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I am a postdoctoral researcher at ICVS, University of Minho. I obtained a PhD in Neuroscience from the University of Bordeaux (France) in 2023, where I investigated the role of the endocannabinoid system in motivated behaviors. During my doctoral training under the supervision of Dr. Francis Chaouloff in Dr. Giovanni Marsicano’s laboratory (INSERM), I implemented a wide range of behavioral paradigms based on operant conditioning to dissect the neurobiological mechanisms underlying the dysregulated balance between food intake and physical activity observed in eating disorders. By combining behavioral neuroeconomics, pharmacological and viral approaches, my research revealed that cannabinoid type-1 (CB1) receptors located on GABAergic interneurons sex-dependently gate long-term cost-benefit decision-making between feeding and exercise. This work provided me with a strong foundation in experimental design and circuit –level approaches, resulting in six peer-reviewed publications including three as co-first author, and the presentation of my work at major international conferences (FENS, SFN). Following my PhD and first postdoctoral experience, I strategically broadened my research focus and methodological expertise. Thus, in 2025, I joined the laboratory of Dr. Ana João Rodrigues (ICVS, Braga, Portugal), recognized for its strong technical expertise in the field of reward and aversion, to further develop my independent research profile. This transition enabled me to acquire new methodologies, including single-cell calcium imaging, optogenetics and advanced computational analyses enabling a deeper understanding of neural population dynamics that support adaptive and maladaptive behavior.
Identificação

Identificação pessoal

Nome completo
Imane Maxine Hurel

Nomes de citação

  • Hurel, Imane

Identificadores de autor

Ciência ID
7E14-C7DC-93EC
ORCID iD
0000-0001-7392-6427

Endereços de correio eletrónico

  • b15038@med.uminho.pt (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia das Ciências do Comportamento

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2018/11/01 - 2023/05/16
Concluído
PhD in "Neurosciences" (Doktor (PhD))
Université de Bordeaux École Doctorale des Sciences de la Vie et de la Santé, França
"Role of the endocannabinoid system in the motivational balance between feeding and physical activity in mice " (TESE/DISSERTAÇÃO)
2023/01/09 - 2023/01/20
Concluído
Python course (Postgraduate Certificate)
Aquineuro, França
2016 - 2018
Concluído
International Neurosciences (Master)
Université de Bordeaux Collège Sciences et Technologies, França
"Role of the cannabinoid type 1 (CB1) receptor in the choice between physical activity and palatable food in mice" (TESE/DISSERTAÇÃO)
2014 - 2016
Concluído
Science and technology (Licence)
Université de Bordeaux Collège Sciences et Technologies, França
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2025/07/22 - Atual Pós-doutorado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/05/17 - 2025/01/30 Pós-doutorado (Investigação) INSERM, França
Neurocentre Magendie, França

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2018/11/01 - 2023/05/16 PhD student INSERM, França
Neurocentre Magendie, França
Projetos

Bolsa

Designação Financiadores
2025/07/22 - Atual Challenging current models of Valence encoding in the mammalian brain
Investigador Pós-doutorado
Laboratório Associado ICVS 3B's, Portugal
European Research Council
Em curso
2024/06/02 - 2025/01/31 Towards the identification of novel treatments for addiction and comorbid psychiatric symptoms
Investigador Pós-doutorado
Institut de Recherche en Santé Publique
Em curso
2018/11/01 - 2024/06/01 Mitochondrial Cannabinoid Receptors in the Brain (MiCaBra)
PhD fellowship and Post doc
INSERM, França
European Research Council
Concluído
Produções

Publicações

Artigo em revista
  1. Yamuna Mariani; Tommaso Dalla-Tor; Tommaso Garavaldi; Francisca Julio-Kalajzic; Doriane Gisquet; Paula Gomez-Sotres; Astrid Cannich; et al. "Astroglial CB1 Reveal Sex-Specific Synaptic Effects of Amphetamine". Glia (2025): http://dx.doi.org/10.1002/glia.70026.
    10.1002/glia.70026
  2. Maria-Carmen Medrano; Imane Hurel; Emma Mesguich; Bastien Redon; Christopher Stevens; François Georges; Miriam Melis; Giovanni Marsicano; Francis Chaouloff. "Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons". Addiction Biology (2021): https://doi.org/10.1111/adb.12967.
    10.1111/adb.12967
  3. Imane Hurel; Carolina Muguruza; Bastien Redon; Giovanni Marsicano; Francis Chaouloff. "Cannabis and exercise: Effects of ¿9-tetrahydrocannabinol on preference and motivation for wheel-running in mice". Progress in Neuro-Psychopharmacology and Biological Psychiatry (2021): http://dx.doi.org/10.1016/j.pnpbp.2020.110117.
    10.1016/j.pnpbp.2020.110117
  4. Imane Hurel; Bastien Redon; Amandine Scocard; Meryl Malezieux; Giovanni Marsicano; Francis Chaouloff. "Beyond the Activity-Based Anorexia Model: Reinforcing Values of Exercise and Feeding Examined in Stressed Adolescent Male and Female Mice". Frontiers in Pharmacology (2019): http://dx.doi.org/10.3389/fphar.2019.00587.
    10.3389/fphar.2019.00587
  5. Muguruza, C; Bastien Redon; Giulia R. Fois; Imane Hurel; Amandine Scocard; Claire Nguyen; Christopher Stevens; et al. "The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors". JCI Insight (2019): http://dx.doi.org/10.1172/jci.insight.126190.
    10.1172/jci.insight.126190
  6. Bastien Redon; Imane Hurel; Giovanni Marsicano; Francis Chaouloff. "An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice". BIO-PROTOCOL (2019): http://dx.doi.org/10.21769/bioprotoc.3381.
    10.21769/bioprotoc.3381
Poster em conferência
  1. Hurel, Imane; Redon, Bastien; Fayad, Rim; Gisquet, Doriane; Julio-Kalajzic, Francisca; Cannich, Astrid; Di Lodovico, Laura; et al. Autor correspondente: Chaouloff, Francis. "CB1 receptors in accumbal GABAergic interneurons regulate cost sensitivity for exercise". Trabalho apresentado em 11th symposium of the Neurocentre Magendie, 2024.
  2. Hurel, Imane; Redon, Bastien; Fayad, Rim; Di Lodovico, Laura; Bellocchio, Luigi; Cannich, Astrid; Gisquet, Doriane; et al. Autor correspondente: Chaouloff, Francis. "Neuroeconomics reveal that CB1 receptors in accumbal GABAergic interneurons gate running, but not feeding, motivation.". Trabalho apresentado em SEIC meeting, 2023.
  3. Hurel, Imane; Redon, Bastien; Mesguich, Emma; Marsicano, Giovanni; Chaouloff, Francis. Autor correspondente: Chaouloff, Francis. "Feeding and exercise essential values examined in cannabinoid type-1 (CB1) receptor mutant mice exposed to closed economy conditions". Trabalho apresentado em FENS forum, 2022.
  4. Hurel, Imane; Redon, Bastien; Mesguich, Emma; Bellocchio, Luigi; Gisquet, Doriane; Julio-Kalajzic, Francisca; Marsicano, Giovanni; Chaouloff, Francis. "Feeding and exercise essential values examined in cannabinoid type-1 (CB1) receptor mutant mice exposed to closed economy conditions". Trabalho apresentado em SFN San diego USA, 2022.
  5. Hurel, Imane; Redon, Bastien; Marsicano, Giovanni; Chaouloff, Francis. Autor correspondente: Chaouloff, Francis. "Cannabinoid type-1 (CB1) receptors control the choice between feeding and exercise in a closed economy setting.". Trabalho apresentado em International virtual meeting NeuroFrance 2021, 2021.
  6. Hurel, Imane; Redon, Bastien; Scocard, Amandine; Malezieux, Meryl; Marsicano, Giovanni; Chaouloff, Francis. Autor correspondente: Chaouloff, Francis. "Reinforcing values of exercise and feeding examined in stressed adolescent male and female mice.". Trabalho apresentado em 6th Bordeaux Neurocampus Conference, Normal and pathological reward processing, 2019.
Pré-impressão
  1. Imane Hurel; Rim Fayad; Bastien Redon; Doriane Gisquet; Francisca Julio-Kalajzic; Abel Eraso-Pichot; Thierry Lesté-Lasserre; et al. "Ventromedial striatal GABAergic interneurons sex-dependently gate cost-benefit choices between food and exercise". 2026. https://doi.org/10.64898/2026.03.22.713369.
    10.64898/2026.03.22.713369
Tese / Dissertação
  1. "Role of the endocannabinoid system in the motivational balance between feeding and physical exercise in mice". Doutoramento, Université de Bordeaux Collège Sciences de la Santé, 2023. https://theses.hal.science/tel-04390417.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023 Neuroeconomics reveal the key role of ventrostriatal cannabinoid type-1 (CB1) receptors in exercice motivation 10th symposium of the Neurocentre Magendie
Neurocentre Magendie (Bordeaux, França)
2021 Choosing between exercise and food in a closed economy setting: role of CB1 receptors 13th nutrition-neuroscience day
Nutrineuro (Bordeaux, França)
2020/01 Choosing between exercise and food in a closed economy setting: role of CB1 receptors Hottopics
Neurocentre Magendie (Bordeaux, França)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021 - 2022 CB1 receptors and choice between physical activity and food intake under closed economy conditions.
Coorientador de Stella Carbonel-Rabocelli
Master in neuroscience (Mestrado)
Université de Picardie Jules Verne, França
2021/01 - 2021/06 CB1 receptors on GABAergic neurons control the choice between exercise and food in a closed economy setting
Coorientador de Maria Sole Cupani
Master in neuroscience (Mestrado)
Université de Bordeaux Collège Sciences de la Santé, França
2020/01 - 2020/06 Effect of DELTA-9-TETRAHYDROCANNABINOL on motivation for physical activity
Coorientador de Lucie Cabiro
Master in neuroscience (Mestrado)
Université de Toulouse, França
2018/01 - 2018/06 Impacts of wheel-running on the synaptic strength of excitatory inputs to midbrain dopamine neurons
Coorientador de Emma Mesguich
Master in neuroscience (Mestrado)
Université de Bordeaux, França

Tutoria

Tópico Nome do aluno
2023/10 - 2025/01 Closed economy paradigm in mice Rim Fayad
2022/01 - 2022/08 Are dopaminergic neurons important for wheel running performances ? Christian Poletto
2019 - 2022 Craving for physical exercise increases the synaptic strength of excitatory inputs to midbrain dopamine neurons Emma Mesguich
Distinções

Prémio

2024 Best Post doctoral poster presentation
Neurocentre Magendie, França