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Luís Pereira de Almeida has been working since 1998 in gene/molecular therapy approaches for the Central Nervous System. In 2002 published one of the first papers showing that lentiviral vectors can be used to produce in vivo models of neurodegenerative diseases (e.g. Huntington's, Parkinson's, Machado-Joseph's disease), an approach on which his group specialized and that is now extensively used in the field (de Almeida LP et al The Journal of Neuroscience 2002). Professor at the Faculty of Pharmacy, University of Coimbra since 2003, coordinated the Masters in Pharmaceutical Biotechnology and the Doctoral Programme in Experimental Biology and Biomedicine, and teaches at graduate and undergraduate levels. His research activity is developed at CNC - Center for Neuroscience and Cell Biology of the University of Coimbra (Group Leader and President), and CIBB - Center for Innovative Biomedicine and Biotechnology (Coordinator). He spent short sabbatical leaves at CEA, Saclay in France (2005) and at the Massachussetts Institute of Technology (2010). The research of his group has been focused on molecular approaches for the study of the molecular mechanisms and advanced therapies for neurodegenerative disorders with a focus on Machado-Joseph disease/spinocerebellar ataxia type 3, including disease modifying and gene silencing approaches, autophagy activation and proteolysis inhibition, sirtuin-1 activation, etc, works published in over 100 papers and book chapters cited over thirteen thousand times, in journals such as Brain (5), Nature Communications, Cell Metabolism, Cell Reports, Acta Neuropathologica, Annals of Neurology, Human Molecular Genetics (6), Scientific Reports, PlosOne, awarded with prizes by Janssen Pharmaceutics, the Portuguese Society for Neurosciences (2009, 2011, 2012, 2013), the Portuguese Society of Human Genetics (2009), and Fundação Pulido Valente. Luis Pereira de Almeida has mentored 12 pos doctoral fellows and >20 PhD students and is or has been responsible for over 30 research projects funded by the Portuguese Foundation for Science and Technology, the Association Française de Myopathies, private funds, the National Ataxia Foundation (USA), the Center Region of Portugal and led one of the twelve European research groups that constitute the Marie Curie Initial Training Network “TreatPolyQ” within the 7th Framework Program of the European Union. His group integrates(ed) an iMi (EU Innovative Medicines Initiative) Project (Accelerating Research and Development in Advanced Therapies - ARDAT), an E-rare Eranet and 3 JPND european network projects, 2 of these - SynSpread and ModelPolyQ under his coordination. Bibliometric indicators: Publications: Books and book chapters : 9; Peer-reviewed papers: >100; Other: 43; Total 145; Publications Q1: 85%; Publications in Top 10%: 21; Conferences by invitation: >200; Communications in conferences by abstract submission: >300; PhD Thesis Commitees: 72; Principal opponent: 25; Citation Number (Google scholar): 13,000; h-index (Google scholar): 46; Atracted funding as PI: > 5 000 000; Evaluation by University of Coimbra (Research, Teaching, Technology transfer, University Management): (2014-2016) - Excelent. (2011-2013) - Excelent. Supervised 17 pos doctoral fellows, Supervised >20 PhD Students.
Identificação

Identificação pessoal

Nome completo
LUÍS FERNANDO MORGADO PEREIRA DE ALMEIDA

Nomes de citação

  • Pereira de Almeida, Luis
  • de Almeida, L
  • Almeida, L
  • Pereira de Almeida, L

Identificadores de autor

Ciência ID
5911-1D34-FB6B
ORCID iD
0000-0001-5831-3307
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=uQzosFsAAAAJ
Researcher Id
A-4605-2009
Scopus Author Id
7005988619

Endereços de correio eletrónico

  • luispa@cnc.uc.pt (Profissional)
  • luispa@ci.uc.pt (Profissional)
  • luispa@ff.uc.pt (Profissional)

Moradas

  • University of Coimbra | Center for Neuroscience and Cell Biology | Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Clínica - Neurologia Clínica
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Outras Ciências Médicas
  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2003/02/21
Concluído
Farmácia (Doutoramento)
Especialização em Tecnologia Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Lentiviral-based Modeling and gene therapy of Huntington's disease " (TESE/DISSERTAÇÃO)
1997 - 2003
Concluído
Doutoramento em Tecnologia Farmacêutica (Doutoramento)
Universidade de Coimbra, Portugal
"Lentiviral-based gene delivery approaches for functional and therapeutic studies in Huntington’s disease" (TESE/DISSERTAÇÃO)
Distinção e Louvor
2003
Concluído
Farmácia (Doutoramento)
Especialização em Especialidade: Tecnologia Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Lentiviral-based Gene Delivery Approaches for Therapeutic and Functional Studies in Huntington´s Disease" (TESE/DISSERTAÇÃO)
1996/01/30
Concluído
Tecnologias do Medicamento (Mestrado)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Farmácia, Portugal
1993 - 1996
Concluído
Mestrado em Tecnologias do Medicamento (Mestrado)
Universidade de Coimbra, Portugal
"Modelização da cinética de dissolução de fármacos pouco solúveis em sistemas multiparticulares" (TESE/DISSERTAÇÃO)
Muito Bom
1991/06
Concluído
Ciências Farmacêuticas (Licenciatura)
Especialização em Farmácia Industrial
Universidade de Coimbra Faculdade de Farmácia, Portugal
1985 - 1991
Concluído
Licenciatura em Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019 - Atual Investigador Coordenador (carreira) (Investigação) CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory, Portugal
CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory, Portugal
1998/01/01 - 2001/04/03 Estagiário de Investigação (Investigação) Centre Hospitalier Universitaire Vaudois, Suiça

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2020/06 - Atual Professor Associado (Docente Universitário) University of Coimbra, Faculty of Pharmacy, Portugal
2003/02/22 - 2020 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2019 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
2016 - 2018 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
2003/02 - 2008/02 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
1996/01 - 2003/02 Assistente (Docente Universitário) Universidade de Coimbra, Portugal
1998/02 - 2001/04 Assistente (Docente Universitário) Universite de Lausanne, Suiça
1993/03 - 1996/01 Assistente Estagiário (Docente Universitário) Universidade de Coimbra, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2020/10/01 - Atual President of CNC Universidade de Coimbra, Portugal
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2014/07/01 - 2020/10/01 Vice-Presidente Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2019 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2017 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra Faculdade de Farmácia, Portugal
1991/09/01 - 1993/05/31 Dirigente de laboratório, instituto, museu, centro ou observatório Laboratórios Delta - Rotta Research Group , Portugal
Laboratórios Delta - Rotta Research Group , Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2008/02/22 - Atual Nomeação definitiva | Tenure Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2021/01/01 - Atual Accelerating Research & Development for Advanced Therapies (ARDAT)
Innovative Health Initiative, Bélgica
European Union

European Federation of Pharmaceutical Industries and Associations

European Commission
Em curso
2013 - Atual Viravector - Infrastructure of the national roadmap for production and research with viral vectors
CENTRO-01-0145-FEDER-022095
Investigador responsável
2024/01 - 2029/12 GeneT - The Gene Therapy CoE at the Center of Portugal
Investigador responsável
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
European Commission
Em curso
2023/09/01 - 2026/08/31 NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)
JPND/0001/2022
Universidade de Coimbra, Portugal

CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory, Portugal

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/01/01 - 2025/12/31 CInTech: Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Quadro de Referência Estratégico Nacional (QREN)
2020/11/01 - 2025/10/31 ARDAT - Accelerating research & development for advanced therapies- Innovative Medicines Initiative. EU Grant agreement number 945473. WP3 Co-lead.
945473
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
EU Framework Programme for Research and Innovation Societal Challenges
Em curso
2023/03/01 - 2024/08/31 Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/03/01 - 2024/08/31 From “bedside-to-bench” biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease
2022.06118.PTDC
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/03/01 - 2024/08/31 Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 – towards the understanding of the neuroprotective mechanism
2022.04788.PTDC
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/02/01 - 2024/07/31 Exploring mitophagy to rescue neurological syndromes in mitochondrial diseases
2022.04458.PTDC
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/03/01 - 2024/02/29 Assessing aging of human neurons by direct induced neuronal iN conversion
PTDC/MED-NEU/3890/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/07/01 - 2023/06/30 MJDedit - Sistemas de edição génica para o gene ATXN3: Uma terapia para a doença de Machado-Joseph
CENTRO-01-0145-FEDER-181266
Universidade de Coimbra, Portugal
Autoridade de Gestão do Programa Operacional CENTRO2020
Concluído
2022/01/01 - 2023/06/30 Genome editing to rescue Machado-Joseph disease by alternative splicing
EXPL/MED-NEU/0936/2021
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2020/10/01 - 2023/06/30 ReSet - Development of a food supplement based on Resveratrol for optimal CNS activity
CENTRO-01-0247-FEDER-070162
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
2020/08/01 - 2023/06/30 Fighting Sars-CoV-2 with Viral Vectors
CENTRO-01-01D2-FEDER-000002
Investigador responsável
Universidade de Coimbra, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluído
2018/07/26 - 2022/07/25 The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology
PTDC/MED-NEU/28214/2017
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2022/06/30 Blocking neurodegeneration by spreading of gene silencers
PTDC/BTM-SAL/29716/2017
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/06/15 - 2022/06/14 The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease.
PTDC/BTM-ORG/30737/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/10/13 - 2022/04/12 The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy
PTDC/MED-NEU/29480/2017
Universidade do Algarve, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/06 - 2022/04/05 Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy
PTDC/MED-NEU/32309/2017
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017/03/01 - 2022/03/31 ViraVerctor - Viral Vectors for Gene Transfer Core Facility
PINFRA/22095/2016
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/12/31 NiNjA - New Neuroendocrine Strategy for healthy Aging.
PTDC/MED-FAR/30167/2017
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/01/07 - 2021/06/30 SpreadSilencing - Neurodegeneration blocking by genetic silencers dispersion, FCT-Portuguese Foundation for Science and Technology. POCI-01-0145-FEDER-029716. Principal investigator
POCI-01-0145-FEDER-029716
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2017/01/01 - 2021/06/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/04/01 - 2020/03/31 Advanced models of polyglutamine disorders
JPCOFUND/0005/2015
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/12/31 Imaging Gene Therapy in the Brain
PTDC/BBB-NAN/0932/2014
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/04/01 - 2019/12/31 Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Control of cardiomyocyte proliferation in disease and regenerative medicine
PTDC/BIM-MED/3363/2014
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

iNOVA4Health, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/09 - 2019/09 JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Medical Research Council

Fundação para a Ciência e a Tecnologia
Concluído
2017/04/01 - 2019/06/30 NanoBiomateriais poliméricos para libertação de fármacos: Desenvolvimento e implementação co conceito "safe-by-design" permitindo soluções seguras em cuidados de saúde
ProSafe/0001/2016
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/03/01 - 2018/12/31 Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases
JPND-CD/0001/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2018/12 Gene repair and repression strategies to alleviate Machado-Joseph disease Fundação para a Ciência e a Tecnologia
2013/03 - 2016/12 Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration
Provided by PTCRIS: 132829PRJ
Fundação para a Ciência e a Tecnologia
2013/03 - 2016/02 Towards the Understanding of Pathological Protein Processing and Toxicity in Machado-Joseph Disease.
E-Rare4/0003/2012
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Research Area Board
Concluído
2013 - 2016 Caffeine alleviation of MJD/SCA3
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
National Ataxia Foundation
Concluído
2014/03/01 - 2015/09/30 Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo
EIT-KIC/IVE/0043/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/03 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing Fundação para a Ciência e a Tecnologia
2012/01/24 - 2015/07/30 Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells
PTDC/SAU-NMC/116512/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/04 - 2015/03 Non-invasive-Non-viral Silencing of Machado-Joseph disease
PTDC/SAU-FAR/116535/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2011/03 - 2015/02 TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases European Commission
2011/04/01 - 2014/09/30 Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?
PTDC/SAU-NMC/109955/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04/01 - 2013/07/15 Caloric restriction increases lifespan: role of neuropeptide Y on autophagy
PTDC/SAU-FCF/099082/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/04/30 The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
PTDC/SAU-NEU/099307/2008
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2010/12 - 2012/12 Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease.
SB/NF/2010/2008 Number 15079CA
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
AFM-Téléthon
Concluído
2010/03/18 - 2012/02/29 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
PTDC/SAU-NEU/108668/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/07 - 2010/12 Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3
PTDC/SAU-FCF/70384/2006
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2005/09/01 - 2008/08/31 Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs
POCI/SAU-MMO/56055/2004
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2005/09 - 2008/08 Transcription regulation by FK506 and BDNF control mitochondrial dependent cell death - a protective role in Huntington's disease
Provided by PTCRIS: 57310PRJ
POCI/SAU-NEU/57310/2004
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
1998/02/01 - 2001/03/31 SISTEMAS POLIMÉRICOS CONTENDO FACTORES NEUROTRÓFICOS PARA TERAPIA DE DOENÇA NEURODEGENERATIVA
PRAXIS XXI/BD/9469/96
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021 - Atual Protoloco CNC e Exogenus Therapeutics
NA
2020 - Atual Collaboration agreement - F. Hoffmann - La Roche Ltd (Roche Group)
NA
CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
F Hoffmann-La Roche AG Research and Development Division

F Hoffmann-La Roche AG
2018 - Atual Wave Life Sciences - Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
NA
Wave Life Sciences
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2024/12/31 Center for Innovative Biomedicine and Biotechnology
UIDP/04539/2020
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2024/12/31 Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2023 miRSilencing
NA
PTC Therapeutics Inc
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2019 Calpain inhibition as a therapeutic strategy in Machado-Joseph disease.
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Blade Therapeutics, Inc
Concluído
2018 - 2019 uniQure - REF. Collaboration agreement_uniQure biopharma B.V.
Collaboration agreement_uniQure biopharma B.V
CIBB - Center for Innovative Biomedicine and Biotecnology - Associated Laboratory, Portugal

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
uniQure biopharma BV
Em curso
2015/01/01 - 2017/12/31 CNC.IBILI
UID/NEU/04539/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2016 Cabaletta@CNC
NA
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Bioblast Pharma
Concluído
2013/01/01 - 2014/12/14 Strategic Project LA 1 2013-2014
PEstC/ SAU/LA0001/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Coelho, Patricia; Fão, Lígia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Peça, João; Rego, Ana Cristina Carvalho. "Impact of SAPAP3 on mitochondrial function in Huntingtons disease". 2021.
    Publicado
  2. Lobo, Diana; Nobre, Rui Jorge; Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; et al. "Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
    10.3389/conf.fncel.2019.01.00022
  3. Nobre, Rui; Saraiva, Joana; Paixão, Susana; Fusco, Cellia; Santana, Magda; Miranda, Catarina; Petrella, Lorena; et al. "Non-invasive and allele-specific silencing therapy for Polyglutamine disorders: the case of Machado-Joseph disease/Spinocerebellar ataxia type 3". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
    Publicado • 10.3389/conf.fncel.2019.01.00007
Artigo em jornal
  1. Ramalho-Santos, João; Varela Amaral, Sara; Correia, Marta Quatorze; Cardoso, João; Pereira de Almeida, Luis; André Caetano; Ana Catarina Vinhas; et al. "Uma Viagem Rara", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Artigo em revista
  1. Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira. "Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-53542-x.
    10.1038/s41598-024-53542-x
  2. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luís; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules 259 (2024): 129157. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157.
    10.1016/j.ijbiomac.2023.129157
  3. Henriques, Carina; Lopes, Miguel M; Silva, Ana C; Lobo, Diana D; Aron Badin, Romina; Hantraye, Philippe; Pereira de Almeida, Luís; Nobre, Rui Jorge. "Viral-based animal models in polyglutamine disorders". Brain (2024): http://dx.doi.org/10.1093/brain/awae012.
    10.1093/brain/awae012
  4. Soares Martins, Tânia; Pelech, Steven; Ferreira, Maria; Pinho, Beatriz; Leandro, Kevin; de Almeida, Luís Pereira; Breitling, Benedict; et al. "Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer’s Disease". International Journal of Molecular Sciences 25 3 (2024): 1584. http://dx.doi.org/10.3390/ijms25031584.
    10.3390/ijms25031584
  5. Weber, Niklas; Buchholz, Maresa; Rädke, Anika; Faber, Jennifer; Schmitz-Hübsch, Tanja; Jacobi, Heike; Klockgether, Thomas; et al. "Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia". The Cerebellum (2024): http://dx.doi.org/10.1007/s12311-024-01657-2.
    10.1007/s12311-024-01657-2
  6. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. Autor correspondente: Nobre, Rui Jorge. "Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol". JoVE Journal e66550 (2024): https://www.jove.com/t/66550.
    No prelo
  7. Hengel, Holger; Martus, Peter; Faber, Jennifer; Giunti, Paola; Garcia-Moreno, Hector; Solanky, Nita; Klockgether, Thomas; et al. "Correction to: The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors". Journal of Neurology 271 1 (2023): 628-629. http://dx.doi.org/10.1007/s00415-023-12064-8.
    10.1007/s00415-023-12064-8
  8. Mariana Martins; Ana Rafaela Oliveira; Solange Martins; José Pedro Vieira; Pedro Perdigão; Ana Rita Fernandes; Luís Pereira de Almeida; et al. "A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612603.
    10.3390/ijms241612603
  9. Patrícia Pereira; Ana S. Neto; Ana S. Rodrigues; Inês Barros; Catarina Miranda; João Ramalho-Santos; Luís Pereira de Almeida; et al. "In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration". Polymers (2023): https://doi.org/10.3390/polym15102256.
    10.3390/polym15102256
  10. Maria Soares; Maria M. Pinto; Rui Jorge Nobre; Luís Pereira de Almeida; Maria da Graça Rasteiro; Teresa Almeida-Santos; João Ramalho-Santos; Ana Paula Sousa. "Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation". Biomolecules (2023): https://doi.org/10.3390/biom13020278.
    10.3390/biom13020278
  11. Carmo-Silva, S.; Ferreira-Marques, M.; Nóbrega, C.; Botelho, M.; Costa, D.; Aveleira, C.A.; Pulst, S.M.; et al. "Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes". Journal of Molecular Endocrinology 70 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85143645604&partnerID=MN8TOARS.
    Em revisão • 10.1530/JME-21-0272
  12. Klockgether, T.; Synofzik, M.; Alhusaini, S.; Anheim, M.; Antonijevic, I.; Ashizawa, T.; Bataller, L.; et al. "Consensus Recommendations for Clinical Outcome Assessments and Registry Development in Ataxias: Ataxia Global Initiative (AGI) Working Group Expert Guidance". Cerebellum (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85151668891&partnerID=MN8TOARS.
    10.1007/s12311-023-01547-z
  13. Rufino-Ramos, D.; Albuquerque, P.R.; Leandro, K.; Carmona, V.; Martins, I.M.; Fernandes, R.; Henriques, C.; et al. "Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3". Molecular Therapy 31 5 (2023): 1275-1292. http://www.scopus.com/inward/record.url?eid=2-s2.0-85154619372&partnerID=MN8TOARS.
    10.1016/j.ymthe.2023.04.001
  14. Uebachs, M.; Wegner, P.; Schaaf, S.; Kugai, S.; Jacobi, H.; Kuo, S.-H.; Ashizawa, T.; et al. "SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias". Cerebellum (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85151467845&partnerID=MN8TOARS.
    10.1007/s12311-023-01546-0
  15. Santana, M.M.; Gaspar, L.S.; Pinto, M.M.; Silva, P.; Adão, D.; Pereira, D.; Ribeiro, J.A.; et al. "A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia". Neuropathology and Applied Neurobiology 49 2 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85153765323&partnerID=MN8TOARS.
    10.1111/nan.12892
  16. Ferreira-Marques, M.; Carvalho, A.; Franco, A.C.; Leal, A.; Botelho, M.; Carmo-Silva, S.; Águas, R.; et al. "Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome". Aging Cell (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85174420928&partnerID=MN8TOARS.
    10.1111/acel.13983
  17. Raposo, M.; Hübener-Schmid, J.; Ferreira, A.F.; Vieira Melo, A.R.; Vasconcelos, J.; Pires, P.; Kay, T.; et al. "Blood transcriptome sequencing identifies biomarkers able to track disease stages in spinocerebellar ataxia type 3". Brain 146 10 (2023): 4132-4143. http://www.scopus.com/inward/record.url?eid=2-s2.0-85173781207&partnerID=MN8TOARS.
    10.1093/brain/awad128
  18. Koppenol, R.; Conceição, A.; Afonso, I.T.; Afonso-Reis, R.; Costa, R.G.; Tomé, S.; Teixeira, D.; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain 146 6 (2023): 2346-2363. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160404450&partnerID=MN8TOARS.
    10.1093/brain/awac473
  19. Arnaut, Z.A.; Pinto, S.M.A.; Aroso, R.T.; Amorim, A.S.; Lobo, C.S.; Schaberle, F.A.; Pereira, D.; et al. "Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers". Photochemical and Photobiological Sciences (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85172998540&partnerID=MN8TOARS.
    10.1007/s43630-023-00476-4
  20. Hengel, H.; Martus, P.; Faber, J.; Giunit, P.; Garcia-Moreno, H.; Solanky, N.; Klockgether, T.; et al. "The frequency of non-motor symptoms in SCA3 and their association with disease severity and lifestyle factors". Journal of Neurology 270 2 (2023): 944-952. http://www.scopus.com/inward/record.url?eid=2-s2.0-85141199384&partnerID=MN8TOARS.
    10.1007/s00415-022-11441-z
  21. Rufino-Ramos, David; Leandro, K; Perdigão, Pedro; O'Brien, K; Pinto, MM; Santana, MM; van Solinge, TS; et al. "Extracellular communication between brain cells through functional transfer of Cre mRNA". Molecular Therapy (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85160280091&partnerID=MN8TOARS.
    No prelo • 10.1016/j.ymthe.2023.05.012
  22. Miguel M. Lopes; Jacques Paysan; José Rino; Sara M. Lopes; Luís Pereira de Almeida; Luísa Cortes; Rui Jorge Nobre. "A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification". Gene Therapy (2022): https://doi.org/10.1038/s41434-022-00372-z.
    10.1038/s41434-022-00372-z
  23. Rodrigo F. N. Ribeiro; Dina Pereira; Luis Pereira de Almeida; Maria Manuel C. Silva; Cláudia Cavadas. "SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders". Aging Clinical and Experimental Research (2022): https://doi.org/10.1007/s40520-022-02257-y.
    10.1007/s40520-022-02257-y
  24. Roderick P.P.W.M. Maas; Steven Teerenstra; Manuela Lima; Paula Pires; Luís Pereira de Almeida; Judith van Gaalen; Dagmar Timmann; et al. "Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3". Movement Disorders (2022): https://doi.org/10.1002/mds.29135.
    10.1002/mds.29135
  25. Hector Garcia-Moreno; Mercedes Prudencio; Gilbert Thomas-Black; Nita Solanky; Karen R. Jansen-West; Rana Hanna AL-Shaikh; Amanda Heslegrave; et al. "Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3". European Journal of Neurology (2022): https://doi.org/10.1111/ene.15373.
    10.1111/ene.15373
  26. Helena Leal; João Cardoso; Patrícia Valério; Marta Quatorze; Vítor Carmona; Janete Cunha-Santos; Luís Pereira de Almeida; et al. "SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway". International Journal of Molecular Sciences 23 12 (2022): 6790-6790. https://doi.org/10.3390/ijms23126790.
    10.3390/ijms23126790
  27. Koen Breyne; Stefano Ughetto; David Rufino-Ramos; Shadi Mahjoum; Emily A. Grandell; Luís P. de Almeida; Xandra O. Breakefield. "Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins". Communications Biology (2022): https://doi.org/10.1038/s42003-022-03440-7.
    10.1038/s42003-022-03440-7
  28. Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto Rolim Muro Martinez; Marcondes Cavalcante França Jr; Clévio Nóbrega; et al. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology (2022): https://doi.org/10.1111/nan.12763.
    10.1111/nan.12763
  29. Holger Hengel; Peter Martus; Jennifer Faber; Hector Garcia-Moreno; Nita Solanky; Paola Giunti; Thomas Klockgether; et al. "Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity". Movement Disorders (2022): https://doi.org/10.1002/mds.28844.
    10.1002/mds.28844
  30. Ana Teresa Simões; Vítor Carmona; Joana Duarte-Neves; Janete Cunha-Santos; Luís Pereira de Almeida. "Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado–Joseph disease| Spinocerebellar ataxia type 3". Neuropathology and Applied Neurobiology (2022): https://doi.org/10.1111/nan.12748.
    10.1111/nan.12748
  31. Vasconcelos-Ferreira, A.; Martins, I.M.; Lobo, D.; Pereira, D.; Lopes, M.M.; Faro, R.; Lopes, S.M.; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy 30 1 (2022): 370-387. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115030983&partnerID=MN8TOARS.
    10.1016/j.ymthe.2021.07.012
  32. Rufino-Ramos, D.; Lule, S.; Mahjoum, S.; Ughetto, S.; Cristopher Bragg, D.; Pereira de Almeida, L.; Breakefield, X.O.; Breyne, K.. "Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo". Biomaterials 281 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85122652441&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2022.121366
  33. Nobre, R.J.; Lobo, D.D.; Henriques, C.; Duarte, S.P.; Lopes, S.M.; Silva, A.C.; Lopes, M.M.; et al. "MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics 32 3 (2022): 194-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-85129129262&partnerID=MN8TOARS.
    10.1089/nat.2021.0020
  34. Miranda, C.O.; Nobre, R.J.; Paiva, V.H.; Duarte, J.V.; Castelhano, J.; Petrella, L.I.; Sereno, J.; et al. "Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease". Acta Neuropathologica Communications 10 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85126741777&partnerID=MN8TOARS.
    10.1186/s40478-022-01329-4
  35. Lobo, C.S.; Rodrigues-Santos, P.; Pereira, D.; Núñez, J.; Trêpa, J.C.D.; Sousa, D.L.; Lourenço, J.V.; et al. "Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation". Photochemical and Photobiological Sciences (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85126514875&partnerID=MN8TOARS.
    10.1007/s43630-022-00202-6
  36. Almeida, S.F.F.; Fonseca, A.; Sereno, J.; Ferreira, H.R.S.; Lapo-Pais, M.; Martins-Marques, T.; Rodrigues, T.; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small 18 49 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141363010&partnerID=MN8TOARS.
    10.1002/smll.202203999
  37. Brás, J.; Henriques, D.; Moreira, R.; Santana, M.M.; Silva-Pedrosa, R.; Adão, D.; Braz, S.; et al. "Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases". Scientific Reports 12 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134499812&partnerID=MN8TOARS.
    10.1038/s41598-022-16369-y
  38. Quintino, L.; Almeida, L.P.D.; Lundberg, C.. "Editorial: Gene therapy 2.0: Biotechnology for circuit engineering and complex therapeutic approaches". Frontiers in Bioengineering and Biotechnology 10 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85143363515&partnerID=MN8TOARS.
    10.3389/fbioe.2022.1082883
  39. Carmo-Silva, Sara; Ferreira-Marques, Marisa; Nóbrega, Clévio David Rodrigues ; Botelho, Mariana; Costa, Daniela G.; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Deciphering a new role for Ataxin-2 in the hypothalamus: linking metabolism and circadian rhythm regulation.". Molecular Endocrinology (2022):
    Em revisão
  40. Ana S. Neto; Patrícia Pereira; Ana C. Fonseca; Carla Dias; Mariana C. Almeida; Inês Barros; Catarina O. Miranda; et al. "Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair". Polymers (2021): https://doi.org/10.3390/polym13244378.
    10.3390/polym13244378
  41. Shadi Mahjoum; David Rufino-Ramos; Luís Pereira de Almeida; Marike L. D. Broekman; Xandra O. Breakefield; Thomas S. van Solinge; Mahjoum, Shadi; et al. "Living Proof of Activity of Extracellular Vesicles in the Central Nervous System". International Journal of Molecular Sciences 22 14 (2021): 7294-7294. https://doi.org/10.3390/ijms22147294.
    10.3390/ijms22147294
  42. Barros, I.; Silva, A.; de Almeida, L.P.; Miranda, C.O.. "Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy". Cytokine and Growth Factor Reviews (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85098642605&partnerID=MN8TOARS.
    10.1016/j.cytogfr.2020.12.002
  43. Duarte-Neves, J.; Cavadas, C.; Pereira de Almeida, L.. "Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100703911&partnerID=MN8TOARS.
    10.1038/s41598-021-82339-5
  44. Klionsky, D.J.; Abdel-Aziz, A.K.; Abdelfatah, S.; Abdellatif, M.; Abdoli, A.; Abel, S.; Abeliovich, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102619204&partnerID=MN8TOARS.
    10.1080/15548627.2020.1797280
  45. Hübener-Schmid, J.; Kuhlbrodt, K.; Peladan, J.; Faber, J.; Santana, M.M.; Hengel, H.; Jacobi, H.; et al. "Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood". Movement Disorders (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113149446&partnerID=MN8TOARS.
    10.1002/mds.28749
  46. Marcelo, A.; Afonso, I.T.; Afonso-Reis, R.; Brito, D.V.C.; Costa, R.G.; Rosa, A.; Alves-Cruzeiro, J.; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death and Disease 12 12 (2021): 8-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-85120082938&partnerID=MN8TOARS.
    10.1038/s41419-021-04404-1
  47. Walter, J.; Bolognin, S.; Poovathingal, S.K.; Magni, S.; Gérard, D.; Antony, P.M.A.; Nickels, S.L.; et al. "The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1". Cell Reports 37 3 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117275453&partnerID=MN8TOARS.
    10.1016/j.celrep.2021.109864
  48. Aguiar, S.I.; Dias, J.N.R.; André, A.S.; Silva, M.L.; Martins, D.; Carrapiço, B.; Castanho, M.; et al. "Highly specific blood-brain barrier transmigrating single-domain antibodies selected by an in vivo phage display screening". Pharmaceutics 13 10 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116780736&partnerID=MN8TOARS.
    10.3390/pharmaceutics13101598
  49. Moreira, R.; Mendonça, L.S.; de Almeida, L.P.. "Extracellular vesicles physiological role and the particular case of disease-spreading mechanisms in polyglutamine diseases". International Journal of Molecular Sciences 22 22 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118955937&partnerID=MN8TOARS.
    10.3390/ijms222212288
  50. Marcelo, A.; Koppenol, R.; de Almeida, L.P.; Matos, C.A.; Nóbrega, C.. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death and Disease 12 6 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107594482&partnerID=MN8TOARS.
    10.1038/s41419-021-03873-8
  51. Diana Duarte Lobo; Rui Jorge Nobre; Catarina Oliveira Miranda; Dina Pereira; João Castelhano; José Sereno; Arnulf Koeppen; Miguel Castelo-Branco; Luís Pereira de Almeida. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications (2020): https://doi.org/10.1186/s40478-020-00955-0.
    10.1186/s40478-020-00955-0
  52. Laetitia S. Gaspar; Magda M. Santana; Carina Henriques; Maria M. Pinto; Teresa M. Ribeiro-Rodrigues; Henrique Girão; Rui Jorge Nobre; Luís Pereira de Almeida. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research". Molecular Therapy - Methods & Clinical Development (2020): https://doi.org/10.1016/j.omtm.2020.07.012.
    10.1016/j.omtm.2020.07.012
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  111. Gomes, J. R.; Lobo, A. C.; Melo, C. V.; Inacio, A. R.; Takano, J.; Iwata, N.; Saido, T. C.; et al. "Cleavage of the Vesicular GABA Transporter under Excitotoxic Conditions Is Followed by Accumulation of the Truncated Transporter in Nonsynaptic Sites". Journal of Neuroscience 31 12 (2011): 4622-4635.
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  112. Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al. "Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats". PLoS ONE 6 7 (2011): 22333-22333.
    Publicado • 10.1371/journal.pone.0022333
  113. Sousa-Ferreira, Lígia; ¿?lvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia; Linden, Rafael. "Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons". PLoS ONE 6 5 (2011): 19745-19745.
    Publicado • 10.1371/journal.pone.0019745
  114. Pereira de Almeida, Luis Fernando Morgado; Nascimento-Ferreira, I.. "Beclin-1 and autophagy: potential for new therapeutics in neurodegeneration". Neurodegenerative Disease Management 1 5 (2011): 349-351. http://www.futuremedicine.com/doi/full/10.2217/nmt.11.56.
    Publicado
  115. Pereira de Almeida, Luis Fernando Morgado. "Células Estaminais Pluripotentes Induzidas (IPSCS) – A mais recente revolução das ciências da vida e da saúde". BOLETIM DO CIM - ROF 97 Mar/Abr 2011 97 (2011): 5-6.
    Publicado
  116. Jorge Nobre, Rui; Pereira de Almeida, Luis. "Gene Therapy for Parkinson's and Alzheimer's Diseases: from the Bench to Clinical Trials". Current Pharmaceutical Design 17 31 (2011): 3434-3445.
    Publicado • 10.2174/138161211798072472
  117. Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al. "Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?". Human Molecular Genetics 19 12 (2010): 2380-2394.
    Publicado • 10.1093/hmg/ddq111
  118. Cardoso, A.L.C.; Costa, P.; de Almeida, L.P.; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M.C.. "Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo". Journal of Controlled Release 142 3 (2010): 392-403.
    Publicado • 10.1016/j.jconrel.2009.11.004
  119. Nobre, Rui Jorge; Cruz, Eugénia; Real, Odete; de Almeida, Luís Pereira; Martins, Teresa C.. "Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing". Journal of Medical Virology 82 6 (2010): 1024-1032.
    Publicado • 10.1002/jmv.21756
  120. Alves, Sandro; Nascimento-Ferreira, Isabel; Auregan, Gwennaëlle; Hassig, Raymonde; Dufour, Noëlle; Brouillet, Emmanuel; Pedroso de Lima, Maria C.; et al. "Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease". PLoS ONE 3 10 (2008): 3341-3341.
    Publicado • 10.1371/journal.pone.0003341
  121. Cardoso, A.L.C.; Simões, S.; de Almeida, L.P.; Plesnila, N.; Pedroso de Lima, M.C.; Wagner, E.; Culmsee, C.. "Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS". Journal of Controlled Release 132 2 (2008): 113-123.
    Publicado • 10.1016/j.jconrel.2008.08.014
  122. Alves, S.; Regulier, E.; Nascimento-Ferreira, I.; Hassig, R.; Dufour, N.; Koeppen, A.; Carvalho, A. L.; et al. "Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease". Human Molecular Genetics 17 14 (2008): 2071-2083.
    Publicado • 10.1093/hmg/ddn106
  123. Vieira, Otilia V.; Hartmann, Diego O.; Cardoso, Carla M. P.; Oberdoerfer, Daniel; Baptista, Marta; Santos, Manuel A. S.; Almeida, Luis; et al. "Surfactants as Microbicides and Contraceptive Agents: A Systematic In Vitro Study". PLoS ONE 3 8 (2008): 2913-2913.
    Publicado • 10.1371/journal.pone.0002913
  124. Cardoso, A. L. C.; Simões, S.; de Almeida, L. P.; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de Lima, M. C.. "siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing". The Journal of Gene Medicine 9 3 (2007): 170-183.
    Publicado • 10.1002/jgm.1006
  125. Teresa Girão da Cruz, M; Cardoso, A L C; de Almeida, L P; Simões, S; Pedroso de Lima, M C. "Tf-lipoplex-mediated NGF gene transfer to the CNS: neuronal protection and recovery in an excitotoxic model of brain injury". Gene Therapy 12 16 (2005): 1242-1252.
    Publicado • 10.1038/sj.gt.3302516
  126. Rego, A. C.; de Almeida, L. P.. "Molecular Targets and Therapeutic Strategies in Huntington's Disease". Current Drug Targets - CNS & Neurological Disorders 4 4 (2005): 361-381.
    Publicado • 10.2174/1568007054546081
  127. P. de Lima, M. C.; Girao da Cruz, M. T.; C. Cardoso, A. L; Simoes, S.; de Almeida, L. P.. "Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System". Current Drug Targets - CNS & Neurological Disorders 4 4 (2005): 453-465.
    Publicado • 10.2174/1568007054546144
  128. Zala, Diana; Bensadoun, Jean-Charles; Pereira de Almeida, Luis; Leavitt, Blair R.; Gutekunst, Claire-Anne; Aebischer, Patrick; Hayden, Michael R.; Déglon, Nicole. "Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice". Experimental Neurology 185 1 (2004): 26-35. http://www.sciencedirect.com/science/article/pii/S0014488603004436.
    Publicado • 10.1016/j.expneurol.2003.09.002
  129. Bensadoun, Jean-Charles; Pereira de Almeida, Luis; Fine, Eric G; Tseng, Jack L; Déglon, Nicole; Aebischer, Patrick. "Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors". Journal of Controlled Release 87 1-3 (2003): 107-115.
    Publicado • 10.1016/S0168-3659(02)00353-X
  130. Régulier, E.; Pereira de Almeida, L.; Sommer, B.; Aebischer, P.; Déglon, N.. "Dose-Dependent Neuroprotective Effect of Ciliary Neurotrophic Factor Delivered via Tetracycline-Regulated Lentiviral Vectors in the Quinolinic Acid Rat Model of Huntington's Disease". Human Gene Therapy 13 16 (2002): 1981-1990.
    Publicado • 10.1089/10430340260355383
  131. De Almeida, L.P.; Ross, C.A.; Zala, D.; Aebischer, P.; Déglon, N.. "Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length". Journal of Neuroscience 22 9 (2002): 3473-3483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036580677&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3278-01.2002
  132. de Almeida, L.Pereira; Zala, D.; Aebischer, P.; Déglon, N.. "Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease". Neurobiology of Disease 8 3 (2001): 433-446.
    Publicado • 10.1006/nbdi.2001.0388
  133. Bensadoun, Jean-Charles; de Almeida, Luis Pereira; Dreano, Michel; Aebischer, Patrick; Deglon, Nicole; Bensadoun, J.-C.; Pereira de Almeida, L.; et al. "Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome". European Journal of Neuroscience 14 11 (2001): 1753-1761. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035783942&partnerID=MN8TOARS.
    Publicado • 10.1046/j.0953-816x.2001.01802.x
  134. Deglon, Nicole; Tseng, Jack L.; Bensadoun, Jean-Charles; Zurn, Anne D.; Arsenijevic, Yvan; Almeida, Luis Pereira De; Zufferey, Romain; Trono, Didier; Aebischer, Patrick. "Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease". Human Gene Therapy 11 1 (2000): 179-190.
    Publicado • 10.1089/10430340050016256
  135. Pereira de Almeida, Luis ; Simões, Sérgio; Brito, Paulo; Portugal, António; Figueiredo, Margarida. "Modeling dissolution of sparingly soluble multisized powders". Journal of Pharmaceutical Sciences 86 6 (1997): 726-732.
    Publicado • 10.1021/js960417w
  136. Simöes, Sérgio; Pereira de Almeida, Luis; Figueiredo, Margarida. "Testing the applicability of classical diffusional models to polydisperse systems". International Journal of Pharmaceutics 139 1-2 (1996): 169-176.
    Publicado • 10.1016/0378-5173(96)04596-6
Capítulo de livro
  1. Henriques, Daniel; Boltze, Johannes; Pereira de Almeida, Luis ; Mendonça, Liliana. "Strategies to Upgrade the Stem Cell Application for Brain Transplantation". In Stem Cell Biology and Regenerative Medicine, 27-58. Springer International Publishing, 2024.
    10.1007/978-3-031-49744-5_2
  2. Lopes, Sara Monteiro; Pereira de Almeida, Luis. "Gene editing and central nervous system regeneration". In Handbook of Innovations in Central Nervous System Regenerative Medicine, editado por Antonio J. Salgado, 399-433. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-818084-6.00011-8
  3. Pereira de Almeida, Luis Fernando Morgado; Nobrega, C.. "Spinocerebellar Ataxia, Jose Gazulla (Ed.), ISBN: 978-953-51-0542-8, InTech,". In Spinocerebellar Ataxia, 0-0. 0, Portugal: In Tech, 2012.
    Publicado
  4. C. Cardoso, A. L; Trabulo, S; Pereira de Almeida, Luis Fernando Morgado; Pedroso de Lima, M. C.. "Interaction of nucleic acids with biological membranes: activation of inflammatory mechanisms". In A Toxicological / Pharmacological Approach to the Chemico-Biological Interactions at the Membrane Level, 0-0. 0: Translational Research Network, 2012.
    Publicado
  5. C. Cardoso, A. L; Trabulo, S; Duarte, Sara; Costa, P.; Pereira de Almeida, Luis Fernando Morgado; Pedroso de Lima, M. C.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Silencing: Theory, Techniques and Applications, 0-0. 0: 0, 2010.
    Publicado
  6. Ribeiro, Sandra Macedo-; Almeida, Luís Pereira de; Carvalho, Ana Luísa; Rego, Ana Cristina. "Polyglutamine Expansion Diseases – the Case of Machado-Joseph Disease". In Interaction Between Neurons and Glia in Aging and Disease, 391-426. Boston, MA: Springer US, 2007.
    Publicado • 10.1007/978-0-387-70830-0_18
Livro
  1. Nóbrega, C.; Simões, A.T.; Duarte-Neves, J.; Duarte, S.; Vasconcelos-Ferreira, A.; Cunha-Santos, J.; Pereira, D.; et al. Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis. 2018.
    10.1007/978-3-319-71779-1_18
  2. Matos, C.A.; Carmona, V.; Vijayakumar, U.-G.; Lopes, S.; Albuquerque, P.; Conceição, M.; Nobre, R.J.; Nóbrega, C.; de Almeida, L.P.. Gene therapies for polyglutamine diseases. 2018.
    10.1007/978-3-319-71779-1_20
  3. Mendonça, L.S.; Onofre, I.; Miranda, C.O.; Perfeito, R.; Nóbrega, C.; de Almeida, L.P.. Stem Cell-Based Therapies for Polyglutamine Diseases. 2018.
    10.1007/978-3-319-71779-1_21
  4. Cardoso, A.L.; Trabulo, S.M.; Duarte, S.P.; Costa, P.M.; Almeida, L.P.; de Lima, M.C.P.. Gene silencing as a promising strategy to target CNS and neurological disorders. 2013.
Poster em conferência
  1. Ferreira-Marques, Marisa; André Carvalho; Ana Catarina Franco; Ana Leal; Botelho, Mariana; Carmo-Silva, Sara; Águas, Rodolfo; et al. Autor correspondente: Aveleira, Célia. "Ghrelin delays premature and accelerated aging phenotype in progeria experimental models". Trabalho apresentado em Pharma PhD Day ¿ Annual meeting of PhD students in Pharmaceutical Sciences, 2023.
  2. Núñez, Jisette; Pereira, Dina; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Pseudotyped lentiviral particles with the SARS-CoV-2 S protein to study drug repurposing and immunological surveillance". Trabalho apresentado em Pharma PhD Day, 2023.
  3. Magda M Santana; D. Adão; De Luca, Pasqualino; R. Martins; Fernandes, Ana Rita; M. M. Pinto; Lopes, Sara M. ; Pereira de Almeida, Luis . Autor correspondente: Pereira de Almeida, Luis. "Neural induction and neuronal maturation of induced pluripotent stem cell is compromised in Machado-Joseph Disease lines". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  4. Fernandes, Ana Rita; Adão, Diana; Lopes, Sara M. ; Henriques, Daniel; Pena, Frederico; Dias, Miguel; Magda M Santana; Pedro Perdigão; Pereira de Almeida, Luis . Autor correspondente: Pereira de Almeida, Luis. "Engineering isogenic neuronal models of ATXN3 knockout in Machado-Joseph Disease patient cells by CRISPR/Cas9". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  5. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Autor correspondente: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  6. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Lopes, Sara; Martins, Inês; Pereira de Almeida, L; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "The Guardians of Balance: Mesenchymal Stem Cells as a Promising Strategy to Restore Blood-brain Barrier Integrity in Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy, 2023.
  7. De Luca, Pasqualino; Diana Adão; Pedro Perdigão; Pereira de Almeida, Luis ; Magda M Santana. "Neuronal maturation of induced pluripotent stem cell is altered in Machado Joseph-Disease cell lines". Trabalho apresentado em ETRS & SPCE-TC joint meeting 2023, 2023.
  8. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em ESGCT 30th Congress, 2023.
  9. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Fernandes, Ana Rita; Lopes, Miguel Monteiro; Pereira, Dina; Duarte, Sónia; et al. "Allele-specific silencing of mutant ATXN3 rescues motor deficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Trabalho apresentado em ESGCT 30th Congress, 2023.
  10. Lobo, Diana Duarte; Quintino, Luis; Silva, Ana Carolina; Henriques, Carina; Ribeiro, Rodrigo; Lopes, Sara Monteiro; Perdigão, Pedro; et al. "CRISPR activation as a therapeutic tool for Spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em ESGCT 30th Congress, 2023.
  11. Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara Monteiro; Pasqua, C; Santos P; Silva, Ana Carolina; Lobo, Diana Duarte; et al. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Spinocerebellar Ataxia Type 3/Machado-Joseph Disease". Trabalho apresentado em CAG Triplet Repeat Disorders GRC, 2023.
  12. Serra, Beatriz; Sónia P. Duarte; Françoise, PIGUET; Nathalie Cartier; Alves, Sandro; Pereira de Almeida, Luis ; Perfeito, Rita. Autor correspondente: Perfeito, Rita. "Validation of the brain-targeting AAV- PHP.eB encoding cholesterol hydroxylase CYP46A1: a promising non-invasive therapeutic strategy for Spinocerebellar Ataxia Type 3". Trabalho apresentado em FENS Regional Meeting (FRM 2023), 2023.
  13. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Trabalho apresentado em FENS Regional Meeting 2023 (FRM), 2023.
  14. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Rafael G. Costa; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "Tackling Machado-Joseph disease through stress granules: is protein CARHSP1 a potential target for therapeutics?". Trabalho apresentado em FENS Regional Meeting 2023, 2023.
  15. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Rafael G. Costa; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "Stress granule protein CARHSP1 as a potential therapeutic strategy for MJD". Trabalho apresentado em ENCODS 2023, 2023.
  16. Perdigão, PRL; Dias, Miguel; Lopes, Sara M. ; Fernandes, Ana Rita; Pena, Frederico; Miguel M. Lopes; Nobre, Rui Jorge; Gaj, Thomas; Pereira de Almeida, Luis. "Engineering CRISPR-Based Editors for Treatment of Machado-Joseph Disease". Trabalho apresentado em ASGCT 26th Annual Meeting, 2023.
  17. Henriques, Daniel; Ricardo Moreira; Pedro Perdigão; Agnete Kirkeby; Pereira de Almeida, L; Liliana S. Mendonça. "Induced pluripotent stem cell-derived Cerebellar Neuronal Progenitors for transplantation in Machado-Joseph Disease". Trabalho apresentado em FENS Regional meeting 2023, 2023.
  18. Moreira, Ricardo; Henriques, Daniel; Nóbrega, Clévio; Pereira de Almeida, Luis; Liliana Mendonça. "Modulation of migration and neuronal differentiation of iPSC-derived Neuroepithelial Stem Cells to improve cell replacement strategies in Machado-Joseph Disease". Trabalho apresentado em FENS Regional meeting 2023, 2023.
  19. Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina. "Mesenchymal Stromal Cells Uptake Mutant Aatxin-3 and Alleviate Late Autophagy and Mitophagy impairments in Spinocerebellar ataxia type-3 (In Vitro and In Vivo) Models.". Trabalho apresentado em Congresso Anual SPDMov 2023, 2023.
  20. Ribeiro, Rodrigo; Pereira, Dina; Reis, Tiago; Lopes, Sara; Ferreira-Marques, Marisa; Fernandes, Rita; Gaspar, Laetitia S; et al. "The Circadian Clock is Disrupted in the YAC Machado-Joseph Disease Mouse Model". Trabalho apresentado em BEB Day 2023 - Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) 17th symposium, 2023.
  21. Koppenol, Rebekah; Matos, Carlos A; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Tackling spinocerebellar ataxia type 2: targeting the ATXN2 gene with CRISPR-Cas-based silencing strategies". Trabalho apresentado em FENS Regional Meeting 2023 (FRM 2023), 2023.
  22. Codêsso, José Miguel; Brito, David V.C.; Mendonça, Liliana; Pereira de Almeida, Luis; Nóbrega, Clévio David Rodrigues. "Unraveling the role of the RBP HSPA8 in Spinocerebellar Ataxia type 3: from pathogenesis to therapeutics". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  23. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  24. Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "Mesenchymal Stromal Cells therapy rescues mitophagy in Machado-Joseph Disease models.". Trabalho apresentado em 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  25. Perdigão, PRL; Matos, Carlos A; Lopes, Sara M. ; Fernandes, Ana Rita; Miguel M. Lopes; Conceição, A; Faro, R; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair.". Trabalho apresentado em 26th Annual Portuguese Society of Human Genetics Meeting, 2022.
  26. Leandro, Kevin; Rufino-Ramos, David; D'Amelio, Tania ; Lopes, Sara; M. Martins, Inês; Lobo, Diana; Faro, Rosário; Perdigão, Pedro; Pereira de Almeida, Luis. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease". Trabalho apresentado em 30th Annual Congress of the European Society of Gene & Cell Therapy, 2022.
  27. Martins, Mariana; Oliveira, Ana Rafaela; Cammarata, Giuseppe; Martins, Solange; Pedro Perdigão; Guedes, Joana; Cardoso, Ana Luísa; et al. "BrainCils: Exploring the missing link between neuronal primary cilia dysfunction and neurodevelopmental disorders: hints from dental stem cell-derived brain organoids". Trabalho apresentado em Synapse Meeting, 2022.
  28. Miguel M. Lopes; J. Paysan; J. Rino; S. M. Lopes; Pereira de Almeida, Luis ; L. Cortes; R. J. Nobre. "Biodistribution analysis of AAV vectors in the brain using tissue clearing coupled to light-sheet microscopy". Trabalho apresentado em ESGCT (European Society for Gene and Cell Therapy) 29th Congress in collaboration with BSGCT, 2022.
  29. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal". Trabalho apresentado em ESGCT 29th Congress, 2022.
  30. David Rufino-Ramos; Leandro, Kevin; Albuquerque, Patrícia Rosado; Carmona, Vitor; Martins, Ines Morgado; Faro, Rosário; Henriques, Carina; et al. "Extracellular vesicles-based delivery of silencing seqeunces for the treatment of Machado-Joseph disease (MJD)/ Spinocerebellar Ataxia type-3 (SCA3)". Trabalho apresentado em ESGCT 29th Congress, 2022.
  31. Henriques, Carina; Lopes, Miguel Monteiro; Albuquerque, Patrícia Rosado; Rufino-Ramos, David; Gaspar, Laetitia S; Duarte, Diana Lobo; Silva, Ana Carolina; et al. "Production and isolation of natural and biologically active exo-AAVs for brain gene delivery". Trabalho apresentado em . ESGCT 29th Congress, 2022.
  32. Henriques, Daniel; Moreira, Ricardo; Pedro Perdigão; Agnete Kirkeby; Pereira de Almeida, Luis ; Mendonça, Liliana S. "Generation and characterization of cerebellar neuronal progenitors for Machado-Joseph Disease treatment". Trabalho apresentado em The 29th Annual Meeting of the European Society of Gene & Cell Therapy ¿ ESGCT 2022, 2022.
  33. Moreira, Ricardo; Henriques, Daniel; Nóbrega, Clévio; Pereira de Almeida, Luis ; Liliana Mendonça. "Modulation of migration and neuronal differentiation of iPSC-derived Neuroepithelial Stem Cells to improve cell therapy in Machado-Joseph Disease". Trabalho apresentado em The 29th Annual Meeting of the European Society of Gene & Cell Therapy ¿ ESGCT 2022, 2022.
  34. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, M. I.; Sara M. Lopes; Duarte, Sonia, P. ; Wagner, E.; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Trabalho apresentado em 29th Congress of the European Society for Gene and Cell Therapy (ESGCT) in collaboration with BSGCT; Edinburgh, Scotland, United Kingdom, 2022.
  35. Lopes, Sara M. ; Miguel M. Lopes; Rui J. Nobre; Clévio Nóbrega; Carlos A. Matos; Ana Vasconcelos-Ferreira; Dina Pereira; et al. Autor correspondente: Pereira de Almeida, L. "Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease". Trabalho apresentado em 27th European Society for Animal Cell Technology Meeting (ESACT2022), Lisbon, Portugal, 2022.
  36. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "A expressão da proteína G3BP1 reduz as anomalias neuropatológicas e motoras em modelos da Ataxia espinocerebelosa, tipo 3". Trabalho apresentado em Congresso SPDMov 2022, 2022.
  37. Carvalhas-Almeida, Catarina; Pereira de Almeida, Luis ; Cavadas, Claudia; Pedro Perdigão; Álvaro, Ana Rita. "Characterization iPSC-derived neuronal cells with potential for disease modeling of human insomnia". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  38. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Autor correspondente: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  39. Carvalhas de Almeida, Catarina; Pereira de Almeida, Luis ; Cavadas, Claudia; Perdigão, Pedro*; Álvaro, Ana Rita* . Autor correspondente: Perdigão, Pedro*. "Insomnia patient-derived iPSC neurons with potential for disease modeling". Trabalho apresentado em World Spleep Congress 2022, Rome, Italy, 2022.
  40. Carvalhas de Almeida, Catarina; Pereira de Almeida, Luis ; Cavadas, Claudia; Perdigão, Pedro*; Álvaro, Ana Rita* . Autor correspondente: Perdigão, Pedro*. "Establishing iPSC-derived neuronal cell model to study human insomnia pathophysiology". Trabalho apresentado em XVI Symposium of Experimental Biology and Biomedicine Doctoral Programme, University of Coimbra, Coimbra, Portugal, 2022.
  41. Koppenol, Rebekah; Afonso-Reis, Ricardo; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "Development of CRISPR-Cas-based strategies for spinocerebellar ataxia type 2". Trabalho apresentado em ESGCT 29th congress, 2022.
  42. Serra, Beatriz; Sónia P. Duarte; Nathalie Cartier; Alves, Sandro; Pereira de Almeida, Luis ; Perfeito, Rita. Autor correspondente: Perfeito, Rita. "Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021.
  43. Santos, D.; Santos, M. I.; Baganha, R.; Nobre, R.; Pereira de Almeida, L; Duarte, S.P.. Autor correspondente: Santos, D.. "Restoration Of Dysregulated MiRNA Levels In A Transgenic Mouse Model Of Machado Joseph Disease As A Novel Therapeutic Approach". Trabalho apresentado em XVII Congress of the Portuguese Society of Neuroscience, 2021.
  44. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  45. Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara; M. Martins, Inês; Lobo, Diana; Paoletta, Manuela; Faro, Rosário; Perdigão, Pedro; Pereira de Almeida, Luis. "Extracellular vesicles transient delivery of CRISPR/Cas9 systems to knock-out ataxin-3 expression". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  46. Ana Carolina Silva; Diana D. Lobo; Carina Henriques; Inês M. Martins; Sara M. Lopes*; Sónia P. Duarte; Elizabeth Wagner; Rui Jorge Nobre; Pereira de Almeida, Luis. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN2021), Coimbra, Portugal., 2021.
  47. Rufino-Ramos, David; Kevin Leandro; Vitor Carmona; Inês M. Martins; Manuela Paolleta; Patrícia R. Albuquerque; Rosário Faro; et al. "Intranasal delivery of extracellular vesicles carrying silencing sequences alleviates Machado-Joseph Disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  48. Braz, Sandra O.; Catarina Vinhas; Henriques, Daniel; Moreira, Ricardo; Rosário Faro; Sónia P. Duarte; Pereira de Almeida, Luis; Liliana S. Mendonça. Autor correspondente: Liliana S. Mendonça. "Cerebellar transplantation of iPSC-derived neuroepithelial stem cells silenced for mutant ATXN3 for Machado-Joseph disease". Trabalho apresentado em Portuguese Society for Neuroscience - SPN 2021, 2021.
  49. Perdigão, Pedro; Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Faro, Rosário; Santana, Magda M; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021.
  50. Barros, Inês; Silva, António; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Pereira de Almeida, Luis ; Oliveira Miranda, Catarina. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  51. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V.C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "FROM MOLECULAR MECHANISMS TO THERAPY: A NEW LENTIVIRAL MOUSE MODEL FOR SPINOCEREBELLAR ATAXIA TYPE 2". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  52. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "ASSESSING THE ROLE OF DIFFERENT G3BP1 REGIONS IN THE MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN SCA2 AND SCA3 DISEASE MODELS". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  53. Henriques, Daniel; Moreira, Ricardo; Pedro Perdigão; Kirkeby, Agnete ; Pereira de Almeida, Luis ; Liliana S. Mendonça. "Generation of cerebellar neuronal progenitors for cell replacement strategies in Machado-Joseph Disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  54. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "MAPPING THE DOMAINS OF RBP-X TOWARDS MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN POLYGLUTAMINE DISEASE MODELS". Trabalho apresentado em IV Jornadas Algarve Biomedical Centre, 2021.
  55. Leandro, Kevin; Rufino-Ramos, David; Lopes, Sara; M. Martins, Inês; Lobo, Diana; Perdigão, Pedro; Faro, Rosário; Pereira de Almeida, Luis. "Extracellular vesicles-mediated delivery of CRISPR/Cas9 tools to treat Machado-Joseph Disease". Trabalho apresentado em 1st Meeting of the Portuguese Network on Extracellular Vesicles, 2021.
  56. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Trabalho apresentado em 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal, 2021.
  57. Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis ; Cavadas, Claudia; Aveleira, Célia. "Human Progeria fibroblasts in culture to study new strategies to delay aging". Trabalho apresentado em JRC Summer School on Non-Animal Approaches in Science: The Three R...evolution, 2021.
  58. Afonso, Inês T.; Carolina Silva, Ana; Henriques, Carina; Lopes, Miguel; Baganha, Rafael; Lima, Patrícia; Kopenol, Rebekah; et al. "Brain distribution, spreading and tropism of a recently developed gene delivery system - mixCapAAV1/2 vector". Trabalho apresentado em AIMS meeting 2021 Research Competition, 2021.
  59. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Matos, Carlos A.; Ricardo Reis; Sandra Tomé; Diogo Teixeira; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020.
  60. Magda M Santana; Silva, Patrick; Gaspar, Laetitia S; Pinto, Maria Manuel ; Carina Henriques; Joana Ribeiro; Inês Cunha; et al. "miRNA expression profile of plasma-derived extracellular from Machado-Joseph Disease patients.". Trabalho apresentado em SCA global and ARCA global, 2020.
  61. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Trabalho apresentado em FENS 2020 Virtual Forum, 2020.
  62. Liliana S. Mendonça; Henriques, Daniel; Vanessa Fernandes; Moreira, Ricardo; Vinhas, Ana C.; Rosário Faro; Duarte, Sónia; Jens C. Schwamborn; Pereira de Almeida, Luis. "Patient specific IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph disease". Trabalho apresentado em FENS 2020 Virtual Forum, 2020.
  63. Almeida, Sara F.F.; Lima, Nuno; Oliveira, Rui; Martins-Marques, Tânia; Ribeiro-Rodrigues, Teresa; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; et al. "Preconditioning mice with osteosarcoma cells-derived secretome promote tumour cells engraftment and lung metastasis development". Trabalho apresentado em Tumor Microenvironment (EACR-AACR Basic and Translational Research Conference in partnership with ASPIC), 2020.
  64. Afonso-Reis, Ricardo; Koppenol, Rebekah; Pereira de Almeida, Luis ; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Silencing ATXN2 expression using CRISPR/Cas9". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), 2020.
  65. Leandro, Kevin; Rufino-Ramos, David; Henriques, Carina; Pereira de Almeida, Luis. "Mini-Poster: Density gradient centrifugation: an improved protocol for extracellular vesicles isolation". Trabalho apresentado em CIBB Meeting 2019, 2019.
  66. Henriques, Carina S.; Lopes, M. M.; Albuquerque, PR; Rufino-Ramos, David; Gaspar, Laetitia; Lobo, Diana Duarte; Duarte, Sónia; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Trabalho apresentado em 3rd BEB Day, 2019.
  67. Leandro, Kevin; Rufino-Ramos, David; Henriques, Carina S.; Pereira de Almeida, Luis Fernando Morgado. "Density Gradient Centrifugation: an improved protocol for Extracellular Vesicles isolation". Trabalho apresentado em 1 st Annual Meeting in Pharmaceutical Sciences, 2019.
  68. Leandro, Kevin; Rufino-Ramos, David; Henriques, Carina S.; Pereira de Almeida, Luis Fernando Morgado. "Isolation of functional extracellular vesicles by sucrose gradient centrifugation". Trabalho apresentado em BEBDay 2019, 2019.
  69. Almeida, Sara F.F.; Lima, Nuno; Oliveira, Rui; Martins-Marques, Tânia; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Secretome derived from osteosarcoma (OS) cells promote tumour cell colonization and lung metastasis formation in pre-treated mice". Trabalho apresentado em CIBB Meeting 2019 - Universidade de Coimbra, 2019.
  70. Álvaro, Ana Rita ; Pereira de Almeida, Luis ; Nguyen, Hoa; Trottier, Yvon; Déglon, Nicole; Perrier, Anselme; Cattaneo, Elena. "Advanced Models of Polyglutamine Disorders (HD, SCA3, SCA7) - ModelPolyQ". Trabalho apresentado em JPND/JPco-fuND final symposium, 2019.
  71. Marques, Andreia; Rufino-Ramos, David; Henriques, Carina; Schwamborn, Jens C.; Perfeito, Rita; Pereira de Almeida, Luis. "Intercellular Transport of Alpha-Synuclein in the context of Parkinson¿s Disease". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  72. Ana Ferreira; Inês Martins; Diana Lobo; Pereira, Dina; Miguel M. Lopes; Sara Lopes; Rosário Faro; et al. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph Disease.". Trabalho apresentado em International Ataxia Research Conference (IARC 2019). Washington, DC. USA., 2019.
  73. Lopes, Sara M; Matos, Carlos Adriano; Conceição, André; Pena, Frederico; Lopes, Miguel Monteiro; Nobre, Rui Jorge; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Trabalho apresentado em International Ataxia Research Conference (IARC 2019), 2019.
  74. Silva, P.; Santana, Magda Matos; Cunha, Inês; Ribeiro, Joana; Pereira, Dina; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Portuguese-mainland cohort of Machado-Joseph Disease: what can be seen after one-year follow-up?". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  75. Rui Jorge Nobre; Lobo, Diana Duarte; Catarina Oliveira Miranda; Pereira, Dina; Castelhano, Joao; Sereno, José Vitor Oliveira; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Blood-brain barrier dysfunction in spinocerebellar ataxia type 3 (Machado-Joseph disease): Results from mouse and human brain tissues". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  76. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and delays cellular senescence in human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 3rd Molecular Biology of Ageing Meeting, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., 2019.
  77. Lopes, Miguel Monteiro; Paysan, Jacques; Rino, José; Lopes, Sara Monteiro; Nobre, Rui Jorge; Cortes, Luisa; Pereira de Almeida, Luis Fernando Morgado; et al. "Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy". Trabalho apresentado em EMBO | EMBL Symposium: Seeing Is Believing ¿ Imaging the Molecular Processes of Life, 2019.
  78. Almeida, Sara F.F.; Lima, Nuno; Martins-Marques, Tânia; Girao, Henrique; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Osteosarcoma-released bioactive factors facilitate lung metastasis by regulating cell adhesion". Trabalho apresentado em Seed and Soil: mechanisms of metastasis (2nd joint EACR-MRS conference), 2019.
  79. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2". Trabalho apresentado em Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Health, 2019.
  80. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the aging phenotype of Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Ageing: models, mechanisms and therapies Conference, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., 2019.
  81. Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; Ferreira, Marco; Teixeira, Diogo; Matos, Carlos A; Koppenol, Rebekah; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio. "RNA-binding proteins: new molecular targets for Polyglutamine diseases?". Trabalho apresentado em XVI Meeting of the Portuguese Society of Neurosciences, 2019.
  82. Koppenol, Rebekah; Marcelo, Adriana; Matos, Carlos A; Carmo-Silva, Sara; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio. "On the role of stress granules in autophagy". Trabalho apresentado em XVI Meeting of the Portuguese Society of Neurosciences, 2019.
  83. Carlos A. Matos; André Conceição; Sara Lopes; Pereira de Almeida, Luis . Autor correspondente: Pereira de Almeida, Luis. "CRISPR-Cas9 as a tool for silencing and correcting ATXN3, the gene causing Machado-Joseph disease.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019). Lisbon, Portugal., 2019.
  84. Carlos A. Matos; André Conceição; Frederico Pena; Sara Lopes; Sónia Duarte; Catarina Miranda; Pereira de Almeida, Luis . Autor correspondente: Pereira de Almeida, Luis. "Transcriptional repression of mutant human ATXN3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019). Lisbon, Portugal., 2019.
  85. Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Garrido, Manuel; Schwamborn, Jens C.; Pereira de Almeida, Luis. "Intersection of Exosome Secretion and Autophagy on Alpha-Synuclein Spreading Profile in Parkinson¿s Disease Cell Models". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  86. Nóbrega, Clévio David Rodrigues ; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A; et al. "CYP46A1 - Gene therapy alleviates Machado-Joseph disease". Trabalho apresentado em XVI Meeting of Portuguese Society for Neuroscience (SPN2019), 2019.
  87. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells ¿ and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  88. Santana, Magda M; Silva, P.; Ribeiro, Joana; Cunha, Inês; Gaspar, Laetitia; Januário, Cristina; Pereira de Almeida, Luis. "Characterization of the Coimbra cohort of Machado-Joseph Disease patients for future clinical trials". Trabalho apresentado em 1st SCA Global Conference, 2019.
  89. Matos, C.A.; Pena, F.; Conceição, A.; Lopes, Sara M. ; Duarte, S.; Miranda, C.; Pereira de Almeida, Luis. "CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model.". Trabalho apresentado em 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA., 2019.
  90. Carmo-Silva, Sara; Clévio, Nóbrega; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm". Trabalho apresentado em Chrononutrition: From Epidemiology to Molecular Mechanism Symposium, 2018.
  91. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Castelhano, João; et al. "Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease". Trabalho apresentado em 26th Annual Congress of European Society of Gene and Cell Therapy, 2018.
  92. Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, Vitor H; Castelhano, João; Petrella, Lorena I; Sereno, José; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Assessing cerebellar neurometabolic biomarkers by in vivo Magnetic Resonance Spectroscopy in a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em 26th Annual Congress of European Society of Gene and Cell Therapy, 2018.
  93. Tomé, Sandra; Marcelo, Adriana; Carmo-Silva, Sara; Ferreira, Marco; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy". Trabalho apresentado em 11th Forum of Neuroscience (FENS), 2018.
  94. Carmo-Silva, Sara; Clévio, Nóbrega; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 a novel regulator of circadian rhythm". Trabalho apresentado em EMBO|EMBL Symposium: Biological Oscillators: Design, Mechanism, Function, 2018.
  95. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Castelhano, João; et al. "Non-Invasively Silencing and Monitoring Machado-Joseph Disease". Trabalho apresentado em The American Society of Gene & Cell Therapy meeting, 2018.
  96. Albuquerque, Patricia Rosado; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara Monteiro; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive delivery with hybrid extracelular vesicles for therapy of Machado Joseph-disease". Trabalho apresentado em International Society for Extracellular Vesicles Annual Meeting, 2018.
  97. Santana, Magda M; Gaspar, Laetitia; Perfeito, Rita; Albuquerque, Patrícia; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Nobre, Rui Jorge; et al. "Optimization of a size exclusion chromatography protocol to isolate plasma-derived extracelular vesicles for transcriptional biomarkers research". Trabalho apresentado em International Society for Extracellular Vesicles Annual Meeting, 2018.
  98. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, 2018.
  99. Santana, M.M.*; Lopes, S. M.* ; Onofre, I.; Álvaro, A.R.; Di Donato, R.; Pereira de Almeida, Luis ; *Equally contributed. "Generation of Machado-Joseph disease induced pluripotent cell lines and isogenic controls, using the CRISPR/Cas9 technology.". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC 2017). Pisa, Italy., 2017.
  100. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive and allele-specific silencing of mutant ataxin-3 alleviates neuropathology and motor deficits of Machado-Joseph disease.". Trabalho apresentado em IARC 2017 Conference - 2nd International Ataxia Research Conference, 2017.
  101. Matos, C.A.; Lopes, S.; Pereira de Almeida, Luis. "CRISPR-Cas9 as a tool for Machado-Joseph disease treatment and animal model generation.". Trabalho apresentado em EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany., 2017.
  102. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Pereira, Dina; Vasconcelos-Ferreira, Ana; Nobrega, Clévio; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017.
  103. Lopes, Sara Monteiro; Nobre, Rui Jorge; Nobrega, Clévio; Lopes, Miguel Monteiro; Matos, Carlos Adriano; Sanjana, Neville; Hsu, Patrick; et al. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC 2017), 2017.
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  105. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive AAV9-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em 24th Annual Congress of European Society of Gene and Cell Therapy, 2016.
  106. Aveleira, Célia; Botelho, Mariana; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Cell Symposia ¿ Aging and Metabolism, Sitges, Spain., 2016.
  107. Gonçalves, Nélio; Machado, Nuno J.; Souza, Carolina M.; Fernandes, Sara B.; Simões, Ana; Simões, Ana; Pereira de Almeida, Luis Fernando Morgado; Cunha, R. A.. "Selective amygdala neuronal down-regulation of adenosine A2A receptors prevents mood-related modifications". Trabalho apresentado em The 7th International Society of Neurochemistry Conference: Synaptic function and dysfunction in brain diseases, 2016.
  108. Simões, Ana; Machado, Nuno J.; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana; Nunes, Ana; Pereira de Almeida, Luis Fernando Morgado; et al. "Adenosine A2A receptors in the amygdala control synaptic plasticity and fear memory". Trabalho apresentado em The 7th International Society of Neurochemistry Conference: Synaptic function and dysfunction in brain diseases, 2016.
  109. Perfeito, Rita; Anjos, Vanessa; Nobre, Rui Jorge; Garrido, Manuel; Pereira de Almeida, Luis Fernando Morgado. "Autophagy activation prevents alpha-synuclein secretion in exosomes". Trabalho apresentado em Annual Meeting ¿ ISEV, 2016.
  110. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2: a new player in central regulation of regulation of energy balance.". Trabalho apresentado em EMBO Workshop ¿ Neural control of metabolism and eating behavior, Cascais, Portugal., 2016.
  111. Aveleira, Célia; Cortes, Luísa; Ferreira-Marques, Marisa; Leal, Ana; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ghrelin enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 8th Progeria Research Foundation International Scientific Workshop ¿ Across the Table, Around the Globe, Cambridge, MA, USA., 2016.
  112. Petrella, Li; Sereno, José V; Miranda, Catarina; Nobre, Rui Jorge; Castelhano, João; Pereira de Almeida, Luis Fernando Morgado; Castelo-Branco, Miguel. "Evaluation of brain structures volumes on a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em VII Annual Meeting of IBILI, 2015.
  113. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Aveleira, Célia; Álvaro, Ana Rita ; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism.". Trabalho apresentado em XIII CNC Annual Meeting, Coimbra, Portugal., 2015.
  114. Mendonça, Liliana; Onofre, Isabel; Nóbrega, Clévio; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Generation of gene-silenced human iPS-derived NSC for transplantation in Machado Joseph Disease". Trabalho apresentado em World conference on regenerative medicine, 2015.
  115. Botelho, Mariana; Aveleira, Célia; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons.". Trabalho apresentado em 11th NPY-PYY-PP International Meeting, Leipzig, Germany., 2015.
  116. Carmo-Silva, Sara; Nóbrega, Clévio; Ferreira-Marques, Marisa; Botelho, Mariana; Álvaro, Ana Rita ; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Impact of hypothalamic ataxin-2 on energy balance and metabolic profile.". Trabalho apresentado em 9th IBRO World Congress on Neuroscience, Rio de Janeiro, Brazil., 2015.
  117. Aveleira, Célia; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome fibroblasts.". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA., 2015.
  118. Aveleira, Célia; Carmo-Silva, Sara; Botelho, Mariana; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Ótin, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging.". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA., 2015.
  119. Botelho, Mariana; Aveleira, Célia; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Autophagy in the hypothalamus: the role of Neuropeptide Y.". Trabalho apresentado em 9th IBRO World Congress on Neuroscience, Rio de Janeiro, Brazil., 2015.
  120. Carmo-Silva, Sara; Nóbrega, Clévio; Botelho, Mariana; Ferreira-Marques, Marisa; Aveleira, Célia; Pulst, Stefan; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 regulates energy balance and metabolism.". Trabalho apresentado em Neural Control of Metabolic Physiology and Diseases Keystone Symposia on Molecular and Cellular Biology, Snowbird, Utah, USA., 2015.
  121. Gonçalves, Nélio; Simões, Ana; Prediger, R.D.; Cunha, R.A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine alleviates progressive motor deficits in Machado-Joseph disease transgenic mice". Trabalho apresentado em Ataxia Research Conference 2015, 2015.
  122. Albuquerque, Patrícia; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Polyglutamine expansion in the human ataxin-3 protein changes the extracellular vesicles RNA and protein content". Trabalho apresentado em First Iberian meeting on extracelular vesicles, 2015.
  123. Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui Jorge; Barbosa, Joana; Carreira, Isabel M; Carvalho, Lina; et al. "Characterization of a human Machado-Joseph Disease neuronal cell model derived from induced pluripotent stem cells". Trabalho apresentado em 9th Annual meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2015.
  124. Lopes, Sara; Nobre, Rui Jorge; Nobrega, Clévio; Sanjana, Neville; Cong, Le; Hsu, Patrick; Ran, Fei Ann; Zhang, Feng; Pereira de Almeida, Luis Fernando Morgado. "Gene editing strategies towards Machado Joseph disease". Trabalho apresentado em EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification", 2015.
  125. Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana; den Dunnen, W.F.A.; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado. "Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph disease". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  126. Carmona, Vitor; Cunha-Santos, Janete; Simões, Ana; Pereira de Almeida, Luis Fernando Morgado. "Ataxin-3 3¿UTR reduces neuropathology in a lentiviral mouse model of Machado-Joseph disease ¿ a role for microRNAs ?". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  127. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the phenotype of a mousse model of human premature aging". Trabalho apresentado em XII CNC Annual Meeting, University of Coimbra, Coimbra, Portugal, 2014.
  128. Nóbrega, Clévio; Carmo-Silva, Sara; Pereira de Almeida, Luis Fernando Morgado. "Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target". Trabalho apresentado em 5th Ataxia Investigators Meeting (AIM), 2014.
  129. Albuquerque, Patricia; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "POLYGLUTAMINE EXPANSION IN THE HUMAN ATAXIN3 PROTEIN CHANGES THE EXOSOMAL microRNA CONTENT OF NEURONAL CELLS". Trabalho apresentado em 2nd Geivex Symposium Extracellular vesicles: From the bench to the clinics, 2014.
  130. Nóbrega, Clévio; Carmo-Silva, Sara; Pereira de Almeida, Luis Fernando Morgado. "Ataxin-2 as a new molecular target for Machado-Joseph Disease". Trabalho apresentado em Champalimaud Neuroscience Programme Symposium, 2013.
  131. Aveleira, Célia; Botelho, Mariana; Pascoal, Jorge; Carmo-Silva, Sara; Nóbrega, Clévio; Sousa-Ferreira, Lígia; Álvaro, Ana Rita ; et al. "Neuropeptide Y, a caloric restriction mimetic, induces autophagy in hypothalamic neurons.". Trabalho apresentado em EMBO Young Scientists¿ Forum, Lisbon, Portugal, 2013.
  132. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the phenotype of a mousse model of human premature aging". Trabalho apresentado em 7th Progeria Research Foundation International Workshop ¿ Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, Bethesda, MD, USA, 2013.
  133. Aveleira, Célia; Botelho, Mariana; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Ferreira-Marques, Marisa; Nóbrega, Clévio; López-Otín, Carlos; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging.". Trabalho apresentado em 7th Progeria Research Foundation International Workshop ¿ Hand in Hand: Basic and Clinical Science Working Together Toward the Cure, Bethesda, MD, USA, 2013.
  134. Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em XIII REunião da Sociedade Portuguesa de neurociências, 2013.
  135. Botelho, Mariana; Aveleira, Célia; Pascoal, Jorge; Carmo-Silva, Sara; Sousa-Ferreira, Lígia; Nóbrega, Clévio; Álvaro, Ana Rita ; et al. "Neuropeptide Y is an autophagy inducer in hypothalamic neurons". Trabalho apresentado em X CNC Meeting, 2012.
  136. Botelho, Mariana; Aveleira, Célia; Sousa-Ferreira, Lígia; Jorge, Pascoal; Nóbrega, Clévio; Álvaro, Ana Rita ; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Role of NPY on autophagy in hypothalamus: a caloric restriction mimetic?". Trabalho apresentado em 10th International NPY-PYY-PP Meeting, Montreal, Canada, 2012.
  137. Nobre, Rui Jorge; Herraez-Hernandez, Elsa; Fei, Jian-Wei; Cruz, Eugénia; Real, Odete; Langbein, Lutz; Kaden, Sylvia; et al. "Unraveling the role of common, rare and novel human papillomaviruses in the pathogenesis of cervical cancer". Trabalho apresentado em 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
  138. Simões, Ana Teresa Antunes; Gonçalves, Nélio; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration.". Trabalho apresentado em The Biology of Calpains in Health and Disease, 2010.
  139. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel. "Silencing Machado-Joseph disease through the systemic route". Trabalho apresentado em Workshop ¿Molecular Mechanisms in Neurodegeneration: From Molecule to Cures.", 2010.
  140. Gonçalves, Nélio; Simões, Ana Teresa Antunes; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience., 2009.
  141. Simões, Ana Teresa Antunes; Gonçalves, Nélio; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Calpains promote mutant ataxin-3 translocation to the nucleus and neurodegeneration.". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience, 2009.
  142. Gonçalves, Nélio; Simões, Ana Teresa Antunes; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em XI Annual Meeting of the Portuguese Society for Neuroscience, 2009.
  143. Gonçalves, Nélio; Simões, Ana Teresa Antunes; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Adenosine A2A receptors antagonism delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease.". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  144. Simões, Ana Teresa Antunes; Gonçalves, Nélio; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of calpains prevents translocation of mutant ataxin-3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  145. Simões, Ana; Nóbrega, Clévio; Déglon, Nicole; Duarte, Carlos B.; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of calpains in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em Lentiviral vectors: concepts, practice, hope and reality, 2008.
  146. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado; Martins, Teresa. "Cervical Cancer: factors modulating susceptibility and resistance to cancer development". Trabalho apresentado em IV Reunião do Centro de Neurociências e Biologia Celular da Universidade de Coimbra, 2006.
  147. Nobre, Rui Jorge; Prazeres, H; Real, O; Cruz, E.; Figueiredo, P.; Lacerda, M; Pereira de Almeida, Luis Fernando Morgado; Martins, Teresa. "Genotype spectrum of Human Papillomavirus infection in Portuguese population: detection of HPV type 53 and 67 in cervical cancer". Trabalho apresentado em 23rd International Conference and Clinical Workshop on Papillomavirus, 2006.
  148. Pereira de Almeida, Luis ; Bensadoun, J.-C.; Regulier, E.; Zala, D.; Aebischer, P.; Deglon, N.. "Lentiviral vectors for therapeutic and functional studies in Huntington’s disease". Trabalho apresentado em Gordon research Conference: CAG Triplet Repeat Disorders, Il Ciocco Barga, Italy, 2003.
  149. D. Zala; Pereira de Almeida, Luis ; J.-C. Bensadoun; B. R. Leavitt ; P. Aebischer; N. Déglon; M. R. Hayden. "Lentiviral-mediated delivery of ciliary neurotrophic factor protects striatal neurones in a transgenic model of Huntington’s disease". Trabalho apresentado em Forum of European Neuroscience (FENS) 2002, Paris, França, 2002.
  150. E. Régulier; Pereira de Almeida, Luis ; B. Sommer; P. Aebischer; N. Déglon. "Dose-Dependent Neuroprotective Effect of CNTF delivered via Tetracycline-Regulated Lentiviral Vectors in the quinolinic acid rat model of Huntington’s disease". Trabalho apresentado em 5th Annual Meeting, American Society of Gene Therapy (ASGT), Boston, EUA, 2002.
  151. J.-L. Ridet; B. Sommer; A. Spicher; Pereira de Almeida, Luis ; N. Déglon; P. Aebischer. "Development of a lentiviral regulatable system for GDNF gene delivery.". Trabalho apresentado em Meeting of the Society for Neuroscience, San Diego, EUA, 2001.
  152. J.-Ch. Bensadoun; Pereira de Almeida, Luis ; M. Dreano; P. Aebischer; N. Déglon. "Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington’s disease.". Trabalho apresentado em Meeting of the Society for Neuroscience, San Diego, EUA, 2001.
  153. Pereira de Almeida, Luis ; D. Zala; P. Aebischer; N. Déglon. "Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a neuropathology modulated by polyglutamine repeat size, huntingtin expression levels and protein length". Trabalho apresentado em 27th Meeting of the Federation of European Biochemical Societies in Collaboration with the Pan-American Association for Biochemical Molecular Biology , Lisboa, Portugal, 2001.
  154. N. Déglon; Pereira de Almeida, Luis ; D. Zala; P. Aebischer. "Lentiviral-mediated HD models: impact of protein length, CAG repeat size and expression levels". Trabalho apresentado em American Society of Gene Therapy (ASGT) - 4th Annual Meeting, Seattle, EUA, 2001.
  155. J.-C. Bensadoun; Pereira de Almeida, Luis ; J.L. Tseng; E. Fine; A. Zurn; N. Déglon; P. Aebischer. "Strategies for the continuous delivery of neurotrophic factors to the CNS: comparison of polymer rods, encapsulated cells and lentiviral vectors". Trabalho apresentado em Society for Neuroscience, New Orleans, EUA, 2000.
  156. Pereira de Almeida, Luis ; D. Zala; R. Gaspar; P. Aebischer; N. Déglon. "Lentiviral mediated delivery of mutated Huntingtin fragments as a new strategy to develop animal models of Huntington’s disease". Trabalho apresentado em Gene Therapy NFP37 Annual Meeting, Friburgo, Suíça, 2000.
  157. J.-C. Bensadoun; Pereira de Almeida, Luis ; J.L. Tseng; E. Fine; A. Zurn; N. Déglon; P. Aebischer. "Polymer rods, encapsulated cells and lentiviral vectors for the continuous delivery of neurotrophic factors to the CNS". Trabalho apresentado em Meeting of the European Life-Sciences Organization (ELSO), Genebra, Suíça, 2000.
  158. Pereira de Almeida, Luis ; D. Zala; R. Gaspar; P. Aebischer; N. Déglon. "Lentiviral mediated delivery of mutated Huntington fragments as a new strategy to develop animal models of Huntington’s disease". Trabalho apresentado em Meeting of the European Life-Sciences Organization (ELSO), Genebra, Suíça, 2000.
  159. Pereira de Almeida, Luis ; D. Zala; J.L. Tseng; R. Gaspar; P. Aebischer; N. Déglon. "Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington’s disease". Trabalho apresentado em Forum of European Neuroscience Societies (FENS) 2000 Millenium Meeting, Brighton, Reino Unido, 2000.
  160. Pereira de Almeida, Luis ; B. Menendez; R. Gaspar. "Optimization of the encapsulation of a model protein – FITC-BSA – in PLGA and PLA microparticles". Trabalho apresentado em 12th Annual Meeting of the G.T.R.V. Brussels, Belgium, 1998.
  161. Pereira de Almeida, Luis ; B. Menendez; R. Gaspar. "PLGA microparticles as carriers for proteins:Technological aspects with the FITC-BSA model.". Trabalho apresentado em 2nd World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology and 8th International Conference on Pharmaceutical Technology of APGI/44th Annual congress of APV. Proc. , 505. Paris, France, 1998.
  162. Pereira de Almeida, Luis ; P. Brito; A. Sousa; A. Portugal; M. Figueiredo. "Modelling dissolution of sparingly soluble powders". Trabalho apresentado em APGI European Symposium on Formulation of Poorly-available Drugs for Oral Administration. Paris, France, 1996.
  163. Pereira de Almeida, Luis ; P. Brito; A. Sousa; A. Portugal; M. Figueiredo. "Modelling the dissolution kinetics of ibuprofen". Trabalho apresentado em 1st Spanish-Portuguese Conference on Controlled Drug Delivery. Santiago de Compostela, Spain, 1995.
  164. Pereira de Almeida, Luis ; S. Simões; A. Sousa; M. Figueiredo. "Testing the applicability of the cube root law to the dissolution of ibuprofen using a particle conter". Trabalho apresentado em 1st World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology. Budapest, Hungary, 1995.
Relatório
  1. Faculdade de Farmácia. 2015. Relatório de Estágio realizado na Farmácia Peixinho. https://repositorio-aberto.up.pt/handle/10216/83967.
Resumo em conferência
  1. Rodrigo F.N. Ribeiro; Dina Pereira; Tiago Reis; Sara Lopes; Marisa Ferreira-Marques; Rita Fernandes; Leatitia S Gaspar; et al. "Investigating the Clock Components and Circadian Activity in the YAC-MJD Mouse Model". Trabalho apresentado em SPF Meeting 2023 - Reunião da Sociedade Portuguesa de Farmacologia, Farmacologia Clínica e de Toxicologia, Coimbra, 2023.
  2. Beatriz Machado Serra; Duarte, Sónia; Nathalie Cartier; Sandro Alves; Pereira de Almeida, Luis ; Rita Perfeito. Autor correspondente: Rita Perfeito. "Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Trabalho apresentado em 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, 2022.
    Publicado
  3. Lopes, Sara M. ; Miguel M. Lopes; Rui Nobre; Clévio Nóbrega; Matos, Carlos A; Ana Vasconcelos-Ferreira; Neville Sanjana; et al. Autor correspondente: Pereira de Almeida, Luis. "Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), Virtual Conference, 2021.
    Publicado
  4. Conceição, André; Koppenol, Rebekah; Tomé, Sandra; Carmo-Silva, Sara; Matos, Carlos A; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "A RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24th Anual Meeting of Portuguese Human Genetics Society. Proceedings published in Medicine, 2021.
    Publicado • 10.1097/MD.0000000000023585
  5. Carmo-Silva, Sara; Nóbrega, Clévio David Rodrigues ; Ferreira-Marques, Marisa; Botelho, Mariana; Pulst, Stefan M; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock.". Trabalho apresentado em European and International Congress of Obesity 2020 (ECO-ICO). Proceedings published in Obesity Reviews, 2020.
    Publicado • DOI: 10.1111/obr.13115
  6. Afonso, Inês T.; Silva, Ana Carolina; Henriques, Carina; Lopes, Miguel; Baganha, Rafael; Lima, Patricia; Koppenol, Rebekah; et al. "mixCapAAV1/2 Vector: Distribution, Spreading and Tropism Analysis in Normal Mice". Trabalho apresentado em 24th Annual Meeting of the PortugueseSociety for Human Genetics (SPGH), Lisboa, 2020.
  7. Bras, A; Cunha, I; Silva, Patrick; Ribeiro, JA; Santana, MM; Pereira de Almeida, L; Januário, Cristina. "Characterization of a Portuguese cohort of Machado-Joseph disease: besides ataxia". Trabalho apresentado em 5th Congress of the European Academy of Neurology (EAN), Oslo, 2019.
    Publicado
  8. Carmo-Silva, Sara (9D11-2BDFA256); Nóbrega, Clévio David Rodrigues ; Ferreira-Marques, Marisa; Pulst, Stefan M; Pereira de Almeida, Luis ; Cavadas, Claudia. "Hypothalamic ataxin-2: Resetting the clock on obesity". Trabalho apresentado em 26th European Congress on Obesity, Gasglow, 2019.
    Publicado
  9. Nobre, Rui Jorge; Saraiva, Joana; Susana, Paixão; Fusco, Clelia; Santana, Magda M; Miranda, Catarina Oliveira; Lorena, Petrella; et al. "A miRNA-based gene therapy approach to knock-down mutant ATXN3: Alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2019.
    Publicado
  10. Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Nobre, Rui Jorge; Manuel, Garrido; Christian, Scwamborn Jens; Pereira de Almeida, Luis Fernando Morgado. "Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson¿s disease cell models. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Publicado
  11. Albuquerque, Patrícia; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara; Ribeiro-Rodrigues, TM; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive brain delivery with hybrid extracellular vesicles (EVs) for therapy of Machado-Joseph disease (MJD), Journal of Extracellular Vesicles". 2018.
    Publicado
  12. Gaspar, Laetitia; Santana, Magda M; Perfeito, Rita; Albuquerque, Patrícia; Ribeiro-Rodrigues, Teresa M; Girao, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Optimization of a size-exclusion chromatography protocol to isolate plasma-derived extracellular vesicles for transcriptional biomarkers research, Journal of Extracellular Vesicles". 2018.
    Publicado
  13. Lopes, Sara; Nobre, Rui Jorge; Nobrega, Clévio; Lopes, Miguel; Matos, Carlos; Sanjana, Neville; Hsu, Patrick; et al. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease, Molecular Therapy". 2018.
    Publicado
  14. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Sereno, José; et al. "Non-Invasively Silencing and Monitoring Machado-Joseph Disease. Molecular Therapy". 2018.
    Publicado
  15. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, Human Gene Therapy". 2018.
    Publicado
  16. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Sereno, José; et al. "Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease, Human Gene Therapy". 2018.
    Publicado
  17. Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, VH; Castelhano, João; Petrella, Lorena; Sereno, José; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Assessing cerebellar neurometabolic biomarkers by in vivo magnetic resonance spectroscopy in a transgenic mouse model of Machado-Joseph disease. HUMAN GENE THERAPY". 2018.
    Publicado
  18. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms. . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Publicado
  19. Duarte-Neves, Joana; Cunha-Santos, Janete; Gonçalves, Nélio; Simões, Ana Teresa Antunes; den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y alleviates Machado¿Joseph disease". Trabalho apresentado em Advances in NPY Research, 2016.
    Publicado • 10.1016/j.npep.2015.11.013
  20. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive AAV9-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease, Human Gene Therapy". 2016.
    Publicado
  21. Gonçalves, Nélio; Simões, Ana Teresa Antunes; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Blockade of adenosine receptors by caffeine provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Publicado • 10.3389/conf.neuro.01.2009.11.105
  22. Pereira de Almeida, Luis ; D. Zala; J.L. Tseng; R. Gaspar; P. Aebischer; N. Déglon. "Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington’s disease.". Trabalho apresentado em Forum of European Neuroscience Societies (FENS) 2000 Millenium Meeting, Brighton, 2000.
    Publicado
Tese / Dissertação
  1. Pinto, Maria Manuel Martins. "Brain-enriched plasma-derived extracellular vesicles as biomarkers for Machado-Joseph disease". Mestrado, 2020. http://hdl.handle.net/10316/93031.
  2. Canoeiro, Nuno Rafael Fernandes. "Relatório de Estágio e Monografia intitulada "Transposição de Escala da Produção de Vírus Adeno-Associados"". Mestrado, 2020. http://hdl.handle.net/10316/92923.
  3. Mano, Diogo Miguel Alves Pratas. "Relatórios de Estágio e Monografia Intitulada"Imunidade pré-existente a AAV: Estratégias para desenvolver vetores AAV com evasão imune aprimorada"". Mestrado, 2020. http://hdl.handle.net/10316/93068.
  4. Santos, Maria Inês Nunes dos. "MicroRNA profiling in human cell-based models of Machado-Joseph disease". Mestrado, 2020. http://hdl.handle.net/10316/92999.
  5. Carreiras, Rafael Baganha. "Development of Single-Step Affinity Chromatography Protocols for the Purification of Adeno-Associated Viral Vectors.". Mestrado, 2020. http://hdl.handle.net/10316/92998.
  6. Ferreira, Victor Leonel Vieira. "SARS-CoV-2 detection methods: where are we now?". Mestrado, 2020. http://hdl.handle.net/10316/93052.
  7. Oliveira, Ana Daniela Esteves. "Phenotypic characterization of cellular and animal models of Machado-Joseph disease". Mestrado, 2020. http://hdl.handle.net/10316/93000.
  8. Pereira, Dina Maria da Silva Rodrigues. "The role of ageing in polyglutamine-induced neurodegeneration. A study in Machado-Joseph disease models". Doutoramento, 2020. http://hdl.handle.net/10316/90762.
  9. Fernandes, Irina Marques da Silva. "Relatórios de Estágio e Monografia intitulada "Edição de Bases: o futuro da edição de genes?". Mestrado, 2020. http://hdl.handle.net/10316/93078.
  10. Barros, Maria Inês Veiga de Almeida. "Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease". Mestrado, 2019. http://hdl.handle.net/10316/86421.
  11. Silva, Maria Carolina Sousa. "Ins2Akita mouse as a model of diabetic retinopathy: angiogenic and inflammatory characterization for selection of therapeutic targets". Mestrado, 2018. http://hdl.handle.net/10316/84609.
  12. Kreutzer, Bruna. "Polymeric Micelles to improve Salinomycin delivery to cancer cells.". Mestrado, 2018. http://hdl.handle.net/10316/84418.
  13. Moreira, Ricardo Gomes; Simões, Ana Teresa Antunes. "Investigation of mutant ataxin-3 spreading in Machado-Joseph Disease". Mestrado, 2018. http://hdl.handle.net/10316/84615.
  14. Silva, Maria Margarida Carvalho Vale da. "Relato´rios de Esta´gio e Monografia intitulada “Exossomas – novos vetores para o transporte, entrega e tratamento de doenças do cérebro”". Mestrado, 2017. http://hdl.handle.net/10316/83667.
  15. Ferreira, Joana Catarina Martins. "Relatórios de Estágio e Monografia intitulada “CRISPR/Cas9 na produção de modelos de doença do cérebro”.". Mestrado, 2017. http://hdl.handle.net/10316/83725.
  16. Silva, Márcio Alexandre da Costa e. "Relatórios de Estágio e Monografia intitulada "Exossomas e outras vesículas extracelulares como biomarcadores"". Mestrado, 2017. http://hdl.handle.net/10316/83665.
  17. Silva, Patrick Joel da. "Machado-Joseph Disease: Understanding Epidemiologic and Clinical Features and a Potential New Therapeutic Entity". Mestrado, 2017. http://hdl.handle.net/10316/83750.
  18. Vijayakumar, Udaya Geetha. "Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease". Doutoramento, 2017. http://hdl.handle.net/10316/32393.
  19. Carmona, Vitor Manuel Martins. "MicroRNAs targeting Ataxin-3 mRNA in Machado-Joseph disease: from pathogenesis to therapy". Doutoramento, 2017. http://hdl.handle.net/10316/32274.
  20. Santos, Janete Antónia da Cunha. "Delaying neurodegeneration through caloric restriction approaches: From mechanisms to molecular therapy". Doutoramento, 2017. http://hdl.handle.net/10316/32273.
  21. Freitas, Ana Karolina Seco das Neves. "Défice Cognitivo Ligeiro e Doença de Alzheimer: as diferenças numa perspetiva proteómica". Mestrado, 2017. http://hdl.handle.net/10316/83738.
  22. Conceição, Mariana Oliveira. "Non-viral silencing of Machado-Joseph disease through the systemic route". Doutoramento, 2016. http://hdl.handle.net/10316/29551.
  23. Ferreira, Marco António Rodrigues. "PERK inhibition role in Spinocerebellar ataxias". Mestrado, 2016. http://hdl.handle.net/10316/40778.
  24. Saraiva, Joana Isabel Rajão. "Non-invasive viral-mediated gene therapy for Machado-Joseph disease". Mestrado, 2016. http://hdl.handle.net/10316/34064.
  25. Neves, Joana Filipa Duarte das. "Neuropeptide Y gene transfer for neuroprotection in Machado-Joseph Disease". Doutoramento, 2016. http://hdl.handle.net/10316/29339.
  26. Martinho, Luís Miguel Lopes. "Novos sistemas para penetração da barreira hematoencefálica : das microbolhas à focagem de ultrassons". Mestrado, 2015. http://hdl.handle.net/10316/30362.
  27. Martins, Joana Margarida Cardoso Serra. "Evaluation of the potential anti-inflammatory and neuroprotective effect of a FAAH inhibitor in glaucome models". Mestrado, 2015. http://hdl.handle.net/10316/30355.
  28. Cruz, Ana Rita Queirós da. "Gene therapy-based strategies for glioblastoma towards chemosensitization : use of gemini surfactants as drug delivery systems". Mestrado, 2015. http://hdl.handle.net/10316/30357.
  29. Pereira, João Miguel Calmeiro. "Optogenetics and biotechnology : production and in vitro characterization of Ab-Initio designed channelrhodopsin-2 mutants". Mestrado, 2015. http://hdl.handle.net/10316/30363.
  30. Paixão, Susana Manuel da Silva Letra Lopes. "Trehalose alleviates neuropathological and motor behaviour deficits of a transgenic mouse model of Machado-Joseph disease". Mestrado, 2015. http://hdl.handle.net/10316/31067.
  31. Nunes, Frederico de Brito; Veiga, Luís António Martins Leitão de Almeida. "Relatório de estágio em farmácia comunitária". Mestrado, 2014. http://hdl.handle.net/10316/37732.
  32. Araújo, Maurício Alves. "Custo-efetividade da utilização de um teste farmacogenético para o Alopurinol em doentes portugueses diagnosticados com gota". Mestrado, 2014. http://hdl.handle.net/10316/36229.
  33. Silva, Teresa Maria Pereira da. "Multipotent mesenchymal stromal cells for Machado Joseph disease therapy". Mestrado, 2014. http://hdl.handle.net/10316/30598.
  34. Videira, Rita Margarida Almeida Santos. "Cerebrospinal fluid biomarkers for neurodegenerative disorders". Mestrado, 2013. http://hdl.handle.net/10316/25736.
  35. Oliveira, Diogo Fernando Gonçalves de. "Terapia génica da insuficiência cardíaca: potencial clínico da sobrexpressão da SERCA2a". Mestrado, 2013. http://hdl.handle.net/10316/26154.
  36. Correia, Liliana dos Santos Tavares. "Células estaminais pluripotentes induzidas no estudo de mecanismos de doença e avaliação de novas terapias". Mestrado, 2013. http://hdl.handle.net/10316/25942.
  37. Gonçalves, Nélio da Mota. "Gene transfer approaches to study the role of adenosine A2A receptors in Machado-Joseph disease". Doutoramento, 2013. http://hdl.handle.net/10316/23679.
  38. Ferreira, Ana Cristina Lopes Vasconcelos. "Pharmacological activation of autophagy in Machado-Joseph disease". Mestrado, 2012. http://hdl.handle.net/10316/22070.
  39. Bexiga, Mariana Godinho. "Cationic Nanoparticles: Friend or Foe? Deciphering the mechanisms of cell death induced by cationic nanoparticles". Doutoramento, 2012. http://hdl.handle.net/10316/18398.
  40. Simões, Ana Teresa. "Calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease". Doutoramento, 2012. http://hdl.handle.net/10316/20543.
  41. Silva, Sara Matias Carmo. "Interaction of ataxin-2 and ataxin-3 in Machado-Joseph disease". Mestrado, 2011. http://hdl.handle.net/10773/8179.
  42. Almeida, Luís Fernando Morgado Pereira de. "Lentiviral-basead gene delivery approaches for therapeutic and functional studies in Huntington's disease.". Doutoramento, 2003. http://hdl.handle.net/10316/571.

Propriedade Intelectual

Patente
  1. Alves Sandro; Cartier-lacave Nathalie; Pereira De Almeida Luis; Nobrega Clévio; Mendonça Liliana. 2019. "EXPRESSION VECTOR FOR CHOLESTEROL 24-HYDROLASE IN THERAPY OF POLYGLUTAMINE REPEAT SPINOCEREBELLAR ATAXIAS".
  2. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado; CALDEIRA MARTINS, Teresa Maria. 2013. "HUMAN PAPILLOMAVIRUS DETECTION KIT AND ASSAY".

Outros

Outra produção
  1. Stage-dependent biomarker changes in spinocerebellar ataxia type 3. Annals of Neurology. 2023. Faber, J.; Berger, M.; Carlo, W.; Hübener-Schmid, J.; Schaprian, T.; Santana, M.M.; Grobe-Einsler, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85159405018&partnerID=MN8TOARS.
    10.1101/2023.04.21.23287817
  2. Polyglutamine disorders preface. 2018. Nóbrega, Clévio; Almeida, Luís Pereira de. http://hdl.handle.net/10400.1/11962.
    10.1007/978-3-319-71779-1
  3. CRISPR/CAS9 : uma ferramenta de edição genética para investigação e novas terapias. Monografia realizada no âmbito da unidade Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Os crescentes avanços na área da terapia génica têm revolucionado a maneira de pensar sobre tudo o que nos rodeia, particularmente na área da saúde. O sistema CRISPR/Cas9 (clustered regularly short palindromic repeats-CRISPR a. 2016. Almeida, Luís Pereira de. http://hdl.handle.net/10316/42065.
  4. Produção e purificação de vetores virais adeno-associados para terapia génica. Monografia realizada no âmbito da unidade Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A terapia génica apresenta-se atualmente como uma tecnologia em saúde muito inovadora e atrativa pelo facto de recorrendo à utilização de ácidos nucleicos se propor a cura de doenças mediante intervenção nas sua causas molecul. 2016. Almeida, Luís Pereira de. http://hdl.handle.net/10316/40905.
  5. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease. Machado–Joseph Disease (MJD) is the most prevalent autosomal dominantly inherited cerebellar ataxia. It is caused by an expanded CAG repeat in the ATXN3 gene, which translates into a polyglutamine tract within the ataxin-3 protein. Present treatments are symptomatic and do not prevent disease progression. As calpain overactivation has been shown to contribute to mutant ataxin-3 proteolysis, transl. 2014. Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Almeida, Luís Pereira de. http://hdl.handle.net/10316/28131.
  6. Transplante de células estaminais em doenças neurodegenerativas. Monografia realizada no âmbito da unidade curricular de acompanhamento do mestrado integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. As células estaminais têm a capacidade de se dividir por longos períodos de tempo mantendo a pluripotência ou a capacidade de se diferenciar em células especializadas. Estas propriedades únicas permitiram demonstrar. 2013. Almeida, Luís Pereira de. http://hdl.handle.net/10316/32313.
  7. Transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function, and painful diabetic neuropathy in diabetic type 1 mouse model. Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2014-06-30T16:31:44Z No. of bitstreams: 1 Guimaraes ET Transplantation of stem...pdf: 574490 bytes, checksum: cb2ac8ad891c02084df0111c081748e4 (MD5). Made available in DSpace on 2014-06-30T16:31:45Z (GMT). No. of bitstreams: 1 Guimaraes ET Transplantation of stem...pdf: 574490 bytes, checksum: cb2ac8ad891c02084df0111c081748e4 (MD. 2013. Guimarães, Elisalva Teixeira; Cruz, Gabriela da Silva; Almeida, Tiago Farias de; Souza, Bruno Solano de Freitas; Kaneto, Carla Martins; Vasconcelos, Juliana Fraga; dosSantos, Washington Luis Conrado; et al. https://www.arca.fiocruz.br/handle/icict/7854.
  8. Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment. The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RN. 2013. Costa, Pedro M.; Cardoso, Ana L.; Mendonça, Liliana S.; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Simões, Sérgio; et al. http://hdl.handle.net/10316/25539.
    10.1038/mtna.2013.30
  9. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease. Machado–Joseph disease is the most frequently found dominantly-inherited cerebellar ataxia. Over-repetition of a CAG trinucleotide in the MJD1 gene translates into a polyglutamine tract within the ataxin 3 protein, which upon proteolysis may trigger Machado–Joseph disease. We investigated the role of calpains in the generation of toxic ataxin 3 fragments and pathogenesis of Machado–Joseph disease.. 2012. Simões, Ana T.; Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos Bandeira; Almeida, Luís Pereira de; et al. http://hdl.handle.net/10316/28114.
    10.1093/brain/aws177
  10. Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm. Due to the differences in the oncogenic activity of human papillomaviruses (HPV), it is clinically important to accurately identify HPV types in a simple and time effective manner.Objectives. http://www.sciencedirect.com/science/article/B6VJV-4S02TKJ-2/1/5a54ef7bf4a02ab8ce983fc89b77b87f. 2008. Nobre, Rui Jorge; Almeida, Luís Pereira de; Martins, Teresa C.; de Almeida, Luís Pereira. http://hdl.handle.net/10316/5836.
    10.1016/j.jcv.2007.11.021
  11. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Machado-Joseph disease (MJD) is a fatal, dominant neurodegenerative disorder. MJD results from polyglutamine repeat expansion in the MJD-1 gene, conferring a toxic gain of function to the ataxin-3 protein. In this study, we aimed at overexpressing ataxin-3 in the rat brain using lentiviral vectors (LV), to generate an in vivo MJD genetic model and, to study the disorder in defined brain regions: s. 2008. Alves, Sandro; Régulier, Etienne; Nascimento-Ferreira, Isabel; Hassig, Raymonde; Dufour, Noelle; Koeppen, Arnulf; Carvalho, Ana Luísa; et al. http://hdl.handle.net/10316/12710.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/02/09 Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02/07 In vitro drug-mediated modulation of stem cell migration and differentiation for improved cell replacement strategies 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02/07 Brain-targeted liposomes encapsulating a differentiationinducing drug enhance neural differentiation of human iPSCderived neuroepithelial stem cells 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 Gene therapy for Brain disorders: the case of Machado-Joseph disease (Keynote Speaker) The 14th International Symposium of Gunma University Initiative for Advanced Research (GIAR) - Gene Therapy for Brain Diseases
Gunma University Showa - GIAR Viral Vector (Showa-machi Maebashi, Gunma, Japão)
2024/02 Extracellular vesicles delivery of CRISPR-Cas9 RNPs for therapeutic gene editing in Spinocerebellar Ataxia Type 3 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Spinocerebellar Ataxia Type 3 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 iPSC-Derived neuronal cells to model Fatal Familial Insomnia 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 CARHSP1, a stress granule component, as a potential therapeutic approach to Spinocerebellar ataxia type 3 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 Hacking biology: optimizing AAV-based gene delivery for enhanced brain region-specific targeting 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2024/02 Generation of lentiviral-based mouse models of spinocerebellar ataxias: where to target? 54th Meeting of the Portuguese Society of Pharmacology (SPF2024)
(Lisbon, Portugal)
2023/11 Gene therapy: new advances and future challenges. (Invited Speaker) Targeting molecular mechanisms underlying neurodegeneration: focus on advanced therapies
ESN-ISN Neurochemistry School (Faro, Algarve, Portugal)
2023/10 Generating induced pluripotent stem cell-derived cerebellar neuronal progenitors for cell transplantation in Machado-Joseph Disease ETRS & SPCE-TC 2023 Joint Annual Meeting
(Coimbra, Portugal)
2023/03 Understanding the Mechanisms of Blood-Brain Barrier Dysregulation in Machado-Joseph Disease. Congresso Anual SPDMov 2023
2023/02 Cerebellar Neuronal Pregenitors for cerebellar transplantation in Machado-Joseph Disease 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Portugal)
2023/02 Pharmacological modulation of migration and neuronal differentiation of IPSC-derived neuroepithelial stem cells. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology
2023/02 Mesenchymal Stromal Cells Alleviate Autophagy and Mitochondria Dynamics Alterations in Machado-Joseph Disease Models. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2023/02 Investigating the clock components and circadian activity in the YAC-MJD mouse model. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2023/02 Plasma-derived extracellular vesicles from Machado-Joseph Disease/Spinocerebellar Ataxia type 3 ataxic patients are enriched in mitochondrial, nuclear and nucleolar small RNA species. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2023 Isolation of natural and biologically active EV-AAVs for brain gene delivery. 26th Annual Meeting of the American Society of Gene and Cell Therapy
American Society of Gene and Cell Therapy (Los Angeles (CA), Estados Unidos)
2023 Let's make a puzzle: unravelling how Mesenchymal Stromal Cells decrease mutant ataxin-3 levels and promote ameliorations in Machado-Joseph Disease? DCV.talks – Departamento das Ciências e da Vida (DCV)
Departamento das Ciências e da Vida (DCV) (Coimbra, Portugal)
2023 Induction of mutant atxin-3 uptake, and late autophagy and mitophagy improvements may contribute to reduction of mutant ataxin-3 levels in Spinocerebellar Ataxia Type-3 models. FENS Regional Meeting
(Algarve, Portugal)
2023 Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems to treat Machado-Joseph Disease. (Paper presentation) 2023 CAG Triplet Repeat Disorder -Gordon Research Conference
Gordon Research
2022/12 Mesenchymal Stem Cells for Brain Disorders: the Particular case of Machado-Joseph Disease. Gene and Cell Therapy Curricular Unit from the Biomedical Sciences Graduation - Online Event
Biomedical Sciences Graduation - Algarve University (Algarve, Portugal)
2022/11 Intranasal delivery of Extracellular Vesicles carrying silencing sequences alleviates Spinocerebellar Ataxia Type 3 (SCA3). International Congress for Ataxia Research (ICAR)
(Dallas, Texas, Estados Unidos)
2022/10 MicroRNAs at the cornerstone of Machado-Joseph Disease pathogenesis: Leveraging disease-associated miRNA dysregulation to develop microRNA-based therapeutics. 4th meeting of the CIBB thematic area "Innovative Therapies"
CIBB (Coimbra, Portugal)
2022/10 Therapeutic strategies for spinocerebellar ataxia type 3 (Invited Speaker) 32nd Annual NECTAR Meeting 2022
European Network for CNS transplantation. American School of Classical Studies in Athens - Cotsen Hall (Athens, Grécia)
2022/07 Extracellular communication in the brain through functional transfer of CRE ExRNA. Extracellular Vesicles Gordon Research Seminar & Conference
(Maine, Estados Unidos)
2022/06 Extracellular Vesicles packaging and delivery of silencing sequences to alleviate a brain disorder 27th European Society for Animal Cell Technology (27th ESACT)
European Society for Animal Cell Technology (Lisbon, Portugal)
2022/06 Gene Therapy: from gene addition to gene editing. (Invited Speaker) World Health Summit - Regional Meeting
World Health Summit (Rome, Itália)
2022/05 Optimal recovery of brain-derived extracellular vesicles 28th Porto Cancer Meeting
(Porto, Portugal)
2022/05 Extracellular Vesicles carrying silencing sequences alleviate Machado-Joseph Disease. International Society for Extracellular Vesicles (ISEV2022)
International Society for Extracellular Vesicles (Lyon, França)
2022/05 Extracellular communication in the brain through functional transfer of Cre ExRNA. Porto Cancer Meeting (PCM2022)
(Porto, Portugal)
2022/05 Spinocerebellar ataxia type 3: from mechanism to therapy. (Invited Speaker) Sheffield Institute for Translational Neuroscience (SITraN) and Gene Therapy Innovation and Manufacturing Centre (GTIMC)
Sheffield Institute for Translational Neuroscience (SITraN) (Sheffield, Reino Unido)
2022/04 Non-invasive delivery of the brain-targeting AAV-PHP.eB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Spinocerebellar Ataxia type 3: a promising therapeutic strategy. SPDMov 2022
(Luso, Portugal)
2022/02 Reverting dysregulation of microRNA levels as a promising therapeutic strategy for Machado-Joseph Disease 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Induced Pluripotent Stem cells derived from Machado-Joseph Disease patients as a promising model to investigate microRNA dysregulation. 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022
Sociedade Portuguesa de Farmacologia (Porto)
2022/02 Assessing The Potential of Mesenchymal Stromal Cells For Alleviation Of Blood-Brain Barrier Dysfunction In Machado-Joseph Disease 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Validation of the brain-targeting AAV- PHPeB enconding cholesterol hydroxylase CYP46A1 as a therapeutic candidate for Spinocerebellar Ataxia Type-3. 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization Strategies. 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Extracellular vesicles-mediated delivery of CRISPR/Cas9 systems for therapeutic genome editing. 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Intranasal delivery of Extracellular Vesicles carrying silencing sequences alleviates Machado-Joseph Disease (MJD). 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/02 Correction of ATXN3-CAG expansion in MJD patient-derived iPSC by CRISPR/Cas9 homology-directed repair. 52ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2022/01 Extracellular Vesicles carrying engineered miRNAs alleviate Machado-Joseph Disease (MJD). Programme in Experimental Biology and Biomedicine (BEB day)
(Coimbra, Portugal)
2022 Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair 26th Annual Portuguese Society of Human Genetics Meeting
Portuguese Society of Human Genetics (Coimbra, Portugal)
2022 Engineered nucleases targeting the ATXN3 gene for the therapy of Machado-Joseph disease. Flash Talk Presentation 27th European Society for Animal Cell Technology Meeting (ESACT2022)
European Society for Animal Cell Technology (Lisbon, Portugal)
2021/12 Non-pathogenic viral vectors pseudotyped with the SARS-CoV-2 S protein to study drug repurposing and immunization strategies. CIBB Annual Meeting
CIBB (Coimbra, Portugal)
2021/09 Extracellular vesicles: a promising delivery system for silencing sequences to treat Machado-Joseph Disease. PNEV Meeting 2021
I3S (Porto, Portugal)
2021/09 Extracellular communication mediated by EVs in mouse brain. PNEV Meeting 2021
I3S (Porto, Portugal)
2021/07 Endogenous striatum derived EVs distribution within the mouse brain. Virtual conference SNEV2021
2021/07 Biomarkers for Machado-Joseph Disease: microRNAs in plasma-derived extracellular vesicles as potential candidates. Student Network on Extracellular Vesicles International Online Conference
2021/07 Gene therapy for Brain disorders: the case of Machado-Joseph disease. (Invited Speaker) II International Meeting of the Portuguese Society of Genetics
Portuguese Society of Genetics
2021/06 Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI) – Online Event
European Society of Clinical Investigation (ESCI)
2021/05 Outreach of striatum derived EVs in the mouse brain Virtual conference ISEV2021
2021/05 Gene therapy for CNS using AAVs: a perspective from the Portuguese research. (Invited Speaker) Committee of Advanced Therapies (CAT) meeting
Committee for Human Medicinal Products (CHMP)
2021/02 iPSC-derived neuroepithelial stem cells depleted for mutant ataxin-3 for Machado-Joseph disease treatment. LI Annual meeting of the Portuguese Pharmacology Society, XXXIX Clinical Pharmacology meeting and XX meeting of Toxicology
Portuguese Society of Pharmacology (Portugal)
2021/02 Unravelling dysregulated micrornas in a transgenic mouse model of Machado-Joseph disease. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02 Identification of dysregulated mirnas in human induced pluripotent stem cell-based models of Machado-Joseph disease: one step closer to a therapeutic approach? 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02 Importin-8 Silencing Prevents Mutant Ataxin-3 Aggregation And Delays Machado-Joseph Disease Progression. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02 Brain microRNAs in plasma-derived extracellular vesicles as potential biomarkers for Machado-Joseph Disease 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02 Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02 Phenotypic characterization of a relevant model of Machado-Joseph disease: The YAC-MJD mouse model 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021 Extracellular vesicles- mediated delivery of CRISPR/Cas9 tools to treat Machado-Joseph Disease - Paper presentation 1st Meeting of the Portuguese Network on Extracellular Vesicles
2021 Phenotypic characterization of neuronal cultures derived from Machado-Joseph disease induced pluripotent stem cells 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2020/11 Whole-Brain Biodistribution Analysis of Adeno-Associated Virus (AAV) with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy.
Virtual Early Career European Microscopy Congress 2020
2020/11 Whole-Brain Biodistribution Analysis of Adeno-Associated Virus (AAV) with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy. Virtual Early Career European Microscopy Congress 2020
2020/09 Predictors of quality of life in Machado-Joseph disease: a longitudinal observation study. The Movement Disorder Society Virtual Congress
2020/04 Blood-based biomarkers for Machado-Joseph disease: extracellular vesicles RNA profile & serum protein array. ESMI final meeting. Videoconference
ESMI
2020/03 Autophagy-lysosome pathway in neurodegenerative disease: the case of Machado-Joseph disease. (Invited speaker) American Society of Experimental Neurotherapeutics Annual Meeting (ASENT)
American Society of Experimental Neurotherapeutics (ASENT) (Bethesda, Maryland, Estados Unidos)
2020/03 Preconditioning mice with osteosarcoma cells-derived secretome promote tumour cells engraftment and lung metastasis development. EACR-AACR-ASPIC Basic and Translational Research Conference – Tumor Microenvironment
EACR-AACR-ASPIC (Lisbon, Portugal)
2020/03 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Department of Life Sciences Seminars Series in Coimbra
Department of Life Sciences - Coimbra (Coimbra, Portugal)
2020/02/02 Establishment and characterization of human pluripotent stem cells derived brain organoids. L Annual meeting of the Portuguese Pharmacology Society, XXXVIII Clinical Pharmacology meeting and XIX meeting of Toxicology
Portuguese Society of Pharmacology (Portugal)
2020/02 Human IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph Disease. L Annual meeting of the Portuguese Pharmacology Society, XXXVIII Clinical Pharmacology meeting and XIX meeting of Toxicology
Portuguese Society of Pharmacology (Portugal)
2020/02 CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo. L Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02 Proteomic identification of a set of serum proteins with potential to be used as biomarkers for Machado-Joseph Disease. L Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02 Extracellular Vesicles for treatment of Machado-Joseph Disease. L Annual meeting of the Portuguese Pharmacology Society, XXXVIII Clinical Pharmacology meeting and XIX meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020 Permanent Inactivation of the ATXN3 Gene: A Possible Therapeutic Approach for Machado-Joseph Disease. 24th Annual meeting of the Portuguese Society of Human Genetics (SPGH 2020). Virtual meeting
Portuguese Society of Human Genetics (Portugal)
2019/12 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
(Coimbra, Portugal)
2019/11 Genetic Therapies for MJD (Keynote Speaker) International MJD Research Conference
(Washington DC, USA, Estados Unidos)
2019/11 Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy. 2019 Spanish & Portuguese Advanced Optical Microscopy Meeting (SPAOM 2019)
(Coimbra, Portugal)
2019/11 A New Clearing Method for Whole-Brain Imaging with Single-Cell Resolution - Invited speaker at workshop 2019 Spanish & Portuguese Advanced Optical Microscopy Meeting (SPAOM 2019)
(Coimbra, Portugal)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. 2019 International Machado-Joseph Research Disease Conference
(Washington, DC, Estados Unidos)
2019/11 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. International Research Ataxia Conference (IARC) 2019
(Washington, DC, Estados Unidos)
2019/11 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/11 Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/11 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease. Flash Talk Presentation. International Ataxia Research Conference (IARC 2019)
(Washington, DC, Estados Unidos)
2019/11 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease. 2019 International Machado-Joseph Research Disease Conference
(Washington, DC, Estados Unidos)
2019/11 miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls. 23rd Annual Meeting of the Portuguese Society of Human Genetics
Portuguese Society of Human Genetics
2019/11 Machado-Joseph Disease: the role of ageing in polyglutamine-induced neurodegeneration. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/11 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases. (Flash poster presentation) 5th GEIVEX Symposium
(Granada, Espanha)
2019/11 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders. 1st Annual Meeting in Pharmaceutical Sciences
Pharmacy Faculty of UC (Coimbra, Portugal)
2019/10 Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy - Flash Talk Presentation EMBO | EMBL Symposium: Seeing Is Believing – Imaging the Molecular Processes of Life
EMBO | EMBL (Heidelberg, Alemanha)
2019/10 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Lisbon, Portugal)
2019/06 Machado Joseph disease animal models. Session Understanding human disease through animal models (Invited speaker) European Human Genetics Conference
European Human Genetics (Gothenburg, Sweden, Suécia)
2019/06 Generation and characterization of advanced models of SCA-3: patients-derived iPSCs cells. 4ª reunião anual do consórcio europeu JPND-Model PolyQ
Consórcio europeu JPND-Model PolyQ (Roma, Itália)
2019/05 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: Results from mouse and human brain tissues. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05 Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05 CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05 Permanent inactivation of the ATXN3 gene: A possible therapeutic approach for Machado-Joseph disease. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05 Characterization and follow-up of the Coimbra cohort of Machado-Joseph Disease Patients. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05 Intersection of autophagy and exosome secretion on alpha-synuclein spreading pattern in in vitro models of Parkinson's disease 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/02 Characterization of a trial-ready cohort of Machado-Joseph disease patients: status update. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 Extracellular Vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 HUMAN IPSC-DERIVED NEUROEPITHELIAL STEM CELLS FOR NEUROPROTECTION AND NEUROREGENERATION IN MACHADO-JOSEPH DISEASE. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 EXOSOMES AS A DELIVERY SYSTEM FOR MIRNAS IN MACHADO-JOSEPH DISEASE. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 SIRTUIN 2 DEFICIENCY TRIGGERS HEPATIC LIPID ACCUMULATION THROUGH ER STRESS-DEPENDENT PATHWAY. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 CYP46A1 OVEREXPRESSION ALLEVIATES MACHADO-JOSEPH DISEASE XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 MUTANT ATAXIN-3 SPREADING IN MACHADO-JOSEPH DISEASE. XLIX Reunião da Sociedade portuguesa de Farmacologia; XXXVII Reunião de Farmacologia Clínica; XVIII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02 CHARACTERIZATION OF A TRIAL-READY PORTUGUESE COHORT OF MACHADO-JOSEPH DISEASE PATIENTS: STATUS UPDATE XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019 Disruption of Blood-Brain Barrier in Machado-Joseph Disease. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019 A miRNA-based gene therapy approach to knock-down mutant ATXN3: Alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019 Autophagy Activation Induced By Let-7 Microrna Overexpression Counteracts Disease Phenotype In Machado-Joseph Disease Mouse Models. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019)
Portuguese Society for Neuroscience (Lisbon, Portugal)
2018/12 Terapia Génica: os medicamentos do futuro
Rotary Club de Coimbra (Coimbra, Portugal)
2018/10 Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease Conference on Changing the Face of Modern Medicine - Stem Cell and Gene Therapy European Soc Gene & Cell Therapy
Int Soc Stem Cell Res; French Soc Gene & Cell Therapy (Lausanne, Suiça)
2018/10 Patient-specific iPSC-derived neuroepithelial stem cells for neuroprotection and neuroregeneration in Machado-Joseph disease.
10th International Symposium on Neuroprotection and Neurorepair (Dresden, Alemanha)
2018/09 Em que ponto estamos na investigação da doença de Machado-Joseph ?
APAHE (Chamusca, Portugal)
2018/09 Vectores para Terapia Personalizada. Seminário Seat & Seed
Centro Hospitalar Universitário de Coimbra CHUC (Coimbra, Portugal)
2018/07 Non-invasive and allele-specific gene silencing therapy for Machado-Joseph disease. 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
(Kyoto, Japão)
2018/07 Editing ATXN3 CAG repeat region using CRISPR-Cas9. 3nd JPND ModelPolyQ Meeting
JPND
2018/07 Generation and characterization of advanced models of SCA-3 patients-derived iPSCs cells and animal approaches. 3nd JPND ModelPolyQ Meeting
2018/07 Neuropeptide Y rescues aging phenotype of human Hutchinson-Gilford Progeria syndrome fibroblasts. 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
(Kyoto, Japão)
2018/06 Neurodegenerative diseases: From common mechanisms to promising therapies. (Invited Speaker) Workshop on Integrative approaches in Neurodegeneration
JPND programme - Faculty of Sciences University of Lisbon ( Lisbon, Portugal , Portugal)
2018/05 Non-invasive brain delivery of hybrid extracellular vesicles for therapy of Machado-Joseph Disease (MJD). Annual Meeting ISEV2018
(Barcelona, Espanha)
2018/02 From autophagy modulation to extracellular vesicles secretion in Machado-Joseph disease. (Invited Speaker) 1st Meeting on Vesicular Biology
(Coimbra, Portugal)
2018/02 Das causas da doença de Machado-Joseph ao seu tratamento. (Invited Speaker) Workshop Doença de Machado-Joseph: do Laboratório para a sociedade.
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2018/02 Protocol for the characterization of CAG tract and flanking polymorphisms in polyQ disorders: impact on the diagnosis and in the development of gene-based therapies. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 CRISPR-Cas9-mediated pre- transcriptional silencing of mutant ataxin-3. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia
2018/02 Characterization of a trial-ready Portuguese cohort of Machado-Joseph disease patients. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 AAV-Based Tools For The Development Of Cellular And Animal Models Of Machado-Joseph Disease. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 Pharmacological targeting of AMPK signaling pathway as a therapeutic approach to polyglutamine diseases. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 Hybrid vesicles: a promising therapeutic approach for MJD. 1st Meeting on Vesicular Biology
(Coimbra, Portugal)
2018/02 Cerebrovascular and Blood-brain Barrier Impairments in Machado-Joseph Disease. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/02 Generation of a Machado-Joseph disease isogenic control induced pluripotent stem cell line. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia
2018/02 Ibuprofen decreases neuroinflammation and improves neuropathology and motor impairments in Machado-Joseph disease. XLVIII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXVI Reunião De Farmacologia Clínica, XVII Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2018/01 Non-invasive gene therapy of the brain. (Invited Speaker) XII Spanish-Portuguese Conference on Drug Delivery. Tailoring drug delivery systems to the patients’ needs
CRS Spanish-Portuguese Local Chapter (Coimbra, Portugal)
2018/01 Exosomes: tiny vesicles with great potential for MJD treatment. XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients' needs
(Coimbra, Portugal)
2018 Machado-Joseph disease: from mechanism to emerging therapies. (Keynote Speaker) First Dutch Scientific Ataxia Symposium
Dutch Ataxia Society (Groningen, Países Baixos)
2018 Tailoring gene editing strategies for the treatment of Machado-Joseph disease. Portuguese Society of Movement Disorders (SPDMov)
Portuguese Society of Movement Disorders (SPDMov) (Curia, Portugal)
2017/12 Gene therapy and gene editing: from promise to first successes. Rare diseases symposium,
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2017/11 Advanced models of polyglutamine disorders (HD, SCA3, SCA7). (Invited Speaker) ModelPolyQ. EU Joint Programme on Neurodegenerative disease Research JPND. Intermediate Symposium
ModelPolyQ. EU Joint Programme on Neurodegenerative disease Research JPND (Hague, Países Baixos)
2017/11 From microRNAs to gene silencing in Machado-Joseph disease. (Keynote Speaker) Workshop Highlights on Neurogenetics: Machado Joseph disease, Spastic paraplegias and Muscular Dystrophies: pathophysiology and biomarkers
Hospitais de Clinicas, Porto Alegre, Rio Grande do Sul, Brasil (Porto Alegre, Rio Grande do Sul,, Brasil)
2017/10 Human iPSCs-derived NESCs for cerebellar transplantation in Machado-Joseph disease. 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Covilhã, Portugal)
2017/06 Huntington’s disease patient-derived induced pluripotent stem cells and neural stem cells: insights into early metabolic and mitochondrial defects. The International Society for Stem Cell Research (ISSCR)
International Society for Stem Cell Research (ISSCR) (Boston, Estados Unidos)
2017/05 From neurobiology to future therapies of Machado-Joseph disease. (Invited Speaker) Annual Meeting of the JPND ESMI project
JPND ESMI project (Coimbra, Portugal)
2017/05 Interplay between autophagy and alpha-synuclein spreading in in vitro models of Parkinson’s disease. SPDMov, New Challenges in the Diagnosis and Treatment of Movement Disorders
Portuguese Society of Movement Disorders (SPDMov) (Ofir - Esposende, Portugal)
2017/04 Universidade e Ciência, Investigação e Produção Científica. Semana Cultural da Universidade de Coimbra
(Coimbra, Portugal)
2017/03 Terapias na doença de Machado-Joseph: estado da investigação. DIA DAS DOENÇAS RARAS 2017: “Com a Investigação as Possibilidades são Ilimitadas”
(Ponta Delgada, Portugal)
2017/03 Mitochondrial defects in Huntington's disease: what can we learn from patient-derived induced pluripotent and neural stem cell models? SPDMov, New Challenges in the Diagnosis and Treatment of Movement Disorders
Portuguese Society of Movement Disorders (SPDMov) (Ofir - Esposende, Portugal)
2017/03 Silencing Spinocerebellar Ataxia Type 3 trough the systemic route. SPDMov, New Challenges in the Diagnosis and Treatment of Movement Disorders
Portuguese Society of Movement Disorders (SPDMov) (Ofir - Esposende, Portugal)
2017/02 Gene editing strategies for Machado-Joseph disease. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Pre-transcriptional silencing of ataxin-3 using a CRISPR-Cas9-derived system. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 The role of microRNAs in Machado-Joseph disease: from pathogenesis to therapy. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Role of Stress Granules in Spinocerebellar Ataxias. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseph disease. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Hypothalamic ataxin-2 modulates body weight and insulin sensitivity. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Reestablishment of nuclear-mitochondrial communication as a new putative therapeutic strategy for Machado-Joseph disease. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Selective down-regulation of amygdala neuronal A2A receptors prevents behavioural modifications induced by stress. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Ghrelin ameliorates the senescent phenotype of human Hutchinson-Gilford progeria syndrome cells. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Caloric restriction stimulates autophagy in rat cortical neurons through ghrelin receptor activation. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Autophagy is stimulated by npy y1 and y5 receptors activation in hypothalamic neurons. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Mitochondrial defects in Huntington’s disease patient-derived induced pluripotent stem cells and differentiated counterparts. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Silencing MJD trough the systemic route. XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/01 Genetic manipulation in models of Machado-Joseph disease. Neuroscience and Mental Health: a clinical and molecular perspective
(Portugal)
2017/01 Gene editing strategies for Machado-Joseph disease. BEB DAY - Not So Usual Insights Into a PhD
(Coimbra, Portugal)
2017/01 Is ageing the triggering factor in polyglutamine-induced neurodegeneration? A study in Machado-Joseph disease models. BEB DAY - Not So Usual Insights Into a PhD
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2017 Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease. Brain Without Borders Meeting
(Coimbra, Portugal)
2016/12 From gene to therapeutic approaches in Machado-Joseph disease. 1st Meeting on Biomedical Research
CNC.IBILI (Coimbra, Portugal)
2016/11 Silencing Machado-Joseph disease. (Invited Speaker) Brain Without Borders Conference
(Coimbra, Portugal)
2016/11 Molecular approaches for Machado-Joseph disease.
SPGH Sociedade Portuguesa de Genética Humana (Coimbra, Portugal)
2016/11 MicroRNAs control mutant ataxin-3 expression through 3’UTR mediated regulation. Brain without Borders international Conference
(Portugal)
2016/11 Transplantation of Neural Stem Cells as a therapeutic approach in Machado-Joseph disease. Brain without Borders international Conference
(Coimbra, Portugal)
2016/11 Induced pluripotent and neural stem cells derived from Huntington´s disease patient exhibit mitochondrial and metabolic abnormalities. BRAIN WITHOUT BORDERS - modeling, disease and repair.
(Coimbra, Portugal)
2016/11 Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease. 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH)
Sociedade Portuguesa de Genética Humana (SPGH) (Coimbra, Portugal)
2016/10 The power of microRNA modulation in Alzheimer’s disease treatment. V Annual PhDOC Meeting
2016/09 Potenciais estratégias terapêuticas para impedir a progressão da Doença de Machado Joseph. (Invited Speaker) Encontro Ibérico de Ataxias Hereditárias. Partilhar para conhecer melhor
Hospitais da Universidade de Coimbra. Apahe (Coimbra, Portugal)
2016/09 Genetic approaches to fight neurodegenerative diseases. (Invited Speaker) Master Course for Systems Biomedicine - videoconference
LCSB - Luxembourg Centre for Systems Biomedicine (Luxembourg, Luxemburgo)
2016/06 From gene to therapy of Machado-Joseph disease. (Invited Speaker) 45th Annual Meeting of the Brazilian Biochemistry and Molecular Biology Society (SBBq)
Brazilian Biochemistry and Molecular Biology Society (SBBq) (Natal, RN, Brasil)
2016/06 From gene silencing to caloric restriction in neurodegeneration. (Invited Speaker)
LCSB - Luxembourg Centre for Systems Biomedicine, University of Luxembourg (Luxembourg, Luxemburgo)
2016/06 Inhibition of calpain-mediated proteolysis of mutant ataxin-3 as a therapeutic approach in Machado-Joseph Disease. "Advanced therapies" Course from BEB PhD Programme
BEB PhD Programme (Coimbra, Portugal)
2016/06 MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease. The 2016 Alzheimer’s Disease Congress
(London, Reino Unido)
2016/05 NPY reverts HGPS phenotype. 8th Progeria Research Foundation International Scientific Workshop – Across the Table, Around the Globe
Progeria Research Foundation (Cambridge, Estados Unidos)
2016/04 Transplantation of Neural Stem Cells as a therapeutic strategy in Machado- Joseph disease. 6th Ataxia Investigators Meeting (AIM)
(Orlando, FL, Estados Unidos)
2016/03 Molecular therapy approaches for Machado-Joseph disease. (Invited Speaker) Machado-Joseph disease Symposium: Where do we stand? The 10th World Congress on Controversies in Neurology (CONy)
World Congress on Controversies in Neurology (CONy) (Lisbon, Portugal, Portugal)
2016/03 Trehalose reverses the phenotype of Machado-Joseph disease models. Machado-Joseph disease Symposium: Where do we stand? The 10th World Congress on Controversies in Neurology (CONy)
World Congress on Controversies in Neurology (CONy) (Lisbon, Portugal)
2016/03 Evaluation of the potential of Neural Stem Cells transplantation as a therapeutic strategy in Machado-Joseph disease. Machado-Joseph disease Symposium: Where do we stand? The 10th World Congress on Controversies in Neurology (CONy)
World Congress on Controversies in Neurology (CONy) (Lisbon, Portugal)
2016/02 Phosphorylation of ataxin-3 decreases neuronal defects in Machado-Joseph disease models. . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Trehalose reverses disease phenotype in both in vitro and in vivo models of Machado-Joseph disease transgenic mice. . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Post-transcriptional regulation of ataxin-3 – A role for microRNAs. . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Sustainable alleviation of motor impairmenst and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in Machado-Joseph disease. . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2016/02 CORDYCEPIN: a pharmacological approach to modulate mutant ataxin-3 and it use as a potential therapeutic effect in Machado Joseph-disease
(Porto, Portugal)
2016/02 Hypothalamic ataxin-2 contributes to energy balance regulation and metabolism. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Autophagy activation prevents alpha-synuclein secretion in exosomes. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 MODULATION OF INSULIN SENSITIVITY BY HYPOTHALAMIC SIRTUIN 2. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Hypothalamic let-7 microRNA as a novel anti-obesity target in mice. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016/02 Silencing Machado-Joseph disease trough the systemic route. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2016 MicroRNA mediated gene silencing in neurodegenerative diseases. "Advanced therapies" Course from BEB PhD Programme
BEB PhD Programme (Coimbra, Portugal)
2016 Neuropeptide Y rescues the aging phenotype of Human Hutchinson-Gilford Progeria syndrome cells. XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2015/12 Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph Disease. XIII Annual Meeting of Center for Neuroscience and Cell Biology of Coimbra
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2015/12 MicroRNA modulation targets amyloid-ß cascade in Alzheimer’s disease XIII Annual CNC Meeting
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2015/12 Non-viral silencing of Machado-Joseph disease after intravenous administration. XII CNC Meeting; Coimbra
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Coimbra, Portugal)
2015/11 Molecular approaches to block or modify neurodegeneration in Machado-Joseph disease. (Invited Speaker)
Centre for Neuroscience, Indian Institute of Science (Bangalore, Índia)
2015/11 Gene and Stem Cell Therapies for Brain disorders: the case of Machado-Joseph disease. (Invited Speaker) Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Endocrinology and Neurosciences
(Covilhã, Portugal)
2015/10 Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease. Annual Meeting of the Portuguese Society of Stem Cells and Cell Therapy
Portuguese Society of Stem Cells and Cell Therapy (Oeiras, Portugal)
2015/09 Activating autophagy prevents alpha-synuclein secretion in exosomes. First Iberian Meeting on Extracellular Vesicles
(Porto, Portugal)
2015/08 From gene therapy to autophagy activation as therapeutic strategies for Machado-Joseph disease. (Invited Speaker) International Conference on Machado Joseph Disease (MJD)
(Cairns, Austrália)
2015/08 Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons. 11th NPY-PYY-PP International Meeting
(Leipzig, Alemanha)
2015/07 Dissecting the role of microRNAs and their therapeutic potential in Alzheimer's disease (fire talk). FEBS Young Scientists Forum (YSF)
(Berlin, Alemanha)
2015/06 New models for study of nervous system disease mechanisms: human inducible pluripotent stem cells. Genetics of Intellectual Disability – an update
(Braga, Portugal)
2015/06 The triad of behavioural modifications characteristic of depression is abrogated by the selective amygdala neuronal down-regulation of adenosine A2A receptors. XIV Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Póvoa de Varzim, Portugal)
2015/05 Non-viral silencing of Machado-Joseph disease through the systemic route. ASGCT 18th Annual Meeting
ASGCT (New Orleans, Estados Unidos)
2015/04 Molecular translational research in neurodegenerative diseases. Meeting of the Health Cluster Portugal
(Coimbra, Portugal)
2015/04 The therapeutic potential of microRNAs in Alzheimer’s disease. European Neuroscience Conference by Doctoral Students for Doctoral Students 2015 (ENCODS 2015)
(Sesimbra, Portugal)
2015/03 Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph disease. International Ataxia Research Conference (IARC 2015)
(Old Windsor, Reino Unido)
2015/02 Machado-Joseph disease: from gene silencing to protein clearance. (Invited Speaker) Final Meeting of the TreatPolyQ Industrial Training Network
TreatPolyQ Industrial Training Network (Coimbra, Portugal)
2015/02 MicroRNA pathway dysfunction and let7/lin28 alterations in obesity: implications in hypothalamic neurogenesis XLV Annual Meeting of the Portuguese Pharmacological Society
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2015 Ataxin-3 3'UTR reduces neuropathology in a lentiviral mouse model of MJD - A role for microRNAs? EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification"
EMBO | EMBL (França)
2015 Transplantation of cerebellar neural stem cells alleviates motor coordination and neuropathological deficits of a transgenic mouse model of Machado-Joseph disease. International Ataxia Research Conference (IARC 2015)
(Windsor, Reino Unido)
2015 Identification of the calpain cleavage sites in ataxin-3 protein. International Ataxia Research Conference (IARC 2015)
(Windsor)
2015 Neuropeptide Y alleviates neuropathological and behavioral abnormalities in mice models of Machado-Joseph Disease. XLV Annual Meeting of the Portuguese Pharmacological Society
Portuguese Society of Pharmacology (Lisbon, Portugal)
2014/11 Cerebellar Neural Stem Cells Transplantation in Machado-Joseph disease. (Invited Speaker) Presentation to the press at the Society for Neurosciences Meeting
Society for Neurosciences (Washington D.C, Estados Unidos)
2014/11 Terapia génica da Doença de Machado-Joseph. VIII Congresso Científico NEF/AAC- "Cérebro e (dis)funções"
(Coimbra, Portugal)
2014/11 Transplantation of Neural Stem Cells Improves Motor Coordination, Neuropathology in Mouse Model of Machado-Joseph Disease. Society for Neuroscience's annual meeting
Society for Neurosciences (Washington, DC, Estados Unidos)
2014/10 Doença de Machado-Joseph: do mecanismo à terapia. (Invited Speaker) 18º Encontro de Ataxias da ABAHE
Abahe - Associação Brasileira de Ataxias Hereditárias e Adquiridas (Taubaté, Brasil)
2014/10 Insights from Machado-Joseph disease transgenic mice may lead to new therapeutic approaches. (Invited Speaker) Invited Seminar
Hospital de Clínicas de Porto Alegre, Univ. Fed. do Rio Grande do Sul (Porto Alegre, Rio Grande do Sul, Brasil)
2014/10 From mechanism to therapy of the polyglutamine Machado-Joseph Disease. (Invited Speaker) Invited Seminar
University of Campinas (Campinas, Brasil)
2014/09 Pharmacological activation of autophagy to alleviate Machado-Joseph disease. (Invited Speaker) Dia Nacional do Farmacêutico 2014 - Comemorações
Ordem dos Farmacêuticos (Coimbra, Portugal)
2014/05 From Mechanism to Therapy of the polyglutamine Machado-Joseph disease. (Invited Speaker) Invited Seminar at Hebrew University of Jerusalem, Silberman building.
Hebrew University of Jerusalem (Jerusalem, Israel)
2014/05 Caffeine alleviates progressive motor deficits in MJD transgenic mice. 5th Ataxia Investigators Meeting (AIM)
NAF – National Ataxia Foundation (Las Vegas, Estados Unidos)
2014/04 Doença de Machado-Joseph: do mecanismo à terapia. 2nd  Annual Meeting of Coimbra Health School
(Coimbra, Portugal)
2014/03 Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target. 5th Ataxia Investigators Meeting (AIM)
(Las Vegas, Estados Unidos)
2014/03 Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease. 5th Ataxia Investigators Meeting (AIM)
(Las Vegas, Estados Unidos)
2014/02 Silencing Machado-Joseph disease. Gene-based Therapeutics for Neurological Disorders. (Invited Speaker) From Basic Science to Clinical Applications, Fiesta Americana Condesa
Fiesta Americana Condesa (Cancun, México)
2014/01 Molecular therapy approaches for Machado-Joseph disease. (Invited Speaker) Seminário UC Biotech
(Cantanhede, Portugal)
2014 Protein phosphorylation as a toxicity modulator in Machado-Joseph disease. XVIII Congress of the Portuguese Biochemical Society (SPB)
Portuguese Biochemical Society (Coimbra, Portugal)
2014 Cerebellar transplantation of mesenchymal stromal cells alleviates motor impairments and neuropathology of a transgenic mouse model of Machado-Joseph disease. Term Stem Conference
(Porto, Portugal)
2014 Mesenchymal stem cells for Machado-Joseph disease therapy. XVIII Congress of the Portuguese Biochemical Society (SPB)
Portuguese Biochemical Society (Coimbra, Portugal)
2013/10 Molecular approaches to modify Machado-Joseph disease progression. (Invited Speaker) Invited Seminar at the University of Massachussets Medical School
University of Massachussets Medical School, Gene Therapy Center,Albert Sherman Center (Worcester, Estados Unidos)
2013/07 Viral vectors for gene therapy to the brain: from animal models to gene therapy. (Invited Speaker) NEURASMUS Annual Meeting and Workshop
University of Coimbra (Coimbra, Portugal)
2013/06 Nanotechnology and nanomedicines in neurological research. (Invited Speaker) EURECNET Conference: “Research in Neurosciences: Scientific, ethical and legal challenges for review by research ethics committees”
EURECNET (Lisbon, Portugal, Portugal)
2013/05 Towards the understanding of pathological protein processing and toxicity in Machado-Joseph disease. (Invited Speaker) Meeting of the E-rare project, call 2012: European Research Projects on rare diseases driven by young investigators
European Research Projects on rare diseases driven by young investigators (Bonn, Alemanha)
2013/03 Silencing Machado-Joseph disease. IV Jornadas Nacionais de Ciências Biomédicas: Onde a Ciência move o futuro
(Aveiro, Portugal)
2013/02 Molecular therapy of Machado-Joseph disease. (Invited Speaker) TreatPolyQ Mid-Term Meeting and Training
(Paris)
2013/01 Células Estaminais Pluripotentes Induzidas.
Escola Secundária D. Maria (Coimbra, Portugal)
2012/11 Targeted treatment for Machado-Joseph disease. 16ª Reunião Anual da Sociedade Portuguesa de Genética Humana
(Porto, Portugal)
2012/11 Beclin-1 mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-joseph disease. Ataxia Research Conference
(London, Reino Unido)
2012/10 Machado-Joseph Disease: from models to progression blockage. (Invited Speaker) Neurodegenerative diseases: From molecules to clinics and beyond
(Portugal)
2012/10 Allele-specific therapies: The case of Machado-Joseph disease. (Invited Speaker) 2º Simpósio do Fórum de Pós-docs "Changing Paradigms of Science"
(Coimbra, Portugal)
2012/09 Do mecanismo à terapia da doença de Machado-Joseph disease. (Invited Speaker) Dia Internacional das Ataxias
APAHE (Coimbra, Portugal)
2012/07 From mechanism to therapy of Machado-Joseph disease. (Invited Speaker) Broad Institute; Cambridge
(Cambridge MA, Estados Unidos)
2012/04 Doenças neurodegenerativas: Mecanismos e novas abordagens terapêuticas. (Invited Speaker) Palestra na Plural
(Coimbra, Portugal)
2012/03 Disease-modifying strategies for Machado-Joseph disease. (Invited Speaker) Fourth Ataxia Investigators’ Meeting (AIM 2012), AIM 2012: Advancing Toward Therapeutics
National Ataxia Foundation NAF (Grand Hyatt San Antonio, San Antonio, Texas, Estados Unidos)
2012/03 Investigating disease-modifying strategies for Machado-Joseph disease. (Invited Speaker) Patient Information session
(Los Altos, Estados Unidos)
2012/01 From mechanism to therapy of Machado-Joseph disease. (Invited Speaker) iMM Monday Lecture
(Lisboa, Portugal)
2012 From mechanism to therapy of Machado-Joseph disease
University of Michigan, Department of Neurology (Ann Arbor, Michigan)
2012 From mechanism to therapy of neurodegenerative diseases: The case of Machado-Joseph disease. Workshop – Sinergias e Financiamento
Divisão de Apoio e Promoção de Investigação (DAPI) (Coimbra, Portugal)
2011/11 RNA interference rescues motor and neuropathological deficits in Machado-Joseph disease rodent models. Society for Neuroscience Meeting
Society for Neuroscience (Washington D.C, Estados Unidos)
2011/07 Modifying neurodegeneration in Machado-Joseph disease. (Invited Speaker)
Carey Lab, Champalimaud Foundation (Lisboa, Portugal)
2011/06 Gene Therapy to the Central Nervous System. (Invited Speaker)
(Coimbra, Portugal)
2011/02 Modifying neurodegeneration in Machado-Joseph disease. (Invited Speaker)
(Lisboa, Portugal)
2011/01 Modifying neurodegeneration in Machado-Joseph disease. (Invited Speaker)
(Lisboa, Portugal)
2010/11 Blocking neurodegeneration in Machado-Joseph disease. (Invited Speaker) MIT Portugal Program - Visiting Scholar Lecture
Massachusetts Institute of Technology - MIT (Cambridge MA, Estados Unidos)
2010/11 Modifying neurodegeneration in Machado-Joseph disease. (Invited Speaker)
Xandra Breakfield Group, Harvard Medical School (Charlestown; Boston , Estados Unidos)
2010/11 Modelling and modifying Machado-Joseph disease. (Invited Speaker)
Kaspar Lab; Nationswide Children’s Hospital (Columbus, Ohio, Estados Unidos)
2010/10 Silencing Machado-Joseph disease. (Invited Speaker)
Centre for BioNano Interactions, School of Chemistry & Chemical Biology University College Dublin (Belfield, Dublin, Irlanda)
2010/05 Silencing Machado-Joseph disease. (Invited Speaker) ENINET Final Meeting
Network of European Neuroscience Institutions (Coimbra, Portugal)
2009/12 Effects of overexpression or silencing of neuropeptide Y in the rat hypothalamic arcuate nucleus achieved by viral vector approach in feeding behaviour. XL Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2009/09 RNA interference for Machado-Joseph disease. (Invited Speaker) Jornadas Cientificas Internationales de Euro-Ataxia.
(Valladolid, Espanha)
2009/06 RNA interference for the treatment of Machado-Joseph disease: the role of endogenous wild-type ataxin-3 11th meeting of the Portuguese Society for Neurosciences
Portuguese Society for Neurosciences (Braga, Portugal)
2009/06 Regulation of body weight and eating behavior by a central neuropeptide Y gene transfer approach. PENS BLACKWELL SUMMER SCHOOL 2009 -Stress, Drug Addiction and Eating Disorders
PENS BLACKWELL SUMMER SCHOOL (Dubrovnick, Croácia)
2009/04 Inhibition of calpains in a lentiviral mouse model of Machado-Joseph disease prevents nuclear localization of mutant ataxin-3 and reduces neuronal dysfunction and degeneration. V international Workshop on Machado-Joseph disease
(S. Miguel, Azores, Portugal)
2009/04 RNA interference for the treatment of Machado-Joseph disease: the role of endogenous wild-type ataxin-3. V international Workshop on Machado-Joseph disease
(S. Miguel, Azores, Portugal)
2009/04 Neuroprotective effects mediated by the autophagy-related protein BECLIN-1 in a lentiviral-based rat model of Machado-Joseph disease. V international Workshop on Machado-Joseph disease
(S. Miguel, Azores, Portugal)
2009/04 Gene transfer approach for the study of the adenosine A2A receptors role in Machado Joseph disease V international Workshop on Machado-Joseph disease
(S. Miguel, Azores, Portugal)
2009/04 Doenças neurodegenerativas e envelhecimento: o modelo da doença de Machado-Joseph. (Invited Speaker) V Ciclo de Conferências do Instituto de Ciências da Saúde do Norte (ISCS-N)
(Porto, Portugal)
2009/04 Terapia celular e terapia génica do sistema nervoso central. (Invited Speaker) XIV Simpósio NEF/AAC, Biotecnologia nas Ciências da Saúde
(Coimbra, Portugal)
2009/03 Human papillomavirus detection Kit. Healthcare Biotech Forum
(Rome, Itália)
2009/01 Human papillomavirus detection Kit. i-techpartner Growth Academy
i-techpartner Growth Academy (Coimbra, Portugal)
2008/12 Gene transfer approach for the study of the adenosine A2A receptors role in Machado-Joseph disease. VI Annual Meeting of CNC & Annual Meeting of the Doctoral Programme in Experimental Biology and Biomedicine
CNC- Centro de Neurociências e Biologia Celular da Universidade de Coimbra - Biocant Park (Cantanhede, Portugal)
2008/10 Silencing Neuropeptide Y in the CNS: the AAV-microRNA tool-kit. XVI Congress of Biochemistry
University of Azores (Ponta Delgada, Azores, Portugal)
2008/09 A lentiviral rat model of Machado-Joseph disease. (Invited Speaker) Friday noon seminars
(Porto, Portugal)
2008/06 Diagnostic Kit for complete genital Human papillomavirus genotyping. The Medtech Forum
(Coimbra, Portugal)
2008/01 Diagnostic Kit for Genital Human Papillomavirus typing. Idea Spring 2008 – MIT program
MIT program - Biocant (Cantanhede, Portugal)
2008/01 Gene Therapy as a strategy of delivery to the Central Nervous System: from animal models of disease to therapies. (Invited Speaker)
(Coimbra, Portugal)
2007/12 Complete genotyping of mucosal Human papillomavirus in Portuguese population using a novel PCR-RFLP methodology and an original algorithm. Encontro anual do Centro de Neurociências e Biologia Celular 2007
CNC- Centro de Neurociências e Biologia Celular da Universidade de Coimbra (Coimbra, Portugal)
2007/12 siRNA delivery to the Central Nervous System: Tf-lipoplex-mediated gene silencing in vitro and in vivo. V Encontro anual do Centro de Neurociências e Biologia Celular 2007
CNC- Centro de Neurociências e Biologia Celular da Universidade de Coimbra (Coimbra - Bencanta, Portugal)
2007/09 Viral vectors for gene transfer to the Central Nervous System: from animal models of disease to therapy. (Invited Speaker)
(Lisboa, Portugal)
2007/07 Viral vectors for modeling polyglutamine disorders. (Invited Speaker) Novel Molecular Strategies to treat Neurodegenerative Diseases
PENS Summer School (Ofir - Esposende, Portugal)
2007/04 Viral vectors for gene transfer to the Central Nervous System. (Invited Speaker) Encontro de Ciência em Portugal
(Lisboa, Portugal)
2006/12 Viral vectors for gene transfer to the Central Nervous System Neurological Diseases Research
Sanofi-Aventis (Vitry sur Seine, França)
2006/12 Modelling and gene silencing in Machado-Joseph disease. IV Encontro Anual do CNC
CNC- Centro de Neurociências e Biologia Celular da Universidade de Coimbra - Biocant (Cantanhede, Portugal)
2006/12 Gene silencing in the CNS: Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo. XV National Congress of Biochemistry
(Aveiro, Portugal)
2006/11 Novas tecnologias aplicadas ao medicamento experimental: Terapia Génica do sistema nervoso. Clinical Trial Management: Global Strategies for a Global World
Simpósio Núcleo de Estudantes de Farmácia (Coimbra, Portugal)
2006/05 Lentiviral vectors for gene therapy of neurodegenerative disorders. 1º ciclo de Simpósios da Sociedade Portuguesa de Ciências Farmacêuticas (SPCF)
(Lisboa, Portugal)
2006/04 siRNA delivery by Tf-associated lipoplexes: a novel non-viral strategy to mediate gene silencing in neurons. Congress of the German Pharmacological Society
German Pharmacological Society (Mainz, Alemanha)
2005/12 Cationic Liposome-mediated In Vivo Gene Transfer to the CNS. XIV National Congress of Biochemistry
(Vilamoura, Algarve, Portugal)
2005/12 Vectores virais para terapia Génica do sistema nervoso; Dos genes à inovação terapêutica.
Simpósio Núcleo de Estudantes de Farmácia (Coimbra, Portugal)
2004/06 Applications of Lentiviral Vectors in Polyglutamine disorders. Advanced methods for industrial production, purification and characterization of gene vectors
(Evry, França)
2004/02 Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin 3 gene silencing by lentiviral mediated delivery of double-stranded RNAs. 2nd European Conference and Practical Course on Pre-clinical Gene Transfer to Train Researchers on Gene Therapy
Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB) (Barcelona, Espanha)
2002/09 A new lentiviral-based model of Huntington's disease in rats. (Invited Speaker) Novel Therapeutic Opportunities in Neurodegenerative Disease
Universidade de Aveiro (Aveiro, Portugal)
2002/06 Lentiviral-based gene delivery approaches for therapeutic and functional studies in Huntington’s disease. Ciclo de Seminários do Centro de Neurociências
(Coimbra, Portugal)
2002/03 Gene Therapy for Neurodegenerative diseases: Lentiviral vectors in Huntington's disease. (Invited Speaker) Jornadas Albert Netter, Biotecnologia e Genética em Ginecologia
Sociedade Europeia de Ginecologia (Coimbra, Portugal)
2001/08 Progressive neuropathology in the striatum of rats injected with lentiviral vectors encoding various mutant huntingtin fragments. 19th International Meeting of the World Federation of Neurology Research Group on Huntington’s Disease
World Federation of Neurology Research Group on Huntington's Disease (Copenhagen, Dinamarca)
2001/08 Neuroprotective effect of interleukin-6 and IL6R chimera in the quinolinic acid rat model of Huntington’s disease. 19th International Meeting of the World Federation of Neurology Research Group on Huntington’s Disease
World Federation of Neurology Research Group on Huntington’s Disease (Copenhagen, Dinamarca)
2001/06 Lentiviral-mediated delivery of mutant huntingtin (Htt) in the striatum of rats induces a neuropathology modulated by polyglutamine repeat size, Htt expression levels and protein length. Gordon Conference on CAG triplet repeat disorders
Gordon-Mount Holyoke College (Estados Unidos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022 - Atual Jisette Nuñez Título da tese: Drug repurposing, immunological surveillance, and vaccine development for COVID-19 - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2022.12572.BD Orientadores: Luís Pereira de Almeida e Dina Pereira
Orientador
2022 - Atual Beatriz Serra Título da tese: Validation of the brain-targeting AAV-PHP.eB encoding the cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type-3 - towards the understanding of the neuroprotective mechanism - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2022.11448.BD Orientadores: Luís Pereira de Almeida e Rita Perfeito
Orientador
2021 - Atual Miguel Lopes Título da tese: Enhanced AAV vector toolkit for the generation of novel animal models and therapeutic strategies for polyglutamine diseases - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2021.05776.BD Orientadores: Luís Pereira de Almeida e Rui Jorge Nobre
Orientador
2021 - Atual Frederico Pena - Título da tese: High-content screening of a novel therapy for Machado-Joseph disease in reporter gene-edited induced pluripotent stem cells - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2021.07163.BD Orientadores: Luís Pereira de Almeida e Pedro Perdigão
Orientador
2021 - Atual Carina Henriques Título da tese: Towards Clinical Translation of an AAV-based silencing strategy for therapy of Machado-Joseph disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2021.06939.BD Orientadores: Luís Pereira de Almeida; Rui Jorge Nobre & Romina Aron Badin
Orientador
2021 - Atual Ana Rita Fernandes Título da tese: Assessing the impact of ATXN3 silencing in the context of a human model of Machado-Joseph Disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2021.08215.BD Orientadores: Luís Pereira de Almeida e Pedro Perdigão
Orientador
2020 - Atual Diana Lobo - Título da tese: Overcoming the major roadblocks for successful AAV-based gene therapy for the CNS -Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.09668.BD Orientadores: Luis Pereira de Almeida; Rui Jorge Nobre & Cláudia Cavadas
Orientador
2020 - Atual Carolina Silva Título da tese: Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease -Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.07721.BD Orientadores: Rui Jorge Nobre e Luis Pereira de Almeida
Coorientador
2020 - Atual Daniel Henriques Título da tese: On the modulation of adult brain plasticity - a strategy to improve human neuroepithelial stem cells migration, differentiation, and functional integration upon cerebellar transplantation in Machado- Joseph disease - Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.07385.BD Orientadores: Liliana Mendonça; Luis Pereira de Almeida & Agnete Kirkeby
Coorientador
2020 - Atual Ricardo Moreira Título da tese: Brain-targeted lipid-based nanovesicles to deliver brain plasticity modulators - A strategy to enhance brain cell-replacement therapeutics in Machado-Joseph disease - Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.04751.BD Orientadores: Liliana Mendonça; Luis Pereira de Almeida & Clévio Nobrega
Coorientador
2020 - Atual Kevin Leandro - Título da tese: Extracellular vesicles as a platform to deliver CRISPR/Cas9 systems to treat Machado-Joseph Disease - Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.09513.BD Orientadores: Luís Pereira de Almeida e Francis Impens
Orientador
2020 - Atual Rodrigo Ribeiro - Título do projecto: Fine tuning circadian rhythm as an innovative approach against Machado-Joseph Disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: 2020.04850.BD Orientadores: Cláudia Cavadas e Maria Manuel; Luis Pereira de Almeida
Coorientador
2019 - Atual Patrick Silva - Título da tese: Finding a blood-based biomarker for Machado-Joseph Disease: an integrated approach Entidade Financiadora: Fundação para a Ciência e a Tecnologia, Referência da bolsa: SFRH/BD/148451/2019 Orientadores: Magda M. Santana e Luis Pereira de Almeida
Coorientador
2022 - 2023 Duo therapeutic strategy: silencing ataxin-3 while co-expressing a homologous sequence.
Coorientador
Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017 - 2022 David Ramos Título da tese: Exosome-based silencing of Machado-Joseph disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência: SFRH/BD/132618/2017 Orientador: Luís Pereira de Almeida Classificação: aprovado com distinção e louvor, Dezembro 2022 Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal Situação actual: Investigador de Pos-doutoramento.
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2022 Ana Cristina Vasconcelos-Ferreira - Título da tese: Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia Referência: SFRH/BD/87804/2012 Orientador: Luís Pereira de Almeida Classificação: aprovada com distinção e louvor, Abril 2022 Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal Situação actual: Medical Operations Specialist - AbbVie.
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2021/10/21 Sara Isabel Monteiro Lopes - Título da tese: Gene Editing Technologies to Machado-Joseph Disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia Referência: SFRH/BD/51673/2011 Orientador: Luís Pereira de Almeida Classificação: aprovada com distinção e louvor; Outubro 2021 Instituição que conferiu o grau: Instituto de Investigação Interdisciplinar da Universidade de Coimbra (IIIUC) Situação actual: Investigadora de Pos-doutoramento.
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - 2021 Maria Inês Martins - Título da tese: Assessing the role of nucleocytoplasmic transport mechanisms in Machado-Joseph disease pathogenesis - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência: PD/BD/114171/2016 Orientadores: Luís Pereira de Almeida e Thorsten Schmidt Classificação: aprovado com distinção e louvor; Outubro 2021 Instituição que conferiu o grau: Instituto de Investigação Interdisciplinar da Universidade de Coimbra (IIIUC).
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2012/10 - 2020/01 Dina Maria Pereira - Título da tese: The role of ageing in polyglutamine-induced neurodegeneration. A study in Machado-Joseph disease models - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência: SFRH / BD / 51965 / 2012; Orientadores: Luís Pereira de Almeida e Cláudia Cavadas; Classificação: aprovado com distinção e louvor; Situação actual: Investigadora de Pos-doutoramento.
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2017 Vítor Carmona Título da tese: MicroRNAs que têm como alvo o mRNA da Ataxina -3 na doença de Machado-Joseph: da patogénese à terapia Entidade financiadora: Fundação para a Ciência e a Tecnologia Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal; Classificação: aprovado com distinção e louvor; Orientadores: Luís Pereira de Almeida
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2017 Udaya Geetha Vijayakumar Título da tese: Papel da desregulação de microRNAs na patogénese da doença da Machado-Joseph - Entidade financiadora: União Europeia, Industrial Training Network TreatPolyQ Instituição que conferiu o grau: Universidade de Coimbra Classificação: aprovado com distinção e louvor; Orientadores: Luís Pereira de Almeida Situação actual: Investigadora de Pos-doutoramento na Irlanda do Norte.
Orientador
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2012 - 2017 Sara Matias Carmo Silva - Título da tese: Investigar o papel da ataxina-2 no hipotálamo: um novo mediador metabólico - Entidade financiadora: Fundação para a Ciência e a Tecnologia Referência: SFRH/BD/89035/2012 Orientadores: Cláudia Cavadas e Luís Pereira de Almeida Classificação: aprovado com distinção e louvor, Junho de 2017; Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal; Situação actual: Investigadora de Pos-doutoramento.
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012 - 2017 Janete Cunha-Santos - Título da tese: Retardamento da neurodegenerescência através de restrição calórica: dos mecanismos a terapia molecular - Entidade financiadora: Fundação para a Ciência e a Tecnologia Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal Classificação: aprovada com distinção e louvor; Orientadores: Cláudia Cavadas e Luís Pereira de Almeida Situação actual: Global Medical Director - Sanofi
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2015 Mariana Botelho da Rocha - Título da tese: Neuropeptide Y regulates autophagy in hypothalamus: a mechanism in life-span increase? - Entidade financiadora: Fundação para a Ciência e a Tecnologia, referência: SFRH/BD/73004/2010; Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal; Classificação: aprovada com distinção e louvor; Orientadores: Cláudia Cavadas e Luís Pereira de Almeida
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2015 Joana Duarte Neves - Título da tese: Neuropeptide Y gene transfer for neuroprotection in polyglutamine disorders - Entidade financiadora: Fundação para a Ciência e a Tecnologia, referência da bolsa: SFRH/BD/74993/2010); - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra - Orientadores: Luís Pereira de Almeida e Cláudia Cavadas - Classificação: aprovada com distinção e louvor; - Situação actual: Medical advisor na empresa Genzyme.
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2015 Carla Maria Nunes Lopes Título da tese: Characterization of human induced pluripotent stem cells derived from Huntington's disease patients - Entidade financiadora: Fundação para a Ciência e a Tecnologia Instituição que confere o grau: Faculdade de Medicina da Universidade de Coimbra, Portugal; Orientadores: Ana Cristina Rego, Sandrine Humbert e Luís Pereira de Almeida Situação actual: Investigadora de pós-doutoramento.
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2014 Isabel Onofre - Título da tese: “Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells” - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/61461/2009); - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra - Orientadores: Luís Pereira de Almeida e Henry Paulson - Classificação: aprovada com distinção e louvor; - Situação actual: Investigador de pós-doutoramento em SanDiego, EUA. -
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - 2013 Pedro Miguel Coutinho da Costa - Título da tese: MicroRNAs as molecular targets for non-viral gene therapy of glioblastoma multiforme - Entidade financiadora: Fundação para a Ciência e a Tecnologia, Referência: SFRH/BD/45902/2008; Instituição que confere o grau: Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Portugal; - Classificação: aprovado com distinção e louvor; - Orientadores: Conceição Pedroso Lima e Luís Pereira de Almeida
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2012 Mariana Oliveira da Conceição - Título da tese: Non-viral silencing of Machado-Joseph disease through the systemic route - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/38636/2007); - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra - Orientadores: Luís Pereira de Almeida e Conceição Pedroso de Lima - Classificação: aprovada com distinção e louvor; - Situação actual: Investigadora de pós-doutoramento em Oxford, Reino Unido.
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2011 Ana Teresa Antunes Simões - Título da tese: “Investigation of calpain-mediated cleavage of ataxin-3 in Machado-Joseph disease and its inhibition by gene therapy-mediated calpastatin overexpression” - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/38636/2007); - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra - Orientadores: Luís Pereira de Almeida e Carlos Bandeira Duarte
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2011 Nélio Mota Gonçalves Título da tese: Blocking A2A receptors as a new strategy to block Machado-joseph disease Entidade financiadora: Fundação para a Ciência e a Tecnologia Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra Orientadores: Luís Pereira de Almeida e Rodrigo Cunha
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2006 - 2011 Maria Isabel do Nascimento Ferreira - Título da tese: Gene Transfer approaches for Machado-Joseph disease - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/29479/2006; - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra; - Classificação: aprovada com distinção e louvor; - Situação actual: Medical advisor na empresa Takeda, Reino Unido.
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2006 - 2011 Lígia Maria de Sousa Ferreira - Título da tese: ¿Terapia génica para o NPY, a nível central e periférico, como estratégia para regulação do peso corporal e do apetite¿ - Entidade financiadora: Fundação para a Ciência e a Tecnologia - Referência da bolsa: SFRH/BD/30608/2006); - Instituição que confere o grau: Faculdade de Farmácia da Universidade de Coimbra, Portugal; - Orientadores: Luís Pereira de Almeida e Cláudia Cavadas - Classificação: aprovada com distinção e louvor; - Situação actual: Indústria na área regulamentar.
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2004 - 2009 Rui Jorge Gonçalves Pereira Nobre - Título da tese: “Correlation between adeno-associated virus and human papillomavirus infection: a novel correlation approach for the cervical cancer” - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/19165/2004; - Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra - Orientadores: Teresa Martins e Luís Pereira de Almeida - Classificação: aprovado com distinção e louvor; - Situação actual: Investigador no Centro de Neurociências e
Coorientador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2003 - 2007 Sandro José Paiva Fernandes Alves - Título da tese: Lentiviral vectors for gene silencing in polyglutamine disorders: ataxin-3 gene silencing by lentiviral-mediated delivery of double-stranded RNAs - Instituição que conferiu o grau: Faculdade de Farmácia da Universidade de Coimbra - Entidade financiadora: Fundação para a Ciência e a Tecnologia, - Referência da bolsa: SFRH/BD/12675/2003; - Classificação: aprovado com distinção e louvor; - Situção actual: Director de Estudos Pré-clinicos da empresa francesa BrainVectis
Orientador
Universidade de Coimbra Faculdade de Farmácia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018/12/13 - 2018/12/13 Terapia Génica: sucessos recentes e desafios futuros Mestrado integrado em Medicina Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/27 - 2018/11/27 Extracellular vesicles in brain disorders PhD Program in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/17 - 2018/11/17 Machado-Joseph disease: from mechanism to emerging therapies Mestrado Farmacologia Aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/10/31 - 2018/10/31 Genetic approaches to fight neurodegenerative diseases Master/PhD in Neurosciences Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2018/09/17 - 2018/09/21 Gene Therapy: Viral vectors for molecular surgery Programa Doutoral da Faculdade de Farmácia de Lisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/07/12 - 2018/07/12 Gene Therapy: dawn of a new era. European Drug Regulation and Advanced Therapies Course Universidade do Porto Faculdade de Farmácia, Portugal
2018/05/28 - 2018/05/28 Gene Therapy to Brain Disorders. Principles and Practice in Drug Development. Curso Avançado no âmbito do Programa Doutoral em Bioengenharia do MIT-Portugal Massachusetts Institute of Technology MIT Portugal Program, Portugal
2018/05/07 - 2018/05/11 Gene Therapy Approaches. Programa Doutoral em Biologia Experimental e Biomedicina Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/04/23 - 2018/04/27 Machado-Joseph disease: from models to reversibility. Programa Doutoral em Biologia Experimental e Biomedicina Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/04/26 - 2018/04/26 Gene Therapy Approaches. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/02/28 - 2018/02/28 Novel models and therapies in Machado-Joseph Programa Doutoral em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/28 - 2018/02/28 From microRNAs to gene silencing in Machado-Joseph disease. Programa Doutoral em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2017/12/11 - 2017/12/11 Extracellular vesicles in brain disorders. PhD Program in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2017/12/05 - 2017/12/05 On the mechanism of Machado-Joseph disease. PhD Program in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2017/11/08 - 2017/11/08 Gene Therapy to Brain Disorders Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2017/10/31 - 2017/10/31 Gene therapy approaches to fight neurodegenerative diseases. Master/PhD in Neurosciences Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2017/09/25 - 2017/09/25 Gene therapy and applications in neurologic diseases. FCT PhD PROGRAM IN MEDICINES AND PHARMACEUTICAL INNOVATION (I3DU) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/07/07 - 2017/07/07 Viral and non-viral gene therapy approaches for neurodegenerative disease treatment. FCT PhD PROGRAM IN MEDICINES AND PHARMACEUTICAL INNOVATION (I3DU) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/03/25 - 2017/03/25 Translational Research in Machado Joseph disease. From Genotype to Phenotype. PhD Programme in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2017/03/15 - 2017/03/15 Genetic approaches to fight neurodegenerative diseases. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/11/22 - 2016/11/22 Stem Cells: from biology to Brain Repair and Disease Modelling. “Mecanismos Moleculares de Doença” Programa de Doutoramento em Ciencias da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2016/11/12 - 2016/11/12 Da Investigação à terapia da doença de Machado-Joseph. Mestrado em Farmacologia Aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/11/12 - 2016/11/12 Da Investigação à terapia da doença de Machado-Joseph. Mestrado em Farmacologia Aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/10/12 - 2016/10/12 Advanced Brain Therapies: the case of Machado-Joseph disease Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2016/10/06 - 2016/10/06 Vetores virais para terapia génica. Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas; Programa de Doutoramento em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06/15 - 2016/06/15 Advanced Therapies for Brain Disorders. Programa Doutoral em Biologia Experimental e Biomedicina Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/05/23 - 2016/05/23 Silencing brain disease. Licenciaturas em Ciências Biomédicas, Bioquímica, Biologia, Biologia Marinha e Mestrado Integrado em Ciências Farmacêuticas Universidade do Algarve, Portugal
2016/04/14 - 2016/04/14 Advanced Therapies for Brain Disorders. MIT- Portugal Bioengineering Program
2016/04/04 - 2016/04/04 Viral vectors for gene therapy. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/03/15 - 2016/03/15 Viral and non-viral gene therapy approaches for neurodegenerative disease treatment FCT PhD PROGRAM IN MEDICINES AND PHARMACEUTICAL INNOVATION (I3DU) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/11/14 - 2015/11/14 Doença de  Machado-Joseph: mecanismos fisiopatológicos e novas abordagens terapêuticas. Mestrado em Farmacologia Aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/11/09 - 2015/11/09 Regulation of proteostasis in the brain. Programa de Doutoramento em Ciencias da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10/29 - 2015/10/29 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2015/10/14 - 2015/10/14 Viral vectors for gene delivery : from disease modeling to therapy. Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas; Programa de Doutoramento em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2015/05/16 - 2015/05/16 Doença de  Machado-Joseph: mecanismos fisiopatológicos e novas abordagens terapêuticas. Mestrado em Farmacologia Aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/04/29 - 2015/04/29 Machado-Joseph disease: from models to reversibility. Programa Doutoral em Biologia Experimental e Biomedicina Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/04/15 - 2015/04/15 Advanced Therapies for the Central Nervous System: Gene and Stem cell therapies. Programa Doutoral em Biologia Experimental e Biomedicina Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/03/23 - 2015/03/23 Viral vectors for gene therapy. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/03/23 - 2015/03/23 Viral vectors for gene therapy. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/12/04 - 2014/12/04 Genetic approaches to fight neurodegenerative diseases. PhD/Master in Neurosciences Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/10/27 - 2014/10/27 Translational Research in Machado-Joseph Disease. Programa de Doutoramento em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2014/10/13 - 2014/10/13 Viral vectors for gene delivery : from disease modeling to therapy. Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas; Programa de Doutoramento em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2014/04/09 - 2014/04/09 Gene Therapy as a strategy of drug delivery to the Central Nervous System. MIT-Portugal Bioengineering PhD Programme
2014/03/28 - 2014/03/28 Viral vectors for gene therapy. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/01/20 - 2014/01/20 Machado-Joseph disease: from mechanism to disease-modifying therapies. Lisbon Biomed PhD Programme Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/01/16 - 2014/01/16 Viral vectors for gene delivery : from disease modeling to therapy. Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas; Programa de Doutoramento em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2014 Challenging animal models of Machado-Joseph disease. PhD Programme in Health Sciences (PhDHS); Interuniversitary PhD Programme in Aging and Chronic Diseases (PhDOC) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/12/05 - 2013/12/05 Genetic approaches to fight neurodegenerative diseases. Mestrado/Doutoramento em Neurociências Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013/11/19 - 2013/11/19 From Genotype to Phenotype -Translational Research in Machado Joseph Disease. Programa Doutoral em Biomedicina Universidade de Coimbra Faculdade de Medicina, Portugal
2013/10/16 - 2013/10/16 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2013/05/03 - 2013/05/03 Doenças de Huntington e Machado-Joseph: Estratégias de terapia molecular. Mestrado em Farmacologia aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/04/05 - 2013/04/05 Gene therapy for CNS Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/03/06 - 2013/03/06 Gene transfer with viral vectors: from animal models to gene therapy. Universidade do Porto Faculdade de Farmácia, Portugal
2013/02/20 - 2013/02/20 Crossing the blood-brain barrier with nucleic acids. Curso Avançado: Brain and ocular diseases: How to overcome the barriers? From basic science to imaging approaches? Universidade de Coimbra, Portugal
2013/01/29 - 2013/01/29 Gene Therapy as a strategy of drug delivery to the Central Nervous System. MIT-Portugal program
2013/01/07 - 2013/01/11 Gene transfer with viral vectors: from animal models to gene therapy. Doctoral Program in Experimental Biology and Biomedicine; Advanced Course "Gene and Cell therapy of CNS: from microRNAs to IPS cells and gene repair" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/12/12 - 2012/12/12 Genetic approaches to fight neurodegenerative diseases. Mestrado/Doutoramento em Neurociências Universidade de Lisboa Faculdade de Medicina, Portugal
2012/12/03 - 2012/12/09 Gene transfer with viral vectors: from animal models to gene therapy Treat PolyQ training week: Generation and analysis of transgenic model organisms Universitatsklinikum Tübingen Institut für Medizinische Genetik und angewandte Genomik, Alemanha
2012/11/27 - 2012/11/27 From Genotype to Phenotype -Translational Research in Machado Joseph Disease. Programa Doutoral em Biomedicina Universidade de Coimbra Faculdade de Medicina, Portugal
2012/11/19 - 2012/11/23 Induced Pluripotent Stem Cells Doctoral Program in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2012/10/23 - 2012/10/23 Vectors for Gene Therapy. Programa de doutoramento em ciências da saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2012/10/18 - 2012/10/18 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2012/10/13 - 2012/10/13 Vectores virais para terapia génica do sistema nervoso. Curso Biotecnologia: Terapias Avançadas IEC – Instituto de Educação e Cidadania, Portugal
2012/05/19 - 2012/05/19 Doenças de Huntington e Machado-Joseph: Estratégias de terapia molecular. Mestrado em Farmacologia aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/04/12 - 2012/04/12 Viral vectors for gene therapy. Mestrado em Biologia Celular e Molecular
2012/04/12 - 2012/04/12 Gene therapy for CNS. Mestrado em Biologia Celular e Molecular Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/02/24 - 2012/02/24 Modifying Machado-Joseph disease. Doctoral Programme in Health Sciences Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/24 - 2012/01/24 Gene Therapy as a strategy of drug delivery to the Central Nervous System. MIT-Portugal program
2011/12/07 - 2011/12/07 Genetic approaches to fight neurodegenerative diseases. Mestrado/Doutoramento em Neurociências Universidade de Lisboa Faculdade de Medicina, Portugal
2011/11/17 - 2011/11/17 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles and Practice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2011/11/09 - 2011/11/09 Terapia génica. Programa Doutoral em Ciências da Saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2011/10/24 - 2011/10/28 Modeling and modifying Machado-Joseph progression. Programa Doutoral em Biologia Experimental e Biomedicina (PDBEB) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/09/26 - 2011/09/26 Vectors for Gene Therapy. Programa de doutoramento em ciências da saúde Universidade de Coimbra Faculdade de Medicina, Portugal
2011/06/01 - 2011/06/01 Terapia génica do sistema nervoso. (Invited Speaker) Mestrado em Regulação e Avaliação do Medicamento e Produtos de Saúde Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/05/20 - 2011/05/20 Doenças de Huntington e Machado-Joseph: Estratégias de terapia molecular. Mestrado em Farmacologia aplicada Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/04/15 - 2011/04/15 Terapia génica do sistema nervoso. Universidade do Algarve, Portugal
2011/03/30 - 2011/03/30 Terapia génica da doença de Machado-Joseph. Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/07/15 - 2010/07/21 Gene therapy in neurodegeneration Workshop “Molecular Mechanisms in Neurodegeneration: From Molecule to Cures" Harvard Medical School Portugal- Program in Translational Research and information
2010/05/29 - 2010/05/30 shRNAs for silencing Machado-Joseph's disease; Workshop: "Novel Experimental Therapies for Diseases of the Nervous System". Harvard Medical School Portugal- Program in Translational Research and information
2009/11/19 - 2009/11/19 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles and Pratice in Drug Development Massachusetts Institute of Technology, Estados Unidos
2008/06/08 - 2008/06/10 From the frying pan into the brain: lipoplexes for CNS gene delivery. Gene Therapy Workshop NeuroNE Workshop
2007/10/25 - 2007/10/25 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles of Drug Development Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/10/11 - 2007/10/11 Gene Therapy as a strategy of drug delivery to the Central Nervous System Principles of Drug Development Massachusetts Institute of Technology, Estados Unidos

Membro de associação

Nome da associação Tipo de participação
1991/06 - Atual Ordem dos Farmacêuticos
Atual Sociedade Portuguesa de Bioquímica
Atual Sociedade Portuguesa de Neurociências
Atual Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC)
Atual Society of Controlled Release
Atual Society for Neurosciences (SFN) - Sociedade Americana de Neurociências
Atual European Society for Gene and Cell Therapy

Tutoria

Tópico Nome do aluno
2022 - Atual Projeto em colaboração com a empresa farmacêutica F. Hoffmann - La Roche Ltd (Roche Group). Postdoctoral Researcher Sara Isabel Monteiro Lopes
2019 - Atual SpreadSilencing - Postdoctoral Researcher Pedro Perdigão
2014 - Atual Role and mechanisms of alpha-synuclein spreading in Parkinson’s disease. Postdoctoral Researcher Rita Perfeito
2014 - Atual Biomarkers for Machado Joseph-disease: from discovery to drug development no âmbito do projecto BrainHealth2020.. Postdoctoral Researcher Magda Santana
2013 - Atual Investigating the role of the Let-7 microRNA in Machado-Joseph disease - Postdoctoral Researcher Sónia Duarte
2012 - Atual Mesenchymal stem cells for Machado-Joseph disease therapy. Postdoctoral Researcher Catarina Miranda
2010 - Atual Combining transplantation of neural stem cells and mutante ataxin-3 gene silencing as a new therapeutic strategy for Machado-Joseph disease - Postdoctoral Researcher Liliana Simões Mendonça
2009 - Atual Silencing Machado-Joseph disease through the systemic route. Postdoctoral Researcher Rui Jorge Gonçalves Pereira Nobre
2020/02 - 2022/11 Calpain inhibition as a therapeutic strategy in Machado-Joseph Disease (Blade Therapeutics). Postdoctoral Researcher Dina Maria da Silva Rodrigues Pereira
2015 - 2019 CRISPR-based systems in the treatment of Machado-Joseph disease - Postdoctoral Researcher Carlos Matos
2007 - 2019 Calpain-mediated proteolysis in Machado-Joseph disease: biomarker and therapeutic target. Postdoctoral Researcher Ana Teresa Antunes Simões
2011 - 2016 Searching for the microRNA maestro in the central regulation of food intake and obesity. Postdoctoral Researcher Lígia Maria de Sousa Ferreira
2009 - 2016 Unraveling the molecular mechanisms of protein interactions in Machado-Joseph Disease: can Ataxin-2 modulate the Ataxin3 induced neurodegeneration? - Postdoctoral Researcher Clévio David Rodrigues Nobrega
2011 - 2013 Neuropeptide Y as a caloric restriction mimetic: a new target for aging? Postdoctoral Researcher Célia Alexandra Ferreira de Oliveira Aveleira
2009 - 2010 Projecto Model-PolyQ. - Postdoctoral Researcher Ana Rita Álvaro
Distinções

Prémio

2022 Travel Grant - Rufino-Ramos D., Leandro, K., Carmona V., Martins, I.M., Albuquerque P., Faro R., Perfeito, Nobre, R., Pereira de Almeida, L. Intranasal delivery of Extracellular Vesicles carrying silencing sequences alleviates Spinocerebellar Ataxia
2022 Travel Grant - Rufino-Ramos D, Leandro K, O'Brien K, Perdigão P, Pinto M, Santana M, Solinge T, Mahjoum S, Breakefield X, Breyne K, de Almeida LP. “Extracellular communication in the brain through functional transfer of CRE ExRNA” ,23-29 July, 2022, Ex
Gordon and Rose McAlpine Foundation for Neuroscience Research, Estados Unidos
2022 Travel Grant - Rufino-Ramos D., Leandro, K., Carmona V., Martins, I.M., Albuquerque P., Faro R., Perfeito, Nobre, R., Pereira de Almeida, L. “Extracellular Vesicles packaging and delivery of silencing sequences to alleviate a brain disorder” 26-29 June
2022 Travel Grant - Rufino-Ramos D., Leandro, K., Carmona V., Martins, I.M., Albuquerque P., Faro R., Perfeito, Nobre, R., Pereira de Almeida, L. Extracellular Vesicles carrying silencing sequences alleviate Machado-Joseph Disease (MJD)¿, 26-29 May, 2022
International Society for Extracellular Vesicles, Estados Unidos
2022 Conference Fellowship Award (Portuguese Society for Stem Cells and Cell Therapies). "Barros I, Gonzaga D, Lobo D, Martins I, Silva A, Duarte S, Nobre RJ, de Almeida LP* and Miranda CO* (2022).
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2022 Travel Grant – (National Ataxia Foundation). Martins, Inês Morgado; Sowa, Anna Sergeevna; Rufino-Ramos, David; Lobo, Diana Duarte; Leandro, Kevin; Vasconcelos-Ferreira, Ana; Pereira, Dina; Carmona, Vítor; Riess, Olaf; Thorsten, Schmidt; Pereira de Almeida
National Ataxia Foundation, Estados Unidos
2022 Best Oral Communication in Basic Research. Perdigão P, Matos C, Lopes S, Fernandes R, Lopes M, Conceição A, Faro R, Santana M, Adão D, Rufino-Ramos D, Leandro K, Nobre R, Pereira de Almeida L. Modelling Machado-Joseph Disease in patient-derived isogeni
Sociedade Portuguesa de Genética Humana, Portugal
2021 - Building Tomorrow Together – Roche Portugal Ideas Contest- 1st Prize
Roche Portugal, Portugal
2021 ESCI Young Investigator Award - 2nd place. Miranda CO, Lobo D, Nobre RJ, Gonzaga D, Barros MI, Martins MI, Castelhano J, Pereira D, Sereno J, Koeppen A, Castelo-Branco M, de Almeida LP. 55TH ANNUAL SCIENTIFIC MEETING OF the ESCI
2018 Prémio Janssen Innovação 2018- 2ª Edição do Prémio Janssen Inovação (2018) “Ataxin-2 in the hypothalamus: a new molecular target for metabolism and circadian rhythm regulation”; Autores: Sara Carmo-Silva, Clévio Nóbrega, Mariana Botelho, Marisa Marques
2018 Best work in basic science. Lopes, S.M., Nobre, R.J., Lopes, M.M., Nóbrega, C., Matos, C.A., Ferreira, A.V., Sanjana, N., Hsu, P., Ran, F.A., Cong, L., Zhang, F., Pereira de Almeida, L.; “Tailoring gene editing strategies for the treatment of Machado-J
Portuguese Society of Movement Disorders (SPDMov), Portugal
2016 Prémio Janssen Innovação 2016- 2º prémio. 1ª Edição do Prémio Janssen Inovação (2016) “Novel therapeutic approach to alleviate neuropathology and motor deficits in Machado–Joseph disease mouse models: molecular and pharmacological activation of SIRT1
Janssen-Cilag Farmacêutica Lda, Portugal

Outra distinção

2022 Publication selected as the Editor's Choice (Gene Therapy Journal; November 1st, 2022). The publication: Miguel M. Lopes, Jacques Paysan, José Rino, Sara M. Lopes, Luís Pereira de Almeida*, Luísa Cortes*, Rui Jorge Nobre*. (2022)
2022 Front cover of the Gene Therapy Journal (Volume 29, Issue 12, December 1st, 2022). Selection of an image of the publication: Miguel M. Lopes, Jacques Paysan, José Rino, Sara M. Lopes, Luís Pereira de Almeida*, Luísa Cortes*, Rui Jorge Nobre*. (2022)
2021 Best Speed Talk. Rufino-Ramos D., Carmona V., Martins, I.M., Leandro, K., Albuquerque P., Faro R., Perfeito, R., Girão, H., Nobre, R., Pereira de Almeida, L.
2011 Artigo Destaque_SPN2011 - atribuído ao primeiro autor e orientando Sandro Alves pelo artigo Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Human Molecular Genetics 2010 Apr 9
Sociedade Portuguesa de Neurociencias, Portugal
2010 Melhor trabalho português publicado em 2008 com impacto na área da genética humana e/ou médica atribuído ao orientando Sandro Alves, pelo artigo “Allele-specific RNA silencing of mutant ataxin-3..." Sociedade Portug
Sociedade Portuguesa de Genética Humana, Portugal
2009 Research Award -Project:"Modulation of autophagy as a novel therapeutic strategy for Machado-Joseph disease".
National Ataxia Foundation, USA/ Duration: 2010, Portugal
2009 Artigo Destaque_SPN2009 - atribuído ao primeiro autor e orientando Sandro Alves pelo artigo Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Hum Mol Genet. 2008; 17: 2071-2083
Sociedade Portuguesa de Neurociencias, Portugal
2004 Research award: -"Lentiviral vector-based silencing of endogenous rat ataxin-3", Reference #8 04/05
National Ataxia Foundation, USA, Portugal