???global.info.a_carregar???
Rui M. Barbosa é professor associado da Faculdade de Farmácia (Laboratório de Métodos Analíticos e Bioanalíticos) da Universidade de Coimbra (FFUC), e investigador do Centro de Neurociências e Biologia Celular (CNC). Concluiu o Doutoramento em Ciências Farmacêuticas em 1998 pela FFUC. Tem lecionado principalmente as unidades curriculares de Métodos Instrumentais de Análise. Nos últimos anos tem centrado a sua investigação no design e desenvolvimento de sensores e biossensores para medições in vivo e ex vivo de marcadores neurometabólicos, neurotransmissores e neuromoduladores baseados em plataformas de microeléctrodos. É autor de mais de 70 artigos e revisões em revistas especializadas, contando 1800 citações e um fator h de 25. Foi orientador ou coorientador de 2 estudantes Pos-Doc, 6 de doutoramento e 2 de mestrado. Participou e foi também coordenador de vários projetos financiados. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica são: Pancreatic ß-cells; Bursting electrical activity; Pulsatile insulin release; Nitric oxide microsensor; Carbon nanotubes; In vivo electrochemistry; Neurodegeneration; Hippocampus; Microelectrode; Arrays Carbon fiber microelectrode, Biosensor.
Identificação

Identificação pessoal

Nome completo
Rui Manuel Silva Gomes Barbosa

Identificadores de autor

Ciência ID
5B16-6FC6-725F
ORCID iD
0000-0002-1604-6324

Endereços de correio eletrónico

  • rbarbosa@ff.uc.pt (Profissional)
  • rbarbosa@ci.uc.pt (Profissional)

Telefones

Telefone
  • 239488463 Ext.: 517614 (Profissional)

Moradas

  • Azinhaga de Santa Comba, Polo Ciências da Saúde- UC, 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • https://apps.uc.pt/mypage/pages/en (Académico)
  • www.uc.pt (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
Formação
Grau Classificação
1998
Concluído
Farmácia (Doutoramento)
Especialização em Química Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Mecanismos Iónicos Subjacentes À Secreção Pulsátil de Insulina pelo Ilhéu de Langerhans" (TESE/DISSERTAÇÃO)
1987/03/01 - 1990/01/01
Concluído
Provas de Aptidão Pedagógica e Capacidade Científica (Outros)
Especialização em Métodos Instrumentais de Análise
Universidade de Coimbra Faculdade de Farmácia, Portugal
1980/10/01 - 1986/07/31
Concluído
Ciências Farmacêuticas (Licenciatura)
Especialização em Especialização em Farmácia Industrial
Universidade de Coimbra Faculdade de Farmácia, Portugal
15.3
Percurso profissional

Docência no Ensino Superior

2017 - Atual Professor Associado (Docente Universitário)
Universidade de Coimbra, Portugal
1998/07/15 - 2017/03/23 Professor Auxiliar (Docente Universitário)
Universidade de Coimbra, Portugal

Cargos e Funções

2016 - 2018 Conselho geral ou orgão correspondente
Universidade de Coimbra, Portugal
2016 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente
Universidade de Coimbra, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Conselho de gestão ou orgão correspondente
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Conselho geral ou orgão correspondente
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Projeto

Designação Financiadores
2018 - 2021/07 Monitoring neurometabolic markers in vivo using microelectrode-based biosensors
POCI-01-0145-FEDER-28261
Fundação para a Ciência e a Tecnologia
2010 - 2013/10 Design of composite chemical sensors and biosensors for real-time and simultaneous monitoring of nitric oxide and oxygen in vivo in the brain.
Provided by PTCRIS: 103228
103228
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Ledo, A.; Lourenço, C.F.; Cadenas, E.; Barbosa, R.M.; Laranjinha, J.. "The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration". Free Radical Biology and Medicine 162 (2021): 500-513. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005.
    10.1016/j.freeradbiomed.2020.11.005
  2. Ledo, Ana; Fernandes, Eliana; Quintero, Jorge E.; Gerhardt, Greg A.; Barbosa, Rui M.. "Electrochemical Evaluation of a Multi-Site Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen". Micromachines 11 7 (2020): 632. http://dx.doi.org/10.3390/mi11070632.
    10.3390/mi11070632
  3. Ledo, Ana; Fernandes, Eliana; Brett, Christopher M.A.; Barbosa, Rui M.. "Enhanced selectivity and stability of ruthenium purple-modified carbon fiber microelectrodes for detection of hydrogen peroxide in brain tissue". Sensors and Actuators B: Chemical 311 (2020): 127899. http://dx.doi.org/10.1016/j.snb.2020.127899.
    10.1016/j.snb.2020.127899
  4. Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M.. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research 46 1 (2020): 64-76. http://dx.doi.org/10.1007/s11064-020-03015-0.
    10.1007/s11064-020-03015-0
  5. Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M.. "Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices". Bioelectrochemistry 130 (2019): 107325. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010.
    10.1016/j.bioelechem.2019.06.010
  6. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry". Current Opinion in Electrochemistry 12 (2018): 129-140. https://doi.org/10.1016/j.coelec.2018.05.018.
    10.1016/j.coelec.2018.05.018
  7. Nuno R. Ferreira; Ana Ledo; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays". Bioelectrochemistry 121 (2018): 142-150. https://doi.org/10.1016/j.bioelechem.2018.01.009.
    10.1016/j.bioelechem.2018.01.009
  8. Cândida Dias; Cátia F. Lourenço; Rui M. Barbosa; João Laranjinha; Ana Ledo. "Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices". Analytical Biochemistry 551 (2018): 43-50. https://doi.org/10.1016/j.ab.2018.05.010.
    10.1016/j.ab.2018.05.010
  9. Cátia F. Lourenço; Ana Ledo; Greg A. Gerhardt; João Laranjinha; Rui M. Barbosa. "Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays". Scientific Reports (2017): https://doi.org/10.1038/s41598-017-07119-6.
    10.1038/s41598-017-07119-6
  10. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa. "Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research". Analytical Chemistry (2017): https://doi.org/10.1021/acs.analchem.7b03452.
    10.1021/acs.analchem.7b03452
  11. Ana Ledo; Cátia F. Lourenço; João Laranjinha; Christopher M. A. Brett; Greg A. Gerhardt; Rui M. Barbosa. "Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue". Analytical Chemistry 89 3 (2017): 1674-1683. https://doi.org/10.1021/acs.analchem.6b03772.
    10.1021/acs.analchem.6b03772
  12. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)". Redox Biology 13 (2017): 94-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032301&partnerID=MN8TOARS.
    10.1016/j.redox.2017.05.007
  13. Nunes, C.; Almeida, L.; Barbosa, R.M.; Laranjinha, J.. "Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation". Food and Function 8 1 (2017): 387-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010953233&partnerID=MN8TOARS.
    10.1039/c6fo01529h
  14. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration". Free Radical Biology and Medicine 108 (2017): 668-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2017.04.026
  15. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling". Experimental Neurology 291 (2017): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.01.013
  16. Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation". Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.06.012
  17. Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain". Sensors and Actuators, B: Chemical 237 (2016): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS.
    10.1016/j.snb.2016.06.083
  18. Santos, R.M.; Laranjinha, J.; Barbosa, R.M.; Sirota, A.. "Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor". Biosensors and Bioelectronics 69 (2015): 83-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923082333&partnerID=MN8TOARS.
    10.1016/j.bios.2015.02.003
  19. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Cavaleiro, C.; Laranjinha, J.. "Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: Potential impact on gastric motility". Free Radical Biology and Medicine 82 (2015): 160-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925061584&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2015.01.021
  20. Pereira, C.; Barbosa, R.M.; Laranjinha, J.. "Dietary nitrite induces nitrosation of the gastric mucosa: The protective action of the mucus and the modulatory effect of red wine". Journal of Nutritional Biochemistry 26 5 (2015): 476-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928275461&partnerID=MN8TOARS.
    10.1016/j.jnutbio.2014.12.004
  21. Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay". Brain Research Bulletin 114 (2015): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925442099&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2015.03.002
  22. Lourenço, C.F.; Ledo, A.; Dias, C.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular and neurometabolic derailment in aging and alzheimer's disease". Frontiers in Aging Neuroscience 7 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84931266835&partnerID=MN8TOARS.
    10.3389/fnagi.2015.00103
  23. Santos, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Barbosa, R.M.. "Erratum: Evidence for a pathway that facilitates nitric oxide diffusion in the brain (Neurochem. Int. (2011) 59 (90-96) DOI: 10.1016/j.neuint.2011.05.016)". Neurochemistry International 91 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84951179683&partnerID=MN8TOARS.
    10.1016/j.neuint.2015.11.004
  24. Lourenço, C.F.; Ferreira, N.R.; Santos, R.M.; Lukacova, N.; Barbosa, R.M.; Laranjinha, J.. "The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum". Brain Research 1554 (2014): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895133025&partnerID=MN8TOARS.
    10.1016/j.brainres.2014.01.030
  25. Lourenço, C.F.; Santos, R.M.; Barbosa, R.M.; Cadenas, E.; Radi, R.; Laranjinha, J.. "Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide". Free Radical Biology and Medicine 73 (2014): 421-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903846214&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2014.05.021
  26. Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J.. "Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats". Cellular and Molecular Neurobiology 35 1 (2014): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921938863&partnerID=MN8TOARS.
    10.1007/s10571-014-0115-0
  27. Rocha, B.S.; Nunes, C.; Pereira, C.; Barbosa, R.M.; Laranjinha, J.. "A shortcut to wide-ranging biological actions of dietary polyphenols: Modulation of the nitrate-nitrite-nitric oxide pathway in the gut". Food and Function 5 8 (2014): 1646-1652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904984090&partnerID=MN8TOARS.
    10.1039/c4fo00124a
  28. Santos, Ricardo M.; Rodrigues, Marcelo S.; Laranjinha, João; Barbosa, Rui M.; Santos, R.M.; Rodrigues, M.S.; Laranjinha, J.; Barbosa, R.M.. "Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain". Biosensors and Bioelectronics 44 1 (2013): 152-159. http://hdl.handle.net/10316/26914.
    10.1016/j.bios.2013.01.015
  29. Figueiras, Edite; Oliveira, Ricardo; Lourenço, Cátia F; Campos, Rita; Humeau-Heurtier, Anne; Barbosa, Rui M; Laranjinha, João; et al. "Self-mixing microprobe for monitoring microvascular perfusion in rat brain". Medical and Biological Engineering and Computing 51 1-2 (2013): 103-112. http://hdl.handle.net/10316/80012.
    10.1007/s11517-012-0973-x
  30. Pereira, C.; Ferreira, N.R.; Rocha, B.S.; Barbosa, R.M.; Laranjinha, J.. "The redox interplay between nitrite and nitric oxide: From the gut to the brain". Redox Biology 1 1 (2013): 276-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879005609&partnerID=MN8TOARS.
    10.1016/j.redox.2013.04.004
  31. Ferreira, N.R.; Santos, R.M.; Laranjinha, J.; Barbosa, R.M.. "Real Time In Vivo Measurement of Ascorbate in the Brain Using Carbon Nanotube-Modified Microelectrodes". Electroanalysis 25 7 (2013): 1757-1763. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880348563&partnerID=MN8TOARS.
    10.1002/elan.201300053
  32. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Lundberg, J.O.; Mann, G.E.; Radi, R.; Laranjinha, J.. "Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins". Free Radical Biology and Medicine 58 (2013): 26-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875974388&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2012.12.017
  33. Nunes, C.; Ferreira, E.; Freitas, V.; Almeida, L.; Barbosa, R.M.; Laranjinha, J.. "Intestinal anti-inflammatory activity of red wine extract: Unveiling the mechanisms in colonic epithelial cells". Food and Function 4 3 (2013): 373-383. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874505366&partnerID=MN8TOARS.
    10.1039/c2fo30233k
  34. Oliveira, S.C.B.; Santarino, I.B.; Enache, T.A.; Nunes, C.; Laranjinha, J.; Barbosa, R.M.; Oliveira-Brett, A.M.. "Human colon adenocarcinoma HT-29 cell: Electrochemistry and nicotine stimulation". Bioelectrochemistry 94 (2013): 30-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879324150&partnerID=MN8TOARS.
    10.1016/j.bioelechem.2013.05.004
  35. Santos, R.M.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide inactivation mechanisms in the brain: Role in bioenergetics and neurodegeneration". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863706810&partnerID=MN8TOARS.
    10.1155/2012/391914
  36. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Lundberg, J.O.; Radi, R.; Laranjinha, J.. "Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling". Free Radical Biology and Medicine 52 3 (2012): 693-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856266699&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2011.11.011
  37. Simões, E.F.C.; Leitão, J.M.M.; Barbosa, R.M.; Esteves Da Silva, J.C.G.. "Flow injection analysis for nitric oxide quantification based on reduced fluoresceinamine". Analytical Methods 4 4 (2012): 1089-1097. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859339774&partnerID=MN8TOARS.
    10.1039/c2ay05774c
  38. Nunes, C.; Barbosa, R.M.; Almeida, L.; Laranjinha, J.. "Nitric oxide and DOPAC-induced cell death: From GSH depletion to mitochondrial energy crisis". Molecular and Cellular Neuroscience 48 1 (2011): 94-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960921750&partnerID=MN8TOARS.
    10.1016/j.mcn.2011.06.009
  39. LourençO, C.F.; Santos, R.; Barbosa, R.M.; Gerhardt, G.; Cadenas, E.; Laranjinha, J.. "In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus". Hippocampus 21 6 (2011): 622-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956360575&partnerID=MN8TOARS.
    10.1002/hipo.20774
  40. Santos, R.M.; Loureno, C.F.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Barbosa, R.M.. "Evidence for a pathway that facilitates nitric oxide diffusion in the brain". Neurochemistry International 59 1 (2011): 90-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960196903&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.05.016
  41. Rocha, B.S.; Gago, B.; Pereira, C.; Barbosa, R.M.; Bartesaghi, S.; Lundberg, J.O.; Radi, R.; Laranjinha, J.. "Dietary nitrite in nitric oxide biology: A redox interplay with implications for pathophysiology and therapeutics". Current Drug Targets 12 9 (2011): 1351-1363. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959998237&partnerID=MN8TOARS.
    10.2174/138945011796150334
  42. Santos, R.M.; Lourenço, C.F.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "Brain nitric oxide inactivation is governed by the vasculature". Antioxidants and Redox Signaling 14 6 (2011): 1011-1021. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951864475&partnerID=MN8TOARS.
    10.1089/ars.2010.3297
  43. Ledo, A.; Barbosa, R.; Cadenas, E.; Laranjinha, J.. "Dynamic and interacting profiles of .NO and O2 in rat hippocampal slices". Free Radical Biology and Medicine 48 8 (2010): 1044-1050. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950516684&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2010.01.024
  44. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Laranjinha, J.. "Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: Physiological impact". Nitric Oxide - Biology and Chemistry 22 3 (2010): 235-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-76949084897&partnerID=MN8TOARS.
    10.1016/j.niox.2010.01.003
  45. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Laranjinha, J.. "Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation". Toxicology 265 1-2 (2009): 41-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349876563&partnerID=MN8TOARS.
    10.1016/j.tox.2009.09.008
  46. Frade, J.G.; Barbosa, R.M.; Laranjinha, J.. "Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices". Hippocampus 19 7 (2009): 603-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649667029&partnerID=MN8TOARS.
    10.1002/hipo.20536
  47. Antunes, Célia M.; Rosário, Luís M.; Barbosa, Rui M.; Silva, Amélia S.; Baldeiras, Inês E.; Tomé, Ângelo R.; Santos, Rosa M.; et al. "Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in the absence of functional K-ATP channels". Endocrine Journal 55 4 (2008): 639-650. http://hdl.handle.net/10174/1525.
    10.1507/endocrj.K07E-131
  48. Gago, Bruno; Nyström, Thomas; Cavaleiro, Carlos; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João; Lundberg, Jon O.; et al. "The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions". Free Radical Biology and Medicine 45 4 (2008): 404-412. http://hdl.handle.net/10316/5829.
    10.1016/j.freeradbiomed.2008.04.027
  49. Lourenço, Cátia F.; Gago, Bruno; Barbosa, Rui M.; Freitas, Víctor de; Laranjinha, João. "LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion". (2008): http://hdl.handle.net/10316/10603.
  50. Frade, J.; Pope, S.; Schmidt, M.; Dringen, R.; Barbosa, R.; Pocock, J.; Laranjinha, J.; Heales, S.. "Glutamate induces release of glutathione from cultured rat astrocytes - A possible neuroprotective mechanism?". Journal of Neurochemistry 105 4 (2008): 1144-1152. http://www.scopus.com/inward/record.url?eid=2-s2.0-42549146494&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05216.x
  51. Santos, R.M.; Lourenço, C.F.; Piedade, A.P.; Andrews, R.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.. "A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue". Biosensors and Bioelectronics 24 4 (2008): 704-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049092283&partnerID=MN8TOARS.
    10.1016/j.bios.2008.06.034
  52. Castro, R. A. Esteves de; Canotilho, João; Barbosa, Rui M.; Silva, M. Ramos; Beja, A. Matos; Paixão, J. A.; Redinha, J. Simões. "Conformational Isomorphism of Organic Crystals: Racemic and Homochiral Atenolol". (2007): http://hdl.handle.net/10316/10572.
  53. de Castro, R.A.E.; Canotilho, J.; Barbosa, R.M.; Redinha, J.S.; Castro, R. A. Esteves de; Canotilho, João; Barbosa, Rui M.; Redinha, J. Simões. "Infrared spectroscopy of racemic and enantiomeric forms of atenolol". Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 67 5 (2007): 1194-1200. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347379327&partnerID=MN8TOARS.
    10.1016/j.saa.2006.10.007
  54. De Castro, R.A.E.; Canotilho, J.; Barbosa, R.M.; Silva, M.R.; Beja, A.M.; Paixão, J.A.; Redinha, J.S.. "Conformational isomorphism of organic crystals: Racemic and homochiral atenolol". Crystal Growth and Design 7 3 (2007): 496-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947521194&partnerID=MN8TOARS.
    10.1021/cg0601857
  55. Gago, B.; Lundberg, J.O.; Barbosa, R.M.; Laranjinha, J.. "Red wine-dependent reduction of nitrite to nitric oxide in the stomach". Free Radical Biology and Medicine 43 9 (2007): 1233-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548743996&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2007.06.007
  56. Ledo, A.; Frade, J.G.; Barbosa, R.M.; Laranjinha, J.. "Regulation of nitric oxide dynamics in hippocampus by NMDA and AMPA glutamate receptors". Current Topics in Pharmacology 10 2 (2006): 55-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149182950&partnerID=MN8TOARS.
  57. Ledo, Ana; Barbosa, Rui M.; Cadenas, Enrique; Gerhardt, Greg; Laranjinha, João. "Concentration Dynamics of Nitric Oxide in Rat Hippocampal Slices". (2005): http://hdl.handle.net/10316/9661.
  58. Frade, J.G.; Ferreira, N.R.; Barbosa, R.M.; Laranjinha, J.. "Mechanisms of neuroprotection by polyphenols". Current Medicinal Chemistry - Central Nervous System Agents 5 4 (2005): 307-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-28244468104&partnerID=MN8TOARS.
    10.2174/156801505774913062
  59. Diculescu, V.C.; Barbosa, R.M.; Oliveira Brett, A.M.. "In situ sensing of DNA damage by a nitric oxide-releasing compound". Analytical Letters 38 15 (2005): 2525-2540. http://www.scopus.com/inward/record.url?eid=2-s2.0-30744437404&partnerID=MN8TOARS.
    10.1080/00032710500369737
  60. Ferreira, N.R.; Ledo, A.; Frade, J.G.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.; Ferreira, Nuno R.; et al. "Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes". Analytica Chimica Acta 535 1-2 (2005): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744400539&partnerID=MN8TOARS.
    10.1016/j.aca.2004.12.017
  61. Ledo, A.; Barbosa, R.M.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Ledo, Ana; Barbosa, Rui M.; et al. "Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor". Proceedings of the National Academy of Sciences of the United States of America 102 48 (2005): 17483-17488. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444486330&partnerID=MN8TOARS.
    10.1073/pnas.0503624102
  62. Ledo, Ana; Frade, João; Barbosa, Rui M.; Laranjinha, João; Ledo, A.; Frade, J.; Barbosa, R.M.; Laranjinha, J.. "Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions". Molecular Aspects of Medicine 25 1-2 (2004): 75-89. http://hdl.handle.net/10316/5770.
    10.1016/j.mam.2004.02.010
  63. Pereira, F.C.; Ouedraogo, R.; Lebrun, P.; Barbosa, R.M.; Cunha, A.P.; Santos, R.M.; Rosário, L.M.. "Insulinotropic action of white lupine seeds (Lupinus albus L.): Effects of ion fluxes and insulin secretion from isolated pancreatic islets". Biomedical Research 22 2 (2001): 103-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-0009494765&partnerID=MN8TOARS.
  64. Baldeiras, Inês E.; Barbosa, Rui M.; Santos, Rosa M.; Rosário, Luís M.. "Involvement of protein kinase C in cholinergic potentiation of glucose-induced 5-HT/insulin secretion". (2000): http://hdl.handle.net/10316/3891.
  65. Barbosa, Rui M.; Silva, Amélia M.; Tomé, Angelo R.; Stamford, Jonathan A.; Santos, Rosa M.; Rosário, Luís M.; Barbosa, R.M.; et al. "Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics". Journal of Physiology 510 1 (1998): 135-143. http://hdl.handle.net/10316/8367.
    10.1111/j.1469-7793.1998.135bz.x
  66. Barbosa, R.M.; Silva, A.M.; Tome, A.R.; Stamford, J.A.; Santos, R.M.; Rosario, L.M.. "Erratum: Real time electrochemical detection of 5-HT/Insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization (Biochemical and Biophysical Research Communications (1996) 228 (100-104))". Biochemical and Biophysical Research Communications 231 2 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0030978941&partnerID=MN8TOARS.
  67. Barbosa, R.M.; Silva, A.M.; Tomé, A.R.; Stamford, J.A.; Santos, R.M.; Rosário, L.M.. "Real time electrochemical detection of 5-HT/insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization". Biochemical and Biophysical Research Communications 228 1 (1996): 100-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030297323&partnerID=MN8TOARS.
    10.1006/bbrc.1996.1622
  68. Barbosa, R.M.; Rosário, L.M.; Brett, C.M.A.; Oliveira Brett, A.M.. "Electrochemical studies of zinc in zinc-insulin solution". Analyst 121 12 (1996): 1789-1793. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030453233&partnerID=MN8TOARS.
    10.1039/an9962101789
  69. Castro, E.; Mateo, J.; Tomé, A.R.; Barbosa, R.M.; Miras-Portugal, M.T.; Rosário, L.M.. "Cell-specific purinergic receptors coupled to Ca2+ entry and Ca2+ release from internal stores in adrenal chromaffin cells: Differential sensitivity to UTP and Suramin". Journal of Biological Chemistry 270 10 (1995): 5098-5106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912175&partnerID=MN8TOARS.
  70. Barbosa, R.M.; Salgado, A.P.; Santos, R.M.; Rosário, L.M.. "Differential modulation of pancreatic ß-cell bursting by intracellular pH in the presence and absence of a K-ATP channel blocker". FEBS Letters 332 1-2 (1993): 9-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027436596&partnerID=MN8TOARS.
    10.1016/0014-5793(93)80471-6
  71. Rosário, L.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Abrunhosa, A.J.; Santos, R.M.. "Bursting electrical activity in pancreatic ß-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels". Pflügers Archiv European Journal of Physiology 424 5-6 (1993): 439-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027282069&partnerID=MN8TOARS.
    10.1007/BF00374906
  72. Santos, R.M.; Barbosa, R.M.; Silva, A.M.; Antunes, C.M.; Rosario, L.M.. "High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels". Biochemical and Biophysical Research Communications 187 2 (1992): 872-879. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026611726&partnerID=MN8TOARS.
    10.1016/0006-291X(92)91278-X
Livro
  1. Laranjinha, J.; Santos, R.M.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.. Nitric oxide signaling in the brain: Translation of dynamics into respiration control and neurovascular coupling. 2012.
    10.1111/j.1749-6632.2012.06582.x
  2. Ledo, A.; Barbosa, R.M.; Laranjinha, J.. Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices. 2012.
    10.1007/978-1-61779-382-0_5
  3. Barbosa, R.M.; Lourenço, C.F.; Santos, R.M.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.. Chapter 20 In Vivo Real-Time Measurement of Nitric Oxide in Anesthetized Rat Brain. 2008.
    10.1016/S0076-6879(08)01220-2
  4. Ledo, A.; Barbosa, R.M.; Frade, J.; Laranjinha, J.. Nitric oxide monitoring in hippocampal brain slices using electrochemical methods. 2002.
    10.1016/S0076-6879(02)59176-X
  5. Santos, R.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Salgado, A.P.; Abrunhosa, A.J.; Pereira, F.C.; Seiça, R.M.; Rosário, L.M.. Bursting electrical activity generated in the presence of KATP channel blockers: Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism. 1997.