.1002/ejic.201402540
  6. Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of gender. Resveratrol (3,5,40-trihydroxy-trans stilbene) is commonly recognized by its antioxidant properties. Despite its beneficial qualities, the toxic effects of this natural compound are still unknown. Since mitochondria are essential to support the energy-dependent regulation of several cell functions, the objective of this study was to evaluate resveratrol effects on rat brain and liver mitochondrial. 2013. Moreira, Ana C.; Silva, Ana M.; Santos, M. S.; Sardão, Vilma A.. http://hdl.handle.net/10316/25782.
  7. Mitochondrial disruption occurs downstream from ß-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: Differential activation of stress and survival pathways. ß-Adrenergic receptor stimulation plays an important role in cardiomyocyte stress responses, which may result in apoptosis and cardiovascular degeneration. We previously demonstrated that toxicity of the ß-adrenergic agonist isoproterenol on H9c2 cardiomyoblasts depends on the stage of cell differentiation. We now investigate ß-adrenergic receptor downstream signaling pathways and stress responses. 2013. Branco, Ana F.; Sampaio, Susana F.; Wieckowski, Mariusz R.; Sardão, Vilma A.; Oliveira, Paulo J.. http://hdl.handle.net/10316/26910.
  8. Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?. Mitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how mitochondrial oxidative phosphorylation produces energy, mitochondrial research was not a priority for most cell biologists until novel mitochondrial functions were identified. In fact, it is now known that mitochondria are not only involved in cell ca. 2009. Pereira, Cláudia V; Moreira, Ana C; Pereira, Susana P; Machado, Nuno G; Carvalho, Filipa S; Sardão, Vilma A; Oliveira, Paulo J. http://hdl.handle.net/10316/47550.
  9. Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Abstract Doxorubicin (Dox) is a very potent antineoplastic agent used against several types of cancer, despite a cumulative cardiomyopathy that reduces the therapeutic index for treatment. H9c2 myoblast cells have been used as an in vitro model to study biochemical alterations induced by Dox treatment on cardiomyocyte cells. Despite the extensive work already published, few data are available rega. 2008. Sardão, Vilma; Oliveira, Paulo; Holy, Jon; Oliveira, Catarina; Wallace, Kendall. http://hdl.handle.net/10316/7866.
  10. Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. Abstract Purpose Natural products represent a rich reservoir of potential small molecule inhibitors exhibiting antiproliferative and tumoricidal properties. An example is the isoquinoline alkaloid berberine, which is found in plants such as goldenseal (Hydrastis canadensis). Studies have shown that berberine is able to trigger apoptosis in different malignant cell lines, and can also lead to cell. 2008. Serafim, Teresa; Oliveira, Paulo; Sardao, Vilma; Perkins, Ed; Parke, Donna; Holy, Jon. http://hdl.handle.net/10316/7874.
  11. Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--Nuclear vs. mitochondrial effects. http://www.sciencedirect.com/science/article/B6T4P-4T193YB-5/2/8b89adb1a424a742b294db27ed9982c6. 2008. Serafim, Teresa L.; Matos, Júlio A.C.; Sardão, Vilma A.; Pereira, Gonçalo C.; Branco, Ana F.; Pereira, Sandro L.; Parke, Donna; et al. http://hdl.handle.net/10316/10082.
  12. Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death. Background When exposed to oxidative conditions, cells suffer not only biochemical alterations, but also morphologic changes. Oxidative stress is a condition induced by some pro-oxidant compounds, such as by tert-butylhydroperoxide (tBHP) and can also be induced in vivo by ischemia/reperfusion conditions, which is very common in cardiac tissue. The cell line H9c2 has been used as an in vitro cellu. 2007. Sardão, Vilma A.; Oliveira, Paulo J.; Holy, Jon; Oliveira, Catarina R.; Wallace, Kendall B.. http://hdl.handle.net/10316/12646.
  13. Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium] is an alkaloid present in plant extracts and has a history of use in traditional Chinese and Native American medicine. Because of its ability to arrest the cell cycle and cause apoptosis of several malignant cell lines, it has received attention as a potential anticancer therapeutic agent. Previo. 2007. Pereira, Gonçalo C.; Branco, Ana F.; Matos, Júlio A. C.; Pereira, Sandro L.; Parke, Donna; Perkins, Edward L.; Serafim, Teresa L.; et al. http://hdl.handle.net/10316/12625.
  14. Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study. 2006. Fiuza, S.; Amado, A.; Oliveira, Paulo; Sardao, Vilma; de Carvalho, L.; Marques, M.. http://hdl.handle.net/10316/45139.
  15. Bile acids are toxic for isolated cardiac mitochondria. Abstract Cholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that bile acids are toxic to heart mitochondria for concentrations that are relevant for cholestasis. Heart mitochondria were isolate. 2005. Ferreira, Manuela; Coxito, Pedro; Sardão, Vilma; Palmeira, Carlos; Oliveira, Paulo. http://hdl.handle.net/10316/7824.
  16. Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats. The heart is one of the organs affected during the later stages of diabetes. Mitochondrial function has already been proposed to be affected during the course of diabetes. Nevertheless, little information is known concerning the impact of antioxidants in heart mitochondria of a milder model for diabetes, such as the Goto-Kakizaki (GK) rat, where mitochondrial function appears ameliorated. The obje. 2004. Oliveira, Paulo J.; Seica, Raquel; Santos, Dario L.; Rolo, Anabela P.; Sardao, Vilma A.; Ferreira, Fernanda M. L.; Palmeira, Carlos M.; Santos, Maria S.; Moreno, António J. M.. http://hdl.handle.net/10316/5391.
  17. Caffeine Enhances the Calcium-Dependent Cardiac Mitochondrial Permeability Transition: Relevance for Caffeine Toxicity. Caffeine (1,3,7-trimethylxanthine), a compound present in beverages such as tea and coffee, is known to be toxic at high concentrations. Some of the observed clinical conditions include cardiovascular disease and reproductive disorders, among others. The possible toxic effects of caffeine on heart mitochondria are still poorly understood. The influence of caffeine on the mitochondrial permeability. 2002. Sardão, Vilma A.; Oliveira, Paulo J.; Moreno, António J. M.. http://hdl.handle.net/10316/5419.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/04/11 Real-Time Cell Metabolic Analysis Using the Seahorse XF Analyzers – Technical Considerations Invited lecture within the scope of the Ph.D. Program in Experimental Biology and Biomedicine
University of Coimbra, Institute of Interdisciplinary Research (Cantanhede, Portugal)
2023/03/20 2D and 3D in vitro cell modes used in cancer research Invited lecture within the scope of the Masters Program in Molecular and Celular Biology - Cancer molecular Biology
University of Coimbra, Faculty of Sciences and Technology, Life Sciences Department (Coimbra, Portugal)
2023/03/08 The Role of the P53 Protein in cancer development Invited lecture within the scope of the Masters Program in Molecular and Celular Biology - Cancer molecular Biology
University of Coimbra, Faculty of Sciences and Technology, Life Sciences Department (Coimbra, Portugal)
2021/12/02 Basic Concepts in Cellular Metabolism
Pharmacy Student Center, Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2021/10/28 Mitochondrial Profiles of Lynphoblasts Obtained from ALS Patients with or without Known SOD1 mutations 12th World Congress on Targeting Mitochondria
World Mitochondria Society
2021/06/18 Exercise, Metabolism, and Mitochondria Seminário e Ciclo de Palestras CIDAF
Universidade de Coimbra, Faculdade de Ciências do Desporto e Educação Fisica (Online event, Portugal)
2021/06/12 MitoBone: Mitochondrial fitness in bone metabolism 55th Annual Scientific Meeting of European Society for Clinical Investigation
European Society for Clinical Investigation
2021/06/11 Estrogens inhibit RANKL-induced complex I activity and metabolic remodeling during the early stages of osteoclast differentiation 55TH ANNUAL SCIENTIFIC MEETING – Online Event
European Society for Clinical Investigation (Online event)
2021/06/11 Multi-dimensional Analysis of Metabolic and Mitochondrial Dysfunction Parameters in Lymphoblasts from Amyotrophic Lateral Sclerosis Patients 55th Annual Scientific Meeting of European Society for Clinical Investigation, online version
European Society for Clinical Investigation (Online event)
2021/01/20 Introduction to cell culture: fundamental principles, methods, and troubleshooting Fundamentals of Cellular and Molecular Metabolism:Relevance for Health and Disease
ITMO University, Saint Petersburg, Russia / Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2021/01/20 Methodologies for assessing mitochondrial respiration, Fundamentals of Cellular and Molecular Metabolism:Relevance for Health and Disease
ITMO University, Saint Petersburg, Russia / Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2020/11/20 Epidemiology of Physical Activity and Public Health - A Biochemical perspective on benefits of exercise Invited lecture within the scope of the PhD program in Sport Science,
Faculty of Sport Sciences and Physical Education, University of Coimbra (Coimbra, Portugal)
2020/09 Biological activity of brassica by-products in cell models of lipid toxicity European Journal of Clinical Investigation Virtual Meeting 2020
European Journal of Clinical Investigation
2020/09 Exploratory data analysis applied to metabolic profiling of urine-derived stem cells from young and elderly women. Annual Meeting of the European Society for Clinical Investigation, Virtual Meeting,
European Society for Clinical Investigation
2020/09 Estrogens inhibit RANKL-induced early stimulation of complex I and mitochondria function in osteoclast progenitors. Annual Meeting of the European Society for Clinical Investigation, Virtual Meeting
Annual Meeting of the European Society for Clinical Investigation
2020/07/17 Mitochondrial metabolism and sports science Lecture within the scope of the PhD program in Sport Science
Universidade de Coimbra, Faculdade de Ciências do Desporto e Educação Fisica (Coimbra, Portugal)
2019/07/10 Role of Mitochondria in bone homeostasis MiP/MitoEAGLE Training School Coimbra
University of Coimbra (Coimbra, Portugal)
2019/07/01 Methodologies for measuring mitochondrial respiration School 3 “Novel technological developments for metabolic studies”
H2020-MSCA-ITN TREATMENT GA721236, University of Coimbra (Coimbra)
2019/05/23 Delving the Bone-buried Osteocytes lipid metabolism commitment in post-menopausal osteoporosis. 53rd Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
2019/01/18 From gene to protein – Evaluating the effects of environmental pollutants on biological systems Invited lecture within the scope of the Master program Ecology
, Faculty of Sciences and Technology, Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2017/10/19 Osteoporose: a perda silenciaosa Conferências no Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (Mamarosa-Aveiro, Portugal)
2017/03/07 Menopause, Ostoporosis and NAFLD, CNBC/PDBEB Advanced Course: Metabolism and Disease: Causes and Consequences of Non-Alcoholic Fatty Liver Disease (NAFLD)
Center for Neuroscience and Cell Biology (Coimbra , Portugal)
2017/03/07 Viver a Menpausa sem Tabus Conferências no Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (IEC) (Mamarosa-Aveiro, Portugal)
2016/12/19 Overcoming menopause effects: What can we do for it CNBC annual meeting
Center for Neuroscience and Cell Biology (CNBC) (Coimbra, Portugal)
2016/11/18 Meta”bone”lomics of post-menopausal osteoporosis CNBC Seminars
Center for Neuroscience and Cell Biology (CNBC) (Coimbra, Portugal)
2016/10/12 Osteoporose: Mecanismos, diagnóstico e formas de tratamento Jornadas de Biologia
niversity of Trás-os-Montes e Alto Douro (Vila-Real, Portugal)
2016/05/07 As maleitas da Menopausa Conversa Não Programada
Exploratório de Coimbra - Centro Ciência Viva (Coimbra, Portugal)
2015/04/25 Estradiol modulates and recovers osteocyte metabolic/lipid profiles after ovariectomy in acute and long-term in vivo hormone replacement therapeutics. 4th Joint Meeting of ECTS and IBMS
ECTS and IBMS (Rotterdam, Países Baixos)
2014/12/17 24h hormone replacement therapy induced relevant osteocyte metabolic remodeling in a post-menopausal osteoporosis rat model. XVIII Congress of Portuguese Society of Biochemistry
Portuguese Society of Biochemistry (Coimbra, Portugal)
2014/11/21 Analysis of Cell Metabolism using the Seahorse Extracellular Flux Analyser – Technical Considerations Integrating Metabolimics and Cell Physiology Workshop
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2014/04/30 Involvement of Mitochondrial Apoptosis-inducing Factor I Doxorubicin-induced Cardiotoxicity 48th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Utrech, Países Baixos)
2013/07/10 Phytoestrogens against menopausal symptoms: fighting woman nature
Department of Biology, University of Braga (Coimbra, Portugal)
2013/04/29 Phytoestrogens as alternative during hormone replacement therapy – The heroes, the villains or the useless? Natural Products: Health and Pharmaceutical Research Workshop
Escola Superior Agrária de Coimbra (Coimbra, Portugal)
2013/04/20 The increased risk of cardiovascular diseases after menopause: Young women start protecting your heart! 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/04/18 Sex Hormones and Cardiovascular Performance 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical investigation (ESCI) (Albufeira, Portugal)
2013/04/17 Phytoestrogens as Potential Alternative for Hormone Replacement Therapy 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal)
2013/04/17 Post-menopausal bone loss: comparison of the metabolic profiles of bone-embedded osteocytes in normal and ovariectomized female rats 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal)
2012/06/17 Modulation of GLUT-1 expression by estrogens at the Blood Brain Barrier: a model to overcome hot flushes in menopause? Gordon Research Seminar – Barriers of CNS
(New London, New Hampshire, Estados Unidos)
2011/02/02 Estrogen-Dependent Effects on Breast Cancer Cell Motility and proliferation XLI Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2010/04/30 Measuring in vitro tumor cell migration/invasion using 2D and 3D models – Applications in toxicology and drug discovery XI Jornadas de Biologia Aplicada
University of Braga (Braga, Portugal)
2009/12/02 Caspase-Independent Mechanisms in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 cells XXXL Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2007/12/05 Mechanisms of doxorubicin-Induced H9c2 myoblast death – Involvement of p53/Bax pathways and oxidative stress XXXVIII Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2006/12/05 The H9c2 Cell Line as a Model For Drug-Induced Alterations on Cardiac Cells: Morphologic Alterations Induced by Doxorubicin Exposure XXXVII Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto)
2006/09/06 Morphological Endpoints of Cell Death Upon Exposure of H9c2 Embryonic Ventricular Cells to tert-butylhydroperoxide 4th Annual meeting of the Society for Heart and Vascular Metabolism
(Semiahmoo, WA, Estados Unidos)
2005/12/13 Adriamycin-induced cardiomyopathies: role and mechanisms of mitochondrial dependent and independent cell death Research Seminars for 2005-2006,
University of Minnesota, Medical School – Duluth Campus (Duluth, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/10/01 - Atual Effect of lifelong exercise in the immune system and in the prevention of colon cancer: role of mitochondria
Coorientador de Ana Rita Vieira Pedrosa
 Doctorate Program in Sport Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2019 - 2023/06/13 mitoBone: Mitochondrial performance on osteoclast differentiation and function during E2 deprivation - Finding new targets for osteoporosis treatment
Orientador de Adriana Marques Carvalho
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - 2020 Biological activity of Brassica by-products in cell models of lipid toxicity
Orientador de José Pedro Fernandes Castelão Moreira Baptista
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2020 Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation: Developing new approaches for osteoporosis treatment
Orientador de Sara Inês Furtado Canário
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2020 Menopause vs. Osteoporosis – The role of phytoestrogens on bone remodeling and their antiosteoporetic effects
Orientador de Ana Maria Pereira da Silva
 Doutoramento em Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Mitochondrial Performance During Osteoblast Differentiation - Searching New Targets to Counteract Osteoporosis
Orientador de Sara Cristiana Alves Valente
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2017 Analysis of mitochondrial respiratory chain proteins and sirtuin 3 in brain homogenates from ovariectomized rats in the presence and absence of estradiol and the phytoestrogen coumestrol, by the western blot method.
Orientador de Joana Faria
 Biologia Humana (Licenciatura/Bacharelato)
Universidade de Évora, Portugal
2016 - 2017 Células estaminais derivadas da urina: Análise metabólica e tentativa de optimização do processo de crescimento celular
Orientador de José Pedro Fernandes Castelão Moreira Baptista
 Bioquímica (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2014 Protection Provided by Phytoestrogens against Cardiac Lipotoxicity Induced by Palmitic Acid
Orientador de Renata Lopes Familiar Couro
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2014 Prevention of Cardiac Lipotoxicity Induced by Palmitic Acid by the phytoestrogen Coumestrol
Orientador de Francisca Goulão Mora
 Bioquímica (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09/01 - 2013/12 Phytoestrogens as Alternative to the Hormone Replacement Therapy: Cellular and Mitochondrial Interactions
Coorientador de Ana Carolina dos Santos Moreira
 Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09 - 2010/06 Avaliação Toxicológica de Fitoestrogénios em mitocôndrias cardíacas
Coorientador de Estela Filipa dos Santos Alves
 Bioquímica
Universidade de Évora Escola de Ciências e Tecnologia, Portugal
2008 - 2009 Caspase-Independent Mechanism in the Cytotoxicity of Doxorubicin on Embryonic Ventricular H9c2 Cells
Coorientador de Ana Carolina dos Santos Moreira
 Biologia (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/06/09 - 2021/06/11 Symposium Mitochondria in Health and Disease, in the 55th Annual Scientific Meeting of the European Society for Clinical Investigation, Online Event (2021/06/10 - 2021/06/11)
Simpósio (Coorganizador)
 European Society for Clinical Investigation, Países Baixos
2021/06/09 - 2021/06/09 Pre-meeting Course in the 55th Annual Scientific Meeting of European Society for Clinical Investigation on Cell respirometry. (2021/06/09 - 2021/06/09)
Oficina (workshop) (Presidente da Comissão Organizadora)
 European Society for Clinical Investigation, Países Baixos
2019/09/01 - 2019/09/06 Second edition of FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, (2019/09/01 - 2019/09/06)
Congresso
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Federation of European Biochemical Societies, Reino Unido
2018/11/01 - 2019/05/24 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI2019) (2019/05/22 - 2019/05/24)
Congresso (Membro da Comissão Organizadora)
 European Society for Clinical Investigation , Países Baixos
2019/02/01 - 2019/05/22 Mitochondrial and Cellular Respirometry - Pre-congress course in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019/05/22 - 2019/05/22)
Oficina (workshop) (Coorganizador)
 European Society for Clinical Investigation , Países Baixos
2017/06/18 - 2017/06/24 FEBS Advanced Lecture Course on Oncometabolism – From Conceptual Knoeledge to Clinical Applications, in Figueira da Foz, Portugal (2017/06/18 - 2017/06/24)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Federation of European Biochemical Societies, Reino Unido
2016/04/11 - 2016/04/15 Cell Respirometry: Basics and Applications (2016/04/11 - 2016/04/15)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/02/02 - 2015/02/03 Cancer Epigenetics and Metabolism: Connecting the Dots (2015/02/02 - 2015/02/03)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/12/17 - 2014/12/20 XVIII Congress of the Portuguese Biochemical Society (SPB) (2014/12/17 - 2014/12/20)
Congresso (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Bioquímica, Portugal
2013/04/17 - 2013/04/20 Symposium in the 47th Annual Meeting of the European Society for Clinical Investigation (ESCI), in Albufeira, Portugal. Workshop title: “Pathophysiology of menopause: more than just aging?” (2013/04/17 - 2013/04/20)
Simpósio (Membro da Comissão Organizadora)
 European Society for Clinical Investigation, Países Baixos
2010/05/11 - 2010/05/14 Survival or Death as a Matter of Fat, International Courses on Toxicology (2010/05/11 - 2010/05/14)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/05/05 - 2009/05/09 Mitochondria: Between Life and Death (International Courses on Toxicology) (2009/05/05 - 2009/05/09)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/04/09 - 2008/04/11 Metabolic Toxicology, From Pathway to Organism (International Courses on Toxicology) (2008/04/09 - 2008/04/11)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/03/22 - 2006/03/24 Smart Toxicology: Subcellular Targets of Anti-cancer Therapy (International Courses on Toxicology) (2006/03/22 - 2006/03/24)
Congresso (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/09/24 - 2020/09/24 Introduction to Data Management Plans - online course
Oficina (workshop)
 Introduction to Data Management Plans
BioData.pt, Portugal
2015/02/15 - 2015/03/20 Participant in the entrepreneurship Courses "ineoStart Business Acceleration Programme"
Concurso
 ineoStart Business Acceleration Programme
Universidade de Coimbra - Instituto Pedro Nunes, Portugal
2010/04/19 - 2010/04/30 Participant in the course "Introduction to Laboratory Animal Science - FELASA Cat C"
Outro
 Introduction Laboratory Animal Science - FELASA Cat C
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/10/26 - 2009/10/28 Participant in the course "The second genome: mitochondrial genetics – fromgenotype to phenotype and clinical expression"
Outro
 The second genome: mitochondrial genetics – fromgenotype to phenotype and clinical expression
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/08/21 - 2009/08/30 Participant in the "18th Annual Short Course on Experimental Models of Human Cancer"
Outro
 18th Annual Short Course on Experimental Models of Human Cancer
Howard Hughes Medical Institute - The Jackson Laboratory, Estados Unidos
2005/04/27 - 2005/04/29 Participant in the course "Mitochondria: Between Life and Death"
Outro
 Mitochondria: Between Life and Death
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/01/12 - 2003/01/16 Participant in the course "Biology of cell death II: Apoptosis Regulation"
Outro
 Biology of cell death II: Apoptosis Regulation
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002/10/08 - 2002/10/11 Participant in the short Course "Competence management and Personal Valorization", organized by School of Science and Technology of University of Coimbra
Outro
 Competence management and Personal Valorization
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002/10/04 - 2002/10/06 Participant in the "Bioenergetics: The Cellular Power Plants", the 4th Short Course organized by the of Portuguese Biophysical Society
Outro
 Bioenergetics: The Cellular Power Plants
Sociedade Portuguesa de Bioquímica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/06/13 MitoBone: Mitochondrial performance on osteoclast differentiation and function during E2 deprivation - Finding new targets for osteoporosis treatment
Orientador
 Adriana Marques Carvalho (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/12/21 Chronic inflammatory cartilage biomarkers in athletes from different sports. Interpreting acute and chronic response to exercise from several inflammatory biomarkers: a review; Correlation between chronic inflammatory biomarkers in male athletes from ultra-running, rugby and cross-training.
Arguente principal
 Pedro Afonso da Silva Valente (Mestrado)
Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2020/12/04 Biological activity of Brassica by-products in cell models of oxidative stress and lipid toxicity
Orientador
 José Pedro Fernandes Castelão Moreira Baptista (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2020/02/27 Orchestrating Osteoclast Differentiation Through ROS and Mitochondrial Regulation: Developing new approaches for osteoporosis treatment
Orientador
 Sara Inês Furtado Canário (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/10 Mitochondrial Performance During Osteoblast Differentiation – Searching New Targets to Counteract Osteoporosis
Orientador
 Sara Cristina Valente Dos Santos (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/13 The importance of cytokines-mediated communication in CSCs’ formation
Arguente principal
 Marco Rafael Lopes da Cunha (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/09 Tracking of the intracellular cytokines’transduced signals
Arguente
 Eurico da Silva Serrano (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models
Arguente principal
 Ana Filipa Fernandes Ferreira Sobral (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Desenvolvimento de uma nova estratégia terapêutica para cancro da mama, envolvendo a acção combinada de terapia génica e quimioterapia.
Arguente principal
 Gabriela de Jesus Leão Pereira dos Santos (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Bacterial protein azurin as a new candidate anticancer drug by decreasing cell adhesion through integrins
Arguente principal
 Sofia de Almeida Santos de Castro e Abreu (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Phytoestrogens as Alternative to the Hormone Replacement Therapy: Mitochondrial and Cellular Interactions
Orientador
 Ana Carolina dos Santos Moreira (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/11/26 Análise proteómica das fracções subcelulares de uma linha cellular de neuroblastomas humanos.
Arguente principal
 Stella Tatiana Liahuca de Esteves (Mestrado)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/01/12 - Atual Journal of Visualized Experiments (1940-087X) MyJoVE Corporation
2019/09 - Atual Toxicology in Vitro (0887-2333) Elsevier
2019/09 - Atual Mitochondrion (1567-7249) Elsevier
2019/07/28 - Atual Journal of Endocrinology (1479-6805) Bioscientifica
2019/05/31 - Atual Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2019/02 - Atual Molecules (1420-3049) MDPI AG
2018/09 - Atual Nutrients (2072-6643) MDPI AG
2018/06 - Atual PeerJ (2167-8359) PeerJ
2018/06 - Atual Biochemical Pharmacology (0006-2952) Elsevier
2018/03/01 - Atual Journal of Functional Foods (1756-4646) Elsevier
2017/12 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2017/11 - Atual Life Sciences (0024-3205) Elsevier
2017/09/26 - Atual Biology of Sex Differences (2042-6410) Springer (Biomed Central Ltd.)
2017/09/04 - Atual International Journal of Reproductive Medicine & Gynecology (2314-5757) Hindawi Limited
2017/06/07 - Atual Journal of Cellular Biochemistry (1097-4644) Wiley (John Wiley & Sons)
2017/03/17 - Atual Journal of Functional Foods (1756-4646) Elsevier
2015/08 - Atual Toxicology Elsevier
2014/07 - Atual Marine Drugs (1660-3397) MDPI AG
2014/02/24 - Atual Journal of Pharmacy and Pharmacology (2042-7158) Wiley (Blackwell Publishing)
2013/12/10 - Atual Free Radical Research (1029-2470) Informa UK (Taylor & Francis)
2013/05/10 - Atual Anti-Cancer Agents in Medicinal Chemistry (1871-5206) Bentham Science
2012/08/05 - Atual Journal of Clinical Toxicology (2161-0495) OMICS Publishing Group
2012/07/26 - Atual International Journal of Molecular Sciences (1422-0067) MDPI AG
2012/07 - Atual Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2012/05 - Atual Neurotoxicity Research (1476-3524) Springer-Verlag
2012/03/28 - Atual Chemotherapy (1421-9794) S. Karger AG
2012/02 - Atual Toxicology and Applied Pharmacology (1096-0333) Elsevier
2012/01/11 - Atual European Journal of Medicinal Plants (2231-0894) Sciencedomain International
2010/05/17 - Atual Current Drug Targets (1389-4501) Bentham Science
2009/09/09 - Atual Free Radical Biology and Medicine (0891-5849) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/11/01 - 2022/01/20 Independent Study in Exercise Physiology and Laboratory Practice - Estudo Independente em Fisiologia do Exercício e Prática Laboratorial (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal
2020/03/01 - 2021/06/30 Biochemistry of the exercise - Bioquímica do Exercício Ciências do Desporto (Licenciatura) Universidade de Coimbra Faculdade de Ciências do Desporto e Educação Física, Portugal

Tutoria

Tópico Nome do aluno
2017/01 - 2017/06 Cellular Biology Joana Faria
2017/01 - 2017/06 Cellular Biology José Baptista
2015/01 - 2015/06 Cellular Biology Cátia Seabra
2015/01 - 2015/06 Cellular Biology Nuno Beltrão
2014/09 - 2014/12 Mitochondrial physiology Francisca Moura
2013/01 - 2013/06 Mitochondria physiology Ana Oliveira
2009 - 2010 Mitochondrial physiology Estela Alves
2006 - 2007 Cellular Biology Ana Filipa Branco
Distinções

Prémio

2015 New Investigator Award for an Outstanding Work
2014 Outstanding communication
2006 Graduate Student/Postdoc Award for Presentation of Scientific Work
2004 Best Young Researcher in Basic Research
Sociedade Portuguesa de Cardiologia, Portugal
2003 Award Aventis for Scientific Research
2002 Prize for Merit from University of Coimbra
Universidade de Coimbra, Portugal

Outra distinção

2003 PRODEP III (Education Operational Program III)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal