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Summary: The work developed during my career resulted on the advancement of knowledge on the molecular mechanisms driving aging and disease. During my PhD, I demonstrated that DNA repair proteins could act simultaneously in several repair pathways (EMBO J. PMID: 16957781; MCB, PMID: 18809580). During my 4-years postdoctoral studies at CNIO, Madrid I chase my interests in disease and aging studying to a deeper knowledge the pathways controlled by telomeres and telomerase on tissue homeostasis and regeneration (Aging Cell, PMID: 21426483; Cell Reports, PMID: 23022483; Aging Cell, PMID: 23107558). In particular, I established a novel anti-aging gene therapy by incorporating telomerase on last-generation AAV9 viral vectors (Embo Mol Med, PMID: 22585399). These discoveries resulted in two patents supporting feasible anti-aging tools (EP14382311.0, EP10168341.5). During 2013 I moved to IMM-JLA, Lisbon where I got a 5-year competitive contract from FCT (FCT Investigator Program) where I score in the 1st position at the Medical Sciences panel. Here I`ve shown the potential use of lncRNAs in the reprogramming of aged cells (NatCommunications, PMID:29311544). During 2018 I moved to Aveiro as an Assistant Professor / Group Leader at the Department of Medical Sciences / iBiMED, UA, where I´m currently developing my career. Here, we are unravelling the properties of lncRNAs in cancer and ageing. In addition, we are studying the properties of stem cells that make them bona-fide models of cancer, supporting their role as reservoirs of cancer immunogens, and potentially supporting anti-cancer immunotherapies. We have published works on the biology of stem cells and in the role of lncRNAs in cancer and aging (Aging Cell, PMID:30456884; NatCommunications, PMID: 36114205; MTNA, PMID: 37680988). My track record and trajectory demonstrate an accumulated experience and maturity under diverse settings. During 2014, 2017, 2020 and 2022 I received strategic grants from FCT totaling more than 1,1M euros (as Pi and Co-Pi). Additionally, as coordinator of IBIMED I´m directly responsible for a team of 5 technicians, 1 junior and 1 assistant researcher, and for managing the 1.35M € budget of our research unit.
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Identificação

Identificação pessoal

Nome completo
Bruno Bernardes de Jesus

Nomes de citação

  • Bernardes de Jesus, Bruno

Identificadores de autor

Ciência ID
AB1E-11CF-D3A5
ORCID iD
0000-0002-6407-3466

Endereços de correio eletrónico

  • brunob.jesus@ua.pt (Profissional)

Telefones

Telemóvel
  • 911701386 (Pessoal)

Moradas

  • iBiMED - Institute of Biomedicine, Universidade de Aveiro, Campus Universitario de Santiago, Agra do Crasto – Edificio 30, 3810-193, Aveiro, Aveiro, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2008
Concluído
 Science du vivant - aspects moléculaires et cellulaires de la biologie (Doutoramento)
Institut de Génétique et de Biologie Moléculaire et Cellulaire, França
"Analyse du rôle de XPA et XPC dans les premières étapes du mécanisme de réparation par excision de nucléotides" (TESE/DISSERTAÇÃO)
 sem classificação, decreto nº2002-481 de 8 Abril d
2003
Concluído
 Bioquimica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Licenciatura em Bioquimica" (TESE/DISSERTAÇÃO)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/04/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Aveiro Instituto de Biomedicina, Portugal
2003/10/05 - 2004/06/30 Monitor (Docente Universitário) Universidade de Aveiro, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/06/01 - Atual Membro do Conselho da Unidade - Departamento de Ciências Médicas Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/04/01 - Atual Coordenador do IBIMED Universidade de Aveiro Instituto de Biomedicina, Portugal
2015/05/01 - 2018/03/31 Staff Scientist (FCT Investigator) Instituto de Medicina Molecular, Portugal
2013/08/01 - 2015/04/30 Postdoctoral fellow Instituto de Medicina Molecular, Portugal
2009/03/01 - 2013/07/31 Postdoctoral fellow at CNIO (Madrid). Centro Nacional de Investigaciones Oncológicas, Espanha
2004/09/01 - 2008/11/21 Doutoramento en Biologia molecular e celular Institut de Génétique et de Biologie Moléculaire et Cellulaire, França
1998/09/01 - 2003/09/24 Licenciatura em Bioquimica Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/01 - Atual Liga Portuguesa Contra o Cancro – Bolsa Dário Cruz (Proposal title: Non-coding transcripts associated to DNA damage repair promote breast cancer chemotherapy resistance)
Bolsa Dário Cruz
Investigador responsável
Liga Portuguesa Contra o Cancro

Projeto

Designação Financiadores
2022/03/01 - Atual Coordinator of the iBiMED funds, namely its components Basic (UIDB/04501/2020 - €596 557,80) and Programmatic (UIDP/04501/2020 - €770 000,00)
UIDB/04501/2020/ UIDP/04501/2020
Investigador responsável
2023/03/06 - 2026/03/05 Transient pluripotent states as novel reservoirs of cancer-specific antigens
2022.01199.PTDC
Investigador responsável
Fundação para a Ciência e a Tecnologia
2023/03/06 - 2026/03/05 Estados pluripotentes transitórios como novos reservatórios de antigénios específicos contra o cancro
2022.01199.PTDC
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/17 - 2024/01/16 Barreiras metabólicas na transdiferenciação celular: novas oportunidades para a regeneração cardíaca
EXPL/BIA-CEL/0358/2021
10.54499/EXPL/BIA-CEL/0358/2021
Universidade de Aveiro, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/05/01 - 2023/03/31 Investigação do papel dos RNAs não-codificantes longos na regeneração cardíaca.
ERA-CVD/0001/2018
10.54499/ERA-CVD/0001/2018
Investigador responsável
Universidade de Aveiro, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/05/01 - 2023/03/30 ERA-CVD/0001/2018 - Investigação do papel dos RNAs não-codificantes longos na regeneração cardíaca.
ERA-CVD/0001/2018
Investigador responsável
2018/10/01 - 2022/06/30 As barreiras epigenéticas do envelhecimento na reprogramação celular
PTDC/BIA-MOL/29320/2017
Investigador
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/04 - 2021/04 The role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer.
PTDC/BTM-TEC/28534/2017
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 PTDC/BTM-TEC/28534/2017

Fundação para a Ciência e a Tecnologia
Concluído
2016/12/01 - 2021/01/31 Promoção do avanço significativo do conhecimento na área de medicina de precisão e sua translação para benefício da sociedade
SAICTPAC/0021/2015
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2020 - 2021 SIARC - Soluções integradas para a automação do rastreio de alto débito da COVID-19
SIARC - Soluções integradas para a automação do rastreio de alto débito da COVID-19
Investigador
2019 - 2020 ERCBOOST@UA - Programa de Apoio à Participação no European Research Council da Universidade de Aveiro
ERCBOOST@UA
Investigador
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/11/30 O transcriptoma não codificante em envelhecimento e pluripotência
PTDC/BIM-MED/0032/2014
Investigador responsável
Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/11 - 2018/04 The non-coding transcriptome in stemness and aging - Investigador FCT - Projecto exploratório
grant.Provided by PTCRIS: 138613
IF/00166/2014/CP1236/CT0001
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Desativado

Outro

Designação Financiadores
2020/10/01 - 2024 Portuguese representative of the Management Committee of the COST Action: CA19138 - Lobular Breast Cancer: Discovery Science
Portuguese representative of the Management Committee of the COST Action: CA19138 - Lobular Breast Cancer: Discovery Science
Investigador
Produções

Publicações

Artigo em jornal
  1. Bernardes de Jesus, Bruno. "Non-coding antisense transcripts: fine regulation of gene expression in cancer", 2022
    https://doi.org/10.1016/j.csbj.2022.10.009
Artigo em revista
  1. Ana Maria Capela; Carlota Tavares-Marcos; Hugo F. Estima-Arede; Sandrina Nóbrega-Pereira; Bruno Bernardes de Jesus. "NORAD-Regulated Signaling Pathways in Breast Cancer Progression". Cancers (2024): https://doi.org/10.3390/cancers16030636.
    10.3390/cancers16030636
  2. Júlia Tavares e Silva; João Pessoa; Sandrina Nóbrega-Pereira; Bruno Bernardes de Jesus. "The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence". Cells (2024): https://doi.org/10.3390/cells13020119.
    10.3390/cells13020119
  3. Sandrina Nóbrega-Pereira; Francisco Santos; Miguel Oliveira Santos; Teresa L. Serafim; Ana Patrícia Lopes; Diogo Coutinho; Filipa S. Carvalho; et al. "Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration". Cancer Research Communications (2023): https://doi.org/10.1158/2767-9764.CRC-22-0394.
    10.1158/2767-9764.CRC-22-0394
  4. Bruno Bernardes de Jesus. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-33013-5.
    10.1038/s41467-022-33013-5
  5. Magda Correia; Francisco Santos; Rita da Silva Ferreira; Rita Ferreira; Bruno Bernardes de Jesus; Sandrina Nóbrega-Pereira. "Metabolic Determinants in Cardiomyocyte Function and Heart Regenerative Strategies". Metabolites (2022): https://doi.org/10.3390/metabo12060500.
    10.3390/metabo12060500
  6. "Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction". Archives of medical research (2022): https://doi.org/10.1016/j.arcmed.2022.02.001.
    10.1016/j.arcmed.2022.02.001
  7. Correia, Magda; Bernardes de Jesus, Bruno; Nóbrega-Pereira, Sandrina. "Novel insights linking lncRNAS and metabolic with implications for cardiac regeneration.". Frontiers in Physiology 12 (2021): https://doi.org/10.3389/fphys.2021.586927.
    Publicado
  8. "Novel Insights Linking lncRNAs and Metabolism With Implications for Cardiac Regeneration". Frontiers in physiology (2021): https://europepmc.org/articles/PMC7987814.
    10.3389/fphys.2021.586927
  9. Bruno Bernardes de Jesus; Bruno Miguel Neves; Manuela Ferreira; Sandrina Nóbrega-Pereira. "Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines". Cancers 12 12 (2020): 3581-3581. https://doi.org/10.3390/cancers12123581.
    10.3390/cancers12123581
  10. Bernardes de Jesus, Bruno; Santos, Francisco; Correia, Magda; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, Bruno. "Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?". Frontiers in physiology 11 (2020): https://europepmc.org/articles/PMC7855957.
    10.3389/fphys.2020.583191
  11. Carla Pereira Gomes; Sandrina Nóbrega-Pereira; Beatriz Domingues-Silva; Kenny Rebelo; Catarina Alves-Vale; Sérgio Pires Marinho; Tânia Carvalho; Sérgio Dias; Bruno Bernardes de Jesus. "An antisense transcript mediates MALAT1 response in human breast cancer". BMC Cancer (2019): https://doi.org/10.1186/s12885-019-5962-0.
    10.1186/s12885-019-5962-0
  12. António Sousa-Franco; Kenny Rebelo; Simão Teixeira da Rocha; Bruno Bernardes de Jesus. "LncRNAs regulating stemness in aging". Aging Cell (2019): e12870-e12870. https://doi.org/10.1111/acel.12870.
    10.1111/acel.12870
  13. Francisco Santos; Cristiana Moreira; Sandrina Nóbrega-Pereira; Bruno Bernardes de Jesus. "New Insights into the Role of Epithelial–Mesenchymal Transition during Aging". International Journal of Molecular Sciences 20 4 (2019): 891-891. https://doi.org/10.3390/ijms20040891.
    10.3390/ijms20040891
  14. Bruno Bernardes de Jesus; Sérgio Pires Marinho; Sara Barros; António Sousa-Franco; Catarina Alves-Vale; Tânia Carvalho; Maria Carmo-Fonseca. "Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency". Nature Communications 9 1 (2018): https://doi.org/10.1038/s41467-017-01921-6.
    10.1038/s41467-017-01921-6
  15. Bär, C.; De Jesus, B.B.; Serrano, R.; Tejera, A.; Ayuso, E.; Jimenez, V.; Formentini, I.; et al. "Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923378607&partnerID=MN8TOARS.
    10.1038/ncomms6863
  16. Bernardes de Jesus, B.; Blasco, M.A.. "Telomerase at the intersection of cancer and aging". Trends in Genetics 29 9 (2013): 513-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882630671&partnerID=MN8TOARS.
    10.1016/j.tig.2013.06.007
  17. Tomás-Loba, A.; Bernardes de Jesus, B.; Mato, J.M.; Blasco, M.A.. "A metabolic signature predicts biological age in mice". Aging Cell 12 1 (2013): 93-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872618059&partnerID=MN8TOARS.
    10.1111/acel.12025
  18. Vera, E.; Bernardes de Jesus, B.; Foronda, M.; Flores, J.M.; Blasco, M.A.. "Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872767063&partnerID=MN8TOARS.
    10.1371/journal.pone.0053760
  19. Bernardes de Jesus, B.; Vera, E.; Schneeberger, K.; Tejera, A.M.; Ayuso, E.; Bosch, F.; Blasco, M.A.. "Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer". EMBO Molecular Medicine 4 8 (2012): 691-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864823834&partnerID=MN8TOARS.
    10.1002/emmm.201200245
  20. de Jesus, B.B.; Blasco, M.A.. "Assessing cell and organ senescence biomarkers.". Circulation research 111 1 (2012): 97-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865396814&partnerID=MN8TOARS.
    10.1161/CIRCRESAHA.111.247866
  21. Vera, E.; Bernardes de Jesus, B.; Foronda, M.; Flores, J.; Blasco, M.. "The Rate of Increase of Short Telomeres Predicts Longevity in Mammals". Cell Reports 2 4 (2012): 732-737. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868116500&partnerID=MN8TOARS.
    10.1016/j.celrep.2012.08.023
  22. de Jesus, B.B.; Blasco, M.A.. "Potential of telomerase activation in extending health span and longevity". Current Opinion in Cell Biology 24 6 (2012): 739-743. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871938321&partnerID=MN8TOARS.
    10.1016/j.ceb.2012.09.004
  23. Bernardes De Jesus, B.; Blasco, M.A.. "Aging by telomere loss can be reversed". Cell Stem Cell 8 1 (2011): 3-4. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650980433&partnerID=MN8TOARS.
    10.1016/j.stem.2010.12.013
  24. de Jesus, B.B.; Schneeberger, K.; Vera, E.; Tejera, A.; Harley, C.B.; Blasco, M.A.. "The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence". Aging Cell 10 4 (2011): 604-621. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960322707&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2011.00700.x
  25. Oksenych, V.; De Jesus, B.B.; Zhovmer, A.; Egly, J.-M.; Coin, F.. "Molecular insights into the recruitment of TFIIH to sites of DNA damage". EMBO Journal 28 19 (2009): 2971-2980. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350566800&partnerID=MN8TOARS.
    10.1038/emboj.2009.230
  26. Natal-Da-Luz, T.; Tidona, S.; Jesus, B.; Morais, P.V.; Sousa, J.P.. "The use of sewage sludge as soil amendment. the need for an ecotoxicological evaluation". Journal of Soils and Sediments 9 3 (2009): 246-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650851488&partnerID=MN8TOARS.
    10.1007/s11368-009-0077-x
  27. De Jesus, B.M.B.; Bjørås, M.; Coin, F.; Egly, J.M.. "Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC". Molecular and Cellular Biology 28 23 (2008): 7225-7235. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349187237&partnerID=MN8TOARS.
    10.1128/MCB.00781-08
  28. D'Errico, M.; Parlanti, E.; Teson, M.; De Jesus, B.M.B.; Degan, P.; Calcagnile, A.; Jaruga, P.; et al. "New functions of XPC in the protection of human skin cells from oxidative damage". EMBO Journal 25 18 (2006): 4305-4315. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748944305&partnerID=MN8TOARS.
    10.1038/sj.emboj.7601277
Capítulo de livro
  1. Nóbrega-Pereira, Sandrina; de Jesus, Bruno Bernardes. "Cellular Reprogramming and Aging". In Concepts and Applications of Stem Cell Biology, 73-91. Springer International Publishing, 2020.
    Publicado • 10.1007/978-3-030-43939-2_5
Poster em conferência
  1. Ana Maria Capela; Catarina Alves-Vale; Marcos, Carlota; Bruno Pereira; Bernardes de Jesus, Bruno. "The role of the lncRNA NORAD in DNA Damage Repair and Signaling". Trabalho apresentado em RNA in disease, 2023.
  2. Cazaux Mateus, Francisca; Bernardes de Jesus, Bruno. "Strategies for Cancer Immunotherapy Using Induced Pluripotent Stem Cells (iPSC) and Embryonic Stem Cells (ESC)". Trabalho apresentado em iBiMED Symposium, 2022.
  3. da Rocha, Simão T.; Arez, Maria; Eckersey-Maslin, Melanie ; Klobucar, Tajda; Lopes, João Von Gilsa; Krueger, Felix; Raposo, Ana Cláudia; et al. "Strategies to avoid imprinting defects in induced pluripotent stem cells.". Trabalho apresentado em ISSCR 2022 Annual Meeting - International Society for Stem Cell Research,, 2022.
  4. Arez, Maria; Eckersley-Maslin, Melanie; Von Gilsa, João; GENDREL, ANNE-VALERIE; Raposo, Ana; Bernardes de Jesus, Bruno; da Rocha, Simão T.. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, 2019.

Propriedade Intelectual

Patente
  1. Blasco Marhuenda Maria Antonia; Bernardes De Jesus Bruno; Baer Christian; Serrano Ruiz Rosa María; Bosch I Tubert Fàtima; Ayuso Eduard; Formentini Ivan; Bobadilla Maria; Mizrahi Jacques. 2017. "Telomerase Reverse Transcriptase-based Therapies For Treatment Of Conditions Associated With Myocardial Infarction". Estados Unidos.
  2. Blasco Marhuenda Maria Antonia; Bernardes Bruno; Bosch Tubert Fatima; Ayuso Eduard. 2012. "Telomerase Reverse Transcriptase For Protection Against Ageing".

Outros

Outra produção
  1. Mitochondrial metabolism drives hypercholesterolemia-induced breast cancer cell migration. 2022. https://doi.org/10.21203/rs.3.rs-1338648/v1.
    10.21203/rs.3.rs-1338648/v1
  2. Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs. 2020. https://doi.org/10.1101/2020.11.20.370973.
    10.1101/2020.11.20.370973
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/12/06 Aging barriers in the transdifferentiation of fibroblasts into induced cardiac-like myocytes 3rd RESETageing CONFERENCE
(Coimbra, Portugal)
2023 RNA IN DISEASE IX ptRNA meeting 26 • 27 January 2023 Lisbon
2022 The Bioengineering ONE HEALTH ALLIANCE IN 2050 A One-Day Voyage into the Future 27 October 2022 Porto, Hall of Biodiversity – Ciência Viva Center
2022 CICLO DE CAFÉS DE CIÊNCIA COMUNIDADES SAUDÁVEIS SERÁ O ENVELHECIMENTO REVERSIVEL? 5ª feira | 9 junho '22 | 15h00 › 15h45
2021/03/29 Aging barriers in cellular reprogramming SPB Workshop on Biology of aging
2012 Role of telomeres and telomerase in aging - 12th Topic day by PhD student committee of the Albert Bonniot Institute. Grenoble, France 12th Topic day by PhD student committee of the Albert Bonniot Institute. Grenoble, France
2010 A TERT-based intervention late in life delays aging and extends lifespan without increasing cancer. - EMBO Conference on Telomeres and the DNA Damage Response, Marseille, France EMBO Conference on Telomeres and the DNA Damage Response, Marseille, France
2010 A TERT-based intervention late in life delays aging and extends lifespan without increasing cancer - Molecular Genetics of Aging, Cold Spring Harbor, NY Molecular Genetics of Aging, Cold Spring Harbor, NY
2006 The role of XPC in NER - EU-RTN Annual Meeting, Marseille, France EU-RTN Annual Meeting, Marseille, France
2005 The role of XPC in NER. - Marie-Curie Mid-term report, Rotterdam, The Netherlands Marie-Curie Mid-term report, Rotterdam, The Netherlands

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual RNA transcripts in human breast cancer - Ana Capela
Orientador
2021 - Atual Induced pluripotent stem cells (iPSC) as a model of cancer. - Francisca Mateus
Orientador
2021 - Atual PhD - UI/BD/151373/2021 - Magda Correia ¿Induced Pluripotent Stem Cells (iPSC)-based Cancer Immunotherapy¿
Orientador
2020 - Atual Induced Pluripotent Stem Cells – based cancer immunotherapy - Mariana Pinheiro
Orientador
2020 - Atual Overcoming metabolic and epigenetic barriers of direct cardiac reprogramming. - Roberta Criscuolo
Orientador
2020 - Atual Cell-based clinical therapies for spinal cord injury treatment. - Bruna Daniela Coelho da Cruz
Coorientador
2020 - Atual PhD - Francisco José Furtado Santos - SFRH/BD/146204/2019 “Exploiting the role of lncRNAs in the direct conversion of fibroblasts into cardiomyocytes and neural progenitor cells”
Orientador
2019 - Atual Endothelial progenitor cells and circulating endothelial cells in heart failure: a cross-sectional study - José Carlos Martins Lopes
Coorientador
2019 - Atual IDENTIFICATION OF REAGENTS INTENDED TO THE STUDY OF THE LONG ISOFORM OF THE NF-YA TRANSCRIPTION FACTOR - BÁRBARA FILIPA TEIXEIRA DE ARAÚJO MIRANDA
Orientador
2022 - 2023 MSc supervisor of Julia Silva
Orientador
2022 - 2023 MSc Supervisor of Carlota Marcos
Orientador
2019 - 2020 Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes - Paula Magda Teixeira Correia
Orientador
2019 - 2020 Role of long non-coding RNAs in cancer cells survival and migration
Orientador
2017 - 2018 Long non-coding RNAs as potential therapeutic targets in human breast cancer - Beatriz Silva
Orientador
2017 - 2018 Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs - Maria João de Andrade Terras Arez
Coorientador
2016 - 2017 Enhancing reprogramming and transdifferentiation through long non-coding RNAs - Miguel Torres Santana
Orientador
2016 - 2017 Unravelling the role of the long noncoding RNA NORAD in breast cancer - Catarina Alves-Vale
Orientador
2015 - 2016 A long non-coding RNA regulating cellular reprogramming. - Sara Azevedo Barros
Orientador
 Biologia Evolutiva e do Desenvolvimento, Faculdade de Ciências da Universidade de Lisboa.
2015 - 2016 Long non-coding RNA contributes to direct conversion reprogramming - António de Sousa Franco
Orientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022 - 2022 Organization of the ERA-NET INNOVATION meeting at Aveiro 7-8 of October ode 2022 INNOVATION is a funded project from ERA-NET for Research Programs on Cardiovascular Diseases (ERA-CVD) joint Translational Call 2018 (JTC 2018) (2022 - 2022)
2007 - 2007 Organization of the workshop: “EU-IP DNA Repair workshop for young scientists” May 13-16, 2007 Ghent, Belgium (2007 - 2007)
Oficina (workshop)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/11/29 - Atual Cancer immunometabolism Sitges, Barcelona, Spain|Hybrid • 29 November – 1 December 2021
2021/11/27 - Atual ISSCR/JSRM 2021 Tokyo International Symposium - Virtua Title of the poster: EXPLOITING THE ROLE OF METABOLIC CUES DURING THE CONVERSION OF MOUSE FIBROBLASTS INTO INDUCED CARDIOMYOCYTES
2021/05/19 - Atual Keystone Symposia eSymposia meeting Cancer Stem Cells: Advances in Biology and Clinical Translation | EK46 from May 19-21, 2021
2016 - Atual Keystone Symposia Conference, noncoding RNAs in health and Disease, Santa Fé, NM, USA, February 21-24, 2016 (Poster)
2022/02/09 - 2022/02/11 Attended the EMBO virtual Workshop The Epitranscriptome
2022 - 2022 ERA-Net on Cardiovascular Diseases (ERA-CVD) Symposium 2022, Riga, Latvia
2022 - 2022 Attended the International Conference Ageing With]Out[Borders in Faro, Portugal | 6-7 December 2022
2022 - 2022 Attended the Keystone Symposia meeting on Organoids as Tools for Fundamental Discovery and Translation held 4/3/2022 - 4/6/2022 at Keystone Resort.
2022 - 2022 Attended the Keystone Symposia meeting on Single Cell Biology: Pushing New Frontiers in the Life Sciences held 4/5/2022 - 4/9/2022 at Firenze Fiera - Nazioni - Virtual
2020 - 2020 Mechanisms & Models of Cancer (virtual), Cold Spring Harbor Laboratory, New York, USA, September 11-2020. Poster
Conferência
2019 - 2019 Long Noncoding RNAs: From Molecular Mechanism to Functional Genetics, Keystone Symposia, Whistler, British Columbia, Canada, February 24-28, 2019 (Poster)
2019 - 2019 The role of LncRNAs in transdifferentiation. ERA-CVD, Latvia, 14-16 May 2019 (Poster)
2017 - 2017 Stem Cell Biology, Cold Spring Harbor, NY, September 25–September 29, 2017, Poster
2014 - 2014 Regulatory & Non Coding RNAs, Cold Spring Harbor, NY, August 26 - 30, 2014. (Poster).
2013 - 2013 Telomeres and Telomerase, Cold Spring Harbor, NY, April 30–May 4, 2013. (Poster).
2012 - 2012 Role of Telomerase in tissue fibrosis and regeneration in a rodent model of myocardial infarction – a possible therapy for cardiac dysfunction. 3rd RPF Symposium (Roche), Penzberg, Germany; November 19-20, 2012 (Poster)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/15 Chair of the Thesis defense of Martín Salamini Montemurri - Title: HMGB proteins, lncRNAs, and their interaction in epithelial ovarian cancer
Presidente do júri
 Martín Salamini Montemurri (Doutoramento)
Universidade da Coruña, Espanha
2019 Modelação da Resposta Imunológica Através da Manipulação de Agregados Proteicos - Daniela Claudino Carvoeiro
Presidente do júri
 Daniela Claudino Carvoeiro (Mestrado)
2019 MSc in molecular biomedicine DANIELA CLAUDINO CARVOEIRO (Mestrado)
2018 Evolution of antifungal drug tolerance in Candida albicans - Catarina Alexandra Gomes Brinco
Presidente do júri
 Catarina Alexandra Gomes Brinco (Mestrado)
2018 MSc in Molecular Biomedicine CATARINA ALEXANDRA GOMES BRINCO (Mestrado)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual Journal of Clinical Medicine (2077-0383) MDPI AG
2018 - Atual Journal of Cell Science (1477-9137) The Company of Biologists
2018 - Atual Clinical Epigenetics (1868-7083) Springer-Verlag
2018 - Atual Cellular Oncology (1875-8606) IOS Press
2017 - Atual Nature Communications (2041-1723) Springer Science and Business Media LLC
2017 - Atual Journal of Cell Biology The Rockefeller University Press
2016 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2020 - 2023 Plos One - Academic Editor
2020 - 2022 BMC Cancer - Associate Editor

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - 2022 FCT PhD evaluation panels
2022 - 2022 University of Aveiro - PhD fellowships evaluation panel

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - Atual Director of the Committee responsible for internationalization at the Department of Medical Sciences, University of Aveiro, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2020 - Atual Arguer at the MSc in Molecular Biomedicine - Ana Rita Oliveira Silva
2020 - Atual Arguer at the MSc in Molecular Biomedicine - Glória de Fátima da Silva Figueiredo
2018 - Atual Arguer at the MSc of Molecular Biomedicine - CAROLINA NEVES CONCEIÇÃO
2022 - 2022 Opponent at the PhD defense of Alessia Costa, PhD candidate in the International PhD Program ‘Regenerative Sciences’ in Han- nover Biomedical Research School (HBRS)
Distinções

Outra distinção

2014 Investigador FCT
2012 FCT postdoctoral fellowship
2006 ARC Fellowship
2002 PRODEP fellowship for undergraduate students, Portugal