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Cristina Carvalho is presently a doctorate junior investigator, hired under FCT individual call for scientific employment 2017 (CEECIND/02201/2017). She graduated in Biology from the University of Coimbra (UC) in 2007 and in the same year she was qualified to attend the specialized master program in Cellular and Molecular Biology at the Faculty for Science and Technology of UC, program that she finished in 2008 with a score of 18 in 20 values. She applied to a PhD scholarship from the Portuguese Science Foundation (FCT), that she started in the beginning of 2009 where she worked under the supervision of Dr. Paula Moreira at FCTUC in the field of neurodegeneration with special focus in T2D-associated complications as risk factors for neurodegenerative events that could compromise brain homeostasis. Her Ph. D. project was performed in collaboration with Prof. David Busija form Tulane University, New Orleans where she performed a scientific internship for seven months. Cristina Carvalho obtained her Ph.D. degree in Cellular Biology from the University of Coimbra in 2013 with the highest score available: Suma cum laude. Between 2013 and 2015, she engaged in diverse projects, broadening her skills in Alzheimer's disease and Type 2 diabetes through various project fellowships. In 2015, Cristina was awarded a science management fellowship from the Faculty of Medicine, UC, enhancing her conceptual and procedural knowledge in different areas. Subsequently, in 2016, she received a national post-doc fellowship from FCT, allowing her to return to her primary interest, the study of diabetes-associated neurodegeneration. Presently, under the 2017 CEEC contract, Cristina is dedicated to exploring the mechanisms of Type 2 diabetes and its complications to identify potential therapeutic targets that may be used as preventive strategies against type 2 diabetes-induced complications. Although her CV exhibits a gap due to two maternity leaves and two sick leaves post-Ph.D. totalizing over 15 months, her contributions to science have been substantial since 2017. Indeed, she always remained involved in several projects and was responsible for several laboratory tutoring of master students (lab rotations and development of MSc work plans). More, she has authored over 30 papers and five book chapters, with 12 and four as the first author, respectively, since 2013. Notably, recent papers in high-impact factor journals (ARS with an IF=8.04 and Cellular and Molecular Life Sciences with an IF=9.2) and the Honorable Mention Pedro Eurico Lisboa/SPD from the Portuguese Society for Diabetology as result of her CEEC project, underscore her research excellence. In 2021, she was individually recognized as an Expertscape Expert in Alzheimer Disease by the Expertscape Recognition Program. Cristina's h-index of 33, >5000 citations, and accumulated IF of 194,702 demonstrate her impactful contributions. Her international recognition is evident through invitations to review papers and serve as a guest editor for 6 notable special issues in reputable journals, one of them standing in 2nd place in the Top 10 most successful Special Issues in 2022 of Biomedicines. Financially independent, she secured an ESCI EXPLORATORY RESEARCH GRANT and an FCT Exploratory research project, supporting her novel research path: exploring the impact of diabetes progression on brain function. Currently, Cristina has three papers under preparation for submission by year-end.
Identificação

Identificação pessoal

Nome completo
Cristina Carvalho

Nomes de citação

  • Carvalho, Cristina

Identificadores de autor

Ciência ID
621D-4A1A-D4A4
ORCID iD
0000-0001-5887-6417

Moradas

  • Rua Larga, Edf. Faculdade de Medicina POLO I, 1º Piso Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2022/11/14 - 2022/11/18
Concluído
VI Quantitative Fluorescence Microscopy Course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
approved
2021/10
Concluído
Insulin resistance Module 1: Insulin resistance, the metabolic syndrome and type 2 diabetes (Outros)
European Association for the Study of Diabetes, Alemanha
Aproved
2013/04/19 - 2013/04/30
Concluído
Course in Laboratory Animal Science training (previous cat. C) (Diploma de especialização)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Approved
2013
Concluído
Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer’s disease" (TESE/DISSERTAÇÃO)
Aprovado com Distinção e Louvor por Unanimidade
2008/08/30 - 2008/09/05
Frequentou
SFRR-E Free Radical Summer School (Outros)
Federation of European Biochemical Societies, Reino Unido
2008/07/07 - 2008/07/11
Concluído
Biology of Cell Death I: Apoptose Mechanism (Especialização pós-licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
Approved
2008
Concluído
Mestrado Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effects of metformin on mitochondrial bioenergetics and oxidative stress" (TESE/DISSERTAÇÃO)
18
2007
Concluído
Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Efeito da metformina na bioenergética mitocondrial" (TESE/DISSERTAÇÃO)
14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/04/01 - Atual Investigador Contratado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/03/01 - 2019/03/31 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
2015/06/01 - 2015/12/02 Gestão de Ciência e Tecnologia Universidade de Coimbra Faculdade de Medicina, Portugal
2014/08/01 - 2015/07/31 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/04/01 - 2014/07/31 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/01/05 - 2012/07/13 Investigador visitante (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
2011/01/05 - 2011/02/05 Investigador visitante (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
2008/06/01 - 2009/02/28 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2009/03/01 - 2013/02/28 PhD fellow (SFRH/BD/43965/2008) Fundação para a Ciência e a Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2016/03/01 - 2019/03/31 Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration
SFRH-BPD-107741-2015
SFRH/BPD/107741/2015
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2015 MITOCHONDRIAL TRAFFICKING IN ALZHEIMER’S DISEASE AND HYPOXIC PRECONDITIONING: UNVEILING THE ROLE OF THE HYPOXIA UP-REGULATED MITOCHONDRIAL MOVEMENT REGULATOR
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F841632%F2012/PT
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
Concluído
2012/05 - 2014/10 The impact of exendin-4 therapy in the molecular mechanisms underlying type 2 diabetes-related long-term brain dysfunction
PTDC/SAU-TOX/117481/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade da Beira Interior, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2013/04/01 - 2014/05/31 Genetic susceptibility of multisystemic complications of diabetes type 2: novel biomarkers for diagnosis and monitoring of therapy
Do-IT “DIAMARKER PROJECT”
Bolseiro de Integração na Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
PTDC/SAU-NEU/103325/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2009/03/01 - 2013/02/28 DIABETES-ASSOCIATED ENDOTHELIUM DYSFUNCTION: A CAUSE OF NEURODEGENERATION?THE ROLE OF BRAIN ENDOTHELIAL MITOCHONDRIA
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F439652%F2008/PT
SFRH/BD/43965/2008
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2019/04/01 - Atual CEECIND/2017 - WWOX and mitochondria: a dangerous relationship in type 2 diabetes-associated neurodegeneration
CEECIND/02201/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01 - 2023/06 Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2023 Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study
ESCI 2021
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Society for Clinical Investigation
Em curso
2018/07/26 - 2022/07/25 The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology
PTDC/MED-NEU/28214/2017
PTDC/MED-NEU/28214/2017
Investigador Pós-doutorado
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2013/08/31 Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease
PTDC/SAU-NMC/110990/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2016 - 2018 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
Premio Mantero Belard
Investigador Pós-doutorado
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em jornal
  1. Carvalho, Cristina. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista", Público, 2021
  2. Ramalho-Santos, João; Varela Amaral, Sara; Álvaro, Ana Rita ; Rego, Ana Cristina; Carvalho, Ana Luisa; Barros-Viegas, Ana Teresa; Cavadas, Claudia; et al. "Viagens sem Insónias", Jornal "O Público", 2018, http://www.cnbc.pt/docs/andrecaetano_layout_BD_SONO_2018__pt.pdf.
  3. Carvalho, Cristina. "Comic strip allusive to World Sleep Day entitled "Viagens sem insónias"", Jornal Publico, 2018
  4. Carvalho, Cristina. "Comic strip allusive to World Diabetes Day entitled "Viagens na diabetes"", Jornal Publico, 2017
Artigo em revista
  1. Cardoso, Susana; Carvalho, Cristina; Correia, Sónia C.. "Special Issue: “Alzheimer’s Disease—115 Years after Its Discovery”". Biomedicines 12 3 (2024): 478. http://dx.doi.org/10.3390/biomedicines12030478.
    Publicado • 10.3390/biomedicines12030478
  2. Carvalho, Cristina; Moreira, Paula I.. "Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria". Current Opinion in Neurobiology 79 (2023): 102694. http://dx.doi.org/10.1016/j.conb.2023.102694.
    10.1016/j.conb.2023.102694
  3. Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7.
    10.1007/s00018-022-04508-7
  4. Rodrigues-Neves, Ana Catarina; Carecho, Rafael; Correia, Sónia Catarina; Carvalho, Cristina; Campos, Elisa Julião; Baptista, Filipa Isabel; Moreira, Paula Isabel; Ambrósio, António Francisco. "Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer’s Disease". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02316-x.
    10.1007/s12035-021-02316-x
  5. Carvalho, Cristina; Cardoso, Susana. "Diabetes-Alzheimer´s disease link: Targeting mitochondrial dysfunction and redox imbalance". Antioxidants & Redox Signaling (2020): http://dx.doi.org/10.1089/ars.2020.8056.
    10.1089/ars.2020.8056
  6. Correia, S.C.; Carvalho, C.; Cardoso, S.; Moreira, P.I.. "Post-translational modifications in brain health and disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1865 8 (2019): 1947-1948. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065912707&partnerID=MN8TOARS.
    10.1016/j.bbadis.2019.05.006
  7. Candeias, E.; Sebastião, I.; Cardoso, S.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.; Duarte, A.I.. "Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats". Molecular Neurobiology 55 5 (2018): 4030-4050. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020070525&partnerID=MN8TOARS.
    10.1007/s12035-017-0622-3
  8. Carvalho, C.; Moreira, P.I.. "Oxidative stress: A major player in cerebrovascular alterations associated to neurodegenerative events". Frontiers in Physiology 9 JUL (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049844811&partnerID=MN8TOARS.
    10.3389/fphys.2018.00806
  9. Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al. "Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology". Molecular Neurobiology 54 8 (2017): 6471-6489. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS.
    10.1007/s12035-016-0155-1
  10. Plácido, A.I.; Pereira, C.M.F.; Correira, S.C.; Carvalho, C.; Oliveira, C.R.; Moreira, P.I.. "Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells". Molecular Neurobiology 54 1 (2017): 154-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953229269&partnerID=MN8TOARS.
    10.1007/s12035-015-9640-1
  11. Carvalho, Cristina. "Mitochondria in Alzheimer's Disease and Diabetes-Associated Neurodegeneration: License to Heal!". Handb Exp Pharmacol. (2017): https://www.ncbi.nlm.nih.gov/pubmed/28251365.
    10.1007/164_2017_3
  12. Carvalho, C.; Correia, S.C.; Perry, G.; Castellani, R.J.; Moreira, P.I.; Carvalho, Cristina. "Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview". Journal of Neural Transmission 123 2 (2016): 107-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957851903&partnerID=MN8TOARS.
    10.1007/s00702-015-1367-7
  13. Cardoso, S.; Carvalho, C.; Correia, S.C.; Seiça, R.M.; Moreira, P.I.. "Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine". Brain Pathology 26 5 (2016): 632-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988642816&partnerID=MN8TOARS.
    10.1111/bpa.12402
  14. Cristina Carvalho; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira. "Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852 8 (2015): 1665-1675. http://dx.doi.org/10.1016/j.bbadis.2015.05.001.
    10.1016/j.bbadis.2015.05.001
  15. Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I.. "The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases". Expert Review of Neurotherapeutics 15 8 (2015): 867-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS.
    10.1586/14737175.2015.1058160
  16. Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; et al. "Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?". CNS and Neurological Disorders - Drug Targets 14 4 (2015): 518-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS.
    10.2174/1871527314666150429112353
  17. Sena, C.M.; Pereira, A.M.; Carvalho, C.; Fernandes, R.; Seiça, R.M.; Oliveira, C.R.; Moreira, P.I.. "Type 2 diabetes aggravates alzheimer's disease-associated vascular alterations of the aorta in mice". Journal of Alzheimer's Disease 45 1 (2015): 127-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924181831&partnerID=MN8TOARS.
    10.3233/JAD-141008
  18. Carvalho, Cristina. "Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide.". World J Diabetes (2015): https://www.ncbi.nlm.nih.gov/pubmed/26131323.
    10.4239/wjd.v6.i6.807
  19. Carvalho, C.; Katz, P.S.; Dutta, S.; Katakam, P.V.G.; Moreira, P.I.; Busija, D.W.. "Increased susceptibility to amyloid-ß toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions". Journal of Alzheimer's Disease 38 1 (2014): 75-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887249119&partnerID=MN8TOARS.
    10.3233/JAD-130464
  20. Cardoso, S.; Correia, S.; Carvalho, C.; Candeias, E.; Plácido, A.I.; Duarte, A.I.; Seiça, R.M.; Moreira, P.I.; Carvalho, Cristina. "Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection". Journal of Bioenergetics and Biomembranes 47 1-2 (2014): 119-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922536968&partnerID=MN8TOARS.
    10.1007/s10863-014-9580-x
  21. Carvalho, C.; Correia, S.C.; Santos, M.S.; Baldeiras, I.; Oliveira, C.R.; Seiça, R.; Moreira, P.I.. "Vascular, oxidative, and synaptosomal abnormalities during aging and the progression of type 2 diabetes". Current Neurovascular Research 11 4 (2014): 330-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925786114&partnerID=MN8TOARS.
  22. Cardoso, S.; Carvalho, C.; Marinho, R.; Simões, A.; Sena, C.M.; Matafome, P.; Santos, M.S.; Seiça, R.M.; Moreira, P.I.. "Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status". Journal of Bioenergetics and Biomembranes 46 5 (2014): 347-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919396245&partnerID=MN8TOARS.
    10.1007/s10863-014-9551-2
  23. Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al. "The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 9 (2014): 1444-1453. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.05.003
  24. Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Seiça, R.; Santos, M.S.; Moreira, P.I.. "Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes". Molecular and Cellular Biochemistry (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901561690&partnerID=MN8TOARS.
    10.1007/s11010-014-2076-5
  25. Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.. "Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 7 (2014): 1154-1166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.04.011
  26. Cardoso S; Santos RX; Correia SC; Carvalho C; Santos MS; Baldeiras I; Oliveira CR; Moreira PI. "Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance.". (2013): http://europepmc.org/abstract/med/22940631.
    10.1016/j.nbd.2012.08.008
  27. Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al. "Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 4 (2013): 527-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.01.008
  28. Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies". Journal of Alzheimer's Disease 35 3 (2013): 623-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS.
    10.3233/JAD-130005
  29. Carvalho, Cristina. "Oxidative stress mediates apoptotic effects of ascorbate and dehydroascorbate in human Myelodysplasia cells in vitro". (2013): http://www.sciencedirect.com/science/article/pii/S0887233313000738.
    10.1016/j.tiv.2013.03.009
  30. Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I.. "Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an “Iffy” question!". Current Pharmaceutical Design 19 38 (2013): 6809-6822. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS.
  31. Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I.. "Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins". Current Molecular Medicine 13 4 (2013): 586-601. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS.
    10.2174/1566524011313040010
  32. Correia SC; Santos RX; Cardoso S; Carvalho C; Candeias E; Duarte AI; Plácido AI; Santos MS; Moreira PI. "Alzheimer disease as a vascular disorder: where do mitochondria fit?". (2012): http://europepmc.org/abstract/med/22824543.
    10.1016/j.exger.2012.07.006
  33. Carvalho C; Cardoso S; Correia SC; Santos RX; Santos MS; Baldeiras I; Oliveira CR; Moreira PI. "Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities.". (2012): http://europepmc.org/abstract/med/22427376.
    10.2337/db11-1186
  34. Correia SC; Santos RX; Carvalho C; Cardoso S; Candeias E; Santos MS; Oliveira CR; Moreira PI. "Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation.". (2012): http://europepmc.org/abstract/med/22290178.
    10.1016/j.brainres.2011.12.063
  35. Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I.. "The impairment of insulin signaling in Alzheimer's disease". IUBMB Life 64 12 (2012): 951-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS.
    10.1002/iub.1098
  36. Cardoso S; Carvalho C; Santos R; Correia S; Santos MS; Seiça R; Oliveira CR; Moreira PI. "Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters.". (2011): http://europepmc.org/abstract/med/20853444.
    10.1002/syn.20863
  37. Santos RX; Correia SC; Carvalho C; Cardoso S; Santos MS; Moreira PI. "Mitophagy in neurodegeneration: an opportunity for therapy?". (2011): http://europepmc.org/abstract/med/21269269.
    10.2174/138945011795528813
  38. Santos RX; Correia SC; Cardoso S; Carvalho C; Santos MS; Moreira PI. "Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease.". (2011): http://europepmc.org/abstract/med/21447003.
    10.1111/j.1471-4159.2011.07262.x
  39. Correia, S.C.; Cardoso, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Perry, G.; Smith, M.A.; Moreira, P.I.. "New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection". Current Pharmaceutical Design 17 31 (2011): 3381-3389. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055089996&partnerID=MN8TOARS.
    10.2174/138161211798072490
  40. Carvalho C; Santos MS; Baldeiras I; Oliveira CR; Seiça R; Moreira PI; Carvalho, C.; et al. "Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes.". Current Neurovascular Research 7 4 (2010): 288-300. http://europepmc.org/abstract/med/20854250.
    10.2174/156720210793180765
  41. Correia SC; Santos RX; Cardoso S; Carvalho C; Santos MS; Oliveira CR; Moreira PI; et al. "Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease?". Current Aging Science 3 2 (2010): 113-126. http://europepmc.org/abstract/med/20167003.
    10.2174/1874609811003020113
  42. Moreira PI; Carvalho C; Zhu X; Smith MA; Perry G. "Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology.". (2010): http://europepmc.org/abstract/med/19853658.
    10.1016/j.bbadis.2009.10.006
  43. Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al. "Mitochondrial preconditioning: A potential neuroprotective strategy". Frontiers in Aging Neuroscience 2 AUG (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955962818&partnerID=MN8TOARS.
    10.3389/fnagi.2010.00138
  44. Santos, R.X.; Cardoso, S.; Correia, S.; Carvalho, C.; Santos, M.S.; Moreira, P.I.; Santos RX; et al. "Targeting autophagy in the brain: A promising approach?". Central Nervous System Agents in Medicinal Chemistry 10 2 (2010): 158-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953681716&partnerID=MN8TOARS.
    10.2174/187152410791196350
  45. Cardoso S; Santos R; Correia S; Carvalho C; Zhu X; Lee H; Casadesus G; et al. "Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets.". Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular (2009): http://europepmc.org/abstract/PMC/PMC3978547.
  46. Carvalho C; Correia SC; Santos RX; Cardoso S; Moreira PI; Clark TA; Zhu X; Smith MA; Perry G. "Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.". (2009): http://europepmc.org/abstract/med/19830532.
    10.1007/s10863-009-9247-1
  47. Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al. "Food deprivation promotes oxidative imbalance in rat brain". Journal of Food Science 74 1 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS.
    10.1111/j.1750-3841.2008.00982.x
  48. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.; Oliveira, P.J.; Santos, M.S.; Moreira, P.I.. "Doxorubicin: The good, the bad and the ugly effect". Current Medicinal Chemistry 16 25 (2009): 3267-3285. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450215499&partnerID=MN8TOARS.
    10.2174/092986709788803312
  49. Cardoso, S.; Correia, S.; Santos, R.X.; Carvalho, C.; Santos, M.S.; Oliveira, C.R.; Perry, G.; et al. "Insulin is a two-edged knife on the brain". Journal of Alzheimer's Disease 18 3 (2009): 483-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249106915&partnerID=MN8TOARS.
  50. Correia S; Carvalho C; Santos MS; Seiça R; Oliveira CR; Moreira PI. "Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.". (2008): http://europepmc.org/abstract/med/18991752.
    10.2174/138955708786369546
  51. Cardoso S; Santos RX; Carvalho C; Correia S; Pereira GC; Pereira SS; Oliveira PJ; et al. "Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage.". (2008): http://europepmc.org/abstract/med/18775776.
    10.1016/j.freeradbiomed.2008.08.008
  52. Correia S; Carvalho C; Santos MS; Proença T; Nunes E; Duarte AI; Monteiro P; et al. "Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.". (2008): http://europepmc.org/abstract/med/18673148.
    10.2174/157340608784872299
  53. Carvalho C; Correia S; Santos MS; Seiça R; Oliveira CR; Moreira PI. "Metformin promotes isolated rat liver mitochondria impairment.". (2008): http://europepmc.org/abstract/med/17909944.
    10.1007/s11010-007-9614-3
  54. Cardoso, Susana; Santos, Renato X.; Carvalho, Cristina; Correia, Sónia; Pereira, Gonçalo C.; Pereira, Susana S.; Oliveira, Paulo J.; et al. "Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage". (2008): http://hdl.handle.net/10316/10086.
    https://doi.org/10.1016/j.freeradbiomed.2008.08.008
Capítulo de livro
  1. Carvalho, Cristina. "Disrupted cellular quality control mechanisms in aging". In Aging: From Fundamental Biology to Societal Impact. Elsevier, 2022.
    Aceite para publicação
  2. Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020.
    Publicado • 10.1007/978-3-030-53370-0_29
  3. Carvalho, C.; Cardoso, S.M.; Correia, S.C.; Moreira, P.I.. "Tortuous paths of insulin signaling and mitochondria in Alzheimer’s disease". 161-183. 2019.
    10.1007/978-981-13-3540-2_9
  4. Santos, Renato; Correia, Sónia; Cardoso, Susana; Carvalho, Cristina; Candeias, Emanuel; Plácido, Ana; Duarte, ANA; Santos, Maria; Moreira, Paula. "Role of Mitochondria and Oxidative Stress in Parkinson¿s Disease". In Role of Oxidative Stress in Chronic Diseases, 521-548. United States: CRC Press, 2014.
    Publicado • 10.1201/b16653-26
  5. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013.
    Publicado • 10.1002/9781118395318.ch5
  6. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013.
  7. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Association of mitochondrial signaling in Alzheimer's disease and hypoxia". 2011.
    Publicado • 10.2174/978160805092511101010050
  8. Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011.
    Publicado
  9. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011.
    Publicado
Edição de número de revista
  1. Cardoso, Susana; Carvalho, Cristina; Correia, Sónia. "Alzheimer's Disease¿115 Years after Its Discovery". Biomedicines (2021):
    No prelo
  2. Carvalho, Cristina. "Post-Translational Modifications in Brain Health and Disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2020): https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-basis-of-disease/vol/1865/issue/8.
    Publicado • Editor convidado
Poster em conferência
  1. Carvalho, Cristina; Paula I. Moreira. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects (1st author/presenter)". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes, 2021.
  2. Cristina Carvalho; Paula I. Moreira. "Wwox: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration". Trabalho apresentado em 18th WCIRDC Live Interactive Online Conference, 2020.
    10.1158/1538-7445.sabcs18-lb-085
  3. Carvalho, Cristina. "Mitochondrial ROS activate WWOX1 pathway under hyperglycemic conditions leading to neuronal death". Trabalho apresentado em MitoPorto- Advances in mitochondrial research, 2018.
  4. Carvalho, Cristina. "Mitochondrial biogenesis and autophagy dysfunction: Common features in Alzheimer's disease and type 2 diabetes-related brain alterations". Trabalho apresentado em MitoPorto- Advances in mitochondrial research, 2017.
  5. Carvalho, Cristina. "Adiponectin receptor in breast cancer: a mediator or a bystander?". Trabalho apresentado em VI Annual Meeting of IBILI, 2015., 2015.
  6. Carvalho, Cristina. "Brain mitochondrial, synaptic and autophagic dysfunction: coupled in Alzheimer’s disease and type 2 diabetes brain alterations". Trabalho apresentado em XIV Meeting of the Portuguese Neuroscience Society, 2015.
  7. Carvalho, Cristina. "Impact of high-fat diet and vitamin D deficiency in type 2 diabetic brains: a focus on hippocampal insulin signaling". Trabalho apresentado em XIV Meeting of the Portuguese Neuroscience Society, 2015.
  8. Duarte, Ana I.; Candeias, Emanuel Monteiro; Sebastiao, I.C.; Plácido, Ana I.; Santos, R.X.; Carvalho, Cristina; Correia, Sónia C.; et al. "Gender Influences Type 2 Diabetic-Related Intracellular Brain Signaling And Neurodegeneration Markers". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  9. Carvalho, Cristina. "Type 2 diabetic female rat brains are less vulnerable to oxidative stress and AD-related hallmarks: a role for insulin/IGF-1/estrogen signaling?". Trabalho apresentado em 9th FENS, Forum of European Neuroscience, 2014.
  10. Carvalho, Cristina. "Mitochondrial abnormalities as a mechanistic link in diabetes and Alzheimer disease interaction". Trabalho apresentado em FEBS Congress 2013, 2013.
  11. Zuo, Mingxin; Rashid, Asif; Churi, Chaitanya; Hung, Mien-Chie; Javle, Milind. "mTOR Pathway Mediates Diazoxide Preconditioning in Cultured Neurons". Trabalho apresentado em Experimental Biology 2013, 2013.
    10.1158/1535-7163.targ-13-c171
  12. Carvalho, Cristina. "Type 2 diabetic female rats are less vulnerable to alzheimer’s disease than males: the role of brain insulin/igf-1 and estrogen". Trabalho apresentado em 11th International Conference on Alzheimer's & Parkinson's Diseases, 2013.
  13. Carvalho, Cristina. "A mitocôndria como elo entre a diabetes tipo 2 e a doença de alzheimer". Trabalho apresentado em Annual meeting of the Portuguese Society of Diabetology, 2013.
  14. Carvalho, Cristina. "Type 2 diabetes-associated damage in aged rat brain: does gender matter?". Trabalho apresentado em 2nd Symposium of PF2MUC, Faculty of Medicine, 2012.
  15. Carvalho, Cristina. "Hyperglycemia increases brain endothelial cells susceptibility to ß-amyloid toxicity". Trabalho apresentado em Neuroscience 2012, 2012.
  16. Carvalho, Cristina. "Does gender influence age-related damage in type 2 diabetic rat brain?". Trabalho apresentado em 48th European Association for the Study of Diabetes Meeting 2012, 2012.
  17. Ito, Momoyo; Sato, Kazuhito; Fukumi, Minoru; Namura, Ikuro. "Triple transgenic Alzheimer's disease and sucrose-treated wild type mice present a similar pattern of brain mitochondrial dysfunction". Trabalho apresentado em XII Meeting of the Portuguese Society for Neurosciences, 2011.
    10.1109/nssmic.2011.6153731
  18. Carvalho, Cristina. "Metabolic alterations induced by sucrose intake and Alzheimer’s disease promote similar mitochondrial abnormalities". Trabalho apresentado em 10th International Conference on Alzheimer’s and Parkinson’s Diseases, 2011.
  19. Nesbitt, V; McFarland, R. "Sucrose-induced metabolic alterations lead to mitochondrial abnormalities similar to those found in 3xTg-AD mouse model of Alzheimer's disease". Trabalho apresentado em Models of dementia; the good, the bad and the future, 2010.
    10.1136/archdischild-2019-rcpch.251
  20. Carvalho, Cristina. "Mitochondrial dysfunction and oxidative status impairment: a comparative study between male and female 3xTg-AD mice". Trabalho apresentado em ICAD, Alzheimer´s Association International Conference on Alzheimer´s Disease, 2010.
  21. Jones, Robert B.; Dorsett, Kaitlyn A.; Hjelmeland, Anita B.; Bellis, Susan L.. "Hypoxia potentiates age-related oxidative imbalance in brain vessels". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, 2010.
  22. Carvalho, Cristina. "Insulin resistance induced by sucrose intake exacerbates brain mitochondrial dysfunction in a mouse model of Alzheimer's disease". Trabalho apresentado em ICAD, Alzheimer´s Association International Conference on Alzheimer´s Disease, 2010.
  23. Carvalho, Cristina. "Metformin attenuates type 2 diabetes-induced brain oxidative imbalance". Trabalho apresentado em XXIVth International Symposium on Cerebral Blood Flow, Metabolism, & Function, and the IXth International Conference on Quantification of Brain Function with PET, 2009.
  24. Carvalho, Cristina. "Effect of gender on brain mitochondria from the triple-transgenic mouse model of Alzheimer disease". Trabalho apresentado em Mitochondria: Between life and death, 2009.
  25. Carvalho, Cristina. "Doxorubicin increases the susceptibility of brain mitochondria to the Ca2+-induced permeability transition and oxidative damage". Trabalho apresentado em SFRR-E Free Radical Summer School “Lipid Peroxidation- and Free Radical-Signalling: Roles in Pathophysiology, 2008.
  26. Carvalho, Cristina. "Metformin attenuates diabetes-induced brain oxidative stress". Trabalho apresentado em SFRR-E Free Radical Summer School “Lipid Peroxidation- and Free Radical-Signalling: Roles in Pathophysiology, 2008.
  27. Carvalho, Cristina. "Metformin affects rat liver mitochondria". Trabalho apresentado em International Courses on Toxicology at the Centre for Neurosciences and Cell Biology, 2008.
  28. Carvalho, Cristina. "Brain mitochondria as a potential target of Doxorrubicin action". Trabalho apresentado em International Courses on Toxicology at the Centre for Neurosciences and Cell Biology, 2008.
Resumo em conferência
  1. Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Trabalho apresentado em 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021.
    Publicado
Tese / Dissertação
  1. Moreira, Paula; Santos, Maria; Carvalho, Cristina Isabel Marques Maurício de. "The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer’s disease". Doutoramento, 2013. http://hdl.handle.net/10316/23526.
  2. Carvalho, Cristina. "Effects of metformin on mitochondrial bioenergetics and oxidative stress". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2008.

Artística / Interpretação

Gravação vídeo
  1. Carvalho, Cristina. 2021. A Saúde no Saber: Um Mito Animado | 8th episode - "A demência é algo que só acontece à população idosa?". @ CNC media channel (Youtube).

Outros

Outra produção
  1. Guest-editor of the special issue: "Risk Factors for Neurodegenerative Diseases: Oxidative Stress Footprints as the Common Feature". 2022. Carvalho, Cristina. https://www.mdpi.com/journal/antioxidants/special_issues/465P317B30.
  2. Guest editor of Special Issue: Alzheimer's Disease - 115 Years after Its Discovery. Biomedicines journal (ISSN 2227-9059, Impact Factor 4.717). 2021. Carvalho, Cristina. https://www.mdpi.com/journal/biomedicines/special_issues/Alzheimer_115..
  3. Guest editor of Special Issue: Mitochondrial Dysfunction and Oxidative Stress in Diabetes and Associated Diseases. Antioxidants has received an increased Impact Factor of 5.014 in the latest edition of the Journal Citation Reports, published by Clarivate Analytics in June 2020. As such, Antioxidants ranks 10th out of 139 titles (Q1) in 'Food Science & Technology', 56rd out of 297 (Q1) in 'Biochemistry & Molecular Biology', and 7th out of 61 (Q1) in 'Medicinal Chemistry'. 2021. Carvalho, Cristina. https://www.mdpi.com/journal/antioxidants/special_issues/Oxidative_Stress_Diabetes.
  4. Guest editor of Special Issue: "State-of-the-Art Neurobiology and Neurologic Disease in Portugal". This Special Issue is intended to honor the pioneering achievements made by Portuguese physicians in the neurology field and to present the scientific developments in epidemiology, diagnosis, and treatment of neurologic diseases in Portugal.. 2021. Carvalho, Cristina. https://www.mdpi.com/journal/biomedicines/special_issues/neurobiology_Portugal.
  5. Guest editor of the special issue “Post-Translational Modifications in Brain Health and Disease” for Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018. Carvalho, Cristina. https://www.sciencedirect.com/journal/biochimica-et-biophysica-acta-bba-molecular-basis-of-disease/vol/1865/issue/8.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/01/29 Decoding the diabetic brain: Unveiling the Known and Unknown (Invited Speaker) IV Metabolism, Ageing and Disease (MAD) Meeting - Disease & Therapeutics: from the Past to Future
CIBB (Coimbra, Portugal)
2023/10/02 WWOX: the missing link in neurodegenerative-associated pathways in a mouse model of type 2 diabetes (presenter/senior author) 59th Annual Meeting of the European Association for the study of Diabetes
European Association for the Study of Diabetes (Hamburg, Alemanha)
2023/06/17 Brain mitochondrial function and oxidative stress normalized after WWOX inhibition in a mouse model of type 2 diabetes (1st author/invited speaker) 2nd International Alzheimers Disease & Dementia Conference
(Rome, Itália)
2023/06/07 WWOX inhibition by Zfra1-31: a new therapeutic approach against type 2 diabetes-associated brain damage (senior author/Presenter) 57th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (República Checa)
2023/03/16 O inibidor da WWOX Zfra1-31 melhora a função cognitiva e a disfunção das mitocôndrias de cérebros de ratinhos com diabetes tipo 2 (1st author/speaker)
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/01/25 WWOX: a new therapeutic target in Type 2 diabetes-associated neurodegeneration DCV talks
University of Coimbra (Coimbra, Portugal)
2022/11/12 WWOX inhibition by Zfra1-31 ameliorates brain mitochondrial dysfunction and oxidative stress in a mouse model of type 2 diabetes 2º Encontro Internacional da Sociedade Portuguesa de Fisiologia
Sociedade Portuguesa de Fisiologia (Coimbra, Portugal)
2022/06/09 Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study (1st author/speaker) 56th ESCI Annual Scientific Meeting (ASM)
European Society for Clinical Investigation (Bari, Itália)
2022/03/10 A inibição da proteína WWOX protege a mitocôndria e previne a morte de neurónios expostos a níveis elevados de glicose
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/09/28 Neuroprotective effect of Zfra 1-31 peptide against high glucose-induced mitochondrial dynamics and autophagy alterations. (1st author/speaker) 57th EASD Annual Meeting
European Society for the study of diabetes
2021/07/19 Zfra 1-31 prevents high glucose-induced neuronal death through improvement of mitochondrial and autophagy defects (invited speaker) International Conference on Diabetes and Endocrinology
coalesce research group
2021/06/09 WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death (1st author/speaker) 55th Annual Scientific Meeting - ESCI Virtual 2021
ESCI
2021/06/09 Ne-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells (1st author/speaker; flash talk) 55th Annual Scientific Meeting - ESCI Virtual 2021
ESCI
2020/03/06 WWOX na neurodegenerescência associada à diabetes: uma relação agridoce? (1st author/speaker) 16th Portuguese Diabetes Congress
Portuguese Society for diabetology (Vilamoura, Portugal)
2019/05/22 WWOX1 and mitochondria crosstalk in diabetic conditions: the beginning of a cell death fate (1st author/speaker) 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
(Coimbra, Portugal)
2013/07/03 Mitochondrial abnormalities as a mechanistic link in diabetes and Alzheimer disease interaction (1st author/speaker) 13th Young Scientists Forum
(San Petersburg, Rússia)
2013/05/30 Mitochondrial dysfunction in diabetes and Alzheimer’s disease: the missing link? (1st author/speaker) XIII meeting of the Portuguese Society for Neuroscience
(Luso, Portugal)
2013/04/17 Hyperglycemia-induced mitochondrial superoxide production potentiates ß-amyloid peptide toxicity in brain endothelial cells (1st author/speaker) 47th Annual Scientific Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2012/12/19 Exploring the similarities between Type 2 diabetes and Alzheimer disease (1st author/speaker/invited) X Annual Meeting Doctoral Programme in Experimental Biology and Biomedicine
(Coimbra, Portugal)
2012/11/03 Increased susceptibility to ß-amyloid toxicity in rat brain microvascular endothelial cells under hyperglycemic conditions (1st author) American Heart Association 2012
(Los Angeles, Estados Unidos)
2011/06/03 Metabolic alterations induced by sucrose intake induce Alzheimer’s disease-like behavioral and cognitive deficits and pathological alterations (1st author/speaker) 25th Meeting of GEECD
(Coimbra, Portugal)
2010/11/15 Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels (1st author/ invited speaker) Course of Biology of Aging, Doctoral Programme in Experimental Biology and Biomedicine
Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2010/06/25 Alzheimers disease and metabolic alterations induced by sucrose intake have a similar impact in brain mitochondrial bioenergetics (1st author/speaker) 24th Meeting of GEECD
(Coimbra, Portugal)
2008/05/05 Doxorubicin promotes ca2+-induced mitochondrial permeability transition and oxidative damage in brain mitochondria (co-author) International Courses on Toxicology “Mitochondria: Between life and death
Universidade de Coimbra centro de neurociências e Biologia Celular (Coimbra, Portugal)
2008/04/09 Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes (co-author) International Courses on Toxicology 2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2007/12/05 Metformin promotes isolated rat liver mitochondria impairment (1st author/speaker) XXXVIII Annual Reunion of Portuguese Society of Pharmacology, XX IV Reunion of Pharmacology clinic and VII Reunion of Toxicology,
(Coimbra, Portugal)
2007/12/05 Metformin counteracts the oxidative imbalance that occurs in the brain of diabetic Goto-Kakizaki rats (co-author) XXXVIII Annual Reunion of Portuguese Society of Pharmacology, XX IV Reunion of Pharmacology clinic and VII Reunion of Toxicology
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/09 - 2024/06 WWOX and cardiac complications in type 2 diabetes
Orientador
Integrated Master in Medicine (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10 - 2023/09 WWOX and cardiac complications in type 2 diabetes
Orientador
Integrated Master in Medicine (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01 - 2023/06 Avaliação de alterações celulares e moleculares no cérebro de modelos animais de diabetes tipo 2.
Orientador
Bioquímica (Iniciação científica)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/01 - 2023/06 AVALIAÇÃO DO POTENCIAL TERAPÊUTICO DO PEPTÍDEO ZFRA 1-31 NA LUTA CONTRA A NEURODEGENERAÇÃO ASSOCIADA À DIABETES TIPO 2
Orientador
Mestrado Integrado Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09 - 2023/01 Avaliação do potencial terapêutico do peptídeo zfa1-31 na luta contra a neurodegeneração associada à diabetes tipo 2.
Orientador
Medicina (Outra)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/06/27 - 2022/07/01 DISFUNÇÃO MITOCÔNDRIAL NO CÉREBRO EM MODELOS ANIMAIS DE DIABETES
Orientador
OCUPAÇÃO CIENTÍFICA DE JOVENS NAS FÉRIAS 2022 (Iniciação científica)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/02 - 2020/06/30 Alzheimer´s disease and Type 2 diabetes
Orientador
Biochemistry (Licenciatura/Bacharelato)
Universidade de Coimbra, Portugal
2019/01 - 2019/07 Ne-Carboxymethyl lysine induces mitochondrial dynamics alterations and autophagy disruption in differentiated SH-SY5Y neuroblastoma cells
Coorientador
Bioquímica (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/24 - 2017/08/04 ~Role of WWOX in type 2 diabetes-associated neurodegeneration
Orientador
Universidade de Coimbra Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022/12/15 - 2022/12/15 “Alzheimer’s Disease: The History of Forgetting”. Biomedicines webinar (2022/12/15 - 2022/12/15)
Seminário (Coorganizador)
Multidisciplinary Digital Publishing Institute AG, Suiça
2021/04 - 2021/11 Annual retreat of Metabolism, Aging and Disease Research area in Center for Neuroscience ann Celular Biology "Science out of the box" (2021/11/17 - 2021/11/18)
Encontro (Membro da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2009 International Courses on Toxicology “Mitochondria: between life and death” (2009 - 2009)
Congresso (Membro da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/10/27 - Atual Segredos escondidos da insulina: da Diabetes às doenças neurodegenerativas. 100 anos da insulina
Seminário
100 anos da insulina
Sociedade Portuguesa de Diabetologia, Portugal
2019 - Atual Brain Awareness Week - School visits
Outro
Brain awareness week
2008 - 2024 Brain Awareness Week
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/02/10 - 2023/02/11 2nd SYMPOSIUM ON ALZHEIMER'S DISEASE: an update on pathology and therapeutics.
Simpósio
2nd SYMPOSIUM ON ALZHEIMER'S DISEASE: an update on pathology and therapeutics.
Universidade do Porto, Portugal
2022/06/27 - 2022/07/01 Estágios de Verão para alunos do secundário. Ciência Viva
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2022 European Investigator night
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05/22 - 2018/05/22 Course on Gestão de Resíduos Hospitalares Perigosos – Triagem e Acondicionamento, organized by the CNC, Ambiwaste and AmbiPombal, May 22nd 2018. Duration: 90 min Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2018 Estágios de Verão para alunos do secundário
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014 Ciência Viva
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/04/21 - 2012/04/25 Participation in Experimental Biology, San Diego, California, U. S. A.
Congresso
Experimental Biology 2012
Tulane University Department of Pharmacology, Estados Unidos
2009/02/25 - 2009/02/27 Vascular Physiology
Outro
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/08/30 - 2008/09/05 Lipid Peroxidation- and Free Radical-Signalling: Roles in Pathophysiology” at SFRR-E Free Radical Summer School
Outro
Lipid Peroxidation- and Free Radical-Signalling: Roles in Pathophysiology
Federation of European Biochemical Societies, Reino Unido
2008/04/09 - 2008/04/11 Metabolic Toxicology: From Pathway to Organism
Outro
International Courses on Toxicology 2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/03/30 - 2007/04/02 XI National Meeting of Biology Students
Encontro
XI National Meeting of Biology Students
Universidade de Aveiro, Portugal
2007/03/21 - 2007/03/23 Stem Cells as a Toll in Toxicology
Outro
International Courses on Toxicology 2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/11/26 - 2006/11/26 Hemorreologia, microcirculation and oxidative stress
Conferência
XVI Reunion of Portuguese Society of Hemorreologia and microcirculation
Universidade de Coimbra, Portugal
2006/03/22 - 2006/03/24 Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy
Outro
International Courses on Toxicology 2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/03/07 - 2003/03/07 Toxicity: Notion of harmful
Conferência
Universidade de Coimbra, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2022/09/23 Autophagosome biogenesis and axonal transport dysfunction in Alzheimer's disease
Arguente principal
Alexandra Filipa Almeida Santos (Mestrado)
Universidade de Coimbra, Portugal
2021/07/23 Mitochondrial and redox-based transcriptional changes in type-2 diabetes mellitus and periodontitis
Arguente principal
Rita Baptista Sequeira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09 A cat problem: Characterization of feline spermatogonial stem cells
Arguente principal
Sara de Jesus Gomes Escada Rebelo (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Antioxidants and Redox Signaling (1523-0864) Mary Ann Liebert
2019 - Atual Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2018 - 2020 Neurochemistry International (0197-0186) Elsevier
2017 - 2020 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2017 - 2020 BIO-PROTOCOL (2331-8325) Bio-Protocol
2016 - 2020 Journal of Alzheimer s Disease (1875-8908) IOS Press
2019 - 2019 International Journal of Molecular Sciences (1422-0067) MDPI AG
2019 - 2019 Open Life Sciences (2391-5412) Walter de Gruyter GmbH
2016 - 2019 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2015 - 2019 Experimental Neurology (1090-2430) Elsevier
2018 - 2018 Evidence-based Complementary and Alternative Medicine (1741-4288) Hindawi Limited
2017 - 2018 Pathophysiology (0928-4680) Elsevier
2014 - 2018 BioMed Research International
2017 - 2017 Progress in Neuropsychopharmacology & Biological Psychiatry
2015 - 2016 Experimental Gerontology (0531-5565) Elsevier
2012 - 2016 Naunyn-Schmiedeberg s Archives of Pharmacology (1432-1912) Springer-Verlag
2015 - 2015 Journal of Neurology Neurological Science and Disorders (2641-2950) Peertechz Publications Private Limited
2015 - 2015 Journal of Geriatric Medicine and Gerontology (2469-5858) ClinMed International Library
2014 - 2015 Behavioural Neurology (1875-8584) Hindawi Limited
2014 - 2015 International Journal for Vitamin and Nutrition Research (1664-2821) Hogrefe Publishing Group
2011 - 2011 Cellular and Molecular Neurobiology (1573-6830) Springer-Verlag
2010 - 2010 Pharmaceuticals (1424-8247) MDPI AG

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2024/02 - 2024/02 ESF Grant Evaluation
Avaliador
European Science Foundation, França European Science Foundation
2023/06/26 - 2023/08 KAUST Opportunity Fund Program (OFP).
Avaliador
King Abdullah University of Science and Technology KAUST Solar Research Center, Arábia Saudita King Abdullah University of Science and Technology
2023/06 - 2023/07 Reviewer for the Standard projects for support of basic research, CZECH SCIENCE FOUNDATION
Avaliador
Grantová agentura Ceské republiky, República Checa
2019 - 2019 International reviewer of project proposal under the "Research Projects'' Call of The Croatian Science Foundation (HRZZ) .
Avaliador

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/02 - Atual Investigação Aplicada II Medicina (Licenciatura) Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01 - Atual Projecto Bioquimica Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/09 - 2023/01 Investigação Aplicada III Medicina (Licenciatura) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/04 - 2022/04 “Metabolic basis of AD” (invited speaker). Metabolic and Inflammatory Drivers in Age-Related Neurodegenerative Diseases. PHD Programme in Experimental Biology and Biomedicine (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/01 - 2020/02/01 Mitochondrial dysfunction in Alzheimer´s disease and Type 2 diabetes: A common target to have in mind! Pharmacology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2015 experimental advanced courses at Instituto de educação e cidadania: bio-medicine area: mitochondria and disease (Outros)

Membro de associação

Nome da associação Tipo de participação
2020 - Atual Sociedade Portuguesa de Diabetologia Membro
2018 - Atual European Society for Clinical Investigation Membro
2014 - Atual European Association for the Study of Diabetes Membro
1990 - Atual Corpo Nacional de Escutas Português -CNE Atual- Chefe de Unidade; Secretária de agrupamento; Membro do departamento do ambiente do Núcleo Mondego Sul

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2021/01 - Atual Editorial board member: Biomedicines
Membro
Multidisciplinary Digital Publishing Institute AG, Suiça

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018 - 2019/12 Qual o papel do HIF-1a nas alterações mitocondriais associadas à doença de Alzheimer? Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019/11 - 2019/11 Juri of Research Fellowship Applications under the project HealthyAging2020 (CENTRO-01-0145-FEDER-000012), BIM 2.2.2 – Processo 642855 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/22 - 2019/05/24 Revision of Abstracts/Poster Evaluation in Scientific Meetings Invited by the Organizing Committee of the 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI2019) (Coimbra, Portugal, May 22nd – 24th 2019) to be the president of the jury that evaluated poster communications presented at the Symposium 8 – Neurobiology of Aging for final prizes European Society for Clinical Investigation, Países Baixos
2019 - 2019 Research grant reviewer for Croatian Science Foundation
2018/11 - 2018/11 Juri of Research Fellowship Applications under the project HealthyAging2020 (CENTRO-01-0145-FEDER-000012), BIM 2.2.2 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 RECRUTAMENTO DE BOLSEIRO DE INVESTIGAÇÃO (MESTRE) BIM 2.2.2, NO ÂMBITO DO PROJETO IN0828 HealthyAging2020 | LUGUS 553026 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09 - 2017/09 Juri of Research Fellowship Applications under the project HealthyAging2020 (CENTRO-01-0145-FEDER-000012) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Tutoria

Tópico Nome do aluno
2022/10 - 2023/11 Caracterização de modelos animais de diabetes tipo 2. Muzakir Parkar
2023/07/01 - 2023/07/31 SCORE da IFMSA (International Federation of Medical Students' Associations) Meram Tawfik
2023/01 - 2023/02 T2D-associated metabolic alterations in brain Marta Mota
2022/06/27 - 2022/07/01 Ciência Viva: ocupação científica de jovens nas férias Laura Duarte
2022/07 - 2022/07 programa SCORE da IFMSA (International Federation of Medical Students' Associations Carmen Blanco Carrillo
2021/05 - 2021/07 Zfra1-31 peptide as a new approach against T2D Bernardo José Ribeiro Figueiredo
2018/09 - 2019/03 the role of Ne-Carboxymethyl lysine in diabetic neurodegeneration Victor Ferreira
2018/07/23 - 2018/08/03 Curtos Estágios Médicos em Férias - ANEM Augusto Henrique Ferreira Oliveira
2017/07 - 2017/09 WWOX1 and mitochondria crosstalk in diabetic conditions Henrique Santos
2017/07/07 - 2017/08/04 Curtos Estágios Médicos em Férias - ANEM Rita Figueiró
2016/10 - 2017/05/15 Role of WWOX in Type 2 diabetes-associated neurodegeneration Rute Tavares
2014 - 2015 Effect of Vitamin D insufficiency in diabetic brain: Focus in insulin signaling Guilherme Assis Loureiro
2013/01/04 - 2013/06/30 How Absence of vitamin D in a high fat diet can potentiate alterations in insulin signaling pathway Bárbara Marques
2010 - 2011 Effect of age and chronic hypoxia on oxidative status, mitochondria and apoptosis in rat liver Emanuel Candeias
Distinções

Prémio

2023 Honorable Mention Pedro Eurico Lisboa / SPD,
Sociedade Portuguesa de Diabetologia, Portugal
2021 ESCI EXPLORATORY RESEARCH GRANTS
European Society for Clinical Investigation, Países Baixos
2013 Young Scientists’ Forum 2013 Fellowship
2010 FENS/IBRO travel grant
FENS Information Ltd, Reino Unido

Título

2017 Junior Research contract level at CEEC 2017 individual call
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2023 Travel Grant for EASD 2023 participation
European Association for the Study of Diabetes, Alemanha
2023 Fundo Educacional SPD for participation in EASD 2023 congress
Sociedade Portuguesa de Diabetologia, Portugal
2021 Expertscape Expert in Alzheimer Disease