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Dr. C. Palladino (CP) is a researcher at iMed.ULisboa, Faculty of Pharmacy, University of Lisbon. The epidemiology of infectious disease (malaria, HIV, HCV) and antimicrobial drug effectiveness, resistance and treatment optimization have been the bedrock of her professional research, mostly managing and analysing data to generate understanding to be exploited by health services/agencies to optimise public health policy/practice. Throughout her academic training and her long professional career, CP worked at internationally recognised centres of excellence (Marañón Hospital-Spain 2006-2011; INSERM-France 2005-2006; National Institute for Infectious Diseases Spallanzani-Italy 2004-2005; The University of Edinburgh-UK 2003-2004; Centre National de Recherche sur le Paludisme-Burkina Faso 2000) where she acquired expertise in infectious disease and advanced statistical analysis of epidemiological data. Her work has involved multi-disciplinary collaboration within the framework of large European and African cohorts (FCT grant PTDC/SAU-EPI/122400/2010; Palladino et al, DOI:10.1371/journal.pone.0181352). Her research outputs include a book chapter (HIV, ART); an article on malaria for scientific divulgation; 28 peer-reviewed publications (for most of which she is the principal or a major author; 365 total cites) in journals of 1st quartile (AIDS, PLoS One) and 1st decile (Pediatr Infect Dis J); 19 publications in conference proceedings; 35 and 24 abstracts at international and national congresses; 17 oral communications, receiving 6 prizes (e.g. Young Investigator Award - CROI2019). Remarkably, her publications on the use of new antiretrovirals for children have contributed to pediatric guidelines, being cited on the NIH, PENTA, Spanish, Italian and Mexican HIV guidelines (Palladino et al, 2015 DOI:10.1097/QAD.0000000000000819). She has worked with the WHO at HIV treatment optimization (Penazzato et al, 2017 DOI:10.1097/COH.0000000000000378). During the last 5 years, CP published 8 original papers, two as corresponding author; has joined two projects on HIV/HCV-coinfection as associated researcher (funder: Spanish Institute of Health Carlos III) and has been Assistant Professor of Statistics (University of Lisbon); has worked on HCV drugs/resistance to inform treatment implementation policy (Palladino et al, 2020 DOI:10.1038/s41598-020-69692-7; Palladino et al, 2018 DOI:10.1038/s41598-018-30528-0). CP is reviewer for Q1 journals (publons.com/a/1212762/) and ESCAIDE; she collaborates as mentor at the Abstract Mentor Programme of the IAS/AIDS conferences to support young researchers of low income countries; she is a consultative expert for the Portuguese National Authority of Medicines & Health Products and collaborator of the Global Burden of Disease. She has conceived, organised and co-ordinated four grant-funding proposals, e.g. CEECIND/00566/2017 ¿Throughcare for prisoners in Portugal¿ (classification 9.2/10).
Identificação

Identificação pessoal

Nome completo
Claudia Palladino

Nomes de citação

  • Palladino, Claudia

Identificadores de autor

Ciência ID
721D-6851-20D5
ORCID iD
0000-0002-8148-0928

Endereços de correio eletrónico

  • claudiapalladino@ff.ulisboa.pt (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Italiano (Idioma materno)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2)
Produções

Publicações

Artigo em revista
  1. GBD 2021 Collaborators. "Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis of the Global Burden of Disease Study 2021". The Lancet Neurology (2023):
    Acesso aberto • Aceite para publicação
  2. GBD 2019 Europe Hepatitis B & C Collaborators; Paolo Angelo Cortesi; Carla Fornari; Sara Conti; Ippazio Cosimo Antonazzo; Pietro Ferrara; Ayman Ahmed; et al. "Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019". The Lancet Public Health 8 9 (2023): e701-e716. https://pubmed.ncbi.nlm.nih.gov/37633679/.
    Acesso aberto • Publicado • 10.1016/S2468-2667(23)00149-4
  3. Palladino, Claudia; GBD 2019 Europe Hepatitis B & C Collaborators. "Impact of the 2008 economic crisis on the burden of HBV and HCV disease in Southern European Countries". BMC Public Health (2023):
    Em revisão
  4. Francisco Martin; José Maria Marcelino; Claudia Palladino; Inês Bártolo; Susana Tracana; Inês Moranguinho; Paloma Gonçalves; et al. "Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.01634-22.
    10.1128/spectrum.01634-22
  5. Martínez-Román, Paula; Crespo-Bermejo, Celia; Valle-Millares, Daniel; Lara-Aguilar, Violeta; Arca-Lafuente, Sonia; Martín-Carbonero, Luz; Ryan, Pablo; et al. "Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance". Journal of Clinical Medicine 11 13 (2022): 3579-3594. http://dx.doi.org/10.3390/jcm11133579.
    10.3390/jcm11133579
  6. Valle-Millares, Daniel; Brochado-Kith, Óscar; Martín-Carbonero, Luz; Domínguez-Domínguez, Lourdes; Ryan, Pablo; De los Santos, Ignacio; De la Fuente, Sara; et al. "Different HCV Exposure Drives Specific miRNA Profile in PBMCs of HIV Patients". Biomedicines 9 11 (2021): 1627. http://dx.doi.org/10.3390/biomedicines9111627.
    Acesso aberto • Publicado • 10.3390/biomedicines9111627
  7. Claudia Palladino; Ifeanyi Jude Ezeonwumelu; Irene Mate-Cano; Pedro Borrego; Paula Martínez-Román; Sonia Arca-Lafuente; Salvador Resino; Nuno Taveira; Verónica Briz. "Epidemic history and baseline resistance to NS5A-specific direct acting drugs of hepatitis C virus in Spain". Scientific Reports 10 1 (2020): https://doi.org/10.1038/s41598-020-69692-7.
    10.1038/s41598-020-69692-7
  8. Maria Rosa López-Huertas; Claudia Palladino; Marta Garrido-Arquero; Beatriz Esteban-Cartelle; Marta Sánchez-Carrillo; Paula Martínez-Román; Luz Martín-Carbonero; et al. "HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-41788-9.
    10.1038/s41598-019-41788-9
  9. Claudia Palladino; Ifeanyi Jude Ezeonwumelu; Rute Marcelino; Verónica Briz; Inês Moranguinho; Fátima Serejo; José Fernando Velosa; et al. "Epidemic history of hepatitis C virus genotypes and subtypes in Portugal". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-30528-0.
    10.1038/s41598-018-30528-0
  10. Palladino, C.; Esteban-Cartelle, B.; Mate-Cano, I.; Sánchez-Carrillo, M.; Resino, S.; Briz, V.. "Prevalence of relevant NS5A resistance-associated substitutions to elbasvir in genotype 1a hepatitis C virus patients in Spain,Frecuencia de sustituciones relevantes asociadas a resistencia en la región NS5A a elbasvir en el virus de la hepatitis C en pacientes con genotipo 1a en España". Enfermedades Infecciosas y Microbiologia Clinica 36 5 (2018): 262-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019488063&partnerID=MN8TOARS.
    10.1016/j.eimc.2017.03.008
  11. Penazzato, M.; Palladino, C.; Sugandhi, N.. "Prioritizing the most needed formulations to accelerate paediatric antiretroviral therapy scale-up". Current Opinion in HIV and AIDS 12 4 (2017): 369-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017580499&partnerID=MN8TOARS.
    10.1097/COH.0000000000000378
  12. Martin, F.; Palladino, C.; Mateus, R.; Bolzan, A.; Gomes, P.; Brito, J.; Carvalho, A.P.; et al. "Early infant diagnosis of HIV-1 infection in Luanda, Angola, using a new DNA PCR assay and dried blood spots". PLoS ONE 12 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85024842860&partnerID=MN8TOARS.
    10.1371/journal.pone.0181352
  13. Palladino, C.; Sánchez-Carrillo, M.; Mate-Cano, I.; Vázquez-Morón, S.; Jimenez-Sousa, M.Á.; Gutiérrez-Rivas, M.; Resino, S.; Briz, V.. "Low frequency of NS5A relevant resistance-associated substitutions to Elbasvir among hepatitis C virus genotype 1a in Spain: A cross-sectional study". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020415072&partnerID=MN8TOARS.
    10.1038/s41598-017-02968-7
  14. Falcon-Neyra, L.; Palladino, C.; Gomez, M.L.N.; Soler-Palacin, P.; Gonzalez-Tome, M.I.; De Ory, S.J.; Frick, M.A.; et al. "Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study". Medicine (United States) 95 24 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84976351380&partnerID=MN8TOARS.
    10.1097/MD.0000000000003842
  15. Martin, Francisco; Palladino, Claudia; Mateus, Rita; Clemente, Sofia; Gomes, PerpeTua; Taveira, Nuno. "Evaluation of an In-house Molecular HIV-1 Test to Assess Mother-to-Child HIV-1 Transmission in Angola (the APEHC Cohort)". JAIDS Journal of Acquired Immune Deficiency Syndromes (2016): https://publons.com/wos-op/publon/40211725/.
    10.1097/01.QAI.0000479713.77468.97
  16. Martínez-Bonet, M.; Palladino, C.; Briz, V.; Rudolph, J.M.; Fackler, O.T.; Relloso, M.; Muñoz-Fernandez, M.A.; Madrid, R.. "A Conserved GPG-Motif in the HIV-1 Nef Core Is required for principal nef-activities". PLoS ONE 10 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84956906858&partnerID=MN8TOARS.
    10.1371/journal.pone.0145239
  17. Palladino, C.; Gómez, M.L.N.; Soler-Palacín, P.; González-Tomé, M.I.; De Ory, S.J.; Espiau, M.; Hoyos, S.P.; et al. "Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice". AIDS 29 16 (2015): 2155-2159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964904223&partnerID=MN8TOARS.
    10.1097/QAD.0000000000000819
  18. Wiessing, L.; Ferri, M.; Grady, B.; Kantzanou, M.; Sperle, I.; Cullen, K.J.; Hatzakis, A.; et al. "Hepatitis C virus infection epidemiology among people who inject drugs in europe: A systematic review of data for scaling up treatment and prevention". PLoS ONE 9 7 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84904987089&partnerID=MN8TOARS.
    10.1371/journal.pone.0103345
  19. Bártolo, I.; Zakovic, S.; Martin, F.; Palladino, C.; Carvalho, P.; Camacho, R.; Thamm, S.; Clemente, S.; Taveira, N.. "HIV-1 diversity, transmission dynamics and primary drug resistance in Angola". PLoS ONE 9 12 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84916919875&partnerID=MN8TOARS.
    10.1371/journal.pone.0113626
  20. Palladino, C.; Briz, V.; Bellón, J.M.; Climent, F.J.; De Ory, S.J.; Mellado, M.J.; Navarro, M.L.; et al. "Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012". PLoS ONE 9 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84900338272&partnerID=MN8TOARS.
    10.1371/journal.pone.0096307
  21. Palladino, C.; Briz, V.; Bellón, J.M.; Bártolo, I.; Carvalho, P.; Camacho, R.; Muñoz-Fernández, M.Á.; et al. "Predictors of attrition and immunological failure in HIV-1 patients on highly active antiretroviral therapy from different healthcare settings in mozambique". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893370669&partnerID=MN8TOARS.
    10.1371/journal.pone.0082718
  22. Briz, V.; León-Leal, J.A.; Palladino, C.; Moreno-Perez, D.; De Ory, S.J.; De José, M.I.; González-Tomé, M.I.; et al. "Potent and sustained antiviral response of raltegravir-based highly active antiretroviral therapy in HIV type 1-infected children and adolescents". Pediatric Infectious Disease Journal 31 3 (2012): 273-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857639900&partnerID=MN8TOARS.
    10.1097/INF.0b013e31824580e8
  23. Briz, V.; Palladino, C.; Navarro, M.L.; Jiménez de Ory, S.; González-Tomé, M.I.; León, J.; Núñez-Cuadros, E.; et al. "Etravirine-based highly active antiretroviral therapy in HIV-1-infected paediatric patients". HIV Medicine 12 7 (2011): 442-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959975874&partnerID=MN8TOARS.
    10.1111/j.1468-1293.2010.00907.x
  24. Santos, Â.; Clemente, S.; Bártolo, I.; Palladino, C.; Cavaco-Silva, P.; Franco, V.; Epalanga, M.; Pinto, R.; Taveira, N.. "Evaluation of the diagnostic performance of the rapid test VIKIA HIV1/2 in a highly complex HIV-1 epidemic". Diagnostic Microbiology and Infectious Disease 71 1 (2011): 90-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051663920&partnerID=MN8TOARS.
    10.1016/j.diagmicrobio.2011.06.002
  25. Palladino, C.; Climent, F.J.; José, M.I.D.; Jimenez De Ory, S.; Bellón, J.M.; Guillén, S.; Gurbindo, M.D.; et al. "Causes of death in pediatric patients vertically infected by the human immunodeficiency virus type 1 in Madrid, Spain, from 1982 to mid-2009". Pediatric Infectious Disease Journal 30 6 (2011): 495-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958016577&partnerID=MN8TOARS.
    10.1097/INF.0b013e318211399f
  26. Climent Alcala, F. J.; Osona, B. L.; Fernandez, G. A. M.; Moriano, L. S.; Cerpa, M.; Gonzalez, J. M. I.; Palladino, C.. "EVALUATION OF THE DURATION OF HAART IN CHILDREN INFECTED BY HIV". Acta Paediatrica 99 (2010): 90-90. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000284616200166&KeyUID=WOS:000284616200166.
  27. Palladino, C.; Briz, V.; Tome, G.; Leal, J. A. L.; Navarro, M. L.; de Jose, I.; Ramos, J. T.; Munoz-Fernandez, A.. "EVALUATION OF THE EFFECT OF ENFUVIRTIDE IN HIV-1 PAEDIATRIC PATIENTS OUTSIDE CLINICAL TRIALS". Child Care Health and Development 36 (2010): 76-76. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000273636500164&KeyUID=WOS:000273636500164.
  28. Briz, V.; Palladino, C.; Policarpo, S. N.; Silveira, L. F.; de Jose, I.; Gonzalez-Tome, I.; Moreno, D.; et al. "LONG-TERM (180 WEEKS) EFFICACY AND SAFETY OF FOSAMPRENAVIR IN HIV-INFECTED PAEDIATRIC PATIENTS IN CLINICAL PRACTICE". Child Care Health and Development 36 (2010): 76-76. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000273636500163&KeyUID=WOS:000273636500163.
  29. García-Alonso, D.; Palladino, C.; Bellón, J.M.; Resino, R.; Guillén, S.; Gurbindo, D.; De José, M.I.; et al. "An ecological analysis and the maternal profile of vertical HIV transmission in the Community of Madrid from 1980 until 2008,Análisis ecológico y perfil materno de la transmisión vertical del virus de la inmunodeficiencia humana en la Comunidad de Madrid desde 1980 hasta 2008". Acta Pediatrica Espanola 68 6 (2010): 292-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954974252&partnerID=MN8TOARS.
  30. García-Alonso, D.; Palladino, C.; María Bellón, J.; Resino, R.; Guillén, S.; Gurbindo, D.; De José, M.I.; et al. "A socio-economic and demographic analysis of the prevalence of paediatric HIV due to vertical transmission in the Community of Madrid,Análisis socioeconómico y demográfico de la prevalencia en niños infectados por el virus de la inmunodeficiencia humana por transmisión vertical en la Comunidad de Madrid". Acta Pediatrica Espanola 68 5 (2010): 235-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953846799&partnerID=MN8TOARS.
  31. Resino, S.; Palladino, C.; Lorente, R.; Micheloud, D.; Maria Bellón, J.; Larru, B.; Gutiérrez, M.D.G.; et al. "Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy". Pediatric Infectious Disease Journal 29 8 (2010): 774-777. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955175937&partnerID=MN8TOARS.
    10.1097/INF.0b013e3181db741b
  32. Palladino, C.; Briz, V.; Policarpo, S.N.; Silveira, L.F.; De José, M.I.; González-Tomé, M.I.; Moreno, D.; et al. "Long-term efficacy and safety of fosamprenavir in human immunodeficiency virus-infected pediatric patients". Pediatric Infectious Disease Journal 29 6 (2010): 563-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953149704&partnerID=MN8TOARS.
    10.1097/INF.0b013e3181d285ac
  33. Palladino, C.; Briz, V.; González-Tomé, M.I.; León Leal, J.A.; Navarro, M.L.; De José, M.I.; Ramos, J.T.; Muñoz-Fernández, M.A.. "Short communication: Evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials". AIDS Research and Human Retroviruses 26 3 (2010): 301-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950233376&partnerID=MN8TOARS.
    10.1089/aid.2009.0151
  34. Climent, F.; Palladino, C.; De Jose, I.; De Ory, S. J.; Bellon, J. M.; Guillen, S.; Gurbindo, D.; et al. "CAUSES OF DEATH IN HIV-1 VERTICALLY INFECTED PAEDIATRIC PATIENTS IN MADRID (SPAIN) FROM 1982 TO 2008". Child Care Health and Development 36 (2010): 46-46. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000273636500104&KeyUID=WOS:000273636500104.
  35. Palladino, C.; Bellón, J.M.; Jarrín, I.; Gurbindo, M.D.; De José, M.I.; Ramos, J.T.; González-Iome, M.I.; et al. "Impact of highly active antiretroviral therapy (HAART) on AIDS and death in a cohort of vertically HIV type 1-infected children: 1980-2006". AIDS Research and Human Retroviruses 25 11 (2009): 1091-1097. http://www.scopus.com/inward/record.url?eid=2-s2.0-71949129579&partnerID=MN8TOARS.
    10.1089/aid.2009.0070
  36. Palladino, C.; Bellón, J.M.; Perez-Hoyos, S.; Resino, R.; Guillén, S.; Garcia, D.; Gurbindo, M.D.; et al. "Spatial pattern of HIV-1 mother-to-child-transmission in Madrid (Spain) from 1980 till now: Demographic and socioeconomic factors". AIDS 22 16 (2008): 2199-2205. http://www.scopus.com/inward/record.url?eid=2-s2.0-55249088319&partnerID=MN8TOARS.
    10.1097/QAD.0b013e328310fa96
  37. Scavalli, C.P.S.; Mandelbrot, L.; Berrebi, A.; Batallan, A.; Cravello, L.; Pannier, E.; Hamrene, K.; et al. "Twin pregnancy as a risk factor for mother-to-child transmission of HIV-1: Trends over 20 years". AIDS 21 8 (2007): 993-1002. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247572894&partnerID=MN8TOARS.
    10.1097/QAD.0b013e3281532b19
  38. Paganotti, G.M.; Palladino, C.; Modiano, D.; Sirima, B.S.; Råberg, L.; Diarra, A.; Konaté, A.; et al. "Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso". Parasitology 132 5 (2006): 607-614. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646010337&partnerID=MN8TOARS.
    10.1017/S0031182005009601
Resumo em conferência
  1. Gonçalves, Paloma; Silvania Leal; Vitor Pimentel; Pingarilho, Marta; Moranguinho, Inês; Menilita Santos; Palladino, Claudia; et al. "Characterization of HIV-1 and HIV-2 genetic diversity and drug resistance profile in infected patients from Cape Verde". Trabalho apresentado em ASM Microbe 22, Washington, D.C., 2022.
    Aceite para publicação
  2. Martínez-Román P. "Impact of HCV coinfection in the splicing of HIV proviral DNA". Trabalho apresentado em 3rd HIV Research for Prevention (HIVR4P 2018), 2018.
    Publicado

Outros

Outra produção
  1. HAART and Causes of Death in Perinatally HIV-1-infected Children. Book chapter Palladino C, et al. Book ¿HIV and AIDS ¿ Updates on Biology, Immunology, Epidemiology and Treatment Strategies - Chapter 26. Editor Nancy Dumais. ISBN: 978-953-307-665-2, DOI: 10.5772/32695, InTech - Open Access Publisher (www.intechweb.org). 2011. Palladino, Claudia. http://www.intechopen.com/books/howtoreference/hiv-and-aids-updates-on-biology-immunology-epidemiology-and-treatment-strategies/haart-and-causes-of-death-in-perinatally-hiv-1-infected-children.