| Artigo em revista |
- Reis, J.; Gaspar, A.; Milhazes, N.; Borges, F.. "Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances". Journal
of Medicinal Chemistry 60 19 (2017): 7941-7957. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031293351&partnerID=MN8TOARS.
10.1021/acs.jmedchem.6b01720
- Garrido, E.M.; Rodrigues, D.; Milhazes, N.; Borges, F.; Garrido, J.. "Molecular encapsulation of herbicide terbuthylazine
in native and modified ß-cyclodextrin". Journal of Chemistry 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018819102&partnerID=MN8TOARS.
10.1155/2017/8120367
- Baptista, S.; Lourenço, J.; Milhazes, N.; Borges, F.; Silva, A.P.; Bacci, A.. "Long-term treatment with low doses of methamphetamine
promotes neuronal differentiation and strengthens long-term potentiation of glutamatergic synapses onto dentate granule neurons".
eNeuro 3 3 (2016): 2413-2423. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010237500&partnerID=MN8TOARS.
10.1523/ENEURO.0141-16.2016
- Gaspar, A.; Milhazes, N.; Santana, L.; Uriarte, E.; Borges, F.; Matos, M.J.. "Oxidative stress and neurodegenerative diseases:
Looking for a therapeutic solution inspired on benzopyran chemistry". Current Topics in Medicinal Chemistry 15 5 (2015):
432-445. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930908241&partnerID=MN8TOARS.
- Baptista, Sofia; Lasgi, Charlène; Benstaali, Caroline; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Agasse, Fabienne;
et al. "Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate".
Stem Cell Research 13 2 (2014): 329-341. http://hdl.handle.net/10316/27821.
10.1016/j.scr.2014.08.003
- Almeida, Hugo Leite; Melo, António; Pêgo, José M.; Bernardo, Sara; Milhazes, Nuno; Borges, Fernanda; Sousa, Nuno; et al. "Variable
delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats". Frontiers in Behavioral Neuroscience
OCT (2013): http://hdl.handle.net/1822/26949.
10.3389/fnbeh.2013.00154
- Borges, F.; Reis, J.; Encarnação, I.; Gaspar, A.; Morales, A.; Milhazes, N.. "Parkinson's disease management. part iidiscovery
of mao-b inhibitors based on nitrogen heterocycles and analogues". Current Topics in Medicinal Chemistry 12 20 (2012):
2116-2130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874913282&partnerID=MN8TOARS.
- Reis, J.; Oliveira, C.; Milhazes, N.; Viña, D.; Borges, F.. "Exploring nitrostyrene as a scaffold for a new class a of monoamine
oxidase inhibitors". Letters in Drug Design and Discovery 9 10 (2012): 958-961. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870431026&partnerID=MN8TOARS.
10.2174/157018012804586888
- Gaspar, A.; Reis, J.; Fonseca, A.; Milhazes, N.; Viña, D.; Uriarte, E.; Borges, F.. "Chromone 3-phenylcarboxamides as potent
and selective MAO-B inhibitors". Bioorganic and Medicinal Chemistry Letters 21 2 (2011): 707-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651257725&partnerID=MN8TOARS.
10.1016/j.bmcl.2010.11.128
- Gaspar, A.; Teixeira, F.; Uriarte, E.; Milhazes, N.; Melo, A.; Cordeiro, M.N.D.S.; Ortuso, F.; Alcaro, S.; Borges, F.. "Towards
the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone
Amides". ChemMedChem 6 4 (2011): 628-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066953&partnerID=MN8TOARS.
10.1002/cmdc.201000452
- Martins, T.; Baptista, S.; Gonçalves, J.; Leal, E.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; et al. "Methamphetamine transiently
increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9".
Brain Research 1411 (2011): 28-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052037570&partnerID=MN8TOARS.
10.1016/j.brainres.2011.07.013
- Serafim, Teresa L.; Carvalho, Filipa S.; Marques, Maria P. M.; Calheiros, Rita; Silva, Tiago; Garrido, J.M.P.J.; Milhazes,
Nuno; et al. "Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells".
(2011): http://hdl.handle.net/10400.22/10235.
10.1021/tx200126r
- Garrido, E.M.P.J.; Garrido, J.M.P.J.; Milhazes, N.; Borges, F.; Oliveira-Brett, A.M.. "Electrochemical oxidation of amphetamine-like
drugs and application to electroanalysis of ecstasy in human serum". Bioelectrochemistry 79 1 (2010): 77-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951976659&partnerID=MN8TOARS.
10.1016/j.bioelechem.2009.12.002
- Stefano Alcaro; Alexandra Gaspar; Francesco Ortuso; Nuno Milhazes; Francisco Orallo; Eugenio Uriarte; Matilde Yáñez; et al.
"Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B". Bioorganic and Medicinal Chemistry
Letters 20 9 (2010): 2709-2712. https://repositorio-aberto.up.pt/handle/10216/96094.
10.1016/j.bmcl.2010.03.081
- Fernanda M. F. Roleira; Christophe Siquet; Elizabeta Orrù; E. Manuela Garrido; Jorge Garrido; Nuno Milhazes; Gianni Podda;
et al. "Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties".
Bioorganic and Medicinal Chemistry 18 16 (2010): 5816-5825. https://repositorio-aberto.up.pt/handle/10216/100809.
10.1016/j.bmc.2010.06.090
- goncalves, joana; baptista, sofia; martins, tania; milhazes, nuno; borges, fernanda; ribeiro, carlos f.; malva, joao o.; et
al. "Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin".
European Journal of Neuroscience 31 2 (2010): 315-326. https://repositorio-aberto.up.pt/handle/10216/91224.
10.1111/j.1460-9568.2009.07059.x
- Reis, B.; Martins, M.; Barreto, B.; Milhazes, N.; Garrido, E.M.; Silva, P.; Garrido, J.; Borges, F.. "Structure-property-activity
relationship of phenolic acids and derivatives. Protocatechuic acid alkyl esters". Journal of Agricultural and Food Chemistry
58 11 (2010): 6986-6993. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953145782&partnerID=MN8TOARS.
10.1021/jf100569j
- Gaspar, A.; Garrido, E.M.; Esteves, M.; Quezada, E.; Milhazes, N.; Garrido, J.; Borges, F.. "New insights into the antioxidant
activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives". European
Journal of Medicinal Chemistry 44 5 (2009): 2092-2099. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749186901&partnerID=MN8TOARS.
10.1016/j.ejmech.2008.10.027
- Calheiros, R.; Machado, N.F.L.; Fiuza, S.M.; Gaspar, A.; Garrido, J.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Antioxidant
phenolic esters with potential anticancer activity: A Raman spectroscopy study". Journal of Raman Spectroscopy 39 1
(2008): 95-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549148538&partnerID=MN8TOARS.
10.1002/jrs.1822
- Milhazes, N.; Martins, P.; Uriarte, E.; Garrido, J.; Calheiros, R.; Marques, M.P.M.; Borges, F.; et al. "Electrochemical and
spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine
(MDMA) and its synthetic precursors". Analytica Chimica Acta 596 2 (2007): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447260978&partnerID=MN8TOARS.
10.1016/j.aca.2007.06.027
- Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Grade, S.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R.. "Methamphetamine
induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory". Neuroscience
150 2 (2007): 433-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749024725&partnerID=MN8TOARS.
10.1016/j.neuroscience.2007.09.044
- Gulaboski, R.; Cordeiro, M.N.D.S.; Milhazes, N.; Garrido, J.; Borges, F.; Jorge, M.; Pereira, C.M.; et al. "Evaluation of
the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface
between two immiscible solutions". Analytical Biochemistry 361 2 (2007): 236-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846486983&partnerID=MN8TOARS.
10.1016/j.ab.2006.11.006
- Milhazes, N.; Cunha-Oliveira, T.; Martins, P.; Garrido, J.; Oliveira, C.; Rego, A.C.; Borges, F.. "Synthesis and cytotoxic
profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity
relationship". Chemical Research in Toxicology 19 10 (2006): 1294-1304. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750209029&partnerID=MN8TOARS.
10.1021/tx060123i
- Milhazes, Nuno; Calheiros, Rita; Marques, M. Paula M.; Garrido, Jorge; Cordeiro, M. Natália D. S.; Rodrigues, Cátia; Quinteira,
Sandra; et al. "ß-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study".
Bioorganic and Medicinal Chemistry 14 12 (2006): 4078-4088. http://hdl.handle.net/10316/45140.
10.1016/j.bmc.2006.02.006
- Borges, F.; Roleira, F.; Milhazes, N.; Santana, L.; Uriarte, E.. "Simple coumarins and analogues in medicinal chemistry: Occurrence,
synthesis and biological activity". Current Medicinal Chemistry 12 8 (2005): 887-916. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944389028&partnerID=MN8TOARS.
10.2174/0929867053507315
- Calheiros, R.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "ß-Nitrostyrene derivatives - A conformational study by combined
Raman spectroscopy and ab initio MO calculations". Journal of Molecular Structure 692 1-3 (2004): 91-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842612527&partnerID=MN8TOARS.
10.1016/j.molstruc.2004.01.012
- Carvalho, M.; Remião, F.; Milhazes, N.; Borges, F.; Fernandes, E.; Do Céu Monteiro, M.; Gonçalves, M.J.; et al. "Metabolism
is required for the expression of ecstasy-induced cardiotoxicity in vitro". Chemical Research in Toxicology 17 5 (2004):
623-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442639021&partnerID=MN8TOARS.
10.1021/tx049960f
- Carvalho, M.; Milhazes, N.; Remião, F.; Borges, F.; Fernandes, E.; Amado, F.; Monks, T.J.; Carvalho, F.; Bastos, M.L.. "Hepatotoxicity
of 3,4-methylenedioxyamphetamine and a-methyldopamine in isolated rat hepatocytes: Formation of glutathione conjugates". Archives
of Toxicology 78 1 (2004): 16-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-1442278713&partnerID=MN8TOARS.
10.1007/s00204-003-0510-7
- Carvalho, M.; Remião, F.; Milhazes, N.; Borges, F.; Fernandes, E.; Carvalho, F.; Bastos, M.L.. "The toxicity of N-methyl-a-methyldopamine
to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine". Toxicology 200 2-3 (2004):
193-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942714874&partnerID=MN8TOARS.
10.1016/j.tox.2004.03.016
- Fiuza, S.M.; Van Besien, E.; Milhazes, N.; Borges, F.; Marques, M.P.M.. "Conformational analysis of a trihydroxylated derivative
of cinnamic acid - A combined Raman spectroscopy and Ab initio study". Journal of Molecular Structure 693 1-3 (2004):
103-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942422260&partnerID=MN8TOARS.
10.1016/j.molstruc.2004.02.019
- Fiuza, S.M.; Gomes, C.; Teixeira, L.J.; Girão Da Cruz, M.T.; Cordeiro, M.N.D.S.; Milhazes, N.; Borges, F.; Marques, M.P.M..
"Phenolic acid derivatives with potential anticancer properties - A structure-activity relationship study. Part 1: Methyl,
propyl and octyl esters of caffeic and gallic acids". Bioorganic and Medicinal Chemistry 12 13 (2004): 3581-3589. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942612898&partnerID=MN8TOARS.
10.1016/j.bmc.2004.04.026
- Santana, L.; Uriarte, E.; Roleira, F.; Milhazes, N.; Borges, F.. "Furocoumarins in medicinal chemistry. Synthesis, natural
occurrence and biological activity". Current Medicinal Chemistry 11 24 (2004): 3239-3261. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844219683&partnerID=MN8TOARS.
- Milhazes, Nuno; Borges, Fernanda; Calheiros, Rita; Marques, M. Paula M.; Milhazes, N.; Borges, F.; Calheiros, R.; Marques,
M.P.M.. "Identification of synthetic precursors of amphetamine-like drugs using Raman spectroscopy and ab initio calculations:
beta-Methyl-beta-nitrostyrene derivatives". Analyst 129 11 (2004): 1106-1117. http://hdl.handle.net/10316/45149.
10.1039/b405290k
- Remião, F.; Milhazes, N.; Borges, F.; Carvalho, F.; Bastos, M.L.; Lemos-Amado, F.; Domingues, P.; Ferrer-Correia, A.. "Synthesis
and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood". Biomedical Chromatography
17 1 (2003): 6-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037281216&partnerID=MN8TOARS.
10.1002/bmc.203
- Gomes, Catarina A.; Cruz, Teresa Girão da; Andrade, José L.; Milhazes, Nuno; Borges, Fernanda; Marques, M. Paula M.; Gomes,
C.A.; et al. "Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin: A Structure-Activity Study". Journal
of Medicinal Chemistry 46 25 (2003): 5395-5401. http://hdl.handle.net/10316/45155.
10.1021/jm030956v
- Carvalho, M.; Hawksworth, G.; Milhazes, N.; Borges, F.; Monks, T.J.; Fernandes, E.; Carvalho, F.; et al. "Role of metabolites
in MDMA (ecstasy)-induced nephrotoxicity: An in vitro study using rat and human renal proximal tubular cells". Archives
of Toxicology 76 10 (2002): 581-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036390214&partnerID=MN8TOARS.
10.1007/s00204-002-0381-3
- Lemos-Amado, F.; Domingues, P.; Ferrer-Correia, A.; Remião, F.; Milhazes, N.; Borges, F.; Carvalho, F.D.; Bastos, M.L.. "Electrospray
tandem mass spectrometry of aminochromes". Rapid Communications in Mass Spectrometry 15 24 (2001): 2466-2471. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035543079&partnerID=MN8TOARS.
10.1002/rcm.498
|
