Margarida Maria F. B. e Silva is an Assistant Professor at the University of Lisbon (UL)-Faculty of Pharmacy and a Researcher at The Research Institute for Medicines (iMed.ULisboa / Metabolism, Genetics and Proteins group), an R&D Unit at the University of Lisbon. She graduated in Pharmaceutical Sciences and obtained a Ph.D. in Pharmacy (Biochemistry) in 2002 from UL. Research work has been focused on elucidating genetic/molecular determinants of drug interactions with endogenous metabolism. Relevant novel insights on mitochondrial bioenergetics underlying pharmacological or toxicological effects were reported as scientific publications. Principal investigator and team member of several projects, funded by FCT and other sources. She supervised 3 Ph.D. Doctoral fellows (concluded) and 50 Master's students. Received four scientific merit awards. Published ca. one hundred indexed peer-reviewed publications in specialized journals and interacted with 100 collaborator(s) co-authorship of scientific papers. Ongoing work involves metabolism-driven questions and related proteomic and genomic links under a Translational Biochemistry perspective (Medical and Health Sciences). She specialized in advanced analytical techniques of mass spectrometry-based metabolomics for studying small molecules as biomarkers of disease and inherent mechanisms. These approaches and current projects intersect the study of hereditary diseases of metabolism, intra- or intercellular communication, and drug-induced molecular effects with relevant impact on pharmacology, toxicology, and clinical medicine.